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Aliases for CD300E Gene

Aliases for CD300E Gene

  • CD300e Molecule 2 3
  • CD300e Antigen 2 3 4
  • CD300LE 3 4 6
  • IREM2 3 4 6
  • CLM2 3 4 6
  • Immune Receptor Expressed On Myeloid Cells 2 3 4
  • Polymeric Immunoglobulin Receptor 2 3 4
  • CD300 Antigen Like Family Member E 2 3
  • CD300 Antigen-Like Family Member E 3 4
  • Poly-Ig Receptor 2 3 4
  • CMRF35-A5 3 4
  • IREM-2 3 4
  • PIgR-2 3 4
  • CLM-2 3 4
  • PIgR2 3 4
  • CMRF35-Like Molecule 2 3
  • CMRF35A5 4

External Ids for CD300E Gene

Previous HGNC Symbols for CD300E Gene

  • CD300LE

Previous GeneCards Identifiers for CD300E Gene

  • GC17M070119
  • GC17M072606
  • GC17M068017

Summaries for CD300E Gene

Entrez Gene Summary for CD300E Gene

  • This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

GeneCards Summary for CD300E Gene

CD300E (CD300e Molecule) is a Protein Coding gene. Diseases associated with CD300E include lice infestation and tungiasis. Among its related pathways are Signaling by FGFR. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot for CD300E Gene

  • Probably acts as an activating receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300E Gene

Genomics for CD300E Gene

Regulatory Elements for CD300E Gene

Genomic Location for CD300E Gene

Start:
74,609,883 bp from pter
End:
74,623,758 bp from pter
Size:
13,876 bases
Orientation:
Minus strand

Genomic View for CD300E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300E Gene

Proteins for CD300E Gene

  • Protein details for CD300E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496F6-CLM2_HUMAN
    Recommended name:
    CMRF35-like molecule 2
    Protein Accession:
    Q496F6
    Secondary Accessions:
    • B4DNS1
    • Q7Z7I3

    Protein attributes for CD300E Gene

    Size:
    205 amino acids
    Molecular mass:
    22918 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for CD300E Gene

Proteomics data for CD300E Gene at MOPED

Post-translational modifications for CD300E Gene

Other Protein References for CD300E Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD300E (CD300e/LMIR6)

No data available for DME Specific Peptides for CD300E Gene

Domains for CD300E Gene

Gene Families for CD300E Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300E Gene

Suggested Antigen Peptide Sequences for CD300E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q496F6

UniProtKB/Swiss-Prot:

CLM2_HUMAN :
  • Q496F6
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300E: view

Function for CD300E Gene

Molecular function for CD300E Gene

UniProtKB/Swiss-Prot Function: Probably acts as an activating receptor.

Gene Ontology (GO) - Molecular Function for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD300E: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD300E Gene

Localization for CD300E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300E Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300E Gene COMPARTMENTS Subcellular localization image for CD300E gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD300E: view

Pathways for CD300E Gene

SuperPathways for CD300E Gene

Superpath Contained pathways
1 Signaling by FGFR
genes like me logo Genes that share pathways with CD300E: view

Pathways by source for CD300E Gene

1 Reactome pathway for CD300E Gene

Interacting Proteins for CD300E Gene

Gene Ontology (GO) - Biological Process for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CD300E: view

Transcripts for CD300E Gene

mRNA/cDNA for CD300E Gene

(17) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300E Gene

CD300e molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300E

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300E Gene

No ASD Table

Relevant External Links for CD300E Gene

GeneLoc Exon Structure for
CD300E
ECgene alternative splicing isoforms for
CD300E

Expression for CD300E Gene

mRNA expression in normal human tissues for CD300E Gene

mRNA differential expression in normal tissues according to GTEx for CD300E Gene

This gene is overexpressed in Whole Blood (35.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300E Gene

SOURCE GeneReport for Unigene cluster for CD300E Gene Hs.158954

mRNA Expression by UniProt/SwissProt for CD300E Gene

Q496F6-CLM2_HUMAN
Tissue specificity: Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).
genes like me logo Genes that share expressions with CD300E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CD300E Gene

Orthologs for CD300E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300E 35
  • 99.16 (n)
  • 98.48 (a)
CD300E 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD300E 35
  • 74.63 (n)
  • 63.9 (a)
CD300E 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD300E 35
  • 75.61 (n)
  • 65.36 (a)
CD300E 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd300e 35
  • 71.65 (n)
  • 60.92 (a)
Cd300e 16
Cd300e 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300e 35
  • 70.81 (n)
  • 59.89 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for CD300E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300E Gene

ENSEMBL:
Gene Tree for CD300E (if available)
TreeFam:
Gene Tree for CD300E (if available)

Paralogs for CD300E Gene

Paralogs for CD300E Gene

Selected SIMAP similar genes for CD300E Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD300E: view

Variants for CD300E Gene

Sequence variations from dbSNP and Humsavar for CD300E Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs479782 -- 74,611,829(-) GGGCC(A/G)TGGAT utr-variant-3-prime
rs480399 -- 74,625,115(-) ACTGT(C/T)AGCTC upstream-variant-2KB
rs493852 -- 74,613,106(+) ACTCT(C/T)GCTTT intron-variant
rs504497 -- 74,624,819(-) aggca(C/T)gtgcc upstream-variant-2KB
rs507018 -- 74,625,209(-) actgc(A/G)cctgc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD300E Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
esv2604772 CNV Insertion 19546169

Relevant External Links for CD300E Gene

HapMap Linkage Disequilibrium report
CD300E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300E Gene

Disorders for CD300E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CD300E Gene including...

Search for CD300E Gene in MalaCards »

(3) University of Copenhagen DISEASES for CD300E Gene

Relevant External Links for CD300E

Human Genome Epidemiology (HuGE) Navigator
CD300E
genes like me logo Genes that share disorders with CD300E: view

No data available for UniProtKB/Swiss-Prot for CD300E Gene

Publications for CD300E Gene

  1. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. (PMID: 15557162) Aguilar H. … Lopez-Botet M. (J. Immunol. 2004) 2 3 4
  2. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. (PMID: 15549731) Alvarez-Errico D. … Lopez-Botet M. (Eur. J. Immunol. 2004) 2 3
  3. Monocytes immunoselected via the novel monocyte specific molecule, CD300e, differentiate into active migratory dendritic cells. (PMID: 17414321) Clark G.J. … Hart D.N. (J. Immunother. 2007) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. (PMID: 16920917) Martinez-Barriocanal A. … Sayos J. (J. Immunol. 2006) 3

Products for CD300E Gene

Sources for CD300E Gene

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