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Aliases for CD300E Gene

Aliases for CD300E Gene

  • CD300e Molecule 2 3 5
  • CD300e Antigen 2 3 4
  • Immune Receptor Expressed On Myeloid Cells 2 3 4
  • Polymeric Immunoglobulin Receptor 2 3 4
  • CD300 Antigen Like Family Member E 2 3
  • CD300 Antigen-Like Family Member E 3 4
  • Poly-Ig Receptor 2 3 4
  • CMRF35-A5 3 4
  • CD300LE 3 4
  • IREM-2 3 4
  • PIgR-2 3 4
  • CLM-2 3 4
  • IREM2 3 4
  • PIgR2 3 4
  • CLM2 3 4
  • CMRF35A5 4

External Ids for CD300E Gene

Previous HGNC Symbols for CD300E Gene

  • CD300LE

Previous GeneCards Identifiers for CD300E Gene

  • GC17M070119
  • GC17M072606
  • GC17M068017

Summaries for CD300E Gene

Entrez Gene Summary for CD300E Gene

  • This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

GeneCards Summary for CD300E Gene

CD300E (CD300e Molecule) is a Protein Coding gene. Diseases associated with CD300E include Tungiasis and Lice Infestation. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. An important paralog of this gene is CD300LD.

UniProtKB/Swiss-Prot for CD300E Gene

  • Probably acts as an activating receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300E Gene

Genomics for CD300E Gene

Regulatory Elements for CD300E Gene

Enhancers for CD300E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD300E on UCSC Golden Path with GeneCards custom track

Promoters for CD300E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD300E on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300E Gene

Chromosome:
17
Start:
74,609,883 bp from pter
End:
74,623,758 bp from pter
Size:
13,876 bases
Orientation:
Minus strand

Genomic View for CD300E Gene

Genes around CD300E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300E Gene

Proteins for CD300E Gene

  • Protein details for CD300E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496F6-CLM2_HUMAN
    Recommended name:
    CMRF35-like molecule 2
    Protein Accession:
    Q496F6
    Secondary Accessions:
    • B4DNS1
    • Q7Z7I3

    Protein attributes for CD300E Gene

    Size:
    205 amino acids
    Molecular mass:
    22918 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for CD300E Gene

Proteomics data for CD300E Gene at MOPED

Post-translational modifications for CD300E Gene

Other Protein References for CD300E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD300E (CD300e/LMIR6)

No data available for DME Specific Peptides for CD300E Gene

Domains & Families for CD300E Gene

Gene Families for CD300E Gene

Protein Domains for CD300E Gene

Suggested Antigen Peptide Sequences for CD300E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q496F6

UniProtKB/Swiss-Prot:

CLM2_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300E: view

Function for CD300E Gene

Molecular function for CD300E Gene

UniProtKB/Swiss-Prot Function:
Probably acts as an activating receptor.

Phenotypes for CD300E Gene

genes like me logo Genes that share phenotypes with CD300E: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD300E Gene

Localization for CD300E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300E Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300E Gene COMPARTMENTS Subcellular localization image for CD300E gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD300E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD300E: view

Pathways & Interactions for CD300E Gene

genes like me logo Genes that share pathways with CD300E: view

Interacting Proteins for CD300E Gene

Gene Ontology (GO) - Biological Process for CD300E Gene

None

No data available for SIGNOR curated interactions for CD300E Gene

Drugs & Compounds for CD300E Gene

No Compound Related Data Available

Transcripts for CD300E Gene

mRNA/cDNA for CD300E Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300E Gene

CD300e molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300E Gene

No ASD Table

Relevant External Links for CD300E Gene

GeneLoc Exon Structure for
CD300E
ECgene alternative splicing isoforms for
CD300E

Expression for CD300E Gene

mRNA expression in normal human tissues for CD300E Gene

mRNA differential expression in normal tissues according to GTEx for CD300E Gene

This gene is overexpressed in Whole Blood (x35.8).

Protein differential expression in normal tissues from HIPED for CD300E Gene

This gene is overexpressed in Monocytes (46.9) and Urine (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300E Gene



SOURCE GeneReport for Unigene cluster for CD300E Gene Hs.158954

mRNA Expression by UniProt/SwissProt for CD300E Gene

Q496F6-CLM2_HUMAN
Tissue specificity: Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).
genes like me logo Genes that share expression patterns with CD300E: view

Protein tissue co-expression partners for CD300E Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CD300E Gene

Orthologs for CD300E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD300E 35
  • 74.63 (n)
  • 63.9 (a)
CD300E 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD300E 35
  • 75.61 (n)
  • 65.36 (a)
CD300E 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd300e 35
  • 71.65 (n)
  • 60.92 (a)
Cd300e 16
Cd300e 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD300E 35
  • 99.16 (n)
  • 98.48 (a)
CD300E 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd300e 35
  • 70.81 (n)
  • 59.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for CD300E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300E Gene

ENSEMBL:
Gene Tree for CD300E (if available)
TreeFam:
Gene Tree for CD300E (if available)

Paralogs for CD300E Gene

Paralogs for CD300E Gene

(7) SIMAP similar genes for CD300E Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD300E: view

Variants for CD300E Gene

Sequence variations from dbSNP and Humsavar for CD300E Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_039129 -
VAR_039130 A colorectal cancer sample
VAR_039131 -

Structural Variations from Database of Genomic Variants (DGV) for CD300E Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
esv2604772 CNV Insertion 19546169

Variation tolerance for CD300E Gene

Gene Damage Index Score: 0.89; 18.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD300E Gene

Disorders for CD300E Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD300E Gene - From: DISEASES

Disorder Aliases PubMed IDs
tungiasis
  • chigger flea
lice infestation
  • infestation by pediculus
parasitic ectoparasitic infectious disease
  • ectoparasitism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CD300E

Human Genome Epidemiology (HuGE) Navigator
CD300E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300E
genes like me logo Genes that share disorders with CD300E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD300E Gene

Publications for CD300E Gene

  1. Molecular characterization of a novel immune receptor restricted to the monocytic lineage. (PMID: 15557162) Aguilar H. … Lopez-Botet M. (J. Immunol. 2004) 2 3 4 67
  2. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. (PMID: 15549731) Alvarez-Errico D. … Lopez-Botet M. (Eur. J. Immunol. 2004) 2 3
  3. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski R.E. … Clark G.J. (Immunol. Lett. 2013) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. (PMID: 20039296) Brckalo T. … LA^pez-Botet M. (Eur. J. Immunol. 2010) 3

Products for CD300E Gene

Sources for CD300E Gene

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