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Aliases for CD300C Gene

Aliases for CD300C Gene

  • CD300c Molecule 2 3 5
  • CD300c Antigen 2 3 4
  • Immunoglobulin Superfamily Member 16 3 4
  • CD300 Antigen-Like Family Member C 3 4
  • CMRF35-A1 3 4
  • CMRF35A1 3 4
  • CMRF-35 3 4
  • CMRF35A 3 4
  • CMRF35 3 4
  • IGSF16 3 4
  • CLM-6 3 4
  • CMRF35A Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Antigen 3
  • CMRF-35A 3
  • LIR 3

External Ids for CD300C Gene

Previous GeneCards Identifiers for CD300C Gene

  • GC17M070049
  • GC17M072537
  • GC17M067946

Summaries for CD300C Gene

Entrez Gene Summary for CD300C Gene

  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300C Gene

CD300C (CD300c Molecule) is a Protein Coding gene. Diseases associated with CD300C include Middle Cerebral Artery Infarction. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD300LD.

Gene Wiki entry for CD300C Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300C Gene

Genomics for CD300C Gene

Regulatory Elements for CD300C Gene

Enhancers for CD300C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD300C on UCSC Golden Path with GeneCards custom track

Promoters for CD300C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD300C on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300C Gene

Chromosome:
17
Start:
74,541,065 bp from pter
End:
74,546,171 bp from pter
Size:
5,107 bases
Orientation:
Minus strand

Genomic View for CD300C Gene

Genes around CD300C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300C Gene

Proteins for CD300C Gene

  • Protein details for CD300C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08708-CLM6_HUMAN
    Recommended name:
    CMRF35-like molecule 6
    Protein Accession:
    Q08708

    Protein attributes for CD300C Gene

    Size:
    224 amino acids
    Molecular mass:
    24830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD300C Gene

Proteomics data for CD300C Gene at MOPED

Post-translational modifications for CD300C Gene

  • Glycosylation at Asn 90 and Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for CD300C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300C Gene

Domains & Families for CD300C Gene

Gene Families for CD300C Gene

Protein Domains for CD300C Gene

Suggested Antigen Peptide Sequences for CD300C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08708

UniProtKB/Swiss-Prot:

CLM6_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300C: view

Function for CD300C Gene

genes like me logo Genes that share phenotypes with CD300C: view

Animal Model Products

miRNA for CD300C Gene

miRTarBase miRNAs that target CD300C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD300C Gene

Localization for CD300C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300C Gene COMPARTMENTS Subcellular localization image for CD300C gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
lysosome 2
vacuole 2
cytoskeleton 1
endosome 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CD300C Gene

Pathways & Interactions for CD300C Gene

genes like me logo Genes that share pathways with CD300C: view

Pathways by source for CD300C Gene

Interacting Proteins for CD300C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329507%0d%0a9606.ENSP00000357484%0d%0a9606.ENSP00000265350%0d%0a
Selected Interacting proteins: ENSP00000329507 for CD300C Gene via STRING

Gene Ontology (GO) - Biological Process for CD300C Gene

None

No data available for SIGNOR curated interactions for CD300C Gene

Drugs & Compounds for CD300C Gene

No Compound Related Data Available

Transcripts for CD300C Gene

mRNA/cDNA for CD300C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300C Gene

CD300c molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300C Gene

No ASD Table

Relevant External Links for CD300C Gene

GeneLoc Exon Structure for
CD300C
ECgene alternative splicing isoforms for
CD300C

Expression for CD300C Gene

mRNA expression in normal human tissues for CD300C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300C Gene

This gene is overexpressed in Whole Blood (x25.0) and Spleen (x5.0).

SOURCE GeneReport for Unigene cluster for CD300C Gene Hs.2605

mRNA Expression by UniProt/SwissProt for CD300C Gene

Q08708-CLM6_HUMAN
Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.
genes like me logo Genes that share expression patterns with CD300C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CD300C Gene

Orthologs for CD300C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC526163 35
  • 69.89 (n)
  • 53.62 (a)
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD300C 35
  • 69 (n)
  • 52.8 (a)
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd300c 35
  • 65.48 (n)
  • 52.68 (a)
Cd300c 16
AF251705 36
  • 46 (a)
ManyToMany
Cd300a 36
  • 26 (a)
ManyToMany
Cd300c 36
  • 48 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CD300C 35
  • 97.77 (n)
  • 95.98 (a)
CD300C 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1561778 35
  • 67.33 (n)
  • 55.94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for CD300C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300C Gene

ENSEMBL:
Gene Tree for CD300C (if available)
TreeFam:
Gene Tree for CD300C (if available)

Paralogs for CD300C Gene

Paralogs for CD300C Gene

(5) SIMAP similar genes for CD300C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD300C Gene

genes like me logo Genes that share paralogs with CD300C: view

Variants for CD300C Gene

Sequence variations from dbSNP and Humsavar for CD300C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11870245 - 74,544,797(+) CTTTG(A/G)TCTCC reference, missense
rs1042773 -- 74,541,440(-) GATCC(A/T)CATGT utr-variant-3-prime
rs1042774 -- 74,541,433(-) ATGTG(A/T)CACAT utr-variant-3-prime
rs1699562 -- 74,542,640(+) TCCAC(C/G)CAGTA intron-variant
rs1699565 -- 74,547,277(-) CATGA(A/C)AGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD300C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv470600 CNV Loss 18288195

Variation tolerance for CD300C Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD300C Gene

Disorders for CD300C Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD300C Gene - From: DISEASES

Disorder Aliases PubMed IDs
middle cerebral artery infarction
  • infarction middle cerebral artery
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CD300C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300C
genes like me logo Genes that share disorders with CD300C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD300C Gene

Publications for CD300C Gene

  1. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PMID: 1349532) Jackson D.G. … Bell J.I. (Eur. J. Immunol. 1992) 2 3 4 23 67
  2. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark G.J. … Hart D.N.J. (Tissue Antigens 2000) 2 3 23
  3. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PMID: 11556966) Clark G.J. … Hart D.N. (Tissue Antigens 2001) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Human CD300C delivers an Fc receptor-I^-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. (PMID: 23372157) Takahashi M. … Kitaura J. (J. Biol. Chem. 2013) 3

Products for CD300C Gene

Sources for CD300C Gene

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