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Aliases for CD300C Gene

Aliases for CD300C Gene

  • CD300c Molecule 2 3
  • CD300c Antigen 2 3 4
  • CMRF35A 3 4 6
  • CMRF35 3 4 6
  • Immunoglobulin Superfamily Member 16 3 4
  • CD300 Antigen-Like Family Member C 3 4
  • CMRF35-A1 3 4
  • CMRF35A1 3 4
  • CMRF-35 3 4
  • IGSF16 3 4
  • CLM-6 3 4
  • CMRF35A Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35-Like Molecule 6 3
  • CMRF35 Antigen 3
  • CMRF-35A 3
  • LIR 3

External Ids for CD300C Gene

Previous GeneCards Identifiers for CD300C Gene

  • GC17M070049
  • GC17M072537
  • GC17M067946

Summaries for CD300C Gene

Entrez Gene Summary for CD300C Gene

  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300C Gene

CD300C (CD300c Molecule) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD300LG.

Gene Wiki entry for CD300C Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300C Gene

Genomics for CD300C Gene

Regulatory Elements for CD300C Gene

Genomic Location for CD300C Gene

74,541,065 bp from pter
74,546,171 bp from pter
5,107 bases
Minus strand

Genomic View for CD300C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300C Gene

Proteins for CD300C Gene

  • Protein details for CD300C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 6
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CD300C Gene

    224 amino acids
    Molecular mass:
    24830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD300C Gene

Proteomics data for CD300C Gene at MOPED

Post-translational modifications for CD300C Gene

  • Glycosylation at Asn90 and Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for CD300C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD300C (CD300c/LMIR2)

No data available for DME Specific Peptides for CD300C Gene

Domains for CD300C Gene

Gene Families for CD300C Gene

Protein Domains for CD300C Gene

Suggested Antigen Peptide Sequences for CD300C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300C: view

Function for CD300C Gene

Gene Ontology (GO) - Molecular Function for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 1349532
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD300C: view

Animal Model Products

miRNA for CD300C Gene

miRTarBase miRNAs that target CD300C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CD300C Gene

Localization for CD300C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD300C Gene COMPARTMENTS Subcellular localization image for CD300C gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 1349532
genes like me logo Genes that share ontologies with CD300C: view

Pathways for CD300C Gene

SuperPathways for CD300C Gene

No Data Available

Interacting Proteins for CD300C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329507 for CD300C Gene via STRING

Gene Ontology (GO) - Biological Process for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 1349532
GO:0007165 signal transduction TAS 1349532
genes like me logo Genes that share ontologies with CD300C: view

No data available for Pathways by source for CD300C Gene

Transcripts for CD300C Gene

mRNA/cDNA for CD300C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300C Gene

CD300c molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300C Gene

No ASD Table

Relevant External Links for CD300C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300C Gene

mRNA expression in normal human tissues for CD300C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300C Gene

This gene is overexpressed in Whole Blood (25.0) and Spleen (5.0).

SOURCE GeneReport for Unigene cluster for CD300C Gene Hs.2605

mRNA Expression by UniProt/SwissProt for CD300C Gene

Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines
genes like me logo Genes that share expressions with CD300C: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CD300C Gene

Orthologs for CD300C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC526163 35
  • 69.89 (n)
  • 53.62 (a)
-- 36
  • 42 (a)
-- 36
  • 30 (a)
(Canis familiaris)
Mammalia CD300C 35
  • 69 (n)
  • 52.8 (a)
-- 36
  • 43 (a)
-- 36
  • 27 (a)
(Mus musculus)
Mammalia Cd300c 35
  • 65.48 (n)
  • 52.68 (a)
Cd300c 16
AF251705 36
  • 46 (a)
Cd300a 36
  • 26 (a)
Cd300c 36
  • 48 (a)
(Pan troglodytes)
Mammalia CD300C 35
  • 97.77 (n)
  • 95.98 (a)
CD300C 36
  • 96 (a)
(Rattus norvegicus)
Mammalia RGD1561778 35
  • 67.33 (n)
  • 55.94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 39 (a)
-- 36
  • 36 (a)
-- 36
  • 38 (a)
-- 36
  • 35 (a)
(Gallus gallus)
Aves -- 36
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
-- 36
  • 34 (a)
Species with no ortholog for CD300C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300C Gene

Gene Tree for CD300C (if available)
Gene Tree for CD300C (if available)

Paralogs for CD300C Gene

Paralogs for CD300C Gene

(5) SIMAP similar genes for CD300C Gene using alignment to 1 proteins: Pseudogenes for CD300C Gene

genes like me logo Genes that share paralogs with CD300C: view

Variants for CD300C Gene

Sequence variations from dbSNP and Humsavar for CD300C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs186970425 -- 74,542,289(+) GCTGC(A/G)AGAGA intron-variant
rs186902898 -- 74,546,178(+) ACATG(C/T)CACTT upstream-variant-2KB
rs186866459 -- 74,543,588(+) CCTTT(C/T)CTCCT intron-variant
rs186810813 -- 74,547,613(+) CTTCC(C/T)GGGTT upstream-variant-2KB
rs186085321 -- 74,547,118(+) CCTCC(A/T)TTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD300C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv470600 CNV Loss 18288195

Relevant External Links for CD300C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300C Gene

Disorders for CD300C Gene

No disorders were found for CD300C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CD300C Gene

Publications for CD300C Gene

  1. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PMID: 1349532) Jackson D.G. … Bell J.I. (Eur. J. Immunol. 1992) 2 3 4 23
  2. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark G.J. … Hart D.N.J. (Tissue Antigens 2000) 2 3 23
  3. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PMID: 11556966) Clark G.J. … Hart D.N. (Tissue Antigens 2001) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. (PMID: 18535206) Ju X. … Clark G.J. (Blood 2008) 3

Products for CD300C Gene

Sources for CD300C Gene

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