Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD300C Gene

Aliases for CD300C Gene

  • CD300c Molecule 2 3 5
  • CD300c Antigen 2 3 4
  • Immunoglobulin Superfamily Member 16 3 4
  • CD300 Antigen-Like Family Member C 3 4
  • CMRF35-A1 3 4
  • CMRF35A1 3 4
  • CMRF-35 3 4
  • CMRF35A 3 4
  • CMRF35 3 4
  • IGSF16 3 4
  • CLM-6 3 4
  • CMRF35A Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35 Leukocyte Immunoglobulin-Like Receptor 3
  • CMRF35-Like Molecule 6 3
  • CMRF35 Antigen 3
  • CMRF-35A 3
  • LIR 3

External Ids for CD300C Gene

Previous GeneCards Identifiers for CD300C Gene

  • GC17M070049
  • GC17M072537
  • GC17M067946

Summaries for CD300C Gene

Entrez Gene Summary for CD300C Gene

  • The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300C Gene

CD300C (CD300c Molecule) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CD300A.

Gene Wiki entry for CD300C Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300C Gene

Genomics for CD300C Gene

Regulatory Elements for CD300C Gene

Enhancers for CD300C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074568 1.2 FANTOM5 Ensembl ENCODE 34.8 -23.0 -23030 2.4 TBP ARNT YBX1 GLI4 FOS EGR2 YY2 CEBPB ZNF645 SP1 LOC100130520 CD300E CD300C NAT9 NUP85 CD300LB NT5C ENSG00000266765 LINC02092 ENSG00000265927
GH17F074635 1.6 FANTOM5 Ensembl ENCODE 23 -93.1 -93055 8.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD ENSG00000236770 MIR3615 SLC9A3R1
GH17F074631 1.3 FANTOM5 Ensembl ENCODE 22.6 -86.5 -86505 2.6 IKZF1 MLLT1 CEBPG MYC SPI1 CD300E CD300C CD300LB CD300LF CD300LD RAB37 ENSG00000236770 TMEM104 CD300A SLC16A5
GH17F074567 0.6 Ensembl 22.4 -21.3 -21309 0.6 LOC100130520 CD300C LOC101928343 CD300LB CD300LD CD300E RAB37 ENSG00000236770
GH17F074547 1 FANTOM5 Ensembl 19.7 -1.6 -1631 0.4 MAX MYC CD300C CD300E CD300LB TMEM104 CD300LF CD300LD CD300A TTYH2 ENSG00000236770
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD300C on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300C Gene

74,541,065 bp from pter
74,546,171 bp from pter
5,107 bases
Minus strand

Genomic View for CD300C Gene

Genes around CD300C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300C Gene

Proteins for CD300C Gene

  • Protein details for CD300C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 6
    Protein Accession:

    Protein attributes for CD300C Gene

    224 amino acids
    Molecular mass:
    24830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD300C Gene

Post-translational modifications for CD300C Gene

  • Glycosylation at Asn 90 and Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for CD300C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300C Gene

Domains & Families for CD300C Gene

Gene Families for CD300C Gene

Protein Domains for CD300C Gene

Suggested Antigen Peptide Sequences for CD300C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300C: view

Function for CD300C Gene

Gene Ontology (GO) - Molecular Function for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 1349532
genes like me logo Genes that share ontologies with CD300C: view
genes like me logo Genes that share phenotypes with CD300C: view

Animal Models for CD300C Gene

MGI Knock Outs for CD300C:

Animal Model Products

miRNA for CD300C Gene

miRTarBase miRNAs that target CD300C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300C Gene

Localization for CD300C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD300C Gene COMPARTMENTS Subcellular localization image for CD300C gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
lysosome 2
vacuole 2
cytoskeleton 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1349532
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300C: view

Pathways & Interactions for CD300C Gene

genes like me logo Genes that share pathways with CD300C: view

Pathways by source for CD300C Gene

Interacting Proteins for CD300C Gene

Gene Ontology (GO) - Biological Process for CD300C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 1349532
GO:0007165 signal transduction IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300C: view

No data available for SIGNOR curated interactions for CD300C Gene

Transcripts for CD300C Gene

mRNA/cDNA for CD300C Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300C Gene

CD300c molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300C Gene

No ASD Table

Relevant External Links for CD300C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300C Gene

mRNA expression in normal human tissues for CD300C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300C Gene

This gene is overexpressed in Whole Blood (x25.0) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CD300C Gene:


SOURCE GeneReport for Unigene cluster for CD300C Gene:


mRNA Expression by UniProt/SwissProt for CD300C Gene:

Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.
genes like me logo Genes that share expression patterns with CD300C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CD300C Gene

Orthologs for CD300C Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300C 34 35
  • 97.77 (n)
(Bos Taurus)
Mammalia LOC526163 34
  • 69.89 (n)
-- 35
  • 42 (a)
-- 35
  • 30 (a)
(Canis familiaris)
Mammalia CD300C 34
  • 69 (n)
-- 35
  • 43 (a)
-- 35
  • 27 (a)
(Rattus norvegicus)
Mammalia RGD1561778 34
  • 67.33 (n)
(Mus musculus)
Mammalia Cd300c 34 35
  • 65.48 (n)
AF251705 35
  • 46 (a)
Cd300a 35
  • 26 (a)
Cd300c2 16
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 39 (a)
-- 35
  • 38 (a)
-- 35
  • 38 (a)
-- 35
  • 36 (a)
-- 35
  • 35 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 30 (a)
(Gallus gallus)
Aves -- 35
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
-- 35
  • 30 (a)
Species where no ortholog for CD300C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300C Gene

Gene Tree for CD300C (if available)
Gene Tree for CD300C (if available)

Paralogs for CD300C Gene

Paralogs for CD300C Gene

(5) SIMAP similar genes for CD300C Gene using alignment to 1 proteins: Pseudogenes for CD300C Gene

genes like me logo Genes that share paralogs with CD300C: view

Variants for CD300C Gene

Sequence variations from dbSNP and Humsavar for CD300C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1042773 -- 74,541,440(-) GATCC(A/T)CATGT intron-variant, utr-variant-3-prime
rs1042774 -- 74,541,433(-) ATGTG(A/T)CACAT intron-variant, utr-variant-3-prime
rs10852753 -- 74,539,870(+) GGTAG(C/T)TCATG intron-variant
rs111360466 -- 74,538,428(+) CCTCC(C/T)CAGGG intron-variant
rs111380989 -- 74,544,656(+) AGTCT(C/T)GGAGC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD300C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv470600 CNV loss 18288195
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300C Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300C Gene

Disorders for CD300C Gene

Relevant External Links for CD300C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CD300C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300C Gene

Publications for CD300C Gene

  1. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PMID: 1349532) Jackson D.G. … Bell J.I. (Eur. J. Immunol. 1992) 2 3 4 22 64
  2. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PMID: 11556966) Clark G.J. … Hart D.N. (Tissue Antigens 2001) 3 4 22 64
  3. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark G.J. … Hart D.N.J. (Tissue Antigens 2000) 2 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CD300C Gene

Sources for CD300C Gene

Loading form....