CD300C Gene
protein-coding GIFtS: 47
GCID: GC17M072537
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CD300c molecule(Previous name: CD300c antigen )
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Aliases
for CD300C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD300c Molecule1 2 | | CMRF-352 3 | | CMRF351 2 3 5 | | CMRF35-A12 3 | | CMRF35A1 2 3 5 | | CMRF35A12 3 | | IGSF161 2 3 | | CD300 Antigen-Like Family Member C2 3 | | CD300c Antigen1 2 3 | | CMRF35 Antigen2 | | CMRF-35A1 2 | | CMRF35 Leukocyte Immunoglobulin-Like Receptor2 | | LIR1 2 | | CMRF35-Like Molecule 62 | | Immunoglobulin Superfamily Member 162 3 | | CMRF35A Leukocyte Immunoglobulin-Like Receptor2 | | CLM-62 3 | | IgSF163 |
Export aliases for CD300C gene to outside databasesPrevious GC identifers: GC17M070049 GC17M067946 |
Summaries
for CD300C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD300C:
The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes,neutrophils, and some T and B lymphocytes (Jackson et al., 1992 (PubMed 1349532)).(supplied by OMIM, Mar 2008)
Gene Wiki entry for CD300C
|
Genomic Views
for CD300C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD300C gene promoter:
NF-1/L NF-1 XBP-1 NF-kappaB AREB6 PPAR-gamma1 NF-kappaB2 PPAR-gamma2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD300C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2CD300C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M072537: view genomic region
(about GC identifiers)
Start:
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72,537,247 bp from pter |
End:
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72,542,282 bp from pter |
Size:
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5,036 bases |
Orientation:
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minus strand |
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Proteins
for CD300C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLM6_HUMAN, Q08708 (See
protein sequence)Recommended Name: CMRF35-like molecule 6 precursor Size: 224 amino acids; 24830 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)Explore the universe of human proteins at neXtProt for CD300C: NX_Q08708
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08708
CD300C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006669.1
ENSEMBL proteins: ENSP00000329507
Human Recombinant Protein Products for CD300C:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
TAS | 1349532 |
CD300C for ontologies About GeneDecksing
CD300C Antibody Products:
Assay Products for CD300C: |
Protein
Domains /
Families
for CD300C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD300C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08708ProtoNet protein and cluster: Q08708 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: CLM6_HUMAN, Q08708Similarity: Belongs to the CD300 familySimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for CD300C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane signaling receptor activity |
TAS | 1349532 |
CD300C for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CD300C (NM_006678) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD300C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300C |
|
Pathways & Interactions
for CD300C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD300C
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CD300C (ENSP000003295074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006968 | cellular defense response |
TAS | 1349532 |
CD300C for ontologies About GeneDecksing
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Drugs & Compounds
for CD300C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CD300C
Search CenterWatch for drugs/clinical trials and news about CD300C / CLM6
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Transcripts
for CD300C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CD300C gene: NM_006678.4 Unigene Cluster for CD300C: CD300c molecule Hs.2605 [show with all ESTs]Unigene Representative Sequence: BM9219861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330793(uc002jky.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CD300C (NM_006678) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD300C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300C |
Additional cDNA sequence: BC022279.1 X66171.1 1 DOTS entry: DT.97837924 24/35 AceView cDNA sequences (see all 35): CD742752 BU726296 CD365749 CD365737 AI820764 AA587107 BM922826 AA774118 BX115024 BF509957 AI791961 NM_006678 CD366620 BF820876 CB529088 CD369386 BM690966 BG539563 BI818235 BM721280 BI823863 CD364805 AI732664 CD370422
GeneLoc Exon Structure
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Expression
for CD300C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD300C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACGCCCC
About this image
See CD300C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD300C
SOURCE GeneReport for Unigene cluster: Hs.2605
UniProtKB/Swiss-Prot: CLM6_HUMAN, Q08708Tissue specificity: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- andB-lymphocytes and lymphocytic cell lines
SABiosciences Custom PCR Arrays for CD300C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD300C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300C |
Orthologs
for CD300C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for CD300C gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CD300C (if available)
TreeFam Gene Tree for CD300C (if available) |
Paralogs
for CD300C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CD300C gene
- CD300LG2 CD300A2 CD300LB2 CD300LF2 CD300LD2 CD300E2
5 SIMAP similar genes for CD300C using alignment to 1 protein entry: CLM6_HUMAN:CD300A CD300E CD300LD CD300LB CD300LF
CD300C for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CD300C
PGOHUM00000237177
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Genomic Variants
for CD300C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CD300C (72537247 - 72542282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CD300C
5 CNVs: 34522 8852 53066 5336 7171 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300C |
|
Disorders
/ Diseases
for CD300C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD300C for disorders About GeneDecksing
OMIM gene information: 606786
OMIM disorders: --
5  diseases for CD300C: About MalaCardsmiddle cerebral artery infarction chronic fatigue syndrome leprosy cerebritis
psoriasis
Export disorders for CD300C gene to outside databases
|
Publications
for CD300C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD300C gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with CD300C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. (PubMed id 1349532)1, 2, 3, 9 Jackson D.G.... Bell J.I. (1992)
- The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. (PubMed id 11556966)1, 2, 9 Clark G.J.... Hart D.N. (2001)
- The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PubMed id 10746781)1, 3, 9 Clark G.J.... Hart D.N.J. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential expression of CD300a/c on human TH1 and TH17 cells. (PubMed id 22046970)1 Simhadri V.R....Borrego F. (2011)
- Expression and function of CD300 in NK cells. (PubMed id 20656921)1 Lankry D....Mandelboim O. (2010)
- The CD300 family of molecules are evolutionarily sign ificant regulators of leukocyte functions. (PubMed id 19359216)1 Clark G.J....Hart D.N. (2009)
- The CD300 molecules regulate monocyte and dendritic c ell functions. (PubMed id 19592130)1 Clark G.J....Hart D.N. (2009)
- CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. (PubMed id 18535206)1 Ju X....Clark G.J. (2008)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
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External Searches for CD300C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CD300C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD300C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD300C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD300C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CD300C gene:
Search GeneIP for patents involving CD300C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD300C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CD300C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD300C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300C | | | OriGene Protein Over-expression Lysate for CD300C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CD300C | | OriGene 3'-UTR Clone for CD300C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CD300C | | OriGene Custom Protein Services for CD300C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD300C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300C |
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| | | | Search Tocris compounds for CD300C |
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 | | | CD300C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CD300C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300C |
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