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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD300A Gene

protein-coding   GIFtS: 52
GCID: GC17P072462

CD300a Molecule

(Previous name: CD300a antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD300a Molecule1 2     IRp602 3
CD300a Antigen1 2 3     CD300 Antigen-Like Family Member A2 3
CMRF35H2 3 5     NK Inhibitory Receptor2 3
Immunoglobulin Superfamily Member 122 3     CMRF35H92 5
Inhibitory Receptor Protein 602 3     CMRF-35H2
CLM-82 3     IRC12
CMRF-35-H92 3     IRC22
CMRF35-H2 3     CMRF35-Like Molecule 82
CMRF35-H92 3     CMRF35H Leukocyte Immunoglobulin-Like Receptor2
IGSF122 3     Leukocyte Membrane Antigen2
IRC1/IRC22 3     IgSF123

External Ids:    HGNC: 193191   Entrez Gene: 113142   Ensembl: ENSG000001678517   OMIM: 6067905   UniProtKB: Q9UGN43   

Export aliases for CD300A gene to outside databases

Previous GC identifers: GC17P069975 GC17P067871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD300A Gene:
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved
in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the
other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Feb 2012)

GeneCards Summary for CD300A Gene: 
CD300A (CD300a molecule) is a protein-coding gene. Diseases associated with CD300A include psoriasis, and hepatitis b. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer
(NK) cells, and to the down-regulation of mast cell degranulation

Gene Wiki entry for CD300A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD300A gene promoter:
         Bach1   Tal-1   AML1a   MyoD   LUN-1   Nkx5-1   E47   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD300A promoter sequence
   Search SABiosciences Chromatin IP Primers for CD300A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

CD300A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD300A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072462:  view genomic region     (about GC identifiers)

Start:
72,462,522 bp from pter      End:
72,480,933 bp from pter
Size:
18,412 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4 (See protein sequence)
Recommended Name: CMRF35-like molecule 8 precursor  
Size: 299 amino acids; 33201 Da
Subunit: Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAF28906.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF28906.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for CD300A:
2Q87 (3D)    
Secondary accessions: A8MW96 O95100 Q9HD97 Q9P0F3 Q9UBK4 Q9UMS9 Q9UMT0
Alternative splicing: 4 isoforms:  Q9UGN4-1   Q9UGN4-2   Q9UGN4-3   Q9UGN4-4   

Explore the universe of human proteins at neXtProt for CD300A: NX_Q9UGN4

Explore proteomics data for CD300A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UGN4

  • CD300A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD300A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243770.1  NP_009192.2  

    ENSEMBL proteins: 
     ENSP00000353259   ENSP00000376401   ENSP00000354564   ENSP00000308188   ENSP00000463189  

    Human Recombinant Protein Products for CD300A: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CD300A
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for CD300A
    Novus Biologicals CD300A Proteins
    Novus Biologicals CD300A Lysates
    Sino Biological Recombinant Protein for CD300A
    Sino Biological Cell Lysate for CD300A 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CD300A for ontologies           About GeneDecksing



    CD300A Antibody Products: 
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    Novus Biologicals CD300A Antibodies
    Abcam antibodies for CD300A
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD300A
    LSBio Antibodies in human, mouse, rat for CD300A 

    Assay Products for CD300A: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UGN4

    ProtoNet protein and cluster: Q9UGN4

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Similarity: Belongs to the CD300 family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD300A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLM8_HUMAN, Q9UGN4
    Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer
    (NK) cells, and to the down-regulation of mast cell degranulation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CD300A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd300a):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CD300A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd300atm1Shib for CD300A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD300A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD300A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD300A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD300A 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD300A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD300A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD300A
    Sirion Biotech Customized adenovirus for overexpression of CD300A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD300A (see all 7)
    OriGene ORF clones in mouse, rat for CD300A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD300A (NM_007261)
    Sino Biological Human cDNA Clone for CD300A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD300A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A
    Sirion Biotech Customized lentivirus for stable overexpression of CD300A 
                         Customized lentivirus expression plasmids for stable overexpression of CD300A 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD300A
    Search LifeMap BioReagents cell lines for CD300A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD300A

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    CD300A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD300A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD300A (CLM8)

    1 Novoseek inferred chemical compound relationship for CD300A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 29.1 2 17588661 (1), 10540326 (1)

    Search CenterWatch for drugs/clinical trials and news about CD300A / CLM8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD300A gene (2 alternative transcripts): 
    NM_001256841.1  NM_007261.3  

    Unigene Cluster for CD300A:

    CD300a molecule
    Hs.9688  [show with all ESTs]
    Unigene Representative Sequence: NM_007261
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360141(uc002jkv.3 uc002jkw.3 uc010dfr.3 uc010dfs.3)
    ENST00000392625 ENST00000361933 ENST00000310828 ENST00000582319 ENST00000577511

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD300A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD300A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300A
    Clone
    Products:
         
    OriGene clones in human, mouse for CD300A (see all 7)
    OriGene ORF clones in mouse, rat for CD300A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD300A (NM_007261)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD300A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A
    Sirion Biotech Customized lentivirus for stable overexpression of CD300A 
                         Customized lentivirus expression plasmids for stable overexpression of CD300A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD300A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD300A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300A

    Additional mRNA sequence: 

    AF020314.1 AF161346.1 AJ010101.1 AJ010102.1 AJ010103.1 AJ224864.1 AJ238323.1 AK309631.1 
    AK309636.1 BC020681.1 BC032352.1 

    2 DOTS entries:

    DT.211864  DT.95168172 

    24/80 AceView cDNA sequences (see all 80):

    CR616430 F08389 AJ010102 CB053994 CA428265 BC032352 BQ072720 AJ010101 
    BE858395 BM919189 AW475063 AJ010103 CR617958 AW103533 BQ072616 BI818272 
    BI820565 AI146394 BM923053 AJ238323 BQ072600 BX107737 BI910172 BF061956 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD300A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:        -     -                     


    ECgene alternative splicing isoforms for CD300A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD300A expression in normal human tissues (normalized intensities)      CD300A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCAGAAC
    CD300A Expression
    About this image


    CD300A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See CD300A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD300A

    SOURCE GeneReport for Unigene cluster: Hs.9688

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Tissue specificity: Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic
    cells, mast cells, granulocytes and monocytes

        SABiosciences Custom PCR Arrays for CD300A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD300A gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd300a1 , 5 CD300A antigen1, 5 64.58(n)1
    50.87(a)1
      11 (80.54 cM)5
    2173031  NM_170758.31  NP_739564.11 
     1148900415 
    chicken
    (Gallus gallus)
    Aves CD300A1 CD300a molecule 42.95(n)
    32.02(a)
      422107  NM_001039295.1  NP_001034384.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    35(a)
    25(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(116020650-116030691)
    2(115986797-115996463)
    zebrafish
    (Danio rerio)
    Actinopterygii BX927114.16
    si:dkey-1c7.26
    (see all 5)
    si:dkey-1c7.2
    (see all 5)
    28(a)
    17(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(58482375-58483019)
    1(58460908-58465872)


    ENSEMBL Gene Tree for CD300A (if available)
    TreeFam Gene Tree for CD300A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD300A gene
    CD300LG2  CD300LB2  CD300C2  CD300LF2  CD300LD2  CD300E2  
    2 SIMAP similar genes for CD300A using alignment to 2 protein entries:     CLM8_HUMAN (see all proteins):
    CD300C    CD300E

    CD300A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD300A
    PGOHUM00000237176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/620 SNPs in CD300A are shown (see all 620)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379877511,2
    C--72460525(+) CTCACC/TGCAAC 2 -- us2k10--------
    rs1494718291,2
    --72460541(+) CCTCTC/TGAGTT 2 -- us2k10--------
    rs110777501,2
    C,F,A,H--72460549(+) GTTCAC/AGCGAT 2 -- us2k19Minor allele frequency- A:0.25NA WA CSA 20
    rs1867895281,2
    --72460734(+) CCCGGC/TCCGAA 2 -- us2k10--------
    rs80819991,2
    C,F--72460774(+) ATCTAT/GGACTG 2 -- us2k1 tfbs33Minor allele frequency- G:0.12NA WA 122
    rs1482448601,2
    --72460811(+) CCACCA/GGGCTT 2 -- us2k10--------
    rs126003511,2
    C,F,A,H--72460849(+) CCATAC/GGTCTC 2 -- us2k111Minor allele frequency- G:0.39NA WA CSA EA 372
    rs1429315201,2
    --72460871(+) GACACC/GTTCGT 2 -- us2k10--------
    rs1916590781,2
    --72460886(+) AAGGCA/GCCCCT 2 -- us2k10--------
    rs80783431,2
    C,F--72460904(+) GAAGGA/CAGAGG 2 -- us2k1 trp31Minor allele frequency- C:0.07WA 118

    HapMap Linkage Disequilibrium report for CD300A (72462522 - 72480933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CD300A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv12e196CNV Duplication17116639
    nsv470600CNV Loss18288195
    esv33995CNV Loss17666407
    nsv908741CNV Loss21882294
    esv2751770CNV Gain17911159
    dgv372n27CNV Gain19166990
    nsv517569CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD300A
    DNA2.0 Custom Variant and Variant Library Synthesis for CD300A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606790    OMIM disorders: --

    4 diseases for CD300A:    About MalaCards
    psoriasis    hepatitis b    ovarian cancer    hepatitis


    CD300A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD300A
    Human Genome Epidemiology (HuGE) Navigator: CD300A (2 documents)

    Export disorders for CD300A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD300A gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CD300A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PubMed id 10746781)1, 2, 3 Clark G.J.... Hart D.N.J. (2000)
    2. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. (PubMed id 9701027)1, 2, 3 Green B.J.... Hart D.N.J. (1998)
    3. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PubMed id 10540326)1, 2, 9 Cantoni C.... Moretta A. (1999)
    4. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. (PubMed id 16339535)1, 2, 9 Bachelet I.... Levi-Schaffer F. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. (PubMed id 17588661)1, 9 Alvarez Y....Borrego F. (2008)
    7. CD300a is expressed on human basophils and seems to in hibit IgE/FceRI-dependent anaphylactic degranulation. (PubMed id 22173928)1 Sabato V....Ebo D.G. (2012)
    8. Functional requirements for inhibitory signal transmis sion by the immunomodulatory receptor CD300a. (PubMed id 22537350)1 DeBell K.E....Borrego F. (2012)
    9. Identification of phosphatidylserine as a ligand for t he CD300a immunoreceptor. (PubMed id 22185693)1 Nakahashi-Oda C....Shibuya A. (2012)
    10. Human CD300a binds to phosphatidylethanolamine and pho sphatidylserine, and modulates the phagocytosis of dead cells. (PubMed id 22302738)1 Simhadri V.R....Borrego F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11314 HGNC: 19319 AceView: CMRF-35H Ensembl:ENSG00000167851 euGenes: HUgn11314
    ECgene: CD300A H-InvDB: CD300A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD300A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD300A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD300A gene:
    Search GeneIP for patents involving CD300A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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