Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD300A Gene

protein-coding   GIFtS: 51
GCID: GC17P072462

CD300a molecule

(Previous name: CD300a antigen )
 Explore 4 diseases affiliated with
CD300A via our new
 Human Malady Compendium 
Biological research products
for CD300A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CD300a Molecule1 2     IRC1/IRC22 3
CMRF35H1 2 3 5     IRp602 3
CMRF-35-H91 2 3     CD300 Antigen-Like Family Member A2 3
IGSF121 2 3     NK Inhibitory Receptor2 3
CD300a Antigen1 2 3     CMRF35H92 5
IRC11 2     Irp601
IRC21 2     CMRF-35H2
Immunoglobulin Superfamily Member 122 3     CMRF35-Like Molecule 82
Inhibitory Receptor Protein 602 3     CMRF35H Leukocyte Immunoglobulin-Like Receptor2
CLM-82 3     Leukocyte Membrane Antigen2
CMRF35-H2 3     IgSF123
CMRF35-H92 3     

External Ids:    HGNC: 193191   Entrez Gene: 113142   Ensembl: ENSG000001678517   OMIM: 6067905   UniProtKB: Q9UGN43   

Export aliases for CD300A gene to outside databases

Previous GC identifers: GC17P069975 GC17P067871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD300A:
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in
immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other
family members. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK)
cells, and to the down-regulation of mast cell degranulation

Gene Wiki entry for CD300A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD300A gene promoter:
         Bach1   Tal-1   AML1a   MyoD   LUN-1   Nkx5-1   E47   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD300A promoter sequence
   Search SABiosciences Chromatin IP Primers for CD300A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

CD300A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD300A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072462:  view genomic region     (about GC identifiers)

Start:
72,462,522 bp from pter      End:
72,480,933 bp from pter
Size:
18,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4 (See protein sequence)
Recommended Name: CMRF35-like molecule 8 precursor  
Size: 299 amino acids; 33201 Da
Subunit: Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAF28906.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF28906.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for CD300A:
2Q87 (3D)    
Secondary accessions: A8MW96 O95100 Q9HD97 Q9P0F3 Q9UBK4 Q9UMS9 Q9UMT0
Alternative splicing: 4 isoforms:  Q9UGN4-1   Q9UGN4-2   Q9UGN4-3   Q9UGN4-4   

Explore the universe of human proteins at neXtProt for CD300A: NX_Q9UGN4

Post-translational modifications:

  • Phosphorylated on tyrosine1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UGN4

  • CD300A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243770.1  NP_009192.2  

    ENSEMBL proteins: 
     ENSP00000353259   ENSP00000376401   ENSP00000354564   ENSP00000308188   ENSP00000463189  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD300A (CD300a/LMIR1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CD300A
    OriGene Custom Protein Services for CD300A 
    GenScript Custom Purified and Recombinant Proteins Services for CD300A
    Novus Biologicals CD300A Proteins
    Novus Biologicals CD300A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD300A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    CD300A for ontologies           About GeneDecksing



    CD300A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD300A (CD300a/LMIR1)
    OriGene Antibodies: CD300A
    OriGene Custom Antibody Services for CD300A 
    GenScript Custom Superior Antibodies Services for CD300A
    Novus Biologicals CD300A Antibodies
    Abcam antibodies for CD300A 
    Uscn Antibodies for CD300A
    ThermoFisher Antibodies for CD300A

    Assay Products for CD300A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for CD300A (CD300a/LMIR1)
    GenScript Custom Assay Services for CD300A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CD300A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CD300A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UGN4

    ProtoNet protein and cluster: Q9UGN4

    1 Blocks protein family: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Similarity: Belongs to the CD300 family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK)
    cells, and to the down-regulation of mast cell degranulation

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CD300A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD300A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD300A (see all 4)
    OriGene shRNA RFP: CD300A
    OriGene siRNA: CD300A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD300A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CD300A (NM_007261)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD300A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD300A
    Search LifeMap BioReagents cell lines for CD300A

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    CD300A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cd300atm1Shib for CD300A
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd300a):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CD300A for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD300A

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    CD300A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD300A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD300A
    1 Novoseek chemical compound relationship for CD300A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 29.1 2 17588661 (1), 10540326 (1)

    Search CenterWatch for drugs/clinical trials and news about CD300A / CLM8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD300A gene (2 alternative transcripts): 
    NM_001256841.1  NM_007261.3  

    Unigene Cluster for CD300A:

    CD300a molecule
    Hs.9688  [show with all ESTs]
    Unigene Representative Sequence: NM_007261
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360141(uc002jkv.3 uc002jkw.3 uc010dfr.3 uc010dfs.3)
    ENST00000392625 ENST00000361933 ENST00000310828 ENST00000582319 ENST00000577511


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CD300A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD300A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD300A (see all 4)
    OriGene shRNA RFP: CD300A
    OriGene siRNA: CD300A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300A
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CD300A (NM_007261)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD300A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD300A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300A

    Additional cDNA sequence: 

    AF020314.1 AF161346.1 AJ010101.1 AJ010102.1 AJ010103.1 AJ224864.1 AJ238323.1 AK309631.1 
    AK309636.1 BC020681.1 BC032352.1 

    2 DOTS entries:

    DT.211864  DT.95168172 

    24/80 AceView cDNA sequences (see all 80):

    AJ010101 AW475063 CR617958 CB053994 AW103533 BQ072616 AJ010102 BC032352 
    CA428265 BE858395 CR616430 BQ072720 AJ010103 BM919189 F08389 CD370295 
    AL554086 BI910172 AL576904 BI772449 AJ238323 AI863749 AA047284 BI820565 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD300A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:        -     -                     


    ECgene alternative splicing isoforms for CD300A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD300A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTCCAGAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CD300A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD300A

    SOURCE GeneReport for Unigene cluster: Hs.9688

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Tissue specificity: Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic
    cells, mast cells, granulocytes and monocytes

        SABiosciences Custom PCR Arrays for CD300A
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD300A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD300A gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CD300A1 CD300a molecule 42.95(n)
    32.02(a)
      422107  NM_001039295.1  NP_001034384.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD300LG6
    FAIM36
    --
    35(a)
    23(a)
    1 ↔ many
    possible ortholog
    2(116020650-116021999)
    2(115999765-116005747)
    zebrafish
    (Danio rerio)
    Actinopterygii CU896655.76
    BX927114.26
    (see all 11)
    --
    9(a)
    9(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    1(59304615-59307631)
    1(58441849-58448289)


    ENSEMBL Gene Tree for CD300A (if available)
    TreeFam Gene Tree for CD300A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD300A gene
    CD300LG2  CD300LB2  CD300C2  CD300LF2  CD300LD2  CD300E2  
    2 SIMAP similar genes for CD300A using alignment to 2 protein entries:     CLM8_HUMAN (see all proteins):
    CD300C    CD300E

    CD300A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD300A
    PGOHUM00000237176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 NCBI SNPs in CD300A are shown (see all 495    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379877511,2
    --72460525(+) CTCACC/TGCAAC 2 -- us2k10--------
    rs1494718291,2
    --72460541(+) CCTCTC/TGAGTT 2 -- us2k10--------
    rs110777501,2
    C,F,A,H,--72460549(+) GTTCAC/AGCGAT 2 -- us2k19Minor allele frequency- A:0.25NA WA CSA 20
    rs1867895281,2
    --72460734(+) CCCGGC/TCCGAA 2 -- us2k10--------
    rs80819991,2
    C,--72460774(+) ATCTAT/GGACTG 2 -- us2k1 tfbs33Minor allele frequency- G:0.12NA WA 122
    rs1482448601,2
    --72460811(+) CCACCA/GGGCTT 2 -- us2k10--------
    rs126003511,2
    C,F,A,H,--72460849(+) CCATAC/GGTCTC 2 -- us2k111Minor allele frequency- G:0.39NA WA CSA EA 372
    rs1429315201,2
    --72460871(+) GACACC/GTTCGT 2 -- us2k10--------
    rs1916590781,2
    --72460886(+) AAGGCA/GCCCCT 2 -- us2k10--------
    rs80783431,2
    C,F,--72460904(+) GAAGGA/CAGAGG 2 -- us2k1 trp31Minor allele frequency- C:0.07WA 118

    HapMap Linkage Disequilibrium report for CD300A (72462522 - 72480933 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CD300A
         5 CNVs: 34522 8852 53066 5336 7171

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300A
    DNA2.0 Custom Variant and Variant Library Synthesis for CD300A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CD300A for disorders           About GeneDecksing

    OMIM gene information: 606790    OMIM disorders: --

    4 diseases for CD300A:    About MalaCards
    hepatitis b    ovarian cancer    psoriasis    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: CD300A (2 documents)

    Export disorders for CD300A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD300A gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CD300A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PubMed id 10746781)1, 2, 3 Clark G.J.... Hart D.N.J. (2000)
    2. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. (PubMed id 9701027)1, 2, 3 Green B.J.... Hart D.N.J. (1998)
    3. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PubMed id 10540326)1, 2, 9 Cantoni C.... Moretta A. (1999)
    4. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. (PubMed id 16339535)1, 2, 9 Bachelet I.... Levi-Schaffer F. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. (PubMed id 17588661)1, 9 Alvarez Y....Borrego F. (2008)
    7. CD300a is expressed on human basophils and seems to in hibit IgE/FceRI-dependent anaphylactic degranulation. (PubMed id 22173928)1 Sabato V....Ebo D.G. (2012)
    8. Functional requirements for inhibitory signal transmis sion by the immunomodulatory receptor CD300a. (PubMed id 22537350)1 DeBell K.E....Borrego F. (2012)
    9. Identification of phosphatidylserine as a ligand for t he CD300a immunoreceptor. (PubMed id 22185693)1 Nakahashi-Oda C....Shibuya A. (2012)
    10. Human CD300a binds to phosphatidylethanolamine and pho sphatidylserine, and modulates the phagocytosis of dead cells. (PubMed id 22302738)1 Simhadri V.R....Borrego F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11314 HGNC: 19319 AceView: CMRF-35H Ensembl:ENSG00000167851 euGenes: HUgn11314
    ECgene: CD300A H-InvDB: CD300A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD300A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD300A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD300A gene:
    Search GeneIP for patents involving CD300A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD300A (CD300a/LMIR1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for CD300A (CD300a/LMIR1)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CD300A (CD300a/LMIR1)  
     OriGene Antibodies for CD300A   OriGene shRNA RFP for CD300A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD300A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300A  
     OriGene Protein Over-expression Lysate for CD300A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CD300A   OriGene 3'-UTR Clone for CD300A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD300A   OriGene Custom Protein Services for CD300A  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD300A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300A
     GenScript Custom Purified and Recombinant Proteins Services for CD300A GenScript cDNA clones with any tag delivered in your preferred vector for CD300A
     GenScript Custom Assay Services for CD300A GenScript Custom Superior Antibodies Services for CD300A
     GenScript Custom overexpressing Cell Line Services for CD300A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD300A promoter
     Search Chromatin IP Primers for CD300A
     RT2 qPCR Primer Assay in human, mouse, rat CD300A
     Search GNC Networks for CD300A
     SABiosciences Custom PCR Arrays for CD300A
     Search Tocris compounds for CD300A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD300A antibodies
     CD300A proteins
     CD300A lysates
     Antibodies for CD300A
     See all of Abcam's Antibodies, Kits and Proteins for CD300A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CD300A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CD300A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A
     SwitchGear 3'UTR luciferase reporter plasmids for CD300A
     SwitchGear Promoter luciferase reporter plasmids for CD300A
     ThermoFisher Antibodies for CD300A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD300A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4