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CD300A Gene

protein-coding   GIFtS: 54
GCID: GC17P072462

CD300a Molecule

(Previous name: CD300a antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD300a Molecule1 2     IRp602 3
CD300a Antigen1 2 3     CD300 Antigen-Like Family Member A2 3
CMRF35H2 3 5     NK Inhibitory Receptor2 3
Immunoglobulin Superfamily Member 122 3     CMRF35H92 5
Inhibitory Receptor Protein 602 3     CMRF-35H2
CLM-82 3     IRC12
CMRF-35-H92 3     IRC22
CMRF35-H2 3     CMRF35-Like Molecule 82
CMRF35-H92 3     CMRF35H Leukocyte Immunoglobulin-Like Receptor2
IGSF122 3     Leukocyte Membrane Antigen2
IRC1/IRC22 3     IgSF123

External Ids:    HGNC: 193191   Entrez Gene: 113142   Ensembl: ENSG000001678517   OMIM: 6067905   UniProtKB: Q9UGN43   

Export aliases for CD300A gene to outside databases

Previous GC identifers: GC17P069975 GC17P067871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD300A Gene:
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved
in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the
other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Feb 2012)

GeneCards Summary for CD300A Gene:
CD300A (CD300a molecule) is a protein-coding gene. Diseases associated with CD300A include psoriasis, and tonsillitis. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer
(NK) cells, and to the down-regulation of mast cell degranulation

Gene Wiki entry for CD300A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD300A gene promoter:
         Bach1   Tal-1   AML1a   MyoD   LUN-1   Nkx5-1   E47   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD300A promoter sequence
   Search Chromatin IP Primers for CD300A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD300A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

CD300A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD300A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072462:  view genomic region     (about GC identifiers)

Start:
72,462,522 bp from pter      End:
72,480,933 bp from pter
Size:
18,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4 (See protein sequence)
Recommended Name: CMRF35-like molecule 8 precursor  
Size: 299 amino acids; 33201 Da
Subunit: Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D
Sequence caution: Sequence=AAF28906.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF28906.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for CD300A:
2Q87 (3D)    
Secondary accessions: A8MW96 O95100 Q9HD97 Q9P0F3 Q9UBK4 Q9UMS9 Q9UMT0
Alternative splicing: 4 isoforms:  Q9UGN4-1   Q9UGN4-2   Q9UGN4-3   Q9UGN4-4   

Explore the universe of human proteins at neXtProt for CD300A: NX_Q9UGN4

Explore proteomics data for CD300A at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine1
  • Glycosylation2 at Asn83, Asn92
  • Modification sites at PhosphoSitePlus

  • See CD300A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243770.1  NP_009192.2  

    ENSEMBL proteins: 
     ENSP00000353259   ENSP00000376401   ENSP00000354564   ENSP00000308188   ENSP00000463189  

    CD300A Human Recombinant Protein Products:

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    Novus Biologicals CD300A Lysates
    Sino Biological Recombinant Protein for CD300A
    Sino Biological Cell Lysate for CD300A
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    Browse Proteins at Cloud-Clone Corp.

    CD300A Antibody Products:

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    CD300A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UGN4

    ProtoNet protein and cluster: Q9UGN4

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Similarity: Belongs to the CD300 family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD300A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLM8_HUMAN, Q9UGN4
    Function: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer
    (NK) cells, and to the down-regulation of mast cell degranulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA--
    GO:0005515protein binding IPI10540326
    GO:0008429phosphatidylethanolamine binding IDA--
    GO:0038023signaling receptor activity IDA16339535
         
    CD300A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd300a):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CD300A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd300atm1Shib for CD300A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD300A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD300A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD300A

    miRNA
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    miRTarBase miRNAs that target CD300A:
    hsa-mir-148b-3p (MIRT019435), hsa-mir-128-3p (MIRT022030)

    Block miRNA regulation of human, mouse, rat CD300A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD300A

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for CD300A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLM8_HUMAN, Q9UGN4: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane IDA10540326
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    CD300A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD300A
    Interactions:

        Search GeneGlobe Interaction Network for CD300A

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction IDA16339535
    GO:0030889negative regulation of B cell proliferation IMP--
    GO:0032516positive regulation of phosphoprotein phosphatase activity IDA16339535

    CD300A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD300A (CLM8)

    1 Novoseek inferred chemical compound relationship for CD300A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 29.1 2 17588661 (1), 10540326 (1)



    CD300A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD300A gene (2 alternative transcripts): 
    NM_001256841.1  NM_007261.3  

    Unigene Cluster for CD300A:

    CD300a molecule
    Hs.9688  [show with all ESTs]
    Unigene Representative Sequence: NM_007261
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360141(uc002jkv.3 uc002jkw.3 uc010dfr.3 uc010dfs.3)
    ENST00000392625 ENST00000361933 ENST00000310828 ENST00000582319 ENST00000577511

    miRNA
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    Block miRNA regulation of human, mouse, rat CD300A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD300A:
    hsa-miR-22 hsa-miR-198 hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD300A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD300A
    Predesigned siRNA for gene silencing in human, mouse, rat CD300A
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD300A
      QuantiTect SYBR Green Assays in human, mouse, rat CD300A
      QuantiFast Probe-based Assays in human, mouse, rat CD300A

    Additional mRNA sequence: 

    AF020314.1 AF161346.1 AJ010101.1 AJ010102.1 AJ010103.1 AJ224864.1 AJ238323.1 AK309631.1 
    AK309636.1 BC020681.1 BC032352.1 

    2 DOTS entries:

    DT.211864  DT.95168172 

    Selected AceView cDNA sequences (see all 80):

    BC032352 AJ010101 CB053994 BE858395 CA428265 BQ072616 AJ010103 AW475063 
    AJ010102 F08389 BQ072720 CR617958 AW103533 BM919189 CR616430 BX471149 
    AA047284 CD684484 AJ238323 BQ707716 BI820565 AL554086 AJ224864 AW593754 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD300A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:        -     -                     


    ECgene alternative splicing isoforms for CD300A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD300A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCAGAAC
    CD300A Expression
    About this image


    CD300A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    CD300A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD300A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9688

    UniProtKB/Swiss-Prot: CLM8_HUMAN, Q9UGN4
    Tissue specificity: Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic
    cells, mast cells, granulocytes and monocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD300A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd300a1 , 5 CD300A antigen1, 5 63.67(n)1
    48.2(a)1
      11 (80.54 cM)5
    2173031  NM_170758.31  NP_739564.11 
     1148900415 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    24(a)
    1 → many
    18(10693051-10694640)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    36(a)
    27(a)
    many ↔ many
    many ↔ many
    2(116020650-116030691)
    2(115986797-115996463)


    ENSEMBL Gene Tree for CD300A (if available)
    TreeFam Gene Tree for CD300A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD300A gene
    CD300LG2  CD300LB2  CD300C2  CD300LF2  CD300LD2  CD300E2  
    2 SIMAP similar genes for CD300A using alignment to 2 protein entries:     CLM8_HUMAN (see all proteins):
    CD300C    CD300E

    CD300A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD300A
    PGOHUM00000237176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD300A (see all 620)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379877511,2
    C--72460525(+) CTCACC/TGCAAC 2 -- us2k10--------
    rs1494718291,2
    --72460541(+) CCTCTC/TGAGTT 2 -- us2k10--------
    rs110777501,2
    C,F,A,H--72460549(+) GTTCAC/AGCGAT 2 -- us2k19Minor allele frequency- A:0.25NA WA CSA 20
    rs1867895281,2
    --72460734(+) CCCGGC/TCCGAA 2 -- us2k10--------
    rs80819991,2
    C,F--72460774(+) ATCTAT/GGACTG 2 -- us2k1 tfbs33Minor allele frequency- G:0.12NA WA 122
    rs1482448601,2
    --72460811(+) CCACCA/GGGCTT 2 -- us2k10--------
    rs126003511,2
    C,F,A,H--72460849(+) CCATAC/GGTCTC 2 -- us2k111Minor allele frequency- G:0.39NA WA CSA EA 372
    rs1429315201,2
    --72460871(+) GACACC/GTTCGT 2 -- us2k10--------
    rs1916590781,2
    --72460886(+) AAGGCA/GCCCCT 2 -- us2k10--------
    rs80783431,2
    C,F--72460904(+) GAAGGA/CAGAGG 2 -- us2k1 trp31Minor allele frequency- C:0.07WA 118

    HapMap Linkage Disequilibrium report for CD300A (72462522 - 72480933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CD300A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv12e196CNV Duplication17116639
    nsv470600CNV Loss18288195
    esv33995CNV Loss17666407
    nsv908741CNV Loss21882294
    esv2751770CNV Gain17911159
    dgv372n27CNV Gain19166990
    nsv517569CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD300A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606790    OMIM disorders: --

    6 diseases for CD300A:    
    About MalaCards
    psoriasis    tonsillitis    hepatitis b    ovarian cancer
    hepatitis    thyroiditis


    CD300A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD300A
    Human Genome Epidemiology (HuGE) Navigator: CD300A (2 documents)

    Export disorders for CD300A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD300A gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CD300A)
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    1. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PubMed id 10746781)1, 2, 3 Clark G.J.... Hart D.N.J. (Tissue Antigens 2000)
    2. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. (PubMed id 9701027)1, 2, 3 Green B.J.... Hart D.N.J. (Int. Immunol. 1998)
    3. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PubMed id 10540326)1, 2, 9 Cantoni C.... Moretta A. (Eur. J. Immunol. 1999)
    4. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. (PubMed id 16339535)1, 2, 9 Bachelet I.... Levi-Schaffer F. (J. Immunol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. (PubMed id 17588661)1, 9 Alvarez Y....Borrego F. (Mol. Immunol. 2008)
    7. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. (PubMed id 16254138)1, 9 Munitz A....Levi-Schaffer F. (Blood 2006)
    8. CD300a is expressed on human basophils and seems to inhibit IgE/FcI/RI-dependent anaphylactic degranulation. (PubMed id 22173928)1 Sabato V....Ebo D.G. (Cytometry B Clin Cytom 2012)
    9. Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a. (PubMed id 22537350)1 DeBell K.E....Borrego F. (BMC Immunol. 2012)
    10. Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor. (PubMed id 22185693)1 Nakahashi-Oda C....Shibuya A. (Biochem. Biophys. Res. Commun. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11314 HGNC: 19319 AceView: CMRF-35H Ensembl:ENSG00000167851 euGenes: HUgn11314
    ECgene: CD300A H-InvDB: CD300A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD300A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD300A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD300A gene:
    Search GeneIP for patents involving CD300A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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