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Aliases for CD300A Gene

Aliases for CD300A Gene

  • CD300a Molecule 2 3
  • CD300a Antigen 2 3 4
  • CMRF35H 3 4 6
  • Immunoglobulin Superfamily Member 12 3 4
  • CD300 Antigen-Like Family Member A 3 4
  • Inhibitory Receptor Protein 60 3 4
  • NK Inhibitory Receptor 3 4
  • CMRF-35-H9 3 4
  • CMRF35-H9 3 4
  • IRC1/IRC2 3 4
  • CMRF35H9 3 6
  • CMRF35-H 3 4
  • IGSF12 3 4
  • CLM-8 3 4
  • IRp60 3 4
  • CMRF35H Leukocyte Immunoglobulin-Like Receptor 3
  • Leukocyte Membrane Antigen 3
  • CMRF35-Like Molecule 8 3
  • CMRF-35H 3
  • IRC1 3
  • IRC2 3

External Ids for CD300A Gene

Previous GeneCards Identifiers for CD300A Gene

  • GC17P069975
  • GC17P072462
  • GC17P067871

Summaries for CD300A Gene

Entrez Gene Summary for CD300A Gene

  • This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CD300A Gene

CD300A (CD300a Molecule) is a Protein Coding gene. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot for CD300A Gene

  • Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.

Gene Wiki entry for CD300A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300A Gene

Genomics for CD300A Gene

Regulatory Elements for CD300A Gene

Genomic Location for CD300A Gene

74,466,374 bp from pter
74,484,798 bp from pter
18,425 bases
Plus strand

Genomic View for CD300A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300A Gene

Proteins for CD300A Gene

  • Protein details for CD300A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 8
    Protein Accession:
    Secondary Accessions:
    • A8MW96
    • O95100
    • Q9HD97
    • Q9P0F3
    • Q9UBK4
    • Q9UMS9
    • Q9UMT0

    Protein attributes for CD300A Gene

    299 amino acids
    Molecular mass:
    33201 Da
    Quaternary structure:
    • Upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 and PTPN11/SHP-2 and INPP5D
    • Sequence=AAF28906.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF28906.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD300A Gene

    Alternative splice isoforms for CD300A Gene


neXtProt entry for CD300A Gene

Proteomics data for CD300A Gene at MOPED

Post-translational modifications for CD300A Gene

Other Protein References for CD300A Gene

Antibody Products

  • R&D Systems Antibodies for CD300A (CD300a/LMIR1)

No data available for DME Specific Peptides for CD300A Gene

Domains for CD300A Gene

Gene Families for CD300A Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300A Gene

Suggested Antigen Peptide Sequences for CD300A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UGN4
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300A: view

Function for CD300A Gene

Molecular function for CD300A Gene

UniProtKB/Swiss-Prot Function:
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.

Gene Ontology (GO) - Molecular Function for CD300A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 22302738
GO:0005515 protein binding IPI 10540326
GO:0008429 phosphatidylethanolamine binding IDA 22302738
GO:0038023 signaling receptor activity IDA 16339535
genes like me logo Genes that share ontologies with CD300A: view
genes like me logo Genes that share phenotypes with CD300A: view

Animal Models for CD300A Gene

MGI Knock Outs for CD300A:

Animal Model Products

miRNA for CD300A Gene

miRTarBase miRNAs that target CD300A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD300A Gene

Localization for CD300A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD300A Gene COMPARTMENTS Subcellular localization image for CD300A gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD300A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 10540326
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CD300A: view

Pathways for CD300A Gene

SuperPathways for CD300A Gene

No Data Available

Interacting Proteins for CD300A Gene

Gene Ontology (GO) - Biological Process for CD300A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction IDA 16339535
GO:0030889 negative regulation of B cell proliferation IMP 21482706
GO:0032516 positive regulation of phosphoprotein phosphatase activity IDA 16339535
genes like me logo Genes that share ontologies with CD300A: view

No data available for Pathways by source for CD300A Gene

Compounds for CD300A Gene

(1) Novoseek inferred chemical compound relationships for CD300A Gene

Compound -log(P) Hits PubMed IDs
tyrosine 29.1 2
genes like me logo Genes that share compounds with CD300A: view

Transcripts for CD300A Gene

Unigene Clusters for CD300A Gene

CD300a molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: - -

Relevant External Links for CD300A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300A Gene

mRNA expression in normal human tissues for CD300A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300A Gene

This gene is overexpressed in Whole Blood (28.7) and Spleen (5.6).

Protein differential expression in normal tissues for CD300A Gene

This gene is overexpressed in Urine (42.0) and Monocytes (13.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300A Gene

SOURCE GeneReport for Unigene cluster for CD300A Gene Hs.9688

mRNA Expression by UniProt/SwissProt for CD300A Gene

Tissue specificity: Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
genes like me logo Genes that share expressions with CD300A: view

Expression partners for CD300A Gene

In Situ Assay Products

Orthologs for CD300A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD300A 35
  • 66.43 (n)
  • 53.02 (a)
-- 36
  • 36 (a)
-- 36
  • 47 (a)
(Canis familiaris)
Mammalia CD300A 35
  • 69.63 (n)
  • 58.15 (a)
-- 36
  • 37 (a)
-- 36
  • 40 (a)
(Mus musculus)
Mammalia Cd300a 35
  • 63.67 (n)
  • 48.2 (a)
Cd300a 16
AF251705 36
  • 34 (a)
Cd300a 36
  • 38 (a)
Cd300c 36
  • 37 (a)
(Pan troglodytes)
Mammalia CD300A 35
  • 98.14 (n)
  • 95.82 (a)
CD300A 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Cd300a 35
  • 65.2 (n)
  • 54.95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
-- 36
  • 44 (a)
-- 36
  • 33 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
(Gallus gallus)
Aves -- 36
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
-- 36
  • 36 (a)
Species with no ortholog for CD300A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300A Gene

Gene Tree for CD300A (if available)
Gene Tree for CD300A (if available)

Paralogs for CD300A Gene

Paralogs for CD300A Gene

Selected SIMAP similar genes for CD300A Gene using alignment to 2 proteins: Pseudogenes for CD300A Gene

genes like me logo Genes that share paralogs with CD300A: view

Variants for CD300A Gene

Sequence variations from dbSNP and Humsavar for CD300A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1044282 -- 74,484,366(+) CTGTC(A/G)CCTCT utr-variant-3-prime, downstream-variant-500B
rs1127737 -- 74,473,819(+) ACACC(A/C/G)TGGCT intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1533898 -- 74,475,539(+) TCGGG(G/T)TCACC intron-variant
rs1533899 -- 74,475,735(+) cacaa(A/G)accgc intron-variant
rs1879967 -- 74,481,246(+) TGGCC(A/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300A Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv908741 CNV Loss 21882294
nsv470600 CNV Loss 18288195

Relevant External Links for CD300A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300A Gene

Disorders for CD300A Gene

Relevant External Links for CD300A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CD300A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CD300A Gene

Publications for CD300A Gene

  1. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. (PMID: 10540326) Cantoni C. … Moretta A. (Eur. J. Immunol. 1999) 3 4 23
  2. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. (PMID: 16339535) Bachelet I. … Levi-Schaffer F. (J. Immunol. 2005) 3 4 23
  3. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. (PMID: 9701027) Green B.J. … Hart D.N.J. (Int. Immunol. 1998) 2 3 4
  4. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. (PMID: 10746781) Clark G.J. … Hart D.N.J. (Tissue Antigens 2000) 2 3 4
  5. The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. (PMID: 17588661) Alvarez Y. … Borrego F. (Mol. Immunol. 2008) 3 23

Products for CD300A Gene

Sources for CD300A Gene

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