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Aliases for CD2BP2 Gene

Aliases for CD2BP2 Gene

  • CD2 (Cytoplasmic Tail) Binding Protein 2 2 3
  • CD2 Cytoplasmic Domain-Binding Protein 2 3 4
  • U5 SnRNP 52K Protein 3 4
  • U5-52K 3 4
  • CD2 Antigen (Cytoplasmic Tail)-Binding Protein 2 2
  • CD2 Antigen (Cytoplasmic Tail) Binding Protein 2 3
  • CD2 Antigen Cytoplasmic Tail-Binding Protein 2 3
  • Protein Phosphatase 1, Regulatory Subunit 59 3
  • CD2 Tail-Binding Protein 2 4
  • Protein Phosphatase 1 2
  • Regulatory Subunit 59 2
  • KIAA1178 4
  • PPP1R59 3
  • FWP010 3
  • Snu40 3
  • LIN1 3

External Ids for CD2BP2 Gene

Previous GeneCards Identifiers for CD2BP2 Gene

  • GC16P029473
  • GC16M030756
  • GC16M030359
  • GC16M030400
  • GC16M030272
  • GC16M030273
  • GC16M027924

Summaries for CD2BP2 Gene

Entrez Gene Summary for CD2BP2 Gene

  • This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for CD2BP2 Gene

CD2BP2 (CD2 (Cytoplasmic Tail) Binding Protein 2) is a Protein Coding gene. Diseases associated with CD2BP2 include contagious pustular dermatitis and lobular neoplasia. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for CD2BP2 Gene

  • Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Gene Wiki entry for CD2BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2BP2 Gene

Genomics for CD2BP2 Gene

Regulatory Elements for CD2BP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD2BP2 Gene

Start:
30,350,766 bp from pter
End:
30,355,361 bp from pter
Size:
4,596 bases
Orientation:
Minus strand

Genomic View for CD2BP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD2BP2 Gene

Proteins for CD2BP2 Gene

  • Protein details for CD2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95400-CD2B2_HUMAN
    Recommended name:
    CD2 antigen cytoplasmic tail-binding protein 2
    Protein Accession:
    O95400
    Secondary Accessions:
    • B2RDX2
    • Q9ULP2

    Protein attributes for CD2BP2 Gene

    Size:
    341 amino acids
    Molecular mass:
    37646 Da
    Quaternary structure:
    • Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.

    Three dimensional structures from OCA and Proteopedia for CD2BP2 Gene

neXtProt entry for CD2BP2 Gene

Proteomics data for CD2BP2 Gene at MOPED

Post-translational modifications for CD2BP2 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for CD2BP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD2BP2 Gene

Domains for CD2BP2 Gene

Gene Families for CD2BP2 Gene

Protein Domains for CD2BP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD2BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95400

UniProtKB/Swiss-Prot:

CD2B2_HUMAN :
  • Contains 1 GYF domain.
Domain:
  • Contains 1 GYF domain.
genes like me logo Genes that share domains with CD2BP2: view

Function for CD2BP2 Gene

Molecular function for CD2BP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Gene Ontology (GO) - Molecular Function for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840814
GO:0043021 ribonucleoprotein complex binding IDA 15840814
genes like me logo Genes that share ontologies with CD2BP2: view

Phenotypes for CD2BP2 Gene

genes like me logo Genes that share phenotypes with CD2BP2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD2BP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CD2BP2 Gene

Localization for CD2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD2BP2 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD2BP2 Gene COMPARTMENTS Subcellular localization image for CD2BP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15840814
GO:0005654 nucleoplasm TAS --
GO:0005682 U5 snRNP IDA 15840814
GO:0005737 cytoplasm IDA --
GO:0016607 colocalizes_with nuclear speck IDA 15840814
genes like me logo Genes that share ontologies with CD2BP2: view

Pathways for CD2BP2 Gene

genes like me logo Genes that share pathways with CD2BP2: view

Pathways by source for CD2BP2 Gene

Gene Ontology (GO) - Biological Process for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 15840814
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CD2BP2: view

Transcripts for CD2BP2 Gene

Unigene Clusters for CD2BP2 Gene

CD2 (cytoplasmic tail) binding protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD2BP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD2BP2 Gene

No ASD Table

Relevant External Links for CD2BP2 Gene

GeneLoc Exon Structure for
CD2BP2
ECgene alternative splicing isoforms for
CD2BP2

Expression for CD2BP2 Gene

mRNA expression in normal human tissues for CD2BP2 Gene

Protein differential expression in normal tissues for CD2BP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD2BP2 Gene

SOURCE GeneReport for Unigene cluster for CD2BP2 Gene Hs.202677

genes like me logo Genes that share expressions with CD2BP2: view

Expression partners for CD2BP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD2BP2 Gene

Orthologs for CD2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD2BP2 35
  • 89.31 (n)
  • 90.88 (a)
CD2BP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD2BP2 35
  • 87.75 (n)
  • 89.71 (a)
CD2BP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd2bp2 35
  • 86.18 (n)
  • 89.71 (a)
Cd2bp2 16
Cd2bp2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd2bp2 35
  • 86.04 (n)
  • 89.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CD2BP2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD2BP2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD2BP2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD2BP2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clip4 35
  • 64.51 (n)
  • 62.8 (a)
MGC76157 35
African clawed frog
(Xenopus laevis)
Amphibia cd2bp2-prov 35
zebrafish
(Danio rerio)
Actinopterygii cd2bp2 35
  • 55.99 (n)
  • 51.06 (a)
zgc56165 35
cd2bp2 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5198 37
  • 34 (a)
holn1 35
  • 47.82 (n)
  • 35.96 (a)
holn1 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011494 35
  • 50.72 (n)
  • 36.96 (a)
worm
(Caenorhabditis elegans)
Secernentea teg-1 35
  • 44.49 (n)
  • 34.68 (a)
teg-1 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4310 36
  • 34 (a)
OneToOne
Species with no ortholog for CD2BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD2BP2 Gene

ENSEMBL:
Gene Tree for CD2BP2 (if available)
TreeFam:
Gene Tree for CD2BP2 (if available)

Paralogs for CD2BP2 Gene

Pseudogenes.org Pseudogenes for CD2BP2 Gene

genes like me logo Genes that share paralogs with CD2BP2: view

No data available for Paralogs for CD2BP2 Gene

Variants for CD2BP2 Gene

Sequence variations from dbSNP and Humsavar for CD2BP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_050773 -
VAR_050772 -
rs578153204 -- 30,352,065(+) GCCAC(C/G)AGACT utr-variant-3-prime
rs576302484 -- 30,350,573(+) CCAAG(A/G)AGTGC downstream-variant-500B
rs576091313 -- 30,352,106(+) ACCTC(A/G)GTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD2BP2 Gene

Variant ID Type Subtype PubMed ID
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850

Relevant External Links for CD2BP2 Gene

HapMap Linkage Disequilibrium report
CD2BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD2BP2 Gene

Disorders for CD2BP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD2BP2 Gene in MalaCards »

(2) Diseases for CD2BP2 Gene

(2) University of Copenhagen DISEASES for CD2BP2 Gene

genes like me logo Genes that share disorders with CD2BP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CD2BP2 Gene

Publications for CD2BP2 Gene

  1. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. (PMID: 15840814) Laggerbauer B. … Luhrmann R. (RNA 2005) 3 4 23
  2. Investigating the functional role of CD2BP2 in T cells. (PMID: 17906334) Heinze M. … Freund C. (Int. Immunol. 2007) 3 4 23
  3. Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. (PMID: 9843987) Nishizawa K. … Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  4. The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. (PMID: 10404223) Freund C. … Wagner G. (Nat. Struct. Biol. 1999) 3 4
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4

Products for CD2BP2 Gene

Sources for CD2BP2 Gene

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