Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD2BP2 Gene

Aliases for CD2BP2 Gene

  • CD2 Cytoplasmic Tail Binding Protein 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 59 2 3
  • CD2 Cytoplasmic Domain-Binding Protein 2 3 4
  • U5 SnRNP 52K Protein 3 4
  • U5-52K 3 4
  • CD2 Antigen (Cytoplasmic Tail)-Binding Protein 2 2
  • CD2 Antigen Cytoplasmic Tail-Binding Protein 2 3
  • CD2 (Cytoplasmic Tail) Binding Protein 2 2
  • CD2 Tail-Binding Protein 2 4
  • KIAA1178 4
  • PPP1R59 3
  • FWP010 3
  • Snu40 3
  • LIN1 3

External Ids for CD2BP2 Gene

Previous GeneCards Identifiers for CD2BP2 Gene

  • GC16P029473
  • GC16M030756
  • GC16M030359
  • GC16M030400
  • GC16M030272
  • GC16M030273
  • GC16M027924

Summaries for CD2BP2 Gene

Entrez Gene Summary for CD2BP2 Gene

  • This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for CD2BP2 Gene

CD2BP2 (CD2 Cytoplasmic Tail Binding Protein 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for CD2BP2 Gene

  • Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Gene Wiki entry for CD2BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2BP2 Gene

Genomics for CD2BP2 Gene

Regulatory Elements for CD2BP2 Gene

Enhancers for CD2BP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F029942 1.7 FANTOM5 Ensembl ENCODE 24.6 +411.4 411379 3.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF207 FOS ENSG00000260853 MIR4517 SMG1P2 INO80E ENSG00000260367 ZNF785 CD2BP2 CDIPT NPIPB13 ENSG00000247735
GH16F030089 1.2 ENCODE 24.6 +261.9 261869 8.1 CREB3L1 MLX DMAP1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 SMG1P2 YPEL3 ZNF764 ZNF785 CD2BP2 TBX6 BCL7C PRR14 ORAI3 MIR762HG
GH16F029862 1.2 ENCODE 24.6 +492.2 492239 2.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CDIPT-AS1 ZNF785 CD2BP2 ENSG00000261766 ENSG00000260114 DOC2A TMEM219 MAZ ENSG00000278713
GH16F030538 1.3 Ensembl ENCODE 20.6 -186.0 -186041 5.3 PKNOX1 ATF1 ARNT MLX ARID4B DMAP1 ZNF48 ZNF121 ZNF302 FOS ZNF764 ZNF785 CD2BP2 ENSG00000235560 SMG1P2 ENSG00000260267 ENSG00000260304 ENSG00000239791 ZNF688 BCL7C
GH16F029783 1.6 FANTOM5 Ensembl ENCODE 15.3 +570.8 570777 2.8 PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 CBX5 ZNF143 KLF13 MXD4 C16orf92 CD2BP2 ZNF785 KIF22 ENSG00000261766 ENSG00000260114 GDPD3 TBX6 MYLPF KCTD13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD2BP2 on UCSC Golden Path with GeneCards custom track

Promoters for CD2BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CD2BP2 Gene

30,350,766 bp from pter
30,355,361 bp from pter
4,596 bases
Minus strand

Genomic View for CD2BP2 Gene

Genes around CD2BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD2BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD2BP2 Gene

Proteins for CD2BP2 Gene

  • Protein details for CD2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD2 antigen cytoplasmic tail-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RDX2
    • Q9ULP2

    Protein attributes for CD2BP2 Gene

    341 amino acids
    Molecular mass:
    37646 Da
    Quaternary structure:
    • Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.

    Three dimensional structures from OCA and Proteopedia for CD2BP2 Gene

neXtProt entry for CD2BP2 Gene

Post-translational modifications for CD2BP2 Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Other Protein References for CD2BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD2BP2 Gene

Domains & Families for CD2BP2 Gene

Gene Families for CD2BP2 Gene

Protein Domains for CD2BP2 Gene


Suggested Antigen Peptide Sequences for CD2BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GYF domain.
  • Contains 1 GYF domain.
genes like me logo Genes that share domains with CD2BP2: view

Function for CD2BP2 Gene

Molecular function for CD2BP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Gene Ontology (GO) - Molecular Function for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9843987
GO:0043021 ribonucleoprotein complex binding IDA 15840814
genes like me logo Genes that share ontologies with CD2BP2: view

Phenotypes for CD2BP2 Gene

genes like me logo Genes that share phenotypes with CD2BP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD2BP2 Gene

Localization for CD2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD2BP2 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD2BP2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15840814
GO:0005654 nucleoplasm IDA,TAS --
GO:0005682 U5 snRNP IDA 15840814
GO:0005737 cytoplasm IDA --
GO:0016607 colocalizes_with nuclear speck IDA 15840814
genes like me logo Genes that share ontologies with CD2BP2: view

Pathways & Interactions for CD2BP2 Gene

genes like me logo Genes that share pathways with CD2BP2: view

Pathways by source for CD2BP2 Gene

Gene Ontology (GO) - Biological Process for CD2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 15840814
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CD2BP2: view

No data available for SIGNOR curated interactions for CD2BP2 Gene

Transcripts for CD2BP2 Gene

Unigene Clusters for CD2BP2 Gene

CD2 (cytoplasmic tail) binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD2BP2 Gene

No ASD Table

Relevant External Links for CD2BP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD2BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD2BP2 Gene

Protein differential expression in normal tissues from HIPED for CD2BP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD2BP2 Gene

Protein tissue co-expression partners for CD2BP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD2BP2 Gene:


SOURCE GeneReport for Unigene cluster for CD2BP2 Gene:

genes like me logo Genes that share expression patterns with CD2BP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD2BP2 Gene

Orthologs for CD2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD2BP2 35
  • 96 (a)
(Bos Taurus)
Mammalia CD2BP2 34 35
  • 89.31 (n)
(Canis familiaris)
Mammalia CD2BP2 34 35
  • 87.75 (n)
(Mus musculus)
Mammalia Cd2bp2 34 16 35
  • 86.18 (n)
(Rattus norvegicus)
Mammalia Cd2bp2 34
  • 86.04 (n)
(Monodelphis domestica)
Mammalia CD2BP2 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CD2BP2 35
  • 73 (a)
(Anolis carolinensis)
Reptilia CD2BP2 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clip4 34
  • 64.51 (n)
MGC76157 34
African clawed frog
(Xenopus laevis)
Amphibia cd2bp2-prov 34
(Danio rerio)
Actinopterygii cd2bp2 34 35
  • 55.99 (n)
zgc56165 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011494 34
  • 50.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta holn1 34 35
  • 47.82 (n)
CG5198 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea teg-1 34 35
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4310 35
  • 34 (a)
Species where no ortholog for CD2BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD2BP2 Gene

Gene Tree for CD2BP2 (if available)
Gene Tree for CD2BP2 (if available)

Paralogs for CD2BP2 Gene Pseudogenes for CD2BP2 Gene

genes like me logo Genes that share paralogs with CD2BP2: view

No data available for Paralogs for CD2BP2 Gene

Variants for CD2BP2 Gene

Sequence variations from dbSNP and Humsavar for CD2BP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111799648 -- 30,354,262(+) ATCCA(A/G)AGAGT upstream-variant-2KB, reference, synonymous-codon
rs112076901 -- 30,350,772(+) GAGAG(A/G)TTGAA utr-variant-3-prime
rs112131146 -- 30,355,249(+) GAAGA(C/G)ATGCT upstream-variant-2KB, utr-variant-5-prime
rs112470376 -- 30,355,244(+) AAAAA(C/G)AAGAG upstream-variant-2KB, utr-variant-5-prime
rs1127447 -- 30,357,171(-) ACATT(C/T)TCTTC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD2BP2 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850

Variation tolerance for CD2BP2 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD2BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD2BP2 Gene

Disorders for CD2BP2 Gene

Relevant External Links for CD2BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CD2BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD2BP2 Gene

Publications for CD2BP2 Gene

  1. Investigating the functional role of CD2BP2 in T cells. (PMID: 17906334) Heinze M. … Freund C. (Int. Immunol. 2007) 3 4 22 64
  2. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. (PMID: 15840814) Laggerbauer B. … Luhrmann R. (RNA 2005) 3 4 22 64
  3. Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. (PMID: 9843987) Nishizawa K. … Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  4. Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). (PMID: 17467737) Nielsen T.K. … Ficner R. (J. Mol. Biol. 2007) 3 4 64
  5. Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library. (PMID: 16941565) Monos D. … Kamoun M. (J. Mol. Recognit. 2006) 3 22 64

Products for CD2BP2 Gene

Sources for CD2BP2 Gene

Loading form....