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CD2BP2 Gene

protein-coding   GIFtS: 59
GCID: GC16M030363

CD2 (Cytoplasmic Tail) Binding Protein 2

(Previous name: CD2 antigen (cytoplasmic tail)-binding protein 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD2 (Cytoplasmic Tail) Binding Protein 21 2     LIN12
U5-52K2 3     PPP1R592
CD2 Cytoplasmic Domain-Binding Protein 22 3     Snu402
U5 SnRNP 52K Protein2 3     CD2 Antigen (Cytoplasmic Tail) Binding Protein 22
CD2 Antigen (Cytoplasmic Tail)-Binding Protein 21     CD2 Antigen Cytoplasmic Tail-Binding Protein 22
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 592
Regulatory Subunit 591     KIAA11783
FWP0102     CD2 Tail-Binding Protein 23

External Ids:    HGNC: 16561   Entrez Gene: 104212   Ensembl: ENSG000001692177   OMIM: 6044705   UniProtKB: O954003   

Export aliases for CD2BP2 gene to outside databases

Previous GC identifers: GC16P029473 GC16M030756 GC16M030359 GC16M030400 GC16M030272 GC16M030273 GC16M027924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD2BP2 Gene:
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of
human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In
the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA
splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript
variants but their biological validity has not been determined. (provided by RefSeq, Nov 2008)

GeneCards Summary for CD2BP2 Gene:
CD2BP2 (CD2 (cytoplasmic tail) binding protein 2) is a protein-coding gene. Diseases associated with CD2BP2 include spondylolysis, and contagious pustular dermatitis. GO annotations related to this gene include ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot: CD2B2_HUMAN, O95400
Function: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome
assembly

Gene Wiki entry for CD2BP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD2BP2 gene promoter:
         p53   FOXJ2 (long isoform)   HFH-1   FOXJ2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD2BP2 promoter sequence
   Search Chromatin IP Primers for CD2BP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD2BP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

CD2BP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD2BP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030363:  view genomic region     (about GC identifiers)

Start:
30,362,087 bp from pter      End:
30,366,682 bp from pter
Size:
4,596 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD2B2_HUMAN, O95400 (See protein sequence)
Recommended Name: CD2 antigen cytoplasmic tail-binding protein 2  
Size: 341 amino acids; 37646 Da
Subunit: Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2,
SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2
(via Pro-rich sequence in the cytoplasmic domain)
3 PDB 3D structures from and Proteopedia for CD2BP2:
1GYF (3D)        1L2Z (3D)        1SYX (3D)    
Secondary accessions: B2RDX2 Q9ULP2

Explore the universe of human proteins at neXtProt for CD2BP2: NX_O95400

Explore proteomics data for CD2BP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127
  • Modification sites at PhosphoSitePlus

  • See CD2BP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230575.1  NP_006101.1  

    ENSEMBL proteins: 
     ENSP00000304903   ENSP00000456935  
    Reactome Protein details: O95400

    CD2BP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR003169 GYF

    Graphical View of Domain Structure for InterPro Entry O95400

    ProtoNet protein and cluster: O95400

    1 Blocks protein domain: IPB003169 CD2-binding protein

    UniProtKB/Swiss-Prot: CD2B2_HUMAN, O95400
    Similarity: Contains 1 GYF domain


    CD2BP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD2B2_HUMAN, O95400
    Function: Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome
    assembly

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15840814
    GO:0043021ribonucleoprotein complex binding IDA15840814
         
    CD2BP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CD2BP2:
     Increased HPV18 LCR reporter a  Increased cell number in S  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD2BP2
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    miRNA
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    miRTarBase miRNAs that target CD2BP2:
    hsa-mir-124-3p (MIRT022522), hsa-mir-3679-3p (MIRT052875), hsa-mir-92a-3p (MIRT049524), hsa-mir-484 (MIRT042172), hsa-mir-615-3p (MIRT039811), hsa-let-7b-5p (MIRT051962)

    Block miRNA regulation of human, mouse, rat CD2BP2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CD2BP2:
    hsa-miR-600 hsa-miR-3154 hsa-miR-3202 hsa-miR-3065-3p hsa-miR-3119 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCD2BP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD2B2_HUMAN, O95400: Cytoplasm. Nucleus. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005682U5 snRNP IDA15840814
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CD2BP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD2BP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD2BP2
        mRNA processing

    1 Reactome Pathway for CD2BP2
        mRNA Splicing - Major Pathway



    CD2BP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD2BP2
    Interactions:

        GeneGlobe Interaction Network for CD2BP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD2BP2 (O954001, 2, 3 ENSP000003049034) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2P067291, 2, 3, ENSP000003584904EBI-768015,EBI-3912464 MINT-50471 MINT-50457 MINT-15125 MINT-62665 MINT-50559 MINT-62656 MINT-62832 MINT-18223 MINT-62660 MINT-62648 MINT-62661 MINT-50473 MINT-50470 MINT-62666 MINT-50472 MINT-62819 I2D: score=4 STRING: ENSP00000358490
    SNRPBP146782, 3, ENSP000004125664MINT-62827 MINT-62831 MINT-62664 MINT-62853 MINT-62655 MINT-62852 MINT-62851 MINT-62850 MINT-62849 MINT-62833 MINT-62652 I2D: score=2 STRING: ENSP00000412566
    PRPF6O949061, 2, 3, ENSP000002660794EBI-768015,EBI-536755 MINT-1783290 MINT-8331580 MINT-1783311 MINT-8336155 I2D: score=4 STRING: ENSP00000266079
    TXNL4AP838761, 2, 3, ENSP000002696014EBI-768015,EBI-746539 MINT-1783335 MINT-1783263 I2D: score=3 STRING: ENSP00000269601
    SNRPNP631622, 3MINT-62854 MINT-62855 MINT-62856 MINT-62857 MINT-62858 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000244spliceosomal tri-snRNP complex assembly NAS15840814
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0010923negative regulation of phosphatase activity IDA19389623

    CD2BP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD2BP2 (CD2B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD2BP2 gene (2 alternative transcripts): 
    NM_001243646.1  NM_006110.2  

    Unigene Cluster for CD2BP2:

    CD2 (cytoplasmic tail) binding protein 2
    Hs.202677  [show with all ESTs]
    Unigene Representative Sequence: NM_001243646
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305596(uc002dxr.3 uc002dxs.3) ENST00000569466 ENST00000564525

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CD2BP2:
    hsa-miR-600 hsa-miR-3154 hsa-miR-3202 hsa-miR-3065-3p hsa-miR-3119 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidCD2BP2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CD2BP2
      QuantiFast Probe-based Assays in human, mouse, rat CD2BP2

    Additional mRNA sequence: 

    AB033004.1 AF104222.1 AF109192.1 AK315708.1 BC000495.2 BC001947.1 BC013854.1 BC106082.1 

    10 DOTS entries:

    DT.85105505  DT.101980916  DT.100802596  DT.92450554  DT.92450563  DT.100802604  DT.92450550  DT.97853338 
    DT.121105972  DT.97767487 

    Selected AceView cDNA sequences (see all 393):

    CD671217 AA402090 BM449488 Z44337 AI802674 BM804989 AW514348 BU902115 
    BQ636685 BG005253 BG928129 BM709133 BE258188 BM705453 BQ688162 BC000495 
    BQ646685 BQ932883 BQ685375 CR613917 BU740303 BQ227884 AI289600 CA943698 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD2BP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCAAGGAA
    CD2BP2 Expression
    About this image

    CD2BP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD2BP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202677
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD2BP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2bp21 , 5 CD2 antigen (cytoplasmic tail) binding protein 21, 5 86.18(n)1
    89.71(a)1
      7 (69.38 cM)5
    702331  NM_001285905.11  NP_001272834.11 
     1271916605 
    lizard
    (Anolis carolinensis)
    Reptilia CD2BP26
    CD2 (cytoplasmic tail) binding protein 2
    60(a)
    1 ↔ 1
    GL343516.1(352103-356354)
    African clawed frog
    (Xenopus laevis)
    Amphibia cd2bp2-prov2 CD2 antigen (cytoplasmic tail) binding protein 2 79.09(n)    BC045270.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561652 similar to CD2 antigen (cytoplasmic tail) binding protein more 77.02(n)   393936  BC045960.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51983
    holn11
    hole-in-one1 34(a)3
    47.82(n)1
    35.96(a)1
      31E23
    344321  NM_135560.31  NP_609404.21 
    worm
    (Caenorhabditis elegans)
    Secernentea teg-11 teg-1 44.49(n)
    34.68(a)
      176561  NM_067054.5  NP_499455.2 


    ENSEMBL Gene Tree for CD2BP2 (if available)
    TreeFam Gene Tree for CD2BP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD2BP2 gene

    CD2BP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD2BP2
    PGOHUM00000232982


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD2BP2 (see all 156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862262501,2
    --30361719(+) TGCACA/TCCTGT 2 -- ds50010--------
    rs1143883821,2
    C,F--30361990(+) CACAGG/CAAGGG 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs563530631,2
    C,F--30361995(+) GAAGGG/CAGAAC 2 -- ds50013Minor allele frequency- C:0.29NA 124
    rs1925047571,2
    --30362012(+) AGATCA/GGGTGG 2 -- ds50010--------
    rs1807932001,2
    --30362157(+) TTTCAA/CCAGGC 2 -- ut310--------
    rs773776581,2
    F--30362315(+) CAGACC/GCTCGT 2 -- ut310--------
    rs1456363941,2
    --30362334(+) TTCCCC/TTATAA 2 -- ut310--------
    rs1171957191,2
    F--30362637(+) ACGCAC/TGCACT 2 -- ut311Minor allele frequency- T:0.01EA 120
    rs800006931,2
    C,F--30362813(+) AGGAAG/AGTATC 2 -- ut311Minor allele frequency- A:0.24EA 120
    rs1862299371,2
    --30362973(+) AGTGTC/TCTGCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CD2BP2 (30362087 - 30366682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD2BP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv847e1CNV Complex17122850
    dgv846e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604470    OMIM disorders: --

    8 diseases for CD2BP2:    About MalaCards
    spondylolysis    contagious pustular dermatitis    lobular neoplasia    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    dermatitis    malaria    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for CD2BP2:
    Lobular neoplasia     Contagious pustular dermatitis

    CD2BP2 for disorders           About GeneDecksing


    Export disorders for CD2BP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD2BP2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CD2BP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. (PubMed id 9843987)1, 2, 3 Nishizawa K.... Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Investigating the functional role of CD2BP2 in T cells. (PubMed id 17906334)1, 2, 9 Heinze M.... Freund C. (Int. Immunol. 2007)
    3. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. (PubMed id 15840814)1, 2, 9 Laggerbauer B.... Luhrmann R. (RNA 2005)
    4. Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). (PubMed id 17467737)1, 2 Nielsen T.K.... Ficner R. (J. Mol. Biol. 2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. (PubMed id 12426371)1, 2 Freund C.... Wagner G. (EMBO J. 2002)
    8. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    9. The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. (PubMed id 10404223)1, 2 Freund C.... Wagner G. (Nat. Struct. Biol. 1999)
    10. Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2. (PubMed id 15105431)1, 9 Kofler M....Freund C. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10421 HGNC: 1656 AceView: CD2BP2 Ensembl:ENSG00000169217 euGenes: HUgn10421
    ECgene: CD2BP2 H-InvDB: CD2BP2

    (According to HUGE)
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    HUGE: KIAA1178

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD2BP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD2BP2 gene:
    Search GeneIP for patents involving CD2BP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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