Aliases for CD28 Gene
External Ids for CD28 Gene
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for CD28 Gene
CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include sialadenitis and common variable immunodeficiency. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.
UniProtKB/Swiss-Prot for CD28 Gene
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival