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Aliases for CD28 Gene

Aliases for CD28 Gene

  • CD28 Molecule 2 3 5
  • CD28 Antigen 3 4
  • Tp44 3 4
  • T-Cell-Specific Surface Glycoprotein CD28 3
  • T-Cell-Specific Surface Glycoprotein 2
  • CD28 Antigen (Tp44) 2

External Ids for CD28 Gene

Previous GeneCards Identifiers for CD28 Gene

  • GC02P202788
  • GC02P203295
  • GC02P204535
  • GC02P204773
  • GC02P204396
  • GC02P204279
  • GC02P196418

Summaries for CD28 Gene

Entrez Gene Summary for CD28 Gene

  • The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for CD28 Gene

CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Sezary's Disease and Mycosis Fungoides. Among its related pathways are RET signaling and CD28 co-stimulation. GO annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.

UniProtKB/Swiss-Prot for CD28 Gene

  • Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Gene Wiki entry for CD28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD28 Gene

Genomics for CD28 Gene

Regulatory Elements for CD28 Gene

Enhancers for CD28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F203737 1.3 FANTOM5 Ensembl ENCODE 28.8 +34.9 34941 7.2 ZNF263 GATA3 CEBPB ZKSCAN1 NR2F2 CD28 KRT18P39 ICOS RNU6-474P RAPH1 CTLA4
GH02F203704 1.1 FANTOM5 ENCODE 23.6 +1.6 1588 7.8 PKNOX1 USF1 TBL1XR1 CEBPG BMI1 RELA FOSL1 POLR2A ZNF366 CBX5 ICOS CTLA4 CD28 RNU6-474P NBEAL1 KRT18P39 LOC100419679
GH02F203730 0.6 Ensembl ENCODE 15.8 +25.7 25684 3.7 E2F1 GATA3 POLR2A FOXA3 JUNB REST CD28 RAPH1 RNU6-474P KRT18P39
GH02F204023 0.7 FANTOM5 15.2 +316.8 316822 0.1 ICOS CTLA4 CD28 GC02P204020 LOC100419685
GH02F203717 1 FANTOM5 Ensembl ENCODE 15 +13.8 13762 6.2 SOX13 ELF3 PKNOX1 USF1 TAL1 MAX ZIC2 RARA FOS GATAD2A CD28 ICOS RAPH1 RNU6-474P KRT18P39 CTLA4 CARF CYP20A1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD28 on UCSC Golden Path with GeneCards custom track

Promoters for CD28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001831587 1625 3401 PKNOX1 USF1 TBL1XR1 CEBPG BMI1 RELA POLR2A CBX5 CREM CHD2

Genomic Location for CD28 Gene

Chromosome:
2
Start:
203,706,475 bp from pter
End:
203,738,912 bp from pter
Size:
32,438 bases
Orientation:
Plus strand

Genomic View for CD28 Gene

Genes around CD28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD28 Gene

Proteins for CD28 Gene

  • Protein details for CD28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10747-CD28_HUMAN
    Recommended name:
    T-cell-specific surface glycoprotein CD28
    Protein Accession:
    P10747
    Secondary Accessions:
    • A8KAC1
    • Q13964
    • Q52M23
    • Q70WG0
    • Q8NI54
    • Q8NI55
    • Q8NI56
    • Q8WXJ2
    • Q9BYV0

    Protein attributes for CD28 Gene

    Size:
    220 amino acids
    Molecular mass:
    25066 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2. Isoform 3 interacts with CD40LG (PubMed:15067037).

    Three dimensional structures from OCA and Proteopedia for CD28 Gene

    Alternative splice isoforms for CD28 Gene

neXtProt entry for CD28 Gene

Post-translational modifications for CD28 Gene

  • CD40LG induces tyrosine phosphorylation of isoform 3.
  • Glycosylation at Asn 37, Asn 71, Asn 92, Asn 105, and Asn 129
  • Modification sites at PhosphoSitePlus

Other Protein References for CD28 Gene

No data available for DME Specific Peptides for CD28 Gene

Domains & Families for CD28 Gene

Gene Families for CD28 Gene

Protein Domains for CD28 Gene

Suggested Antigen Peptide Sequences for CD28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10747

UniProtKB/Swiss-Prot:

CD28_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD28: view

Function for CD28 Gene

Molecular function for CD28 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD28 (Tp44),44kDa,identified by monoclonal antibody 9.3,KOLT2,expressed in T lymphocyte,CD80,CD86 ligand,stimulating PDE7 for T cell activation,regulated by CBLB
UniProtKB/Swiss-Prot Function:
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Gene Ontology (GO) - Molecular Function for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005070 SH3/SH2 adaptor activity IDA 19641626
GO:0005515 protein binding IPI 7568038
GO:0015026 coreceptor activity TAS 9784967
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CD28: view
genes like me logo Genes that share phenotypes with CD28: view

Animal Models for CD28 Gene

MGI Knock Outs for CD28:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD28

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD28 Gene

Localization for CD28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD28 Gene

Membrane; Single-pass type I membrane protein.
Isoform 3: Cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD28 Gene COMPARTMENTS Subcellular localization image for CD28 gene
Compartment Confidence
cytosol 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 9784967
GO:0009897 external side of plasma membrane IDA 11390434
genes like me logo Genes that share ontologies with CD28: view

Pathways & Interactions for CD28 Gene

genes like me logo Genes that share pathways with CD28: view

SIGNOR curated interactions for CD28 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002863 positive regulation of inflammatory response to antigenic stimulus IEA --
GO:0006955 immune response IEA --
GO:0006959 humoral immune response TAS 8717514
GO:0007166 cell surface receptor signaling pathway TAS 9784967
GO:0010628 positive regulation of gene expression IMP 23817958
genes like me logo Genes that share ontologies with CD28: view

Drugs & Compounds for CD28 Gene

(34) Drugs for CD28 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1113,1113
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2829
Vidarabine Approved Pharma 512
Alkylating Agents Pharma 4694
Antibodies Pharma 6045

(13) Additional Compounds for CD28 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD28: view

Transcripts for CD28 Gene

Unigene Clusters for CD28 Gene

CD28 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD28 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CD28 Gene

GeneLoc Exon Structure for
CD28
ECgene alternative splicing isoforms for
CD28

Expression for CD28 Gene

mRNA expression in normal human tissues for CD28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD28 Gene

This gene is overexpressed in Whole Blood (x11.4).

Protein differential expression in normal tissues from HIPED for CD28 Gene

This gene is overexpressed in CD8 Tcells (48.9) and CD4 Tcells (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD28 Gene



Protein tissue co-expression partners for CD28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD28 Gene:

CD28

SOURCE GeneReport for Unigene cluster for CD28 Gene:

Hs.443123

mRNA Expression by UniProt/SwissProt for CD28 Gene:

P10747-CD28_HUMAN
Tissue specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
genes like me logo Genes that share expression patterns with CD28: view

Primer Products

Orthologs for CD28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD28 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia CD28 34 35
  • 84.55 (n)
cow
(Bos Taurus)
Mammalia CD28 34 35
  • 81.43 (n)
rat
(Rattus norvegicus)
Mammalia Cd28 34
  • 77.67 (n)
mouse
(Mus musculus)
Mammalia Cd28 34 16 35
  • 77.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD28 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD28 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD28 34 35
  • 62.32 (n)
lizard
(Anolis carolinensis)
Reptilia CD28 35
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd28 34
  • 49.78 (n)
Species where no ortholog for CD28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD28 Gene

ENSEMBL:
Gene Tree for CD28 (if available)
TreeFam:
Gene Tree for CD28 (if available)

Paralogs for CD28 Gene

Paralogs for CD28 Gene

genes like me logo Genes that share paralogs with CD28: view

Variants for CD28 Gene

Sequence variations from dbSNP and Humsavar for CD28 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10179819 -- 203,716,949(+) cctca(C/G)cctcc intron-variant
rs10182554 -- 203,728,090(+) CAGGC(A/G)TAAGC intron-variant
rs10188188 -- 203,714,676(+) TGCTT(C/T)TGAAG intron-variant
rs10188756 -- 203,726,534(+) TTTGC(C/T)GGAGA intron-variant
rs10196383 -- 203,721,868(+) TGTCA(C/T)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD28 Gene

Variant ID Type Subtype PubMed ID
nsv1001799 CNV gain 25217958

Variation tolerance for CD28 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD28 Gene

Disorders for CD28 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CD28 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
mycosis fungoides
  • mf
rheumatoid arthritis
  • rheumatoid arthritis, progression of
common variable immunodeficiency
  • acquired agammaglobulinemia
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards
Search CD28 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD28

Genetic Association Database (GAD)
CD28
Human Genome Epidemiology (HuGE) Navigator
CD28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD28
genes like me logo Genes that share disorders with CD28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD28 Gene

Publications for CD28 Gene

  1. A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. (PMID: 11877290) Hanawa H. … Ochi A. (Blood 2002) 3 4 22 64
  2. Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer. (PMID: 19959217) Ivansson E.L. … Gyllensten U.B. (Gynecol. Oncol. 2010) 3 46 64
  3. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PMID: 20113255) Kim Y.O. … Hong S.J. (Clin. Chem. Lab. Med. 2010) 3 46 64
  4. CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. (PMID: 20126467) Gilani S.R. … Duncan S.R. (PLoS ONE 2010) 3 22 64
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64

Products for CD28 Gene

Sources for CD28 Gene

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