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Aliases for CD276 Gene

Aliases for CD276 Gene

  • CD276 Molecule 2 3 5
  • Costimulatory Molecule 3 4
  • CD276 Antigen 2 4
  • B7 Homolog 3 3 4
  • 4Ig-B7-H3 3 4
  • B7-H3 3 4
  • B7H3 3 4
  • B7RP-2 3

External Ids for CD276 Gene

Previous GeneCards Identifiers for CD276 Gene

  • GC15P071764
  • GC15P073976
  • GC15P050807

Summaries for CD276 Gene

Entrez Gene Summary for CD276 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for CD276 Gene

CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include neuroblastoma and autoimmune disease of central nervous system. Among its related pathways are Cell adhesion molecules (CAMs) and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include receptor binding. An important paralog of this gene is VTCN1.

UniProtKB/Swiss-Prot for CD276 Gene

  • May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Gene Wiki entry for CD276 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD276 Gene

Genomics for CD276 Gene

Regulatory Elements for CD276 Gene

Promoters for CD276 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD276 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD276 Gene

Chromosome:
15
Start:
73,683,966 bp from pter
End:
73,714,518 bp from pter
Size:
30,553 bases
Orientation:
Plus strand

Genomic View for CD276 Gene

Genes around CD276 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD276 Gene

Proteins for CD276 Gene

  • Protein details for CD276 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5ZPR3-CD276_HUMAN
    Recommended name:
    CD276 antigen
    Protein Accession:
    Q5ZPR3
    Secondary Accessions:
    • Q6P5Y4
    • Q6UXI2
    • Q8NBI8
    • Q8NC34
    • Q8NCB6
    • Q9BXR1

    Protein attributes for CD276 Gene

    Size:
    534 amino acids
    Molecular mass:
    57235 Da
    Quaternary structure:
    • Interacts with TREML2 and this interaction enhances T-cell activation.
    Miscellaneous:
    • B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.
    SequenceCaution:
    • Sequence=BAC11344.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CD276 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD276 Gene

Proteomics data for CD276 Gene at MOPED

Post-translational modifications for CD276 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD276 (CD276)

No data available for DME Specific Peptides for CD276 Gene

Domains & Families for CD276 Gene

Suggested Antigen Peptide Sequences for CD276 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5ZPR3

UniProtKB/Swiss-Prot:

CD276_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with CD276: view

Function for CD276 Gene

Molecular function for CD276 Gene

UniProtKB/Swiss-Prot Function:
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.
genes like me logo Genes that share phenotypes with CD276: view

Animal Models for CD276 Gene

MGI Knock Outs for CD276:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD276

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD276 Gene

Localization for CD276 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD276 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD276 Gene COMPARTMENTS Subcellular localization image for CD276 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane NAS 15188059
genes like me logo Genes that share ontologies with CD276: view

Pathways & Interactions for CD276 Gene

genes like me logo Genes that share pathways with CD276: view

Pathways by source for CD276 Gene

1 KEGG pathway for CD276 Gene
1 R&D Systems pathway for CD276 Gene

Interacting Proteins for CD276 Gene

Gene Ontology (GO) - Biological Process for CD276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 11224528
GO:0042110 T cell activation IDA 18650384
GO:0042130 negative regulation of T cell proliferation IEA --
GO:0045077 negative regulation of interferon-gamma biosynthetic process IEA --
GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA 11224528
genes like me logo Genes that share ontologies with CD276: view

No data available for SIGNOR curated interactions for CD276 Gene

Drugs & Compounds for CD276 Gene

(1) Drugs for CD276 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MGA271 Pharma antigen, inhibitor immunological response against cancer antigen 0
genes like me logo Genes that share compounds with CD276: view

Transcripts for CD276 Gene

Unigene Clusters for CD276 Gene

CD276 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD276 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CD276 Gene

GeneLoc Exon Structure for
CD276
ECgene alternative splicing isoforms for
CD276

Expression for CD276 Gene

mRNA expression in normal human tissues for CD276 Gene

Protein differential expression in normal tissues from HIPED for CD276 Gene

This gene is overexpressed in Nasal epithelium (25.1), Amniocyte (17.3), and Cerebral cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CD276 Gene



SOURCE GeneReport for Unigene cluster for CD276 Gene Hs.744915

mRNA Expression by UniProt/SwissProt for CD276 Gene

Q5ZPR3-CD276_HUMAN
Tissue specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
genes like me logo Genes that share expression patterns with CD276: view

Protein tissue co-expression partners for CD276 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CD276 Gene

Orthologs for CD276 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD276 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD276 35
  • 89.65 (n)
  • 93.37 (a)
CD276 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD276 35
  • 90.49 (n)
  • 93.62 (a)
CD276 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd276 35
  • 88.89 (n)
  • 92.78 (a)
Cd276 16
Cd276 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD276 35
  • 99 (n)
  • 98.88 (a)
CD276 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd276 35
  • 89.35 (n)
  • 93.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CD276 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD276 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD276 35
  • 73.36 (n)
  • 68.51 (a)
CD276 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD276 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd276 35
  • 57.73 (n)
  • 51.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15387 35
zebrafish
(Danio rerio)
Actinopterygii cd276 35
  • 61.65 (n)
  • 55.26 (a)
cd276 36
  • 52 (a)
OneToOne
Species with no ortholog for CD276:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD276 Gene

ENSEMBL:
Gene Tree for CD276 (if available)
TreeFam:
Gene Tree for CD276 (if available)

Paralogs for CD276 Gene

Paralogs for CD276 Gene

genes like me logo Genes that share paralogs with CD276: view

Variants for CD276 Gene

Sequence variations from dbSNP and Humsavar for CD276 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7173448 -, - 73,702,465(+) CTTCC(C/T)GGACC reference, missense
rs7173476 -, - 73,702,506(+) TGCAG(A/C/T)GCGTG reference, missense
rs11574477 - 73,702,585(+) CCTGC(A/T)GGTGG reference, missense
rs11574479 -, - 73,702,832(+) GGACA(C/T)GGTGA intron-variant, reference, missense
rs11574483 - 73,703,725(+) CCTGC(A/G)CTGCT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD276 Gene

Variant ID Type Subtype PubMed ID
esv272499 CNV Insertion 20981092
esv268888 CNV Insertion 20981092
nsv819417 CNV Gain 19587683
nsv471252 CNV Loss 18288195

Variation tolerance for CD276 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.61; 98.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD276 Gene

HapMap Linkage Disequilibrium report
CD276

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD276 Gene

Disorders for CD276 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD276 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD276 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD276

Genetic Association Database (GAD)
CD276
Human Genome Epidemiology (HuGE) Navigator
CD276
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD276
genes like me logo Genes that share disorders with CD276: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD276 Gene

Publications for CD276 Gene

  1. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. (PMID: 11224528) Chapoval A.I. … Chen L. (Nat. Immunol. 2001) 2 3 4 23 67
  2. The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. (PMID: 18690846) Chen Y.W. … Fodstad O. (Curr Cancer Drug Targets 2008) 3 23
  3. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. (PMID: 14764704) Steinberger P. … Knapp W. (J. Immunol. 2004) 3 23
  4. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. (PMID: 12906861) Ling V. … Collins M. (Genomics 2003) 3 23
  5. Characterization of mouse and human B7-H3 genes. (PMID: 12055244) Sun M. … Dong C. (J. Immunol. 2002) 2 3

Products for CD276 Gene

Sources for CD276 Gene

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