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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD276 Gene

protein-coding   GIFtS: 62
GCID: GC15P073976

CD276 Molecule

(Previous name: CD276 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD276 Molecule1 2     4Ig-B7-H32 3
CD276 Antigen1 2 3     B7-H32 3
B7H32 3 5     B7 Homolog 32 3
Costimulatory Molecule2 3     B7RP-22

External Ids:    HGNC: 191371   Entrez Gene: 803812   Ensembl: ENSG000001038557   OMIM: 6057155   UniProtKB: Q5ZPR33   

Export aliases for CD276 gene to outside databases

Previous GC identifers: GC15P071764 GC15P050807


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD276 Gene:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the
regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is
ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor
tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29
microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting
regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for CD276 Gene: 
CD276 (CD276 molecule) is a protein-coding gene. Diseases associated with CD276 include hypersensitivity reaction type ii disease, and clear cell renal cell carcinoma. GO annotations related to this gene include protein binding and receptor binding. An important paralog of this gene is ICOSLG.

UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
Function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in
tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of
neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the
regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and
fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be
redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of
cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor
signaling

Gene Wiki entry for CD276 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD276 gene promoter:
         HFH-3   C/EBPbeta   AML1a   HSF1 (long)   NF-E2 p45   FOXI1   HSF1short   NF-E2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD276 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD276

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD276


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q23-q24

CD276 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD276 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P073976:  view genomic region     (about GC identifiers)

Start:
73,976,307 bp from pter      End:
74,006,859 bp from pter
Size:
30,553 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3 (See protein sequence)
Recommended Name: CD276 antigen precursor  
Size: 534 amino acids; 57235 Da
Subunit: Interacts with TREML2 and this interaction enhances T-cell activation
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Miscellaneous: B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C
domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In
contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding
to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be
very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey
species
Sequence caution: Sequence=BAC11344.1; Type=Erroneous initiation;
Secondary accessions: Q6P5Y4 Q6UXI2 Q8NBI8 Q8NC34 Q8NCB6 Q9BXR1
Alternative splicing: 4 isoforms:  Q5ZPR3-1   Q5ZPR3-2   Q5ZPR3-3   Q5ZPR3-4   (Contains tandemly repeated immunoglobulin-like V and C domains)

Explore the universe of human proteins at neXtProt for CD276: NX_Q5ZPR3

Explore proteomics data for CD276 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5ZPR3

  • CD276 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD276 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001019907.1  NP_079516.1  

    ENSEMBL proteins: 
     ENSP00000455366   ENSP00000320084   ENSP00000441087   ENSP00000453907   ENSP00000452649  
     ENSP00000452736   ENSP00000454258   ENSP00000453330   ENSP00000452905   ENSP00000453336  
     ENSP00000456657   ENSP00000452669   ENSP00000454940   ENSP00000453014   ENSP00000453842  
     ENSP00000320058  

    Human Recombinant Protein Products for CD276: 
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    OriGene Purified Protein for CD276
    OriGene Protein Over-expression Lysate for CD276
    OriGene MassSpec for CD276 
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    Novus Biologicals CD276 Lysate
    Sino Biological Recombinant Protein for CD276
    Sino Biological Cell Lysate for CD276 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD276 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane NAS15188059
    GO:0016021integral to membrane NAS15188059

    CD276 for ontologies           About GeneDecksing



    CD276 Antibody Products: 
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    ThermoFisher Antibody for CD276
    LSBio Antibodies in human, mouse, rat for CD276 

    Assay Products for CD276: 
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    Cloud-Clone Corp. ELISAs for CD276 
    Cloud-Clone Corp. CLIAs for CD276


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5ZPR3

    ProtoNet protein and cluster: Q5ZPR3

    3 Blocks protein domains:
    IPB003597 Immunoglobulin C-type
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    CD276 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD276_HUMAN, Q5ZPR3
    Function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in
    tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of
    neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the
    regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and
    fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be
    redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of
    cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor
    signaling
    Induction: By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes.
    Up-regulated in cells mediating rejection of human transplants

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding NAS11224528
    GO:0005515protein binding IPI18650384
         
    CD276 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD276:
     Wnt reporter downregulated 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd276):
     cellular  hematopoietic system  immune system 

    CD276 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD276: Cd276tm1Mak Cd276tm1Wwh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD276 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD276

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD276 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD276 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD276:
    hsa-mir-29a (MIRT003343)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD276
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CD276 (see all 31):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-miR-539 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD276 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD276
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD276

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD276

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD276 (see all 11)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD276 (NM_025240)
    Sino Biological Human cDNA Clone for CD276
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD276
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD276
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                         Customized lentivirus expression plasmids for stable overexpression of CD276 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD276


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD276 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for CD276):
        Cell adhesion molecules (CAMs)


    CD276 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD276

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD276 (Q5ZPR33 ENSP000003200844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS11224528
    GO:0008283cell proliferation NAS11224528
    GO:0030501positive regulation of bone mineralization IEA--
    GO:0042102positive regulation of T cell proliferation IDA11224528
    GO:0042110T cell activation IDA18650384

    CD276 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD276

    Search CenterWatch for drugs/clinical trials and news about CD276

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD276 gene (2 alternative transcripts): 
    NM_001024736.1  NM_025240.2  

    Unigene Cluster for CD276:

    CD276 molecule
    Hs.744915  [show with all ESTs]
    Unigene Representative Sequence: NM_001024736
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000567189 ENST00000318443(uc002avv.1 uc002avw.1 uc010ulb.1)
    ENST00000537340(uc010bjd.1) ENST00000558689 ENST00000560786 ENST00000561213(uc002avu.1)
    ENST00000563584 ENST00000560928 ENST00000561416 ENST00000560995 ENST00000567582
    ENST00000561260 ENST00000564751 ENST00000561176 ENST00000557951 ENST00000559073
    ENST00000559978 ENST00000559465
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD276
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CD276 (see all 31):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-miR-539 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD276 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD276
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD276
    Clone
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    OriGene clones in human, mouse for CD276 (see all 11)
    OriGene ORF clones in mouse, rat for CD276
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD276 (NM_025240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD276
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD276
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    OriGene qPCR primer pairs and template standards for CD276
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD276
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD276

    Additional mRNA sequence: 

    AF302102.1 AJ583695.1 AJ583696.1 AK074997.1 AK075549.1 AK291721.1 AK292711.1 AK296358.1 
    AK298522.1 AK309728.1 AL360136.1 AY358343.1 BC011578.2 BC062581.1 

    17 DOTS entries:

    DT.446253  DT.100790303  DT.100790295  DT.100790298  DT.100790305  DT.100790304  DT.121051954  DT.121051957 
    DT.101984391  DT.100829484  DT.121051925  DT.100677239  DT.121051969  DT.40302712  DT.95158793  DT.206900 
    DT.97847603 

    24/294 AceView cDNA sequences (see all 294):

    AI609081 BX505928 BX337200 BU857362 BQ773007 BM719716 BX344771 BM695405 
    AI273022 BM854768 AF302102 AI419725 AI587194 AW338382 CB142026 BU944106 
    AW088044 BM006807 AA130156 BM705706 BP364239 BM671628 AK074997 CA488605 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD276    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for CD276

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD276 expression in normal human tissues (normalized intensities)      CD276 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTATTCT
    CD276 Expression
    About this image


    CD276 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
             endometrial endothelial cell   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             oral mucosa ; squamous epithelial cells   
             mouth   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CD276 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD276

    SOURCE GeneReport for Unigene cluster: Hs.744915

    UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
    Tissue specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly
    expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial
    cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester
    placenta and term placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD276: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD276
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD276

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD276 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2761 , 5 CD276 antigen1, 5 88.89(n)1
    92.78(a)1
      9 (31.79 cM)5
    1026571  NM_133983.41  NP_598744.11 
     585243005 
    chicken
    (Gallus gallus)
    Aves CD2761 CD276 molecule 73.36(n)
    68.51(a)
      415315  XM_413702.3  XP_413702.2 
    lizard
    (Anolis carolinensis)
    Reptilia CD2766
    CD276 molecule
    62(a)
    1 ↔ 1
    GL343517.1(369428-394325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153872 Xenopus laevis transcribed sequence with weak similarity more 68.63(n)    CB207657.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd2761 CD276 molecule 61.99(n)
    55.68(a)
      791140  NM_001080622.1  NP_001074091.1 


    ENSEMBL Gene Tree for CD276 (if available)
    TreeFam Gene Tree for CD276 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD276 gene
    ICOSLG2  VTCN12  HHLA22  
    6 SIMAP similar genes for CD276 using alignment to 10 protein entries:     CD276_HUMAN (see all proteins):
    BTN3A1    MOG    BTN3A2    BTN3A3    HHLA2    CD274

    CD276 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/729 SNPs in CD276 are shown (see all 729)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869477881,2
    --73974651(+) CATTTC/TCTTCC 2 -- us2k10--------
    rs1395116861,2
    --73974729(+) GTGATA/GTTCCT 2 -- us2k10--------
    rs1914650001,2
    --73974737(+) CCTTCA/GCTGTC 2 -- us2k10--------
    rs785528691,2
    F--73974780(+) CCTTAG/AGACAG 2 -- us2k11Minor allele frequency- A:0.50NA 4
    rs745983321,2
    F--73974792(+) ACCAGC/TGTCAC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1836020971,2
    --73974847(+) GGAAAA/GTAAGT 2 -- us2k10--------
    rs1496783941,2
    --73974890(+) TCCTGC/TAGCAG 2 -- us2k10--------
    rs1162997421,2
    F--73974909(+) GCTCCC/TTCAGC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1454623131,2
    --73975001(+) CAGACC/TCAGGC 2 -- us2k10--------
    rs1149642581,2
    C,F--73975049(+) AGCAGC/TGTGGA 2 -- us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for CD276 (73976307 - 74006859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD276:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272499CNV Insertion20981092
    esv268888CNV Insertion20981092
    nsv471252CNV Loss18288195
    nsv819417CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605715    OMIM disorders: --

    17 diseases for CD276:    About MalaCards
    hypersensitivity reaction type ii disease    clear cell renal cell carcinoma    myasthenia gravis    vaccinia
    renal cell carcinoma    bipolar disorder    multiple sclerosis    neuroblastoma
    pancreatic cancer    gastric cancer    lung cancer    pancreatitis
    prostate cancer    ovarian cancer    prostatitis    hepatocellular carcinoma
    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for CD276:
    Hypersensitivity reaction type II disease     Vaccinia     Multiple sclerosis

    CD276 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD276
    Human Genome Epidemiology (HuGE) Navigator: CD276 (1 document)

    Export disorders for CD276 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD276 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with CD276)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. (PubMed id 11224528)1, 2, 3, 9 Chapoval A.I.... Chen L. (2001)
    2. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. (PubMed id 12906861)1, 2, 9 Ling V.... Collins M. (2003)
    3. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. (PubMed id 14764704)1, 2, 9 Steinberger P....Knapp W. (2004)
    4. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)1, 4 Smith E.N....Kelsoe J.R. (2011)
    6. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT- 2) is a counter-receptor for B7-H3 and enhances T cell responses. (PubMed id 18650384)1, 2 Hashiguchi M....Azuma M. (2008)
    7. B7-H3: another molecule marker for Mo-DCs? (PubMed id 16274630)1, 2 Zhang G.B.... Zhang X.G. (2005)
    8. Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells. (PubMed id 15961727)1, 2 Kim J.... Schleimer R.P. (2005)
    9. B7-H3 promotes acute and chronic allograft rejection. (PubMed id 15682454)1, 2 Wang L.... Hancock W.W. (2005)
    10. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80381 HGNC: 19137 AceView: B7H3 Ensembl:ENSG00000103855 euGenes: HUgn80381
    ECgene: CD276 Kegg: 80381 H-InvDB: CD276

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD276 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD276 gene:
    Search GeneIP for patents involving CD276

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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