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CD276 Gene

protein-coding   GIFtS: 59
GCID: GC15P073976

CD276 Molecule

(Previous name: CD276 antigen)
  Search for CD276
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD276 Molecule1 2     4Ig-B7-H32 3
CD276 Antigen1 2 3     B7-H32 3
B7H32 3 5     B7 Homolog 32 3
Costimulatory Molecule2 3     B7RP-22

External Ids:    HGNC: 191371   Entrez Gene: 803812   Ensembl: ENSG000001038557   OMIM: 6057155   UniProtKB: Q5ZPR33   

Export aliases for CD276 gene to outside databases

Previous GC identifers: GC15P071764 GC15P050807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD276 Gene:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the
regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is
ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor
tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29
microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting
regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for CD276 Gene:
CD276 (CD276 molecule) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is VTCN1.

UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
Function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in
tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of
neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the
regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and
fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be
redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of
cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor
signaling

Gene Wiki entry for CD276 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CD276 gene promoter:
         HFH-3   C/EBPbeta   AML1a   HSF1 (long)   NF-E2 p45   FOXI1   HSF1short   NF-E2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD276 promoter sequence
   Search Chromatin IP Primers for CD276

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD276


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q23-q24

CD276 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD276 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P073976:  view genomic region     (about GC identifiers)

Start:
73,976,307 bp from pter      End:
74,006,859 bp from pter
Size:
30,553 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3 (See protein sequence)
Recommended Name: CD276 antigen precursor  
Size: 534 amino acids; 57235 Da
Subunit: Interacts with TREML2 and this interaction enhances T-cell activation
Miscellaneous: B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C
domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In
contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding
to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be
very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey
species
Sequence caution: Sequence=BAC11344.1; Type=Erroneous initiation;
Secondary accessions: Q6P5Y4 Q6UXI2 Q8NBI8 Q8NC34 Q8NCB6 Q9BXR1
Alternative splicing: 4 isoforms:  Q5ZPR3-1   Q5ZPR3-2   Q5ZPR3-3   Q5ZPR3-4   (Contains tandemly repeated immunoglobulin-like V and C domains)

Explore the universe of human proteins at neXtProt for CD276: NX_Q5ZPR3

Explore proteomics data for CD276 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn91, Asn104, Asn189, Asn215, Asn322, Asn407, Asn433
  • Modification sites at PhosphoSitePlus

  • See CD276 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019907.1  NP_079516.1  

    ENSEMBL proteins: 
     ENSP00000455366   ENSP00000320084   ENSP00000441087   ENSP00000453907   ENSP00000452649  
     ENSP00000452736   ENSP00000454258   ENSP00000453330   ENSP00000452905   ENSP00000453336  
     ENSP00000456657   ENSP00000452669   ENSP00000454940   ENSP00000453014   ENSP00000453842  
     ENSP00000320058  

    CD276 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD276
    OriGene Protein Over-expression Lysate for CD276
    OriGene MassSpec for CD276
    OriGene Custom Protein Services for CD276
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    Novus Biologicals CD276 Lysate
    Sino Biological Recombinant Protein for CD276
    Sino Biological Cell Lysate for CD276
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD276

     
    Search eBioscience for Proteins for CD276 

    CD276 Antibody Products:

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    Abcam antibodies for CD276
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    ThermoFisher Antibody for CD276
    LSBio Antibodies in human, mouse, rat for CD276

    CD276 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CD276 (B7-H3)
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    Cloud-Clone Corp. ELISAs for CD276
    Cloud-Clone Corp. CLIAs for CD276
    Search eBioscience for ELISAs for CD276 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5ZPR3

    ProtoNet protein and cluster: Q5ZPR3

    3 Blocks protein domains:
    IPB003597 Immunoglobulin C-type
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with CD276           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD276_HUMAN, Q5ZPR3
    Function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in
    tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of
    neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the
    regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and
    fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be
    redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of
    cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor
    signaling
    Induction: By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes.
    Up-regulated in cells mediating rejection of human transplants

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding NAS11224528
    GO:0005515protein binding IPI18650384
         
    Find genes that share ontologies with CD276           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD276:
     Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd276):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD276           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD276: Cd276tm1Mak Cd276tm1Wwh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD276
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD276

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD276
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD276

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD276:
    hsa-mir-1301-3p (MIRT036011), hsa-let-7a-5p (MIRT052388), hsa-mir-92a-3p (MIRT049416), hsa-mir-335-5p (MIRT018004), hsa-mir-29a-3p (MIRT003343), hsa-mir-1260b (MIRT052669), hsa-mir-421 (MIRT039444), hsa-mir-28-5p (MIRT050009)

    Block miRNA regulation of human, mouse, rat CD276 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD276 (see all 31):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-miR-539 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD276 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD276
    Predesigned siRNA for gene silencing in human, mouse, rat CD276

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD276

    Clone
    Products:
         
    OriGene clones in human, mouse for CD276 (see all 11)
    OriGene ORF clones in mouse, rat for CD276
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD276 (NM_025240)
    Sino Biological Human cDNA Clone for CD276
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD276
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD276

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD276
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD276 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD276


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD276_HUMAN, Q5ZPR3: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane NAS15188059
    GO:0016021integral component of membrane NAS15188059

    Find genes that share ontologies with CD276           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD276 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with CD276           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD276):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD276: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CD276

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD276 (Q5ZPR33 ENSP000003200844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS11224528
    GO:0008283cell proliferation NAS11224528
    GO:0030501positive regulation of bone mineralization IEA--
    GO:0042102positive regulation of T cell proliferation IDA11224528
    GO:0042110T cell activation IDA18650384

    Find genes that share ontologies with CD276           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD276



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD276 gene (2 alternative transcripts): 
    NM_001024736.1  NM_025240.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000567189 ENST00000318443(uc002avv.1 uc002avw.1 uc010ulb.1)
    ENST00000537340(uc010bjd.1) ENST00000558689 ENST00000560786 ENST00000561213(uc002avu.1)
    ENST00000563584 ENST00000560928 ENST00000561416 ENST00000560995 ENST00000567582
    ENST00000561260 ENST00000564751 ENST00000561176 ENST00000557951 ENST00000559073
    ENST00000559978 ENST00000559465
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD276 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD276 (see all 31):
    hsa-miR-3910 hsa-miR-520d-5p hsa-let-7d hsa-miR-539 hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD276 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD276
    Predesigned siRNA for gene silencing in human, mouse, rat CD276
    Clone
    Products:
         
    OriGene clones in human, mouse for CD276 (see all 11)
    OriGene ORF clones in mouse, rat for CD276
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD276 (NM_025240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD276
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD276
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD276
    OriGene qSTAR qPCR primer pairs in human, mouse for CD276
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD276
      QuantiTect SYBR Green Assays in human, mouse, rat CD276
      QuantiFast Probe-based Assays in human, mouse, rat CD276

    Selected AceView cDNA sequences (see all 294):

    BU944106 BQ278722 BM695405 AI587194 BM023226 BM768585 BC062581 BM719716 
    BM684081 BQ004955 AI419725 BE906866 CK904466 BM551702 BU956233 BX344771 
    BM007118 BG236830 BQ773007 CA488605 AW088044 BX337200 BX505928 AI683457 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD276    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for CD276

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD276 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTATTCT
    CD276 Expression
    About this image


    CD276 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)
             Rib
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CD276 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD276 Protein Expression

    UniProtKB/Swiss-Prot: CD276_HUMAN, Q5ZPR3
    Tissue specificity: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly
    expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial
    cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester
    placenta and term placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD276: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD276
    OriGene qSTAR qPCR primer pairs in human, mouse for CD276
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD276
    QuantiTect SYBR Green Assays in human, mouse, rat CD276
    QuantiFast Probe-based Assays in human, mouse, rat CD276
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD276

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD276 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2761 , 5 CD276 antigen1, 5 88.89(n)1
    92.78(a)1
      9 (31.79 cM)5
    1026571  NM_133983.41  NP_598744.11 
     585243005 
    chicken
    (Gallus gallus)
    Aves CD2761 CD276 molecule 73.36(n)
    68.51(a)
      415315  XM_413702.4  XP_413702.2 
    lizard
    (Anolis carolinensis)
    Reptilia CD2766
    CD276 molecule
    64(a)
    1 ↔ 1
    GL343517.1(369428-394325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153872 Xenopus laevis transcribed sequence with weak similarity more 68.63(n)    CB207657.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd2761 CD276 molecule 61.65(n)
    55.26(a)
      791140  NM_001080622.1  NP_001074091.1 


    ENSEMBL Gene Tree for CD276 (if available)
    TreeFam Gene Tree for CD276 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CD276 gene
    VTCN12  HHLA22  
    6 SIMAP similar genes for CD276 using alignment to 10 protein entries:     CD276_HUMAN (see all proteins):
    BTN3A1    MOG    BTN3A2    BTN3A3    HHLA2    CD274

    Find genes that share paralogs with CD276           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CD276 (see all 729)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869477881,2
    --73974651(+) CATTTC/TCTTCC 2 -- us2k10--------
    rs1395116861,2
    --73974729(+) GTGATA/GTTCCT 2 -- us2k10--------
    rs1914650001,2
    --73974737(+) CCTTCA/GCTGTC 2 -- us2k10--------
    rs785528691,2
    F--73974780(+) CCTTAG/AGACAG 2 -- us2k11Minor allele frequency- A:0.50NA 4
    rs745983321,2
    F--73974792(+) ACCAGC/TGTCAC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1836020971,2
    --73974847(+) GGAAAA/GTAAGT 2 -- us2k10--------
    rs1496783941,2
    --73974890(+) TCCTGC/TAGCAG 2 -- us2k10--------
    rs1162997421,2
    F--73974909(+) GCTCCC/TTCAGC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1454623131,2
    --73975001(+) CAGACC/TCAGGC 2 -- us2k10--------
    rs1149642581,2
    C,F--73975049(+) AGCAGC/TGTGGA 2 -- us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for CD276 (73976307 - 74006859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD276:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272499CNV Insertion20981092
    esv268888CNV Insertion20981092
    nsv471252CNV Loss18288195
    nsv819417CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD276
    DNA2.0 Custom Variant and Variant Library Synthesis for CD276

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605715    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for CD276:
    Hypersensitivity reaction type II disease     Vaccinia     Multiple sclerosis

    Find genes that share disorders with CD276           About GenesLikeMe

    Genetic Association Database (GAD): CD276
    Human Genome Epidemiology (HuGE) Navigator: CD276 (1 document)

    Export disorders for CD276 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD276 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with CD276)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. (PubMed id 11224528)1, 2, 3, 9 Chapoval A.I.... Chen L. (Nat. Immunol. 2001)
    2. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. (PubMed id 12906861)1, 2, 9 Ling V.... Collins M. (Genomics 2003)
    3. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. (PubMed id 14764704)1, 2, 9 Steinberger P....Knapp W. (J. Immunol. 2004)
    4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    5. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. (PubMed id 21738484)1, 4 Smith E.N....Kelsoe J.R. (PLoS Genet. 2011)
    6. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT- 2) is a counter-receptor for B7-H3 and enhances T cell responses. (PubMed id 18650384)1, 2 Hashiguchi M....Azuma M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells. (PubMed id 15961727)1, 2 Kim J.... Schleimer R.P. (Am. J. Respir. Cell Mol. Biol. 2005)
    8. The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta. (PubMed id 16049332)1, 2 Petroff M.G.... Holets L. (Am. J. Pathol. 2005)
    9. B7-H3: another molecule marker for Mo-DCs? (PubMed id 16274630)1, 2 Zhang G.B.... Zhang X.G. (Cell. Mol. Immunol. 2005)
    10. B7-H3 promotes acute and chronic allograft rejection. (PubMed id 15682454)1, 2 Wang L.... Hancock W.W. (Eur. J. Immunol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80381 HGNC: 19137 AceView: B7H3 Ensembl:ENSG00000103855 euGenes: HUgn80381
    ECgene: CD276 Kegg: 80381 H-InvDB: CD276

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD276 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD276 gene:
    Search GeneIP for patents involving CD276

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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