CD274 Gene

Aliases
for CD274 gene

Summaries
for CD274 gene

Genomic Views
for CD274 gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008413.18  

SwitchGear Promoter luciferase reporter plasmid: CD274 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD274

CD274 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005444:  view genomic region     (about GC identifiers)

Proteins
for CD274 gene

4 PDB 3D structures from and Proteopedia for CD274:

3BIK (3D)        3BIS (3D)        3FN3 (3D)        3SBW (3D)    

Explore the universe of human proteins at neXtProt for CD274: NX_Q9NZQ7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD274 (B7-H1/PD-L1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CD274 OriGene Custom Protein Services for CD274
	GenScript Custom Purified and Recombinant Proteins Services for CD274
	Novus Biologicals CD274 Proteins Novus Biologicals CD274 Lysate
	Sino Biological Recombinant Protein for CD274
	ProSpec Recombinant Protein for CD274
	Uscn Proteins for CD274

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD274 (B7-H1/PD-L1)
	OriGene Antibodies (see all 2): CD274 OriGene Custom Antibody Services for CD274
	GenScript Custom Superior Antibodies Services for CD274
	Novus Biologicals CD274 Antibodies
	Search for Antibodies for CD274 at Abcam
	Uscn Antibodies for CD274
	ThermoFisher Antibodies for CD274

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD274
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD274

Protein Domains /
Families
for CD274 gene

ProtoNet protein and cluster: Q9NZQ7

Function
for CD274 gene

miRNA Products:		miRTarBase miRNAs that target CD274: hsa-mir-513a-5p (MIRT003923)
		OriGene 3'-UTR Clone: CD274 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD274
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CD274 (see all 36):
		hsa-miR-21* hsa-miR-142-5p hsa-miR-548j hsa-miR-106a hsa-miR-93 hsa-miR-155 hsa-miR-548a-5p hsa-miR-548d-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CD274 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD274 (see all 4) OriGene shRNA RFP: CD274 OriGene siRNA: CD274
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD274

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD274

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD274 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD274 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD274 (NM_014143)
		Sino Biological Human cDNA Clone for CD274
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD274
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD274

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD274
		Search LifeMap BioReagents cell lines for CD274

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD274

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 5 alleles) (MGI details for Cd274)

Pathways & Interactions
for CD274 gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Cell adhesion molecules (CAMs)	Cell adhesion molecules (CAMs) 1.00
3	Translocation of ZAP-70 to Immunological synapse	PD-1 signaling 0.76
4	CD28 co-stimulation	Costimulation by the CD28 family 0.41

4        Reactome Pathways for CD274

	Costimulation by the CD28 family
	PD-1 signaling
	Adaptive Immune System
	Immune System

1         Kegg Pathway  (Kegg details for CD274)

Cell adhesion molecules (CAMs)

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for CD274 gene

Transcripts
for CD274 gene

Expression
for CD274 gene

CD274 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTATTTGT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD274 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD274
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD274
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD274

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD274

Orthologs
for CD274 gene

Paralogs
for CD274 gene

Paralogs for CD274 gene

PDCD1LG2²  

3 SIMAP similar genes for CD274 using alignment to 2 protein entries:     PD1L1_HUMAN (see all proteins):

PDL2    PDCD1LG2    CD276

CD274 for paralogs           About GeneDecksing

Genomic Variants
for CD274 gene

10/416 NCBI SNPs in CD274 are shown (see all 416)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1504392311,2		--	5448539(+)	TAATAA/GAATTT	3	--	us2k1		0	--	--	--	--
rs1382616401,2		--	5448573(+)	TTTTCA/CATCTC	3	--	us2k1		0	--	--	--	--
rs1429834881,2		--	5448634(+)	AGGTGG/TGAAAG	3	--	us2k1		0	--	--	--	--
rs767414681,2	F,	--	5448641(+)	AAAGAT/CGAACA	3	--	us2k1		1		WA	118
rs8223361,2	C,F,A,H,	--	5448690(+)	GAGCAG/CCAAGC	3	--	us2k1		16		NS EA NA CSA WA	1146
rs1834006201,2		--	5448763(+)	TGATCA/GTTTAG	3	--	us2k1		0	--	--	--	--
rs1872528321,2		--	5448815(+)	CCCATA/CCCCAG	3	--	us2k1		0	--	--	--	--
rs1461439761,2		--	5448859(+)	CTAGGA/GGGATA	3	--	us2k1		0	--	--	--	--
rs1390237651,2		--	5448896(+)	TTATTG/TGCCCA	3	--	us2k1		0	--	--	--	--
rs736416151,2	C,F,	--	5448956(+)	TTTTGT/CTTTGT	3	--	us2k1		4		WA CSA NA	242

HapMap Linkage Disequilibrium report for CD274 (5450503 - 5470567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CD274
     4 CNVs: 52836 3756 52835 52834

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD274

DNA2.0 Custom Variant and Variant Library Synthesis for CD274

Disorders / Diseases
for CD274 gene

20/79 diseases for CD274

10/22 Novoseek disease relationships for CD274 gene (see all 22)    About this table

Publications
for CD274 gene

PubMed articles for CD274 gene, integrated from 9 sources (see all 287): (articles sorted by number of sources associating them with CD274)

Utopia: connect your pdf to the dynamic world of online information

1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PubMed id 11015443)^{1, 2, 3, 9} Freeman G.J.... Honjo T. (2000)
2. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PubMed id 10581077)^{1, 2, 3} Dong H.... Chen L. (1999)
3. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PubMed id 15780196)^{1, 2, 9} He X.-H.... Liu Y. (2005)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. (PubMed id 15342209)^{1, 9} Schreiner B....Wiendl H. (2004)
8. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. (PubMed id 17186290)^{1, 9} Nakanishi J....Ueda S. (2007)
9. Interaction of human PD-L1 and B7-1. (PubMed id 18585785)^{1, 9} Butte M.J....Sharpe A.H. (2008)
10. Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia. (PubMed id 18756622)^{1, 9} Chen X....Ma X. (2008)

External Searches for CD274 gene

Genome Databases showing CD274 gene

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Specialized Databases showing CD274 gene

Products
for CD274 gene