Aliases for CD274 Gene
External Ids for CD274 Gene
Previous Symbols for CD274 Gene
GeneCards Summary for CD274 Gene
CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include cheilitis and actinic cheilitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and CD28 co-stimulation. An important paralog of this gene is PDCD1LG2.
UniProtKB/Swiss-Prot for CD274 Gene
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.