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Aliases for CD274 Gene

Aliases for CD274 Gene

  • CD274 Molecule 2 3 5
  • CD274 Antigen 2 3 4
  • B7 Homolog 1 2 3 4
  • Programmed Cell Death 1 Ligand 1 2 3
  • PDCD1 Ligand 1 3 4
  • PDCD1LG1 3 4
  • PDCD1L1 3 4
  • PD-L1 3 4
  • B7H1 3 4
  • PDL1 3 4
  • Programmed Death Ligand 1 4
  • B7-H1 4
  • B7-H 3

External Ids for CD274 Gene

Previous HGNC Symbols for CD274 Gene

  • PDCD1LG1

Previous GeneCards Identifiers for CD274 Gene

  • GC09P005444

Summaries for CD274 Gene

Entrez Gene Summary for CD274 Gene

  • This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CIViC summary for CD274 Gene

  • CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.

GeneCards Summary for CD274 Gene

CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Primary Mediastinal Large B-Cell Lymphoma and Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis. Among its related pathways are Innate Immune System and CD28 co-stimulation. An important paralog of this gene is PDCD1LG2.

UniProtKB/Swiss-Prot for CD274 Gene

  • Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Gene Wiki entry for CD274 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD274 Gene

Genomics for CD274 Gene

Regulatory Elements for CD274 Gene

Enhancers for CD274 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G005448 2 FANTOM5 Ensembl ENCODE dbSUPER 63.7 +1.7 1744 8.0 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 CD274 PDCD1LG2 JAK2 RIC1 PLGRKT
GH09G005459 1.7 FANTOM5 Ensembl ENCODE dbSUPER 41 +9.4 9361 0.9 TBP TBL1XR1 BMI1 CBX5 FOS RELB ETV6 IKZF2 SMAD5 CEBPB CD274 PLGRKT PDCD1LG2 JAK2 RIC1
GH09G005569 1.2 FANTOM5 Ensembl ENCODE 49.4 +119.4 119420 0.8 ZNF316 ATF3 MAFG NFE2 EMSY MAFK CD274 PDCD1LG2 PLGRKT RIC1 GC09M005559 GC09P005527
GH09G005492 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31 +43.6 43556 1.9 HDGF PKNOX1 ATF1 YBX1 YY1 ZNF766 ZNF207 FOS CAVIN1 JUNB CD274 PDCD1LG2 JAK2 RIC1 PLGRKT
GH09G005508 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28 +61.7 61742 7.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 RFX5 GATA2 ZNF143 CD274 PDCD1LG2 PLGRKT GC09M005520
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD274 on UCSC Golden Path with GeneCards custom track

Promoters for CD274 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232827 319 1801 HDGF ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 SP3

Genomic Location for CD274 Gene

Chromosome:
9
Start:
5,450,381 bp from pter
End:
5,470,567 bp from pter
Size:
20,187 bases
Orientation:
Plus strand

Genomic View for CD274 Gene

Genes around CD274 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD274 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD274 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD274 Gene

Proteins for CD274 Gene

  • Protein details for CD274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ7-PD1L1_HUMAN
    Recommended name:
    Programmed cell death 1 ligand 1
    Protein Accession:
    Q9NZQ7
    Secondary Accessions:
    • B2RBA2
    • B4DU27
    • Q14CJ2
    • Q2V8D5
    • Q66RK1
    • Q6WEX4
    • Q9NUZ5

    Protein attributes for CD274 Gene

    Size:
    290 amino acids
    Molecular mass:
    33275 Da
    Quaternary structure:
    • Interacts with PDCD1.
    SequenceCaution:
    • Sequence=BAA91966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD274 Gene

    Alternative splice isoforms for CD274 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD274 Gene

Post-translational modifications for CD274 Gene

  • Glycosylation at posLast=3535, posLast=192192, posLast=200200, and posLast=219219
  • Modification sites at PhosphoSitePlus

Other Protein References for CD274 Gene

Assay Products

  • Abcam assays for CD274

No data available for DME Specific Peptides for CD274 Gene

Domains & Families for CD274 Gene

Protein Domains for CD274 Gene

Suggested Antigen Peptide Sequences for CD274 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZQ7

UniProtKB/Swiss-Prot:

PD1L1_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with CD274: view

Function for CD274 Gene

Molecular function for CD274 Gene

UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

Gene Ontology (GO) - Molecular Function for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD274: view
genes like me logo Genes that share phenotypes with CD274: view

Animal Models for CD274 Gene

MGI Knock Outs for CD274:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD274

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD274 Gene

Localization for CD274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD274 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD274 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD274: view

Pathways & Interactions for CD274 Gene

genes like me logo Genes that share pathways with CD274: view

Pathways by source for CD274 Gene

1 Cell Signaling Technology pathway for CD274 Gene

SIGNOR curated interactions for CD274 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 10581077
GO:0007165 signal transduction IDA 10581077
GO:0007166 cell surface receptor signaling pathway IDA 10581077
GO:0030335 positive regulation of cell migration IEA --
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD274: view

Drugs & Compounds for CD274 Gene

(11) Drugs for CD274 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atezolizumab Approved Pharma Target, antibody 0
Durvalumab Approved Pharma Target, binder 0
nivolumab Approved Pharma Therapeutic Antibodies, Immunotherapies 424
Pembrolizumab Approved Pharma 507
Avelumab Investigational Pharma Target, antagonist 0
genes like me logo Genes that share compounds with CD274: view

Transcripts for CD274 Gene

Unigene Clusters for CD274 Gene

CD274 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD274 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CD274 Gene

GeneLoc Exon Structure for
CD274
ECgene alternative splicing isoforms for
CD274

Expression for CD274 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD274 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD274 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD274 Gene



Protein tissue co-expression partners for CD274 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD274 Gene:

CD274

SOURCE GeneReport for Unigene cluster for CD274 Gene:

Hs.521989

mRNA Expression by UniProt/SwissProt for CD274 Gene:

Q9NZQ7-PD1L1_HUMAN
Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Evidence on tissue expression from TISSUES for CD274 Gene

  • Lung(4.6)
  • Liver(4.4)
  • Blood(3.4)
  • Spleen(3.3)
  • Lymph node(3.1)
  • Heart(2.3)
  • Intestine(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CD274: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD274 Gene

Orthologs for CD274 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD274 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD274 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia CD274 34 35
  • 83.97 (n)
cow
(Bos Taurus)
Mammalia CD274 34
  • 83.1 (n)
PD-L1 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd274 34
  • 76.59 (n)
mouse
(Mus musculus)
Mammalia Cd274 34 16 35
  • 76.36 (n)
oppossum
(Monodelphis domestica)
Mammalia CD274 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD274 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD274 34 35
  • 55.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd274 34
  • 49.49 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-241b2.5 34
  • 46.77 (n)
CD274 35
  • 15 (a)
OneToMany
Species where no ortholog for CD274 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD274 Gene

ENSEMBL:
Gene Tree for CD274 (if available)
TreeFam:
Gene Tree for CD274 (if available)

Paralogs for CD274 Gene

Paralogs for CD274 Gene

(3) SIMAP similar genes for CD274 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD274: view

Variants for CD274 Gene

Sequence variations from dbSNP and Humsavar for CD274 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000236972 -- 5,469,948(+) AATTC(C/T)GGCAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000430255 -- 5,451,976(+) ATGCA(A/G)GCCTC intron-variant, downstream-variant-500B
rs1000608610 -- 5,448,692(+) GCAGC(A/G)AGCTG upstream-variant-2KB
rs1000659170 -- 5,449,701(+) AGAGC(A/G)CCTAG upstream-variant-2KB
rs1000736188 -- 5,454,955(+) GTTAT(C/G)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD274 Gene

Variant ID Type Subtype PubMed ID
esv2759660 CNV loss 17122850
nsv466108 CNV gain 19166990
nsv509292 CNV insertion 20534489
nsv519771 CNV loss 19592680
nsv613196 CNV gain 21841781

Variation tolerance for CD274 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD274 Gene

Human Gene Mutation Database (HGMD)
CD274
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD274

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD274 Gene

Disorders for CD274 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CD274 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
htlv-1 associated myelopathy/tropical spastic paraparesis
  • tropical spastic paraparesis
lymphoepithelioma-like carcinoma
  • lymphoepithelial carcinoma
mediastinal malignant lymphoma
  • lymphoma of mediastinum
scrotum paget's disease
  • paget's disease of scrotum
- elite association - COSMIC cancer census association via MalaCards
Search CD274 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD274

Genetic Association Database (GAD)
CD274
Human Genome Epidemiology (HuGE) Navigator
CD274
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD274
genes like me logo Genes that share disorders with CD274: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD274 Gene

Publications for CD274 Gene

  1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PMID: 11015443) Freeman G.J. … Honjo T. (J. Exp. Med. 2000) 2 3 4 22 64
  2. Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (PMID: 19850680) Mitchell A.L. … Pearce S.H. (J. Clin. Endocrinol. Metab. 2009) 3 22 46 64
  3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PMID: 18322304) Hayashi M. … Komiya I. (Eur. J. Endocrinol. 2008) 3 22 46 64
  4. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PMID: 15780196) He X.-H. … Liu Y. (Acta Pharmacol. Sin. 2005) 3 4 22 64
  5. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PMID: 10581077) Dong H. … Chen L. (Nat. Med. 1999) 2 3 4 64

Products for CD274 Gene

Sources for CD274 Gene

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