Aliases for CD274 Gene
External Ids for CD274 Gene
Previous HGNC Symbols for CD274 Gene
Previous GeneCards Identifiers for CD274 Gene
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.
GeneCards Summary for CD274 Gene
CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Ovarian Carcinosarcoma and Primary Mediastinal Large B-Cell Lymphoma. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Translocation of ZAP-70 to Immunological synapse. An important paralog of this gene is PDCD1LG2.
UniProtKB/Swiss-Prot for CD274 Gene
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.