V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CD274 Gene

protein-coding GIFtS: 57

GC09P005444

CD274 molecule
(Previous names: programmed cell death 1 ligand 1, CD274 antigen )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PDCD1LG1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
B7-H ^¹, ²
B7-H1 ^³
B7H1 ^¹, ², ³
MGC142294 ^²
MGC142296 ^²
OTTHUMP00000021029 ^²
PD-L1 ^¹, ², ³
PDCD1L1 ^², ³
PDCD1LG1 ^², ³
PDL1 ^¹, ², ³

Descriptions
B7 homolog 1 ^³
CD274 antigen ^¹, ², ³
CD274 molecule ^²
PDCD1 ligand 1 ^³
Programmed death ligand 1 ^³
programmed cell death 1 ligand 1 ^¹, ²

External Ids
HGNC: 17635¹
Entrez Gene: 29126²
UniProtKB: Q9NZQ7³
Ensembl: ENSG00000120217⁷

Search outside databases for aliases for CD274 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7

Function: Involved in the costimulatory signal, essential for T-cell proliferation and production

of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1

inhibits T-cell proliferation and cytokine production

Gene Wiki entry for CD274

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD274 gene

Entrez Gene cytogenetic band: 9p24 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.1

CD274 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P005444: (about GC identifiers)

Start:	5,440,559 bp from pter
End:	5,471,569 bp from pter
Size:	31,011 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7 (See protein sequence)

Recommended Name: Programmed cell death 1 ligand 1 precursor

Size: 290 amino acids; 33275 Da

Subunit: Interacts with PDCD1

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Endomembrane system; Single-pass type I membrane protein

PDB structure from and Proteopedia :

3BIK (3D)

3BIS (3D)

Secondary accessions: B4DU27 Q14CJ2 Q66RK1 Q6WEX4 Q9NUZ5

Alternative splicing: 3 isoforms: Q9NZQ7-1 Q9NZQ7-2 Q9NZQ7-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_054862.1

ENSEMBL proteins:

ENSP00000370989 ENSP00000262354 ENSP00000370985

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CD274 (B7-H1/PD-L1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD274)
	Human Recombinant Proteins from Abnova (CD274)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0012505	endomembrane system	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for CD274:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CD274
	R&D Systems Antibodies for CD274 (B7-H1/PD-L1)
	Antibodies from Abcam (CD274), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD274)
	Novus Biologicals Antibodies for CD274

Assays for CD274:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NZQ7

ProtoNet protein and cluster: Q9NZQ7

1 Blocks protein family: IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7

Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD274)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD274)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014143

Applied Biosystems Silencer® siRNAs for CD274

Sigma-Aldrich siRNA for CD274

Sigma-Aldrich shRNA Panels and shRNA for CD274

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014143
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014143
untagged cDNA clone in CMV expression vector: NM_014143

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014143

UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7

Function: Involved in the costimulatory signal, essential for T-cell proliferation and production

of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1

inhibits T-cell proliferation and cytokine production

Induction: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS

and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking

3 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cd274):

hematopoietic system

immune system

no phenotypic analysis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CD274

5/17 Interacting proteins for CD274 (ENSP00000262354³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDCD1	ENSP00000335062³	STRING (score=.997)
ICOS	ENSP00000319476³	STRING (score=.964)
CD28	ENSP00000324890³	STRING (score=.96)
CTLA4	ENSP00000303939³	STRING (score=.959)
CD8A	ENSP00000283635³	STRING (score=.9)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	10581077
GO:0007166	cell surface receptor linked signal transduction	TAS	10581077
GO:0008283	cell proliferation	TAS	10581077

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD274
2 Novoseek chemical compound relationships for CD274 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin	15.72	1	15780196 (1)
nitric oxide	0.00	7	16606666 (1), 17161871 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD274)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD274)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014143

Sigma-Aldrich siRNA for CD274

Sigma-Aldrich shRNA Panels and shRNA for CD274

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014143

REFSEQ mRNAs for CD274 gene:

NM_014143.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014143

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014143
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014143
                                 untagged cDNA clone in CMV expression vector: NM_014143

Additional cDNA sequence:

AF177937.1 AF233516.1 AK001894.1 AK300470.1 AK314567.1 AY254342.1 AY291313.1 AY714881.1

BC069381.1 BC074984.2 BC113734.1 BC113736.1 DQ286582.1 DQ836393.1

8 DOTS entries:

DT.121168514 DT.95134823 DT.100831039 DT.101981824 DT.203629 DT.423576 DT.40281578 DT.91904332

24/92 AceView cDNA sequences (see all 92 ):

BQ012403 BU629434 AI678841 BU621474 BX399016 AF233516 CK904743 CA309674

BC074984 NM_014143 AY254342 AK001894 AY291313 BX351715 BQ013314 N32809

AF177937 AY714881 BE043008 BG542122 CF529178 AU134845 CF529106 BC069381

highest scoring ESTs for CD274:

AF177937 AF233516 AK001894 AU156706 AY254342 AY291313 BC069381 BQ012403 BQ013314 BQ013977

Unigene Cluster for CD274:

CD274 molecule

Hs.521989 [show with all ESTs]

Unigene Representative Sequence: NM_014143

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CD274

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8
SP1:
SP2:													-						-
SP3:									-
SP4:					-		-

About this scheme

ECgene alternative splicing isoforms for CD274

3 Ensembl transcripts including schematic representations:

ENST00000381577 ENST00000262354 ENST00000381573

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD274 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD274

¹ / ² / ³

3 probe-sets matching CD274 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56769_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AA292201	0.40	1.00	0.76	1
223834_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF233516	0.80	1.00	0.91	1
223834_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGTATTTGT

SOURCE GeneReport for Unigene cluster: Hs.521989
UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7
Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly
expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells,
dendritic cells, keratinocytes and monocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD274 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD274¹	--	CD274 molecule	86.11(n) 81.14(a)	484186 XM_541302.2 XP_541302.2
chimpanzee (Pan troglodytes)	CD274¹	--	CD274 molecule	99.54(n) 99.66(a)	464981 XM_001140705.1 XP_001140705.1
cow (Bos taurus)	CD274¹	--	CD274 molecule	83.27(n) 75.85(a)	533834 XM_613366.3 XP_613366.3
rat (Rattus norvegicus)	Cd274¹	--	CD274 molecule	76.24(n) 70.21(a)	499342 XM_574652.2 XP_574652.2
mouse (Mus musculus)	Cd274^{1, 5}	19⁵	CD274 antigen^{1, 5}	76.36(n)¹ 69.9(a)¹	60533¹ NM_021893.2¹ NP_068693.1¹ AF233517⁵ AF317088⁵ (see all 8)

About this table Species with no ortholog for CD274

ENSEMBL Gene Tree for CD274

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CD274 gene

PDCD1LG2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/125 NCBI SNPs in CD274 are shown (see all 125 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2297136^1,2	A,C,F,H,O	5457955(-)	`ACGGGT/CCCATT`	1	--	ut3¹ ese³		8		EA NA EU WA	1490
--	rs822337^1,2	A,C,F,H	5439154(+)	`GTACCA/TGTAAA`	1	--	ng5¹		4		EU EA WA	418
	rs4143815^1,2	A,C,F,H	5458257(+)	`AATTTC/GTTTTC`	1	--	ut3¹ ese³		12		EA NA EU WA	1054
	rs822336^1,2	A,F,H	5438690(+)	`GAGCAG/CCAAGC`	1	--	ng5¹		8		EU EA WA NA	778
	rs10815225^1,2	A,C	5440497(+)	`CCTCCC/GGGCCT`	1	--	ng5¹		0	--	--	--	--
	rs12551333^1,2	C,H	5447171(+)	`AATTAG/CACCTG`	1	H/D	mis¹ ese³		4		EU EA WA	416
	rs1329947^1,2	C	5439336(-)	`TAGGGG/TTTGGG`	1	--	ng5¹		0	--	--	--	--
	rs4278201^1,2	H	5447212(+)	`GATAAG/AAACAT`	1	K/K	syn¹ ese³		4		EU EA WA	418
	rs866066^1,2	A,C,F,H,O	5440953(-)	`AGCTGG/ACGGTG`	1	--	int¹		7		NA EA EU WA	658
	rs2282055^1,2	A,C,F,H,O	5445732(-)	`TACAAA/CATTTC`	1	--	int¹		12		EA NA EU WA	2410

About this table

HapMap Linkage Disequilibrium images for CD274 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605402

10/22 Novoseek disease relationships for CD274 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumor escape	51.47	1	19380770 (1)
lupus nephritis	48.57	2	16386962 (1), 15885642 (1)
autoimmune diseases	42.18	4	19081139 (1), 11323285 (1), 15599732 (1), 12721664 (1)
hepatitis b chronic	38.52	8	18705009 (3), 17963598 (3), 18578991 (2)
autoimmunity	32.48	1	11015443 (1)
tumors	32.25	92	17239274 (6), 17186290 (5), 17340590 (5), 15297412 (4) (see all 31)
virus infection	26.36	9	16876901 (2), 19075244 (2), 14686489 (1), 17195077 (1) (see all 6)
cancer	26.23	43	17186290 (5), 12721664 (3), 16413538 (2), 17195077 (2) (see all 15)
hepatitis autoimmune	25.13	2	16876901 (1)
renal cancer	21.82	2	17239274 (1), 17340590 (1)

About this table

Human Genome Epidemiology Navigator: CD274 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/156 PubMed articles for CD274 gene (see all 156 ):

Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PubMed id 11015443)^{1, 2, 3, 4} Freeman G.J.... Honjo T. (2000)
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PubMed id 10581077)^{2, 3, 4} Dong H....Chen L. (1999)
Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PubMed id 15780196)^{1, 3, 4} He X.-H.... Liu Y. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. (PubMed id 15342209)^{1, 3} Schreiner B....Wiendl H. (2004)
Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. (PubMed id 17186290)^{1, 3} Nakanishi J....Ueda S. (2007)
Interaction of human PD-L1 and B7-1. (PubMed id 18585785)^{1, 3} Butte M.J....Sharpe A.H. (2008)
Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia. (PubMed id 18756622)^{1, 3} Chen X....Ma X. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 29126	HGNC: 17635	AceView: PDCD1LG1	Ensembl:ENSG00000120217	euGenes: HUgn29126
ECgene: CD274	H-InvDB: CD274

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CD274
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD274:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD274-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD274		Antibodies for CD274
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CD274		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD274)
	Antibodies (CD274)
	Chimera RNAi (CD274)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD274)
	Antibodies (CD274)

Search OriGene for CD274

Search Tocris compounds for CD274

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CD274

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CD274 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CD274 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for CD274

Summaries
for CD274

Genomic Location
for CD274

Proteins
for CD274

Protein Domains/
Families
for CD274

Gene Function
for CD274

Pathways & Interactions
for CD274

Drugs & Compounds
for CD274

Transcripts
for CD274

Expression
for CD274

Orthologs
for CD274

Paralogs
for CD274

SNPs/Variants
for CD274

Disorders & Mutations
for CD274

Medical News
for CD274

Publications
for CD274

Search for CD274

Genome Databases showing CD274

Other Databases showing CD274

Specialized Databases showing CD274

Licensable Technologies
for CD274

Services
for CD274

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD274 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor CD274

Summariesfor CD274

Genomic Locationfor CD274

Proteinsfor CD274

Protein Domains/Familiesfor CD274

Gene Functionfor CD274

Pathways & Interactionsfor CD274

Drugs & Compoundsfor CD274

Transcriptsfor CD274

Expression for CD274

Orthologsfor CD274

Paralogsfor CD274

SNPs/Variantsfor CD274

Disorders & Mutationsfor CD274

Medical Newsfor CD274

Publicationsfor CD274

Search for CD274

Genome Databases showing CD274

Other Databases showing CD274

Specialized Databases showing CD274

Licensable Technologiesfor CD274

Servicesfor CD274

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD274

Summaries
for CD274

Genomic Location
for CD274

Proteins
for CD274

Protein Domains/
Families
for CD274

Gene Function
for CD274

Pathways & Interactions
for CD274

Drugs & Compounds
for CD274

Transcripts
for CD274

Expression
for CD274

Orthologs
for CD274

Paralogs
for CD274

SNPs/Variants
for CD274

Disorders & Mutations
for CD274

Medical News
for CD274

Publications
for CD274

Licensable Technologies
for CD274

Services
for CD274