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Aliases for CD274 Gene

Aliases for CD274 Gene

  • CD274 Molecule 2 3
  • CD274 Antigen 2 3 4
  • B7 Homolog 1 2 3 4
  • PDCD1LG1 3 4 6
  • B7H1 3 4 6
  • Programmed Cell Death 1 Ligand 1 2 3
  • Programmed Death Ligand 1 3 4
  • PDCD1 Ligand 1 3 4
  • PDCD1L1 3 4
  • PD-L1 3 4
  • PDL1 3 4
  • B7-H1 4
  • B7-H 3

External Ids for CD274 Gene

Previous Symbols for CD274 Gene

  • PDCD1LG1

Summaries for CD274 Gene

GeneCards Summary for CD274 Gene

CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include primary mediastinal large b-cell lymphoma and cheilitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and CD28 co-stimulation. An important paralog of this gene is PDCD1LG2.

UniProtKB/Swiss-Prot for CD274 Gene

  • Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Gene Wiki entry for CD274 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD274 Gene

Genomics for CD274 Gene

Genomic Location for CD274 Gene

5,450,399 bp from pter
5,470,567 bp from pter
20,169 bases
Plus strand

Genomic View for CD274 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD274 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD274 Gene

Regulatory Elements for CD274 Gene

Proteins for CD274 Gene

  • Protein details for CD274 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Programmed cell death 1 ligand 1
    Protein Accession:
    Secondary Accessions:
    • B2RBA2
    • B4DU27
    • Q14CJ2
    • Q2V8D5
    • Q66RK1
    • Q6WEX4
    • Q9NUZ5

    Protein attributes for CD274 Gene

    290 amino acids
    Molecular mass:
    33275 Da
    Quaternary structure:
    • Interacts with PDCD1.
    • Sequence=BAA91966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD274 Gene

    Alternative splice isoforms for CD274 Gene


neXtProt entry for CD274 Gene

Proteomics data for CD274 Gene at MOPED

Post-translational modifications for CD274 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn35, Asn192, Asn200, and Asn219

Other Protein References for CD274 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD274 Gene

Domains for CD274 Gene

Gene Families for CD274 Gene

  • ENDOLIG :Endogenous ligands
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Protein Domains for CD274 Gene


  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q9NZQ7
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9NZQ7
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.:
    • Q9NZQ7
genes like me logo Genes that share domains with CD274: view

Function for CD274 Gene

Molecular function for CD274 Gene

UniProtKB/Swiss-Prot Function: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

Gene Ontology (GO) - Molecular Function for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD274: view
genes like me logo Genes that share phenotypes with CD274: view

Animal Models for CD274 Gene

MGI Knock Outs for CD274:

miRNA for CD274 Gene

miRTarBase miRNAs that target CD274

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD274 Gene

Localization for CD274 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD274 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD274 Gene COMPARTMENTS Subcellular localization image for CD274 gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 17076679
genes like me logo Genes that share ontologies with CD274: view

Pathways for CD274 Gene

genes like me logo Genes that share pathways with CD274: view

Pathways by source for CD274 Gene

1 KEGG pathway for CD274 Gene

Gene Ontology (GO) - Biological Process for CD274 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 10581077
GO:0007165 signal transduction IDA 10581077
GO:0007166 cell surface receptor signaling pathway IDA 10581077
GO:0031295 T cell costimulation TAS --
GO:0032689 negative regulation of interferon-gamma production IMP 12538684
genes like me logo Genes that share ontologies with CD274: view

Compounds for CD274 Gene

(3) Novoseek inferred chemical compound relationships for CD274 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 10.8 1
nitric oxide 0 2
dexamethasone 0 1
genes like me logo Genes that share compounds with CD274: view

Transcripts for CD274 Gene

Unigene Clusters for CD274 Gene

CD274 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD274 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CD274 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD274 Gene

mRNA expression in normal human tissues for CD274 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD274 Gene

SOURCE GeneReport for Unigene cluster for CD274 Gene Hs.521989

mRNA Expression by UniProt/SwissProt for CD274 Gene

Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
genes like me logo Genes that share expressions with CD274: view

Orthologs for CD274 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD274 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD274 36
  • 99.54 (n)
  • 99.66 (a)
CD274 37
  • 100 (a)
(Bos Taurus)
Mammalia CD274 36
  • 83.1 (n)
  • 73.96 (a)
PD-L1 37
  • 73 (a)
(Canis familiaris)
Mammalia CD274 36
  • 83.97 (n)
  • 77 (a)
CD274 37
  • 76 (a)
(Mus musculus)
Mammalia Cd274 36
  • 76.36 (n)
  • 69.9 (a)
Cd274 16
Cd274 37
  • 69 (a)
(Monodelphis domestica)
Mammalia CD274 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia CD274 37
  • 51 (a)
(Rattus norvegicus)
Mammalia Cd274 36
  • 76.59 (n)
  • 70.24 (a)
(Gallus gallus)
Aves CD274 36
  • 55.9 (n)
  • 47.09 (a)
CD274 37
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd274 36
  • 49.49 (n)
  • 37.44 (a)
(Danio rerio)
Actinopterygii CD274 37
  • 15 (a)
si:ch211-241b2.5 36
  • 46.77 (n)
  • 30.8 (a)
Species with no ortholog for CD274:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD274 Gene

Gene Tree for CD274 (if available)
Gene Tree for CD274 (if available)

Paralogs for CD274 Gene

Paralogs for CD274 Gene

Selected SIMAP similar genes for CD274 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD274: view

Variants for CD274 Gene

Sequence variations from dbSNP and Humsavar for CD274 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs822336 -- 5,448,690(+) GAGCA(C/G)CAAGC upstream-variant-2KB
rs822337 -- 5,449,154(+) GTACC(A/T)GTAAA upstream-variant-2KB
rs822338 -- 5,451,557(+) AATGA(C/T)AGTCG intron-variant
rs822339 -- 5,453,172(-) TTTCT(C/T)TCCTT intron-variant
rs822340 -- 5,453,260(-) ATGAG(C/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD274 Gene

Variant ID Type Subtype PubMed ID
nsv892141 CNV Gain 21882294
dgv2277e1 CNV Complex 17122850
nsv466108 CNV Gain 19166990
nsv519771 CNV Loss 19592680
nsv509292 CNV Insertion 20534489

Relevant External Links for CD274 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CD274 Gene

(1) University of Copenhagen DISEASES for CD274 Gene

(22) Novoseek inferred disease relationships for CD274 Gene

Disease -log(P) Hits PubMed IDs
tumor escape 46.9 1
lupus nephritis 43.7 2
hepatitis b chronic 42.6 9
autoimmune diseases 41.2 7
tumors 40.1 85

Relevant External Links for CD274

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD274: view

No data available for UniProtKB/Swiss-Prot for CD274 Gene

Publications for CD274 Gene

  1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PMID: 11015443) Freeman G.J. … Honjo T. (J. Exp. Med. 2000) 2 3 4 23
  2. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PMID: 15780196) He X.-H. … Liu Y. (Acta Pharmacol. Sin. 2005) 3 4 23
  3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PMID: 18322304) Hayashi M. … Komiya I. (Eur. J. Endocrinol. 2008) 3 23 49
  4. Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (PMID: 19850680) Mitchell A.L. … Pearce S.H. (J. Clin. Endocrinol. Metab. 2009) 3 23 49
  5. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PMID: 10581077) Dong H. … Chen L. (Nat. Med. 1999) 2 3 4

Products for CD274 Gene

Sources for CD274 Gene

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