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CD274 Gene

protein-coding   GIFtS: 62
GCID: GC09P005444

CD274 Molecule

(Previous names: programmed cell death 1 ligand 1, CD274 antigen)
(Previous symbol: PDCD1LG1)
  See CD274-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD274 Molecule1 2     PD-L12 3
PDCD1LG11 2 3 5     PDCD1L12 3
B7 Homolog 11 2 3     PDL12 3
CD274 Antigen1 2 3     PDCD1 Ligand 12 3
B7H12 3 5     B7-H2
Programmed Cell Death 1 Ligand 11 2     B7-H13
Programmed Death Ligand 12 3     

External Ids:    HGNC: 176351   Entrez Gene: 291262   Ensembl: ENSG000001202177   OMIM: 6054025   UniProtKB: Q9NZQ73   

Export aliases for CD274 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD274 Gene:
CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include actinic cheilitis, and cheilitis. An important paralog of this gene is PDCD1LG2.

UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7
Function: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and
IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation
and cytokine production

Gene Wiki entry for CD274 (PD-L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD274 gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD274 promoter sequence
   Search Chromatin IP Primers for CD274

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD274


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

CD274 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD274 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005444:  view genomic region     (about GC identifiers)

Start:
5,450,503 bp from pter      End:
5,470,567 bp from pter
Size:
20,065 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7 (See protein sequence)
Recommended Name: Programmed cell death 1 ligand 1 precursor  
Size: 290 amino acids; 33275 Da
Subunit: Interacts with PDCD1
Sequence caution: Sequence=BAA91966.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for CD274:
3BIK (3D)        3BIS (3D)        3FN3 (3D)        3SBW (3D)    
Secondary accessions: B2RBA2 B4DU27 Q14CJ2 Q66RK1 Q6WEX4 Q9NUZ5
Alternative splicing: 3 isoforms:  Q9NZQ7-1   Q9NZQ7-2   Q9NZQ7-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD274: NX_Q9NZQ7

Explore proteomics data for CD274 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35, Asn192, Asn200, Asn219
  • Modification sites at PhosphoSitePlus

  • See CD274 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254635.1  NP_054862.1  

    ENSEMBL proteins: 
     ENSP00000370989   ENSP00000370985  
    Reactome Protein details: Q9NZQ7

    CD274 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CD274
    OriGene Protein Over-expression Lysate for CD274
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CD274
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    Novus Biologicals CD274 Proteins
    Novus Biologicals CD274 Lysate
    Sino Biological Recombinant Protein for CD274
    Sino Biological Cell Lysate for CD274
    ProSpec Recombinant Protein for CD274
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD274 

     
    antibodies-online proteins for CD274 (21 products) 

     
    antibodies-online peptides for CD274

    CD274 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD274
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    Novus Biologicals CD274 Antibodies
    Abcam antibodies for CD274
    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for CD274 (162 products) 

    CD274 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD274 
    antibodies-online kits for CD274 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    ENDOLIG: Endogenous ligands
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NZQ7

    ProtoNet protein and cluster: Q9NZQ7

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD274           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PD1L1_HUMAN, Q9NZQ7
    Function: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and
    IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation
    and cytokine production
    Induction: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG
    activation. Up-regulated in B-cells activated by surface Ig cross-linking

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CD274           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cd274):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with CD274           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD274: Cd274tm1.1Lex Cd274tm1Shr Cd274tm1Lpc Cd274tm2Shr

       genOway: Develop your customized and physiologically relevant rodent model for CD274

    miRNA
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    miRTarBase miRNAs that target CD274:
    hsa-mir-16-5p (MIRT031920), hsa-mir-513a-5p (MIRT003923), hsa-mir-103a-3p (MIRT027156)

    Block miRNA regulation of human, mouse, rat CD274 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD274 (see all 36):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-548j hsa-miR-106a hsa-miR-93 hsa-miR-155 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD274 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD274
    Predesigned siRNA for gene silencing in human, mouse, rat CD274

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CD274 (see all 6)
    OriGene ORF clones in mouse, rat for CD274
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    GenScript: all cDNA clones in your preferred vector: CD274 (NM_014143)
    Sino Biological Human cDNA Clone for CD274
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD274
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD274

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD274

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11553 VA1-14281 VA4-12443) for CD274 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PD1L1_HUMAN, Q9NZQ7: Isoform 1: Cell membrane; Single-pass type I membrane protein
    PD1L1_HUMAN, Q9NZQ7: Isoform 2: Endomembrane system; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    peroxisome2
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA17076679

    Find genes that share ontologies with CD274           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD274 About    
    See pathways by source

    SuperPathContained pathways About
    1Translocation of ZAP-70 to Immunological synapse
    PD-1 signaling0.72
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with CD274           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD274
        PD-1 signaling


    1 Kegg Pathway  (Kegg details for CD274):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Array including CD274: 
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD274

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD274 (Q9NZQ71, 3 ENSP000003709894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD1Q151161, 3, ENSP000003350624EBI-4314282,EBI-4314328 I2D: score=4 STRING: ENSP00000335062
    CD80P336811, ENSP000002642464EBI-4314282,EBI-1031024 STRING: ENSP00000264246
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IDA10581077
    GO:0007165signal transduction IDA10581077
    GO:0007166cell surface receptor signaling pathway IDA10581077
    GO:0031295T cell costimulation TAS--
    GO:0042102positive regulation of T cell proliferation TAS10581077

    Find genes that share ontologies with CD274           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD274 (PD1L1)

    3 Novoseek inferred chemical compound relationships for CD274 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 10.8 1 15780196 (1)
    nitric oxide 0 7 16606666 (1), 17161871 (1)
    dexamethasone 0 1 16293609 (1)



    Find genes that share compounds with CD274           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD274 gene (2 alternative transcripts): 
    NM_001267706.1  NM_014143.3  

    Unigene Cluster for CD274:

    CD274 molecule
    Hs.521989  [show with all ESTs]
    Unigene Representative Sequence: NM_014143
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381577(uc011lmb.2 uc003zje.3 uc010mhn.3) ENST00000498261
    ENST00000474218 ENST00000492923 ENST00000381573(uc003zjf.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD274 (see all 36):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-548j hsa-miR-106a hsa-miR-93 hsa-miR-155 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD274 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CD274
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF177937.1 AF233516.1 AK001894.1 AK300470.1 AK314567.1 AY254342.1 AY291313.1 AY714881.1 
    BC069381.1 BC074984.2 BC113734.1 BC113736.1 DQ286582.1 DQ836393.1 NR_052005.1 

    11 DOTS entries:

    DT.121168514  DT.100712902  DT.95134823  DT.441589  DT.100831039  DT.101981824  DT.203629  DT.423576 
    DT.121168576  DT.40281578  DT.91904332 

    Selected AceView cDNA sequences (see all 92):

    BG542122 BC069381 BQ013314 CA309674 AU134845 BU621474 AF177937 BF060780 
    AK001894 BX351715 BQ012403 CK904743 BE043008 AY714881 AA399416 CF529178 
    NM_014143 AU136409 AF233516 BU629434 AY291313 CF529106 AI678841 BX399016 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD274    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                                                                        
    SP2:                                      -                 -               
    SP3:                          -                                             
    SP4:              -     -                                                   


    ECgene alternative splicing isoforms for CD274

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD274 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTATTTGT
    CD274 Expression
    About this image


    CD274 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Placenta (Extraembryonic Tissues)
    CD274 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD274 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521989

    UniProtKB/Swiss-Prot: PD1L1_HUMAN, Q9NZQ7
    Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the
    thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and
    monocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including CD274: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD274

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD274 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2741 , 5 CD274 antigen1, 5 76.36(n)1
    69.9(a)1
      19 (23.88 cM)5
    605331  NM_021893.31  NP_068693.11 
     293674555 
    chicken
    (Gallus gallus)
    Aves CD2741 CD274 molecule 55.9(n)
    47.09(a)
      427224  XM_424811.4  XP_424811.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cd2741 CD274 molecule 49.49(n)
    37.44(a)
      101731191  XM_004911407.1  XP_004911464.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-241b2.51 si:ch211-241b2.5 46.77(n)
    30.8(a)
      100536137  XM_003200807.2  XP_003200855.2 


    ENSEMBL Gene Tree for CD274 (if available)
    TreeFam Gene Tree for CD274 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD274 gene
    PDCD1LG22  
    3 SIMAP similar genes for CD274 using alignment to 2 protein entries:     PD1L1_HUMAN (see all proteins):
    PDL2    PDCD1LG2    CD276

    Find genes that share paralogs with CD274           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD274 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504392311,2
    --5448539(+) TAATAA/GAATTT 3 -- us2k10--------
    rs1382616401,2
    --5448573(+) TTTTCA/CATCTC 3 -- us2k10--------
    rs1429834881,2
    --5448634(+) AGGTGG/TGAAAG 3 -- us2k10--------
    rs767414681,2
    C,F--5448641(+) AAAGAT/CGAACA 3 -- us2k11Minor allele frequency- C:0.09WA 118
    rs8223361,2
    C,F,A,H--5448690(+) GAGCAG/CCAAGC 3 -- us2k116Minor allele frequency- C:0.37NS EA NA CSA WA 1146
    rs1834006201,2
    --5448763(+) TGATCA/GTTTAG 3 -- us2k10--------
    rs1872528321,2
    --5448815(+) CCCATA/CCCCAG 3 -- us2k10--------
    rs1461439761,2
    --5448859(+) CTAGGA/GGGATA 3 -- us2k10--------
    rs1390237651,2
    --5448896(+) TTATTG/TGCCCA 3 -- us2k10--------
    rs736416151,2
    C,F--5448956(+) TTTTGT/CTTTGT 3 -- us2k14Minor allele frequency- C:0.11WA CSA NA 242

    HapMap Linkage Disequilibrium report for CD274 (5450503 - 5470567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD274:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509292CNV Insertion20534489
    nsv519771CNV Loss19592680
    nsv466108CNV Gain19166990
    nsv892141CNV Gain21882294
    dgv2277e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD274
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CD274
    DNA2.0 Custom Variant and Variant Library Synthesis for CD274

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605402    OMIM disorders: --

    9 diseases for CD274:    
    About MalaCards
    actinic cheilitis    cheilitis    autoimmune myocarditis    primary mediastinal large b-cell lymphoma
    pulmonary venoocclusive disease    tropical spastic paraparesis    spastic paraparesis    lupus nephritis
    myocarditis

    1 disease from the University of Copenhagen DISEASES database for CD274:
    Pulmonary venoocclusive disease

    Find genes that share disorders with CD274           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD274 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumor escape 46.9 1 19380770 (1)
    lupus nephritis 43.7 2 16386962 (1), 15885642 (1)
    hepatitis b chronic 42.6 10 18705009 (3), 17963598 (3), 18578991 (2), 19811426 (1)
    autoimmune diseases 41.2 8 19499529 (2), 19081139 (1), 11323285 (1), 15599732 (1) (see all 6)
    tumors 40.1 115 17239274 (6), 17186290 (5), 17340590 (5), 15297412 (4) (see all 43)
    cancer 34.7 46 17186290 (5), 12721664 (3), 16413538 (2), 17195077 (2) (see all 18)
    autoimmunity 31.5 1 11015443 (1)
    virus infection 28.9 12 16876901 (2), 19955307 (2), 19075244 (2), 14686489 (1) (see all 8)
    hepatitis autoimmune 19.6 2 16876901 (1)
    glioma 16.8 9 14612546 (5), 17159987 (3)

    Genetic Association Database (GAD): CD274
    Human Genome Epidemiology (HuGE) Navigator: CD274 (10 documents)

    Export disorders for CD274 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CD274 gene, integrated from 10 sources (see all 323):
    (articles sorted by number of sources associating them with CD274)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation. (PubMed id 11015443)1, 2, 3, 9 Freeman G.J.... Honjo T. (J. Exp. Med. 2000)
    2. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. (PubMed id 10581077)1, 2, 3 Dong H.... Chen L. (Nat. Med. 1999)
    3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PubMed id 18322304)1, 4, 9 Hayashi M....Komiya I. (Eur. J. Endocrinol. 2008)
    4. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. (PubMed id 15780196)1, 2, 9 He X.-H.... Liu Y. (Acta Pharmacol. Sin. 2005)
    5. Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (PubMed id 19850680)1, 4, 9 Mitchell A.L....Pearce S.H. (J. Clin. Endocrinol. Metab. 2009)
    6. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. (PubMed id 17203303)1, 4, 9 Ni R....Hara T. (Hum. Genet. 2007)
    7. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (Hum. Genet. 2010)
    8. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    9. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    10. Polymorphisms of genes for programmed cell death 1 ligands in patients with rheumatoid arthritis. (PubMed id 17597384)1, 4 Wang S.C....Yen J.H. (J. Clin. Immunol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29126 HGNC: 17635 AceView: PDCD1LG1 Ensembl:ENSG00000120217 euGenes: HUgn29126
    ECgene: CD274 Kegg: 29126 H-InvDB: CD274

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD274 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CD274 gene:
    Search GeneIP for patents involving CD274

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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