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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD27 Gene

protein-coding   GIFtS: 63
GCID: GC12P006554

CD27 Molecule

(Previous names: tumor necrosis factor receptor superfamily, member 7)
(Previous symbol: TNFRSF7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD27 Molecule1 2     T-Cell Activation Antigen CD272 3
TNFRSF71 2 3 5     S1522 5
Tumor Necrosis Factor Receptor Superfamily, Member 71 2     Tp552
T142 3     S152. LPFS22
CD27 Antigen2 3     T Cell Activation Antigen S1522
CD27L Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 73

External Ids:    HGNC: 119221   Entrez Gene: 9392   Ensembl: ENSG000001391937   OMIM: 1867115   UniProtKB: P268423   

Export aliases for CD27 gene to outside databases

Previous GC identifer: GC12P006425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD27 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for
generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in
regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the
activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling
process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is
thought to play an important role in the apoptosis induced by this receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD27 Gene: 
CD27 (CD27 molecule) is a protein-coding gene. Diseases associated with CD27 include pars planitis, and tetanus, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.

UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis
through association with SIVA1

Gene Wiki entry for CD27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD27 gene promoter:
         GR   AML1a   p53   GR-beta   HSF1 (long)   FOXO4   HSF1short   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD27 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD27 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006554:  view genomic region     (about GC identifiers)

Start:
6,554,033 bp from pter      End:
6,560,884 bp from pter
Size:
6,852 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD27_HUMAN, P26842 (See protein sequence)
Recommended Name: CD27 antigen precursor  
Size: 260 amino acids; 29137 Da
Subunit: Homodimer. Interacts with SIVA1 and TRAF2
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2RDZ0

Explore the universe of human proteins at neXtProt for CD27: NX_P26842

Explore proteomics data for CD27 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated
  • UniProtKB: O-glycosylated with core 1 or possibly core 8 glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26842

  • CD27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD27 Protein Expression
    REFSEQ proteins: NP_001233.1  
    ENSEMBL proteins: 
     ENSP00000266557  

    Human Recombinant Protein Products for CD27: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD27 (CD27/TNFRSF7)
    Enzo Life Sciences proteins for CD27
    OriGene Purified Protein for CD27
    OriGene Protein Over-expression Lysate for CD27
    OriGene MassSpec for CD27 
    OriGene Custom Protein Services for CD27
    GenScript Custom Purified and Recombinant Proteins Services for CD27
    Novus Biologicals CD27 Proteins
    Novus Biologicals CD27 Lysates
    Sino Biological Recombinant Protein for CD27
    Sino Biological Cell Lysate for CD27 
    ProSpec Recombinant Protein for CD27
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12624711
    GO:0005887integral to plasma membrane NAS12324477
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016020membrane ----

    CD27 for ontologies           About GeneDecksing



    CD27 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD27
    R&D Systems Antibodies for CD27 (CD27/TNFRSF7)
    OriGene Antibodies for CD27
    OriGene Custom Antibody Services for CD27
    GenScript Custom Superior Antibodies Services for CD27
    Novus Biologicals CD27 Antibodies
    Abcam antibodies for CD27
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD27
    LSBio Antibodies in human, mouse, rat for CD27 

    Assay Products for CD27: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD27
    R&D Systems Multiplex/Array Assay Kits & Reagents for CD27 (CD27/TNFRSF7)
    GenScript Custom Assay Services for CD27
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD27 
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR022328 TNFR_7
     IPR001368 TNFR/NGFR_Cys_rich_reg

    Graphical View of Domain Structure for InterPro Entry P26842

    ProtoNet protein and cluster: P26842

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
    Similarity: Contains 3 TNFR-Cys repeats


    CD27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD27_HUMAN, P26842
    Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis
    through association with SIVA1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS14556986
    GO:0005515protein binding IPI12324477
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA12324477
         
    CD27 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD27:
     Downregulation of NF-kappaB pa  Increased cell number in G2M,  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd27):
     hematopoietic system  immune system 

    CD27 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd27tm1Jbo for CD27

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD27 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD27 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD27 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD27
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD27
    SwitchGear 3'UTR luciferase reporter plasmidCD27 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD27

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CD27

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD27 (see all 7)
    OriGene ORF clones in mouse, rat for CD27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD27 (NM_001242)
    Sino Biological Human cDNA Clone for CD27
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD27
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                         Customized lentivirus expression plasmids for stable overexpression of CD27 

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    Search LifeMap BioReagents cell lines for CD27
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD27 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Apoptotic TNF-family pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CD27
        Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for CD27
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions


    1 GeneGo (Thomson Reuters) Pathway for CD27
        Apoptosis and survival Apoptotic TNF-family pathways

    3 Sino Biological Pathways for CD27 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for CD27):
        Cytokine-cytokine receptor interaction


    CD27 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for CD27 (P268421, 3 ENSP000002665574) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIVA1O153041, 3, ENSP000003292134EBI-520729,EBI-520756 I2D: score=5 STRING: ENSP00000329213
    TRAF5O004633, ENSP000002614644I2D: score=3 STRING: ENSP00000261464
    CD70P329703, ENSP000002459034I2D: score=2 STRING: ENSP00000245903
    CD5P061273, ENSP000003426814I2D: score=1 STRING: ENSP00000342681
    UHRF2Q96PU43, ENSP000002768934I2D: score=1 STRING: ENSP00000276893
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway NAS14556986
    GO:0008588release of cytoplasmic sequestered NF-kappaB NAS12324477
    GO:0016064immunoglobulin mediated immune response NAS14556986
    GO:0043066negative regulation of apoptotic process IDA12324477
    GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA12324477

    CD27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD27 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD27

    1 IUPHAR Ligand for CD27 (CD27)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CD70
    NoneNone--

    4 Novoseek inferred chemical compound relationships for CD27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 57.7 1 15708970 (1)
    calcium 4.09 1 1707907 (1)
    serine 0 2 1707907 (1)
    cysteine 0 2 16272303 (1), 1334106 (1)

    Search CenterWatch for drugs/clinical trials and news about CD27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD27 gene: 
    NM_001242.4  

    Unigene Cluster for CD27:

    CD27 molecule
    Hs.355307  [show with all ESTs]
    Unigene Representative Sequence: BC012160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266557(uc001qod.3) ENST00000541233
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD27
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD27
    SwitchGear 3'UTR luciferase reporter plasmidCD27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD27
    Clone
    Products:
         
    OriGene clones in human, mouse for CD27 (see all 7)
    OriGene ORF clones in mouse, rat for CD27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD27 (NM_001242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD27
    Sirion Biotech Customized lentivirus for stable overexpression of CD27 
                         Customized lentivirus expression plasmids for stable overexpression of CD27 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD27
    OriGene qSTAR qPCR primer pairs in human, mouse for CD27
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD27

    Additional mRNA sequence: 

    AK315732.1 BC012160.1 M63928.1 

    8 DOTS entries:

    DT.112205  DT.121214753  DT.95170259  DT.100704011  DT.100772134  DT.97836572  DT.100778648  DT.97862728 

    4 AceView cDNA sequences:

    CR618820 NM_001242 M63928 BC012160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD27 expression in normal human tissues (normalized intensities)      CD27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACTCTGG
    CD27 Expression
    About this image


    CD27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             T-Cytotoxic Cells Peripheral Blood
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 4 entries
             T-Cytotoxic Cells Thymus
             Thymus
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   

    See CD27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD27

    SOURCE GeneReport for Unigene cluster: Hs.355307

    UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
    Tissue specificity: Found in most T-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD27 (see all 9): 
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th1/Th2 Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD27 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd271 , 5 CD27 antigen1, 5 76.8(n)1
    67.2(a)1
      6 (59.32 cM)5
    219401  NM_001033126.21  NP_001028298.11 
     1252326225 
    zebrafish
    (Danio rerio)
    Actinopterygii CR533575.16
    Uncharacterized protein
    21(a)
    1 ↔ 1
    16(19152035-19162767)


    ENSEMBL Gene Tree for CD27 (if available)
    TreeFam Gene Tree for CD27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/288 SNPs in CD27 are shown (see all 288)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0523484
    ----see VAR_0523482 H R mis40--------
    rs37593411,2
    C,F--6483414(+) TACTCA/GGGAGG 1 -- us2k16Minor allele frequency- G:0.42NA WA EA 364
    rs1996464731,2
    C--6483462(+) GTTGC-/AGTGAG 1 -- us2k10--------
    rs1898179401,2
    --6483477(+) GATTGC/TATCAT 1 -- us2k10--------
    rs123027681,2
    C,F,H--6483540(+) AGGAAG/AGTCCC 1 -- us2k1 trp34Minor allele frequency- A:0.06NS WA EA 460
    rs31365501,2
    C,F,A,H--6483544(+) AGGTCC/TCGTCC 1 -- us2k118Minor allele frequency- T:0.25NA NS EA WA 2372
    rs115693511,2
    C,F,H--6483672(+) TTGGCC/TGAGGC 1 -- us2k16Minor allele frequency- T:0.03NS EA WA 688
    rs30872751,2
    H--6483723(+) CCCTGG/AAGAAG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs22865981,2
    C,F,A,H--6483776(-) CCTAAC/GGCTGC 1 -- us2k125Minor allele frequency- G:0.46EA NA NS WA CSA 3349
    rs1397596471,2
    C--6483801(+) CCAGTA/CGGTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD27 (6554033 - 6560884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CD27:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8894CNV Gain18304495
    esv34390CNV Gain17911159
    esv34325CNV Gain17911159
    nsv818881CNV Gain17921354
    essv12131CNV CNV17122850
    nsv442252CNV CNV18776908
    dgv453e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CD27
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD27
    DNA2.0 Custom Variant and Variant Library Synthesis for CD27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186711    OMIM disorders: --

    20/53 diseases for CD27 (see all 53):    About MalaCards
    pars planitis    tetanus    follicular lymphoma    plasmacytoma
    oral lichen planus    human immunodeficiency virus infectious disease    common variable immunodeficiency    filariasis
    pulmonary sarcoidosis    mixed cryoglobulinemia    waldenstrom macroglobulinemia    macroglobulinemia
    interstitial lung disease    cryoglobulinemia    aids dementia complex    lichen planus
    burkitt's lymphoma    pulmonary tuberculosis    sarcoidosis    agammaglobulinemia

    4 diseases from the University of Copenhagen DISEASES database for CD27:
    Common variable immunodeficiency     Lymphoma     Human immunodeficiency virus infectious disease     Systemic lupus erythematosus

    CD27 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/26 Novoseek inferred disease relationships for CD27 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 57.2 33 9582383 (2), 10809378 (1), 11980654 (1), 17182676 (1) (see all 30)
    lymphoma small lymphocytic 52.4 1 12685844 (1)
    common variable immunodeficiency 44.5 1 16413828 (1)
    leukemia b-cell 43.2 1 7540066 (1)
    leukemia lymphocytic chronic 41.7 3 12685844 (1), 7540066 (1), 10221513 (1)
    lymphoma 39.1 17 12685844 (4), 1940802 (3), 10419648 (3), 9824099 (2) (see all 6)
    lymphocytic leukemia chronic b-cell 39 3 17526459 (2), 7540066 (1)
    lymphoma follicular 38.9 1 12685844 (1)
    tumors 37.2 31 9582383 (2), 9622100 (2), 10809378 (1), 11980654 (1) (see all 27)
    plasmacytoma 33.3 3 12685844 (1), 7540066 (1)

    Genetic Association Database (GAD): CD27
    Human Genome Epidemiology (HuGE) Navigator: CD27 (10 documents)

    Export disorders for CD27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD27 gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with CD27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. (PubMed id 1655907)1, 2, 9 Camerini D.... Seed B. (1991)
    2. Genomic organization and chromosomal localization of the human CD27 gene. (PubMed id 1334106)1, 2, 9 Loenen W.A....Borst J. (1992)
    3. Isolation and regional assignment of human chromosome 12p cDNAs. (PubMed id 8530100)1, 3, 9 Baens M....Marynen P. (1995)
    4. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    5. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. (PubMed id 18774388)1, 4 Tremblay K....Laprise C. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. (PubMed id 9692890)1, 2 Gravestein L.A....Borst J. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 939 HGNC: 11922 AceView: TNFRSF7 Ensembl:ENSG00000139193 euGenes: HUgn939
    ECgene: CD27 Kegg: 939 H-InvDB: CD27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD27 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD27 gene:
    Search GeneIP for patents involving CD27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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