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CD27 Gene

protein-coding   GIFtS: 64
GCID: GC12P006554

CD27 Molecule

(Previous names: tumor necrosis factor receptor superfamily, member 7)
(Previous symbol: TNFRSF7)
  See CD27-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD27 Molecule1 2     T-Cell Activation Antigen CD272 3
TNFRSF71 2 3 5     S152. LPFS22 5
Tumor Necrosis Factor Receptor Superfamily, Member 71 2     S1522
T142 3     Tp552
CD27 Antigen2 3     T Cell Activation Antigen S1522
CD27L Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 73

External Ids:    HGNC: 119221   Entrez Gene: 9392   Ensembl: ENSG000001391937   OMIM: 1867115   UniProtKB: P268423   

Export aliases for CD27 gene to outside databases

Previous GC identifer: GC12P006425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD27 Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for
generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in
regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the
activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling
process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is
thought to play an important role in the apoptosis induced by this receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD27 Gene:
CD27 (CD27 molecule) is a protein-coding gene. Diseases associated with CD27 include lymphoproliferative syndrome 2, and pars planitis. GO annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.

UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis
through association with SIVA1

Gene Wiki entry for CD27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD27 gene promoter:
         GR   AML1a   p53   GR-beta   HSF1 (long)   FOXO4   HSF1short   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD27 promoter sequence
   Search Chromatin IP Primers for CD27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD27 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006554:  view genomic region     (about GC identifiers)

Start:
6,554,033 bp from pter      End:
6,560,884 bp from pter
Size:
6,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD27_HUMAN, P26842 (See protein sequence)
Recommended Name: CD27 antigen precursor  
Size: 260 amino acids; 29137 Da
Subunit: Homodimer. Interacts with SIVA1 and TRAF2
Secondary accessions: B2RDZ0

Explore the universe of human proteins at neXtProt for CD27: NX_P26842

Explore proteomics data for CD27 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Asn95, Ser127
  • Modification sites at PhosphoSitePlus

  • See CD27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001233.1  
    ENSEMBL proteins: 
     ENSP00000266557  

    CD27 Human Recombinant Protein Products:

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    Novus Biologicals CD27 Proteins
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    Sino Biological Recombinant Protein for CD27
    Sino Biological Cell Lysate for CD27
    ProSpec Recombinant Protein for CD27
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD27 

    CD27 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD27
    R&D Systems Antibodies for CD27 (CD27/TNFRSF7)
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    Abcam antibodies for CD27
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    LSBio Antibodies in human, mouse, rat for CD27

    CD27 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CD27:  
                        Human sCD27 Instant ELISA 128 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: CD27
    Tumour necrosis factor (TNF) receptor family

    2 InterPro protein domains:
     IPR022328 TNFR_7
     IPR001368 TNFR/NGFR_Cys_rich_reg

    Graphical View of Domain Structure for InterPro Entry P26842

    ProtoNet protein and cluster: P26842

    1 Blocks protein domain: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

    UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
    Similarity: Contains 3 TNFR-Cys repeats


    Find genes that share domains with CD27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD27_HUMAN, P26842
    Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis
    through association with SIVA1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS14556986
    GO:0005515protein binding IPI12324477
    GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA12324477
         
    Find genes that share ontologies with CD27           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD27:
     Downregulation of NF-kappaB pa  Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd27):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CD27           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd27tm1Jbo for CD27

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD27
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD27
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD27

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD27:
    hsa-mir-335-5p (MIRT017732)

    Block miRNA regulation of human, mouse, rat CD27 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CD27
    SwitchGear 3'UTR luciferase reporter plasmidCD27 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD27
    Predesigned siRNA for gene silencing in human, mouse, rat CD27

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD27

    Clone
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    GenScript: all cDNA clones in your preferred vector: CD27 (NM_001242)
    Sino Biological Human cDNA Clone for CD27
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD27

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD27_HUMAN, P26842: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12624711
    GO:0005887integral component of plasma membrane NAS12324477
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016020membrane ----

    Find genes that share ontologies with CD27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD27 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35


    Find genes that share SuperPaths with CD27           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CD27
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD27 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    CD27 Pathway

    1 GeneGo (Thomson Reuters) Pathway for CD27
        Apoptosis and survival Apoptotic TNF-family pathways

    3 Sino Biological Pathways for CD27
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for CD27):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD27 (see all 9): 
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th1/Th2 Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CD27 (P268421, 3 ENSP000002665574) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIVA1O153041, 3, ENSP000003292134EBI-520729,EBI-520756 I2D: score=5 STRING: ENSP00000329213
    TRAF5O004633, ENSP000002614644I2D: score=3 STRING: ENSP00000261464
    CD70P329703, ENSP000002459034I2D: score=2 STRING: ENSP00000245903
    CD5P061273, ENSP000003426814I2D: score=1 STRING: ENSP00000342681
    UHRF2Q96PU43, ENSP000002768934I2D: score=1 STRING: ENSP00000276893
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway NAS14556986
    GO:0008588release of cytoplasmic sequestered NF-kappaB NAS12324477
    GO:0016064immunoglobulin mediated immune response NAS14556986
    GO:0043066negative regulation of apoptotic process IDA12324477
    GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA12324477

    Find genes that share ontologies with CD27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD27

    1 IUPHAR Ligand for CD27 (CD27)    About this table
    LigandTypeActionAffinityPubmed IDs
    CD70
    NoneNone--

    4 Novoseek inferred chemical compound relationships for CD27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 57.7 1 15708970 (1)
    calcium 4.09 1 1707907 (1)
    serine 0 2 1707907 (1)
    cysteine 0 2 16272303 (1), 1334106 (1)



    Find genes that share compounds with CD27           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD27 gene: 
    NM_001242.4  

    Unigene Cluster for CD27:

    CD27 molecule
    Hs.355307  [show with all ESTs]
    Unigene Representative Sequence: BC012160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266557(uc001qod.3) ENST00000541233
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CD27

    Additional mRNA sequence: 

    AK315732.1 BC012160.1 M63928.1 

    8 DOTS entries:

    DT.112205  DT.121214753  DT.95170259  DT.100704011  DT.100772134  DT.97836572  DT.100778648  DT.97862728 

    4 AceView cDNA sequences:

    CR618820 M63928 BC012160 NM_001242 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACTCTGG
    CD27 Expression
    About this image


    CD27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 4 entries
             T-Cytotoxic Cells Thymus
             Thymus
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Tonsil (Hematopoietic System)
    CD27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355307

    UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
    Tissue specificity: Found in most T-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD27 (see all 9): 
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th1/Th2 Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat CD27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD27 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd271 , 5 CD27 antigen1, 5 76.8(n)1
    67.2(a)1
      6 (59.32 cM)5
    219401  NM_001033126.21  NP_001028298.11 
     1252326225 


    ENSEMBL Gene Tree for CD27 (if available)
    TreeFam Gene Tree for CD27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CD27 (see all 289)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697934
    Lymphoproliferative syndrome 2 (LPFS2)4--see VAR_0697932 C Y mis40--------
    rs37593411,2
    C,F--6483414(+) TACTCA/GGGAGG 1 -- us2k16Minor allele frequency- G:0.42NA WA EA 364
    rs1996464731,2
    C--6483462(+) GTTGC-/AGTGAG 1 -- us2k10--------
    rs1898179401,2
    --6483477(+) GATTGC/TATCAT 1 -- us2k10--------
    rs123027681,2
    C,F,H--6483540(+) AGGAAG/AGTCCC 1 -- us2k1 trp34Minor allele frequency- A:0.06NS WA EA 460
    rs31365501,2
    C,F,A,H--6483544(+) AGGTCC/TCGTCC 1 -- us2k118Minor allele frequency- T:0.25NA NS EA WA 2372
    rs115693511,2
    C,F,H--6483672(+) TTGGCC/TGAGGC 1 -- us2k16Minor allele frequency- T:0.03NS EA WA 688
    rs30872751,2
    H--6483723(+) CCCTGG/AAGAAG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs22865981,2
    C,F,A,H--6483776(-) CCTAAC/GGCTGC 1 -- us2k125Minor allele frequency- G:0.46EA NA NS WA CSA 3349
    rs1397596471,2
    C--6483801(+) CCAGTA/CGGTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD27 (6554033 - 6560884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CD27:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8894CNV Gain18304495
    esv34390CNV Gain17911159
    esv34325CNV Gain17911159
    nsv818881CNV Gain17921354
    essv12131CNV CNV17122850
    nsv442252CNV CNV18776908
    dgv453e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD27
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD27
    DNA2.0 Custom Variant and Variant Library Synthesis for CD27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186711   
    OMIM disorders: 615122  
    UniProtKB/Swiss-Prot: CD27_HUMAN, P26842
  • Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder
    associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T cell-dependent B-cell
    responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low
    hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening
    EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and
    malignant lymphoma requiring stem cell transplantation. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 13 diseases for CD27:    
    About MalaCards
    lymphoproliferative syndrome 2    pars planitis    lymphoproliferative syndrome 1    human immunodeficiency virus infectious disease
    tetanus    plasmacytoma    transverse myelitis    oral lichen planus
    filariasis    pulmonary sarcoidosis    common variable immunodeficiency    myelitis
    interstitial lung disease

    4 diseases from the University of Copenhagen DISEASES database for CD27:
    Common variable immunodeficiency     Lymphoma     Human immunodeficiency virus infectious disease     Systemic lupus erythematosus

    Find genes that share disorders with CD27           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD27 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 57.2 33 9582383 (2), 10809378 (1), 11980654 (1), 17182676 (1) (see all 30)
    lymphoma small lymphocytic 52.4 1 12685844 (1)
    common variable immunodeficiency 44.5 1 16413828 (1)
    leukemia b-cell 43.2 1 7540066 (1)
    leukemia lymphocytic chronic 41.7 3 12685844 (1), 7540066 (1), 10221513 (1)
    lymphoma 39.1 17 12685844 (4), 1940802 (3), 10419648 (3), 9824099 (2) (see all 6)
    lymphocytic leukemia chronic b-cell 39 3 17526459 (2), 7540066 (1)
    lymphoma follicular 38.9 1 12685844 (1)
    tumors 37.2 31 9582383 (2), 9622100 (2), 10809378 (1), 11980654 (1) (see all 27)
    plasmacytoma 33.3 3 12685844 (1), 7540066 (1)

    Genetic Association Database (GAD): CD27
    Human Genome Epidemiology (HuGE) Navigator: CD27 (10 documents)

    Export disorders for CD27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD27 gene, integrated from 10 sources (see all 223):
    (articles sorted by number of sources associating them with CD27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. (PubMed id 1655907)1, 2, 9 Camerini D.... Seed B. (J. Immunol. 1991)
    2. Genomic organization and chromosomal localization of the human CD27 gene. (PubMed id 1334106)1, 2, 9 Loenen W.A....Borst J. (J. Immunol. 1992)
    3. Isolation and regional assignment of human chromosome 12p cDNAs. (PubMed id 8530100)1, 3, 9 Baens M....Marynen P. (Genomics 1995)
    4. Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27. (PubMed id 22801960)1, 2 Salzer E.... Seidel M.G. (Haematologica 2013)
    5. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. (PubMed id 22197273)1, 2 van Montfrans J.M....Tesselaar K. (J. Allergy Clin. Immunol. 2012)
    6. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    7. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. (PubMed id 18774388)1, 4 Tremblay K....Laprise C. (J. Allergy Clin. Immunol. 2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PubMed id 15301860)1, 4 Cho S.M....Lee J.K. (Hum. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 939 HGNC: 11922 AceView: TNFRSF7 Ensembl:ENSG00000139193 euGenes: HUgn939
    ECgene: CD27 Kegg: 939 H-InvDB: CD27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD27 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD27 gene:
    Search GeneIP for patents involving CD27

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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