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Aliases for CD27 Gene

Aliases for CD27 Gene

  • CD27 Molecule 2 3
  • TNFRSF7 3 4 6
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 2 3
  • T-Cell Activation Antigen CD27 3 4
  • CD27L Receptor 3 4
  • CD27 Antigen 3 4
  • S152. LPFS2 3 6
  • T14 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 7 4
  • T Cell Activation Antigen S152 3
  • S152 3
  • Tp55 3

External Ids for CD27 Gene

Previous HGNC Symbols for CD27 Gene


Previous GeneCards Identifiers for CD27 Gene

  • GC12P006554

Summaries for CD27 Gene

Entrez Gene Summary for CD27 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD27 Gene

CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include lymphoproliferative syndrome 2 and autosomal recessive lymphoproliferative disease. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.

UniProtKB/Swiss-Prot for CD27 Gene

  • Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1

Gene Wiki entry for CD27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD27 Gene

Genomics for CD27 Gene

Regulatory Elements for CD27 Gene

Genomic Location for CD27 Gene

6,444,867 bp from pter
6,451,718 bp from pter
6,852 bases
Plus strand

Genomic View for CD27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD27 Gene

Proteins for CD27 Gene

  • Protein details for CD27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD27 antigen
    Protein Accession:
    Secondary Accessions:
    • B2RDZ0

    Protein attributes for CD27 Gene

    260 amino acids
    Molecular mass:
    29137 Da
    Quaternary structure:
    • Homodimer. Interacts with SIVA1 and TRAF2.

neXtProt entry for CD27 Gene

Proteomics data for CD27 Gene at MOPED

Post-translational modifications for CD27 Gene

Other Protein References for CD27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CD27 Gene

Domains for CD27 Gene

Gene Families for CD27 Gene

  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for CD27 Gene

Suggested Antigen Peptide Sequences for CD27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P26842
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with CD27: view

Function for CD27 Gene

Molecular function for CD27 Gene

UniProtKB/Swiss-Prot Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1

Gene Ontology (GO) - Molecular Function for CD27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 14556986
GO:0005515 protein binding IPI 12324477
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 12324477
genes like me logo Genes that share ontologies with CD27: view
genes like me logo Genes that share phenotypes with CD27: view

Animal Models for CD27 Gene

MGI Knock Outs for CD27:

Animal Model Products

CRISPR Products

miRNA for CD27 Gene

miRTarBase miRNAs that target CD27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD27 Gene

Localization for CD27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD27 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD27 Gene COMPARTMENTS Subcellular localization image for CD27 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CD27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12624711
GO:0005887 integral component of plasma membrane NAS 12324477
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CD27: view

Pathways for CD27 Gene

genes like me logo Genes that share pathways with CD27: view

Pathways by source for CD27 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CD27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway NAS 14556986
GO:0008588 release of cytoplasmic sequestered NF-kappaB NAS 12324477
GO:0016064 immunoglobulin mediated immune response NAS 14556986
GO:0043066 negative regulation of apoptotic process IDA 12324477
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 12324477
genes like me logo Genes that share ontologies with CD27: view

Compounds for CD27 Gene

(1) IUPHAR Ligand for CD27 Gene

Ligand Type Action Affinity Pubmed IDs
CD70 None None

(4) Novoseek inferred chemical compound relationships for CD27 Gene

Compound -log(P) Hits PubMed IDs
bcma 57.7 1
calcium 4.09 1
serine 0 1
cysteine 0 2
genes like me logo Genes that share compounds with CD27: view

Transcripts for CD27 Gene

mRNA/cDNA for CD27 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD27 Gene

CD27 molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD27 Gene

No ASD Table

Relevant External Links for CD27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD27 Gene

mRNA expression in normal human tissues for CD27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD27 Gene

This gene is overexpressed in Spleen (9.2), Whole Blood (7.4), and Small Intestine - Terminal Ileum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD27 Gene

SOURCE GeneReport for Unigene cluster for CD27 Gene Hs.355307

mRNA Expression by UniProt/SwissProt for CD27 Gene

Tissue specificity: Found in most T-lymphocytes
genes like me logo Genes that share expressions with CD27: view

In Situ Assay Products

Orthologs for CD27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD27 35
  • 99.49 (n)
  • 100 (a)
CD27 36
  • 100 (a)
(Bos Taurus)
Mammalia CD27 35
  • 81.5 (n)
  • 75.92 (a)
CD27 36
  • 75 (a)
(Canis familiaris)
Mammalia CD27 35
  • 83.01 (n)
  • 75.1 (a)
CD27 36
  • 73 (a)
(Mus musculus)
Mammalia Cd27 35
  • 76.8 (n)
  • 67.2 (a)
Cd27 16
Cd27 36
  • 67 (a)
(Monodelphis domestica)
Mammalia CD27 36
  • 41 (a)
(Rattus norvegicus)
Mammalia Cd27 35
  • 76.93 (n)
  • 68.8 (a)
Species with no ortholog for CD27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD27 Gene

Gene Tree for CD27 (if available)
Gene Tree for CD27 (if available)

Paralogs for CD27 Gene

No data available for Paralogs for CD27 Gene

Variants for CD27 Gene

Sequence variations from dbSNP and Humsavar for CD27 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2532508 -- 6,443,669(-) CACAT(C/T)TGGGT upstream-variant-2KB
rs2532509 -- 6,443,631(-) CCAGC(C/T)TTGTC upstream-variant-2KB
rs2532510 -- 6,443,585(-) GAGTG(C/T)TGTGG upstream-variant-2KB
rs2532511 -- 6,443,577(-) TGGCC(C/G)TGAGG upstream-variant-2KB
VAR_016148 -

Structural Variations from Database of Genomic Variants (DGV) for CD27 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv818881 CNV Gain 17921354
nsv442252 CNV CNV 18776908
nsv8894 CNV Gain 18304495

Relevant External Links for CD27 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD27 Gene

Disorders for CD27 Gene

(1) OMIM Diseases for CD27 Gene (186711)


  • Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation. {ECO:0000269 PubMed:22197273, ECO:0000269 PubMed:22801960}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(26) Novoseek inferred disease relationships for CD27 Gene

Disease -log(P) Hits PubMed IDs
necrosis 57.2 31
lymphoma small lymphocytic 52.4 1
common variable immunodeficiency 44.5 1
leukemia b-cell 43.2 1
leukemia lymphocytic chronic 41.7 3

Relevant External Links for CD27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD27: view

Publications for CD27 Gene

  1. Genomic organization and chromosomal localization of the human CD27 gene. (PMID: 1334106) Loenen W.A. … Borst J. (J. Immunol. 1992) 3 4 23
  2. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. (PMID: 1655907) Camerini D. … Seed B. (J. Immunol. 1991) 3 4 23
  3. Isolation and regional assignment of human chromosome 12p cDNAs. (PMID: 8530100) Baens M. … Marynen P. (Genomics 1995) 2 3 23
  4. CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells. (PMID: 9862673) Nagumo H. … Komiyama A. (J. Immunol. 1998) 3 23
  5. CD27-CD70 interactions regulate B-cell activation by T cells. (PMID: 7479974) Kobata T. … Morimoto C. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23

Products for CD27 Gene

Sources for CD27 Gene

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