CD27 Gene

Aliases
for CD27 gene

Previous GC identifer: GC12P006425

Summaries
for CD27 gene

Genomic Views
for CD27 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_009759.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD27 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD27

CD27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006554:  view genomic region     (about GC identifiers)

Proteins
for CD27 gene

Explore the universe of human proteins at neXtProt for CD27: NX_P26842

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD27 (CD27/TNFRSF7)
	Enzo Life Sciences proteins for CD27
	OriGene Purified Protein: CD27 OriGene Protein Over-expression Lysate: CD27 OriGene Custom Protein Services for CD27
	GenScript Custom Purified and Recombinant Proteins Services for CD27
	Novus Biologicals CD27 Proteins Novus Biologicals CD27 Lysates
	Sino Biological Recombinant Protein for CD27
	ProSpec Recombinant Protein for CD27
	Uscn Proteins for CD27

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD27
	R&D Systems Antibodies for CD27 (CD27/TNFRSF7)
	OriGene Antibodies (see all 2): CD27 OriGene Custom Antibody Services for CD27
	GenScript Custom Superior Antibodies Services for CD27
	Novus Biologicals CD27 Antibodies
	Abcam antibodies for CD27
	Uscn Antibodies for CD27
	ThermoFisher Antibody for CD27

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD27 (CD27/TNFRSF7)
	GenScript Custom Assay Services for CD27
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD27

Protein Domains /
Families
for CD27 gene

ProtoNet protein and cluster: P26842

Function
for CD27 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD27
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD27
		SwitchGear 3'UTR luciferase reporter plasmid: CD27 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD27 (see all 7) OriGene shRNA RFP: CD27 OriGene siRNA: CD27
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD27

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD27

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD27 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD27 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD27 (NM_001242)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD27
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD27

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD27
		Search LifeMap BioReagents cell lines for CD27

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cd27)

Pathways & Interactions
for CD27 gene

	Super-pathway	contained gene-specific pathways
1	Apoptosis and survival_Apoptotic TNF-family pathways	Apoptosis and survival_Apoptotic TNF-family pathways 1.00 Apoptosis and survival Apoptotic TNF-family pathways 1.00
2	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.26
3	TRAF Pathway	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions 0.08

1 EMD Millipore Pathway for CD27

Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for CD27

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

1 GeneGo (Thomson Reuters) Pathway for CD27

Apoptosis and survival Apoptotic TNF-family pathways

1         Kegg Pathway  (Kegg details for CD27)

Cytokine-cytokine receptor interaction

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for CD27 gene

Transcripts
for CD27 gene

Expression
for CD27 gene

CD27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGACTCTGG

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BloodPeripheral BloodT-Cytotoxic Cells			Blood
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD27 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD27
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD27
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD27

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD27

Orthologs
for CD27 gene

Paralogs
for CD27 gene

Genomic Variants
for CD27 gene

10/236 NCBI SNPs in CD27 are shown (see all 236)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs115693511,2	C,F,H,	--	6406601(+)	TTGGCC/TGAGGC	2	--	us2k1 int1		6		NS EA WA	688
rs30872751,2	H	--	6406652(+)	CCCTGG/AAGAAG	2	--	us2k1 int1		4		NS EA	418
rs609822241,2	C,	--	6406805(+)	TTCCTC/TATGAT	2	--	us2k1 int1		2		WA	120
rs1125750761,2		--	6406950(+)	CTCTGC/TGGTGG	2	--	us2k1 nc-transcript-variant		1		CSA	2
rs115693561,2	C,	--	6407387(+)	CCCGTA/TGGAAG	2	--	us2k1 int1		1		NS	180
rs1128459071,2		--	6407453(+)	GGACAA/CCAGTG	2	--	us2k1 int1		1		CSA	1
rs115693571,2	C,F,H,	--	6407525(+)	AAGGGT/CCTGAG	2	--	us2k1 int1		18		NS EA NA	2042
rs115693581,2	C,F,H,	--	6407693(+)	TCAAAC/TCAGAC	2	--	us2k1 int1		17		NS EA NA	1810
rs115693621,2	F	--	6408008(+)	TGGACG/TGGGGG	2	--	us2k1 int1		1		NS	176
rs128217431,2	H	--	6408035(+)	AACGTG/TGGCAC	2	--	us2k1 int1		4		NS EA	418

HapMap Linkage Disequilibrium report for CD27 (6554033 - 6560884 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CD27
     7 CNVs: 3872 8706 2967 9679 30577 8705 37679
Human Gene Mutation Database (HGMD): CD27

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD27

DNA2.0 Custom Variant and Variant Library Synthesis for CD27

Disorders / Diseases
for CD27 gene

20/59 diseases for CD27

10/26 Novoseek disease relationships for CD27 gene (see all 26)    About this table

Publications
for CD27 gene

PubMed articles for CD27 gene, integrated from 9 sources (see all 213): (articles sorted by number of sources associating them with CD27)

Utopia: connect your pdf to the dynamic world of online information

1. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. (PubMed id 1655907)^{1, 2, 9} Camerini D.... Seed B. (1991)
2. Genomic organization and chromosomal localization of the human CD27 gene. (PubMed id 1334106)^{1, 2, 9} Loenen W.A....Borst J. (1992)
3. Isolation and regional assignment of human chromosome 12p cDNAs. (PubMed id 8530100)^{1, 3, 9} Baens M....Marynen P. (1995)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. (PubMed id 9692890)^{1, 2} Gravestein L.A....Borst J. (1998)
8. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. (PubMed id 9177220)^{1, 2} Prasad K.V.S....Schlossman S.F. (1997)
9. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. (PubMed id 2442250)^{1, 3} van Lier R.A....Melief C.J. (1987)
10. CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naive B cells. (PubMed id 12685844)^{1, 9} Dong H.Y....Dorfman D.M. (2002)

External Searches for CD27 gene

Genome Databases showing CD27 gene

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Specialized Databases showing CD27 gene

Products
for CD27 gene