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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD248 Gene

protein-coding   GIFtS: 52
GCID: GC11M066083

CD248 molecule, endosialin

(Previous names: CD164 sialomucin-like 1, CD248 antigen, endosialin )
(Previous symbol: CD164L1)
 Explore 9 diseases affiliated with
CD248 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD248    

Aliases
for CD248 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD248 Molecule, Endosialin1 2     Tumor Endothelial Marker 12 3
TEM11 2 3 5     2610111G01Rik2
CD164L11 2 3     Endosialin1
CD164 Sialomucin-Like 11 2     CD248 Antigen3
CD248 Antigen, Endosialin1 2     

External Ids:    HGNC: 182191   Entrez Gene: 571242   Ensembl: ENSG000001748077   OMIM: 6060645   UniProtKB: Q9HCU03   

Export aliases for CD248 gene to outside databases

Previous GC identifers: GC11M065839 GC11M062435


Summaries
for CD248 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
Function: May play a role in tumor angiogenesis

Gene Wiki entry for CD248


Genomic Views
for CD248 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD248 gene promoter:
         AhR   SREBP-1c   Pax-6   AP-4   CUTL1   SREBP-1b   GATA-2   RORalpha1   SREBP-1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD248 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD248

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD248


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

CD248 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD248 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066083:  view genomic region     (about GC identifiers)

Start:
 66,081,958 bp from pter      End:
 66,084,515 bp from pter
Size:
 2,558 bases      Orientation:
 minus strand

Proteins
for CD248 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0 (See protein sequence)
Recommended Name: Endosialin precursor  
Size: 757 amino acids; 80859 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Secondary accessions: Q2M2V5 Q3SX55 Q96KB6
Alternative splicing: 2 isoforms:  Q9HCU0-1   Q9HCU0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD248: NX_Q9HCU0

Post-translational modifications:

  • O-glycosylated with sialylated oligosaccharides1
  • May be N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HCU0

    • CD248 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065137.1  
    ENSEMBL proteins: 
     ENSP00000308117  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: CD248
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    Novus Biologicals CD248 Proteins
    Novus Biologicals CD248 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD248

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS10947988
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IEA--


    CD248 for ontologies           About GeneDecksing



    CD248 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD248
    R&D Systems Antibodies for CD248 (Endosialin/CD248)
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    Abcam antibodies for CD248 
    Uscn Antibodies for CD248
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    Assay Products for CD248: 
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    Uscn ELISAs and CLIAs for CD248

    Protein Domains /
    Families
    for CD248 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD248 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR016187 C-type_lectin_fold
     IPR001881 EGF-like_Ca-bd

    Graphical View of Domain Structure for InterPro Entry Q9HCU0

    ProtoNet protein and cluster: Q9HCU0

    2 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    Function
    for CD248 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
    Function: May play a role in tumor angiogenesis

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD248
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CD248 (see all 17):
    hsa-miR-125a-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-3667-5p hsa-miR-125b hsa-miR-198 hsa-miR-3065-3p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmid: CD248 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD248 (see all 7)
    OriGene shRNA RFP: CD248
    OriGene siRNA: CD248
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD248

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD248

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD248 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD248 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD248
    Search LifeMap BioReagents cell lines for CD248

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD248

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005509calcium ion binding IEA--
    GO:0030246carbohydrate binding IEA--


    CD248 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CD248:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Cd248tm1Huso for CD248
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd248):
     immune system  normal  tumorigenesis 

    CD248 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD248 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD248

    1 Interacting protein for CD248 (Q9HCU03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS3BPQ083803I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    CD248 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD248 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD248
    Search CenterWatch for drugs/clinical trials and news about CD248 

    Transcripts
    for CD248 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD248 gene: 
    NM_020404.2  

    Unigene Cluster for CD248:

    CD248 molecule, endosialin
    Hs.195727  [show with all ESTs]
    Unigene Representative Sequence: BC051340
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311330(uc001ohm.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CD248
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD248
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CD248 (see all 17):
    hsa-miR-125a-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-3667-5p hsa-miR-125b hsa-miR-198 hsa-miR-3065-3p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmid: CD248 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD248 (see all 7)
    OriGene shRNA RFP: CD248
    OriGene siRNA: CD248
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD248
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD248 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD248
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD248
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD248

    Additional cDNA sequence: 

    AF279142.1 AJ295846.1 AK027290.1 BC051340.1 BC098158.1 BC104484.1 BC105633.1 

    4 DOTS entries:

    DT.444033  DT.91743374  DT.91743376  DT.100717940 

    24/107 AceView cDNA sequences (see all 107):

    AK027290 BX095146 AF279142 BU617742 BX356251 AI783755 BM930348 AA430355 
    AI968594 BC051340 AI656074 CR613070 NM_020404 AW516908 BM918453 CR591995 
    T55811 BQ005949 AI371224 AJ295846 AW166405 BM855904 AW572281 BX333450 

    GeneLoc Exon Structure


    Expression
    for CD248 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD248 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGCTGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD248 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneStylopod Long BoneBone
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    HeartAtrioventricular CanalHeart
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cartilage-like cells (Differentiation of s...)Cartilage

    See CD248 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD248

    SOURCE GeneReport for Unigene cluster: Hs.195727

    UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
    Tissue specificity: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells.
    Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing.
    Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal
    fibroblasts

        SABiosciences Custom PCR Arrays for CD248
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD248

    Orthologs
    for CD248 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CD248 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CD2486
    		 --
    		 49(a)
    		 1 ↔ 1
    		 AAWZ02038895(7974-9245)
    zebrafish
    (Danio rerio)    		 Actinopterygii cd248b6
    cd248a6
    		 CD248 molecule, endosialin a
    		 30(a)
    27(a)
    		 1 ↔ many
    1 ↔ many
    		 21(25887181-25889187)
    7(19379597-19382593)
    worm
    (Caenorhabditis elegans)    		 Secernentea fbn-16
    		 FiBrilliN homolog family member (fbn-1)
    		 5(a)
    		 1 → many
    		 III(7625311-7640988)


    ENSEMBL Gene Tree for CD248 (if available)
    TreeFam Gene Tree for CD248 (if available) 

    Paralogs
    for CD248 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD248 gene
    CLEC14A2  THBD2  CD932  

    CD248 for paralogs           About GeneDecksing



    Genomic Variants
    for CD248 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 NCBI SNPs in CD248 are shown (see all 117)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1920230351,2
    		--66081721(+) AATAAA/GGAATA 1 -- int10--------
    rs1123504021,2
    		--66081979(+) CACCCC/TATTTA 1 -- ut310--------
    rs1151525741,2
    		C,F,--66082000(+) CCCCAG/ACACCC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1884957161,2
    		--66082050(+) ACGAGC/TGCTGG 1 -- ut310--------
    rs1123298831,2
    		C,--66082055(+) CGCTGG/AGCCAG 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs799936211,2
    		C,--66082125(+) GGAGCA/GGGAAG 1 -- ut312Minor allele frequency- G:0.10WA 120
    rs1139942161,2
    		C,F,--66082182(+) GGCCAT/AGTGTC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs797644621,2
    		C,--66082213(+) GGGGGG/ATCTGC 1 -- ut312Minor allele frequency- A:0.12WA 120
    rs1825475591,2
    		C,--66082215(+) GGGGTC/GTGCAC 1 -- ut310--------
    rs1444932831,2
    		--66082324(+) CGATAA/GCAGTC 2 C syn10--------

    HapMap Linkage Disequilibrium report for CD248 (66081958 - 66084515 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD248: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CD248 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD248 for disorders           About GeneDecksing

    OMIM gene information: 606064    OMIM disorders: --

    9 diseases for CD248:    About MalaCards
    gastroenteritis    shigellosis    kidney disease    skin cancer
    diarrhea    meningitis    sarcoma    hypoxia
    carcinoma

    5 Novoseek disease relationships for CD248 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 76.1 3 19212666 (1), 19948061 (1)
    blood vessel tumors 75.5 3 16531767 (1), 16420310 (1), 11084048 (1)
    sarcoma 41.5 7 16076089 (2), 20477527 (2), 19010839 (2)
    tumors 40.1 73 15624764 (5), 18187565 (5), 18490383 (4), 19948061 (4) (see all 18)
    cancer 34 20 16875435 (5), 16076089 (2), 19010839 (2), 20477527 (2) (see all 9)

    Human Genome Epidemiology (HuGE) Navigator: CD248 (1 document)

    Export disorders for CD248 gene to outside databases

    Publications
    for CD248 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD248 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CD248)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. (PubMed id 11084048)1, 2, 3, 9 Christian S....Lenter M.C. (2001)
    2. Genes expressed in human tumor endothelium. (PubMed id 10947988)1, 2, 3 St Croix B....Kinzler K.W. (2000)
    3. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. (PubMed id 15862292)1, 2, 9 MacFadyen J.R.... Isacke C.M. (2005)
    4. Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. (PubMed id 16076089)1, 2, 9 Dolznig H.... Garin-Chesa P. (2005)
    5. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. (PubMed id 1438285)1, 2, 9 Rettig W.J....Old L.J. (1992)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of TEM1/endosialin in human and muri ne brain tumors. (PubMed id 19948061)1, 9 Carson-Walter E.B....Walter K.A. (2009)
    9. Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. (PubMed id 18187565)1, 9 Christian S....Augustin H.G. (2008)
    10. Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K. (PubMed id 18490383)1, 9 Becker R....Christian S. (2008)

    External Searches for CD248 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CD248 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57124 HGNC: 18219 AceView: CD164L1 Ensembl:ENSG00000174807 euGenes: HUgn57124
    ECgene: CD248 H-InvDB: CD248

    Other Databases showing CD248 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD248 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD248 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD248 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_210

    Intellectual Property
    for CD248 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD248 gene:
    Search GeneIP for patents involving CD248

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of CD248
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     Regulatory tfbs in CD248 promoter
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     CD248 Proteins, Antibodies, CLIAs, and ELISAs
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