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CD248 Gene

protein-coding   GIFtS: 54
GCID: GC11M066083

CD248 Molecule, Endosialin

(Previous names: CD164 sialomucin-like 1, CD248 antigen, endosialin)
(Previous symbol: CD164L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD248 Molecule, Endosialin1 2     CD248 Antigen, Endosialin1 2
CD164L11 2 3     endosialin1 2
Tumor Endothelial Marker 11 2 3     2610111G01Rik2
TEM12 3 5     CD248 Antigen3
CD164 Sialomucin-Like 11 2     

External Ids:    HGNC: 182191   Entrez Gene: 571242   Ensembl: ENSG000001748077   OMIM: 6060645   UniProtKB: Q9HCU03   

Export aliases for CD248 gene to outside databases

Previous GC identifers: GC11M065839 GC11M062435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD248 Gene:
CD248 (CD248 molecule, endosialin) is a protein-coding gene. Diseases associated with CD248 include shigellosis, and gastroenteritis. GO annotations related to this gene include extracellular matrix binding and calcium ion binding. An important paralog of this gene is CLEC14A.

UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
Function: May play a role in tumor angiogenesis

Gene Wiki entry for CD248 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD248 gene promoter:
         AhR   SREBP-1c   Pax-6   AP-4   CUTL1   SREBP-1b   GATA-2   RORalpha1   SREBP-1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD248 promoter sequence
   Search Chromatin IP Primers for CD248

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD248


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

CD248 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD248 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066083:  view genomic region     (about GC identifiers)

Start:
66,081,958 bp from pter      End:
66,084,515 bp from pter
Size:
2,558 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0 (See protein sequence)
Recommended Name: Endosialin precursor  
Size: 757 amino acids; 80859 Da
Secondary accessions: Q2M2V5 Q3SX55 Q96KB6
Alternative splicing: 2 isoforms:  Q9HCU0-1   Q9HCU0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD248: NX_Q9HCU0

Explore proteomics data for CD248 at MOPED

Post-translational modifications: 

  • O-glycosylated with sialylated oligosaccharides1
  • May be N-glycosylated1
  • Glycosylation2 at Thr60, Thr401, Thr428, Thr448, Thr456, Thr459, Thr472, Thr519, Thr541, Thr543,
                                 Thr544, Thr545, Thr587, Thr593, Thr594, Thr595, Ser598, Ser601, Thr612, Thr619 (see all 27)
  • Modification sites at PhosphoSitePlus

  • See CD248 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065137.1  
    ENSEMBL proteins: 
     ENSP00000308117  

    CD248 Human Recombinant Protein Products:

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    Novus Biologicals CD248 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD248 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD248
    R&D Systems Antibodies for CD248 (Endosialin/CD248)
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    Novus Biologicals CD248 Antibodies
    Abcam antibodies for CD248
    Browse Antibodies at Cloud-Clone Corp.
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    LSBio Antibodies in human, mouse, rat for CD248

    CD248 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR016187 C-type_lectin_fold
     IPR001881 EGF-like_Ca-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCU0

    ProtoNet protein and cluster: Q9HCU0

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    CD248 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD248_HUMAN, Q9HCU0
    Function: May play a role in tumor angiogenesis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
    GO:0050840extracellular matrix binding IEA--
         
    CD248 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CD248:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd248):
     immune system  normal  tumorigenesis 

    CD248 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd248tm1Huso for CD248

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD248
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD248

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD248
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD248

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD248:
    hsa-mir-26b-5p (MIRT029660)

    Block miRNA regulation of human, mouse, rat CD248 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD248 (see all 17):
    hsa-miR-125a-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-3667-5p hsa-miR-125b hsa-miR-198 hsa-miR-3065-3p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD248 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD248
    Predesigned siRNA for gene silencing in human, mouse, rat CD248

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CD248 (NM_020404)
    Sino Biological Human cDNA Clone for CD248
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD248

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD248


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD248_HUMAN, Q9HCU0: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    peroxisome2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix TAS10947988
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--

    CD248 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD248
    Interactions:

        Search GeneGlobe Interaction Network for CD248

    1 Interacting protein for CD248 (Q9HCU03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS3BPQ083803I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0016477cell migration IEA--
    GO:0048535lymph node development IEA--
    GO:0060033anatomical structure regression IEA--

    CD248 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD248



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD248 gene: 
    NM_020404.2  

    Unigene Cluster for CD248:

    CD248 molecule, endosialin
    Hs.195727  [show with all ESTs]
    Unigene Representative Sequence: BC051340
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311330(uc001ohm.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD248 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD248 (see all 17):
    hsa-miR-125a-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-3667-5p hsa-miR-125b hsa-miR-198 hsa-miR-3065-3p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD248 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD248
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    GenScript: all cDNA clones in your preferred vector: CD248 (NM_020404)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD248
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD248
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD248
    OriGene qSTAR qPCR primer pairs in human, mouse for CD248
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD248
      QuantiTect SYBR Green Assays in human, mouse, rat CD248
      QuantiFast Probe-based Assays in human, mouse, rat CD248

    Additional mRNA sequence: 

    AF279142.1 AJ295846.1 AK027290.1 BC051340.1 BC098158.1 BC104484.1 BC105633.1 

    4 DOTS entries:

    DT.444033  DT.91743374  DT.91743376  DT.100717940 

    Selected AceView cDNA sequences (see all 107):

    AI783755 BX095146 AF279142 CR613070 T55811 BX356251 BM918453 BU617742 
    AW516908 BM930348 NM_020404 AK027290 AI968594 AI656074 AI371224 AJ295846 
    AW166405 BQ005949 CR591995 BC051340 AA430355 BX399915 AI652283 AJ573322 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD248 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCTGCCC
    CD248 Expression
    About this image


    CD248 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Long Bone
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             S-shaped Body
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    CD248 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD248 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195727

    UniProtKB/Swiss-Prot: CD248_HUMAN, Q9HCU0
    Tissue specificity: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial
    cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound
    healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed
    in stromal fibroblasts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD248

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD248 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2481 , 5 CD248 antigen, endosialin1, 5 82.27(n)1
    80(a)1
      19 (4.24 cM)5
    704451  NM_054042.21  NP_473383.11 
     50680785 
    lizard
    (Anolis carolinensis)
    Reptilia CD2486
    CD248 molecule, endosialin
    46(a)
    1 ↔ 1
    AAWZ02038895(7974-9245)
    zebrafish
    (Danio rerio)
    Actinopterygii cd248b6
    cd248a6
    CD248 molecule, endosialin a
    29(a)
    26(a)
    1 ↔ many
    1 ↔ many
    21(25887181-25889187) ENSDARG00000077938
    7(19379597-19382593) ENSDARG00000079898


    ENSEMBL Gene Tree for CD248 (if available)
    TreeFam Gene Tree for CD248 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD248 gene
    CLEC14A2  THBD2  CD932  

    CD248 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD248 (see all 176)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363994
    A colorectal cancer sample4--see VAR_0363992 L F mis40--------
    rs1920230351,2
    --66081721(+) AATAAA/GGAATA 1 -- int10--------
    rs1123504021,2
    C--66081979(+) CACCCC/TATTTA 1 -- ut310--------
    rs1151525741,2
    C,F--66082000(+) CCCCAG/ACACCC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1884957161,2
    --66082050(+) ACGAGC/TGCTGG 1 -- ut310--------
    rs1123298831,2
    C--66082055(+) CGCTGG/AGCCAG 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs799936211,2
    C,F--66082125(+) GGAGCA/GGGAAG 1 -- ut312Minor allele frequency- G:0.10WA 120
    rs1139942161,2
    C,F--66082182(+) GGCCAT/AGTGTC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs797644621,2
    C--66082213(+) GGGGGG/ATCTGC 1 -- ut312Minor allele frequency- A:0.12WA 120
    rs1825475591,2
    C--66082215(+) GGGGTC/GTGCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD248 (66081958 - 66084515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD248:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD248
    DNA2.0 Custom Variant and Variant Library Synthesis for CD248

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606064    OMIM disorders: --

    12 diseases for CD248:    
    About MalaCards
    shigellosis    gastroenteritis    endotheliitis    breast and colorectal cancer
    diarrhea    hypoxia    meningitis    kidney disease
    sarcoma    bipolar disorder    cerebritis    colorectal cancer


    CD248 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CD248 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 76.1 3 19212666 (1), 19948061 (1)
    blood vessel tumors 75.5 3 16531767 (1), 16420310 (1), 11084048 (1)
    sarcoma 41.5 7 16076089 (2), 20477527 (2), 19010839 (2)
    tumors 40.1 73 15624764 (5), 18187565 (5), 18490383 (4), 19948061 (4) (see all 18)
    cancer 34 20 16875435 (5), 16076089 (2), 19010839 (2), 20477527 (2) (see all 9)

    Genetic Association Database (GAD): CD248
    Human Genome Epidemiology (HuGE) Navigator: CD248 (1 document)

    Export disorders for CD248 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD248 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CD248)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. (PubMed id 11084048)1, 2, 3, 9 Christian S.... Lenter M.C. (J. Biol. Chem. 2001)
    2. Genes expressed in human tumor endothelium. (PubMed id 10947988)1, 2, 3 St Croix B....Kinzler K.W. (Science 2000)
    3. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. (PubMed id 15862292)1, 2, 9 MacFadyen J.R.... Isacke C.M. (FEBS Lett. 2005)
    4. Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin. (PubMed id 16076089)1, 2, 9 Dolznig H.... Garin-Chesa P. (Cancer Immun. 2005)
    5. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. (PubMed id 1438285)1, 2, 9 Rettig W.J....Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of TEM1/endosialin in human and murine brain tumors. (PubMed id 19948061)1, 9 Carson-Walter E.B....Walter K.A. (BMC Cancer 2009)
    9. Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. (PubMed id 18187565)1, 9 Christian S....Augustin H.G. (Am. J. Pathol. 2008)
    10. Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K. (PubMed id 18490383)1, 9 Becker R....Christian S. (FASEB J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57124 HGNC: 18219 AceView: CD164L1 Ensembl:ENSG00000174807 euGenes: HUgn57124
    ECgene: CD248 H-InvDB: CD248

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD248 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD248 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_210

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD248 gene:
    Search GeneIP for patents involving CD248

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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