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Aliases for CD247 Gene

Aliases for CD247 Gene

  • CD247 Molecule 2 3
  • CD3Z 3 4 6
  • TCRZ 3 4 6
  • CD3z Antigen, Zeta Polypeptide (TiT3 Complex) 2 3
  • T-Cell Receptor T3 Zeta Chain 3 4
  • CD247 Antigen 2 4
  • T3Z 3 4
  • T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3 3
  • T-Cell Surface Glycoprotein CD3 Zeta Chain 3
  • CD247 Antigen, Zeta Subunit 3
  • TCR Zeta Chain 3
  • CD3zeta Chain 3
  • CD3-ZETA 3
  • IMD25 3
  • CD3H 3
  • CD3Q 3

External Ids for CD247 Gene

Previous HGNC Symbols for CD247 Gene

  • CD3Z

Previous GeneCards Identifiers for CD247 Gene

  • GC01M165666
  • GC01M138645

Summaries for CD247 Gene

Entrez Gene Summary for CD247 Gene

  • The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD247 Gene

CD247 (CD247 Molecule) is a Protein Coding gene. Diseases associated with CD247 include immunodeficiency 25 and polyarticular onset juvenile idiopathic arthritis. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein homodimerization activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for CD247 Gene

  • Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering

Gene Wiki entry for CD247 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD247 Gene

Genomics for CD247 Gene

Regulatory Elements for CD247 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD247 Gene

167,430,640 bp from pter
167,518,610 bp from pter
87,971 bases
Minus strand

Genomic View for CD247 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD247 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD247 Gene

Proteins for CD247 Gene

  • Protein details for CD247 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD3 zeta chain
    Protein Accession:
    Secondary Accessions:
    • B1AK49
    • Q5VX13
    • Q8TAX4

    Protein attributes for CD247 Gene

    164 amino acids
    Molecular mass:
    18696 Da
    Quaternary structure:
    • The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up-regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC.

    Three dimensional structures from OCA and Proteopedia for CD247 Gene

    Alternative splice isoforms for CD247 Gene


neXtProt entry for CD247 Gene

Proteomics data for CD247 Gene at MOPED

Post-translational modifications for CD247 Gene

  • Phosphorylated on Tyr residues after T-cell receptor triggering.
  • Ubiquitination at Lys88, Lys99, Lys104, Lys118, Lys129, Lys136, and Lys150
  • Modification sites at PhosphoSitePlus

Other Protein References for CD247 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD247 Gene

Domains for CD247 Gene

Gene Families for CD247 Gene

  • CD :CD molecules

Suggested Antigen Peptide Sequences for CD247 Gene

Graphical View of Domain Structure for InterPro Entry



  • P20963
  • The ITAM domains mediate interaction with SHB
  • Contains 3 ITAM domains.
  • Belongs to the CD3Z/FCER1G family.
genes like me logo Genes that share domains with CD247: view

Function for CD247 Gene

Molecular function for CD247 Gene

UniProtKB/Swiss-Prot Function:
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering

Gene Ontology (GO) - Molecular Function for CD247 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 10704231
GO:0042802 identical protein binding IPI 17055436
GO:0042803 protein homodimerization activity NAS 12110186
genes like me logo Genes that share ontologies with CD247: view
genes like me logo Genes that share phenotypes with CD247: view

Animal Models for CD247 Gene

MGI Knock Outs for CD247:

Animal Model Products

miRNA for CD247 Gene

miRTarBase miRNAs that target CD247

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD247

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD247 Gene

Localization for CD247 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD247 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD247 Gene COMPARTMENTS Subcellular localization image for CD247 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD247 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11390434
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0042101 T cell receptor complex IDA 8176201
genes like me logo Genes that share ontologies with CD247: view

Pathways for CD247 Gene

genes like me logo Genes that share pathways with CD247: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD247 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0016032 viral process TAS --
GO:0031295 T cell costimulation TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CD247: view

Compounds for CD247 Gene

(1) Drugbank Compounds for CD247 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • AntiCD3
140608-64-6 target

(10) Novoseek inferred chemical compound relationships for CD247 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 64.7 52
gdp 25 5
calcium 18.4 8
phosphatidylinositol 11.9 1
arginine 10.2 13
genes like me logo Genes that share compounds with CD247: view

Transcripts for CD247 Gene

Unigene Clusters for CD247 Gene

CD247 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD247

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD247 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: -
SP6: - - - - - -
SP7: - -
SP8: - -
SP9: - - -

Relevant External Links for CD247 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD247 Gene

mRNA expression in normal human tissues for CD247 Gene

mRNA differential expression in normal tissues according to GTEx for CD247 Gene

This gene is overexpressed in Whole Blood (30.8) and Spleen (5.7).

Protein differential expression in normal tissues for CD247 Gene

This gene is overexpressed in NK cells (27.9), Peripheral blood mononuclear cells (22.0), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD247 Gene

SOURCE GeneReport for Unigene cluster for CD247 Gene Hs.156445

genes like me logo Genes that share expressions with CD247: view

Expression partners for CD247 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD247 Gene

Orthologs for CD247 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD247 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD247 35
  • 83.33 (n)
  • 84.76 (a)
CD247 36
  • 84 (a)
(Canis familiaris)
Mammalia CD247 35
  • 85.96 (n)
  • 84.21 (a)
CD247 36
  • 78 (a)
(Mus musculus)
Mammalia Cd247 35
  • 81.71 (n)
  • 81.1 (a)
Cd247 16
Cd247 36
  • 58 (a)
(Pan troglodytes)
Mammalia CD247 35
  • 99.59 (n)
  • 100 (a)
CD247 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cd247 35
  • 83.94 (n)
  • 85.37 (a)
(Monodelphis domestica)
Mammalia CD247 36
  • 78 (a)
(Gallus gallus)
Aves CD247 35
  • 69.12 (n)
  • 63.19 (a)
CD247 36
  • 60 (a)
(Anolis carolinensis)
Reptilia CD247 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd247 35
  • 56.28 (n)
  • 49.35 (a)
(Danio rerio)
Actinopterygii cd247l 36
  • 28 (a)
Species with no ortholog for CD247:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD247 Gene

Gene Tree for CD247 (if available)
Gene Tree for CD247 (if available)

Paralogs for CD247 Gene

Selected SIMAP similar genes for CD247 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD247: view

No data available for Paralogs for CD247 Gene

Variants for CD247 Gene

Sequence variations from dbSNP and Humsavar for CD247 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs704848 -- 167,492,636(-) CTAAT(C/G)GGGGC intron-variant
rs704849 -- 167,493,067(-) acact(C/G)catct intron-variant
rs704850 -- 167,493,468(-) acagt(A/G)ctcaG intron-variant
rs704851 -- 167,493,823(-) TTAAA(C/T)AAGAA intron-variant
rs704852 -- 167,494,679(-) TTTGA(G/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD247 Gene

Variant ID Type Subtype PubMed ID
nsv831814 CNV Loss 17160897
nsv872524 CNV Gain 21882294
nsv3432 CNV Insertion 18451855
esv998064 CNV Deletion 20482838
esv1365494 CNV Deletion 17803354
esv2719206 CNV Deletion 23290073
nsv528248 CNV Loss 19592680
nsv528710 CNV Gain 19592680
nsv528380 CNV Loss 19592680
esv2665370 CNV Deletion 23128226

Relevant External Links for CD247 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD247 Gene

Disorders for CD247 Gene

(1) OMIM Diseases for CD247 Gene (186780)


  • Immunodeficiency 25 (IMD25) [MIM:610163]: An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. {ECO:0000269 PubMed:16672702}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CD247 Gene

(24) Novoseek inferred disease relationships for CD247 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 56.9 13
tumors 28.2 19
metastatic melanoma 26.4 1
ovarian carcinoma 24 3
cancer 24 13

Relevant External Links for CD247

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD247: view

No data available for Genatlas for CD247 Gene

Publications for CD247 Gene

  1. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. (PMID: 16672702) Rieux-Laucat F. … Le Deist F. (N. Engl. J. Med. 2006) 3 4 23
  2. Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex. (PMID: 2974162) Weissman A.M. … Klausner R.D. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4
  3. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. (PMID: 9484780) Welsh M. … Shoelson S.E. (Oncogene 1998) 3 4
  4. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. (PMID: 7680960) Waksman G. … Kuriyan J. (Cell 1993) 3 4
  5. Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment. (PMID: 17054067) Zea A.H. … Ochoa A.C. (J. Infect. Dis. 2006) 3 23

Products for CD247 Gene

  • Addgene plasmids for CD247

Sources for CD247 Gene

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