Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD244 Gene

Aliases for CD244 Gene

  • CD244 Molecule, Natural Killer Cell Receptor 2B4 2 3
  • NKR2B4 3 4 6
  • SLAMF4 3 4 6
  • NAIL 3 4 6
  • Signaling Lymphocytic Activation Molecule 4 3 4
  • NK Cell Type I Receptor Protein 2B4 3 4
  • NK Cell Activation-Inducing Ligand 3 4
  • Natural Killer Cell Receptor 2B4 2 3
  • SLAM Family Member 4 3 4
  • H2B4 3 4
  • 2B4 3 4
  • NK Cell Activation Inducing Ligand NAIL 3
  • CD244 Natural Killer Cell Receptor 2B4 2
  • CD244 Antigen 4
  • Nmrk 3

External Ids for CD244 Gene

Previous GeneCards Identifiers for CD244 Gene

  • GC01M158591
  • GC01M156532
  • GC01M157577
  • GC01M158016
  • GC01M157613
  • GC01M159066
  • GC01M132156

Summaries for CD244 Gene

Entrez Gene Summary for CD244 Gene

  • This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

GeneCards Summary for CD244 Gene

CD244 (CD244 Molecule, Natural Killer Cell Receptor 2B4) is a Protein Coding gene. Diseases associated with CD244 include rheumatoid arthritis. Among its related pathways are Hemostasis and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for CD244 Gene

  • Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

Gene Wiki entry for CD244 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD244 Gene

Genomics for CD244 Gene

Regulatory Elements for CD244 Gene

Genomic Location for CD244 Gene

160,830,160 bp from pter
160,862,902 bp from pter
32,743 bases
Minus strand

Genomic View for CD244 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD244 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD244 Gene

Proteins for CD244 Gene

  • Protein details for CD244 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Natural killer cell receptor 2B4
    Protein Accession:
    Secondary Accessions:
    • Q5VYI2
    • Q5VYI6
    • Q5VYI7
    • Q96T47
    • Q9NQD2
    • Q9NQD3
    • Q9Y288

    Protein attributes for CD244 Gene

    370 amino acids
    Molecular mass:
    41616 Da
    Quaternary structure:
    • Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.

    Alternative splice isoforms for CD244 Gene


neXtProt entry for CD244 Gene

Proteomics data for CD244 Gene at MOPED

Post-translational modifications for CD244 Gene

  • N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.
  • Glycosylation at Asn71, Asn77, Asn89, Asn164, Asn181, Asn192, Asn200, and Asn213
  • Modification sites at PhosphoSitePlus

Other Protein References for CD244 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD244 (2B4/CD244/SLAMF4)

No data available for DME Specific Peptides for CD244 Gene

Domains for CD244 Gene

Gene Families for CD244 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD244 Gene

Suggested Antigen Peptide Sequences for CD244 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZW8
  • Contains 2 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CD244: view

Function for CD244 Gene

Molecular function for CD244 Gene

UniProtKB/Swiss-Prot Function: Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

Gene Ontology (GO) - Molecular Function for CD244 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 18296487
genes like me logo Genes that share ontologies with CD244: view

Phenotypes for CD244 Gene

genes like me logo Genes that share phenotypes with CD244: view

Animal Models for CD244 Gene

MGI Knock Outs for CD244:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD244 Gene

Localization for CD244 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD244 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD244 Gene COMPARTMENTS Subcellular localization image for CD244 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CD244 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD244: view

Pathways for CD244 Gene

genes like me logo Genes that share pathways with CD244: view

Pathways by source for CD244 Gene

2 Reactome pathways for CD244 Gene
1 KEGG pathway for CD244 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD244 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10358138
GO:0007596 blood coagulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CD244: view

Compounds for CD244 Gene

(4) Novoseek inferred chemical compound relationships for CD244 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 42.5 7
ly294002 25.6 2
phosphoinositide 15.8 3
lipid 0 4
genes like me logo Genes that share compounds with CD244: view

Transcripts for CD244 Gene

Unigene Clusters for CD244 Gene

CD244 molecule, natural killer cell receptor 2B4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD244

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD244 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: -
SP6: - - - - - -

Relevant External Links for CD244 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD244 Gene

mRNA expression in normal human tissues for CD244 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD244 Gene

This gene is overexpressed in Whole Blood (23.5) and Spleen (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD244 Gene

SOURCE GeneReport for Unigene cluster for CD244 Gene Hs.157872

mRNA Expression by UniProt/SwissProt for CD244 Gene

Tissue specificity: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.
genes like me logo Genes that share expressions with CD244: view

In Situ Assay Products

Orthologs for CD244 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD244 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD244 35
  • 98.08 (n)
  • 94.81 (a)
CD244 36
  • 95 (a)
(Bos Taurus)
Mammalia CD244 35
  • 73.13 (n)
  • 60.11 (a)
CD244 36
  • 57 (a)
(Canis familiaris)
Mammalia CD244 35
  • 70.93 (n)
  • 57.93 (a)
CD244 36
  • 49 (a)
(Mus musculus)
Mammalia Cd244 35
  • 68.34 (n)
  • 54.32 (a)
Cd244 16
Cd244 36
  • 48 (a)
(Monodelphis domestica)
Mammalia CD244 36
  • 32 (a)
(Rattus norvegicus)
Mammalia Cd244 35
  • 61.4 (n)
  • 44.91 (a)
(Gallus gallus)
Aves CD244 35
  • 46.21 (n)
  • 33.22 (a)
CD244 36
  • 26 (a)
Species with no ortholog for CD244:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD244 Gene

Gene Tree for CD244 (if available)
Gene Tree for CD244 (if available)

Paralogs for CD244 Gene

No data available for Paralogs for CD244 Gene

Variants for CD244 Gene

Sequence variations from dbSNP and Humsavar for CD244 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs480104 -- 160,831,256(-) GAACA(C/G)TTCCT utr-variant-3-prime
rs483197 -- 160,851,877(-) tATTT(G/T)TGTGT intron-variant
rs485618 -- 160,830,690(-) TCTCT(A/C/G/T)AGTAG utr-variant-3-prime
rs489651 -- 160,851,190(-) gttga(C/T)caccg intron-variant
rs489910 -- 160,842,786(-) AGAGG(C/G)AAGTG intron-variant

Relevant External Links for CD244 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD244 Gene

Disorders for CD244 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD244 Gene including...

Search for CD244 Gene in MalaCards »

(1) OMIM Diseases for CD244 Gene (605554)

(6) Novoseek inferred disease relationships for CD244 Gene

Disease -log(P) Hits PubMed IDs
x-linked lymphoproliferative syndrome 91.9 4
lymphoproliferative syndrome 89.7 4
ebv infections 46.8 1
tumors 7.82 3
necrosis 0 2

Relevant External Links for CD244

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD244: view

No data available for UniProtKB/Swiss-Prot for CD244 Gene

Publications for CD244 Gene

  1. Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4. (PMID: 10458320) Boles K.S. … Mathew P.A. (Tissue Antigens 1999) 2 3 4 23
  2. Functional role of human NK cell receptor 2B4 (CD244) isoforms. (PMID: 19499526) Mathew S.O. … Mathew P.A. (Eur. J. Immunol. 2009) 3 4 23
  3. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. (PMID: 10358138) Tangye S.G. … Phillips J.H. (J. Immunol. 1999) 3 4 23
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein. (PMID: 21606496) Margraf-Schonfeld S. … Watzl C. (J. Biol. Chem. 2011) 3 4

Products for CD244 Gene

Sources for CD244 Gene

Back to Top