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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD24 Gene

protein-coding   GIFtS: 54
GCID: GC0YM021152

CD24 molecule

(Previous name: CD24 antigen (small cell lung carcinoma cluster 4 antigen)...)
 Explore 52 diseases affiliated with
CD24 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD24    

Aliases
for CD24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD24 Molecule1 2
CD24A1 2 3
CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen)1 2
Signal Transducer CD242
CD24 Antigen3
Small Cell Lung Carcinoma Cluster 4 Antigen3

External Ids:    HGNC: 16451   Entrez Gene: 1001339412   OMIM: 6000745   UniProtKB: P250633   

Export aliases for CD24 gene to outside databases

Previous GC identifers: GC0YM020359 GC06U900001 GC0YM020047 GC0YM019540 GC0YM019611


Summaries
for CD24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD24:
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein
is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to
the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes
AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells

Gene Wiki entry for CD24


Genomic Views
for CD24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD24 gene promoter:
         Nkx3-1   Max1   Nkx3-1 v1   POU3F2   Nkx3-1 v2   SRY   FOXC1   Nkx3-1 v3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD24 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   HGNC cytogenetic band: 6q21

CD24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD24 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM021152:  view genomic region     (about GC identifiers)

Start:
 21,152,526 bp from pter      End:
 21,154,705 bp from pter
Size:
 2,180 bases      Orientation:
 minus strand
CD24 has overlapping exons with:
 CD24P4

Proteins
for CD24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD24_HUMAN, P25063 (See protein sequence)
Recommended Name: Signal transducer CD24 precursor  
Size: 80 amino acids; 8097 Da
Subunit: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the
erythroleukemia cell line K-562 and in Burkitt's lymphoma
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence caution: Sequence=AAD14170.1; Type=Erroneous initiation;
Secondary accessions: Q16257 Q53XS0

Explore the universe of human proteins at neXtProt for CD24: NX_P25063

Post-translational modifications:

  • Extensively O-glycosylated1
  • View neXtProt modification sites for NX_P25063

    • CD24 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_037362.1  Reactome Protein details: P25063
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD24
    Enzo Life Sciences proteins for CD24
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CD24 
    GenScript Custom Purified and Recombinant Proteins Services for CD24
    Novus Biologicals CD24 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD24

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA16532032
    GO:0016020membrane IDA10037815
    GO:0031225anchored to membrane IEA--
    GO:0045121membrane raft IDA11313396


    CD24 for ontologies           About GeneDecksing



    CD24 Antibody Products: 
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    ThermoFisher Antibodies for CD24

    Assay Products for CD24: 
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    Uscn ELISAs and CLIAs for CD24

    Protein Domains /
    Families
    for CD24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P25063

    UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
    Similarity: Belongs to the CD24 family


    Function
    for CD24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
    Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to
    the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes
    AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells
    Induction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells

         Genatlas biochemistry entry for CD24:
    cell differentiation antigen CD24,glycosyl phosphatidylinositol (GPI) linked membrane sialoglycoprotein,identified by
    monoclonal antibodies BA-1,VIB-E3,expressed on granulocyte,B lymphocyte,brain,kidney,regenerating muscle,(? involved
    in signal transduction),with cell-type specific promoter activity in small cell lung cancer

    miRNA
    Products:            		miRTarBase miRNAs that target CD24:
    hsa-mir-373 (MIRT002501)

    OriGene 3'-UTR Clone: CD24
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD24
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CD24 (see all 15):
    hsa-miR-3163 hsa-miR-4317 hsa-miR-26a-2* hsa-miR-561 hsa-miR-627 hsa-miR-551b* hsa-miR-587 hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CD24 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD24 (see all 4)
    OriGene shRNA RFP: CD24
    OriGene siRNA: CD24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD24

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD24

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD24 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD24
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD24 (NM_198053)
    Sino Biological Human cDNA Clone for CD24
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD24 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD24
    LifeMap BioReagents: cell lines associated with CD24: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem MEL2, NCr-fac Progenitor, PureStem Progenitor E68

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD24

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS8213086
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI8753773
    GO:0030296protein tyrosine kinase activator activity IDA11313396


    CD24 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cd24atm1Pjln for CD24
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd24a):
     cellular  hematopoietic system  immune system  reproductive system 

    CD24 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    2Hematopoietic cell lineage
    		Hematopoietic cell lineage1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for CD24
        L1CAM interactions
    Developmental Biology
    Axon guidance


    1         Kegg Pathway  (Kegg details for CD24):
        Hematopoietic cell lineage


    CD24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD24

    5/6 Interacting proteins for CD24 (P250631, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYNP079481, 3EBI-6267018,EBI-79452 I2D: score=2 
    FGRP097693I2D: score=2 
    SELPP161093I2D: score=2 
    HMGB1P094293I2D: score=1 
    SIGLEC10Q96LC73I2D: score=1 
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEP15174142
    GO:0001775cell activation IDA8223854
    GO:0001959regulation of cytokine-mediated signaling pathway ISS16390867
    GO:0002237response to molecule of bacterial origin ISS15493995
    GO:0002768immune response-regulating cell surface receptor signaling pathway IC11313396


    CD24 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD24
    Search CenterWatch for drugs/clinical trials and news about CD24 

    Transcripts
    for CD24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD24 gene: 
    NM_013230.2  

    Unigene Cluster for CD24:

    CD24 molecule
    Hs.644105  [show with all ESTs]
    Unigene Representative Sequence: AK125531

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CD24
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD24
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CD24 (see all 15):
    hsa-miR-3163 hsa-miR-4317 hsa-miR-26a-2* hsa-miR-561 hsa-miR-627 hsa-miR-551b* hsa-miR-587 hsa-miR-582-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CD24 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD24 (see all 4)
    OriGene shRNA RFP: CD24
    OriGene siRNA: CD24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD24
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD24
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD24 (NM_198053)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD24 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD24
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD24
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD24

    Additional cDNA sequence: 

    AK026603.1 AK125531.1 BC064619.1 BT007404.1 D87667.1 DQ530230.1 DQ530231.1 DQ530232.1 
    DQ530233.1 DQ530234.1 L33930.1 M58664.1 S75311.1 X69397.1 

    24/53 DOTS entries (see all 53):

    DT.100882108  DT.100882117  DT.95085902  DT.87078331  DT.95195116  DT.95195104  DT.95116257  DT.100882100 
    DT.86838563  DT.100882122  DT.120651633  DT.120651656  DT.92466399  DT.100882127  DT.120651710  DT.120651704 
    DT.120651787  DT.102843352  DT.100882099  DT.100882107  DT.100882121  DT.95194960  DT.100882132  DT.120651680 

    GeneLoc Exon Structure


    Expression
    for CD24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAACAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD24 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AmnionAmniotic MembraneAmniotic CellsAmnion, Extraembryonic Tissues
    BloodPeripheral BloodNeutrophilsBlood
    BloodPeripheral BloodImmature B CellsBlood
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    AdiposeVisceral White AdiposeVisceral White PreadipocytesAdipose
    BloodPeripheral BloodPre-B CellsBlood
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16) 
    NameCategory
    Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)Epithelium, Kidney
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Adult human kidney epithelial cells (Primary Cell)Kidney
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    Genevestigator expression for CD24

    SOURCE GeneReport for Unigene cluster: Hs.644105

    UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
    Tissue specificity: B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in
    erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD24: 
              Nephrotoxicity in human mouse rat
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD24

    Orthologs
    for CD24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD24 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd24a5 CD24a antigen   --   10 (23.01 cM) 43579169 

    Paralogs
    for CD24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CD24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CD24
         2 CNVs: 31588 23931
    Human Gene Mutation Database (HGMD): CD24
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD24
    DNA2.0 Custom Variant and Variant Library Synthesis for CD24

    Disorders / Diseases
    for CD24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD24 for disorders           About GeneDecksing

    OMIM gene information: 600074   
    OMIM disorders: 126200  
    UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
  • Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A
    • multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized
    by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens
    (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated
    by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders,
    paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and
    environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic
    modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24
    expression on the cell surface

    20/52 diseases for CD24 (see all 52):    About MalaCards
    lung carcinoma    adult mesoblastic nephroma    carcinoma    non-small cell lung carcinoma
    common variable immunodeficiency    clear cell renal cell carcinoma    paresthesia    multiple sclerosis
    esophageal squamous cell carcinoma    systemic lupus erythematosus    renal cell carcinoma    squamous cell carcinoma
    lupus erythematosus    pancreatic ductal adenocarcinoma    inflammatory bowel disease    ductal carcinoma in situ
    spastic ataxia    intrahepatic cholangiocarcinoma    burkitt's lymphoma    ulcerative colitis

    2 diseases from the University of Copenhagen DISEASES database for CD24:
    Breast cancer     Leukemia
    Genetic Association Database (GAD): CD24
    Human Genome Epidemiology (HuGE) Navigator: CD24 (12 documents)

    Export disorders for CD24 gene to outside databases

    Publications
    for CD24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD24 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with CD24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CD24 is a genetic modifier for risk and progression of multiple sclerosis. (PubMed id 14657362)1, 2, 4 Zhou Q.... Liu Y. (2003)
    2. Mapping of CD24 and homologous sequences to multiple chromosomal loci. (PubMed id 7959762)1, 2, 3 Hough M.R.... Humphries R.K. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. (PubMed id 11313396)1, 2 Suzuki T....Fujimoto J. (2001)
    5. Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line. (PubMed id 8753773)1, 2 Zarn J.A.... Stahel R.A. (1996)
    6. The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21. (PubMed id 7736776)1, 2 Zarn J.A.... Stahel R.A. (1995)
    7. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. (PubMed id 1327504)1, 2 Jackson D.... Stahel R.A. (1992)
    8. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. (PubMed id 1831224)1, 2 Kay R.... Humphries R.K. (1991)
    9. Prognostic significance of CD24 and claudin-7 immunoe xpression in ductal invasive breast cancer. (PubMed id 21956537)1 Bernardi M.A....Brentani M.M. (2012)
    10. CD24 gene allele variation is not associated with olig oclonal IgG bands and IgG index of multiple sclerosis patients. (PubMed id 22262195)1 Saadatnia M....Maghzi A.H. (2012)

    External Searches for CD24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CD24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100133941 HGNC: 1645 euGenes: HUgn100133941 ECgene: CD24
    Kegg: 100133941 H-InvDB: CD24

    Other Databases showing CD24 gene

    (According to HUGE)
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    Specialized Databases showing CD24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD24 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CD24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for CD24 gene:
    Search GeneIP for patents involving CD24

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     CD24 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with CD24: PureStem 4D20.8, NCr-fac Progenitor,
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