 |
 | Services
| |
 |
Aliases &
Descriptions
for CD24
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CD24A 1, 2, 3 | | FLJ22950 2 | | FLJ43543 2 | | MGC75043 2 |
| | | Descriptions |
|---|
| CD24 antigen 2, 3 | | CD24 antigen (small cell lung carcinoma cluster 4 antigen) 1, 2 | | CD24 molecule 2 | | Small cell lung carcinoma cluster 4 antigen 3 |
|
| |
Search outside databases for aliases for CD24 genePrevious GC identifers: GC0YM020359 GC06U900001 GC0YM020047 GC0YM019540 |
Summaries
for CD24(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CD24:
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells.
The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell
surface. [provided by RefSeq]
UniProtKB/Swiss-Prot: CD24_HUMAN, P25063Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a
lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers
derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their
terminal differentiation into antibody-forming cells |
Genomic Location
for CD24
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the CD24 gene 
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: Yq11.222 HGNC cytogenetic band: 6q21CD24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YM019611:
(about GC identifiers)
Start:
|
19,611,898 bp from pter |
End:
|
19,614,093 bp from pter |
Size:
|
2,196 bases |
Orientation:
|
minus strand |
1 alternative location:
| Proteins
for CD24
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD24_HUMAN, P25063 (See
protein sequence)Recommended Name: Signal transducer CD24 precursor Size: 80 amino acids; 8097 Da
Subunit: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell
cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q16257 Q53XS0Post-translational modifications:
Extensively O-glycosylated1
REFSEQ proteins: NP_037362.1
ENSEMBL proteins: ENSP00000372291
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005624 | membrane fraction |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | | GO:0009897 | external side of plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- | | GO:0031362 | anchored to external side of plasma membrane |
IEA | -- |
About this table
Antibodies for CD24:
Assays for CD24: | Protein
Domains/
Families
for CD24(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P25063 UniProtKB/Swiss-Prot: CD24_HUMAN, P25063Similarity: Belongs to the CD24 family | Gene Function
for CD24
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
 Applied Biosystems Silencer® siRNAs for CD24
 Sigma-Aldrich siRNA for CD24
Sigma-Aldrich shRNA Panels and shRNA for CD24
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_013230
Myc/DDK tagged cDNA clone in CMV expression vector: NM_013230
untagged cDNA clones in CMV expression vector (see all 2): BC064619
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_013230
UniProtKB/Swiss-Prot: CD24_HUMAN, P25063Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a
lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers
derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their
terminal differentiation into antibody-forming cellsInduction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming
cellsGenatlas biochemistry entry for CD24:cell differentiation antigen CD24,glycosyl phosphatidylinositol (GPI) linked membrane
sialoglycoprotein,identified by monoclonal antibodies BA-1,VIB-E3,expressed on granulocyte,B
lymphocyte,brain,kidney,regenerating muscle,(? involved in signal transduction),with cell-type
specific promoter activity in small cell lung cancer2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cd24a):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions
for CD24
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for CD24
--5/49 Gene Ontology (GO) biological process terms (links to tree view) (see all 49
): About this table
|
Drugs & Compounds
for CD24(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CD24
|
Transcripts
for CD24(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for CD24
Sigma-Aldrich shRNA Panels and shRNA for CD24
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_013230 REFSEQ mRNAs for CD24 gene: NM_013230.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_013230
OriGene GFP tagged cDNA clone in CMV expression vector: NM_013230
Myc/DDK tagged cDNA clone in CMV expression vector: NM_013230
untagged cDNA clones in CMV expression vector (see all 2): BC064619
Additional cDNA sequence: AK026603.1 AK125531.1 BC064619.1 BT007404.1 CR591421.1 CR598378.1 CR609933.1 CR623460.1 D87667.1 DQ530230.1 DQ530231.1 DQ530232.1 DQ530233.1 DQ530234.1 L33930.1 M58664.1 S75311.1 X69397.1 24/46 DOTS entries (see all 46
): DT.100882108 DT.95085902 DT.100882117 DT.95195116 DT.87078331 DT.95195104 DT.95116257 DT.100882100 DT.100882122 DT.120651633 DT.86838563 DT.120651656 DT.100882127 DT.120651710 DT.92466399 DT.120651704 DT.120651787 DT.102843352 DT.120651680 DT.100882110 DT.100882112 DT.95194960 DT.100882099 DT.100882121
 highest scoring ESTs for CD24:L33930 AA307984 AA308647 AA740268 AK026603 AK125531 AL533785 AL534134 AL534460 AL534949 Unigene Cluster for CD24: CD24 molecule Hs.694721 [show with all ESTs]Unigene Representative Sequence: AK125531
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000382840
|
Expression
for CD24
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CD24 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CD24
1 / 2 / 3 13 probe-sets matching CD24 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.694721
Expression variation in blood from EXPOLDB for CD24 UniProtKB/Swiss-Prot: CD24_HUMAN, P25063Tissue specificity: B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa.
Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the
surface of T-cells |
Orthologs
for CD24
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD24 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Cd24a5 |
10 (26.00 cM) |
CD24a antigen |
-- |
X72910
|
About this table Species with no ortholog for CD24
ENSEMBL Gene Tree for CD24 | Paralogs
for CD24(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for CD24(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for CD24
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600074 disorders: 126200 UniProtKB/Swiss-Prot: CD24_HUMAN, P25063
Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS)
[MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of
focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral
nerves are not affected. Onset usually in third or fourth decade with intermittent progression
over an extended period. The cause is still uncertain1 PharmGKB disease relationship for CD24 geneAbout this table
Human Gene Mutation Database: CD24
Genetic Association Database: CD24
|
Medical News
for CD24(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CD24 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/66 PubMed articles for CD24 gene (see all 66
):- CD24 is a genetic modifier for risk and progression of multiple sclerosis. (PubMed id 14657362)3, 4, 6 Zhou Q.... Liu Y. (2003)
- Mapping of CD24 and homologous sequences to multiple chromosomal loci. (PubMed id 7959762)2, 3, 4 Hough M.R.... Humphries R.K. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. (PubMed id 11313396)3, 4 Suzuki T....Fujimoto J. (2001)
- Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line. (PubMed id 8753773)3, 4 Zarn J.A.... Stahel R.A. (1996)
- The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21. (PubMed id 7736776)3, 4 Zarn J.A.... Stahel R.A. (1995)
- CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. (PubMed id 1327504)3, 4 Jackson D.... Stahel R.A. (1992)
- CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. (PubMed id 1831224)3, 4 Kay R.... Humphries R.K. (1991)
- Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. (PubMed id 19043399)3 Baumhoer D....Terracciano L.M. (2009)
- CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma. (PubMed id 19050962)3 Sano A....Kuwano H. (2009)
|
Search for CD24
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD24
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CD24
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD24(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for CD24(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for CD24:
 | |
 | | | | |
 |
 |  |  | |
|  | Recombinant Proteins
(CD24) | | | Antibodies (CD24) |
| | | | Search Tocris compounds for CD24 |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
