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Aliases for CD24 Gene

Aliases for CD24 Gene

  • CD24 Molecule 2 3 5
  • CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen) 2 3
  • CD24A 3 4
  • Small Cell Lung Carcinoma Cluster 4 Antigen 4
  • Signal Transducer CD24 3
  • CD24 Antigen 4

External Ids for CD24 Gene

Previous GeneCards Identifiers for CD24 Gene

  • GC0YM020359
  • GC06U900001
  • GC0YM020047
  • GC0YM019540
  • GC0YM019611
  • GC0YM021152

Summaries for CD24 Gene

Entrez Gene Summary for CD24 Gene

  • This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CD24 Gene

CD24 (CD24 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage and Developmental Biology. GO annotations related to this gene include protein kinase binding and carbohydrate binding.

UniProtKB/Swiss-Prot for CD24 Gene

  • May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

Gene Wiki entry for CD24 Gene

Additional gene information for CD24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD24 Gene

Genomics for CD24 Gene

Regulatory Elements for CD24 Gene

Enhancers for CD24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H106997 0.7 ENCODE 0.3 -21.3 -21264 1 CTCF ZNF792 SAP130 ZNF644 ZNF2 RAD21 SMC3 ZNF143 HOMEZ GATAD2A C6orf203 QRSL1 RTN4IP1 CD24
GH06H107021 0.5 ENCODE 0.2 -45.1 -45077 0 JUND JUN FOS CUX1 SP7 C6orf203 CD24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD24 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD24 Gene

Chromosome:
6
Start:
106,969,831 bp from pter
End:
106,976,855 bp from pter
Size:
7,025 bases
Orientation:
Minus strand

Genomic View for CD24 Gene

Genes around CD24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD24 Gene

Proteins for CD24 Gene

  • Protein details for CD24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25063-CD24_HUMAN
    Recommended name:
    Signal transducer CD24
    Protein Accession:
    P25063
    Secondary Accessions:
    • Q16257
    • Q53XS0

    Protein attributes for CD24 Gene

    Size:
    80 amino acids
    Molecular mass:
    8097 Da
    Quaternary structure:
    • Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitts lymphoma.
    SequenceCaution:
    • Sequence=AAD14170.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CD24 Gene

Post-translational modifications for CD24 Gene

Antibody Products

  • Abcam antibodies for CD24

Protein Products

  • Abcam proteins for CD24

No data available for DME Specific Peptides for CD24 Gene

Domains & Families for CD24 Gene

Gene Families for CD24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CD24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD24 Gene

Graphical View of Domain Structure for InterPro Entry

P25063

UniProtKB/Swiss-Prot:

CD24_HUMAN :
  • Belongs to the CD24 family.
Family:
  • Belongs to the CD24 family.
genes like me logo Genes that share domains with CD24: view

Function for CD24 Gene

Molecular function for CD24 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD24,glycosyl phosphatidylinositol (GPI) linked membrane sialoglycoprotein,identified by monoclonal antibodies BA-1,VIB-E3,expressed on granulocyte,B lymphocyte,brain,kidney,regenerating muscle,(? involved in signal transduction),with cell-type specific promoter activity in small cell lung cancer
UniProtKB/Swiss-Prot Function:
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

Gene Ontology (GO) - Molecular Function for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 8213086
GO:0005515 protein binding IPI 8753773
GO:0019901 protein kinase binding IPI 8753773
GO:0030296 protein tyrosine kinase activator activity IDA 11313396
genes like me logo Genes that share ontologies with CD24: view
genes like me logo Genes that share phenotypes with CD24: view

Animal Model Products

CRISPR Products

miRNA for CD24 Gene

miRTarBase miRNAs that target CD24

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD24 Gene

Localization for CD24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD24 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0009986 cell surface IDA 16532032
GO:0016020 membrane IDA 10037815
GO:0031362 anchored component of external side of plasma membrane IBA --
GO:0045121 membrane raft IDA 11313396
genes like me logo Genes that share ontologies with CD24: view

No data available for Subcellular locations from COMPARTMENTS for CD24 Gene

Pathways & Interactions for CD24 Gene

genes like me logo Genes that share pathways with CD24: view

Pathways by source for CD24 Gene

3 Reactome pathways for CD24 Gene
1 KEGG pathway for CD24 Gene
1 R&D Systems pathway for CD24 Gene

Interacting Proteins for CD24 Gene

Gene Ontology (GO) - Biological Process for CD24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEP 15174142
GO:0001775 cell activation IDA 8223854
GO:0001959 regulation of cytokine-mediated signaling pathway ISS 16390867
GO:0002237 response to molecule of bacterial origin ISS 15493995
GO:0002768 immune response-regulating cell surface receptor signaling pathway IC 11313396
genes like me logo Genes that share ontologies with CD24: view

No data available for SIGNOR curated interactions for CD24 Gene

Drugs & Compounds for CD24 Gene

No Compound Related Data Available

Transcripts for CD24 Gene

mRNA/cDNA for CD24 Gene

(4) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD24 Gene

CD24 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD24 Gene

No ASD Table

Relevant External Links for CD24 Gene

GeneLoc Exon Structure for
CD24
ECgene alternative splicing isoforms for
CD24

Expression for CD24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD24 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD24 Gene:

CD24

SOURCE GeneReport for Unigene cluster for CD24 Gene:

Hs.644105

mRNA Expression by UniProt/SwissProt for CD24 Gene:

P25063-CD24_HUMAN
Tissue specificity: B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
genes like me logo Genes that share expression patterns with CD24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD24 Gene

Orthologs for CD24 Gene

Evolution for CD24 Gene

ENSEMBL:
Gene Tree for CD24 (if available)
TreeFam:
Gene Tree for CD24 (if available)

No data available for Orthologs for CD24 Gene

Paralogs for CD24 Gene

Pseudogenes.org Pseudogenes for CD24 Gene

genes like me logo Genes that share paralogs with CD24: view

No data available for Paralogs for CD24 Gene

Variants for CD24 Gene

Sequence variations from dbSNP and Humsavar for CD24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000269633 -- 106,974,081(+) CAACT(C/G)CGAGG intron-variant, upstream-variant-2KB
rs1000635744 -- 106,978,818(+) TGGTT(A/G)AATGG upstream-variant-2KB
rs1000863675 -- 106,972,628(+) GAGTG(C/G)CATCA intron-variant
rs1001358454 -- 106,972,304(+) CTAGG(C/T)AACTT intron-variant
rs1001642494 -- 106,977,427(+) GTTCC(C/T)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD24 Gene

Variant ID Type Subtype PubMed ID
esv2732546 CNV deletion 23290073
nsv508425 CNV deletion 20534489
nsv509145 CNV insertion 20534489
nsv510909 OTHER complex 20534489

Relevant External Links for CD24 Gene

Human Gene Mutation Database (HGMD)
CD24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CD24 Gene

Disorders for CD24 Gene

UniProtKB/Swiss-Prot

CD24_HUMAN
  • Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269 PubMed:14657362}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for CD24

Genetic Association Database (GAD)
CD24
Human Genome Epidemiology (HuGE) Navigator
CD24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD24

No disorders were found for CD24 Gene.

No data available for MalaCards and Genatlas for CD24 Gene

Publications for CD24 Gene

  1. CD24 is a genetic modifier for risk and progression of multiple sclerosis. (PMID: 14657362) Zhou Q … Liu Y (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 45 60
  2. Mapping of CD24 and homologous sequences to multiple chromosomal loci. (PMID: 7959762) Hough MR … Humphries RK (Genomics 1994) 2 3 4 60
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 45 60
  4. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PMID: 20378664) Sombekke MH … Uitdehaag BM (Multiple sclerosis (Houndmills, Basingstoke, England) 2010) 3 45 60
  5. CD24 gene exon 2 dimorphism does not affect disease susceptibility in Japanese sarcoidosis patients. (PMID: 21086907) Tanizawda K … Mishima M (Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2010) 3 45 60

Products for CD24 Gene

Sources for CD24 Gene

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