Aliases for CD226 Gene
External Ids for CD226 Gene
Previous GeneCards Identifiers for CD226 Gene
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for CD226 Gene
CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Autoimmune Polyendocrinopathy Type 2 and Refractory Celiac Disease. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include protein kinase binding and cell adhesion molecule binding.
UniProtKB/Swiss-Prot for CD226 Gene
Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.