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Aliases for CD226 Gene

Aliases for CD226 Gene

  • CD226 Molecule 2 3
  • DNAX Accessory Molecule 1 3 4
  • CD226 Antigen 2 4
  • DNAM-1 3 4
  • DNAM1 3 4
  • T Lineage-Specific Activation Antigen 1 Antigen 3
  • Platelet And T Cell Activation Antigen 1 3
  • DNAX Accessory Molecule-1 3
  • Adhesion Glycoprotein 3
  • TLiSA1 3
  • PTA1 3

External Ids for CD226 Gene

Previous GeneCards Identifiers for CD226 Gene

  • GC18M067315
  • GC18M065679
  • GC18M065681
  • GC18M067528
  • GC18M064248

Summaries for CD226 Gene

Entrez Gene Summary for CD226 Gene

  • This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CD226 Gene

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include refractory celiac disease and ovarian cystic teratoma. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include protein kinase binding and cell adhesion molecule binding.

UniProtKB/Swiss-Prot for CD226 Gene

  • Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Gene Wiki entry for CD226 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD226 Gene

Genomics for CD226 Gene

Regulatory Elements for CD226 Gene

Genomic Location for CD226 Gene

Chromosome:
18
Start:
69,831,158 bp from pter
End:
69,961,803 bp from pter
Size:
130,646 bases
Orientation:
Minus strand

Genomic View for CD226 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD226 Gene

Proteins for CD226 Gene

  • Protein details for CD226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15762-CD226_HUMAN
    Recommended name:
    CD226 antigen
    Protein Accession:
    Q15762
    Secondary Accessions:
    • B2R818

    Protein attributes for CD226 Gene

    Size:
    336 amino acids
    Molecular mass:
    38614 Da
    Quaternary structure:
    • Interacts with PVR and PVRL2.

neXtProt entry for CD226 Gene

Proteomics data for CD226 Gene at MOPED

Post-translational modifications for CD226 Gene

  • Ubiquitination at Lys 295
  • Glycosylation at Asn 32, Asn 83, Asn 90, Asn 97, Asn 147, Asn 186, Asn 198, and Asn 231
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD226 Gene

Domains & Families for CD226 Gene

Gene Families for CD226 Gene

Protein Domains for CD226 Gene

Suggested Antigen Peptide Sequences for CD226 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15762

UniProtKB/Swiss-Prot:

CD226_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CD226: view

Function for CD226 Gene

Molecular function for CD226 Gene

UniProtKB/Swiss-Prot Function:
Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Gene Ontology (GO) - Molecular Function for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005178 integrin binding IPI 16831868
GO:0005515 protein binding IPI 21982860
GO:0019901 protein kinase binding IPI 16831868
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with CD226: view
genes like me logo Genes that share phenotypes with CD226: view

Animal Models for CD226 Gene

MGI Knock Outs for CD226:

Animal Model Products

miRNA for CD226 Gene

miRTarBase miRNAs that target CD226

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD226

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD226 Gene

Localization for CD226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD226 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD226 Gene COMPARTMENTS Subcellular localization image for CD226 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8673704
GO:0005913 cell-cell adherens junction IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 16831868
genes like me logo Genes that share ontologies with CD226: view

Pathways & Interactions for CD226 Gene

genes like me logo Genes that share pathways with CD226: view

Pathways by source for CD226 Gene

Gene Ontology (GO) - Biological Process for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IDA 16831868
GO:0007155 cell adhesion TAS 8673704
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
genes like me logo Genes that share ontologies with CD226: view

No data available for SIGNOR curated interactions for CD226 Gene

Drugs & Compounds for CD226 Gene

(2) Drugs for CD226 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
tyrosine Nutra 547

(1) Additional Compounds for CD226 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
genes like me logo Genes that share compounds with CD226: view

Transcripts for CD226 Gene

Unigene Clusters for CD226 Gene

CD226 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD226

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD226 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for CD226 Gene

GeneLoc Exon Structure for
CD226
ECgene alternative splicing isoforms for
CD226

Expression for CD226 Gene

mRNA expression in normal human tissues for CD226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD226 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.4), Platelet (25.2), and Monocytes (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD226 Gene



SOURCE GeneReport for Unigene cluster for CD226 Gene Hs.660130

mRNA Expression by UniProt/SwissProt for CD226 Gene

Q15762-CD226_HUMAN
Tissue specificity: Expressed by peripheral blood T-lymphocytes.
genes like me logo Genes that share expression patterns with CD226: view

Protein tissue co-expression partners for CD226 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD226 Gene

Orthologs for CD226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD226 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD226 35
  • 72.89 (n)
  • 59.04 (a)
CD226 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD226 35
  • 77.17 (n)
  • 66.97 (a)
CD226 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd226 35
  • 68.89 (n)
  • 54.24 (a)
Cd226 16
Cd226 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD226 35
  • 99.31 (n)
  • 98.51 (a)
CD226 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd226 35
  • 68.09 (n)
  • 52.58 (a)
oppossum
(Monodelphis domestica)
Mammalia CD226 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD226 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD226 35
  • 50.99 (n)
  • 33.86 (a)
CD226 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD226 36
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd226 35
  • 43.7 (n)
  • 28.74 (a)
cd226 36
  • 22 (a)
OneToOne
Species with no ortholog for CD226:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD226 Gene

ENSEMBL:
Gene Tree for CD226 (if available)
TreeFam:
Gene Tree for CD226 (if available)

Paralogs for CD226 Gene

(1) SIMAP similar genes for CD226 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD226: view

No data available for Paralogs for CD226 Gene

Variants for CD226 Gene

Sequence variations from dbSNP and Humsavar for CD226 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs169554 -- 69,946,257(+) aagaa(A/G)gagag intron-variant
rs184902 -- 69,946,211(+) aaaGA(A/G)GGAAG intron-variant
rs285216 -- 69,953,038(+) atgga(C/T)ataat intron-variant
rs285217 -- 69,957,934(+) GTCTT(A/C)TAAGT upstream-variant-2KB, intron-variant
rs481014 -- 69,943,131(-) GTAAT(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD226 Gene

Variant ID Type Subtype PubMed ID
esv32736 CNV Gain+Loss 17666407
esv2717304 CNV Deletion 23290073
nsv909867 CNV Gain 21882294
nsv2347 CNV Insertion 18451855

Variation tolerance for CD226 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD226 Gene

HapMap Linkage Disequilibrium report
CD226
Human Gene Mutation Database (HGMD)
CD226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD226 Gene

Disorders for CD226 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD226 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractory celiac disease
  • refractory cd
ovarian cystic teratoma
autoimmune polyendocrinopathy type 2
  • autoimmune polyendocrine syndrome type 2
mature teratoma of the ovary
  • mature teratoma of ovary
wegener granulomatosis
  • wegener's granulomatosis
- elite association
Search CD226 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD226

Genetic Association Database (GAD)
CD226
Human Genome Epidemiology (HuGE) Navigator
CD226
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD226
genes like me logo Genes that share disorders with CD226: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD226 Gene

Publications for CD226 Gene

  1. Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis. (PMID: 19904767) Fasth A.E. … MalmstrAPm V. (Eur. J. Immunol. 2010) 23 67
  2. Leukocyte recruitment and ischemic brain injury. (PMID: 19579016) Yilmaz G. … Granger D.N. (Neuromolecular Med. 2010) 23 67
  3. DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells. (PMID: 19404979) Toutirais O. … Catros V. (Eur. J. Immunol. 2009) 23 67
  4. Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation. (PMID: 19748980) Fionda C. … Cippitelli M. (J. Immunol. 2009) 23 67
  5. Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. (PMID: 19801517) Carlsten M. … Malmberg K.J. (J. Immunol. 2009) 23 67

Products for CD226 Gene

Sources for CD226 Gene

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