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Aliases for CD226 Gene

Aliases for CD226 Gene

  • CD226 Molecule 2 3
  • CD226 Antigen 2 3 4
  • DNAX Accessory Molecule 1 3 4
  • DNAM-1 3 4
  • DNAM1 3 4
  • T Lineage-Specific Activation Antigen 1 Antigen 3
  • Platelet And T Cell Activation Antigen 1 3
  • DNAX Accessory Molecule-1 3
  • Adhesion Glycoprotein 3
  • TLiSA1 3
  • DNAM1, 6
  • PTA1 3

External Ids for CD226 Gene

Previous GeneCards Identifiers for CD226 Gene

  • GC18M067315
  • GC18M065679
  • GC18M065681
  • GC18M067528
  • GC18M064248

Summaries for CD226 Gene

Entrez Gene Summary for CD226 Gene

  • This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CD226 Gene

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include refractory celiac disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include protein kinase binding and cell adhesion molecule binding.

UniProtKB/Swiss-Prot for CD226 Gene

  • Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Gene Wiki entry for CD226 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD226 Gene

Genomics for CD226 Gene

Regulatory Elements for CD226 Gene

Genomic Location for CD226 Gene

69,831,158 bp from pter
69,961,805 bp from pter
130,648 bases
Minus strand

Genomic View for CD226 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD226 Gene

Proteins for CD226 Gene

  • Protein details for CD226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD226 antigen
    Protein Accession:
    Secondary Accessions:
    • B2R818

    Protein attributes for CD226 Gene

    336 amino acids
    Molecular mass:
    38614 Da
    Quaternary structure:
    • Interacts with PVR and PVRL2.

neXtProt entry for CD226 Gene

Proteomics data for CD226 Gene at MOPED

Post-translational modifications for CD226 Gene

  • Ubiquitination at Lys295
  • Glycosylation at Asn32, Asn83, Asn90, Asn97, Asn147, Asn186, Asn198, and Asn231
  • Modification sites at PhosphoSitePlus

Other Protein References for CD226 Gene

Antibody Products

No data available for DME Specific Peptides for CD226 Gene

Domains for CD226 Gene

Gene Families for CD226 Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD226 Gene

Suggested Antigen Peptide Sequences for CD226 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q15762
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CD226: view

Function for CD226 Gene

Molecular function for CD226 Gene

UniProtKB/Swiss-Prot Function: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Gene Ontology (GO) - Molecular Function for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 16831868
GO:0005515 protein binding IPI 21982860
GO:0019901 protein kinase binding IPI 16831868
GO:0050839 cell adhesion molecule binding IPI 12913096
genes like me logo Genes that share ontologies with CD226: view
genes like me logo Genes that share phenotypes with CD226: view

Animal Models for CD226 Gene

MGI Knock Outs for CD226:

Animal Model Products

CRISPR Products

miRNA for CD226 Gene

miRTarBase miRNAs that target CD226

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD226 Gene

Localization for CD226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD226 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD226 Gene COMPARTMENTS Subcellular localization image for CD226 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8673704
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 16831868
GO:0045121 membrane raft TAS 16831868
genes like me logo Genes that share ontologies with CD226: view

Pathways for CD226 Gene

genes like me logo Genes that share pathways with CD226: view

Pathways by source for CD226 Gene

Gene Ontology (GO) - Biological Process for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IDA 16831868
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 8673704
genes like me logo Genes that share ontologies with CD226: view

Compounds for CD226 Gene

(3) Novoseek inferred chemical compound relationships for CD226 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 7.99 3
lipid 0 5
serine 0 3
genes like me logo Genes that share compounds with CD226: view

Transcripts for CD226 Gene

Unigene Clusters for CD226 Gene

CD226 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD226

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CD226

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD226 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP3: -
SP4: -

Relevant External Links for CD226 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD226 Gene

mRNA expression in normal human tissues for CD226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD226 Gene

SOURCE GeneReport for Unigene cluster for CD226 Gene Hs.660130

mRNA Expression by UniProt/SwissProt for CD226 Gene

Tissue specificity: Expressed by peripheral blood T-lymphocytes.
genes like me logo Genes that share expressions with CD226: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD226 Gene

Orthologs for CD226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD226 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD226 35
  • 99.31 (n)
  • 98.51 (a)
CD226 36
  • 99 (a)
(Bos Taurus)
Mammalia CD226 35
  • 72.89 (n)
  • 59.04 (a)
CD226 36
  • 58 (a)
(Canis familiaris)
Mammalia CD226 35
  • 77.17 (n)
  • 66.97 (a)
CD226 36
  • 65 (a)
(Mus musculus)
Mammalia Cd226 35
  • 68.89 (n)
  • 54.24 (a)
Cd226 16
Cd226 36
  • 54 (a)
(Monodelphis domestica)
Mammalia CD226 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CD226 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Cd226 35
  • 68.09 (n)
  • 52.58 (a)
(Gallus gallus)
Aves CD226 35
  • 50.99 (n)
  • 33.86 (a)
CD226 36
  • 34 (a)
(Anolis carolinensis)
Reptilia CD226 36
  • 26 (a)
(Danio rerio)
Actinopterygii cd226 35
  • 43.7 (n)
  • 28.74 (a)
cd226 36
  • 22 (a)
Species with no ortholog for CD226:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD226 Gene

Gene Tree for CD226 (if available)
Gene Tree for CD226 (if available)

Paralogs for CD226 Gene

Selected SIMAP similar genes for CD226 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD226: view

No data available for Paralogs for CD226 Gene

Variants for CD226 Gene

Sequence variations from dbSNP and Humsavar for CD226 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs169554 -- 69,946,257(+) aagaa(A/G)gagag intron-variant
rs184902 -- 69,946,211(+) aaaGA(A/G)GGAAG intron-variant
rs285216 -- 69,953,038(+) atgga(C/T)ataat intron-variant
rs285217 -- 69,957,934(+) GTCTT(A/C)TAAGT upstream-variant-2KB, intron-variant
rs481014 -- 69,943,131(-) GTAAT(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD226 Gene

Variant ID Type Subtype PubMed ID
esv32736 CNV Gain+Loss 17666407
esv2717304 CNV Deletion 23290073
nsv909867 CNV Gain 21882294
nsv2347 CNV Insertion 18451855

Relevant External Links for CD226 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD226 Gene

Disorders for CD226 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD226 Gene including...

Search for CD226 Gene in MalaCards »

(2) Novoseek inferred disease relationships for CD226 Gene

Disease -log(P) Hits PubMed IDs
tumors 8.06 10
cancer 0 2

Relevant External Links for CD226

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD226: view

No data available for UniProtKB/Swiss-Prot for CD226 Gene

Publications for CD226 Gene

  1. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PMID: 15039383) Tahara-Hanaoka S. … Shibuya A. (Int. Immunol. 2004) 3 4 23
  2. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. (PMID: 8673704) Shibuya A. … Phillips J.H. (Immunity 1996) 2 3 4
  3. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PMID: 15607800) Pende D. … Moretta A. (Mol. Immunol. 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd J.A. … Clayton D.G. (Nat. Genet. 2007) 3 48

Products for CD226 Gene

  • Addgene plasmids for CD226

Sources for CD226 Gene

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