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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD226 Gene

protein-coding   GIFtS: 63
GCID: GC18M067528

CD226 Molecule

(Previous name: CD226 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD226 Molecule1 2     TLiSA12
CD226 Antigen1 2 3     Adhesion Glycoprotein2
DNAM12 3 5     DNAX Accessory Molecule-12
DNAM-12 3     Platelet And T Cell Activation Antigen 12
DNAX Accessory Molecule 12 3     T Lineage-Specific Activation Antigen 1 Antigen2
PTA12     

External Ids:    HGNC: 169611   Entrez Gene: 106662   Ensembl: ENSG000001506377   OMIM: 6053975   UniProtKB: Q157623   

Export aliases for CD226 gene to outside databases

Previous GC identifers: GC18M067315 GC18M065679 GC18M065681 GC18M064248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD226 Gene:
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T
cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates
cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a
role in megakaryocytic cell maturation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD226 Gene: 
CD226 (CD226 molecule) is a protein-coding gene. Diseases associated with CD226 include onchocerciasis, and addison's disease, and among its related super-pathways are Immune System and FCGR activation. GO annotations related to this gene include protein kinase binding and cell adhesion molecule binding.

UniProtKB/Swiss-Prot: CD226_HUMAN, Q15762
Function: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion
mediated by cytotoxic T-lymphocyte (CTL) and NK cell

Gene Wiki entry for CD226 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD226 gene promoter:
         STAT5B   LHX3b/Lhx3b   AP-1   ATF-2   LHX3a/Lhx3a   CUTL1   Nkx2-5   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD226 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD226

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD226


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.2   HGNC cytogenetic band: 18q22.3

CD226 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD226 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M067528:  view genomic region     (about GC identifiers)

Start:
67,498,394 bp from pter      End:
67,629,039 bp from pter
Size:
130,646 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD226_HUMAN, Q15762 (See protein sequence)
Recommended Name: CD226 antigen precursor  
Size: 336 amino acids; 38614 Da
Subunit: Interacts with PVR and PVRL2
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B2R818

Explore the universe of human proteins at neXtProt for CD226: NX_Q15762

Explore proteomics data for CD226 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15762

  • CD226 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD226 Protein Expression
    REFSEQ proteins: NP_006557.2  
    ENSEMBL proteins: 
     ENSP00000463152   ENSP00000464084   ENSP00000280200   ENSP00000462453   ENSP00000461947  
     ENSP00000463927   ENSP00000464334   ENSP00000463335  
    Reactome Protein details: Q15762
    Human Recombinant Protein Products for CD226: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD226 (DNAM-1/CD226)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD226
    OriGene Protein Over-expression Lysate for CD226
    OriGene MassSpec for CD226 
    OriGene Custom Protein Services for CD226
    GenScript Custom Purified and Recombinant Proteins Services for CD226
    Novus Biologicals CD226 Proteins
    Novus Biologicals CD226 Lysate
    Sino Biological Recombinant Protein for CD226
    Sino Biological Cell Lysate for CD226 
    ProSpec Recombinant Protein for CD226
    Cloud-Clone Corp. Proteins for CD226 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8673704
    GO:0009986cell surface IDA16831868
    GO:0045121membrane raft TAS16831868

    CD226 for ontologies           About GeneDecksing



    CD226 Antibody Products: 
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    Novus Biologicals CD226 Antibodies
    Abcam antibodies for CD226
    Cloud-Clone Corp. Antibodies for CD226 
    ThermoFisher Antibodies for CD226
    LSBio Antibodies in human, mouse, rat for CD226 

    Assay Products for CD226: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for CD226 (DNAM-1/CD226)
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    Cloud-Clone Corp. ELISAs for CD226 
    Cloud-Clone Corp. CLIAs for CD226


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15762

    ProtoNet protein and cluster: Q15762

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: CD226_HUMAN, Q15762
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    CD226 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD226_HUMAN, Q15762
    Function: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion
    mediated by cytotoxic T-lymphocyte (CTL) and NK cell

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IPI16831868
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI16831868
    GO:0050839cell adhesion molecule binding IPI12913096
         
    CD226 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CD226:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd226):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    CD226 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD226: Cd226tm1.1Cln Cd226tm1Shib

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD226 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD226

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD226 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD226 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD226
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD226:
    hsa-miR-422a hsa-miR-378c hsa-miR-378 hsa-miR-4305 hsa-miR-331-3p hsa-miR-616* hsa-miR-373* hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidCD226 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD226
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD226

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD226
    Sirion Biotech Customized adenovirus for overexpression of CD226

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD226 (see all 7)
    OriGene ORF clones in mouse, rat for CD226
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD226 (NM_006566)
    Sino Biological Human cDNA Clone for CD226
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD226
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD226
    Sirion Biotech Customized lentivirus for stable overexpression of CD226 
                         Customized lentivirus expression plasmids for stable overexpression of CD226 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD226
    Search LifeMap BioReagents cell lines for CD226
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD226


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD226 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    3Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for CD226
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for CD226):
        Cell adhesion molecules (CAMs)


    CD226 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD226

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CD226 (Q157621, 3 ENSP000002802004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PVRL2Q926921, 3, ENSP000002524834EBI-4314442,EBI-718419 I2D: score=2 STRING: ENSP00000252483
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    PVRP151513, ENSP000004020604I2D: score=2 STRING: ENSP00000402060
    ITGALENSP000003492524STRING: ENSP00000349252
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP12913096
    GO:0002891positive regulation of immunoglobulin mediated immune response IDA16831868
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8673704

    CD226 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD226 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD226

    3 Novoseek inferred chemical compound relationships for CD226 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 7.99 6 10591186 (1), 14676297 (1), 15684041 (1)
    lipid 0 8 15684041 (4), 14676297 (1)
    serine 0 7 15684041 (2), 10591186 (1)

    Search CenterWatch for drugs/clinical trials and news about CD226

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD226 gene: 
    NM_006566.2  

    Unigene Cluster for CD226:

    CD226 molecule
    Hs.660130  [show with all ESTs]
    Unigene Representative Sequence: NM_006566
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578928 ENST00000581982 ENST00000280200(uc010dqo.3 uc002lkm.4 uc021uli.1)
    ENST00000577287 ENST00000582621 ENST00000579496 ENST00000583955 ENST00000580335

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD226
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD226:
    hsa-miR-422a hsa-miR-378c hsa-miR-378 hsa-miR-4305 hsa-miR-331-3p hsa-miR-616* hsa-miR-373* hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidCD226 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD226
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD226
    Clone
    Products:
         
    OriGene clones in human, mouse for CD226 (see all 7)
    OriGene ORF clones in mouse, rat for CD226
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD226 (NM_006566)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD226
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD226
    Sirion Biotech Customized lentivirus for stable overexpression of CD226 
                         Customized lentivirus expression plasmids for stable overexpression of CD226 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD226
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD226
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD226
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD226

    Additional mRNA sequence: 

    AJ537553.1 AK313199.1 BC074787.2 GU935335.1 GU935336.1 U56102.1 

    4 DOTS entries:

    DT.403912  DT.121085136  DT.121085079  DT.65284477 

    17 AceView cDNA sequences:

    AJ537553 BQ230257 AI160261 BC074787 BF939746 BX091594 AI361991 U56102 
    AI473683 AI424045 BG618646 CB962326 NM_006566 AI769771 BM918375 AA354883 
    AW950970 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD226    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:        -                             -                                 
    SP2:                                                                        
    SP3:                                      -                                 
    SP4:                                      -                                 


    ECgene alternative splicing isoforms for CD226

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD226 expression in normal human tissues (normalized intensities)      CD226 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAGAAGAG
    CD226 Expression
    About this image


    CD226 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Blood (Respiratory System)    fully expand to see all 2 entries
             lung ; macrophages   
             cord blood   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex

    See CD226 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD226

    SOURCE GeneReport for Unigene cluster: Hs.660130

    UniProtKB/Swiss-Prot: CD226_HUMAN, Q15762
    Tissue specificity: Expressed by peripheral blood T-lymphocytes

        SABiosciences Custom PCR Arrays for CD226
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD226
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD226

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD226 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2261 , 5 CD226 antigen1, 5 68.89(n)1
    54.55(a)1
      18 (59.05 cM)5
    2258251  NM_178687.21  NP_848802.21 
     891974315 
    chicken
    (Gallus gallus)
    Aves CD2261 CD226 molecule 53.59(n)
    36.71(a)
      772097  XM_001235284.1  XP_001235285.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD2266
    CD226 molecule
    25(a)
    1 ↔ 1
    4(46965241-46987095)
    zebrafish
    (Danio rerio)
    Actinopterygii cd2261 CD226 molecule 43.19(n)
    28.62(a)
      791164  NM_001080646.1  NP_001074115.1 


    ENSEMBL Gene Tree for CD226 (if available)
    TreeFam Gene Tree for CD226 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD226 gene
    1 SIMAP similar gene for CD226 using alignment to 6 protein entries:     CD226_HUMAN (see all proteins):
    PVRL3

    CD226 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2063 SNPs in CD226 are shown (see all 2063)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865307091,2
    --64345176(+) ATGGTA/GATAAA 1 -- us2k10--------
    rs798660701,2
    C,F--67529801(+) TTAAGC/TACAAC 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1471239471,2
    --67529819(+) TGGTCA/GTTTTT 1 -- ds50010--------
    rs1926335021,2
    --67529834(+) TTTCAC/TTCCTG 1 -- ds50010--------
    rs359771661,2
    C--67529965(+) AAAATACTC/-  
            
    ACTAA
    1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs2009569471,2
    C--67529968(+) ATACTA/CACTAA 1 -- ds50010--------
    rs1165503691,2
    C,F--67530097(+) AATGAA/GTCTTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs620907861,2
    C,F--67530195(+) CCTTTC/TAAGGT 1 -- ut314Minor allele frequency- T:0.06NA CSA WA 242
    rs2006363861,2
    C--67530205(+) TAACC-/TGACAG 1 -- ut310--------
    rs1857598231,2
    --67530227(+) TTTGGA/CAAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD226 (67498394 - 67629039 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD226:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717304CNV Deletion23290073
    nsv2347CNV Insertion18451855
    nsv909867CNV Gain21882294
    esv32736CNV Gain+Loss17666407


    Human Gene Mutation Database (HGMD): CD226
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605397    OMIM disorders: --

    20/31 diseases for CD226 (see all 31):    About MalaCards
    onchocerciasis    addison's disease    wegener's granulomatosis    vasculitis
    celiac disease    endotheliitis    brain injury    myelodysplastic syndromes
    herpes simplex    type 1 diabetes    systemic lupus erythematosus    multiple sclerosis
    psoriasis    myeloma    multiple myeloma    cervical cancer
    lupus erythematosus    lymphoblastic leukemia    rheumatoid arthritis    acute myeloid leukemia


    CD226 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CD226 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.06 16 19029379 (5), 19801517 (2), 15039383 (1), 19748980 (1) (see all 5)
    cancer 0 2 19748980 (1), 16015041 (1)

    Genetic Association Database (GAD): CD226
    Human Genome Epidemiology (HuGE) Navigator: CD226 (26 documents)

    Export disorders for CD226 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD226 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with CD226)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. (PubMed id 8673704)1, 2, 3 Shibuya A....Phillips J.H. (1996)
    2. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PubMed id 15039383)1, 2, 9 Tahara-Hanaoka S.... Shibuya A. (2004)
    3. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (2011)
    4. The CD226 Gly307Ser gene polymorphism is associated w ith severity of psoriasis. (PubMed id 20399620)1, 4 Douroudis K....KA/ks S. (2010)
    5. Non-synonymous variant (Gly307Ser) in CD226 is associ ated with susceptibility to multiple autoimmune diseases. (PubMed id 20338887)1, 4 Maiti A.K....Nath S.K. (2010)
    6. A 3'-untranslated region variant is associated with i mpaired expression of CD226 in T and natural killer T cells and is associated w ith susceptibility to systemic lupus erythematosus. (PubMed id 20669283)1, 4 LAPfgren S.E....Kozyrev S.V. (2010)
    7. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-t umour necrosis factor treatment. (PubMed id 20444755)1, 4 Tan R.J....Barton A. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    10. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. (PubMed id 20072139)1, 4 Hinks A....Thomson W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10666 HGNC: 16961 AceView: CD226 Ensembl:ENSG00000150637 euGenes: HUgn10666
    ECgene: CD226 Kegg: 10666 H-InvDB: CD226

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD226 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD226 gene:
    Search GeneIP for patents involving CD226

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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