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Aliases for CD226 Gene

Aliases for CD226 Gene

  • CD226 Molecule 2 3 5
  • CD226 Antigen 2 3 4
  • DNAM-1 3 4
  • DNAM1 3 4
  • T Lineage-Specific Activation Antigen 1 Antigen 3
  • Platelet And T Cell Activation Antigen 1 3
  • DNAX Accessory Molecule-1 3
  • DNAX Accessory Molecule 1 4
  • Adhesion Glycoprotein 3
  • TLiSA1 3
  • PTA1 3

External Ids for CD226 Gene

Previous GeneCards Identifiers for CD226 Gene

  • GC18M067315
  • GC18M065679
  • GC18M065681
  • GC18M067528
  • GC18M064248

Summaries for CD226 Gene

Entrez Gene Summary for CD226 Gene

  • This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CD226 Gene

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Ovarian Cystic Teratoma and Mature Teratoma Of The Ovary. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Cell adhesion molecules (CAMs). GO annotations related to this gene include protein kinase binding and cell adhesion molecule binding.

UniProtKB/Swiss-Prot for CD226 Gene

  • Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

Gene Wiki entry for CD226 Gene

Additional gene information for CD226 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD226 Gene

Genomics for CD226 Gene

Regulatory Elements for CD226 Gene

Enhancers for CD226 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H069885 1.1 FANTOM5 ENCODE 17.4 +75.8 75845 0 HDGF SOX13 PKNOX1 BACH1 BMI1 BATF RELA POLR2A ATF7 IKZF2 CD226 RTTN GC18M069851
GH18H069934 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 +25.5 25466 3 ELF3 PKNOX1 BMI1 BATF ATF7 ETV6 RUNX3 CREM IKZF2 EGR2 CD226 RTTN GC18M069851
GH18H069894 1.4 Ensembl ENCODE dbSUPER 8.4 +65.0 65010 4 HDGF PKNOX1 BMI1 YBX1 BATF ATF7 RUNX3 CREM IKZF2 CBFB CD226 DOK6 GC18M069851
GH18H069940 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +16.6 16634 8 PKNOX1 ATF1 TBL1XR1 ZSCAN4 ZNF133 BMI1 BATF ZNF143 ATF7 ETV6 CD226 GC18M069851
GH18H069955 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +4.1 4142 4 CTCF PKNOX1 BACH1 BATF RELA POLR2A SMC3 ETV6 RUNX3 IKZF2 CD226 SOCS6 GC18M069851
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD226 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD226 Gene

Chromosome:
18
Start:
69,831,158 bp from pter
End:
69,961,803 bp from pter
Size:
130,646 bases
Orientation:
Minus strand

Genomic View for CD226 Gene

Genes around CD226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD226 Gene

Proteins for CD226 Gene

  • Protein details for CD226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15762-CD226_HUMAN
    Recommended name:
    CD226 antigen
    Protein Accession:
    Q15762
    Secondary Accessions:
    • B2R818

    Protein attributes for CD226 Gene

    Size:
    336 amino acids
    Molecular mass:
    38614 Da
    Quaternary structure:
    • Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.

neXtProt entry for CD226 Gene

Post-translational modifications for CD226 Gene

  • Ubiquitination at posLast=295295
  • Glycosylation at Asn32, posLast=8383, Asn90, posLast=9797, posLast=147147, posLast=186186, Asn198, and Asn231
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CD226 Gene

Domains & Families for CD226 Gene

Gene Families for CD226 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD226 Gene

Suggested Antigen Peptide Sequences for CD226 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD226: view

No data available for UniProtKB/Swiss-Prot for CD226 Gene

Function for CD226 Gene

Molecular function for CD226 Gene

UniProtKB/Swiss-Prot Function:
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

Phenotypes From GWAS Catalog for CD226 Gene

Gene Ontology (GO) - Molecular Function for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005178 integrin binding IPI 16831868
GO:0005515 protein binding IPI 21982860
GO:0019901 protein kinase binding IPI 16831868
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with CD226: view
genes like me logo Genes that share phenotypes with CD226: view

Animal Models for CD226 Gene

MGI Knock Outs for CD226:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD226

CRISPR Products

miRNA for CD226 Gene

miRTarBase miRNAs that target CD226

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD226
  • Applied Biological Materials Clones for CD226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD226 Gene

Localization for CD226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD226 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD226 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8673704
GO:0005913 cell-cell adherens junction IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 16831868
genes like me logo Genes that share ontologies with CD226: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD226 Gene

Pathways & Interactions for CD226 Gene

genes like me logo Genes that share pathways with CD226: view

Gene Ontology (GO) - Biological Process for CD226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0002729 positive regulation of natural killer cell cytokine production IEA --
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IDA 16831868
GO:0007155 cell adhesion TAS 8673704
genes like me logo Genes that share ontologies with CD226: view

No data available for SIGNOR curated interactions for CD226 Gene

Drugs & Compounds for CD226 Gene

(2) Drugs for CD226 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CD226 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD226: view

Transcripts for CD226 Gene

Unigene Clusters for CD226 Gene

CD226 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD226
  • Applied Biological Materials Clones for CD226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD226 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for CD226 Gene

GeneLoc Exon Structure for
CD226
ECgene alternative splicing isoforms for
CD226

Expression for CD226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD226 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.4), Platelet (25.2), and Monocytes (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD226 Gene



Protein tissue co-expression partners for CD226 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD226 Gene:

CD226

SOURCE GeneReport for Unigene cluster for CD226 Gene:

Hs.660130

mRNA Expression by UniProt/SwissProt for CD226 Gene:

Q15762-CD226_HUMAN
Tissue specificity: Expressed by peripheral blood T-lymphocytes.

Evidence on tissue expression from TISSUES for CD226 Gene

  • Blood(4.6)
  • Nervous system(4.1)
  • Spleen(2.4)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CD226: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD226 Gene

Orthologs for CD226 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD226 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD226 33 34
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia CD226 33 34
  • 77.17 (n)
cow
(Bos Taurus)
Mammalia CD226 33 34
  • 72.89 (n)
mouse
(Mus musculus)
Mammalia Cd226 33 16 34
  • 68.89 (n)
rat
(Rattus norvegicus)
Mammalia Cd226 33
  • 68.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CD226 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD226 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD226 33 34
  • 50.99 (n)
lizard
(Anolis carolinensis)
Reptilia CD226 34
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd226 33 34
  • 43.7 (n)
Species where no ortholog for CD226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD226 Gene

ENSEMBL:
Gene Tree for CD226 (if available)
TreeFam:
Gene Tree for CD226 (if available)

Paralogs for CD226 Gene

(1) SIMAP similar genes for CD226 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD226: view

No data available for Paralogs for CD226 Gene

Variants for CD226 Gene

Sequence variations from dbSNP and Humsavar for CD226 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000004508 -- 69,925,740(+) ATGAA(C/T)GACAG intron-variant
rs1000028958 -- 69,958,889(+) TTATT(C/T)AGCTA intron-variant, upstream-variant-2KB
rs1000046211 -- 69,925,595(+) CTGGA(C/T)CCCGT intron-variant
rs1000047751 -- 69,919,561(+) AGGCA(-/AGG)AGATT intron-variant
rs1000048186 -- 69,946,460(+) GCTCA(C/G)GTTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD226 Gene

Variant ID Type Subtype PubMed ID
dgv1922e59 CNV duplication 20981092
dgv632e214 CNV loss 21293372
esv2717304 CNV deletion 23290073
esv32736 CNV gain+loss 17666407
esv3893135 CNV loss 25118596
esv3893136 CNV loss 25118596
nsv2347 CNV insertion 18451855

Variation tolerance for CD226 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD226 Gene

Human Gene Mutation Database (HGMD)
CD226
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD226 Gene

Disorders for CD226 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD226 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cystic teratoma
mature teratoma of the ovary
  • mature teratoma of ovary
refractory celiac disease
  • refractory cd
lymphoproliferative syndrome, x-linked, 1
  • x-linked lymphoproliferative syndrome 1
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search CD226 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD226

Genetic Association Database (GAD)
CD226
Human Genome Epidemiology (HuGE) Navigator
CD226
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD226
genes like me logo Genes that share disorders with CD226: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD226 Gene

Publications for CD226 Gene

  1. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PMID: 15039383) Tahara-Hanaoka S … Shibuya A (International immunology 2004) 3 4 22 60
  2. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. (PMID: 8673704) Shibuya A … Phillips JH (Immunity 1996) 2 3 4 60
  3. Identification of CD112R as a novel checkpoint for human T cells. (PMID: 26755705) Zhu Y … Edil BH (The Journal of experimental medicine 2016) 3 4 60
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 45 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for CD226 Gene

  • Addgene plasmids for CD226

Sources for CD226 Gene

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