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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD22 Gene

protein-coding   GIFtS: 67
GCID: GC19P035826

CD22 Molecule

(Previous name: CD22 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD22 Molecule1 2     B-Lymphocyte Cell Adhesion Molecule2 3
CD22 Antigen1 2 3     T-Cell Surface Antigen Leu-142 3
Sialic Acid Binding Ig-Like Lectin 21 2     SIGLEC-22
Sialic Acid-Binding Ig-Like Lectin 22 3     B-Cell Receptor CD222
BL-CAM2 3     Siglec-23
SIGLEC22 3     

External Ids:    HGNC: 16431   Entrez Gene: 9332   Ensembl: ENSG000000121247   OMIM: 1072665   UniProtKB: P202733   

Export aliases for CD22 gene to outside databases

Previous GC identifers: GC19U990008 GC19P036269 GC19P040498 GC19P040511 GC19P035820 GC19P032328


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CD22 Gene: 
CD22 (CD22 molecule) is a protein-coding gene. Diseases associated with CD22 include eaf, and lymphosarcoma, and among its related super-pathways are BCR signaling pathway and Immune response Fc epsilon RI pathway. GO annotations related to this gene include protein binding. An important paralog of this gene is VCAM1.

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.
Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The
sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon
ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell
antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine
kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains
that block signal transduction through dephosphorylation of signaling molecules

Gene Wiki entry for CD22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD22 gene promoter:
         Sp1   AP-2alpha isoform 3   Egr-1   AP-4   AP-2alpha isoform 2   LCR-F1   AREB6   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

CD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD22 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035826:  view genomic region     (about GC identifiers)

Start:
35,810,164 bp from pter      End:
35,838,264 bp from pter
Size:
28,101 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273 (See protein sequence)
Recommended Name: B-cell receptor CD22 precursor  
Size: 847 amino acids; 95348 Da
Subunit: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter
isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2,
INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA36988.1; Type=Frameshift; Positions=806;
Secondary accessions: F5GYU4 F5H7U3 O95699 O95701 O95702 O95703 Q01665 Q92872 Q92873 Q9UQA6
Q9UQA7 Q9UQA8 Q9UQA9 Q9UQB0 Q9Y2A6
Alternative splicing: 4 isoforms:  P20273-1   P20273-2   P20273-3   P20273-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CD22: NX_P20273

Explore proteomics data for CD22 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively.
    Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2
  • UniProtKB: Phosphorylated on tyrosine residues by LYN (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20273

  • CD22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD22 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001172028.1  NP_001172029.1  NP_001172030.1  NP_001265346.1  NP_001762.2  

    ENSEMBL proteins: 
     ENSP00000469980   ENSP00000470681   ENSP00000469503   ENSP00000472664   ENSP00000472762  
     ENSP00000471972   ENSP00000471399   ENSP00000469523   ENSP00000470193   ENSP00000442279  
     ENSP00000085219   ENSP00000441237   ENSP00000403822   ENSP00000469984   ENSP00000470724  
     ENSP00000473221   ENSP00000339349   ENSP00000270311  

    Human Recombinant Protein Products for CD22: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD22 (Siglec-2/CD22)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD22
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CD22 
    OriGene Custom Protein Services for CD22
    GenScript Custom Purified and Recombinant Proteins Services for CD22
    Sino Biological Recombinant Protein for CD22
    Sino Biological Cell Lysate for CD22 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    CD22 for ontologies           About GeneDecksing



    CD22 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD22
    R&D Systems Antibodies for CD22 (Siglec-2/CD22)
    OriGene Antibodies for CD22
    OriGene Custom Antibody Services for CD22
    GenScript Custom Superior Antibodies Services for CD22
    Novus Biologicals CD22 Antibodies
    Abcam antibodies for CD22
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD22
    LSBio Antibodies in human, mouse, rat for CD22 

    Assay Products for CD22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD22
    R&D Systems Proteome Profiler Antibody Arrays for CD22 (Siglec-2/CD22)
    GenScript Custom Assay Services for CD22
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P20273

    ProtoNet protein and cluster: P20273

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
    Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD22_HUMAN, P20273
    Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.
    Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The
    sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon
    ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell
    antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine
    kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains
    that block signal transduction through dephosphorylation of signaling molecules

         Genatlas biochemistry entry for CD22:
    cell differentiation antigen CD22,glycoprotein,identified by monoclonal antibodies HD39,S-HCL1,TO15,specifically
    expressed in B cells,involved in the regulation of B cell activation sialoadhesin,Ig superfamily,potential
    susceptibility gene for autoimmune diseases

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI8627166
         
    CD22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD22:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Cd22):
     cellular  hematopoietic system  immune system  mortality/aging 

    CD22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD22: Cd22tm3Tft Cd22tm1Tft Cd22tm1Lam Cd22tm1Msn Cd22tm1Eac

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD22 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD22 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD22
    SwitchGear 3'UTR luciferase reporter plasmidCD22 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD22
    Sirion Biotech Customized adenovirus for overexpression of CD22

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD22 (see all 12)
    OriGene ORF clones in mouse, rat for CD22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22
    Sirion Biotech Customized lentivirus for stable overexpression of CD22 
                         Customized lentivirus expression plasmids for stable overexpression of CD22 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD22
    Search LifeMap BioReagents cell lines for CD22
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD22 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.45
    3Hematopoietic cell lineage
    Hematopoietic cell lineage
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    5B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CD22
        Immune response BCR pathway


    1 GeneGo (Thomson Reuters) Pathway for CD22
        Immune response BCR pathway

    2 BioSystems Pathways for CD22
        B Cell Receptor Signaling Pathway
    BCR signaling pathway



    3         Kegg Pathways  (Kegg details for CD22):
        Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage
    B cell receptor signaling pathway


    CD22 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/29 Interacting proteins for CD22 (P202731, 2, 3 ENSP000000852194) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 3, ENSP000002440074EBI-78277,EBI-79387 I2D: score=5 STRING: ENSP00000244007
    SYKP434051, 3, ENSP000003648984EBI-78277,EBI-78302 I2D: score=5 STRING: ENSP00000364898
    LYNP079481, 3EBI-78277,EBI-79452 I2D: score=3 
    PTPN6P293501, 3, ENSP000003915924EBI-78277,EBI-78260 I2D: score=5 STRING: ENSP00000391592
    PTPRCP085752, 3, ENSP000003563464MINT-8312050 I2D: score=3 STRING: ENSP00000356346
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    CD22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD22 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD22

    5 Novoseek inferred chemical compound relationships for CD22 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epratuzumab 80 3 14503946 (1), 20297867 (1), 11842393 (1)
    sialic acid 63.5 10 7706300 (4), 8702538 (1), 16408005 (1), 11994426 (1) (see all 5)
    tyrosine 35.7 18 10228003 (4), 16782884 (2), 8647200 (2), 8627166 (1) (see all 7)
    polysaccharide 25.6 6 16408005 (4), 12429811 (1)
    oligonucleotide 0 1 12855573 (1)

    Search CenterWatch for drugs/clinical trials and news about CD22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD22 gene (6 alternative transcripts): 
    NM_024916.1  NM_001185099.1  NM_001185100.1  NM_001185101.1  NM_001278417.1  NM_001771.3  

    Unigene Cluster for CD22:

    CD22 molecule
    Hs.579691  [show with all ESTs]
    Unigene Representative Sequence: NM_001771
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000598537 ENST00000601414 ENST00000595419 ENST00000599717 ENST00000600131
    ENST00000598138 ENST00000599799 ENST00000595780 ENST00000602224 ENST00000597916
    ENST00000596492 ENST00000600905 ENST00000593867 ENST00000601732 ENST00000598028
    ENST00000600424 ENST00000599811 ENST00000598815
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD22
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD22
    SwitchGear 3'UTR luciferase reporter plasmidCD22 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD22
    Clone
    Products:
         
    OriGene clones in human, mouse for CD22 (see all 12)
    OriGene ORF clones in mouse, rat for CD22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22
    Sirion Biotech Customized lentivirus for stable overexpression of CD22 
                         Customized lentivirus expression plasmids for stable overexpression of CD22 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD22
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD22

    Additional mRNA sequence: 

    AK225625.1 AK225694.1 AK301177.1 BC109306.1 BC109307.1 X52785.1 X59350.1 

    21 DOTS entries:

    DT.452306  DT.121497025  DT.91767061  DT.121497010  DT.100775960  DT.121497018  DT.100775963  DT.121497015 
    DT.95103604  DT.121497029  DT.91767067  DT.95128281  DT.121497027  DT.121497003  DT.121497050  DT.100775956 
    DT.101980011  DT.121497016  DT.95103602  DT.95103603  DT.121497005 

    24/286 AceView cDNA sequences (see all 286):

    F09020 BQ632310 BQ057104 BX350637 BM478063 BQ055266 CD514856 NM_080600 
    BC053347 BU192138 AW337790 BF111811 CR614873 F04235 BG176660 BG685870 
    BE874674 AI859588 BQ055275 BX280770 BE267684 BM475659 BM702139 AW408631 

    GeneLoc Exon Structure

    5/28 Alternative Splicing Database (ASD) splice patterns (SP) for CD22 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
    SP1:                                                                                      -                                                                     
    SP2:                                                                                      -     -     -                                                         
    SP3:                                                                                      -                                               -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:  -     -                                                                                 
    SP4:                                            -                                             
    SP5:  -     -                                   -                                             


    ECgene alternative splicing isoforms for CD22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD22 expression in normal human tissues (normalized intensities)      CD22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACCTCCC
    CD22 Expression
    About this image


    CD22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Spleen (Hematopoietic System)    fully expand to see all 3 entries
             Conventional Dendritic Cells II Spleen
             spleen ; cells in white pulp   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; germinal center cells   
             LYMPH NODE   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose

    See CD22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD22

    SOURCE GeneReport for Unigene cluster: Hs.579691

    UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
    Tissue specificity: B-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD22: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD22 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd221 , 5 CD22 antigen1, 5 70.41(n)1
    62.08(a)1
      7 (19.26 cM)5
    124831  NM_001043317.21  NP_001036782.11 
     308654045 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    27(a)
    19(a)
    many → 1
    many → 1
    GL343281.1(335557-362900)
    GL343281.1(315271-325380)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-24p1.11 si:dkey-24p1.1 41.85(n)
    29.05(a)
      556718  NM_001098245.1  NP_001091715.1 


    ENSEMBL Gene Tree for CD22 (if available)
    TreeFam Gene Tree for CD22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD22 gene
    VCAM12  SIGLEC12  
    3 SIMAP similar genes for CD22 using alignment to 19 protein entries:     CD22_HUMAN (see all proteins):
    PSG11    CEA    FCGR2B

    CD22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/558 SNPs in CD22 are shown (see all 558)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0039134
    ----see VAR_0039132 Q E mis40--------
    VAR_0039154
    ----see VAR_0039152 R C mis40--------
    VAR_0141344
    ----see VAR_0141342 E K mis40--------
    rs1856326241,2
    --35818138(+) TGGGAC/TTTTTT 4 -- us2k10--------
    rs768110961,2
    C,F--35818293(+) AGTCTT/CCTTAT 4 -- us2k11Minor allele frequency- C:0.06EA 120
    rs1396437221,2
    --35818301(+) TATGCG/TTGTCT 4 -- us2k10--------
    rs1499395731,2
    C--35818313(+) GTCACA/GTTCAA 4 -- us2k10--------
    rs770343241,2
    C,F--35818595(+) AGCCCC/TACAGA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs9289371,2
    C,F,A,H--35818609(+) ttgctA/Gtgttg 4 -- us2k127Minor allele frequency- G:0.41NS EA NA WA CSA 2772
    rs9289381,2
    C,F,A,H--35818685(+) caggcG/Ataagt 4 -- us2k1 tfbs325Minor allele frequency- A:0.14NS EA NA WA CSA 2319

    HapMap Linkage Disequilibrium report for CD22 (35810164 - 35838264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD22:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2471CNV Loss18451855
    nsv510765CNV Loss20534489
    nsv173CNV Loss15895083
    nsv833810CNV Gain17160897
    dgv1080e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CD22
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107266    OMIM disorders: --

    20/26 diseases for CD22 (see all 26):    About MalaCards
    eaf    lymphosarcoma    bullous pemphigoid    parathyroid adenoma
    acute leukemia    hairy cell leukemia    b-cell chronic lymphocytic leukemia    lymphoblastic leukemia
    acute lymphoblastic leukemia    non-hodgkin lymphoma    chronic lymphocytic leukemia    hodgkin's lymphoma
    systemic lupus erythematosus    b-cell lymphomas    adenoma    leukemia
    lupus erythematosus    t-cell leukemia    hepatitis b    colon cancer

    3 diseases from the University of Copenhagen DISEASES database for CD22:
    Lymphoma     Leukemia     Systemic lupus erythematosus

    CD22 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for CD22 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 50.5 1 8501986 (1)
    acute leukemia 40.4 1 8501986 (1)
    lymphoma 33.1 4 7706300 (3), 11728231 (1)
    lymphoma b-cell 25.7 1 20122924 (1)
    tumors 3.68 4 7860060 (1), 7706300 (1), 12429643 (1)
    autoimmune diseases 0 1 16782884 (1)
    necrosis 0 2 7706300 (1)
    cancer 0 2 18474217 (1)

    Genetic Association Database (GAD): CD22
    Human Genome Epidemiology (HuGE) Navigator: CD22 (8 documents)

    Export disorders for CD22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD22 gene, integrated from 9 sources (see all 130):
    (articles sorted by number of sources associating them with CD22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. (PubMed id 1691828)1, 2, 3, 9 Stamenkovic I. and Seed B. (1990)
    2. Identification of the gene variations in human CD22. (PubMed id 10079291)1, 2, 4 Hatta Y....Tokunaga K. (1999)
    3. Genomic structure and chromosomal mapping of the human CD22 gene. (PubMed id 8496602)1, 2, 3 Wilson G.L.... Kehrl J.H. (1993)
    4. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (PubMed id 8627166)1, 2, 9 Law C.L.... Clark E.A. (1996)
    5. Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. (PubMed id 8647200)1, 2, 9 Tuscano J.M.... Kehrl J.H. (1996)
    6. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (2008)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. (PubMed id 17493148)1, 4 Hitomi Y.... Sato S. (2007)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    10. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. (PubMed id 9143697)1, 2 Tedder T.F.... Kehrl J.H. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 933 HGNC: 1643 AceView: CD22andMAG Ensembl:ENSG00000012124 euGenes: HUgn933
    ECgene: CD22 Kegg: 933 H-InvDB: CD22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD22 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00001
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_269

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD22 gene:
    Search GeneIP for patents involving CD22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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