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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD22 Gene

protein-coding GIFtS: 68
GCID: GC19P035820

CD22 molecule

(Previous name: CD22 antigen )

Explore 23 diseases affiliated with
CD22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD22 Molecule¹ ²		B-Lymphocyte Cell Adhesion Molecule² ³
SIGLEC2¹ ² ³		T-Cell Surface Antigen Leu-14² ³
CD22 Antigen¹ ² ³		B-Cell Receptor CD22²
SIGLEC-2¹ ²		Sialic Acid Binding Ig-Like Lectin 2²
Sialic Acid-Binding Ig-Like Lectin 2² ³		Siglec-2³
BL-CAM² ³

External Ids:	HGNC: 1643¹	Entrez Gene: 933²	Ensembl: ENSG00000012124⁷	OMIM: 107266⁵	UniProtKB: P20273³

Export aliases for CD22 gene to outside databases

Previous GC identifers: GC19U990008 GC19P036269 GC19P040498 GC19P040511 GC19P032328

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273

Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.

Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic

acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand

induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor

signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act

as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction

through dephosphorylation of signaling molecules

Gene Wiki entry for CD22

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD22 gene promoter:
Sp1 AP-2alpha isoform 3 Egr-1 AP-4 AP-2alpha isoform 2 LCR-F1 AREB6 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD22 promoter sequence

Search SABiosciences Chromatin IP Primers for CD22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1

CD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD22 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P035820: view genomic region (about GC identifiers)

Start:	35,820,072 bp from pter	End:	35,838,264 bp from pter
Size:	18,193 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273 (See protein sequence)

Recommended Name: B-cell receptor CD22 precursor

Size: 847 amino acids; 95348 Da

Subunit: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter

isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2,

INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Sequence caution: Sequence=CAA36988.1; Type=Frameshift; Positions=806;

Secondary accessions: F5H7U3 O95699 O95701 O95702 O95703 Q01665 Q92872 Q92873 Q9UQA6 Q9UQA7 Q9UQA8

Q9UQA9 Q9UQB0 Q9Y2A6

Alternative splicing: 3 isoforms: P20273-1 P20273-2 P20273-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD22: NX_P20273

Post-translational modifications:

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively.

Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2¹

Phosphorylated on tyrosine residues by LYN (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20273

CD22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001172028.1 NP_001172029.1 NP_001172030.1 NP_001762.2

ENSEMBL proteins:

ENSP00000085219 ENSP00000442279 ENSP00000339349 ENSP00000441237 ENSP00000270311

ENSP00000403822

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD22 (Siglec-2/CD22)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD22 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CD22
	GenScript Custom Purified and Recombinant Proteins Services for CD22
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD22

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016020	membrane	--	--

CD22 for ontologies About GeneDecksing

CD22 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD22
	R&D Systems Antibodies for CD22 (Siglec-2/CD22)
	OriGene Antibodies (see all 7): CD22 OriGene Custom Antibody Services for CD22
	GenScript Custom Superior Antibodies Services for CD22
	Novus Biologicals CD22 Antibodies
	Abcam antibodies for CD22
	Uscn Antibodies for CD22
	ThermoFisher Antibody for CD22

Assay Products for CD22:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD22 (Siglec-2/CD22)
	GenScript Custom Assay Services for CD22
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD22

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD22 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR013162 CD80_C2-set

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P20273

ProtoNet protein and cluster: P20273

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013162 CD80-like C2-set immunoglobulin

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273

Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor

motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the

SH2 domain of several SH2-containing phosphatases

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family

Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273

Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.

Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic

acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand

induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor

signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act

as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction

through dephosphorylation of signaling molecules

Genatlas biochemistry entry for CD22:

cell differentiation antigen CD22,glycoprotein,identified by monoclonal antibodies HD39,S-HCL1,TO15,specifically

expressed in B cells,involved in the regulation of B cell activation sialoadhesin,Ig superfamily,potential

susceptibility gene for autoimmune diseases

miRNA Products:		OriGene 3'-UTR Clone: CD22 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD22
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD22
		SwitchGear 3'UTR luciferase reporter plasmid: CD22 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD22 (see all 7) OriGene shRNA RFP: CD22 OriGene siRNA: CD22
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD22

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD22

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD22 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD22 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD22
		Search LifeMap BioReagents cell lines for CD22

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD22

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	8647200
GO:0030246	carbohydrate binding	--	--

CD22 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD22:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for CD22: Cd22^tm3Tft Cd22^tm1Tft Cd22^tm1Lam Cd22^tm1Msn Cd22^tm1Eac
4 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Cd22):

cellular

hematopoietic system

immune system

mortality/aging

CD22 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response BCR pathway

Immune response BCR pathway

1.00

Immune response_BCR pathway

0.99

B cell receptor signaling pathway

B cell receptor signaling pathway

1.00

BCR signaling pathway

0.41

B Cell Receptor Signaling Pathway

B Cell Receptor Signaling Pathway

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CD22

Immune response BCR pathway

1 GeneGo (Thomson Reuters) Pathway for CD22

Immune response BCR pathway

2 BioSystems Pathways for CD22

	B Cell Receptor Signaling Pathway
	BCR signaling pathway

3 Kegg Pathways (Kegg details for CD22):

	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage
	B cell receptor signaling pathway

CD22 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD22

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/29 Interacting proteins for CD22 (P20273^{1, 2, 3} ENSP00000085219⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCG1	P19174¹^,³, ENSP00000244007⁴	EBI-78277,EBI-79387 I2D: score=5 STRING: ENSP00000244007
SYK	P43405¹^,³, ENSP00000364898⁴	EBI-78277,EBI-78302 I2D: score=5 STRING: ENSP00000364898
LYN	P07948¹^,³	EBI-78277,EBI-79452 I2D: score=3
PTPN6	P29350¹^,³, ENSP00000391592⁴	EBI-78277,EBI-78260 I2D: score=5 STRING: ENSP00000391592
PTPRC	P08575²^,³, ENSP00000356346⁴	MINT-8312050 I2D: score=3 STRING: ENSP00000356346

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

CD22 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD22 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD22
5 Novoseek chemical compound relationships for CD22 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epratuzumab	80	3	14503946 (1), 20297867 (1), 11842393 (1)
sialic acid	63.5	10	7706300 (4), 8702538 (1), 16408005 (1), 11994426 (1) (see all 5)
tyrosine	35.7	18	10228003 (4), 16782884 (2), 8647200 (2), 8627166 (1) (see all 7)
polysaccharide	25.6	6	16408005 (4), 12429811 (1)
oligonucleotide	0	1	12855573 (1)

Search CenterWatch for drugs/clinical trials and news about CD22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD22 gene (5 alternative transcripts):

NM_024916.1 NM_001185099.1 NM_001185100.1 NM_001185101.1 NM_001771.3

Unigene Cluster for CD22:

CD22 molecule

Hs.579691 [show with all ESTs]

Unigene Representative Sequence: NM_001771

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000085219(uc010edt.3 uc010xst.2 uc010edx.3) ENST00000536635(uc010edu.3)

ENST00000341773(uc002nzb.4) ENST00000544992(uc010edv.3) ENST00000270311

ENST00000419549

miRNA Products:		OriGene 3'-UTR Clone: CD22 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD22
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD22
		SwitchGear 3'UTR luciferase reporter plasmid: CD22 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD22 (see all 7) OriGene shRNA RFP: CD22 OriGene siRNA: CD22
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD22

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD22 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD22 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD22 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD22
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD22
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD22

Additional cDNA sequence:

AK225625.1 AK225694.1 AK301177.1 BC109306.1 BC109307.1 X52785.1 X59350.1

21 DOTS entries:

DT.452306 DT.121497025 DT.91767061 DT.121497010 DT.100775960 DT.121497018 DT.100775963 DT.121497015

DT.95103604 DT.121497029 DT.91767067 DT.95128281 DT.121497027 DT.121497003 DT.121497050 DT.100775956

DT.101980011 DT.121497016 DT.95103602 DT.95103603 DT.121497005

24/286 AceView cDNA sequences (see all 286):

BQ057725 BQ055266 BC053347 CD514856 F04235 T27881 X52785 BM475659

BQ057104 AW408631 CR614873 AW500201 AW337790 BE874674 BX350637 AI859588

BQ632310 BM478063 BX280770 BM702139 BG176660 BE267684 BG685870 BQ059060

GeneLoc Exon Structure

5/28 Alternative Splicing Database (ASD) splice patterns (SP) for CD22 (see all 28) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·
SP1:																													-
SP2:																													-		-		-
SP3:																													-																-		-		-		-
SP4:
SP5:							-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	12b	·	12c	^	13a	·	13b	·	13c	·	13d	·	13e	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20
SP1:
SP2:
SP3:	-		-
SP4:															-
SP5:	-		-												-

ECgene alternative splicing isoforms for CD22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACCTCCC

About this image

CD22 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD22

SOURCE GeneReport for Unigene cluster: Hs.579691

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273

Tissue specificity: B-lymphocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including CD22:

Cell Surface Markers in human mouse rat

Lymphoma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD22 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD22

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD22

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD22 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CD22⁶	--	29(a)	1 ↔ 1	GL343281.1(341011-350648)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-24p1.1¹	si:dkey-24p1.1	41.85(n) 29.05(a)		556718 NM_001098245.1 NP_001091715.1

ENSEMBL Gene Tree for CD22 (if available)
TreeFam Gene Tree for CD22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD22 gene

SIGLEC1²

3 SIMAP similar genes for CD22 using alignment to 20 protein entries: CD22_HUMAN (see all proteins):

PSG11 CEA FCGR2B

CD22 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185632624^1,2		--	35818138(+)	`TGGGAC/TTTTTT`	4	--	us2k¹		0	--	--	--	--
rs76811096^1,2	F,	--	35818293(+)	`AGTCTT/CCTTAT`	4	--	us2k¹		1		EA	120
rs139643722^1,2		--	35818301(+)	`TATGCG/TTGTCT`	4	--	us2k¹		0	--	--	--	--
rs149939573^1,2	C,	--	35818313(+)	`GTCACA/GTTCAA`	4	--	us2k¹		0	--	--	--	--
rs77034324^1,2	F,	--	35818595(+)	`AGCCCC/TACAGA`	4	--	us2k¹		1		WA	118
rs928937^1,2	C,F,A,H,	--	35818609(+)	`TTGCTA/GTGTTG`	4	--	us2k¹		27		NS EA NA WA CSA	2772
rs928938^1,2	C,F,A,H,	--	35818685(+)	`CAGGCG/ATAAGT`	4	--	us2k¹ tfbs³		25		NS EA NA WA CSA	2319
rs144132136^1,2		--	35818760(+)	`CTATGG/TCCAGC`	4	--	us2k¹		0	--	--	--	--
rs17719240^1,2	C,F,H,	--	35818831(+)	`AGGATG/ATGCAT`	4	--	us2k¹		8		NA NS EA	678
rs148702323^1,2		--	35818842(+)	`GGCTTA/CCAATG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD22 (35820072 - 35838264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CD22
3 CNVs: 4078 35637 0511
Human Gene Mutation Database (HGMD): CD22

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD22

DNA2.0 Custom Variant and Variant Library Synthesis for CD22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD22 for disorders           About GeneDecksing

OMIM gene information: 107266    OMIM disorders: --

20/23 diseases for CD22 (see all 23):    About MalaCards

non-hodgkin lymphoma bullous pemphigoid b-cell lymphomas parathyroid adenoma

lymphoblastic leukemia systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma

lymphosarcoma acute lymphoblastic leukemia chronic lymphocytic leukemia eaf

lymphocytic leukemia acute leukemia leukemia rheumatoid arthritis

hepatitis b adenoma hepatocellular carcinoma colon cancer

2 diseases from the University of Copenhagen DISEASES database for CD22:

Lymphoma Leukemia

8 Novoseek disease relationships for CD22 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	50.5	1	8501986 (1)
acute leukemia	40.4	1	8501986 (1)
lymphoma	33.1	4	7706300 (3), 11728231 (1)
lymphoma b-cell	25.7	1	20122924 (1)
tumors	3.68	4	7860060 (1), 7706300 (1), 12429643 (1)
autoimmune diseases	0	1	16782884 (1)
necrosis	0	2	7706300 (1)
cancer	0	2	18474217 (1)

Genetic Association Database (GAD): CD22
Human Genome Epidemiology (HuGE) Navigator: CD22 (8 documents)

Export disorders for CD22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD22 gene, integrated from 9 sources (see all 127):
(articles sorted by number of sources associating them with CD22)

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world of online information

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. (PubMed id 1691828)^{1, 2, 3, 9} Stamenkovic I. and Seed B. (1990)
Identification of the gene variations in human CD22. (PubMed id 10079291)^{1, 2, 4} Hatta Y....Tokunaga K. (1999)
Genomic structure and chromosomal mapping of the human CD22 gene. (PubMed id 8496602)^{1, 2, 3} Wilson G.L.... Kehrl J.H. (1993)
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (PubMed id 8627166)^{1, 2, 9} Law C.L.... Clark E.A. (1996)
Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. (PubMed id 8647200)^{1, 2, 9} Tuscano J.M.... Kehrl J.H. (1996)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. (PubMed id 9143697)^{1, 2} Tedder T.F.... Kehrl J.H. (1997)
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. (PubMed id 7618087)^{1, 2} Doody G.M.... Fearon D.T. (1995)
Natural ligands of the B cell adhesion molecule CD22 beta carry N- linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition. (PubMed id 8463235)^{1, 2} Powell L.D.... Varki A. (1993)
cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. (PubMed id 1985119)^{1, 2} Wilson G.L.... Kehrl J.H. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 933	HGNC: 1643	AceView: CD22andMAG	Ensembl:ENSG00000012124	euGenes: HUgn933
ECgene: CD22	Kegg: 933	H-InvDB: CD22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD22	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD22	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00001
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_269

Intellectual Property for CD22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD22 gene:
Search GeneIP for patents involving CD22

GeneCards and IP:
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