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CD22 Gene

protein-coding   GIFtS: 68
GCID: GC19P035957

CD22 Molecule

(Previous name: CD22 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD22 Molecule1 2     B-Lymphocyte Cell Adhesion Molecule2 3
CD22 Antigen1 2 3     T-Cell Surface Antigen Leu-142 3
Sialic Acid Binding Ig-Like Lectin 21 2     SIGLEC-22
Sialic Acid-Binding Ig-Like Lectin 22 3     B-Cell Receptor CD222
BL-CAM2 3     Siglec-23
SIGLEC22 3     

External Ids:    HGNC: 16431   Entrez Gene: 9332   Ensembl: ENSG000000121247   OMIM: 1072665   UniProtKB: P202733   

Export aliases for CD22 gene to outside databases

Previous GC identifers: GC19U990008 GC19P036269 GC19P040498 GC19P040511 GC19P035820 GC19P032328 GC19P035826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD22 Gene:
CD22 (CD22 molecule) is a protein-coding gene. Diseases associated with CD22 include eaf, and lymphosarcoma. An important paralog of this gene is VCAM1.

UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.
Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The
sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon
ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell
antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine
kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains
that block signal transduction through dephosphorylation of signaling molecules

Gene Wiki entry for CD22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD22 gene promoter:
         Sp1   AP-2alpha isoform 3   Egr-1   AP-4   AP-2alpha isoform 2   LCR-F1   AREB6   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD22 promoter sequence
   Search Chromatin IP Primers for CD22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

CD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD22 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035957:  view genomic region     (about GC identifiers)

Start:
35,810,164 bp from pter      End:
35,838,264 bp from pter
Size:
28,101 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD22_HUMAN, P20273 (See protein sequence)
Recommended Name: B-cell receptor CD22 precursor  
Size: 847 amino acids; 95348 Da
Subunit: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter
isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2,
INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1
Sequence caution: Sequence=CAA36988.1; Type=Frameshift; Positions=806;
Secondary accessions: F5GYU4 F5H7U3 O95699 O95701 O95702 O95703 Q01665 Q92872 Q92873 Q9UQA6
Q9UQA7 Q9UQA8 Q9UQA9 Q9UQB0 Q9Y2A6
Alternative splicing: 4 isoforms:  P20273-1   P20273-2   P20273-3   P20273-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CD22: NX_P20273

Explore proteomics data for CD22 at MOPED

Post-translational modifications: 

  • Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively.
    Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R21
  • Phosphorylated on tyrosine residues by LYN (By similarity)1
  • Glycosylation2 at Asn67, Asn101, Asn112, Asn135, Asn164, Asn231, Asn363, Asn445, Asn479, Asn574,
                                 Asn634
  • Modification sites at PhosphoSitePlus

  • See CD22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001172028.1  NP_001172029.1  NP_001172030.1  NP_001265346.1  NP_001762.2  

    ENSEMBL proteins: 
     ENSP00000469980   ENSP00000470681   ENSP00000469503   ENSP00000472664   ENSP00000472762  
     ENSP00000471972   ENSP00000471399   ENSP00000469523   ENSP00000470193   ENSP00000442279  
     ENSP00000085219   ENSP00000441237   ENSP00000403822   ENSP00000469984   ENSP00000470724  
     ENSP00000473221   ENSP00000339349   ENSP00000270311  

    CD22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD22 (Siglec-2/CD22)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD22
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CD22
    OriGene Custom Protein Services for CD22
    GenScript Custom Purified and Recombinant Proteins Services for CD22
    Sino Biological Recombinant Protein for CD22
    Sino Biological Cell Lysate for CD22
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD22 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD22
    R&D Systems Antibodies for CD22 (Siglec-2/CD22)
    OriGene Antibodies for CD22
    OriGene Custom Antibody Services for CD22
    Novus Biologicals CD22 Antibodies
    Abcam antibodies for CD22
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CD22
    LSBio Antibodies in human, mouse, rat for CD22

    CD22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD22
    R&D Systems Proteome Profiler Antibody Arrays for CD22 (Siglec-2/CD22)
    GenScript Custom Assay Services for CD22
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P20273

    ProtoNet protein and cluster: P20273

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
    Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD22_HUMAN, P20273
    Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues.
    Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The
    sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon
    ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell
    antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine
    kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains
    that block signal transduction through dephosphorylation of signaling molecules

         Genatlas biochemistry entry for CD22:
    cell differentiation antigen CD22,glycoprotein,identified by monoclonal antibodies HD39,S-HCL1,TO15,specifically
    expressed in B cells,involved in the regulation of B cell activation sialoadhesin,Ig superfamily,potential
    susceptibility gene for autoimmune diseases

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI8627166
         
    CD22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD22:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cd22):
     cellular  hematopoietic system  immune system  mortality/aging 

    CD22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD22: Cd22tm3Tft Cd22tm1Tft Cd22tm1Lam Cd22tm1Msn Cd22tm1Eac

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD22

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD22:
    hsa-mir-335-5p (MIRT017296)

    Block miRNA regulation of human, mouse, rat CD22 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CD22
    SwitchGear 3'UTR luciferase reporter plasmidCD22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD22
    Predesigned siRNA for gene silencing in human, mouse, rat CD22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD22

    Clone
    Products:
         
    OriGene clones in human, mouse for CD22 (see all 16)
    OriGene ORF clones in mouse, rat for CD22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
    Sino Biological Human cDNA Clone for CD22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD22
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD22_HUMAN, P20273: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    CD22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD22 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    3Hematopoietic cell lineage
    Hematopoietic cell lineage
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    5B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CD22
        Immune response BCR pathway

    2 BioSystems Pathways for CD22
        B Cell Receptor Signaling Pathway
    BCR signaling pathway



    3 Kegg Pathways  (Kegg details for CD22):
        Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage
    B cell receptor signaling pathway


    CD22 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD22: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CD22 (P202731, 2, 3 ENSP000000852194) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 3, ENSP000002440074EBI-78277,EBI-79387 I2D: score=5 STRING: ENSP00000244007
    SYKP434051, 3, ENSP000003648984EBI-78277,EBI-78302 I2D: score=5 STRING: ENSP00000364898
    LYNP079481, 3EBI-78277,EBI-79452 I2D: score=3 
    PTPN6P293501, 3, ENSP000003915924EBI-78277,EBI-78260 I2D: score=5 STRING: ENSP00000391592
    PTPRCP085752, 3, ENSP000003563464MINT-8312050 I2D: score=3 STRING: ENSP00000356346
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    CD22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD22

    5 Novoseek inferred chemical compound relationships for CD22 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epratuzumab 80 3 14503946 (1), 20297867 (1), 11842393 (1)
    sialic acid 63.5 10 7706300 (4), 8702538 (1), 16408005 (1), 11994426 (1) (see all 5)
    tyrosine 35.7 18 10228003 (4), 16782884 (2), 8647200 (2), 8627166 (1) (see all 7)
    polysaccharide 25.6 6 16408005 (4), 12429811 (1)
    oligonucleotide 0 1 12855573 (1)



    CD22 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD22 gene (6 alternative transcripts): 
    NM_024916.1  NM_001185099.1  NM_001185100.1  NM_001185101.1  NM_001278417.1  NM_001771.3  

    Unigene Cluster for CD22:

    CD22 molecule
    Hs.579691  [show with all ESTs]
    Unigene Representative Sequence: NM_001771
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000598537 ENST00000601414 ENST00000595419 ENST00000599717 ENST00000600131
    ENST00000598138 ENST00000599799 ENST00000595780 ENST00000602224 ENST00000597916
    ENST00000596492 ENST00000600905 ENST00000593867 ENST00000601732 ENST00000598028
    ENST00000600424 ENST00000599811 ENST00000598815
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD22 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CD22
    SwitchGear 3'UTR luciferase reporter plasmidCD22 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD22
    Predesigned siRNA for gene silencing in human, mouse, rat CD22
    Clone
    Products:
         
    OriGene clones in human, mouse for CD22 (see all 16)
    OriGene ORF clones in mouse, rat for CD22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD22 (NM_001771)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD22
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD22
      QuantiTect SYBR Green Assays in human, mouse, rat CD22
      QuantiFast Probe-based Assays in human, mouse, rat CD22

    Additional mRNA sequence: 

    AK225625.1 AK225694.1 AK301177.1 BC109306.1 BC109307.1 X52785.1 X59350.1 

    21 DOTS entries:

    DT.452306  DT.121497025  DT.91767061  DT.121497010  DT.100775960  DT.121497018  DT.100775963  DT.121497015 
    DT.95103604  DT.121497029  DT.91767067  DT.95128281  DT.121497027  DT.121497003  DT.121497050  DT.100775956 
    DT.101980011  DT.121497016  DT.95103602  DT.95103603  DT.121497005 

    Selected AceView cDNA sequences (see all 286):

    AI859588 BQ057104 BM478063 BQ055266 BC053347 BM702139 F09020 NM_080600 
    X52785 BQ642447 BQ632310 CR614873 BM475659 BF111811 AW337790 BQ057725 
    BQ890637 BQ059060 AW408631 AW500201 BX350637 F04235 BX280770 BG685870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD22 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
    SP1:                                                                                      -                                                                     
    SP2:                                                                                      -     -     -                                                         
    SP3:                                                                                      -                                               -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 12b · 12c ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:  -     -                                                                                 
    SP4:                                            -                                             
    SP5:  -     -                                   -                                             


    ECgene alternative splicing isoforms for CD22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACCTCCC
    CD22 Expression
    About this image


    CD22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Mature B-Cells Peripheral Blood
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    CD22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.579691

    UniProtKB/Swiss-Prot: CD22_HUMAN, P20273
    Tissue specificity: B-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD22: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD22 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd221 , 5 CD22 antigen1, 5 70.37(n)1
    62.15(a)1
      7 (19.26 cM)5
    124831  NM_001043317.21  NP_001036782.11 
     308654045 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    25(a)
    25(a)
    many → 1
    many → 1
    GL343281.1(335557-362900)
    GL343281.1(315271-325380)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cd221 CD22 molecule 44.59(n)
    30.96(a)
      100135351  XM_002938213.2  XP_002938259.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-27j5.106
    CABZ01058865.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    30(a)
    30(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(57782269-57810365) ENSDARG00000094157
    1(58093921-58105044) ENSDARG00000034098


    ENSEMBL Gene Tree for CD22 (if available)
    TreeFam Gene Tree for CD22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD22 gene
    VCAM12  SIGLEC12  
    3 SIMAP similar genes for CD22 using alignment to 19 protein entries:     CD22_HUMAN (see all proteins):
    PSG11    CEA    FCGR2B

    CD22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD22 (see all 558)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856326241,2
    --35818138(+) TGGGAC/TTTTTT 4 -- us2k10--------
    rs768110961,2
    C,F--35818293(+) AGTCTT/CCTTAT 4 -- us2k11Minor allele frequency- C:0.06EA 120
    rs1396437221,2
    --35818301(+) TATGCG/TTGTCT 4 -- us2k10--------
    rs1499395731,2
    C--35818313(+) GTCACA/GTTCAA 4 -- us2k10--------
    rs770343241,2
    C,F--35818595(+) AGCCCC/TACAGA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs9289371,2
    C,F,A,H--35818609(+) ttgctA/Gtgttg 4 -- us2k127Minor allele frequency- G:0.41NS EA NA WA CSA 2772
    rs9289381,2
    C,F,A,H--35818685(+) caggcG/Ataagt 4 -- us2k1 tfbs325Minor allele frequency- A:0.14NS EA NA WA CSA 2319
    rs1441321361,2
    --35818760(+) CTATGG/TCCAGC 4 -- us2k10--------
    rs177192401,2
    C,F,H--35818831(+) AGGATG/ATGCAT 4 -- us2k18Minor allele frequency- A:0.01NA NS EA 678
    rs1487023231,2
    --35818842(+) GGCTTA/CCAATG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD22 (35810164 - 35838264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2471CNV Loss18451855
    nsv510765CNV Loss20534489
    nsv173CNV Loss15895083
    nsv833810CNV Gain17160897
    dgv1080e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD22
    DNA2.0 Custom Variant and Variant Library Synthesis for CD22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107266    OMIM disorders: --

    Selected diseases for CD22 (see all 28):    
    About MalaCards
    eaf    lymphosarcoma    bullous pemphigoid    precursor b-cell acute lymphoblastic leukemia
    hairy cell leukemia    parathyroid adenoma    acute leukemia    chronic lymphocytic leukemia
    b-cell chronic lymphocytic leukemia    non-hodgkin lymphoma    lymphoblastic leukemia    hodgkin's lymphoma
    t-cell leukemia    systemic lupus erythematosus    b-cell lymphomas    adenoma
    lupus erythematosus    leukemia    tonsillitis    hepatitis b

    3 diseases from the University of Copenhagen DISEASES database for CD22:
    Lymphoma     Leukemia     Systemic lupus erythematosus

    CD22 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for CD22 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 50.5 1 8501986 (1)
    acute leukemia 40.4 1 8501986 (1)
    lymphoma 33.1 4 7706300 (3), 11728231 (1)
    lymphoma b-cell 25.7 1 20122924 (1)
    tumors 3.68 4 7860060 (1), 7706300 (1), 12429643 (1)
    autoimmune diseases 0 1 16782884 (1)
    necrosis 0 2 7706300 (1)
    cancer 0 2 18474217 (1)

    Genetic Association Database (GAD): CD22
    Human Genome Epidemiology (HuGE) Navigator: CD22 (8 documents)

    Export disorders for CD22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD22 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with CD22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. (PubMed id 1691828)1, 2, 3, 9 Stamenkovic I. and Seed B. (Nature 1990)
    2. Identification of the gene variations in human CD22. (PubMed id 10079291)1, 2, 4 Hatta Y....Tokunaga K. (Immunogenetics 1999)
    3. Genomic structure and chromosomal mapping of the human CD22 gene. (PubMed id 8496602)1, 2, 3 Wilson G.L.... Kehrl J.H. (J. Immunol. 1993)
    4. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. (PubMed id 8627166)1, 2, 9 Law C.L.... Clark E.A. (J. Exp. Med. 1996)
    5. Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. (PubMed id 8647200)1, 2, 9 Tuscano J.M.... Kehrl J.H. (Eur. J. Immunol. 1996)
    6. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. (PubMed id 17493148)1, 4 Hitomi Y.... Sato S. (Tissue Antigens 2007)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. (PubMed id 9143697)1, 2 Tedder T.F.... Kehrl J.H. (Annu. Rev. Immunol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 933 HGNC: 1643 AceView: CD22andMAG Ensembl:ENSG00000012124 euGenes: HUgn933
    ECgene: CD22 Kegg: 933 H-InvDB: CD22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD22 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00001
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_269

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD22 gene:
    Search GeneIP for patents involving CD22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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