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CD209 Gene

protein-coding   GIFtS: 62
GCID: GC19M007804

CD209 Molecule

(Previous name: CD209 antigen)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD209 Molecule1 2     C-Type Lectin Domain Family 4 Member L2 3
CD209 Antigen1 2 3     CDSIGN2 5
Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 12 3     C-Type Lectin Domain Family 4, Member L2
CLEC4L2 3     Dendritic Cell-Specific Intracellular Adhesion Molecules (ICAM)-3 Grabbing
Non-Integrin2
DC-SIGN2 3     HIV Gpl20-Binding Protein2
DC-SIGN12 3     

External Ids:    HGNC: 16411   Entrez Gene: 308352   Ensembl: ENSG000000906597   OMIM: 6046725   UniProtKB: Q9NNX63   

Export aliases for CD209 gene to outside databases

Previous GC identifers: GC19M007766 GC19M007909 GC19M007710 GC19M007474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD209 Gene:
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the
surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and
recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on
public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a
tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting
of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion
receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is
important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity.
Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a
significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function
to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their
ligand-binding properties and distribution. Alternative splicing results in multiple variants.(provided by
RefSeq, Feb 2009)

GeneCards Summary for CD209 Gene:
CD209 (CD209 molecule) is a protein-coding gene. Diseases associated with CD209 include dengue disease, and secondary syphilis. GO annotations related to this gene include carbohydrate binding and mannose binding. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6
Function: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in
initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently
degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived
antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen
antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2,
dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella
pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma
mansoni SEA
Function: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May
act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by
binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in
the immunological synapse formed between DC and T-cells

Gene Wiki entry for CD209 (DC-SIGN) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD209 gene promoter:
         Oct-B1   RP58   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   ARP-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD209 promoter sequence
   Search Chromatin IP Primers for CD209

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD209


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

CD209 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD209 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M007804:  view genomic region     (about GC identifiers)

Start:
7,804,879 bp from pter      End:
7,812,464 bp from pter
Size:
7,586 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CD209

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6 (See protein sequence)
Recommended Name: CD209 antigen  
Size: 404 amino acids; 45775 Da
Subunit: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120,
ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E.
Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex
Miscellaneous: In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in
cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious
over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in
non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1
infectious potential during transport by DCs from the periphery to lymphoid organs
Sequence caution: Sequence=AAK91858.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Selected PDB 3D structures from and Proteopedia for CD209 (see all 8):
1K9I (3D)        1SL4 (3D)        1SL5 (3D)        2B6B (3D)        2IT5 (3D)        2IT6 (3D)    
Secondary accessions: A8KAM4 A8MVQ9 G5E9C4 Q2TB19 Q96QP7 Q96QP8 Q96QP9 Q96QQ0 Q96QQ1 Q96QQ2
Q96QQ3 Q96QQ4 Q96QQ5 Q96QQ6 Q96QQ7 Q96QQ8
Alternative splicing: 12 isoforms:  Q9NNX6-1   Q9NNX6-2   Q9NNX6-3   Q9NNX6-4   Q9NNX6-5   Q9NNX6-6   Q9NNX6-7   Q9NNX6-8   
Q9NNX6-9   Q9NNX6-10   Q9NNX6-11   Q9NNX6-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD209: NX_Q9NNX6

Explore proteomics data for CD209 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn80
  • Modification sites at PhosphoSitePlus

  • See CD209 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001138365.1  NP_001138366.1  NP_001138367.1  NP_001138368.1  NP_001138369.1  NP_001138371.1  NP_066978.1  

    ENSEMBL proteins: 
     ENSP00000315477   ENSP00000377728   ENSP00000470530   ENSP00000468827   ENSP00000346373  
     ENSP00000471348   ENSP00000471137   ENSP00000315407   ENSP00000377716   ENSP00000204801  
     ENSP00000470658   ENSP00000301357  

    CD209 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CD209
    OriGene Custom MassSpec
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    Novus Biologicals CD209 Proteins
    Novus Biologicals CD209 Lysates
    Sino Biological Recombinant Protein for CD209
    Sino Biological Cell Lysate for CD209
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD209 Antibody Products:

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    CD209 Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9NNX6

    ProtoNet protein and cluster: Q9NNX6

    1 Blocks protein domain: IPB002353 Type II antifreeze protein signature

    UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6
    Domain: The tandem repeat domain, also called neck domain, mediates oligomerization
    Similarity: Contains 1 C-type lectin domain


    CD209 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD209_HUMAN, Q9NNX6
    Function: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in
    initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently
    degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived
    antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
    Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen
    antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2,
    dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella
    pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma
    mansoni SEA
    Function: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May
    act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by
    binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in
    the immunological synapse formed between DC and T-cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005537mannose binding TAS1518869
    GO:0030246carbohydrate binding NAS11337487
    GO:0042605peptide antigen binding NAS11337487
    GO:0046790virion binding TAS11337487
    GO:0046872metal ion binding IEA--
         
    CD209 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd209a):
     homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 

    CD209 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD209: Cd209atm1.1Cfg Cd209atm1Olne

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD209
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD209

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD209
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD209

    miRNA
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    Block miRNA regulation of human, mouse, rat CD209 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD209:
    hsa-miR-148b* hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidCD209 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD209
    Predesigned siRNA for gene silencing in human, mouse, rat CD209

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 7): CD209 (NM_021155)
    Sino Biological Human cDNA Clone for CD209
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD209


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD209_HUMAN, Q9NNX6: Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 2: Cell membrane; Single-pass type II membrane protein (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 4: Cell membrane; Single-pass type II membrane protein (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 5: Cell membrane; Single-pass type II membrane protein (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 6: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 7: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 8: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 9: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 10: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 11: Secreted (Probable)
    CD209_HUMAN, Q9NNX6: Isoform 12: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    cytosol2
    endosome2
    lysosome2
    nucleus2
    vacuole2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm NAS11337487
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS1518869
    GO:0016021integral component of membrane IEA--

    CD209 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD209 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Measles0.34
    2NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    3Tuberculosis
    Tuberculosis
    4Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CD209
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways




    3 Kegg Pathways  (Kegg details for CD209):
        Phagosome
    Tuberculosis
    Measles


    CD209 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD209: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD209

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CD209 (Q9NNX63 ENSP000003154774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLEC4MQ9H2X33, ENSP000003162284I2D: score=1 STRING: ENSP00000316228
    ICAM3P329423, ENSP000001602624I2D: score=1 STRING: ENSP00000160262
    CEACAM1P136883, ENSP000001615594I2D: score=1 STRING: ENSP00000161559
    ITGAMP112153, ENSP000002874974I2D: score=1 STRING: ENSP00000287497
    ICAM2P135983I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007157heterophilic cell-cell adhesion TAS1518869
    GO:0007159leukocyte cell-cell adhesion NAS11337487
    GO:0009988cell-cell recognition TAS11337487
    GO:0019048modulation by virus of host morphology or physiology TAS11337487

    CD209 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD209

    1 HMDB Compound for CD209    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CD209    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    Selected Novoseek inferred chemical compound relationships for CD209 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 80 60 12695508 (6), 17150970 (3), 11384997 (2), 15385553 (2) (see all 41)
    mannan 68.2 14 17522223 (2), 12438611 (1), 16424204 (1), 18061677 (1) (see all 10)
    polysaccharide 67.1 64 19818504 (5), 18292560 (4), 17055489 (4), 19230080 (2) (see all 31)
    carbohydrates 51.1 6 12797442 (1), 17087964 (1), 12234361 (1), 18310320 (1) (see all 5)
    rantes 40 3 17530998 (2), 16385626 (1)
    galactose 25.2 5 16210905 (1), 20004209 (1), 14990712 (1), 12645947 (1) (see all 5)
    lipid 3.14 3 14709546 (1), 16434485 (1), 19553201 (1)
    allergens 0 4 20080962 (3), 16210905 (1)
    calcium 0 5 15043214 (1), 14970226 (1), 15760448 (1), 16434485 (1)
    tyrosine 0 4 18772280 (2), 16434485 (1)



    CD209 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CD209 gene (7 alternative transcripts): 
    NM_001144893.1  NM_001144894.1  NM_001144895.1  NM_001144896.1  NM_001144897.1  NM_001144899.1  NM_021155.3  

    Unigene Cluster for CD209:

    CD209 molecule
    Hs.278694  [show with all ESTs]
    Unigene Representative Sequence: NR_026692
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315599(uc002mht.2 uc002mhq.2) ENST00000394173(uc010xju.1 uc002mhu.2 uc002mhw.2)
    ENST00000593660 ENST00000601951 ENST00000354397(uc010dvq.2) ENST00000593821
    ENST00000602261 ENST00000315591(uc010dvp.2 uc002mhr.2 uc002mhs.2 uc002mhv.2)
    ENST00000394161(uc010dvr.2) ENST00000204801(uc002mhx.2) ENST00000601256
    ENST00000301357
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 qRT-PCR Assays for microRNAs that regulate CD209:
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    SwitchGear 3'UTR luciferase reporter plasmidCD209 3' UTR sequence
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CD209

    Additional mRNA sequence: 

    AF290886.1 AK057212.1 AK293089.1 AK304190.1 AK308595.1 AK313585.1 AY042221.1 AY042222.1 
    AY042223.1 AY042224.1 AY042225.1 AY042226.1 AY042227.1 AY042228.1 AY042229.1 AY042230.1 
    AY042231.1 AY042232.1 AY042233.1 BC110615.2 M98457.1 NR_026692.1 

    6 DOTS entries:

    DT.75114871  DT.95122402  DT.95302817  DT.95302831  DT.95342360  DT.121473784 

    Selected AceView cDNA sequences (see all 44):

    AY042225 AY042230 AY042226 BX115025 AY042221 AY042224 AY042228 AY042232 
    AA454170 AY042229 AY042233 AY042222 BX481816 M98457 BM685554 BU580036 
    BX472296 AA320008 AI472111 NM_021155 AL705370 AY042227 BX481815 AA453203 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD209    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                -     -     -     -     -                           
    SP2:                                                                                    
    SP3:                    -                                   -     -     -               
    SP4:                                            -                                       


    ECgene alternative splicing isoforms for CD209

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD209 expression in normal human tissues (normalized intensities)      CD209 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCACTACC
    CD209 Expression
    About this image


    CD209 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    CD209 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD209 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278694

    UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6
    Tissue specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental
    macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1
    monocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD209: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Antifungal Response in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD209 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd209a5
    Cd209e1
    CD209a antigen5
    CD209e antigen1
    73.46(n)1
    64.56(a)1
      8 (1.92 cM)5
    1707801  NM_130905.21  NP_570975.11 
     37433955 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-343l4.16
    si:ch73-343l4.56
    (see all 23)
    si:ch73-343l4.5
    (see all 23)
    41(a)
    39(a)
    (see all 23)
    many ↔ many
    many ↔ many
    (see all 23)
    1(56391536-56391818) ENSDARG00000094357
    1(56420677-56430629) ENSDARG00000076778


    ENSEMBL Gene Tree for CD209 (if available)
    TreeFam Gene Tree for CD209 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD209 gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    11 SIMAP similar genes for CD209 using alignment to 3 protein entries:     CD209_HUMAN (see all proteins):
    CLEC4M    CLEC4C    CLEC4E    FCER2    CLEC4D    CLEC6A
    CLEC10A    CLEC2B    REG4    ASGR2    CLEC4G

    CD209 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CD209_HUMAN, Q9NNX6: Genetic variations in CD209 determine Mycobacterium tuberculosis susceptibility [MIM:607948]
    CD209_HUMAN, Q9NNX6: Genetic variations in CD209 may influence susceptibility or resistance to dengue virus infection, as
    well as disease progression and severity [MIM:614371]. A promoter polymorphism in the CD209 gene is associated
    with protection from dengue fever, but not dengue hemorrhagic fever


    Selected SNPs for CD209 (see all 358)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404769401,2
    --7743709(+) GGCAAG/TTGGGT 8 -- ds50010--------
    rs1868672701,2
    --7743732(+) GGAGCC/TTCTGG 8 -- ds50010--------
    rs1456575311,2
    --7743767(+) AGTTCC/GTCTGC 8 -- ds50010--------
    rs750081831,2
    F--7743788(+) TCAACT/ACTTAA 8 -- ds50011Minor allele frequency- A:0.01NA 120
    rs81019491,2
    C,F,A,H--7743831(+) GAAGGC/TGCATC 8 -- ds500114Minor allele frequency- T:0.35NA EU WA CSA EA 470
    rs81125551,2
    C,F,A,H--7743834(+) GGTGCG/ATCTTT 8 -- ds500114Minor allele frequency- A:0.35NA EU WA CSA EA 472
    rs114654281,2
    C,F--7743991(-) CACCTG/TGCATC 8 -- ds50014Minor allele frequency- T:0.07NA EU 214
    rs114654271,2
    C,F,H--7744049(-) ccacaA/Gttttt 8 -- ds500114Minor allele frequency- G:0.43NA EU WA CSA EA 469
    rs1917030081,2
    --7744083(+) TCAGTA/GATTTC 8 -- ds50010--------
    rs112600271,2
    C,F,A,H--7744135(-) ttcggC/Taacaa 8 -- ds500113Minor allele frequency- T:0.43NA EU WA CSA EA 468

    HapMap Linkage Disequilibrium report for CD209 (7804879 - 7812464 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD209:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2751809CNV Gain17911159
    nsv833732CNV Gain17160897

    Human Gene Mutation Database (HGMD): CD209
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD209
    DNA2.0 Custom Variant and Variant Library Synthesis for CD209

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604672   
    OMIM disorders: 614371  609423  607948  
    Selected diseases for CD209 (see all 63):    About MalaCards
    dengue disease    secondary syphilis    dengue fever, protection against    west nile fever
    hiv-1    severe acute respiratory syndrome    syphilis    intrauterine infections
    myxofibrosarcoma    klebsiella    alcoholic hepatitis    tuberculosis
    dengue hemorrhagic fever    lymphadenitis    human immunodeficiency virus infectious disease    tick-borne encephalitis
    aspergillosis    hemorrhagic fever    west nile virus    hepatitis c virus

    3 diseases from the University of Copenhagen DISEASES database for CD209:
    Human immunodeficiency virus infectious disease     Tuberculosis     Dengue disease

    CD209 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CD209 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 69.2 87 11711593 (3), 11226297 (3), 14963164 (3), 11799181 (2) (see all 59)
    renal interstitial fibrosis 53.2 4 19273312 (1), 19273246 (1)
    dengue 52.8 24 12682107 (4), 19941667 (2), 16417930 (2), 19264337 (2) (see all 11)
    tuberculosis 49.6 81 16279841 (5), 16379498 (5), 17224292 (4), 18082570 (4) (see all 31)
    hiv infections 47 22 15905500 (3), 15579280 (2), 12414925 (1), 19879650 (1) (see all 15)
    virus infection 35.9 16 12797442 (2), 15302957 (1), 11581396 (1), 12186897 (1) (see all 13)
    vertical transmission 35.2 5 12653690 (1), 12797442 (1), 11745695 (1), 12562327 (1)
    hepatitis c 25.5 21 18171520 (2), 12634366 (2), 15371595 (2), 15377434 (2) (see all 14)
    immunological diseases 23.4 2 11799126 (1), 12797442 (1)
    chronic periodontitis 23.1 2 15111627 (1), 18771763 (1)

    Genetic Association Database (GAD): CD209
    Human Genome Epidemiology (HuGE) Navigator: CD209 (45 documents)

    Export disorders for CD209 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CD209 gene, integrated from 10 sources (see all 535):
    (articles sorted by number of sources associating them with CD209)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A variant in the CD209 promoter is associated with severity of dengue disease. (PubMed id 15838506)1, 2, 4 Sakuntabhai A.... Julier C. (Nat. Genet. 2005)
    2. Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp 120. (PubMed id 1518869)1, 2, 3 Curtis B.M.... Watson A.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. Extensive repertoire of membrane-bound and soluble dendritic cell- specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. (PubMed id 11337487)1, 2, 9 Mummidi S.... Ahuja S.K. (J. Biol. Chem. 2001)
    4. DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility. (PubMed id 17509452)1, 4, 9 Boily-Larouche G....Roger M. (Hum. Immunol. 2007)
    5. Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN. (PubMed id 12692233)1, 2, 9 Nobile C.... Schwartz O. (J. Virol. 2003)
    6. Identification of different binding sites in the dendritic cell- specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. (PubMed id 11799126)1, 2, 9 Geijtenbeek T.B.H.... van Kooyk Y. (J. Biol. Chem. 2002)
    7. Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. (PubMed id 18082570)1, 4, 9 Ben-Ali M....Barbouche M.R. (Hum. Immunol. 2007)
    8. CD209 genetic polymorphism and tuberculosis disease. (PubMed id 18167547)1, 4, 9 Vannberg F.O....Hill A.V. (PLoS ONE 2008)
    9. Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals. (PubMed id 17876530)1, 4, 9 Rathore A....Dhole T.N. (J. Clin. Immunol. 2008)
    10. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. (PubMed id 17611589)1, 4, 9 Olesen R....Sirugo G. (Genes Immun. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 30835 HGNC: 1641 AceView: CD209 Ensembl:ENSG00000090659 euGenes: HUgn30835
    ECgene: CD209 Kegg: 30835 H-InvDB: CD209

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD209 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/DC-SIGN
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00121

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD209 gene:
    Search GeneIP for patents involving CD209

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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