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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD209 Gene

protein-coding GIFtS: 64
GCID: GC19M007804

CD209 molecule

(Previous name: CD209 antigen )

Explore 52 diseases affiliated with
CD209 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD209 Molecule¹ ²		Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 1² ³
CLEC4L¹ ² ³		C-Type Lectin Domain Family 4 Member L² ³
DC-SIGN¹ ² ³		C-Type Lectin Domain Family 4, Member L²
DC-SIGN1¹ ² ³		Dendritic Cell-Specific Intracellular Adhesion Molecules (ICAM)-3 Grabbing Non-Integrin²
CD209 Antigen¹ ² ³		HIV Gpl20-Binding Protein²
CDSIGN¹ ² ⁵

External Ids:	HGNC: 1641¹	Entrez Gene: 30835²	Ensembl: ENSG00000090659⁷	OMIM: 604672⁵	UniProtKB: Q9NNX6³

ORGUL members:
	NONCODE:n407224

Export aliases for CD209 gene to outside databases

Previous GC identifers: GC19M007766 GC19M007909 GC19M007710 GC19M007474

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD209:

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface

of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes

numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health.

The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain

and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck

domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate

ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which

allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats

in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is

closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as

L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results

in multiple variants.(provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6

Function: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in

initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded

in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are

presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes

in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including

HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania

pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and

tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA

Function: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act

as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding

endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the

immunological synapse formed between DC and T-cells

Gene Wiki entry for CD209 (DC-SIGN)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD209 gene promoter:
Oct-B1 RP58 oct-B3 oct-B2 POU2F2 POU2F1 POU2F1a ARP-1 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD209 promoter sequence

Search SABiosciences Chromatin IP Primers for CD209

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD209

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13

CD209 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD209 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M007804: view genomic region (about GC identifiers)

Start:	7,804,879 bp from pter	End:	7,812,464 bp from pter
Size:	7,586 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6 (See protein sequence)

Recommended Name: CD209 antigen

Size: 404 amino acids; 45775 Da

Subunit: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120,

ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Interacts

with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex

Subcellular location: Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable)

Subcellular location: Isoform 2: Cell membrane; Single-pass type II membrane protein (Probable)

Subcellular location: Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable)

Subcellular location: Isoform 4: Cell membrane; Single-pass type II membrane protein (Probable)

Subcellular location: Isoform 5: Cell membrane; Single-pass type II membrane protein (Probable)

Subcellular location: Isoform 6: Secreted (Probable)

Subcellular location: Isoform 7: Secreted (Probable)

Subcellular location: Isoform 8: Secreted (Probable)

Subcellular location: Isoform 9: Secreted (Probable)

Subcellular location: Isoform 10: Secreted (Probable)

Subcellular location: Isoform 11: Secreted (Probable)

Subcellular location: Isoform 12: Secreted (Probable)

Miscellaneous: In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis

following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a

prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic

organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during

transport by DCs from the periphery to lymphoid organs

Sequence caution: Sequence=AAK91858.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

6/8 PDB 3D structures from and Proteopedia for CD209 (see all 8):

1K9I (3D)

1SL4 (3D)

1SL5 (3D)

2B6B (3D)

2IT5 (3D)

2IT6 (3D)

Secondary accessions: A8KAM4 A8MVQ9 Q2TB19 Q96QP7 Q96QP8 Q96QP9 Q96QQ0 Q96QQ1 Q96QQ2 Q96QQ3 Q96QQ4

Q96QQ5 Q96QQ6 Q96QQ7 Q96QQ8

Alternative splicing: 12 isoforms: Q9NNX6-1 Q9NNX6-2 Q9NNX6-3 Q9NNX6-4 Q9NNX6-5 Q9NNX6-6 Q9NNX6-7 Q9NNX6-8

Q9NNX6-9 Q9NNX6-10 Q9NNX6-11 Q9NNX6-12 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD209: NX_Q9NNX6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NNX6

CD209 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001138365.1 NP_001138366.1 NP_001138367.1 NP_001138368.1 NP_001138369.1 NP_001138371.1 NP_066978.1

ENSEMBL proteins:

ENSP00000315477 ENSP00000346373 ENSP00000315407 ENSP00000204801 ENSP00000377728

ENSP00000301357 ENSP00000377716

Human Recombinant Protein Products for CD209:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD209 (DC-SIGN/CD209)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CD209 OriGene Custom Protein Services for CD209
	GenScript Custom Purified and Recombinant Proteins Services for CD209
	Novus Biologicals CD209 Proteins Novus Biologicals CD209 Lysates
	Sino Biological Recombinant Protein for CD209
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD209

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	NAS	11337487
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	TAS	1518869

CD209 for ontologies About GeneDecksing

CD209 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD209 (DC-SIGN/CD209, DC-SIGN+DC-SIGNR)
	Cell Signaling Technology (CST) Antibodies for CD209
	OriGene Antibodies (see all 3): CD209 OriGene Custom Antibody Services for CD209
	GenScript Custom Superior Antibodies Services for CD209
	Novus Biologicals CD209 Antibodies
	Abcam antibodies for CD209
	Uscn Antibodies for CD209
	ThermoFisher Antibody for CD209

Assay Products for CD209:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD209
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD209

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD209 for domains About GeneDecksing

4 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q9NNX6

ProtoNet protein and cluster: Q9NNX6

1 Blocks protein family: IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: CD209_HUMAN, Q9NNX6

Domain: The tandem repeat domain, also called neck domain, mediates oligomerization

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD209_HUMAN, Q9NNX6