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Aliases for CD209 Gene

Aliases for CD209 Gene

  • CD209 Molecule 2 3 5
  • CD209 Antigen 2 3 4
  • Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 1 3 4
  • C-Type Lectin Domain Family 4 Member L 3 4
  • DC-SIGN1 3 4
  • DC-SIGN 3 4
  • CLEC4L 3 4
  • Dendritic Cell-Specific Intracellular Adhesion Molecules (ICAM)-3 Grabbing Non-Integrin 3
  • Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin 3
  • HIV Gpl20-Binding Protein 3
  • CDSIGN 3

External Ids for CD209 Gene

Previous GeneCards Identifiers for CD209 Gene

  • GC19M007766
  • GC19M007909
  • GC19M007710
  • GC19M007474

Summaries for CD209 Gene

Entrez Gene Summary for CD209 Gene

  • This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for CD209 Gene

CD209 (CD209 Molecule) is a Protein Coding gene. Diseases associated with CD209 include Hiv-1 and Dengue Fever, Protection Against. Among its related pathways are Toll-Like receptor Signaling Pathways and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include carbohydrate binding and mannose binding. An important paralog of this gene is CLEC4M.

UniProtKB/Swiss-Prot for CD209 Gene

  • Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.

  • On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

  • (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2 (PubMed:11799126, PubMed:12502850, PubMed:1518869). Acts as an attachment receptor for ebolavirus (PubMed:12502850, PubMed:12504546). Acts as an attachment receptor for cytomegalovirus (PubMed:12433371, PubMed:22496863). Acts as an attachment receptor for HCV (PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for dengue virus (PubMed:12682107). Acts as an attachment receptor for measles virus (PubMed:16537615). Acts as an attachment receptor for herpes simplex virus 1 (PubMed:18796707). Acts as an attachment receptor for Influenzavirus A (PubMed:21191006). Acts as an attachment receptor for SARS coronavirus (PubMed:15140961). Acts as an attachment receptor for Japanese encephalitis virus (PubMed:24623090). Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for marburg virusn (PubMed:15479853). Acts as an attachment receptor for Respiratory syncytial virus (PubMed:22090124). Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus (PubMed:21767814). Acts as an attachment receptor for west-nile virus (PubMed:16415006). Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).

Gene Wiki entry for CD209 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD209 Gene

Genomics for CD209 Gene

Regulatory Elements for CD209 Gene

Enhancers for CD209 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G007700 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +43.1 43118 7.0 HDGF PKNOX1 YBX1 ELK1 ZNF143 ZNF207 JUNB TBX21 ZNF610 NBN STXBP2 FCER2 PEX11G CD209 CLEC4G RPL21P129 MCEMP1 MCOLN1 PNPLA6 RAB11B-AS1
GH19G007714 1.1 Ensembl ENCODE dbSUPER 17 +32.8 32799 1.3 PKNOX1 DPF2 MNT MBD2 CTBP1 GATA3 ZNF544 CREB1 CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 ZNF414 CLEC4G FCER2 XAB2 LOC105372262
GH19G007772 1.1 Ensembl ENCODE 13.3 -25.4 -25396 0.8 PKNOX1 BMI1 ZSCAN5C RELB IKZF2 CREM CBFB JUNB GATAD2B ELF1 RPL21P129 CD209 FCER2 CLEC4G CLEC4GP1 LOC105372263 GC19P007785
GH19G007799 1.1 Ensembl ENCODE 11.8 -52.3 -52296 1.4 PTBP1 FOXA2 KLF17 NFXL1 RAD21 RFX5 RELB MIXL1 SMARCA5 ZNF654 TRAPPC5 MCEMP1 CLEC4G RPL21P129 CD209 PET100 XAB2 LRRC8E PRR36 CLEC4GP1
GH19G007807 1 ENCODE 11.6 -60.2 -60238 0.9 PKNOX1 AGO1 ARID4B ZNF48 GLIS2 CBX5 FOS KLF7 SP3 JUNB TRAPPC5 MCEMP1 RPL21P129 CD209 CLEC4G PEX11G TEX45 EXOSC3P2 CLEC4GP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD209 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD209 Gene

Chromosome:
19
Start:
7,739,988 bp from pter
End:
7,747,605 bp from pter
Size:
7,618 bases
Orientation:
Minus strand

Genomic View for CD209 Gene

Genes around CD209 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD209 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD209 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD209 Gene

Proteins for CD209 Gene

  • Protein details for CD209 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNX6-CD209_HUMAN
    Recommended name:
    CD209 antigen
    Protein Accession:
    Q9NNX6
    Secondary Accessions:
    • A8KAM4
    • A8MVQ9
    • G5E9C4
    • Q2TB19
    • Q96QP7
    • Q96QP8
    • Q96QP9
    • Q96QQ0
    • Q96QQ1
    • Q96QQ2
    • Q96QQ3
    • Q96QQ4
    • Q96QQ5
    • Q96QQ6
    • Q96QQ7
    • Q96QQ8

    Protein attributes for CD209 Gene

    Size:
    404 amino acids
    Molecular mass:
    45775 Da
    Quaternary structure:
    • Homotetramer. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates. Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332).
    • (Microbial infection) Interacts with HIV-1 and HIV-2 gp120 (PubMed:11799126, PubMed:12502850, PubMed:1518869).
    • (Microbial infection) Interacts with ebolavirus envelope glycoproteins (PubMed:12502850, PubMed:12504546).
    • (Microbial infection) Interacts with cytomegalovirus gB protein (PubMed:12433371, PubMed:22496863).
    • (Microbial infection) Interacts with HCV E2 protein (PubMed:15371595, PubMed:16816373).
    • (Microbial infection) Interacts with dengue virus major envelope protein E.
    • (Microbial infection) Interacts with measles hemagglutinin.
    • (Microbial infection) Interacts with herpes simplex virus 1 surface proteins.
    • (Microbial infection) Interacts with Influenzavirus A hemagglutinin.
    • (Microbial infection) Interacts with SARS coronavirus glycoprotein.
    • (Microbial infection) Interacts with Japanese encephalitis virus E protein.
    • (Microbial infection) Interacts with Lassa virus Glycoprotein.
    • (Microbial infection) Interacts with marburg virus glycoprotein.
    • (Microbial infection) Interacts with Respiratory syncytial virus glycoprotein G.
    • (Microbial infection) Interacts with Rift valley fever virus and uukuniemi virus envelope glycoprotein.
    • (Microbial infection) Interacts with west-nile virus envelope glycoprotein.
    • (Microbial infection) Interacts with whole M.bovis cells in a Ca(2+)-dependent and independent manner; in vitro experiments suggest it interacts with CH60.1 (groL1), DnaK, GADPH (gap) and LrpG (PubMed:21203928).
    Miscellaneous:
    • In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during transport by DCs from the periphery to lymphoid organs.
    SequenceCaution:
    • Sequence=AAK91858.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD209 Gene

    Alternative splice isoforms for CD209 Gene

neXtProt entry for CD209 Gene

Post-translational modifications for CD209 Gene

  • Glycosylation at posLast=8080
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CD209 (DC-SIGN/CD209)
  • R&D Systems Antibodies for CD209 (DC-SIGN+DC-SIGNR)
  • Cell Signaling Technology (CST) Antibodies for CD209 (CD209)
  • Abcam antibodies for CD209

Protein Products

No data available for DME Specific Peptides for CD209 Gene

Domains & Families for CD209 Gene

Suggested Antigen Peptide Sequences for CD209 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NNX6

UniProtKB/Swiss-Prot:

CD209_HUMAN :
  • The tandem repeat domain, also called neck domain, mediates oligomerization.
Domain:
  • The tandem repeat domain, also called neck domain, mediates oligomerization.
genes like me logo Genes that share domains with CD209: view

Function for CD209 Gene

Molecular function for CD209 Gene

UniProtKB/Swiss-Prot Function:
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
UniProtKB/Swiss-Prot Function:
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2 (PubMed:11799126, PubMed:12502850, PubMed:1518869). Acts as an attachment receptor for ebolavirus (PubMed:12502850, PubMed:12504546). Acts as an attachment receptor for cytomegalovirus (PubMed:12433371, PubMed:22496863). Acts as an attachment receptor for HCV (PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for dengue virus (PubMed:12682107). Acts as an attachment receptor for measles virus (PubMed:16537615). Acts as an attachment receptor for herpes simplex virus 1 (PubMed:18796707). Acts as an attachment receptor for Influenzavirus A (PubMed:21191006). Acts as an attachment receptor for SARS coronavirus (PubMed:15140961). Acts as an attachment receptor for Japanese encephalitis virus (PubMed:24623090). Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for marburg virusn (PubMed:15479853). Acts as an attachment receptor for Respiratory syncytial virus (PubMed:22090124). Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus (PubMed:21767814). Acts as an attachment receptor for west-nile virus (PubMed:16415006). Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).

Gene Ontology (GO) - Molecular Function for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 12609975
GO:0005537 mannose binding TAS 1518869
GO:0030246 carbohydrate binding NAS 11337487
GO:0042605 peptide antigen binding NAS 11337487
genes like me logo Genes that share ontologies with CD209: view
genes like me logo Genes that share phenotypes with CD209: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD209 Gene

Localization for CD209 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD209 Gene

Isoform 1: Cell membrane; Single-pass type II membrane protein.
Isoform 2: Cell membrane; Single-pass type II membrane protein.
Isoform 3: Cell membrane; Single-pass type II membrane protein.
Isoform 4: Cell membrane; Single-pass type II membrane protein.
Isoform 5: Cell membrane; Single-pass type II membrane protein.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.
Isoform 9: Secreted.
Isoform 10: Secreted.
Isoform 11: Secreted.
Isoform 12: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD209 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytosol 2
lysosome 2
endosome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm NAS 11337487
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 24942581
GO:0009986 cell surface IDA 23981064
genes like me logo Genes that share ontologies with CD209: view

Pathways & Interactions for CD209 Gene

genes like me logo Genes that share pathways with CD209: view

Gene Ontology (GO) - Biological Process for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD209: view

No data available for SIGNOR curated interactions for CD209 Gene

Drugs & Compounds for CD209 Gene

(4) Drugs for CD209 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(9) Additional Compounds for CD209 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with CD209: view

Transcripts for CD209 Gene

Unigene Clusters for CD209 Gene

CD209 molecule:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD209 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -

Relevant External Links for CD209 Gene

GeneLoc Exon Structure for
CD209
ECgene alternative splicing isoforms for
CD209

Expression for CD209 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD209 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD209 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x7.6) and Adipose - Subcutaneous (x4.6).

Protein differential expression in normal tissues from HIPED for CD209 Gene

This gene is overexpressed in Liver, secretome (24.6), Skin (13.9), and Placenta (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD209 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD209 Gene:

CD209

SOURCE GeneReport for Unigene cluster for CD209 Gene:

Hs.278694

mRNA Expression by UniProt/SwissProt for CD209 Gene:

Q9NNX6-CD209_HUMAN
Tissue specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

Evidence on tissue expression from TISSUES for CD209 Gene

  • Lymph node(3.6)
  • Spleen(3.5)
  • Blood(2.7)
  • Liver(2.7)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with CD209: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD209 Gene

Orthologs for CD209 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD209 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD209 34 35
  • 97.54 (n)
rat
(Rattus norvegicus)
Mammalia Cd209e 34
  • 73.86 (n)
mouse
(Mus musculus)
Mammalia Cd209e 34 16 35
  • 73.46 (n)
Cd209d 35
  • 57 (a)
ManyToMany
Cd209b 35
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-343l4.1 35
  • 41 (a)
ManyToMany
si:ch73-343l4.4 35
  • 39 (a)
ManyToMany
si:ch73-343l4.5 35
  • 39 (a)
ManyToMany
CABZ01029886.1 35
  • 36 (a)
ManyToMany
si:ch73-343l4.3 35
  • 36 (a)
ManyToMany
si:dkey-12f6.5 35
  • 34 (a)
ManyToMany
CU695221.2 35
  • 27 (a)
ManyToMany
CR847844.3 35
  • 26 (a)
ManyToMany
si:dkey-181c13.1 35
  • 26 (a)
ManyToMany
si:ch73-343l4.8 35
  • 25 (a)
ManyToMany
zgc:174904 35
  • 24 (a)
ManyToMany
CR847844.1 35
  • 23 (a)
ManyToMany
CR847844.2 35
  • 23 (a)
ManyToMany
CR847844.4 35
  • 23 (a)
ManyToMany
si:ch211-214k5.3 35
  • 21 (a)
ManyToMany
si:ch73-111e15.1 35
  • 20 (a)
ManyToMany
si:ch73-122g19.1 35
  • 20 (a)
ManyToMany
si:ch73-343l4.2 35
  • 19 (a)
ManyToMany
CR847844.6 35
  • 17 (a)
ManyToMany
cd209 35
  • 15 (a)
ManyToMany
CABZ01036814.1 35
  • 13 (a)
ManyToMany
si:ch73-343l4.6 35
  • 13 (a)
ManyToMany
si:dkey-187i8.2 35
  • 11 (a)
ManyToMany
Species where no ortholog for CD209 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD209 Gene

ENSEMBL:
Gene Tree for CD209 (if available)
TreeFam:
Gene Tree for CD209 (if available)

Paralogs for CD209 Gene

(11) SIMAP similar genes for CD209 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD209: view

Variants for CD209 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD209 Gene

CD209_HUMAN-Q9NNX6
Genetic variations in CD209 may influence susceptibility or resistance to dengue virus infection, as well as disease progression and severity [MIM:614371]. A promoter polymorphism in the CD209 gene is associated with protection from dengue fever, but not dengue hemorrhagic fever.
CD209_HUMAN-Q9NNX6
Genetic variations in the CD209 promoter determine M.tuberculosis susceptibility [MIM:607948] (PubMed:16379498).

Sequence variations from dbSNP and Humsavar for CD209 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000176268 -- 7,746,584(+) TGGCC(C/T)AGGGA intron-variant
rs1000615810 -- 7,742,705(+) AACAG(A/G)TGGTA nc-transcript-variant, utr-variant-3-prime
rs1000683602 -- 7,745,077(+) GACAG(A/G)GGTGG nc-transcript-variant, reference, missense
rs1001617290 -- 7,743,868(+) TAATA(C/T)ATTAT intron-variant
rs1001680981 -- 7,743,361(+) AATCC(C/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD209 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833732 CNV gain 17160897

Variation tolerance for CD209 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD209 Gene

Human Gene Mutation Database (HGMD)
CD209
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD209

Disorders for CD209 Gene

MalaCards: The human disease database

(30) MalaCards diseases for CD209 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
dengue fever, protection against
  • dengue virus, susceptibility to dengue fever, susceptibility to, included
mycobacterium tuberculosis, susceptibility to mycobacterium tuberculosis, protection against, included
  • tuberculosis
encephalitis
tuberculosis
  • kochs disease
- elite association - COSMIC cancer census association via MalaCards
Search CD209 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD209

Genetic Association Database (GAD)
CD209
Human Genome Epidemiology (HuGE) Navigator
CD209
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD209
genes like me logo Genes that share disorders with CD209: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD209 Gene

Publications for CD209 Gene

  1. CD209 genetic polymorphism and tuberculosis disease. (PMID: 18167547) Vannberg F.O. … Hill A.V. (PLoS ONE 2008) 3 22 46 64
  2. RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs. (PMID: 17530998) Koizumi Y. … Ichimura H. (AIDS Res. Hum. Retroviruses 2007) 3 22 46 64
  3. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. (PMID: 17611589) Olesen R. … Sirugo G. (Genes Immun. 2007) 3 22 46 64
  4. Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. (PMID: 18082570) Ben-Ali M. … Barbouche M.R. (Hum. Immunol. 2007) 3 22 46 64
  5. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. (PMID: 16379498) Barreiro L.B. … Quintana-Murci L. (PLoS Med. 2006) 3 4 22 64

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