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Aliases for CD209 Gene

Aliases for CD209 Gene

  • CD209 Molecule 2 3
  • CD209 Antigen 2 3 4
  • Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 1 3 4
  • C-Type Lectin Domain Family 4 Member L 3 4
  • DC-SIGN1 3 4
  • DC-SIGN 3 4
  • CDSIGN 3 6
  • CLEC4L 3 4
  • Dendritic Cell-Specific Intracellular Adhesion Molecules (ICAM)-3 Grabbing Non-Integrin 3
  • C-Type Lectin Domain Family 4, Member L 3
  • HIV Gpl20-Binding Protein 3

External Ids for CD209 Gene

Summaries for CD209 Gene

Entrez Gene Summary for CD209 Gene

  • This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for CD209 Gene

CD209 (CD209 Molecule) is a Protein Coding gene. Diseases associated with CD209 include secondary syphilis and dengue disease. Among its related pathways are NOD-like Receptor Signaling Pathways and Tuberculosis. GO annotations related to this gene include carbohydrate binding and mannose binding. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for CD209 Gene

  • Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA

  • On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells

Gene Wiki entry for CD209 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD209 Gene

Genomics for CD209 Gene

Genomic Location for CD209 Gene

Start:
7,739,993 bp from pter
End:
7,747,611 bp from pter
Size:
7,619 bases
Orientation:
Minus strand

Genomic View for CD209 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD209 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD209 Gene

Regulatory Elements for CD209 Gene

Proteins for CD209 Gene

  • Protein details for CD209 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNX6-CD209_HUMAN
    Recommended name:
    CD209 antigen
    Protein Accession:
    Q9NNX6
    Secondary Accessions:
    • A8KAM4
    • A8MVQ9
    • G5E9C4
    • Q2TB19
    • Q96QP7
    • Q96QP8
    • Q96QP9
    • Q96QQ0
    • Q96QQ1
    • Q96QQ2
    • Q96QQ3
    • Q96QQ4
    • Q96QQ5
    • Q96QQ6
    • Q96QQ7
    • Q96QQ8

    Protein attributes for CD209 Gene

    Size:
    404 amino acids
    Molecular mass:
    45775 Da
    Quaternary structure:
    • Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex.
    Miscellaneous:
    • In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during transport by DCs from the periphery to lymphoid organs
    SequenceCaution:
    • Sequence=AAK91858.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD209 Gene

    Alternative splice isoforms for CD209 Gene

neXtProt entry for CD209 Gene

Proteomics data for CD209 Gene at MOPED

Post-translational modifications for CD209 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn80

No data available for DME Specific Peptides for CD209 Gene

Domains for CD209 Gene

Gene Families for CD209 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

UniProtKB/Swiss-Prot:

CD209_HUMAN
Domain:
  • The tandem repeat domain, also called neck domain, mediates oligomerization:
    • Q9NNX6
  • Contains 1 C-type lectin domain.:
    • Q9NNX6
genes like me logo Genes that share domains with CD209: view

Function for CD209 Gene

Molecular function for CD209 Gene

UniProtKB/Swiss-Prot Function: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA
UniProtKB/Swiss-Prot Function: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells

Gene Ontology (GO) - Molecular Function for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12609975
GO:0005537 mannose binding TAS 1518869
GO:0030246 carbohydrate binding NAS 11337487
GO:0042605 peptide antigen binding NAS 11337487
GO:0046790 virion binding TAS 11337487
genes like me logo Genes that share ontologies with CD209: view
genes like me logo Genes that share phenotypes with CD209: view

Animal Models for CD209 Gene

MGI Knock Outs for CD209:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD209 Gene

Localization for CD209 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD209 Gene

Isoform 1: Cell membrane; Single-pass type II membrane protein.
Isoform 2: Cell membrane; Single-pass type II membrane protein.
Isoform 3: Cell membrane; Single-pass type II membrane protein.
Isoform 4: Cell membrane; Single-pass type II membrane protein.
Isoform 5: Cell membrane; Single-pass type II membrane protein.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 8: Secreted.
Isoform 9: Secreted.
Isoform 10: Secreted.
Isoform 11: Secreted.
Isoform 12: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD209 Gene COMPARTMENTS Subcellular localization image for CD209 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
endosome 2
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11337487
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 23981064
GO:0016020 membrane TAS 1518869
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD209: view

Pathways for CD209 Gene

genes like me logo Genes that share pathways with CD209: view

Pathways by source for CD209 Gene

3 KEGG pathways for CD209 Gene

Gene Ontology (GO) - Biological Process for CD209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006897 endocytosis IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS 1518869
GO:0007159 leukocyte cell-cell adhesion NAS 11337487
GO:0009988 cell-cell recognition TAS 11337487
genes like me logo Genes that share ontologies with CD209: view

Compounds for CD209 Gene

(1) HMDB Compounds for CD209 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CD209 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(12) Novoseek inferred chemical compound relationships for CD209 Gene

Compound -log(P) Hits PubMed IDs
mannose 80 51
mannan 68.2 11
polysaccharide 67.1 44
carbohydrates 51.1 5
rantes 40 3
genes like me logo Genes that share compounds with CD209: view

Transcripts for CD209 Gene

Unigene Clusters for CD209 Gene

CD209 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD209 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -

Relevant External Links for CD209 Gene

GeneLoc Exon Structure for
CD209
ECgene alternative splicing isoforms for
CD209

Expression for CD209 Gene

mRNA expression in normal human tissues for CD209 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD209 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (7.6) and Adipose - Subcutaneous (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD209 Gene

SOURCE GeneReport for Unigene cluster for CD209 Gene Hs.278694

mRNA Expression by UniProt/SwissProt for CD209 Gene

Q9NNX6-CD209_HUMAN
Tissue specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
genes like me logo Genes that share expressions with CD209: view

Orthologs for CD209 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD209 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD209 36
  • 97.54 (n)
  • 95.93 (a)
CD209 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd209a 16
Cd209b 37
  • 42 (a)
ManyToMany
Cd209d 37
  • 57 (a)
ManyToMany
Cd209e 36
  • 73.46 (n)
  • 64.56 (a)
Cd209e 37
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cd209e 36
  • 73.86 (n)
  • 62.25 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01029886.1 37
  • 36 (a)
ManyToMany
CABZ01036814.1 37
  • 13 (a)
ManyToMany
cd209 37
  • 15 (a)
ManyToMany
CR847844.1 37
  • 23 (a)
ManyToMany
CR847844.2 37
  • 23 (a)
ManyToMany
CR847844.3 37
  • 26 (a)
ManyToMany
CR847844.4 37
  • 23 (a)
ManyToMany
CR847844.6 37
  • 17 (a)
ManyToMany
CU695221.2 37
  • 27 (a)
ManyToMany
si:ch211-214k5.3 37
  • 21 (a)
ManyToMany
si:ch73-111e15.1 37
  • 20 (a)
ManyToMany
si:ch73-122g19.1 37
  • 20 (a)
ManyToMany
si:ch73-343l4.1 37
  • 41 (a)
ManyToMany
si:ch73-343l4.2 37
  • 19 (a)
ManyToMany
si:ch73-343l4.3 37
  • 36 (a)
ManyToMany
si:ch73-343l4.4 37
  • 39 (a)
ManyToMany
si:ch73-343l4.5 37
  • 39 (a)
ManyToMany
si:ch73-343l4.6 37
  • 13 (a)
ManyToMany
si:ch73-343l4.8 37
  • 25 (a)
ManyToMany
si:dkey-12f6.5 37
  • 34 (a)
ManyToMany
si:dkey-181c13.1 37
  • 26 (a)
ManyToMany
si:dkey-187i8.2 37
  • 11 (a)
ManyToMany
zgc:174904 37
  • 24 (a)
ManyToMany
Species with no ortholog for CD209:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD209 Gene

ENSEMBL:
Gene Tree for CD209 (if available)
TreeFam:
Gene Tree for CD209 (if available)

Paralogs for CD209 Gene

Selected SIMAP similar genes for CD209 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD209: view

Variants for CD209 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD209 Gene

Q9NNX6-CD209_HUMAN
Genetic variations in CD209 determine Mycobacterium tuberculosis susceptibility [MIM:607948]

Sequence variations from dbSNP and Humsavar for CD209 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs735239 -- 7,748,382(+) ataac(A/G)tagat upstream-variant-2KB
rs735240 -- 7,748,450(+) atttt(A/G)tgtga upstream-variant-2KB
rs1544766 -- 7,741,837(+) AGAGG(A/G)TGGGC utr-variant-3-prime, nc-transcript-variant
rs1544767 -- 7,741,982(+) TCACC(A/T)AGCAG utr-variant-3-prime, nc-transcript-variant
rs2287886 -- 7,747,650(+) AAAAG(A/G)CTAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD209 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv833732 CNV Gain 17160897

Relevant External Links for CD209 Gene

HapMap Linkage Disequilibrium report
CD209
Human Gene Mutation Database (HGMD)
CD209

Disorders for CD209 Gene

(3) OMIM Diseases for CD209 Gene (604672)

(3) University of Copenhagen DISEASES for CD209 Gene

(25) Novoseek inferred disease relationships for CD209 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 69.2 74
renal interstitial fibrosis 53.2 2
dengue 52.8 17
tuberculosis 49.6 63
hiv infections 47 18

Relevant External Links for CD209

Genetic Association Database (GAD)
CD209
Human Genome Epidemiology (HuGE) Navigator
CD209
genes like me logo Genes that share disorders with CD209: view

No data available for UniProtKB/Swiss-Prot for CD209 Gene

Publications for CD209 Gene

  1. Extensive repertoire of membrane-bound and soluble dendritic cell- specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. (PMID: 11337487) Mummidi S. … Ahuja S.K. (J. Biol. Chem. 2001) 3 4 23
  2. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. (PMID: 11384997) Mitchell D.A. … Drickamer K. (J. Biol. Chem. 2001) 3 4 23
  3. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. (PMID: 11257134) Bashirova A.A. … Carrington M. (J. Exp. Med. 2001) 3 4 23
  4. Structural basis for selective recognition of oligosaccharides by DC- SIGN and DC-SIGNR. (PMID: 11739956) Feinberg H. … Weis W.I. (Science 2001) 3 4 23
  5. Identification of different binding sites in the dendritic cell- specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. (PMID: 11799126) Geijtenbeek T.B.H. … van Kooyk Y. (J. Biol. Chem. 2002) 3 4 23

Products for CD209 Gene

Sources for CD209 Gene

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