Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CD207 Gene

protein-coding   GIFtS: 53
GCID: GC02M071057

CD207 Molecule, Langerin

(Previous names: CD207 antigen, langerin)
  See CD207-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CD207 Molecule, Langerin1 2     Langerhans Cell Specific C-Type Lectin2
CLEC4K2 3 5     Langerin3
CD207 Antigen, Langerin1 2     CD207 Antigen3
C-Type Lectin Domain Family 4 Member K2     LANGERIN5
C-Type Lectin Domain Family 4, Member K2     

External Ids:    HGNC: 179351   Entrez Gene: 504892   Ensembl: ENSG000001160317   OMIM: 6048625   UniProtKB: Q9UJ713   

Export aliases for CD207 gene to outside databases

Previous GC identifers: GC02M071015 GC02M071031 GC02M070969 GC02M070793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CD207 Gene:
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the
epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans
cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding
specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen
into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene
result in Birbeck granules deficiency or loss of sugar binding activity. (provided by RefSeq, Aug 2010)

GeneCards Summary for CD207 Gene:
CD207 (CD207 molecule, langerin) is a protein-coding gene. Diseases associated with CD207 include allergic conjunctivitis, and malignant ependymoma. GO annotations related to this gene include carbohydrate binding and mannose binding. An important paralog of this gene is CLEC17A.

UniProtKB/Swiss-Prot: CLC4K_HUMAN, Q9UJ71
Function: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck
granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as
mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in
the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells
for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency
virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is
followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation

Gene Wiki entry for CD207 (Langerin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD207 gene promoter:
         AML1a   FOXD3   Nkx5-1   HNF-3beta   Meis-1b   SRY   Meis-1a   LyF-1   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD207 promoter sequence
   Search Chromatin IP Primers for CD207

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD207


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13

CD207 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD207 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M071057:  view genomic region     (about GC identifiers)

Start:
71,057,343 bp from pter      End:
71,062,953 bp from pter
Size:
5,611 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CLC4K_HUMAN, Q9UJ71 (See protein sequence)
Recommended Name: C-type lectin domain family 4 member K  
Size: 328 amino acids; 36725 Da
Subunit: Homotrimer
Selected PDB 3D structures from and Proteopedia for CD207 (see all 19):
3C22 (3D)        3KQG (3D)        3P5D (3D)        3P5E (3D)        3P5F (3D)        3P5G (3D)    

Explore the universe of human proteins at neXtProt for CD207: NX_Q9UJ71

Explore proteomics data for CD207 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn87, Asn113, Asn180

  • See CD207 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056532.4  
    ENSEMBL proteins: 
     ENSP00000386378  
    Reactome Protein details: Q9UJ71

    CD207 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD207 (Langerin/CD207)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD207
    OriGene Protein Over-expression Lysate for CD207
    OriGene MassSpec for CD207
    OriGene Custom Protein Services for CD207
    GenScript Custom Purified and Recombinant Proteins Services for CD207
    Novus Biologicals CD207 Proteins
    Novus Biologicals CD207 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD207 

     
    antibodies-online proteins for CD207 (5 products) 

     
    antibodies-online peptides for CD207

    CD207 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD207 (Langerin/CD207)
    Cell Signaling Technology (CST) Antibodies for CD207  (langerin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CD207
    Novus Biologicals CD207 Antibodies
    Search for Antibodies for CD207 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD207
    antibodies-online antibodies for CD207 (118 products) 

    CD207 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD207
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD207
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD207 
    antibodies-online kits for CD207 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    4 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9UJ71

    ProtoNet protein and cluster: Q9UJ71

    UniProtKB/Swiss-Prot: CLC4K_HUMAN, Q9UJ71
    Domain: The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CD207           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLC4K_HUMAN, Q9UJ71
    Function: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck
    granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as
    mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in
    the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells
    for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency
    virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is
    followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005537mannose binding TAS10661407
    GO:0030246carbohydrate binding IDA--
         
    Find genes that share ontologies with CD207           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD207:
     Decreased Wnt reporter activit  Increased G1 DNA content  Increased HPV18 LCR reporter a  Low eccentricity cells 

         3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cd207):
     hematopoietic system  immune system  no phenotypic analysis 

    Find genes that share phenotypes with CD207           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD207: Cd207tm1Mal Cd207tm1.1Cfg

       genOway: Develop your customized and physiologically relevant rodent model for CD207

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD207 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD207:
    hsa-miR-146a* hsa-miR-4310 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCD207 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD207
    Predesigned siRNA for gene silencing in human, mouse, rat CD207

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD207

    Clone
    Products:
         
    OriGene clones in human, mouse for CD207 (see all 7)
    OriGene ORF clones in mouse, rat for CD207
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD207 (NM_015717)
    Sino Biological Human cDNA Clone for CD207
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD207
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD207

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD207
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD207 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD207

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10268) for CD207 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CLC4K_HUMAN, Q9UJ71: Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which
    are organelles consisting of superimposed and zippered membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome4
    plasma membrane4
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030139endocytic vesicle TAS10661407
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--

    Find genes that share ontologies with CD207           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CD207 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Cross-presentation of soluble exogenous antigens (endosomes)0.80


    Find genes that share SuperPaths with CD207           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD207
        Cross-presentation of soluble exogenous antigens (endosomes)


        Pathway & Disease-focused RT2 Profiler PCR Array including CD207: 
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD207

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I TAS--
    GO:0051607defense response to virus IDA17334373

    Find genes that share ontologies with CD207           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD207 (CLC4K)

    1 HMDB Compound for CD207    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for CD207 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 63.5 15 14722767 (2), 19363450 (1), 12960229 (1), 18061677 (1) (see all 13)
    polysaccharide 19.8 5 20026605 (3), 20181944 (1), 12626394 (1)



    Find genes that share compounds with CD207           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CD207 gene: 
    NM_015717.4  

    Unigene Cluster for CD207:

    CD207 molecule, langerin
    Hs.199731  [show with all ESTs]
    Unigene Representative Sequence: AJ242859
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000410009(uc002shg.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD207 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD207:
    hsa-miR-146a* hsa-miR-4310 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCD207 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD207
    Predesigned siRNA for gene silencing in human, mouse, rat CD207
    Clone
    Products:
         
    OriGene clones in human, mouse for CD207 (see all 7)
    OriGene ORF clones in mouse, rat for CD207
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD207 (NM_015717)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD207
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD207
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD207
    OriGene qSTAR qPCR primer pairs in human, mouse for CD207
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD207
      QuantiTect SYBR Green Assays in human, mouse, rat CD207
      QuantiFast Probe-based Assays in human, mouse, rat CD207
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10268) for CD207 

    Additional mRNA sequence: 

    AJ242859.1 AK314927.1 BC022278.1 

    1 DOTS entry:

    DT.75170264 

    9 AceView cDNA sequences:

    BX104865 BQ300473 AJ242859 AW293796 NM_015717 BC022278 BF511185 AI669693 
    BG539681 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CD207 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCACCTT
    CD207 Expression
    About this image

    CD207 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD207 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199731

    UniProtKB/Swiss-Prot: CLC4K_HUMAN, Q9UJ71
    Tissue specificity: Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma,
    but not in normal brain tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including CD207: 
              Antifungal Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD207
    OriGene qSTAR qPCR primer pairs in human, mouse for CD207
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD207
    QuantiTect SYBR Green Assays in human, mouse, rat CD207
    QuantiFast Probe-based Assays in human, mouse, rat CD207
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD207

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CD207 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2071 , 5 CD207 antigen1, 5 75.26(n)1
    67.7(a)1
      6 (35.94 cM)5
    2462781  NM_144943.31  NP_659192.21 
     836712075 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    37(a)
    30(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343540.1(119051-134906)
    GL343830.1(152731-155973)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017309841 uncharacterized LOC101730984 51.91(n)
    45.08(a)
      101730984  XM_004918850.1  XP_004918907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD2076
    CD207 molecule, langerin
    21(a)
    1 → many
    8(41685924-41692286) ENSDARG00000046142


    ENSEMBL Gene Tree for CD207 (if available)
    TreeFam Gene Tree for CD207 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CD207 gene
    CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    2 SIMAP similar genes for CD207 using alignment to 1 protein entry:     CLC4K_HUMAN:
    CLEC4F    CLEC4E

    Find genes that share paralogs with CD207           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CD207 (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0638284
    Birbeck granule deficiency (BIRGD)4--see VAR_0638282 W R mis40--------
    rs2008372701,2
    Cpathogenic171058878(+) GGACCA/GGTCCC 2 R W mis11Minor allele frequency- G:0.00EU 569
    rs15446501,2
    C,F,O,H--71056915(+) GGACCC/TTAATG 1 -- ds500120Minor allele frequency- T:0.13NS EA NA WA CSA 939
    rs15488931,2
    C,F,A,H--71056952(+) CTCCTC/GTCTGT 1 -- ds500114Minor allele frequency- G:0.37NS EA NA WA 926
    rs15446511,2
    C,F,O,H--71057081(+) AGCTAG/TAGACT 1 -- ds500129Minor allele frequency- T:0.27EA NA NS WA CSA 2692
    rs1391382811,2
    --71057092(+) AGAAGA/GTTGTG 1 -- ds50010--------
    rs1143517501,2
    C,F--71057206(+) GGACTG/AGAACT 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1809144491,2
    --71057216(+) TTCCCC/TAGTCC 1 -- ds50010--------
    rs1436701781,2
    --71057224(+) TCCTTA/GTTATT 1 -- ds50010--------
    rs1872182971,2
    C--71057461(+) GAGGAA/GGAGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD207 (71057343 - 71062953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CD207:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874252CNV Loss21882294

    Human Gene Mutation Database (HGMD): CD207
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD207
    DNA2.0 Custom Variant and Variant Library Synthesis for CD207

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604862   
    OMIM disorders: 613393  
    UniProtKB/Swiss-Prot: CLC4K_HUMAN, Q9UJ71
  • Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck
    granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in
    normal numbers and have normal morphologic characteristics and antigen-presenting capacity. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 9 diseases for CD207:    
    About MalaCards
    allergic conjunctivitis    malignant ependymoma    oral lichen planus    birbeck granule deficiency
    alk+ histiocytosis    langerhans-cell histiocytosis    langerhans cell sarcoma    histiocytosis
    idiopathic pulmonary fibrosis

    2 diseases from the University of Copenhagen DISEASES database for CD207:
    Langerhans cell sarcoma     Langerhans-cell histiocytosis

    Find genes that share disorders with CD207           About GenesLikeMe

    7 Novoseek inferred disease relationships for CD207 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    langerhans cell histiocytosis 78.7 17 18277880 (7), 14722767 (2), 17527085 (1), 18029555 (1) (see all 6)
    histiocytosis 66.9 1 17378241 (1)
    sarcoma 35.5 6 20439325 (3), 18029555 (1), 18277880 (1), 18360746 (1)
    infectious disease 0.852 3 17527085 (1), 18805593 (1), 14991068 (1)
    necrosis 0 2 12186835 (1)
    tumors 0 7 12186835 (1), 16243135 (1), 15914364 (1), 18805873 (1)
    immunodeficiency 0 2 20181944 (1), 19224860 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD207 (1 document)

    Export disorders for CD207 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CD207 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with CD207)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. (PubMed id 10661407)1, 2, 3, 9 Valladeau J.... Saeland S. (Immunity 2000)
    2. Polymorphisms in human langerin affect stability and sugar binding activity. (PubMed id 16567809)1, 2, 9 Ward E.M.... Taylor M.E. (J. Biol. Chem. 2006)
    3. Dual specificity of langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain. (PubMed id 20026605)1, 2, 9 Tateno H.... Hirabayashi J. (J. Biol. Chem. 2010)
    4. C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. (PubMed id 20097424)1, 2, 9 de Jong M.A.... Geijtenbeek T.B. (Mol. Immunol. 2010)
    5. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. (PubMed id 17334373)1, 2, 9 de Witte L.... Geijtenbeek T.B. (Nat. Med. 2007)
    6. Langerin/CD207 sheds light on formation of Birbeck granules and their possible function in Langerhans cells. (PubMed id 14610287)1, 2, 9 Valladeau J.... Saeland S. (Immunol. Res. 2003)
    7. A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. (PubMed id 15816828)1, 2, 9 Verdijk P.... Tensen C.P. (J. Invest. Dermatol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Toward a complete human genome sequence. (PubMed id 9847074)1, 3 Sulston J.E. and Waterston R. (Genome Res. 1998)
    10. Immunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. (PubMed id 18277880)1, 9 Lau S.K....Weiss L.M. (Am. J. Surg. Pathol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 50489 HGNC: 17935 AceView: CD207 Ensembl:ENSG00000116031 euGenes: HUgn50489
    ECgene: CD207 H-InvDB: CD207

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CD207 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_00126

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CD207 gene:
    Search GeneIP for patents involving CD207

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CD207 (Langerin/CD207)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CD207 (Langerin/CD207)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CD207  
     OriGene qPCR primer pairs and template standards for CD207   OriGene Protein Over-expression Lysate for CD207  
     OriGene MassSpec for CD207   OriGene clones in human, mouse for CD207  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD207   OriGene Purified Protein for CD207  
     OriGene ORF clones in mouse, rat for CD207   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD207   OriGene Custom Protein Services for CD207  

     
     
     Block miRNA regulation of human, mouse, rat CD207 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CD207
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD207 Predesigned siRNA for gene silencing in human, mouse, rat CD207
     QuantiFast Probe-based Assays in human, mouse, rat CD207 QuantiTect SYBR Green Assays in human, mouse, rat CD207
     PCR Arrays including human, mouse, rat CD207 Search Chromatin IP Primers for CD207
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD207  GeneGlobe Interaction Network for CD207
     Regulatory tfbs in CD207 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CD207 GenScript cDNA clones with any tag delivered in your preferred vector for CD207
     GenScript Custom Assay Services for CD207 GenScript Custom overexpressing Cell Line Services for CD207
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CD207  (langerin)

     Search Tocris compounds for CD207 (CLC4K)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CD207
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CD207 antibodies
     CD207 proteins
     CD207 lysates
     Search for Antibodies for CD207 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CD207
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CD207
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD207
     SwitchGear 3'UTR luciferase reporter plasmids for CD207
     SwitchGear Promoter luciferase reporter plasmids for CD207
     ThermoFisher Antibodies for CD207
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD207
     Browse compounds at ApexBio
     Search Addgene for plasmids for CD207
      Search eBioscience for proteins for CD207
      Search eBioscience for elisas for CD207
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CD207
     antibodies-online antibodies for CD207 (118 products)
     antibodies-online kits for CD207 (5 products)
     antibodies-online peptides for CD207
     antibodies-online proteins for CD207 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD207 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4