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CD200R1L Gene

protein-coding   GIFtS: 42
GCID: GC03M112534

CD200 Receptor 1-Like

  See CD200R1L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD200 Receptor 1-Like1 2     CD200 Cell Surface Glycoprotein Receptor-Like A2 3
CD200 Receptor 21 2     CD200 Receptor-Like 22 3
Cell Surface Glycoprotein CD200 Receptor 1-Like2 3     CD200 Cell Surface Glycoprotein Receptor 22
Cell Surface Glycoprotein OX2 Receptor 22 3     Cell Surface Glycoprotein CD200 Receptor 22
CD200R22 3     huCD200R22
CD200RLa2 3     HuCD200R23
CD200 Cell Surface Glycoprotein Receptor-Like 22 3     

External Ids:    HGNC: 246651   Entrez Gene: 3448072   Ensembl: ENSG000002065317   UniProtKB: Q6Q8B33   

Export aliases for CD200R1L gene to outside databases

Previous GC identifers: GC03M114017 GC03M109917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD200R1L Gene:
CD200R1L (CD200 receptor 1-like) is a protein-coding gene. Diseases associated with CD200R1L include sleeping sickness. An important paralog of this gene is CD200R1.

UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3
Function: May be a receptor for the CD200/OX2 cell surface glycoprotein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD200R1L gene promoter:
         Brachyury   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD200R1L promoter sequence
   Search Chromatin IP Primers for CD200R1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD200R1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

CD200R1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD200R1L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112534:  view genomic region     (about GC identifiers)

Start:
112,534,556 bp from pter      End:
112,565,703 bp from pter
Size:
31,148 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3 (See protein sequence)
Recommended Name: Cell surface glycoprotein CD200 receptor 2 precursor  
Size: 271 amino acids; 29920 Da
Secondary accessions: Q6WHB7
Alternative splicing: 2 isoforms:  Q6Q8B3-1   Q6Q8B3-2   

Explore the universe of human proteins at neXtProt for CD200R1L: NX_Q6Q8B3

Explore proteomics data for CD200R1L at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30, Asn39, Asn86, Asn92, Asn189, Asn217

  • See CD200R1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008784.2  NP_001186144.1  

    ENSEMBL proteins: 
     ENSP00000381272   ENSP00000418413   ENSP00000420461   ENSP00000415132  

    CD200R1L Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for CD200R1L
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD200R1L 

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    Search eBioscience for ELISAs for CD200R1L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing

    3 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6Q8B3

    ProtoNet protein and cluster: Q6Q8B3

    UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3
    Similarity: Belongs to the CD200R family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD200R1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO2R2_HUMAN, Q6Q8B3
    Function: May be a receptor for the CD200/OX2 cell surface glycoprotein (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CD200R1L           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD200R1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD200R1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD200R1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD200R1L

    miRNA
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    Block miRNA regulation of human, mouse, rat CD200R1L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CD200R1L:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidCD200R1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD200R1L
    Predesigned siRNA for gene silencing in human, mouse, rat CD200R1L

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for CD200R1L
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200R1L

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MO2R2_HUMAN, Q6Q8B3: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CD200R1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD200R1L
    Interactions:

        Search GeneGlobe Interaction Network for CD200R1L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD200R1L (ENSP000003812724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPENSP000002626294STRING: ENSP00000262629
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD200R1L (MO2R2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD200R1L gene (2 alternative transcripts): 
    NM_001008784.2  NM_001199215.1  

    Unigene Cluster for CD200R1L:

    CD200 receptor 1-like
    Hs.531814  [show with all ESTs]
    Unigene Representative Sequence: AY284976
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398214(uc003dzi.1) ENST00000488794 ENST00000486723(uc011bhw.1)
    ENST00000448932(uc010hqf.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD200R1L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CD200R1L:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidCD200R1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD200R1L
    Predesigned siRNA for gene silencing in human, mouse, rat CD200R1L
    Clone
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    OriGene clones in human, mouse for CD200R1L (see all 6)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD200R1L (NM_001008784)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200R1L
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD200R1L
      QuantiTect SYBR Green Assays in human, mouse, rat CD200R1L
      QuantiFast Probe-based Assays in human, mouse, rat CD200R1L

    Additional mRNA sequence: 

    AY284976.1 AY552790.1 BC144504.1 

    2 DOTS entries:

    DT.97777445  DT.102820663 

    4 AceView cDNA sequences:

    AY552790 AY284976 BQ438707 AA629393 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD200R1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTCCCT
    CD200R1L Expression
    About this image


    CD200R1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    CD200R1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD200R1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531814
        Custom PCR Arrays for CD200R1L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD200R1L gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd200r21 , 5 Cd200 receptor 21, 5 69.09(n)1
    56.36(a)1
      16 (29.17 cM)5
    2713751  NM_206535.11  NP_996258.11 
     448670975 
    chicken
    (Gallus gallus)
    Aves CD200R1L6
    CD200R1A6
    Gallus gallus CD200 receptor 1 (CD200R1), mRNA.
    30(a)
    25(a)
    many ↔ many
    many ↔ many
    1(82814196-82818802)
    1(82841597-82864019)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    1 → many
    3(175924347-175944837)


    ENSEMBL Gene Tree for CD200R1L (if available)
    TreeFam Gene Tree for CD200R1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD200R1L gene
    CD200R12  
    1 SIMAP similar gene for CD200R1L using alignment to 2 protein entries:     MO2R2_HUMAN (see all proteins):
    CD200R1

    Find genes that share paralogs with CD200R1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD200R1L (see all 557)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820576431,2
    --112539316(+) ATTGTC/TTCTCA 2 -- int10--------
    rs1869589261,2
    --112539329(+) CTCTAC/GTGCAG 2 -- int10--------
    rs596055481,2
    F--112539339(+) GCGGCG/ACAATC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1898064511,2
    --112539418(+) GATTAC/TAGGCA 2 -- int10--------
    rs1130138381,2
    C,F--112539726(+) ATGGTA/GAAACC 2 -- int11Minor allele frequency- G:0.00WA 2
    rs130644751,2
    C,F--112539761(+) TAGCCA/GAGCGT 2 -- int19Minor allele frequency- G:0.44NA WA CSA EA 369
    rs1471518621,2
    --112539765(+) CGAGCA/GTGGTG 2 -- int10--------
    rs130644961,2
    C,F--112539797(+) TACTCA/GGGAGG 2 -- int15Minor allele frequency- G:0.20NA CSA 10
    rs130642681,2
    C,F--112539851(+) GTGAGT/CTGAGA 2 -- int16Minor allele frequency- C:0.17NA CSA 12
    rs1130434981,2
    C--112539859(+) AGATTG/TCACCA 2 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for CD200R1L (112534556 - 112565703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD200R1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673110CNV Deletion23128226
    esv274142CNV Insertion20981092
    nsv877343CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD200R1L
    DNA2.0 Custom Variant and Variant Library Synthesis for CD200R1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CD200R1L:    
    About MalaCards
    sleeping sickness

    1 disease from the University of Copenhagen DISEASES database for CD200R1L:
    Sleeping sickness

    Find genes that share disorders with CD200R1L           About GenesLikeMe

    Genetic Association Database (GAD): CD200R1L

    Export disorders for CD200R1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD200R1L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CD200R1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)1, 2 Wright G.J....Barclay A.N. (J. Immunol. 2003)
    2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
    3. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? (PubMed id 16928187)1 Minas K. and Liversidge J. (Crit. Rev. Immunol. 2006)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    5. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. (PubMed id 15471863)1 Voehringer D....Locksley R.M. (J. Biol. Chem. 2004)
    6. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PubMed id 15274657)2 Gorczynski R.M.... Marsden P. (Am. J. Reprod. Immunol. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 344807 HGNC: 24665 AceView: LOC344807 Ensembl:ENSG00000206531 euGenes: HUgn344807
    ECgene: CD200R1L H-InvDB: CD200R1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD200R1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD200R1L gene:
    Search GeneIP for patents involving CD200R1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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