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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD200R1L Gene

protein-coding   GIFtS: 41
GCID: GC03M112534

CD200 Receptor 1-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD200 Receptor 1-Like1 2     CD200 Cell Surface Glycoprotein Receptor-Like A2 3
CD200 Receptor 21 2     CD200 Receptor-Like 22 3
Cell Surface Glycoprotein CD200 Receptor 1-Like2 3     CD200 Cell Surface Glycoprotein Receptor 22
Cell Surface Glycoprotein OX2 Receptor 22 3     Cell Surface Glycoprotein CD200 Receptor 22
CD200R22 3     huCD200R22
CD200RLa2 3     HuCD200R23
CD200 Cell Surface Glycoprotein Receptor-Like 22 3     

External Ids:    HGNC: 246651   Entrez Gene: 3448072   Ensembl: ENSG000002065317   UniProtKB: Q6Q8B33   

Export aliases for CD200R1L gene to outside databases

Previous GC identifers: GC03M114017 GC03M109917


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CD200R1L Gene: 
CD200R1L (CD200 receptor 1-like) is a protein-coding gene. Diseases associated with CD200R1L include sleeping sickness. An important paralog of this gene is CD200R1.

UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3
Function: May be a receptor for the CD200/OX2 cell surface glycoprotein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD200R1L gene promoter:
         Brachyury   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD200R1L promoter sequence
   Search SABiosciences Chromatin IP Primers for CD200R1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD200R1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

CD200R1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD200R1L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112534:  view genomic region     (about GC identifiers)

Start:
112,534,556 bp from pter      End:
112,565,703 bp from pter
Size:
31,148 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3 (See protein sequence)
Recommended Name: Cell surface glycoprotein CD200 receptor 2 precursor  
Size: 271 amino acids; 29920 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q6WHB7
Alternative splicing: 2 isoforms:  Q6Q8B3-1   Q6Q8B3-2   

Explore the universe of human proteins at neXtProt for CD200R1L: NX_Q6Q8B3

Explore proteomics data for CD200R1L at MOPED 

CD200R1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CD200R1L Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001008784.2  NP_001186144.1  

ENSEMBL proteins: 
 ENSP00000381272   ENSP00000418413   ENSP00000420461   ENSP00000415132  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

CD200R1L for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
C2SET: Immunoglobulin superfamily / C2-set domain containing

3 InterPro protein domains:
 IPR013162 CD80_C2-set
 IPR013783 Ig-like_fold
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q6Q8B3

ProtoNet protein and cluster: Q6Q8B3

UniProtKB/Swiss-Prot: MO2R2_HUMAN, Q6Q8B3
Similarity: Belongs to the CD200R family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


CD200R1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MO2R2_HUMAN, Q6Q8B3
Function: May be a receptor for the CD200/OX2 cell surface glycoprotein (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
CD200R1L for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD200R1L

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CD200R1L (ENSP000003812724) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TYROBPENSP000002626294STRING: ENSP00000262629
CD200ENSP000004202984STRING: ENSP00000420298
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD200R1L (MO2R2)

Search CenterWatch for drugs/clinical trials and news about CD200R1L / MO2R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD200R1L gene (2 alternative transcripts): 
NM_001008784.2  NM_001199215.1  

Unigene Cluster for CD200R1L:

CD200 receptor 1-like
Hs.531814  [show with all ESTs]
Unigene Representative Sequence: AY284976
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000398214(uc003dzi.1) ENST00000488794 ENST00000486723(uc011bhw.1)
ENST00000448932(uc010hqf.1)
miRNA
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hsa-miR-548p
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Inhib. RNA
Products:
     
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Additional mRNA sequence: 

AY284976.1 AY552790.1 BC144504.1 

2 DOTS entries:

DT.97777445  DT.102820663 

4 AceView cDNA sequences:

AY552790 AY284976 BQ438707 AA629393 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD200R1L expression in normal human tissues (normalized intensities)      CD200R1L embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGTTTCCCT
CD200R1L Expression
About this image


CD200R1L expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 5 entries
         ganglion/cranial/facial VII   
 
 Spinal Cord (Nervous System)
         spinal/ganglion/dorsal root ganglion   
 
 Peripheral Nervous System (Nervous System)
         spinal/ganglion/dorsal root ganglion   
 
 Nose (Sensory Organs)
         sensory organ/nose/nasal cavity   
 
 Eye (Sensory Organs)
         Retina

See CD200R1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531814
    SABiosciences Custom PCR Arrays for CD200R1L
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD200R1L
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1L gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cd200r21 , 5 Cd200 receptor 21, 5 68.94(n)1
56.36(a)1
  16 (29.17 cM)5
2713751  NM_206535.11  NP_996258.11 
 448670975 
chicken
(Gallus gallus)
Aves CD200R16
CD200R1A6
Cell surface glycoprotein CD200 receptor 1-A
30(a)
25(a)
many ↔ many
many ↔ many
1(82814196-82818802)
1(82841597-82864019)
lizard
(Anolis carolinensis)
Reptilia --
--
21(a)
1 → many
3(175924347-175944837)
zebrafish
(Danio rerio)
Actinopterygii CD200R1L6
CD200 receptor 1-like
15(a)
1 → many
9(9632421-9641116)


ENSEMBL Gene Tree for CD200R1L (if available)
TreeFam Gene Tree for CD200R1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CD200R1L gene
CD200R12  
1 SIMAP similar gene for CD200R1L using alignment to 2 protein entries:     MO2R2_HUMAN (see all proteins):
CD200R1

CD200R1L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/557 SNPs in CD200R1L are shown (see all 557)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1820576431,2
--112539316(+) ATTGTC/TTCTCA 2 -- int10--------
rs1869589261,2
--112539329(+) CTCTAC/GTGCAG 2 -- int10--------
rs596055481,2
F--112539339(+) GCGGCG/ACAATC 2 -- int11Minor allele frequency- A:0.03WA 118
rs1898064511,2
--112539418(+) GATTAC/TAGGCA 2 -- int10--------
rs1130138381,2
C,F--112539726(+) ATGGTA/GAAACC 2 -- int11Minor allele frequency- G:0.00WA 2
rs130644751,2
C,F--112539761(+) TAGCCA/GAGCGT 2 -- int19Minor allele frequency- G:0.44NA WA CSA EA 369
rs1471518621,2
--112539765(+) CGAGCA/GTGGTG 2 -- int10--------
rs130644961,2
C,F--112539797(+) TACTCA/GGGAGG 2 -- int15Minor allele frequency- G:0.20NA CSA 10
rs130642681,2
C,F--112539851(+) GTGAGT/CTGAGA 2 -- int16Minor allele frequency- C:0.17NA CSA 12
rs1130434981,2
C--112539859(+) AGATTG/TCACCA 2 -- int11Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for CD200R1L (112534556 - 112565703 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CD200R1L:    About this table     
Variant IDTypeSubtypePubMed ID
esv2673110CNV Deletion23128226
esv274142CNV Insertion20981092
nsv877343CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for CD200R1L:    About MalaCards
sleeping sickness    

1 disease from the University of Copenhagen DISEASES database for CD200R1L:
Sleeping sickness

CD200R1L for disorders           About GeneDecksing

Genetic Association Database (GAD): CD200R1L

Export disorders for CD200R1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CD200R1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with CD200R1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)1, 2 Wright G.J....Barclay A.N. (2003)
  2. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
  3. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? (PubMed id 16928187)1 Minas K. and Liversidge J. (2006)
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
  5. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. (PubMed id 15471863)1 Voehringer D....Locksley R.M. (2004)
  6. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PubMed id 15274657)2 Gorczynski R.M....Marsden P. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 344807 HGNC: 24665 AceView: LOC344807 Ensembl:ENSG00000206531 euGenes: HUgn344807
ECgene: CD200R1L H-InvDB: CD200R1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CD200R1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CD200R1L gene:
Search GeneIP for patents involving CD200R1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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