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Aliases for CD200R1L Gene

Aliases for CD200R1L Gene

  • CD200 Receptor 1 Like 2 3 5
  • Cell Surface Glycoprotein CD200 Receptor 1-Like 3 4
  • CD200 Cell Surface Glycoprotein Receptor-Like 2 3 4
  • CD200 Cell Surface Glycoprotein Receptor-Like A 3 4
  • Cell Surface Glycoprotein OX2 Receptor 2 3 4
  • CD200 Receptor-Like 2 3 4
  • CD200 Receptor 2 2 3
  • HuCD200R2 3 4
  • CD200RLa 3 4
  • CD200R2 3 4
  • CD200 Cell Surface Glycoprotein Receptor 2 3
  • Cell Surface Glycoprotein CD200 Receptor 2 3
  • CD200 Receptor 1-Like 2

External Ids for CD200R1L Gene

Previous GeneCards Identifiers for CD200R1L Gene

  • GC03M114017
  • GC03M112534
  • GC03M109917

Summaries for CD200R1L Gene

GeneCards Summary for CD200R1L Gene

CD200R1L (CD200 Receptor 1 Like) is a Protein Coding gene. An important paralog of this gene is CD200R1.

UniProtKB/Swiss-Prot for CD200R1L Gene

  • May be a receptor for the CD200/OX2 cell surface glycoprotein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200R1L Gene

Genomics for CD200R1L Gene

Regulatory Elements for CD200R1L Gene

Enhancers for CD200R1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F112773 1.4 FANTOM5 Ensembl ENCODE 10.1 +69.5 69492 8.0 HDGF PKNOX1 ZBTB40 ETV6 FOS CREM SMARCC1 SMAD5 CBFB CEBPB CD200R1 ENSG00000242770 CD200R1L ATG3 LINC02042
GH03F112089 1.2 Ensembl ENCODE 11.6 +755.1 755108 3.6 INSM2 KLF17 FEZF1 GLIS2 ZNF366 SCRT2 ZNF391 FOS ZNF362 SP3 ENSG00000261488 LINC02042 ENSG00000239311 MIR567 CD200R1L PLCXD2-AS1 ABHD10 C3orf52 GC03P112114
GH03F112810 1.1 Ensembl ENCODE 10.9 +34.1 34087 4.0 CTCF HINFP TAL1 ETV1 MAX RAD21 ZNF316 CBX5 NCOR1 SMC3 CD200R1 CD200R1L GTPBP8 ENSG00000242770
GH03F112817 1.1 FANTOM5 Ensembl ENCODE 10.9 +28.6 28590 1.8 ZNF316 CEBPB NFE2 FOS MAFK NFE2L2 CD200R1 CD200R1L ATG3 SLC35A5 ENSG00000242770
GH03F112766 1.1 FANTOM5 Ensembl ENCODE 10.1 +79.7 79685 1.2 IKZF1 CEBPB SPI1 ENSG00000242770 CD200R1L CD200R1 ATG3 LINC02042
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD200R1L on UCSC Golden Path with GeneCards custom track

Genomic Location for CD200R1L Gene

Chromosome:
3
Start:
112,812,239 bp from pter
End:
112,846,889 bp from pter
Size:
34,651 bases
Orientation:
Minus strand

Genomic View for CD200R1L Gene

Genes around CD200R1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200R1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200R1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200R1L Gene

Proteins for CD200R1L Gene

  • Protein details for CD200R1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q8B3-MO2R2_HUMAN
    Recommended name:
    Cell surface glycoprotein CD200 receptor 2
    Protein Accession:
    Q6Q8B3
    Secondary Accessions:
    • Q6WHB7

    Protein attributes for CD200R1L Gene

    Size:
    271 amino acids
    Molecular mass:
    29920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD200R1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200R1L Gene

Post-translational modifications for CD200R1L Gene

  • Glycosylation at Asn 30, Asn 39, Asn 86, Asn 92, Asn 189, and Asn 217
  • Modification sites at PhosphoSitePlus

Other Protein References for CD200R1L Gene

No data available for DME Specific Peptides for CD200R1L Gene

Domains & Families for CD200R1L Gene

Gene Families for CD200R1L Gene

Protein Domains for CD200R1L Gene

Suggested Antigen Peptide Sequences for CD200R1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6Q8B3

UniProtKB/Swiss-Prot:

MO2R2_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the CD200R family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD200R family.
genes like me logo Genes that share domains with CD200R1L: view

Function for CD200R1L Gene

Molecular function for CD200R1L Gene

UniProtKB/Swiss-Prot Function:
May be a receptor for the CD200/OX2 cell surface glycoprotein.

Gene Ontology (GO) - Molecular Function for CD200R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with CD200R1L: view

Phenotypes for CD200R1L Gene

GenomeRNAi human phenotypes for CD200R1L:
genes like me logo Genes that share phenotypes with CD200R1L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD200R1L Gene

Localization for CD200R1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200R1L Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD200R1L gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD200R1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD200R1L: view

Pathways & Interactions for CD200R1L Gene

SuperPathways for CD200R1L Gene

No Data Available

Interacting Proteins for CD200R1L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381272%0d%0a9606.ENSP00000420298%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000381272 Q6Q8B3-MO2R2_HUMAN for CD200R1L Gene via STRING IID

Gene Ontology (GO) - Biological Process for CD200R1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CD200R1L Gene

Transcripts for CD200R1L Gene

mRNA/cDNA for CD200R1L Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD200R1L Gene

CD200 receptor 1-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1L Gene

No ASD Table

Relevant External Links for CD200R1L Gene

GeneLoc Exon Structure for
CD200R1L
ECgene alternative splicing isoforms for
CD200R1L

Expression for CD200R1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD200R1L Gene

mRNA differential expression in normal tissues according to GTEx for CD200R1L Gene

This gene is overexpressed in Testis (x49.3).

NURSA nuclear receptor signaling pathways regulating expression of CD200R1L Gene:

CD200R1L

SOURCE GeneReport for Unigene cluster for CD200R1L Gene:

Hs.531814
genes like me logo Genes that share expression patterns with CD200R1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CD200R1L Gene

Orthologs for CD200R1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD200R1L 34 35
  • 98.52 (n)
mouse
(Mus musculus)
Mammalia Cd200r2 34 35
  • 69.09 (n)
Cd200r4 16 35
  • 46 (a)
Cd200r1 35
  • 36 (a)
ManyToMany
Cd200r3 35
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd200r1l 34
  • 65.95 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
ManyToMany
CD200R1 35
  • 36 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves CD200R1L 35
  • 30 (a)
ManyToMany
CD200R1A 35
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
OneToMany
Species where no ortholog for CD200R1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD200R1L Gene

ENSEMBL:
Gene Tree for CD200R1L (if available)
TreeFam:
Gene Tree for CD200R1L (if available)

Paralogs for CD200R1L Gene

Paralogs for CD200R1L Gene

(1) SIMAP similar genes for CD200R1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD200R1L: view

Variants for CD200R1L Gene

Sequence variations from dbSNP and Humsavar for CD200R1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10511314 -- 112,834,109(-) GATAT(C/G)ATTTC intron-variant
rs10597421 -- 112,826,151(+) ATTAT(-/AT)TTAAT intron-variant
rs10715617 -- 112,821,652(+) TGGTG(-/T)TTTTT intron-variant
rs10804504 -- 112,830,693(+) GAAAA(C/T)GAAAA intron-variant
rs10934188 -- 112,821,421(+) TATTC(C/T)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD200R1L Gene

Variant ID Type Subtype PubMed ID
nsv965198 CNV duplication 23825009
nsv591293 CNV loss 21841781
esv3597424 CNV loss 21293372
esv3597423 CNV loss 21293372
esv3597422 CNV gain 21293372
esv3597421 CNV gain 21293372
esv3432979 CNV insertion 20981092
esv3406446 CNV insertion 20981092
esv3309870 CNV mobile element insertion 20981092
esv2673110 CNV deletion 23128226

Variation tolerance for CD200R1L Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD200R1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD200R1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200R1L Gene

Disorders for CD200R1L Gene

Relevant External Links for CD200R1L

Genetic Association Database (GAD)
CD200R1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD200R1L

No disorders were found for CD200R1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD200R1L Gene

Publications for CD200R1L Gene

  1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PMID: 12960329) Wright G.J. … Barclay A.N. (J. Immunol. 2003) 3 4 64
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 64
  3. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? (PMID: 16928187) Minas K. … Liversidge J. (Crit. Rev. Immunol. 2006) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. (PMID: 15471863) Voehringer D. … Locksley R.M. (J. Biol. Chem. 2004) 3 64

Products for CD200R1L Gene

Sources for CD200R1L Gene

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