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CD200R1 Gene

protein-coding   GIFtS: 58
GCID: GC03M112640

CD200 Receptor 1

(Previous name: MOX2 receptor)
(Previous symbol: MOX2R)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD200 Receptor 11 2     CD200 Cell Surface Glycoprotein Receptor2 3
MOX2R1 2 3 5     HCRTR22
OX2R2 3 5     Cell Surface Glycoprotein CD200 Receptor 12
MOX2 Receptor1 2     Cell Surface Glycoprotein Receptor CD2002
Cell Surface Glycoprotein OX2 Receptor 12 3     CRTR23
CD200R2 3     

External Ids:    HGNC: 242351   Entrez Gene: 1314502   Ensembl: ENSG000001636067   OMIM: 6075465   UniProtKB: Q8TD463   

Export aliases for CD200R1 gene to outside databases

Previous GC identifers: GC03M114122 GC03M110025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD200R1 Gene:
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface
glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid
lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse
studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD200R1 Gene:
CD200R1 (CD200 receptor 1) is a protein-coding gene. Diseases associated with CD200R1 include smoldering myeloma, and cerebritis. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
Function: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with
identical affinity and kinetics as the host CD200

summary for CD200R1 Gene:
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex,
paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are
thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B.
The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

Gene Wiki entry for CD200R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD200R1 gene promoter:
         AhR   LHX3b/Lhx3b   ISGF-3   Sp1   FOXD3   Cdc5   Gfi-1   MEF-2A   AREB6   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD200R1 promoter sequence
   Search Chromatin IP Primers for CD200R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD200R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13

CD200R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD200R1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112640:  view genomic region     (about GC identifiers)

Start:
112,640,056 bp from pter      End:
112,693,969 bp from pter
Size:
53,914 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46 (See protein sequence)
Recommended Name: Cell surface glycoprotein CD200 receptor 1 precursor  
Size: 325 amino acids; 36620 Da
Subunit: Interacts with Human herpesvirus 8 vOX2 protein
Secondary accessions: B3KWZ9 E9PCM9 Q52LJ7 Q6IS95 Q6UW94 Q6WHB8 Q8TD44 Q8TD45 Q8TD52
Alternative splicing: 4 isoforms:  Q8TD46-1   Q8TD46-2   Q8TD46-3   Q8TD46-4   

Explore the universe of human proteins at neXtProt for CD200R1: NX_Q8TD46

Explore proteomics data for CD200R1 at MOPED

Post-translational modifications: 

  • The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform1
  • Glycosylation2 at Asn37, Asn46, Asn93, Asn99, Asn162, Asn195, Asn210, Asn224
  • Modification sites at PhosphoSitePlus

  • See CD200R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_620161.1  NP_620385.1  NP_620386.1  NP_740750.1  

    ENSEMBL proteins: 
     ENSP00000418928   ENSP00000311035   ENSP00000295863   ENSP00000405733   ENSP00000418801  
    Reactome Protein details: Q8TD46

    CD200R1 Human Recombinant Protein Products:

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    CD200R1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing

    4 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8TD46

    ProtoNet protein and cluster: Q8TD46

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
    Similarity: Belongs to the CD200R family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD200R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO2R1_HUMAN, Q8TD46
    Function: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with
    identical affinity and kinetics as the host CD200

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CD200R1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD200R1:
     Increased homologous recombina 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd200r1):
     immune system  mortality/aging  no phenotypic analysis 

    CD200R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD200R1: Cd200r1tm1.1Rmgo Cd200r1tm1Eakj

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD200R1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD200R1
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    hsa-miR-98 hsa-let-7d hsa-miR-526b hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidCD200R1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD200R1

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    Sino Biological Human cDNA Clone for CD200R1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200R1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MO2R1_HUMAN, Q8TD46: Isoform 1: Cell membrane; Single-pass type I membrane protein
    MO2R1_HUMAN, Q8TD46: Isoform 4: Cell membrane; Single-pass type I membrane protein
    MO2R1_HUMAN, Q8TD46: Isoform 2: Secreted
    MO2R1_HUMAN, Q8TD46: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    CD200R1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD200R1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD200R1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell



    CD200R1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD200R1
    Interactions:

        GeneGlobe Interaction Network for CD200R1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD200R1 (Q8TD461, 3 ENSP000003110354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD200P412171, 3, ENSP000004202984EBI-4314412,EBI-3910563 I2D: score=3 STRING: ENSP00000420298
    TYROBPO439143, ENSP000002626294I2D: score=1 STRING: ENSP00000262629
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0050776regulation of immune response TAS--

    CD200R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CD200R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist [532932-99-3]
    EMPAHighly potent and selective OX2 antagonist; brain penetrant[680590-49-2]
    TCS OX2 29Potent and selective OX2 antagonist[372523-75-6]
    JNJ 10397049Selective OX2 receptor antagonist[708275-58-5]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD200R1 gene (4 alternative transcripts): 
    NM_138806.3  NM_138939.2  NM_138940.2  NM_170780.2  

    Unigene Cluster for CD200R1:

    CD200 receptor 1
    Hs.309158  [show with all ESTs]
    Unigene Representative Sequence: AK126349
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471858(uc003dzk.1 uc011bhx.1) ENST00000308611(uc003dzj.1 uc003dzl.1 uc003dzm.1)
    ENST00000295863 ENST00000440122 ENST00000490004
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD200R1 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-miR-526b hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidCD200R1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CD200R1
      QuantiFast Probe-based Assays in human, mouse, rat CD200R1

    Additional mRNA sequence: 

    AF283760.1 AF495380.1 AF497548.1 AF497549.1 AF497550.1 AK126349.1 AK293071.1 AK304426.1 
    AY284975.1 AY358910.1 BC069661.1 BC069721.1 BC069743.1 BC093890.1 BC143393.1 

    4 DOTS entries:

    DT.91931497  DT.97763193  DT.100747887  DT.97837493 

    Selected AceView cDNA sequences (see all 26):

    AF497548 NM_138940 AF497549 BC069743 BC069661 NM_170780 AF497550 BC069721 
    AY284975 NM_138806 NM_138939 AF495380 AF283760 BQ045437 AL712200 AY358910 
    AI393580 BQ946922 AL700157 AI867153 AK126349 BE041810 BX497703 BF170532 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -                                                   


    ECgene alternative splicing isoforms for CD200R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD200R1 expression in normal human tissues (normalized intensities)      CD200R1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD200R1 Expression
    About this image


    CD200R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Brain (Nervous System)
             N2/LSB/S/F8-induced cells
    CD200R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD200R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.309158

    UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
    Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK,
    NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord,
    kidney. Expressed in monocyte-derived dendritic and mast cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD200R1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd200r11 , 5 CD200 receptor 11, 5 70.85(n)1
    58.62(a)1
      16 (29.08 cM)5
    577811  NM_021325.31  NP_067300.11 
     447657365 
    chicken
    (Gallus gallus)
    Aves CD200R1L1 CD200 receptor 1-like 56.69(n)
    41.24(a)
      418367  NM_001030782.2  NP_001025953.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    3(175924347-175944837)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017318551 cell surface glycoprotein CD200 receptor 1-like 51.19(n)
    42.86(a)
      101731855  XM_004912440.1  XP_004912497.1 


    ENSEMBL Gene Tree for CD200R1 (if available)
    TreeFam Gene Tree for CD200R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD200R1 gene
    CD200R1L2  
    1 SIMAP similar gene for CD200R1 using alignment to 3 protein entries:     MO2R1_HUMAN (see all proteins):
    CD200R1L

    CD200R1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD200R1
    PGOHUM00000237724


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD200R1 (see all 1080)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357166871,2
    F--110033758(-) ATTACTTAA/-  
            
    GTATA
    3 -- int15Minor allele frequency- -:0.49EU EA NA MN 430
    rs98790051,2
    C,F,A,H--112641046(+) CAAAAG/TAGCTG 2 -- ds500121Minor allele frequency- T:0.45NS EA NA WA CSA 2127
    rs1834200801,2
    --112641076(+) TATGAC/TTGAAG 2 -- ds50010--------
    rs98791491,2
    C,F,A,H--112641092(+) ATATAG/TTTTGT 2 -- ds500124Minor allele frequency- T:0.43NS EA NA WA CSA 2346
    rs1876942651,2
    C--112641138(+) TTTTTC/TTGCTA 2 -- ds50010--------
    rs752865411,2
    C,F--112641201(+) ATGATT/CTACAT 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs767224121,2
    C,F--112641202(+) TGATTT/CACATA 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs798341521,2
    C,F--112641212(+) AAACAT/CTGCCA 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs1905981691,2
    --112641327(+) GGTGCA/GTTTTT 2 -- ds50010--------
    rs1168017371,2
    F--112641333(+) TTTTTC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for CD200R1 (112640056 - 112693969 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD200R1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD200R1
    DNA2.0 Custom Variant and Variant Library Synthesis for CD200R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607546    OMIM disorders: --

    12 diseases for CD200R1:    About MalaCards
    smoldering myeloma    cerebritis    kaposi's sarcoma    multiple sclerosis
    parkinson's disease    myeloma    sarcoma    systemic lupus erythematosus
    lupus erythematosus    alzheimer's disease    squamous cell carcinoma    neuronitis


    CD200R1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CD200R1

    Export disorders for CD200R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD200R1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CD200R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distribution of OX2 antigen and OX2 receptor within retina. (PubMed id 11133863)1, 3, 9 Dick A.D....Wright G.J. (amp 2001)
    2. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)1, 2, 9 Wright G.J....Barclay A.N. (J. Immunol. 2003)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. (PubMed id 10981966)1, 3 Wright G.J....Barclay A.N. (Immunity 2000)
    6. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. (PubMed id 15661892)1, 9 Cherwinski H.M....Phillips J.H. (J. Immunol. 2005)
    7. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PubMed id 15274657)2, 9 Gorczynski R.M.... Marsden P. (Am. J. Reprod. Immunol. 2004)
    8. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PubMed id 19151626)1, 9 Koning N....Huitinga I. (J. Neuropathol. Exp. Neurol. 2009)
    9. Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease. (PubMed id 19924532)1, 9 Luo X.G....Ding J.Q. (Neurochem. Res. 2010)
    10. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. (PubMed id 18164423)1, 9 Meuth S.G....Wiendl H. (J. Neuroimmunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131450 HGNC: 24235 AceView: CD200R1 Ensembl:ENSG00000163606 euGenes: HUgn131450
    ECgene: CD200R1 H-InvDB: CD200R1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD200R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CD200R1 gene:
    Search GeneIP for patents involving CD200R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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