CD200R1 Gene

Aliases
for CD200R1 gene

Previous GC identifers: GC03M114122 GC03M110025

Summaries
for CD200R1 gene

Genomic Views
for CD200R1 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: CD200R1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD200R1

CD200R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112640:  view genomic region     (about GC identifiers)

Proteins
for CD200R1 gene

Explore the universe of human proteins at neXtProt for CD200R1: NX_Q8TD46

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD200R1 (CD200 R1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CD200R1 OriGene Protein Over-expression Lysate (see all 2): CD200R1 OriGene Custom Protein Services for CD200R1
	GenScript Custom Purified and Recombinant Proteins Services for CD200R1
	Novus Biologicals CD200R1 Proteins Novus Biologicals CD200R1 Lysates
	Sino Biological Recombinant Protein for CD200R1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD200R1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD200R1 (CD200 R1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CD200R1
	GenScript Custom Superior Antibodies Services for CD200R1
	Novus Biologicals CD200R1 Antibodies
	Search for Antibodies for CD200R1 at Abcam
	Uscn Antibodies for CD200R1
	ThermoFisher Antibodies for CD200R1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD200R1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD200R1

Protein Domains /
Families
for CD200R1 gene

ProtoNet protein and cluster: Q8TD46

Function
for CD200R1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 4): CD200R1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD200R1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CD200R1 (see all 10):
		hsa-miR-98 hsa-let-7d hsa-miR-526b hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
		SwitchGear 3'UTR luciferase reporter plasmid: CD200R1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD200R1 (see all 7) OriGene shRNA RFP: CD200R1 OriGene siRNA: CD200R1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD200R1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD200R1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD200R1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD200R1 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CD200R1 (NM_138939)
		Sino Biological Human cDNA Clone for CD200R1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200R1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200R1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD200R1
		Search LifeMap BioReagents cell lines for CD200R1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cd200r1)

Pathways & Interactions
for CD200R1 gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Cleavage of Alpha-1-Microglobulin	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.30

3        Reactome Pathways for CD200R1

	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Immune System

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CD200R1 gene

Transcripts
for CD200R1 gene

Expression
for CD200R1 gene

CD200R1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD200R1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD200R1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD200R1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD200R1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1

Orthologs
for CD200R1 gene

Paralogs
for CD200R1 gene

Paralogs for CD200R1 gene

CD200R1L²  

1 SIMAP similar gene for CD200R1 using alignment to 3 protein entries:     MO2R1_HUMAN (see all proteins):

CD200R1L

CD200R1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CD200R1
PGOHUM00000237724

Genomic Variants
for CD200R1 gene

10/920 NCBI SNPs in CD200R1 are shown (see all 920)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs98790051,2	C,F,A,H,	--	112641046(+)	CAAAAG/TAGCTG	2	--	ds5001		21		NS EA NA WA CSA	2127
rs1834200801,2		--	112641076(+)	TATGAC/TTGAAG	2	--	ds5001		0	--	--	--	--
rs98791491,2	C,F,A,H,	--	112641092(+)	ATATAG/TTTTGT	2	--	ds5001		24		NS EA NA WA CSA	2346
rs1876942651,2		--	112641138(+)	TTTTTC/TTGCTA	2	--	ds5001		0	--	--	--	--
rs752865411,2	F,	--	112641201(+)	ATGATT/CTACAT	2	--	ds5001		2		NA EA	240
rs767224121,2	F,	--	112641202(+)	TGATTT/CACATA	2	--	ds5001		2		NA EA	240
rs798341521,2	F,	--	112641212(+)	AAACAT/CTGCCA	2	--	ds5001		2		NA EA	240
rs1905981691,2		--	112641327(+)	GGTGCA/GTTTTT	2	--	ds5001		0	--	--	--	--
rs1168017371,2		--	112641333(+)	TTTTTC/TGCCAC	2	--	ds5001		1		WA	118
rs1999544631,2		--	112641367(+)	TATTC-/AATA           AATAT	2	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD200R1 (112640056 - 112693969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CD200R1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD200R1

DNA2.0 Custom Variant and Variant Library Synthesis for CD200R1

Disorders / Diseases
for CD200R1 gene

Publications
for CD200R1 gene

PubMed articles for CD200R1 gene, integrated from 9 sources (see all 43): (articles sorted by number of sources associating them with CD200R1)

Utopia: connect your pdf to the dynamic world of online information

1. Distribution of OX2 antigen and OX2 receptor within retina. (PubMed id 11133863)^{1, 3, 9} Dick A.D....Wright G.J. (2001)
2. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)^{1, 2, 9} Wright G.J....Barclay A.N. (2003)
3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
5. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. (PubMed id 10981966)^{1, 3} Wright G.J....Barclay A.N. (2000)
6. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. (PubMed id 15661892)^{1, 9} Cherwinski H.M....Phillips J.H. (2005)
7. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PubMed id 15274657)^{2, 9} Gorczynski R.M....Marsden P. (2004)
8. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PubMed id 19151626)^{1, 9} Koning N....Huitinga I. (2009)
9. Altered regulation of CD200 receptor in monocyte-deri ved macrophages from individuals with Parkinson's disease. (PubMed id 19924532)^{1, 9} Luo X.G....Ding J.Q. (2010)
10. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. (PubMed id 18164423)^{1, 9} Meuth S.G....Wiendl H. (2008)

External Searches for CD200R1 gene

Genome Databases showing CD200R1 gene

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Specialized Databases showing CD200R1 gene

Products
for CD200R1 gene