Aliases for CD200R1 Gene
External Ids for CD200R1 Gene
Previous HGNC Symbols for CD200R1 Gene
Previous GeneCards Identifiers for CD200R1 Gene
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD200R1 Gene
CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include primary hypertrophic osteoarthropathy. Among its related pathways are Signaling by GPCR and Immune System. An important paralog of this gene is CD200R1L.
UniProtKB/Swiss-Prot for CD200R1 Gene
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.