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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD200R1 Gene

protein-coding   GIFtS: 58
GCID: GC03M112640

CD200 Receptor 1

(Previous name: MOX2 receptor)
(Previous symbol: MOX2R)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD200 Receptor 11 2     CD200 Cell Surface Glycoprotein Receptor2 3
MOX2R1 2 3 5     HCRTR22
OX2R2 3 5     Cell Surface Glycoprotein CD200 Receptor 12
MOX2 Receptor1 2     Cell Surface Glycoprotein Receptor CD2002
Cell Surface Glycoprotein OX2 Receptor 12 3     CRTR23
CD200R2 3     

External Ids:    HGNC: 242351   Entrez Gene: 1314502   Ensembl: ENSG000001636067   OMIM: 6075465   UniProtKB: Q8TD463   

Export aliases for CD200R1 gene to outside databases

Previous GC identifers: GC03M114122 GC03M110025


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD200R1 Gene:
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface
glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid
lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse
studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD200R1 Gene: 
CD200R1 (CD200 receptor 1) is a protein-coding gene. Diseases associated with CD200R1 include smoldering myeloma, and cerebritis, and among its related super-pathways are Immune System and FCGR activation. GO annotations related to this gene include protein binding. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
Function: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with
identical affinity and kinetics as the host CD200

summary for CD200R1 Gene:
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex,
paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are
thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B.
The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

Gene Wiki entry for CD200R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD200R1 gene promoter:
         AhR   LHX3b/Lhx3b   ISGF-3   Sp1   FOXD3   Cdc5   Gfi-1   MEF-2A   AREB6   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD200R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD200R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD200R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13

CD200R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD200R1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112640:  view genomic region     (about GC identifiers)

Start:
112,640,056 bp from pter      End:
112,693,969 bp from pter
Size:
53,914 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46 (See protein sequence)
Recommended Name: Cell surface glycoprotein CD200 receptor 1 precursor  
Size: 325 amino acids; 36620 Da
Subunit: Interacts with Human herpesvirus 8 vOX2 protein
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
Secondary accessions: B3KWZ9 E9PCM9 Q52LJ7 Q6IS95 Q6UW94 Q6WHB8 Q8TD44 Q8TD45 Q8TD52
Alternative splicing: 4 isoforms:  Q8TD46-1   Q8TD46-2   Q8TD46-3   Q8TD46-4   

Explore the universe of human proteins at neXtProt for CD200R1: NX_Q8TD46

Explore proteomics data for CD200R1 at MOPED 

Post-translational modifications:

  • UniProtKB: The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD46

  • CD200R1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD200R1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_620161.1  NP_620385.1  NP_620386.1  NP_740750.1  

    ENSEMBL proteins: 
     ENSP00000418928   ENSP00000311035   ENSP00000295863   ENSP00000405733   ENSP00000418801  
    Reactome Protein details: Q8TD46
    Human Recombinant Protein Products for CD200R1: 
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    Novus Biologicals CD200R1 Proteins
    Novus Biologicals CD200R1 Lysates
    Sino Biological Recombinant Protein for CD200R1
    Sino Biological Cell Lysate for CD200R1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD200R1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    CD200R1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing

    4 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8TD46

    ProtoNet protein and cluster: Q8TD46

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
    Similarity: Belongs to the CD200R family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD200R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO2R1_HUMAN, Q8TD46
    Function: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with
    identical affinity and kinetics as the host CD200

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CD200R1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD200R1:
     Increased homologous recombina 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd200r1):
     immune system  mortality/aging  no phenotypic analysis 

    CD200R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD200R1: Cd200r1tm1.1Rmgo Cd200r1tm1Eakj

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD200R1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD200R1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD200R1 
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    SwitchGear 3'UTR luciferase reporter plasmidCD200R1 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CD200R1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD200R1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for CD200R1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System



    CD200R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD200R1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD200R1 (Q8TD461, 3 ENSP000003110354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD200P412171, 3, ENSP000004202984EBI-4314412,EBI-3910563 I2D: score=3 STRING: ENSP00000420298
    TYROBPO439143, ENSP000002626294I2D: score=1 STRING: ENSP00000262629
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0050776regulation of immune response TAS--

    CD200R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CD200R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Ala11,D-Leu15]-Orexin B Potent, selective OX2 receptor agonist [532932-99-3]
    EMPAHighly potent and selective OX2 antagonist; brain penetrant[680590-49-2]
    TCS OX2 29Potent and selective OX2 antagonist[372523-75-6]
    JNJ 10397049Selective OX2 receptor antagonist[708275-58-5]

    Search CenterWatch for drugs/clinical trials and news about CD200R1 / MO2R1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD200R1 gene (4 alternative transcripts): 
    NM_138806.3  NM_138939.2  NM_138940.2  NM_170780.2  

    Unigene Cluster for CD200R1:

    CD200 receptor 1
    Hs.309158  [show with all ESTs]
    Unigene Representative Sequence: AK126349
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471858(uc003dzk.1 uc011bhx.1) ENST00000308611(uc003dzj.1 uc003dzl.1 uc003dzm.1)
    ENST00000295863 ENST00000440122 ENST00000490004
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CD200R1 (see all 10):
    hsa-miR-98 hsa-let-7d hsa-miR-526b hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidCD200R1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200R1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD200R1
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    Additional mRNA sequence: 

    AF283760.1 AF495380.1 AF497548.1 AF497549.1 AF497550.1 AK126349.1 AK293071.1 AK304426.1 
    AY284975.1 AY358910.1 BC069661.1 BC069721.1 BC069743.1 BC093890.1 BC143393.1 

    4 DOTS entries:

    DT.91931497  DT.97763193  DT.100747887  DT.97837493 

    24/26 AceView cDNA sequences (see all 26):

    BC069721 NM_138940 NM_170780 AY284975 AF497550 BC069743 AF497549 AF497548 
    NM_138806 NM_138939 BC069661 AF495380 AF283760 AI867153 AK126349 AI393580 
    BQ946922 BQ045437 AY358910 AL700157 AL712200 BE041810 BX497703 BF170532 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -                                                   


    ECgene alternative splicing isoforms for CD200R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD200R1 expression in normal human tissues (normalized intensities)      CD200R1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD200R1 Expression
    About this image


    CD200R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             pre Conventional Dendritic Cells Peripheral Blood
             monocyte-derived dendritic cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             trachea   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Brain (Nervous System)
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...

    See CD200R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD200R1

    SOURCE GeneReport for Unigene cluster: Hs.309158

    UniProtKB/Swiss-Prot: MO2R1_HUMAN, Q8TD46
    Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK,
    NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord,
    kidney. Expressed in monocyte-derived dendritic and mast cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD200R1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd200r11 , 5 CD200 receptor 11, 5 70.85(n)1
    58.62(a)1
      16 (29.08 cM)5
    577811  NM_021325.31  NP_067300.11 
     447657365 
    chicken
    (Gallus gallus)
    Aves CD200R1L1 CD200 receptor 1-like 57.12(n)
    41.57(a)
      418367  NM_001030782.2  NP_001025953.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    25(a)
    1 → many
    3(175924347-175944837)
    zebrafish
    (Danio rerio)
    Actinopterygii CD200R1L6
    CD200 receptor 1-like
    17(a)
    1 → many
    9(9632421-9641116)


    ENSEMBL Gene Tree for CD200R1 (if available)
    TreeFam Gene Tree for CD200R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD200R1 gene
    CD200R1L2  
    1 SIMAP similar gene for CD200R1 using alignment to 3 protein entries:     MO2R1_HUMAN (see all proteins):
    CD200R1L

    CD200R1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD200R1
    PGOHUM00000237724


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1080 SNPs in CD200R1 are shown (see all 1080)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357166871,2
    F--110033758(-) ATTACTTAA/-  
            
    GTATA
    3 -- int15Minor allele frequency- -:0.49EU EA NA MN 430
    rs98790051,2
    C,F,A,H--112641046(+) CAAAAG/TAGCTG 2 -- ds500121Minor allele frequency- T:0.45NS EA NA WA CSA 2127
    rs1834200801,2
    --112641076(+) TATGAC/TTGAAG 2 -- ds50010--------
    rs98791491,2
    C,F,A,H--112641092(+) ATATAG/TTTTGT 2 -- ds500124Minor allele frequency- T:0.43NS EA NA WA CSA 2346
    rs1876942651,2
    C--112641138(+) TTTTTC/TTGCTA 2 -- ds50010--------
    rs752865411,2
    C,F--112641201(+) ATGATT/CTACAT 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs767224121,2
    C,F--112641202(+) TGATTT/CACATA 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs798341521,2
    C,F--112641212(+) AAACAT/CTGCCA 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs1905981691,2
    --112641327(+) GGTGCA/GTTTTT 2 -- ds50010--------
    rs1168017371,2
    F--112641333(+) TTTTTC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for CD200R1 (112640056 - 112693969 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD200R1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD200R1
    DNA2.0 Custom Variant and Variant Library Synthesis for CD200R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607546    OMIM disorders: --

    10 diseases for CD200R1:    About MalaCards
    smoldering myeloma    cerebritis    multiple sclerosis    parkinson's disease
    kaposi's sarcoma    myeloma    alzheimer's disease    sarcoma
    squamous cell carcinoma    neuronitis


    CD200R1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CD200R1

    Export disorders for CD200R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD200R1 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with CD200R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distribution of OX2 antigen and OX2 receptor within retina. (PubMed id 11133863)1, 3, 9 Dick A.D....Wright G.J. (2001)
    2. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)1, 2, 9 Wright G.J....Barclay A.N. (2003)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. (PubMed id 10981966)1, 3 Wright G.J....Barclay A.N. (2000)
    6. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. (PubMed id 15661892)1, 9 Cherwinski H.M....Phillips J.H. (2005)
    7. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PubMed id 15274657)2, 9 Gorczynski R.M....Marsden P. (2004)
    8. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PubMed id 19151626)1, 9 Koning N....Huitinga I. (2009)
    9. Altered regulation of CD200 receptor in monocyte-deri ved macrophages from individuals with Parkinson's disease. (PubMed id 19924532)1, 9 Luo X.G....Ding J.Q. (2010)
    10. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. (PubMed id 18164423)1, 9 Meuth S.G....Wiendl H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131450 HGNC: 24235 AceView: CD200R1 Ensembl:ENSG00000163606 euGenes: HUgn131450
    ECgene: CD200R1 H-InvDB: CD200R1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD200R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD200R1 gene:
    Search GeneIP for patents involving CD200R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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