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Aliases for CD200R1 Gene

Aliases for CD200R1 Gene

  • CD200 Receptor 1 2 3
  • MOX2R 3 4 6
  • OX2R 3 4 6
  • Cell Surface Glycoprotein OX2 Receptor 1 3 4
  • CD200 Cell Surface Glycoprotein Receptor 3 4
  • MOX2 Receptor 2 3
  • CD200R 3 4
  • Cell Surface Glycoprotein CD200 Receptor 1 3
  • Cell Surface Glycoprotein Receptor CD200 3
  • HCRTR2 3
  • CRTR2 4

External Ids for CD200R1 Gene

Previous Symbols for CD200R1 Gene

  • MOX2R

Summaries for CD200R1 Gene

Entrez Gene Summary for CD200R1 Gene

  • This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200R1 Gene

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot for CD200R1 Gene

  • Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Gene Wiki entry for CD200R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200R1 Gene

Genomics for CD200R1 Gene

Genomic Location for CD200R1 Gene

Start:
112,921,209 bp from pter
End:
112,975,122 bp from pter
Size:
53,914 bases
Orientation:
Minus strand

Genomic View for CD200R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD200R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200R1 Gene

Regulatory Elements for CD200R1 Gene

Proteins for CD200R1 Gene

  • Protein details for CD200R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD46-MO2R1_HUMAN
    Recommended name:
    Cell surface glycoprotein CD200 receptor 1
    Protein Accession:
    Q8TD46
    Secondary Accessions:
    • B3KWZ9
    • E9PCM9
    • Q52LJ7
    • Q6IS95
    • Q6UW94
    • Q6WHB8
    • Q8TD44
    • Q8TD45
    • Q8TD52

    Protein attributes for CD200R1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36620 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.

    Alternative splice isoforms for CD200R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200R1 Gene

Proteomics data for CD200R1 Gene at MOPED

Post-translational modifications for CD200R1 Gene

  • The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn37, Asn46, Asn93, Asn99, Asn162, Asn195, Asn210, and Asn224

Other Protein References for CD200R1 Gene

No data available for DME Specific Peptides for CD200R1 Gene

Domains for CD200R1 Gene

Gene Families for CD200R1 Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Protein Domains for CD200R1 Gene

UniProtKB/Swiss-Prot:

MO2R1_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q8TD46
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q8TD46
Family:
  • Belongs to the CD200R family.:
    • Q8TD46
genes like me logo Genes that share domains with CD200R1: view

Function for CD200R1 Gene

Molecular function for CD200R1 Gene

UniProtKB/Swiss-Prot Function: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Gene Ontology (GO) - Molecular Function for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD200R1: view

Phenotypes for CD200R1 Gene

genes like me logo Genes that share phenotypes with CD200R1: view

Animal Models for CD200R1 Gene

MGI Knock Outs for CD200R1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD200R1 Gene

Localization for CD200R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200R1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD200R1 Gene COMPARTMENTS Subcellular localization image for CD200R1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with CD200R1: view

Pathways for CD200R1 Gene

genes like me logo Genes that share pathways with CD200R1: view

Pathways by source for CD200R1 Gene

Interacting Proteins for CD200R1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311035%0d%0a9606.ENSP00000420298%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000311035 Q8TD46-MO2R1_HUMAN for CD200R1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD200R1: view

Transcripts for CD200R1 Gene

Unigene Clusters for CD200R1 Gene

CD200 receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD200R1 Gene

GeneLoc Exon Structure for
CD200R1
ECgene alternative splicing isoforms for
CD200R1

Expression for CD200R1 Gene

mRNA expression in normal human tissues for CD200R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200R1 Gene

This gene is overexpressed in Spleen (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD200R1 Gene

SOURCE GeneReport for Unigene cluster for CD200R1 Gene Hs.309158

mRNA Expression by UniProt/SwissProt for CD200R1 Gene

Q8TD46-MO2R1_HUMAN
Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
genes like me logo Genes that share expressions with CD200R1: view

Orthologs for CD200R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD200R1 36
  • 98.75 (n)
  • 97.7 (a)
CD200R1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 53 (a)
ManyToMany
CD200R1 37
  • 53 (a)
ManyToMany
CD200R1L 36
  • 75.54 (n)
  • 60.23 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 50 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
CD200R1 36
  • 72.54 (n)
  • 58.81 (a)
mouse
(Mus musculus)
Mammalia Cd200r1 36
  • 70.85 (n)
  • 58.62 (a)
Cd200r1 16
Cd200r1 37
  • 54 (a)
ManyToMany
Cd200r2 37
  • 54 (a)
ManyToMany
Cd200r3 37
  • 33 (a)
ManyToMany
Cd200r4 37
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd200r1 36
  • 71.25 (n)
  • 58.75 (a)
chicken
(Gallus gallus)
Aves CD200R1A 37
  • 30 (a)
ManyToMany
CD200R1L 36
  • 56.69 (n)
  • 41.24 (a)
CD200R1L 37
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731855 36
  • 51.19 (n)
  • 42.86 (a)
Species with no ortholog for CD200R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD200R1 Gene

ENSEMBL:
Gene Tree for CD200R1 (if available)
TreeFam:
Gene Tree for CD200R1 (if available)

Paralogs for CD200R1 Gene

Paralogs for CD200R1 Gene

Selected SIMAP similar genes for CD200R1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD200R1 Gene

genes like me logo Genes that share paralogs with CD200R1: view

Variants for CD200R1 Gene

Sequence variations from dbSNP and Humsavar for CD200R1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1016348 -- 112,929,759(+) TTATA(C/T)TAATG intron-variant
rs1032726 -- 112,967,228(-) GGGTT(A/G)AGGAG intron-variant
rs1154267 -- 112,970,057(+) cctgt(A/G)gtccc intron-variant
rs1154268 -- 112,958,962(-) AAGTA(C/T)GGGTC intron-variant
rs1154269 -- 112,955,859(-) gactt(C/T)tcagc intron-variant

Relevant External Links for CD200R1 Gene

HapMap Linkage Disequilibrium report
CD200R1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CD200R1 Gene

Disorders for CD200R1 Gene

Relevant External Links for CD200R1

Genetic Association Database (GAD)
CD200R1
genes like me logo Genes that share disorders with CD200R1: view

No data available for UniProtKB/Swiss-Prot for CD200R1 Gene

Publications for CD200R1 Gene

  1. Distribution of OX2 antigen and OX2 receptor within retina. (PMID: 11133863) Dick A.D. … Wright G.J. (Invest. Ophthalmol. Vis. Sci. 2001) 2 3 23
  2. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PMID: 12960329) Wright G.J. … Barclay A.N. (J. Immunol. 2003) 3 4 23
  3. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. (PMID: 18164423) Meuth S.G. … Wiendl H. (J. Neuroimmunol. 2008) 3 23
  4. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PMID: 19151626) Koning N. … Huitinga I. (J. Neuropathol. Exp. Neurol. 2009) 3 23
  5. Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface. (PMID: 15274657) Gorczynski R.M. … Marsden P. (Am. J. Reprod. Immunol. 2004) 4 23

Products for CD200R1 Gene

Sources for CD200R1 Gene

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