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Aliases for CD200R1 Gene

Aliases for CD200R1 Gene

  • CD200 Receptor 1 2 3 5
  • Cell Surface Glycoprotein OX2 Receptor 1 3 4
  • CD200 Cell Surface Glycoprotein Receptor 3 4
  • MOX2 Receptor 2 3
  • CD200R 3 4
  • MOX2R 3 4
  • OX2R 3 4
  • Cell Surface Glycoprotein Receptor CD200 3
  • HCRTR2 3
  • CRTR2 4

External Ids for CD200R1 Gene

Previous HGNC Symbols for CD200R1 Gene

  • MOX2R

Previous GeneCards Identifiers for CD200R1 Gene

  • GC03M114122
  • GC03M112640
  • GC03M110025

Summaries for CD200R1 Gene

Entrez Gene Summary for CD200R1 Gene

  • This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200R1 Gene

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include primary hypertrophic osteoarthropathy. Among its related pathways are Signaling by GPCR and Immune System. An important paralog of this gene is CD200R1L.

UniProtKB/Swiss-Prot for CD200R1 Gene

  • Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Gene Wiki entry for CD200R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200R1 Gene

Genomics for CD200R1 Gene

Regulatory Elements for CD200R1 Gene

Promoters for CD200R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD200R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD200R1 Gene

Chromosome:
3
Start:
112,921,057 bp from pter
End:
112,975,122 bp from pter
Size:
54,066 bases
Orientation:
Minus strand

Genomic View for CD200R1 Gene

Genes around CD200R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200R1 Gene

Proteins for CD200R1 Gene

  • Protein details for CD200R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD46-MO2R1_HUMAN
    Recommended name:
    Cell surface glycoprotein CD200 receptor 1
    Protein Accession:
    Q8TD46
    Secondary Accessions:
    • B3KWZ9
    • E9PCM9
    • Q52LJ7
    • Q6IS95
    • Q6UW94
    • Q6WHB8
    • Q8TD44
    • Q8TD45
    • Q8TD52

    Protein attributes for CD200R1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36620 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.

    Alternative splice isoforms for CD200R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200R1 Gene

Proteomics data for CD200R1 Gene at MOPED

Post-translational modifications for CD200R1 Gene

  • The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
  • Glycosylation at Asn 37, Asn 46, Asn 93, Asn 99, Asn 162, Asn 195, Asn 210, and Asn 224
  • Modification sites at PhosphoSitePlus

Other Protein References for CD200R1 Gene

Antibody Products

No data available for DME Specific Peptides for CD200R1 Gene

Domains & Families for CD200R1 Gene

Gene Families for CD200R1 Gene

Protein Domains for CD200R1 Gene

Suggested Antigen Peptide Sequences for CD200R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD46

UniProtKB/Swiss-Prot:

MO2R1_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the CD200R family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD200R family.
genes like me logo Genes that share domains with CD200R1: view

Function for CD200R1 Gene

Molecular function for CD200R1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
genes like me logo Genes that share phenotypes with CD200R1: view

Animal Models for CD200R1 Gene

MGI Knock Outs for CD200R1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD200R1

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD200R1 Gene

Localization for CD200R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200R1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD200R1 Gene COMPARTMENTS Subcellular localization image for CD200R1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD200R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with CD200R1: view

Pathways & Interactions for CD200R1 Gene

genes like me logo Genes that share pathways with CD200R1: view

Pathways by source for CD200R1 Gene

Interacting Proteins for CD200R1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311035%0d%0a9606.ENSP00000420298%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: Q8TD46-MO2R1_HUMAN ENSP00000311035 for CD200R1 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for CD200R1 Gene

None

No data available for SIGNOR curated interactions for CD200R1 Gene

Drugs & Compounds for CD200R1 Gene

No Compound Related Data Available

Transcripts for CD200R1 Gene

Unigene Clusters for CD200R1 Gene

CD200 receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD200R1 Gene

GeneLoc Exon Structure for
CD200R1
ECgene alternative splicing isoforms for
CD200R1

Expression for CD200R1 Gene

mRNA expression in normal human tissues for CD200R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200R1 Gene

This gene is overexpressed in Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for CD200R1 Gene

This gene is overexpressed in Liver, secretome (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD200R1 Gene



SOURCE GeneReport for Unigene cluster for CD200R1 Gene Hs.309158

mRNA Expression by UniProt/SwissProt for CD200R1 Gene

Q8TD46-MO2R1_HUMAN
Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
genes like me logo Genes that share expression patterns with CD200R1: view

Protein tissue co-expression partners for CD200R1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD200R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD200R1L 35
  • 75.54 (n)
  • 60.23 (a)
-- 36
  • 53 (a)
ManyToMany
CD200R1 36
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD200R1 35
  • 72.54 (n)
  • 58.81 (a)
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd200r1 35
  • 70.85 (n)
  • 58.62 (a)
Cd200r1 16
Cd200r1 36
  • 54 (a)
ManyToMany
Cd200r2 36
  • 54 (a)
ManyToMany
Cd200r3 36
  • 33 (a)
ManyToMany
Cd200r4 36
  • 50 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CD200R1 35
  • 98.75 (n)
  • 97.7 (a)
CD200R1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd200r1 35
  • 71.25 (n)
  • 58.75 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CD200R1L 35
  • 56.69 (n)
  • 41.24 (a)
CD200R1A 36
  • 30 (a)
ManyToMany
CD200R1L 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731855 35
  • 51.19 (n)
  • 42.86 (a)
Species with no ortholog for CD200R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD200R1 Gene

ENSEMBL:
Gene Tree for CD200R1 (if available)
TreeFam:
Gene Tree for CD200R1 (if available)

Paralogs for CD200R1 Gene

Paralogs for CD200R1 Gene

(1) SIMAP similar genes for CD200R1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD200R1 Gene

genes like me logo Genes that share paralogs with CD200R1: view

Variants for CD200R1 Gene

Sequence variations from dbSNP and Humsavar for CD200R1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2171509 - 112,929,375(-) CTACA(A/G)GAAAG reference, missense
rs4596117 - 112,929,280(+) CACGG(G/T)ACGAA reference, missense
rs9826308 - 112,928,985(+) GAGAT(A/C)TGCGC reference, missense, utr-variant-3-prime
rs9865242 - 112,923,721(+) TGCCT(C/G)AGATG reference, missense, utr-variant-3-prime
rs1032726 -- 112,967,228(-) GGGTT(A/G)AGGAG intron-variant

Variation tolerance for CD200R1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD200R1 Gene

HapMap Linkage Disequilibrium report
CD200R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD200R1 Gene

Disorders for CD200R1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD200R1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CD200R1

Genetic Association Database (GAD)
CD200R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD200R1
genes like me logo Genes that share disorders with CD200R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200R1 Gene

Publications for CD200R1 Gene

  1. Distribution of OX2 antigen and OX2 receptor within retina. (PMID: 11133863) Dick A.D. … Wright G.J. (Invest. Ophthalmol. Vis. Sci. 2001) 2 3 23 67
  2. Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease. (PMID: 19924532) Luo X.G. … Ding J.Q. (Neurochem. Res. 2010) 3 23
  3. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. (PMID: 19151626) Koning N. … Huitinga I. (J. Neuropathol. Exp. Neurol. 2009) 3 23
  4. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. (PMID: 18164423) Meuth S.G. … Wiendl H. (J. Neuroimmunol. 2008) 3 23
  5. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. (PMID: 15661892) Cherwinski H.M. … Phillips J.H. (J. Immunol. 2005) 3 23

Products for CD200R1 Gene

Sources for CD200R1 Gene

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