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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD200 Gene

protein-coding   GIFtS: 57
GCID: GC03P112051

CD200 Molecule

(Previous names: antigen identified by monoclonal antibody MRC OX-2, CD2...)
(Previous symbols: MOX1, MOX2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD200 Molecule1 2     MRC2
MOX21 2 3 5     OX-22
MOX11 2 3     MRC OX-2 Antigen2
CD200 Antigen1 2 3     OX-2 Membrane Glycoprotein2
Antigen Identified By Monoclonal Antibody MRC OX-21 2     

External Ids:    HGNC: 72031   Entrez Gene: 43452   Ensembl: ENSG000000919727   OMIM: 1559705   UniProtKB: P412173   

Export aliases for CD200 gene to outside databases

Previous GC identifers: GC03M109425 GC03P113534 GC03P109436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD200 Gene:
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and
thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this
gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse
tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD200 Gene: 
CD200 (CD200 molecule) is a protein-coding gene. Diseases associated with CD200 include angioimmunoblastic t-cell lymphoma, and androgenetic alopecia, and among its related super-pathways are Immune System and FCGR activation. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: OX2G_HUMAN, P41217
Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

Gene Wiki entry for CD200 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD200 gene promoter:
         COUP-TF1   COUP-TF   p53   COUP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD200 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD200

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD200


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

CD200 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD200 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P112051:  view genomic region     (about GC identifiers)

Start:
112,051,194 bp from pter      End:
112,081,659 bp from pter
Size:
30,466 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OX2G_HUMAN, P41217 (See protein sequence)
Recommended Name: OX-2 membrane glycoprotein precursor  
Size: 278 amino acids; 31264 Da
Subunit: Interacts with CD200R1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: B3KQI1 B4DLW9 D3DN65 Q6J2Q6 Q6PIQ4 Q8TB85 Q9H3J3
Alternative splicing: 3 isoforms:  P41217-1   P41217-2   P41217-3   

Explore the universe of human proteins at neXtProt for CD200: NX_P41217

Explore proteomics data for CD200 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41217

  • CD200 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD200 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001004196.2  NP_005935.4  

    ENSEMBL proteins: 
     ENSP00000476114   ENSP00000475860   ENSP00000418576   ENSP00000420298   ENSP00000312766  
     ENSP00000373179   ENSP00000419816  
    Reactome Protein details: P41217
    Human Recombinant Protein Products for CD200: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD200
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD200
    OriGene Protein Over-expression Lysate for CD200
    OriGene MassSpec for CD200 
    OriGene Custom Protein Services for CD200
    GenScript Custom Purified and Recombinant Proteins Services for CD200
    Novus Biologicals CD200 Proteins
    Novus Biologicals CD200 Lysates
    Sino Biological Recombinant Protein for CD200
    Sino Biological Cell Lysate for CD200 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD200 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS3032785

    CD200 for ontologies           About GeneDecksing



    CD200 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CD200 

    Assay Products for CD200: 
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    Cloud-Clone Corp. ELISAs for CD200 
    Cloud-Clone Corp. CLIAs for CD200


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P41217

    ProtoNet protein and cluster: P41217

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: OX2G_HUMAN, P41217
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD200 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OX2G_HUMAN, P41217
    Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CD200 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd200):
     adipose tissue  behavior/neurological  cellular  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  nervous system  other  skeleton 

    CD200 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd200tm1Jods for CD200

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD200 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD200

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD200 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD200 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD200 (see all 26):
    hsa-let-7d hsa-miR-202 hsa-miR-411 hsa-let-7c hsa-miR-410 hsa-miR-1297 hsa-miR-548m hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCD200 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD200
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD200

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD200

    Clone
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    OriGene ORF clones in mouse, rat for CD200
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD200 (NM_005944)
    Sino Biological Human cDNA Clone for CD200
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200
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                         Customized lentivirus expression plasmids for stable overexpression of CD200 

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    Search LifeMap BioReagents cell lines for CD200
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD200 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for CD200
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System



    CD200 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD200

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CD200 (P412171, 3 ENSP000004202984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD200R1Q8TD461, 3, ENSP000003110354EBI-3910563,EBI-4314412 I2D: score=3 STRING: ENSP00000311035
    HCRTR2O436143, ENSP000003598994I2D: score=2 STRING: ENSP00000359899
    SLC2A4P146723I2D: score=1 
    HUS1ENSP000002587744STRING: ENSP00000258774
    CD200R1LENSP000003812724STRING: ENSP00000381272
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050776regulation of immune response TAS--

    CD200 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD200 (OX2G)

    Search CenterWatch for drugs/clinical trials and news about CD200 / OX2G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD200 gene (3 alternative transcripts): 
    NM_001004196.2  NM_005944.5  NM_001004197.1  

    Unigene Cluster for CD200:

    CD200 molecule
    Hs.79015  [show with all ESTs]
    Unigene Representative Sequence: NM_001004196
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607597 ENST00000606471 ENST00000607516 ENST00000498096(uc010hqd.1)
    ENST00000473539 ENST00000315711(uc003dyw.3 uc003dyx.3 uc003dyz.3 uc003dyy.3)
    ENST00000383681 ENST00000478595
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD200
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD200 (see all 26):
    hsa-let-7d hsa-miR-202 hsa-miR-411 hsa-let-7c hsa-miR-410 hsa-miR-1297 hsa-miR-548m hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCD200 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD200
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD200
    Clone
    Products:
         
    OriGene clones in human, mouse for CD200 (see all 14)
    OriGene ORF clones in mouse, rat for CD200
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD200 (NM_005944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200
    Sirion Biotech Customized lentivirus for stable overexpression of CD200 
                         Customized lentivirus expression plasmids for stable overexpression of CD200 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD200
    OriGene qSTAR qPCR primer pairs in human, mouse for CD200
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD200
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD200
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD200

    Additional mRNA sequence: 

    AF063591.1 AK074972.1 AK129797.1 AK293399.1 AK297194.1 AK312563.1 AL832529.1 AY603771.1 
    BC022522.1 BC031103.1 

    16 DOTS entries:

    DT.448621  DT.101982240  DT.92430640  DT.100787121  DT.97842271  DT.100787116  DT.92430636  DT.120853032 
    DT.120853041  DT.95256488  DT.120853044  DT.120853056  DT.120853057  DT.120853069  DT.92430637  DT.97842270 

    24/219 AceView cDNA sequences (see all 219):

    AI985188 AK129797 CR596077 BU076106 F03740 F07509 BX396301 F06357 
    W72072 BQ897191 NM_001004197 BX380230 NM_001004196 CR593426 BG819090 NM_005944 
    CR621717 CR590097 AI185586 BX358067 BP373175 CR620294 CR611430 BE463950 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CD200 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^
    SP1:                                      -     -     -     -     -     -                       -     -     -     -                                             
    SP2:                                      -     -     -     -                                   -     -     -     -                                             
    SP3:                                      -     -     -     -     -     -     -                 -     -     -     -                                             
    SP4:                                      -     -     -     -     -     -     -                 -     -     -     -                                             
    SP5:                                      -     -     -     -     -     -                       -     -     -     -                                             

    ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
    SP1:  -           -                           
    SP2:                                          
    SP3:  -           -                           
    SP4:  -           -                           
    SP5:                                          


    ECgene alternative splicing isoforms for CD200

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD200 expression in normal human tissues (normalized intensities)      CD200 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTATTTAA
    CD200 Expression
    About this image


    CD200 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Bone Marrow Stromal Cells Bone Marrow
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Bone Marrow Stromal Cells Bone Marrow
             skeleton/cranium/viscerocranium   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Wharton's jelly-derived stem cells
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See CD200 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD200

    SOURCE GeneReport for Unigene cluster: Hs.79015
        SABiosciences Custom PCR Arrays for CD200
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD200 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd2001 , 5 CD200 antigen1, 5 81.75(n)1
    77.57(a)1
      16 (29.53 cM)5
    174701  NM_010818.31  NP_034948.31 
     453821355 
    chicken
    (Gallus gallus)
    Aves CD2001 CD200 molecule 51.05(n)
    36.82(a)
      418425  NM_001030787.1  NP_001025958.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD2006
    CD200 molecule
    30(a)
    1 ↔ 1
    3(167551522-167568313)
    zebrafish
    (Danio rerio)
    Actinopterygii CD200 (1 of 3)6
    CD200 (2 of 3)6
    (see all 3)
    CD200 molecule
    (see all 3)
    16(a)
    15(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    9(9541548-9569470)
    1(34817260-34840332)


    ENSEMBL Gene Tree for CD200 (if available)
    TreeFam Gene Tree for CD200 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/773 SNPs in CD200 are shown (see all 773)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108045001,2
    C,F,A,H--112050057(+) TTCCAA/GTTTGA 2 -- us2k111Minor allele frequency- G:0.44EA NS NA WA 1008
    rs119234021,2
    C,F,H--112050148(+) TCAGTG/TAGAAT 2 -- us2k15Minor allele frequency- T:0.28NA WA 248
    rs592511071,2
    C--112050157(+) ATGAAA/TAAGCC 2 -- us2k10--------
    rs1921955541,2
    --112050178(+) CAATAA/GCATGG 2 -- us2k10--------
    rs1378692641,2
    --112050209(+) GTTGAA/GTAAAA 2 -- us2k10--------
    rs1829906101,2
    --112050239(+) ACATAG/TGCTAC 2 -- us2k10--------
    rs1886913241,2
    --112050279(+) GTGAGC/TCTAGT 2 -- us2k10--------
    rs98536691,2
    C,F,A,H--112050544(+) gagccA/Gagatc 2 -- us2k12Minor allele frequency- G:0.33NA 6
    rs786075831,2
    C--112050606(+) CCACCC/GCCCCC 2 -- us2k10--------
    rs360073491,2
    C--112050607(+) CCCCC-/CAAAAA 2 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CD200 (112051194 - 112081659 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD200:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv10307CNV Gain18304495
    nsv877341CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 155970    OMIM disorders: --

    20/21 diseases for CD200 (see all 21):    About MalaCards
    angioimmunoblastic t-cell lymphoma    androgenetic alopecia    spotted fever    alopecia
    mantle cell lymphoma    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    multiple myeloma
    pre-eclampsia    eclampsia    myeloma    multiple sclerosis
    b-cell lymphomas    parkinson's disease    acute myeloid leukemia    retinitis
    alzheimer's disease    myeloid leukemia    melanoma    leukemia


    CD200 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for CD200 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    miscarriage 41 1 15274657 (1)

    Genetic Association Database (GAD): CD200
    Human Genome Epidemiology (HuGE) Navigator: CD200 (1 document)

    Export disorders for CD200 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD200 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with CD200)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein. (PubMed id 3032785)1, 2 McCaughan G.W.... Barclay A.N. (1987)
    5. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. (PubMed id 15699757)1, 9 Chen D.X. and Gorczynski R.M. (2005)
    6. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. (PubMed id 16177086)1, 9 Shiratori I....Arase H. (2005)
    7. CD200: a putative therapeutic target in cancer. (PubMed id 18060862)1, 9 Moreaux J....Klein B. (2008)
    8. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. (PubMed id 11260322)1, 9 Wright G.J....Barclay A.N. (2001)
    9. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)1, 9 Wright G.J....Barclay A.N. (2003)
    10. CD200 upregulation in vascular endothelium surrounding cutaneous squamous cell carcinoma. (PubMed id 23560298)1 Belkin D.A....Carucci J.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4345 HGNC: 7203 AceView: CD200 Ensembl:ENSG00000091972 euGenes: HUgn4345
    ECgene: CD200 H-InvDB: CD200

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD200 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD200 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD200 gene:
    Search GeneIP for patents involving CD200

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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