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Aliases for CD200 Gene

Aliases for CD200 Gene

  • CD200 Molecule 2 3
  • CD200 Antigen 2 3 4
  • Antigen Identified By Monoclonal Antibody MRC OX-2 2 3
  • MOX1 3 4
  • MOX2 3 4
  • MRC OX-2 Antigen 3
  • OX-2 3
  • MRC 3

External Ids for CD200 Gene

Previous HGNC Symbols for CD200 Gene

  • MOX1
  • MOX2

Previous GeneCards Identifiers for CD200 Gene

  • GC03M109425
  • GC03P113534
  • GC03P112051
  • GC03P109436

Summaries for CD200 Gene

Entrez Gene Summary for CD200 Gene

  • The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200 Gene

CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include klippel-feil syndrome 2 and primary hypertrophic osteoarthropathy. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

UniProtKB/Swiss-Prot for CD200 Gene

  • Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

Gene Wiki entry for CD200 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200 Gene

Genomics for CD200 Gene

Regulatory Elements for CD200 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD200 Gene

Chromosome:
3
Start:
112,332,347 bp from pter
End:
112,362,812 bp from pter
Size:
30,466 bases
Orientation:
Plus strand

Genomic View for CD200 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200 Gene

Proteins for CD200 Gene

  • Protein details for CD200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41217-OX2G_HUMAN
    Recommended name:
    OX-2 membrane glycoprotein
    Protein Accession:
    P41217
    Secondary Accessions:
    • B3KQI1
    • B4DLW9
    • D3DN65
    • Q6J2Q6
    • Q6PIQ4
    • Q8TB85
    • Q9H3J3

    Protein attributes for CD200 Gene

    Size:
    278 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains

    Alternative splice isoforms for CD200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200 Gene

Proteomics data for CD200 Gene at MOPED

Post-translational modifications for CD200 Gene

  • Glycosylation at Asn 95, Asn 103, Asn 110, Asn 157, Asn 181, and Asn 190
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD200 Gene

Domains & Families for CD200 Gene

Gene Families for CD200 Gene

Protein Domains for CD200 Gene

Suggested Antigen Peptide Sequences for CD200 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41217

UniProtKB/Swiss-Prot:

OX2G_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD200: view

Function for CD200 Gene

Molecular function for CD200 Gene

UniProtKB/Swiss-Prot Function:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

Gene Ontology (GO) - Molecular Function for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 21982860
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with CD200: view
genes like me logo Genes that share phenotypes with CD200: view

Animal Models for CD200 Gene

MGI Knock Outs for CD200:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD200

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD200 Gene

Localization for CD200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD200 Gene COMPARTMENTS Subcellular localization image for CD200 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3032785
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with CD200: view

Pathways & Interactions for CD200 Gene

genes like me logo Genes that share pathways with CD200: view

Pathways by source for CD200 Gene

Gene Ontology (GO) - Biological Process for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD200: view

No data available for SIGNOR curated interactions for CD200 Gene

Drugs & Compounds for CD200 Gene

No Compound Related Data Available

Transcripts for CD200 Gene

Unigene Clusters for CD200 Gene

CD200 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD200

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14:
SP15: - - -
SP16: - - - - - - -
SP17:

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - -
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CD200 Gene

GeneLoc Exon Structure for
CD200
ECgene alternative splicing isoforms for
CD200

Expression for CD200 Gene

mRNA expression in normal human tissues for CD200 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for CD200 Gene

This gene is overexpressed in Placenta (31.5), Frontal cortex (12.6), and Fetal Brain (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD200 Gene



SOURCE GeneReport for Unigene cluster for CD200 Gene Hs.79015

genes like me logo Genes that share expression patterns with CD200: view

Protein tissue co-expression partners for CD200 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD200 Gene

Orthologs for CD200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD200 35
  • 84.79 (n)
  • 80.23 (a)
CD200 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD200 35
  • 82.83 (n)
  • 77.27 (a)
CD200 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd200 35
  • 81.75 (n)
  • 77.57 (a)
Cd200 16
Cd200 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD200 35
  • 99.62 (n)
  • 99.62 (a)
CD200 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd200 35
  • 80.61 (n)
  • 76.81 (a)
oppossum
(Monodelphis domestica)
Mammalia CD200 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD200 35
  • 53.68 (n)
  • 40 (a)
CD200 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD200 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CD200 (1 of 3) 36
  • 17 (a)
OneToMany
CD200 (2 of 3) 36
  • 15 (a)
OneToMany
CD200 (3 of 3) 36
  • 15 (a)
OneToMany
Species with no ortholog for CD200:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD200 Gene

ENSEMBL:
Gene Tree for CD200 (if available)
TreeFam:
Gene Tree for CD200 (if available)

Paralogs for CD200 Gene

No data available for Paralogs for CD200 Gene

Variants for CD200 Gene

Sequence variations from dbSNP and Humsavar for CD200 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_027605 -
VAR_027606 -
VAR_056110 -

Structural Variations from Database of Genomic Variants (DGV) for CD200 Gene

Variant ID Type Subtype PubMed ID
nsv10307 CNV Gain 18304495
nsv877341 CNV Gain 21882294

Variation tolerance for CD200 Gene

Residual Variation Intolerance Score: 55.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD200 Gene

HapMap Linkage Disequilibrium report
CD200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200 Gene

Disorders for CD200 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD200 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
klippel-feil syndrome 2
  • klippel-feil syndrome 2, autosomal recessive
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
mantle cell lymphoma
  • lymphocytic choriomeningitis
- elite association
Search CD200 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD200

Genetic Association Database (GAD)
CD200
Human Genome Epidemiology (HuGE) Navigator
CD200
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD200
genes like me logo Genes that share disorders with CD200: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200 Gene

Publications for CD200 Gene

  1. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. (PMID: 19542319) Malherbe P. … Knoflach F. (Mol. Pharmacol. 2009) 23 67
  2. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. (PMID: 19786546) Mihrshahi R. … Brown M.H. (J. Immunol. 2009) 23 67
  3. Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation. (PMID: 18938162) Walker D.G. … Lue L.F. (Exp. Neurol. 2009) 23 67
  4. Control of viral immunoinflammatory lesions by manipulating CD200:CD200 receptor interaction. (PMID: 19070547) Sarangi P.P. … Rouse B.T. (Clin. Immunol. 2009) 23 67
  5. CD200: a putative therapeutic target in cancer. (PMID: 18060862) Moreaux J. … Klein B. (Biochem. Biophys. Res. Commun. 2008) 23 67

Products for CD200 Gene

Sources for CD200 Gene

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