CD200 Gene

Aliases
for CD200 gene

Previous GC identifers: GC03M109425 GC03P113534 GC03P109436

Summaries
for CD200 gene

Genomic Views
for CD200 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: CD200 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD200

CD200 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P112051:  view genomic region     (about GC identifiers)

Proteins
for CD200 gene

Explore the universe of human proteins at neXtProt for CD200: NX_P41217

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD200
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD200 OriGene Protein Over-expression Lysate (see all 3): CD200 OriGene Custom Protein Services for CD200
	GenScript Custom Purified and Recombinant Proteins Services for CD200
	Novus Biologicals CD200 Proteins Novus Biologicals CD200 Lysates
	Sino Biological Recombinant Protein for CD200
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD200

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD200
	Browse OriGene Antibodies OriGene Custom Antibody Services for CD200
	GenScript Custom Superior Antibodies Services for CD200
	Novus Biologicals CD200 Antibodies
	Search for Antibodies for CD200 at Abcam
	Uscn Antibodies for CD200
	ThermoFisher Antibodies for CD200

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CD200
	GenScript Custom Assay Services for CD200
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD200

Protein Domains /
Families
for CD200 gene

ProtoNet protein and cluster: P41217

Function
for CD200 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD200 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD200
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD200 (see all 26):
		hsa-let-7d hsa-miR-202 hsa-miR-411 hsa-let-7c hsa-miR-410 hsa-miR-1297 hsa-miR-548m hsa-let-7g
		SwitchGear 3'UTR luciferase reporter plasmid: CD200 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD200 (see all 7) OriGene shRNA RFP: CD200 OriGene siRNA: CD200
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD200

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD200

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD200 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD200 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD200 (NM_005944)
		Sino Biological Human cDNA Clone for CD200
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD200
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD200

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD200
		Search LifeMap BioReagents cell lines for CD200

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cd200)

Pathways & Interactions
for CD200 gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Cleavage of Alpha-1-Microglobulin	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.30

3        Reactome Pathways for CD200

	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Immune System

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for CD200 gene

Transcripts
for CD200 gene

Expression
for CD200 gene

CD200 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTATTTAA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Umbilical CordWharton's JellyUmbilical Cord Mesenchymal Stem Cells			Extraembryonic Tissues, Umbilical Cord
	BoneStylopod Long Bone			Bone
	BoneThoracic Rib			Bone
	BoneZeugopod Long Bone			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD200 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD200
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD200
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD200

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD200

Orthologs
for CD200 gene

Paralogs
for CD200 gene

Genomic Variants
for CD200 gene

10/659 NCBI SNPs in CD200 are shown (see all 659)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs108045001,2	C,F,A,H,	--	112050057(+)	TTCCAA/GTTTGA	2	--	us2k1		11		EA NS NA WA	1008
rs119234021,2	C,F,H,	--	112050148(+)	TCAGTG/TAGAAT	2	--	us2k1		5		NA WA	248
rs592511071,2		--	112050157(+)	ATGAAA/TAAGCC	2	--	us2k1		0	--	--	--	--
rs1921955541,2		--	112050178(+)	CAATAA/GCATGG	2	--	us2k1		0	--	--	--	--
rs1378692641,2		--	112050209(+)	GTTGAA/GTAAAA	2	--	us2k1		0	--	--	--	--
rs1829906101,2		--	112050239(+)	ACATAG/TGCTAC	2	--	us2k1		0	--	--	--	--
rs1886913241,2		--	112050279(+)	GTGAGC/TCTAGT	2	--	us2k1		0	--	--	--	--
rs98536691,2	C,F,A,H,	--	112050544(+)	gagccA/Gagatc	2	--	us2k1		2		NA	6
rs786075831,2	C	--	112050606(+)	CCACCC/GCCCCC	2	--	us2k1		0	--	--	--	--
rs360073491,2	C,	--	112050607(+)	CCCCC-/CAAAAA	2	--	us2k1		1		NA	2

HapMap Linkage Disequilibrium report for CD200 (112051915 - 112081659 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CD200: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD200

DNA2.0 Custom Variant and Variant Library Synthesis for CD200

Disorders / Diseases
for CD200 gene

17 diseases for CD200

1 Novoseek disease relationship for CD200 gene    About this table

Publications
for CD200 gene

PubMed articles for CD200 gene, integrated from 9 sources (see all 66): (articles sorted by number of sources associating them with CD200)

Utopia: connect your pdf to the dynamic world of online information

1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein. (PubMed id 3032785)^{1, 2} McCaughan G.W.... Barclay A.N. (1987)
4. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. (PubMed id 15699757)^{1, 9} Chen D.X. and Gorczynski R.M. (2005)
5. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. (PubMed id 16177086)^{1, 9} Shiratori I....Arase H. (2005)
6. CD200: a putative therapeutic target in cancer. (PubMed id 18060862)^{1, 9} Moreaux J....Klein B. (2008)
7. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. (PubMed id 11260322)^{1, 9} Wright G.J....Barclay A.N. (2001)
8. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PubMed id 12960329)^{1, 9} Wright G.J....Barclay A.N. (2003)
9. Melanoma cell expression of CD200 inhibits tumor forma tion and lung metastasis via inhibition of myeloid cell functions. (PubMed id 22319630)¹ Talebian F....Bai X.F. (2012)
10. Soluble CD200 is critical to engraft chronic lymphocyt ic leukemia cells in immunocompromised mice. (PubMed id 22875025)¹ Wong K.K....Gorczynski R.M. (2012)

External Searches for CD200 gene

Genome Databases showing CD200 gene

Other Databases showing CD200 gene

Specialized Databases showing CD200 gene

Products
for CD200 gene