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Aliases for CD200 Gene

Aliases for CD200 Gene

  • CD200 Molecule 2 3 5
  • CD200 Antigen 2 3 4
  • Antigen Identified By Monoclonal Antibody MRC OX-2 2 3
  • MOX1 3 4
  • MOX2 3 4
  • OX-2 Membrane Glycoprotein 3
  • OX-2 3
  • MRC 3

External Ids for CD200 Gene

Previous HGNC Symbols for CD200 Gene

  • MOX1
  • MOX2

Previous GeneCards Identifiers for CD200 Gene

  • GC03M109425
  • GC03P113534
  • GC03P112051
  • GC03P109436

Summaries for CD200 Gene

Entrez Gene Summary for CD200 Gene

  • This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CD200 Gene

CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include Hairy Cell Leukemia and Mantle Cell Lymphoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System.

UniProtKB/Swiss-Prot for CD200 Gene

  • Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Gene Wiki entry for CD200 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200 Gene

Genomics for CD200 Gene

Regulatory Elements for CD200 Gene

Enhancers for CD200 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F112375 1.5 FANTOM5 Ensembl ENCODE 19.1 +45.8 45754 4.6 ATF1 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF2 RFX5 ZNF366 FOS CD200 ENSG00000261488 SLC9C1 ATG3 GC03M112363 LOC105374041
GH03F112357 1.4 FANTOM5 Ensembl ENCODE 17.3 +29.3 29259 9.2 ZFP64 JUN BMI1 RELA GATA3 POLR2A SCRT2 FOS PRDM10 SCRT1 CD200 BTLA MIR567 C3orf52 ENSG00000239482 SLC9C1 ENSG00000261488 ATG3
GH03F112393 1 Ensembl ENCODE 18.1 +63.6 63562 4.5 HDGF PKNOX1 JUN ASH2L POLR2A EED ZNF207 ETV6 MAFK CREM CD200 BTLA MIR567 C3orf52 LOC105374041 GC03M112363
GH03F112389 1.3 FANTOM5 Ensembl ENCODE 12.9 +58.7 58712 3.4 SOX13 SRF SIX4 PKNOX1 JUN BHLHE40 REST ZBTB40 OSR2 SREBF1 CD200 BTLA MIR567 C3orf52 LOC105374041 GC03M112363
GH03F112494 1.4 FANTOM5 Ensembl ENCODE 10.7 +165.6 165601 6.7 HDGF TBP PKNOX1 MXI1 ZNF146 WRNIP1 JUN ASH2L RELA YY1 SLC35A5 BTLA CD200 MIR567 C3orf52 LOC105374041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD200 on UCSC Golden Path with GeneCards custom track

Promoters for CD200 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001370816 1653 2800 CTCF MAZ MAX REST YY1 ZFHX2 GATA3 SMARCA4 POLR2A IKZF1

Genomic Location for CD200 Gene

Chromosome:
3
Start:
112,332,347 bp from pter
End:
112,362,812 bp from pter
Size:
30,466 bases
Orientation:
Plus strand

Genomic View for CD200 Gene

Genes around CD200 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD200 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200 Gene

Proteins for CD200 Gene

  • Protein details for CD200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41217-OX2G_HUMAN
    Recommended name:
    OX-2 membrane glycoprotein
    Protein Accession:
    P41217
    Secondary Accessions:
    • B3KQI1
    • B4DLW9
    • D3DN65
    • Q6J2Q6
    • Q6PIQ4
    • Q8TB85
    • Q9H3J3

    Protein attributes for CD200 Gene

    Size:
    278 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.

    Alternative splice isoforms for CD200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200 Gene

Post-translational modifications for CD200 Gene

  • Glycosylation at Asn 95, Asn 103, Asn 110, Asn 157, Asn 181, and Asn 190
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CD200

No data available for DME Specific Peptides for CD200 Gene

Domains & Families for CD200 Gene

Suggested Antigen Peptide Sequences for CD200 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41217

UniProtKB/Swiss-Prot:

OX2G_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD200: view

Function for CD200 Gene

Molecular function for CD200 Gene

UniProtKB/Swiss-Prot Function:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Gene Ontology (GO) - Molecular Function for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 21982860
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with CD200: view
genes like me logo Genes that share phenotypes with CD200: view

Animal Models for CD200 Gene

MGI Knock Outs for CD200:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD200 Gene

Localization for CD200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD200 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3032785
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD200: view

Pathways & Interactions for CD200 Gene

genes like me logo Genes that share pathways with CD200: view

Pathways by source for CD200 Gene

Gene Ontology (GO) - Biological Process for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0043031 negative regulation of macrophage activation IEA --
GO:0050776 regulation of immune response IEA,TAS --
genes like me logo Genes that share ontologies with CD200: view

No data available for SIGNOR curated interactions for CD200 Gene

Transcripts for CD200 Gene

Unigene Clusters for CD200 Gene

CD200 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14:
SP15: - - -
SP16: - - - - - - -
SP17:

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - -
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CD200 Gene

GeneLoc Exon Structure for
CD200
ECgene alternative splicing isoforms for
CD200

Expression for CD200 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD200 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for CD200 Gene

This gene is overexpressed in Placenta (31.5), Frontal cortex (12.6), and Fetal Brain (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD200 Gene



Protein tissue co-expression partners for CD200 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD200 Gene:

CD200

SOURCE GeneReport for Unigene cluster for CD200 Gene:

Hs.79015
genes like me logo Genes that share expression patterns with CD200: view

No data available for mRNA Expression by UniProt/SwissProt for CD200 Gene

Orthologs for CD200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD200 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia CD200 34 35
  • 84.79 (n)
dog
(Canis familiaris)
Mammalia CD200 34 35
  • 82.83 (n)
mouse
(Mus musculus)
Mammalia Cd200 34 16 35
  • 81.75 (n)
rat
(Rattus norvegicus)
Mammalia Cd200 34
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia CD200 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD200 34 35
  • 53.68 (n)
lizard
(Anolis carolinensis)
Reptilia CD200 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CD200 (1 of 3) 35
  • 17 (a)
OneToMany
CD200 (2 of 3) 35
  • 15 (a)
OneToMany
CD200 (3 of 3) 35
  • 15 (a)
OneToMany
Species where no ortholog for CD200 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD200 Gene

ENSEMBL:
Gene Tree for CD200 (if available)
TreeFam:
Gene Tree for CD200 (if available)

Paralogs for CD200 Gene

No data available for Paralogs for CD200 Gene

Variants for CD200 Gene

Sequence variations from dbSNP and Humsavar for CD200 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1050572 -- 112,347,715(+) ACCAC(A/G)TCTGT nc-transcript-variant, reference, synonymous-codon
rs10511311 -- 112,336,992(+) CTATA(A/T)TTTTT intron-variant
rs10595493 -- 112,352,566(+) GAGAG(-/AG)TGTTT intron-variant, utr-variant-3-prime
rs10663367 -- 112,360,325(+) TCATC(-/TAAAAA)TAAAA intron-variant
rs10804500 -- 112,331,210(+) TTCCA(A/G)TTTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD200 Gene

Variant ID Type Subtype PubMed ID
nsv591293 CNV loss 21841781
nsv10307 CNV gain 18304495

Variation tolerance for CD200 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD200 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200 Gene

Disorders for CD200 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CD200 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
mantle cell lymphoma
  • lymphoma, mantle cell
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
hypotropia
- elite association - COSMIC cancer census association via MalaCards
Search CD200 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD200

Genetic Association Database (GAD)
CD200
Human Genome Epidemiology (HuGE) Navigator
CD200
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD200
genes like me logo Genes that share disorders with CD200: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD200 Gene

Publications for CD200 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. CD200: a putative therapeutic target in cancer. (PMID: 18060862) Moreaux J. … Klein B. (Biochem. Biophys. Res. Commun. 2008) 3 22 64
  3. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. (PMID: 15699757) Chen D.X. … Gorczynski R.M. (Transplantation 2005) 3 22 64
  4. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. (PMID: 16177086) Shiratori I. … Arase H. (J. Immunol. 2005) 3 22 64
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64

Products for CD200 Gene

Sources for CD200 Gene

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