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Aliases for CD200 Gene

Aliases for CD200 Gene

  • CD200 Molecule 2 3
  • CD200 Antigen 2 3 4
  • MOX2 3 4 6
  • Antigen Identified By Monoclonal Antibody MRC OX-2 2 3
  • MOX1 3 4
  • OX-2 Membrane Glycoprotein 3
  • MRC OX-2 Antigen 3
  • OX-2 3
  • MRC 3

External Ids for CD200 Gene

Previous Symbols for CD200 Gene

  • MOX1
  • MOX2

Summaries for CD200 Gene

Entrez Gene Summary for CD200 Gene

  • The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD200 Gene

CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include chronic lymphocytic leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

UniProtKB/Swiss-Prot for CD200 Gene

  • Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

Gene Wiki entry for CD200 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD200 Gene

Genomics for CD200 Gene

Genomic Location for CD200 Gene

Start:
112,332,347 bp from pter
End:
112,362,812 bp from pter
Size:
30,466 bases
Orientation:
Plus strand

Genomic View for CD200 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD200 Gene

Regulatory Elements for CD200 Gene

Proteins for CD200 Gene

  • Protein details for CD200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41217-OX2G_HUMAN
    Recommended name:
    OX-2 membrane glycoprotein
    Protein Accession:
    P41217
    Secondary Accessions:
    • B3KQI1
    • B4DLW9
    • D3DN65
    • Q6J2Q6
    • Q6PIQ4
    • Q8TB85
    • Q9H3J3

    Protein attributes for CD200 Gene

    Size:
    278 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • CD200 and CD200R1 interact via their respective N-terminal Ig-like domains

    Alternative splice isoforms for CD200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD200 Gene

Proteomics data for CD200 Gene at MOPED

Post-translational modifications for CD200 Gene

  • Glycosylation at Asn95, Asn103, Asn110, Asn157, Asn181, and Asn190

Other Protein References for CD200 Gene

No data available for DME Specific Peptides for CD200 Gene

Domains for CD200 Gene

Gene Families for CD200 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD200 Gene

Suggested Antigen Peptide Sequences for CD200 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41217

UniProtKB/Swiss-Prot:

OX2G_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • P41217
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P41217
genes like me logo Genes that share domains with CD200: view

Function for CD200 Gene

Molecular function for CD200 Gene

UniProtKB/Swiss-Prot Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues

Gene Ontology (GO) - Molecular Function for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD200: view
genes like me logo Genes that share phenotypes with CD200: view

Animal Models for CD200 Gene

MGI Knock Outs for CD200:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD200 Gene

Localization for CD200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD200 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD200 Gene COMPARTMENTS Subcellular localization image for CD200 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3032785
genes like me logo Genes that share ontologies with CD200: view

Pathways for CD200 Gene

genes like me logo Genes that share pathways with CD200: view

Pathways by source for CD200 Gene

Gene Ontology (GO) - Biological Process for CD200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD200: view

Transcripts for CD200 Gene

Unigene Clusters for CD200 Gene

CD200 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13:
SP14:
SP15: - - -
SP16: - - - - - - -
SP17:

ExUns: 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - -
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CD200 Gene

GeneLoc Exon Structure for
CD200
ECgene alternative splicing isoforms for
CD200

Expression for CD200 Gene

mRNA expression in normal human tissues for CD200 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD200 Gene

This gene is overexpressed in Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD200 Gene

SOURCE GeneReport for Unigene cluster for CD200 Gene Hs.79015

genes like me logo Genes that share expressions with CD200: view

No data available for mRNA Expression by UniProt/SwissProt for CD200 Gene

Orthologs for CD200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD200 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD200 35
  • 99.62 (n)
  • 99.62 (a)
CD200 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD200 35
  • 84.79 (n)
  • 80.23 (a)
CD200 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD200 35
  • 82.83 (n)
  • 77.27 (a)
CD200 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd200 35
  • 81.75 (n)
  • 77.57 (a)
Cd200 16
Cd200 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD200 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd200 35
  • 80.61 (n)
  • 76.81 (a)
chicken
(Gallus gallus)
Aves CD200 35
  • 53.68 (n)
  • 40 (a)
CD200 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD200 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CD200 (1 of 3) 36
  • 17 (a)
OneToMany
CD200 (2 of 3) 36
  • 15 (a)
OneToMany
CD200 (3 of 3) 36
  • 15 (a)
OneToMany
Species with no ortholog for CD200:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD200 Gene

ENSEMBL:
Gene Tree for CD200 (if available)
TreeFam:
Gene Tree for CD200 (if available)

Paralogs for CD200 Gene

No data available for Paralogs for CD200 Gene

Variants for CD200 Gene

Sequence variations from dbSNP and Humsavar for CD200 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1050572 -- 112,347,715(+) ACCAC(A/G)TCTGT synonymous-codon, reference, downstream-variant-500B, nc-transcript-variant
rs1131199 - 112,340,921(+) CTTCT(C/G)TCATC reference, missense, intron-variant, utr-variant-5-prime, nc-transcript-variant
rs1317243 -- 112,334,399(+) TTTGA(C/T)CGATT intron-variant
rs1317244 -- 112,334,718(+) TGGTC(A/G)TATTT intron-variant
rs2272022 - 112,345,003(-) AGCAG(G/T)TGTGT missense, reference, utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CD200 Gene

Variant ID Type Subtype PubMed ID
nsv10307 CNV Gain 18304495
nsv877341 CNV Gain 21882294

Relevant External Links for CD200 Gene

HapMap Linkage Disequilibrium report
CD200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD200 Gene

Disorders for CD200 Gene

(1) Novoseek inferred disease relationships for CD200 Gene

Disease -log(P) Hits PubMed IDs
miscarriage 41 1

Relevant External Links for CD200

Genetic Association Database (GAD)
CD200
Human Genome Epidemiology (HuGE) Navigator
CD200
genes like me logo Genes that share disorders with CD200: view

No data available for UniProtKB/Swiss-Prot for CD200 Gene

Publications for CD200 Gene

  1. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. (PMID: 12960329) Wright G.J. … Barclay A.N. (J. Immunol. 2003) 3 23
  2. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. (PMID: 11260322) Wright G.J. … Barclay A.N. (Immunology 2001) 3 23
  3. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. (PMID: 15699757) Chen D.X. … Gorczynski R.M. (Transplantation 2005) 3 23
  4. CD200: a putative therapeutic target in cancer. (PMID: 18060862) Moreaux J. … Klein B. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for CD200 Gene

Sources for CD200 Gene

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