Aliases for CD2 Gene
External Ids for CD2 Gene
Previous HGNC Symbols for CD2 Gene
Previous GeneCards Identifiers for CD2 Gene
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
GeneCards Summary for CD2 Gene
CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus. Among its related pathways are Hematopoietic cell lineage and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include protein homodimerization activity and receptor activity.
UniProtKB/Swiss-Prot for CD2 Gene
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.