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Aliases for CD2 Gene

Aliases for CD2 Gene

  • CD2 Molecule 2 3
  • CD2 Antigen (P50), Sheep Red Blood Cell Receptor 2 3
  • T-Cell Surface Antigen T11/Leu-5 3 4
  • Erythrocyte Receptor 3 4
  • Rosette Receptor 3 4
  • LFA-3 Receptor 3 4
  • LFA-2 3 4
  • SRBC 3 4
  • Lymphocyte-Function Antigen-2 3
  • T-Cell Surface Antigen CD2 3
  • CD2 Antigen 4
  • T11 3

External Ids for CD2 Gene

Previous Symbols for CD2 Gene

  • SRBC

Summaries for CD2 Gene

Entrez Gene Summary for CD2 Gene

  • CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

GeneCards Summary for CD2 Gene

CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include lepromatous leprosy and familial chronic lymphocytic leukemia. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and receptor activity.

UniProtKB/Swiss-Prot for CD2 Gene

  • CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function

Gene Wiki entry for CD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD2 Gene

Genomics for CD2 Gene

Genomic Location for CD2 Gene

Start:
116,754,385 bp from pter
End:
116,769,229 bp from pter
Size:
14,845 bases
Orientation:
Plus strand

Genomic View for CD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD2 Gene

Regulatory Elements for CD2 Gene

Proteins for CD2 Gene

  • Protein details for CD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06729-CD2_HUMAN
    Recommended name:
    T-cell surface antigen CD2
    Protein Accession:
    P06729
    Secondary Accessions:
    • Q96TE5

    Protein attributes for CD2 Gene

    Size:
    351 amino acids
    Molecular mass:
    39448 Da
    Quaternary structure:
    • Interacts with CD2AP (By similarity). Interacts with PSTPIP1.

    Three dimensional structures from OCA and Proteopedia for CD2 Gene

neXtProt entry for CD2 Gene

Proteomics data for CD2 Gene at MOPED

Post-translational modifications for CD2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys264 and Lys310
  • Glycosylation at Asn89, Asn141, and Asn150

Other Protein References for CD2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD2 Gene

Domains for CD2 Gene

Gene Families for CD2 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Protein Domains for CD2 Gene

UniProtKB/Swiss-Prot:

CD2_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • P06729
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P06729
genes like me logo Genes that share domains with CD2: view

Function for CD2 Gene

Molecular function for CD2 Gene

GENATLAS Biochemistry: cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by monoclonal antibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen recognition via its role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by TCR,interacting with an adaptor protein (CDC2BP) to trigger cell adhesion,including a 3 locus control region LCR-CD2
UniProtKB/Swiss-Prot Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function

Gene Ontology (GO) - Molecular Function for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 7544493
GO:0005102 receptor binding IPI 17344209
GO:0005515 protein binding IPI 12356317
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CD2: view

Phenotypes for CD2 Gene

MGI mutant phenotypes for CD2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CD2: view

Animal Models for CD2 Gene

MGI Knock Outs for CD2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD2 Gene

Localization for CD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD2 Gene COMPARTMENTS Subcellular localization image for CD2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 2
peroxisome 2
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7544493
GO:0005911 cell-cell junction IEA --
GO:0009897 external side of plasma membrane IDA 21460847
genes like me logo Genes that share ontologies with CD2: view

Pathways for CD2 Gene

genes like me logo Genes that share pathways with CD2: view

Pathways by source for CD2 Gene

Gene Ontology (GO) - Biological Process for CD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization TAS 11376005
GO:0006915 apoptotic process TAS 10575274
GO:0007155 cell adhesion --
GO:0007166 cell surface receptor signaling pathway TAS 10575274
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with CD2: view

Compounds for CD2 Gene

(2) Drugbank Compounds for CD2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alefacept
222535-22-0 target inhibitor
Alpha-D-Mannose
3458-28-4 target

(15) Novoseek inferred chemical compound relationships for CD2 Gene

Compound -log(P) Hits PubMed IDs
aerolysin 62.4 2
sialic acid 38.2 2
tyrosine 32.8 14
c-peptide 29.4 3
ionomycin 23.6 1
genes like me logo Genes that share compounds with CD2: view

Transcripts for CD2 Gene

mRNA/cDNA for CD2 Gene

Unigene Clusters for CD2 Gene

CD2 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for CD2 Gene

GeneLoc Exon Structure for
CD2
ECgene alternative splicing isoforms for
CD2

Expression for CD2 Gene

mRNA expression in normal human tissues for CD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD2 Gene

This gene is overexpressed in Whole Blood (21.9), Spleen (7.1), and Small Intestine - Terminal Ileum (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD2 Gene

SOURCE GeneReport for Unigene cluster for CD2 Gene Hs.523500

genes like me logo Genes that share expressions with CD2: view

Orthologs for CD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD2 36
  • 99.62 (n)
  • 99.43 (a)
CD2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD2 36
  • 71.22 (n)
  • 54.9 (a)
CD2 37
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD2 36
  • 73.45 (n)
  • 60.18 (a)
CD2 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd2 36
  • 67.25 (n)
  • 52.65 (a)
Cd2 16
Cd2 37
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD2 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd2 36
  • 69.35 (n)
  • 57.14 (a)
chicken
(Gallus gallus)
Aves CD2 36
  • 50.23 (n)
  • 34.72 (a)
CD2 37
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487379 36
  • 44.9 (n)
  • 30.95 (a)
Species with no ortholog for CD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD2 Gene

ENSEMBL:
Gene Tree for CD2 (if available)
TreeFam:
Gene Tree for CD2 (if available)

Paralogs for CD2 Gene

No data available for Paralogs for CD2 Gene

Variants for CD2 Gene

Sequence variations from dbSNP and Humsavar for CD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs699738 - 116,768,525(-) ATTTG(G/T)TGGGG missense, reference
rs797998 -- 116,755,164(-) AGAGT(C/T)GTAGG intron-variant
rs798034 -- 116,769,497(-) AGACC(C/T)AAAAT downstream-variant-500B
rs798035 -- 116,767,385(-) CGAAC(C/T)CCCGA intron-variant
rs798036 -- 116,766,208(-) CAGGA(A/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD2 Gene

Variant ID Type Subtype PubMed ID
nsv831148 CNV Gain 17160897
nsv2555 CNV Insertion 18451855
esv2716618 CNV Deletion 23290073

Relevant External Links for CD2 Gene

HapMap Linkage Disequilibrium report
CD2
Human Gene Mutation Database (HGMD)
CD2

Disorders for CD2 Gene

(2) University of Copenhagen DISEASES for CD2 Gene

(18) Novoseek inferred disease relationships for CD2 Gene

Disease -log(P) Hits PubMed IDs
malaria 45.4 8
mastocytosis 22.7 1
thymoma 19.2 1
necrosis 9.9 4
insulin resistance 8.78 2

Relevant External Links for CD2

Genetic Association Database (GAD)
CD2
Human Genome Epidemiology (HuGE) Navigator
CD2
genes like me logo Genes that share disorders with CD2: view

No data available for UniProtKB/Swiss-Prot for CD2 Gene

Publications for CD2 Gene

  1. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PMID: 2437578) Seed B. … Aruffo A. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4
  2. Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2). (PMID: 2444890) Peterson A. … Seed B. (Nature 1987) 3 4
  3. Conformation and function of the N-linked glycan in the adhesion domain of human CD2. (PMID: 7544493) Wyss D.F. … Wagner G. (Science 1995) 3 4
  4. Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. (PMID: 2883656) Sayre P.H. … Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  5. Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (PMID: 2894031) Diamond D.J. … Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1988) 3 4

Products for CD2 Gene

  • Addgene plasmids for CD2

Sources for CD2 Gene

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