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CD2 Gene

protein-coding   GIFtS: 67
GCID: GC01P117297

CD2 Molecule

(Previous names: CD2 antigen (p50), sheep red blood cell receptor)
(Previous symbol: SRBC)
  See CD2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD2 Molecule1 2     LFA-3 Receptor2 3
SRBC1 2 3     T-Cell Surface Antigen T11/Leu-52 3
CD2 Antigen (P50), Sheep Red Blood Cell Receptor1 2     T112
Erythrocyte Receptor2 3     Lymphocyte-Function Antigen-22
Rosette Receptor2 3     T-Cell Surface Antigen CD22
LFA-22 3     CD2 Antigen3

External Ids:    HGNC: 16391   Entrez Gene: 9142   Ensembl: ENSG000001168247   OMIM: 1869905   UniProtKB: P067293   

Export aliases for CD2 gene to outside databases

Previous GC identifers: GC01P117800 GC01P116179 GC01P116444 GC01P116643 GC01P117009 GC01P117098 GC01P115156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD2 Gene:
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells
(summarized by Sewell et al., 1986 (PubMed 3490670)). It is one of the earliest T-cell markers, being present on
more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal
antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is
the erythrocyte receptor or is closely associated with it.(supplied by OMIM, Jul 2010)

GeneCards Summary for CD2 Gene:
CD2 (CD2 molecule) is a protein-coding gene. Diseases associated with CD2 include lepromatous leprosy, and familial chronic lymphocytic leukemia. GO annotations related to this gene include receptor activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729
Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion
between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is
implicated in the signaling function

Gene Wiki entry for CD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD2 gene promoter:
         Max1   Pax-5   AML1a   STAT5A   IRF-1   E47   CREB   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD2 promoter sequence
   Search Chromatin IP Primers for CD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

CD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117297:  view genomic region     (about GC identifiers)

Start:
117,297,007 bp from pter      End:
117,311,851 bp from pter
Size:
14,845 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD2_HUMAN, P06729 (See protein sequence)
Recommended Name: T-cell surface antigen CD2 precursor  
Size: 351 amino acids; 39448 Da
Subunit: Interacts with CD2AP (By similarity). Interacts with PSTPIP1
Selected PDB 3D structures from and Proteopedia for CD2 (see all 7):
1CDB (3D)        1GYA (3D)        1HNF (3D)        1L2Z (3D)        1QA9 (3D)        2J6O (3D)    
Secondary accessions: Q96TE5

Explore the universe of human proteins at neXtProt for CD2: NX_P06729

Explore proteomics data for CD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys264, Lys310
  • Glycosylation2 at Asn89, Asn141, Asn150
  • Modification sites at PhosphoSitePlus

  • See CD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001758.2  
    ENSEMBL proteins: 
     ENSP00000358490   ENSP00000358489  
    Reactome Protein details: P06729

    CD2 Human Recombinant Protein Products:

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    Novus Biologicals CD2 Proteins
    Novus Biologicals CD2 Lysates
    Sino Biological Recombinant Protein for CD2
    Sino Biological Cell Lysate for CD2
    ProSpec Recombinant Protein for CD2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD2 

     
    antibodies-online proteins for CD2 (25 products) 

     
    antibodies-online peptides for CD2

    CD2 Antibody Products:

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    antibodies-online antibodies for CD2 (397 products) 

    CD2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD2 
    antibodies-online kits for CD2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR015632 CD2
     IPR008424 Ig_C2-set
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry P06729

    ProtoNet protein and cluster: P06729

    1 Blocks protein domain: IPB008424 T-cell surface antigen CD2

    UniProtKB/Swiss-Prot: CD2_HUMAN, P06729
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD2_HUMAN, P06729
    Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion
    between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is
    implicated in the signaling function

         Genatlas biochemistry entry for CD2:
    cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by
    monoclonal antibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen
    recognition via its role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by
    TCR,interacting with an adaptor protein (CDC2BP) to trigger cell adhesion,including a 3' locus control region
    LCR-CD2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS7544493
    GO:0005102receptor binding IPI17344209
    GO:0005515protein binding IPI12356317
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with CD2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cd2):
     normal 

    Find genes that share phenotypes with CD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd2tm1Litt for CD2

       genOway: Develop your customized and physiologically relevant rodent model for CD2

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CD2:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CD2 (NM_005164)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD2
    Addgene plasmids for CD2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD2_HUMAN, P06729: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    extracellular2
    peroxisome2
    chloroplast1
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS7544493
    GO:0009897external side of plasma membrane IDA--
    GO:0009898cytoplasmic side of plasma membrane IEA--

    Find genes that share ontologies with CD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD2 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with CD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD2 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    1 Reactome Pathway for CD2
        Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for CD2):
        Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD2 (see all 7): 
              Cell Surface Markers in human mouse rat
              Th17 Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CD2 (P067291, 2, 3 ENSP000003584904) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2BP2O954001, 2, 3, ENSP000003049034EBI-3912464,EBI-768015 MINT-50471 MINT-50457 MINT-15125 MINT-62665 MINT-50559 MINT-62656 MINT-62832 MINT-18223 MINT-62660 MINT-62648 MINT-62661 MINT-50473 MINT-62666 MINT-50470 MINT-50472 MINT-62819 I2D: score=4 STRING: ENSP00000304903
    CD2APQ9Y5K61, 2, 3, ENSP000003522644EBI-3912464,EBI-298152 MINT-51118 MINT-51119 MINT-7041387 I2D: score=4 STRING: ENSP00000352264
    FYNP062412, 3, ENSP000003576564MINT-50661 MINT-50664 MINT-50663 MINT-50665 I2D: score=5 STRING: ENSP00000357656
    LCKP062392, 3, ENSP000003378254MINT-50662 I2D: score=4 STRING: ENSP00000337825
    SH3KBP1Q96B971, 3, ENSP000003809214EBI-3912464,EBI-346595 I2D: score=3 STRING: ENSP00000380921
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    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001766membrane raft polarization TAS11376005
    GO:0006915apoptotic process TAS10575274
    GO:0007155cell adhesion ----
    GO:0007166cell surface receptor signaling pathway TAS10575274
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with CD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD2

    2 DrugBank Compounds for CD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alefacept-- 222535-22-0targetinhibitor17403057 17555598 14968366 11752352 12795770 11970990
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for CD2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aerolysin 62.4 2 2158347 (1), 9282746 (1)
    sialic acid 38.2 2 9584138 (1), 8557359 (1)
    tyrosine 32.8 19 1372020 (2), 8557753 (2), 11166460 (1), 10580638 (1) (see all 12)
    c-peptide 29.4 3 9670112 (1), 15247957 (1), 10631198 (1)
    ionomycin 23.6 1 11123293 (1)
    fructosamine 22.9 3 8755851 (3)
    cyclosporin a 20.4 2 1676547 (1)
    con a 16.3 1 7532641 (1)
    wortmannin 12.4 4 8557753 (1), 11932928 (1)
    proline 7.97 1 10430626 (1)



    Find genes that share compounds with CD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD2 gene: 
    NM_001767.3  

    Unigene Cluster for CD2:

    CD2 molecule
    Hs.523500  [show with all ESTs]
    Unigene Representative Sequence: AK127925
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369478(uc010owz.1 uc010oxa.1 uc001egu.4) ENST00000369477

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      QuantiFast Probe-based Assays in human, mouse, rat CD2

    Additional mRNA sequence: 

    AK127925.1 AK223393.1 AK301154.1 AK303367.1 AK310676.1 AK313614.1 BC033583.1 M14362.1 
    M16336.1 M16445.1 

    5 DOTS entries:

    DT.111078  DT.97835608  DT.97835609  DT.86850751  DT.91664505 

    Selected AceView cDNA sequences (see all 49):

    NM_001767 BM821729 AA356532 BE503151 BQ028759 BX100790 M16445 CR608242 
    AI290326 BC033583 M16336 AL712654 CA438480 AI702265 AA927710 BX456944 
    CD691699 AI358549 BI833341 CD700090 CD709745 AW191960 BM920483 M14362 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CD2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:                                      -           -     -                     
    SP2:                                      -           -                           
    SP3:                                      -                                       
    SP4:                                -     -           -     -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for CD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGATGCG
    CD2 Expression
    About this image


    CD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 13 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 4 entries
             T Helper Cells Thymus
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
    CD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523500
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD2 (see all 7): 
              Cell Surface Markers in human mouse rat
              Th17 Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd21 , 5 CD2 antigen1, 5 67.25(n)1
    52.65(a)1
      3 (44.17 cM)5
    124811  NM_013486.21  NP_038514.11 
     1012758995 
    chicken
    (Gallus gallus)
    Aves CD21 CD2 molecule 50.23(n)
    34.72(a)
      768858  XM_001232012.2  XP_001232013.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004873791 T-cell surface antigen CD2-like 44.9(n)
    30.95(a)
      100487379  XM_002943690.2  XP_002943736.1 


    ENSEMBL Gene Tree for CD2 (if available)
    TreeFam Gene Tree for CD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD2 (see all 402)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355044
    A breast cancer sample4--see VAR_0355042 C Y mis40--------
    rs1426202111,2
    --117295102(+) TCCCCA/CGAAGG 1 -- us2k10--------
    rs1468972701,2
    --117295212(+) ATGGTA/GAAAAA 1 -- us2k10--------
    rs355991061,2
    C--117295245(+) ATACAT/CATATT 1 -- us2k13Minor allele frequency- C:0.17NA WA 240
    rs1126763421,2
    F--117295295(+) TTCTGC/TGAAAT 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120
    rs1827111331,2
    --117295296(+) TCTGCA/GAAATA 1 -- us2k10--------
    rs1877772251,2
    C--117295324(+) TCATTC/TATATC 1 -- us2k10--------
    rs2013023341,2
    --117295325(+) CATTT-/ATATCA 1 -- us2k10--------
    rs1393690511,2
    --117295356(+) CTTTGC/TATTGA 1 -- us2k10--------
    rs1417102811,2
    --117295410(+) TTATAA/TATATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD2 (117297007 - 117311851 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716618CNV Deletion23290073
    nsv2555CNV Insertion18451855
    nsv831148CNV Gain17160897

    Human Gene Mutation Database (HGMD): CD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD2
    DNA2.0 Custom Variant and Variant Library Synthesis for CD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186990    OMIM disorders: --

    10 diseases for CD2:    
    About MalaCards
    lepromatous leprosy    familial chronic lymphocytic leukemia    primary effusion lymphoma    systemic mastocytosis
    thymoma    mastocytosis    leprosy    squamous cell carcinoma of the head and neck
    essential hypertension    malaria

    2 diseases from the University of Copenhagen DISEASES database for CD2:
    Malaria     Leukemia

    Find genes that share disorders with CD2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malaria 45.4 9 7689250 (1), 17470537 (1), 19519483 (1), 9199449 (1) (see all 8)
    mastocytosis 22.7 1 11919419 (1)
    thymoma 19.2 1 1385156 (1)
    necrosis 9.9 4 1359970 (2), 7488336 (1), 8095456 (1)
    insulin resistance 8.78 2 10631198 (1), 9082345 (1)
    skin lesion 0 1 7512116 (1)
    lupus erythematosus systemic 0 2 1673843 (1), 10399227 (1)
    leukemia 0 1 8350618 (1)
    virus infection 0 1 7754234 (1)
    essential hypertension 0 5 10697394 (3), 8807554 (2)

    Genetic Association Database (GAD): CD2
    Human Genome Epidemiology (HuGE) Navigator: CD2 (5 documents)

    Export disorders for CD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD2 gene, integrated from 10 sources (see all 320):
    (articles sorted by number of sources associating them with CD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PubMed id 2437578)1, 2, 3 Seed B. and Aruffo A. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. (PubMed id 9857189)1, 2 Li J.... Reinherz E.L. (EMBO J. 1998)
    6. Conformation and function of the N-linked glycan in the adhesion domain of human CD2. (PubMed id 7544493)1, 2 Wyss D.F.... Wagner G. (Science 1995)
    7. Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution. (PubMed id 7994575)1, 2 Bodian D.L.... Davis S.J. (Structure 1994)
    8. Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. (PubMed id 7915183)1, 2 Withka J.M....Recny M.A. (Structure 1993)
    9. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. (PubMed id 1377404)1, 2 Hahn W.C.... Bierer B.E. (Science 1992)
    10. Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (PubMed id 2894031)1, 2 Diamond D.J.... Reinherz E.L. (Proc. Natl. Acad. Sci. U.S.A. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 914 HGNC: 1639 AceView: CD2 Ensembl:ENSG00000116824 euGenes: HUgn914
    ECgene: CD2 Kegg: 914 H-InvDB: CD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD2 gene:
    Search GeneIP for patents involving CD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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