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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD2 Gene

protein-coding GIFtS: 65
GCID: GC01P117297

CD2 molecule

(Previous names: CD2 antigen (p50), sheep red blood cell receptor )
(Previous symbol: SRBC)

Explore 43 diseases affiliated with
CD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD2 Molecule¹ ²		LFA-3 Receptor² ³
SRBC¹ ² ³		T-Cell Surface Antigen T11/Leu-5² ³
CD2 Antigen (P50), Sheep Red Blood Cell Receptor¹ ²		T11²
Erythrocyte Receptor² ³		Lymphocyte-Function Antigen-2²
Rosette Receptor² ³		T-Cell Surface Antigen CD2²
LFA-2² ³		CD2 Antigen³

External Ids:	HGNC: 1639¹	Entrez Gene: 914²	Ensembl: ENSG00000116824⁷	OMIM: 186990⁵	UniProtKB: P06729³

Export aliases for CD2 gene to outside databases

Previous GC identifers: GC01P117800 GC01P116179 GC01P116444 GC01P116643 GC01P117009 GC01P117098 GC01P115156

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD2:

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells

(summarized by Sewell et al., 1986 (PubMed 3490670)). It is one of the earliest T-cell markers, being present on more

than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies

directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte

receptor or is closely associated with it.(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729

Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between

T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in

the signaling function

Gene Wiki entry for CD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD2 gene promoter:
Max1 Pax-5 AML1a STAT5A IRF-1 E47 CREB deltaCREB c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD2 promoter sequence

Search SABiosciences Chromatin IP Primers for CD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13

CD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P117297: view genomic region (about GC identifiers)

Start:	117,297,007 bp from pter	End:	117,311,851 bp from pter
Size:	14,845 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729 (See protein sequence)

Recommended Name: T-cell surface antigen CD2 precursor

Size: 351 amino acids; 39448 Da

Subunit: Interacts with CD2AP (By similarity). Interacts with PSTPIP1

Subcellular location: Membrane; Single-pass type I membrane protein

6/7 PDB 3D structures from and Proteopedia for CD2 (see all 7):

1CDB (3D)

1GYA (3D)

1HNF (3D)

1L2Z (3D)

1QA9 (3D)

2J6O (3D)

Secondary accessions: Q96TE5

Explore the universe of human proteins at neXtProt for CD2: NX_P06729

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06729

CD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001758.2

ENSEMBL proteins:

ENSP00000358490 ENSP00000358489

Reactome Protein details: P06729
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CD2 Proteins Novus Biologicals CD2 Lysates
	Sino Biological Recombinant Protein for CD2
	ProSpec Recombinant Protein for CD2
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	7544493
GO:0009897	external side of plasma membrane	IDA	--
GO:0009898	internal side of plasma membrane	IEA	--

CD2 for ontologies About GeneDecksing

CD2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD2
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	GenScript Superior Antibodies for CD2
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	Abcam antibodies for CD2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for CD2

Assay Products for CD2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD2 for domains About GeneDecksing

5 InterPro domains/families:

IPR015632 T-cell_sdhesion_molc_CD2

IPR008424 Ig_C2-set

IPR015631 SLAM_fam_rcpts

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P06729

ProtoNet protein and cluster: P06729

1 Blocks protein family: IPB008424 T-cell surface antigen CD2

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729

Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between

T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in

the signaling function

Genatlas biochemistry entry for CD2:

cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by monoclonal

antibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen recognition via

its role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by TCR,interacting with

an adaptor protein (CDC2BP) to trigger cell adhesion,including a 3' locus control region LCR-CD2

miRNA Products:		OriGene 3'-UTR Clone: CD2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CD2:
		hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: CD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD2 (see all 7) OriGene shRNA RFP: CD2 OriGene siRNA: CD2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD2
		Search LifeMap BioReagents cell lines for CD2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	NAS	7544493
GO:0005515	protein binding	IPI	1970422
GO:0042803	protein homodimerization activity	IEA	--
GO:0043499	eukaryotic cell surface binding	IEA	--

CD2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cd2^tm1Litt for CD2
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cd2):

normal

CD2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD2 (see all 25)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 Reactome Pathways for CD2

	Hemostasis
	Cell surface interactions at the vascular wall

2 Kegg Pathways (Kegg details for CD2):

	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage

CD2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/24 Interacting proteins for CD2 (P06729^{2, 3} ENSP00000358490⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD2BP2	O95400²^,³, ENSP00000304903⁴	MINT-50471 MINT-50457 MINT-15125 MINT-62665 MINT-50559 MINT-62656 MINT-62832 MINT-18223 MINT-62660 MINT-62648 MINT-62661 MINT-50473 MINT-62666 MINT-50470 MINT-50472 MINT-62819 I2D: score=4 STRING: ENSP00000304903
FYN	P06241²^,³, ENSP00000357656⁴	MINT-50661 MINT-50664 MINT-50663 MINT-50665 I2D: score=5 STRING: ENSP00000357656
CD2AP	Q9Y5K6²^,³, ENSP00000352264⁴	MINT-51118 MINT-51119 MINT-7041387 I2D: score=4 STRING: ENSP00000352264
LCK	P06239²^,³, ENSP00000337825⁴	MINT-50662 I2D: score=4 STRING: ENSP00000337825
PSTPIP1	O43586²^,³, ENSP00000368914⁴	MINT-51107 MINT-51108 MINT-16704 MINT-51111 MINT-51114 I2D: score=4 STRING: ENSP00000368914

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001766	membrane raft polarization	TAS	11376005
GO:0006917	induction of apoptosis	TAS	10575274
GO:0007166	cell surface receptor signaling pathway	TAS	10575274
GO:0007596	blood coagulation	TAS	--
GO:0016337	cell-cell adhesion	NAS	7544493

CD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD2

2 DrugBank Compounds for CD2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alefacept	--	222535-22-0	target	inhibitor	17403057 17555598 14968366 11752352 12795770 11970990
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423

10/15 Novoseek chemical compound relationships for CD2 gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aerolysin	62.4	2	2158347 (1), 9282746 (1)
sialic acid	38.2	2	9584138 (1), 8557359 (1)
tyrosine	32.8	19	1372020 (2), 8557753 (2), 11166460 (1), 10580638 (1) (see all 12)
c-peptide	29.4	3	9670112 (1), 15247957 (1), 10631198 (1)
ionomycin	23.6	1	11123293 (1)
fructosamine	22.9	3	8755851 (3)
cyclosporin a	20.4	2	1676547 (1)
con a	16.3	1	7532641 (1)
wortmannin	12.4	4	8557753 (1), 11932928 (1)
proline	7.97	1	10430626 (1)

Search CenterWatch for drugs/clinical trials and news about CD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD2 gene:

NM_001767.3

Unigene Cluster for CD2:

CD2 molecule

Hs.523500 [show with all ESTs]

Unigene Representative Sequence: AK127925

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369478(uc010owz.1 uc010oxa.1 uc001egu.4) ENST00000369477

miRNA Products:		OriGene 3'-UTR Clone: CD2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CD2:
		hsa-miR-205*
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CD2 (NM_005164)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD2

Additional cDNA sequence:

AK127925.1 AK223393.1 AK301154.1 AK303367.1 AK310676.1 AK313614.1 BC033583.1 M14362.1

M16336.1 M16445.1

5 DOTS entries:

DT.111078 DT.97835608 DT.97835609 DT.86850751 DT.91664505

24/49 AceView cDNA sequences (see all 49):

BX100790 BE503151 CR608242 AI290326 NM_001767 BC033583 AA356532 M16445

BQ028759 BM821729 CD700090 CD709745 AA927710 CD691699 BM920483 AL712654

M14362 AI358549 M16336 BI833341 AI702265 AW191960 CA438480 BX456944

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CD2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	·	4c	^	5
SP1:													-				-		-
SP2:													-				-
SP3:													-
SP4:											-		-				-		-
SP5:

ECgene alternative splicing isoforms for CD2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAGATGCG

About this image

CD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Myeloid Dendritic Cells

Blood

Blood

Blood

Blood

Blood

Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD2

SOURCE GeneReport for Unigene cluster: Hs.523500

SABiosciences Expression via Pathway-Focused PCR Arrays including CD2 (see all 7):

Cell Surface Markers in human mouse rat

Th17 Response in human mouse rat

Antigen Presenting Cells in human mouse rat

Lymphoma in human mouse rat

Apoptosis 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD2 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd2^{1 , 5}	CD2 antigen^{1, 5}	67.25(n)¹ 52.65(a)¹		3 (44.17 cM)⁵ 12481¹ NM_013486.2¹ NP_038514.1¹ 101275899⁵
chicken (Gallus gallus)	Aves	CD2¹	CD2 molecule	51.34(n) 37.55(a)		768858 XM_001232012.1 XP_001232013.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-11f4.20⁶	si:dkey-11f4.20	20(a)	1 ↔ 1	9(3510-10659)

ENSEMBL Gene Tree for CD2 (if available)
TreeFam Gene Tree for CD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142620211^1,2		--	117295102(+)	`TCCCCA/CGAAGG`	1	--	us2k¹		0	--	--	--	--
rs146897270^1,2		--	117295212(+)	`ATGGTA/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs35599106^1,2	C,	--	117295245(+)	`NNNNAT/CATATT`	1	--	us2k¹		3		NA WA	240
rs112676342^1,2		--	117295295(+)	`TTCTGC/TGAAAT`	1	--	us2k¹		2		CSA WA	120
rs182711133^1,2		--	117295296(+)	`TCTGCA/GAAATA`	1	--	us2k¹		0	--	--	--	--
rs187777225^1,2		--	117295324(+)	`TCATTC/TATATC`	1	--	us2k¹		0	--	--	--	--
rs201302334^1,2		--	117295325(+)	`CATTT-/ATATCA`	1	--	us2k¹		0	--	--	--	--
rs139369051^1,2		--	117295356(+)	`CTTTGC/TATTGA`	1	--	us2k¹		0	--	--	--	--
rs141710281^1,2		--	117295410(+)	`TTATAA/TATATT`	1	--	us2k¹		0	--	--	--	--
rs190743338^1,2		--	117295577(+)	`ATCTTC/TCTATA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD2 (117297007 - 117311851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD2
1 CNV: 4243

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD2 for disorders           About GeneDecksing

OMIM gene information: 186990    OMIM disorders: --

20/43 diseases for CD2 (see all 43):    About MalaCards

hypersensitivity reaction type ii disease wiskott-aldrich syndrome lepromatous leprosy arteriosclerosis obliterans

familial chronic lymphocytic leukemia chronic lymphocytic leukemia primary effusion lymphoma lupus erythematosus

insulin resistance essential hypertension myocardial infarction retinal hemangioblastoma

squamous cell carcinoma of the head and neck mastocytosis systemic lupus erythematosus lymphocytic leukemia

squamous cell carcinoma arteriosclerosis atopic dermatitis multiple sclerosis

2 diseases from the University of Copenhagen DISEASES database for CD2:

Malaria Leukemia

10/18 Novoseek disease relationships for CD2 gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malaria	45.4	9	7689250 (1), 17470537 (1), 19519483 (1), 9199449 (1) (see all 8)
mastocytosis	22.7	1	11919419 (1)
thymoma	19.2	1	1385156 (1)
necrosis	9.9	4	1359970 (2), 7488336 (1), 8095456 (1)
insulin resistance	8.78	2	10631198 (1), 9082345 (1)
skin lesion	0	1	7512116 (1)
lupus erythematosus systemic	0	2	1673843 (1), 10399227 (1)
leukemia	0	1	8350618 (1)
virus infection	0	1	7754234 (1)
essential hypertension	0	5	10697394 (3), 8807554 (2)

Human Genome Epidemiology (HuGE) Navigator: CD2 (5 documents)

Export disorders for CD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD2 gene, integrated from 9 sources (see all 310):
(articles sorted by number of sources associating them with CD2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PubMed id 2437578)^{1, 2, 3} Seed B. and Aruffo A. (1987)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. (PubMed id 9857189)^{1, 2} Li J.... Reinherz E.L. (1998)
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. (PubMed id 7544493)^{1, 2} Wyss D.F.... Wagner G. (1995)
Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution. (PubMed id 7994575)^{1, 2} Bodian D.L.... Davis S.J. (1994)
Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. (PubMed id 7915183)^{1, 2} Withka J.M....Recny M.A. (1993)
Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. (PubMed id 1377404)^{1, 2} Hahn W.C.... Bierer B.E. (1992)
Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (PubMed id 2894031)^{1, 2} Diamond D.J.... Reinherz E.L. (1988)
The structure of the human CD2 gene and its expression in transgenic mice. (PubMed id 2901953)^{1, 2} Lang G.... Kioussis D. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 914	HGNC: 1639	AceView: CD2	Ensembl:ENSG00000116824	euGenes: HUgn914
ECgene: CD2	Kegg: 914	H-InvDB: CD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CD2

Intellectual Property for CD2 gene
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Patent Information for CD2 gene:
Search GeneIP for patents involving CD2

GeneCards and IP:
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