Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD1E Gene

protein-coding   GIFtS: 59
GCID: GC01P158323

CD1e molecule

(Previous names: CD1E antigen, e polypeptide, CD1e antigen )
 Explore 9 diseases affiliated with
CD1E via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD1E    

Aliases
for CD1E gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD1e Molecule1 2     R22
CD1E Antigen, E Polypeptide1 2     Differentiation Antigen CD1-Alpha-32
CD1e Antigen1 3     Leukocyte Differentiation Antigen2
R2G12 3     T-Cell Surface Glycoprotein CD1e, Membrane-Associated2
HCD1e1     Thymocyte Antigen CD1E2
CD1A2     

External Ids:    HGNC: 16381   Entrez Gene: 9132   Ensembl: ENSG000001584887   OMIM: 1884115   UniProtKB: P158123   

Export aliases for CD1E gene to outside databases

Previous GC identifers: GC01P156115 GC01P154056 GC01P155101 GC01P155540 GC01P155136 GC01P156590 GC01P129681


Summaries
for CD1E gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD1E:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins
mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human
genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to
differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene
localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble
form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1
family members. Many alternatively spliced transcript variants encoding different isoforms have been described.
Additional transcript variants have been found; however, their biological validity has not been determined. (provided
by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812
Function: T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell
surface. The membrane-associated form is not active

Gene Wiki entry for CD1E


Genomic Views
for CD1E gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD1E gene promoter:
         Bach1   SREBP-1c   MyoD   LCR-F1   E47   GATA-1   AREB6   CREB   deltaCREB   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD1E promoter sequence
   Search SABiosciences Chromatin IP Primers for CD1E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22-q23

CD1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1E gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158323:  view genomic region     (about GC identifiers)

Start:
 158,323,254 bp from pter      End:
 158,327,343 bp from pter
Size:
 4,090 bases      Orientation:
 plus strand

Proteins
for CD1E gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1e, membrane-associated precursor  
Size: 388 amino acids; 43626 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the
presence of the propeptide
Subcellular location: T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type
I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature
dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells
Subcellular location: T-cell surface glycoprotein CD1e, soluble: Lysosome lumen
Sequence caution: Sequence=CAA33100.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CD1E:
3S6C (3D)    
Secondary accessions: B4DZV3 Q5TDJ9 Q5TDK3 Q5TDK4 Q5TDK5 Q5TDK6 Q5TDK8 Q5TDL1 Q712E4 Q712E5 Q712E6
Q712E7 Q712E8 Q712E9 Q712F0 Q712F1 Q712F2 Q712F3 Q712F4 Q712F5 Q96TD0 Q96TD1 Q9UMM1 Q9Y5M3
Alternative splicing: 12 isoforms:  P15812-1   P15812-2   P15812-3   P15812-4   P15812-5   P15812-6   P15812-7   P15812-8   
P15812-9   P15812-10   P15812-11   P15812-12   

Explore the universe of human proteins at neXtProt for CD1E: NX_P15812

Post-translational modifications:

  • Mono-ubiquitinated1
  • Proteolytically cleaved in late endosomes to yield a soluble form1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15812

    • CD1E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (13 alternative transcripts): 
    NP_001036048.1  NP_001036049.1  NP_001036050.1  NP_001036051.1  NP_001036052.1  NP_001172036.1  NP_001172037.1  NP_001172039.1  
    NP_001172041.1  NP_001172042.1  NP_001172043.1  NP_001172044.1  NP_112155.2  

    ENSEMBL proteins: 
     ENSP00000357149   ENSP00000416228   ENSP00000357147   ENSP00000357148   ENSP00000357145  
     ENSP00000357146   ENSP00000357139   ENSP00000357138   ENSP00000357137   ENSP00000357136  
     ENSP00000357142   ENSP00000357143   ENSP00000357144   ENSP00000401957   ENSP00000402906  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 7): CD1E
    OriGene Custom Protein Services for CD1E 
    GenScript Custom Purified and Recombinant Proteins Services for CD1E
    Novus Biologicals CD1E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--
    GO:0005887integral to plasma membrane NAS2467814
    GO:0016020membrane ----


    CD1E for ontologies           About GeneDecksing



    CD1E Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD1E
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CD1E 
    GenScript Custom Superior Antibodies Services for CD1E
    Search for Antibodies for CD1E at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibody for CD1E

    Assay Products for CD1E: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD1E
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CD1E gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD1E for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry P15812

    ProtoNet protein and cluster: P15812

    1 Blocks protein family: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Function
    for CD1E gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812
    Function: T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell
    surface. The membrane-associated form is not active

         Genatlas biochemistry entry for CD1E:
    cell differentiation antigen CD1E (see CD1@)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD1E
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD1E:
    hsa-miR-3658 hsa-miR-205* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: CD1E 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD1E
    OriGene shRNA RFP: CD1E
    OriGene siRNA: CD1E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1E

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD1E

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E (see all 13)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 13): CD1E (NM_001042583)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD1E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1E 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD1E
    Search LifeMap BioReagents cell lines for CD1E

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1E

    1 GenomeRNAi human phenotype for CD1E:
     Increased 8N DNA content 


    Pathways & Interactions
    for CD1E gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Hematopoietic cell lineage
    		Hematopoietic cell lineage1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CD1E):
        Hematopoietic cell lineage


    CD1E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD1E

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD1E (P158123 ENSP000003571494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617693, ENSP000003408584I2D: score=1 STRING: ENSP00000340858
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS2467814
    GO:0019882antigen processing and presentation IEA--


    CD1E for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD1E gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD1E

    10/519 HMDB Compounds for CD1E (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    Search CenterWatch for drugs/clinical trials and news about CD1E 

    Transcripts
    for CD1E gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD1E gene (13 alternative transcripts): 
    NM_001042583.2  NM_001042584.2  NM_001042585.2  NM_001042586.2  NM_001042587.2  NM_001185107.1  NM_001185108.1  NM_001185110.1  
    NM_001185112.1  NM_001185113.1  NM_001185114.1  NM_001185115.1  NM_030893.3  

    Unigene Cluster for CD1E:

    CD1e molecule
    Hs.249217  [show with all ESTs]
    Unigene Representative Sequence: NM_030893
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368167 ENST00000452291 ENST00000368165 ENST00000368166 ENST00000368163(uc001fry.3 uc001fsj.3)
    ENST00000368164 ENST00000368157 ENST00000368156 ENST00000368155 ENST00000368154
    ENST00000368160 ENST00000368161 ENST00000464822 ENST00000368162 ENST00000434258(uc010pid.2 uc010pie.2)
    ENST00000444681(uc001fsd.3 uc001frz.3 uc010pig.2 uc001fsc.3 uc001fsh.3 uc001fse.3 uc001fsf.3 uc001fsg.3 uc009wsv.3 uc001fsk.3 uc001fsa.3 uc021pbm.1 uc009wsw.3)


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD1E
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD1E:
    hsa-miR-3658 hsa-miR-205* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: CD1E 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD1E
    OriGene shRNA RFP: CD1E
    OriGene siRNA: CD1E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1E
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E (see all 13)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 13): CD1E (NM_001042583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD1E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1E 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD1E
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD1E
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1E

    Additional cDNA sequence: 

    AJ289111.1 AJ289112.1 AJ289113.1 AJ289114.1 AJ289115.1 AJ289116.1 AJ289117.1 AJ289118.1 
    AJ289119.1 AJ289120.1 AJ289121.1 AJ289122.1 AK303088.1 AK303108.1 AK303217.1 AK303233.1 
    AK303542.1 AK310673.1 AK311643.1 BC131693.1 X79517.1 X79518.1 X79519.1 

    16 DOTS entries:

    DT.40228740  DT.100653437  DT.427460  DT.92419690  DT.95163686  DT.100829160  DT.100653438  DT.100653436 
    DT.100863952  DT.92419691  DT.100653439  DT.121426569  DT.40227468  DT.87046839  DT.121426560  DT.121426571 

    24/63 AceView cDNA sequences (see all 63):

    BM921563 AJ289121 AA311140 BM919793 AJ289111 AJ289112 CR608653 AJ289122 
    BP368048 X79519 AJ289119 BX404845 X79518 CR598515 AJ289113 AJ289118 
    CR611169 NM_030893 AJ289120 X79517 AA354144 BP367982 BX406609 BX447451 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CD1E (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
    SP1:                                            -     -                 -           -     -     -         
    SP2:                                            -     -                 -                       -         
    SP3:                                            -     -                 -                                 
    SP4:                                            -     -     -     -     -           -     -     -         
    SP5:                                            -     -     -     -     -                                 


    ECgene alternative splicing isoforms for CD1E

    Expression
    for CD1E gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CD1E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD1E

    SOURCE GeneReport for Unigene cluster: Hs.249217

    UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812
    Tissue specificity: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias,
    and in various other tissues

        SABiosciences Custom PCR Arrays for CD1E
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD1E
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD1E
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1E
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1E
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1E

    Orthologs
    for CD1E gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD1E gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CD1C1 CD1c molecule 48.74(n)
    33.44(a)    		   425801  NM_001017412.1  NP_001017412.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 26(a)
    		 1 → many
    		 2(189406880-189414378)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX572619.36
    CR339041.46
    (see all 16)    		 --
    		 18(a)
    18(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 25(11071636-11074578)
    25(11314469-11317472)


    ENSEMBL Gene Tree for CD1E (if available)
    TreeFam Gene Tree for CD1E (if available) 

    Paralogs
    for CD1E gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD1E gene
    CD1A2  CD1D2  CD1B2  CD1C2  
    13 SIMAP similar genes for CD1E using alignment to 5 protein entries:     CD1E_HUMAN (see all proteins):
    CDIE    CD1A    CD1b    CD1D    CD1C    CD1B
    MICA    HLA-DRB1    HLA-B    HLA-DRB4    HFE    HLA-A
    HLA-C

    CD1E for paralogs           About GeneDecksing



    Genomic Variants
    for CD1E gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CD1E_HUMAN, P15812
    Polymorphism: Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has
    His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has
    His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has
    His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01


    10/157 NCBI SNPs in CD1E are shown (see all 157)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs357527481,2
    		C,--158321565(+) AAAATA/CAATGT 13 -- us2k17Minor allele frequency- C:0.36NA WA CSA EA 365
    rs1850798941,2
    		--158321574(+) GTAGAC/TATTCT 13 -- us2k10--------
    rs1899173981,2
    		--158321605(+) TTTTTA/TAATCT 13 -- us2k10--------
    rs2016701671,2
    		--158321690(+) TGCAG-/TTTTTT 13 -- us2k10--------
    rs1996257021,2
    		--158321714(+) TTATT-/TTTA  
                TTTAT     		13 -- us2k10--------
    rs1820830771,2
    		--158321769(+) TGTGCA/GCAACG 13 -- us2k10--------
    rs1471021101,2
    		--158321806(+) GTGTCA/GTGTTG 13 -- us2k10--------
    rs1125492401,2
    		--158321816(+) GGTGTG/ACTGCA 13 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1868430281,2
    		--158321847(+) ATTAGA/GTATAT 13 -- us2k10--------
    rs97297371,2
    		C,A,--158322083(+) GTATTT/CCATGG 13 -- us2k12Minor allele frequency- C:0.25NA 4

    HapMap Linkage Disequilibrium report for CD1E (158323254 - 158327343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD1E: --
    Human Gene Mutation Database (HGMD): CD1E

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD1E
    DNA2.0 Custom Variant and Variant Library Synthesis for CD1E

    Disorders / Diseases
    for CD1E gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD1E for disorders           About GeneDecksing

    OMIM gene information: 188411    OMIM disorders: --

    9 diseases for CD1E:    About MalaCards
    guillain-barre syndrome    mycobacterium malmoense    demyelinating polyneuropathy    polyneuropathy
    multiple sclerosis    pulmonary disease    t-cell leukemia    neuropathy
    leukemia

    1 disease from the University of Copenhagen DISEASES database for CD1E:
    Demyelinating polyneuropathy
    Genetic Association Database (GAD): CD1E
    Human Genome Epidemiology (HuGE) Navigator: CD1E (6 documents)

    Export disorders for CD1E gene to outside databases

    Publications
    for CD1E gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD1E gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CD1E)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. (PubMed id 10948205)1, 2, 3 Angenieux C.... de La Salle H. (2000)
    2. A naturally occurring mutation in CD1e impairs lipid antigen presentation. (PubMed id 18325888)1, 2, 9 Tourne S....de la Salle H. (2008)
    3. The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments. (PubMed id 19196239)1, 2 MaArtre B....de la Salle H. (2009)
    4. Control of the intracellular pathway of CD1e. (PubMed id 18208508)1, 2 Maitre B....de la Salle H. (2008)
    5. Assistance of microbial glycolipid antigen processing by CD1e. (PubMed id 16311334)1, 2 de la Salle H....De Libero G. (2005)
    6. Two novel CD1 E alleles identified in black African individuals. (PubMed id 12144626)1, 2 Tamouza R.... Charron D. (2002)
    7. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 4 Jones D.C....Bunce M. (2001)
    8. Identification of two novel human CD1E alleles. (PubMed id 11019917)1, 2 Mirones I.... Martinez-Naves E. (2000)
    9. Polymorphism of human CD1 genes. (PubMed id 10488738)1, 2 Han M.... Robinson M.A. (1999)
    10. Two classes of CD1 genes. (PubMed id 2467814)1, 2 Calabi F.... Milstein C. (1989)

    External Searches for CD1E gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD1E gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 913 HGNC: 1638 AceView: CD1E Ensembl:ENSG00000158488 euGenes: HUgn913
    ECgene: CD1E Kegg: 913 H-InvDB: CD1E

    Other Databases showing CD1E gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD1E gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD1E Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD1E gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD1E gene:
    Search GeneIP for patents involving CD1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CD1E gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD1E (CD1e)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CD1E  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD1E   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD1E  
     OriGene Protein Over-expression Lysate for CD1E   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CD1E   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD1E  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD1E   OriGene Custom Protein Services for CD1E  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD1E
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD1E
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD1E
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1E
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1E
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1E
     GenScript Custom Purified and Recombinant Proteins Services for CD1E GenScript cDNA clones with any tag delivered in your preferred vector for CD1E
     GenScript Custom Assay Services for CD1E GenScript Custom Superior Antibodies Services for CD1E
     GenScript Custom overexpressing Cell Line Services for CD1E CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD1E promoter
     Search Chromatin IP Primers for CD1E
     RT2 qPCR Primer Assay in human, mouse / rat CD1E
     GNC Network for CD1E
     SABiosciences Custom PCR Arrays for CD1E
     Search Tocris compounds for CD1E
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD1E lysates
     Search for Antibodies for CD1E at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CD1E
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CD1E
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1E
     SwitchGear 3'UTR luciferase reporter plasmids for CD1E
     SwitchGear Promoter luciferase reporter plasmids for CD1E
     ThermoFisher Antibody for CD1E
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1E
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CD1E gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4