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Aliases for CD1E Gene

Aliases for CD1E Gene

  • CD1e Molecule 2 3
  • CD1E Antigen, E Polypeptide 2 3
  • CD1e Antigen 2 4
  • HCD1e 3 4
  • R2G1 3 4
  • T-Cell Surface Glycoprotein CD1e, Membrane-Associated 3
  • Differentiation Antigen CD1-Alpha-3 3
  • Leukocyte Differentiation Antigen 3
  • Thymocyte Antigen CD1E 3
  • CD1A 3
  • R2 3

External Ids for CD1E Gene

Previous GeneCards Identifiers for CD1E Gene

  • GC01P156115
  • GC01P154056
  • GC01P155101
  • GC01P155540
  • GC01P155136
  • GC01P156590
  • GC01P129681

Summaries for CD1E Gene

Entrez Gene Summary for CD1E Gene

  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

GeneCards Summary for CD1E Gene

CD1E (CD1e Molecule) is a Protein Coding gene. Diseases associated with CD1E include multifocal motor neuropathy and mycobacterium malmoense. Among its related pathways are Hematopoietic cell lineage. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1C.

UniProtKB/Swiss-Prot for CD1E Gene

  • T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Gene Wiki entry for CD1E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD1E Gene

Genomics for CD1E Gene

Regulatory Elements for CD1E Gene

Genomic Location for CD1E Gene

Start:
158,353,696 bp from pter
End:
158,357,553 bp from pter
Size:
3,858 bases
Orientation:
Plus strand

Genomic View for CD1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD1E Gene

Proteins for CD1E Gene

  • Protein details for CD1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15812-CD1E_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD1e, membrane-associated
    Protein Accession:
    P15812
    Secondary Accessions:
    • B4DZV3
    • E7EP01
    • Q5TDJ9
    • Q5TDK3
    • Q5TDK4
    • Q5TDK5
    • Q5TDK6
    • Q5TDK8
    • Q5TDL1
    • Q712E4
    • Q712E5
    • Q712E6
    • Q712E7
    • Q712E8
    • Q712E9
    • Q712F0
    • Q712F1
    • Q712F2
    • Q712F3
    • Q712F4
    • Q712F5
    • Q96TD0
    • Q96TD1
    • Q9UMM1
    • Q9Y5M3

    Protein attributes for CD1E Gene

    Size:
    388 amino acids
    Molecular mass:
    43626 Da
    Quaternary structure:
    • Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.
    SequenceCaution:
    • Sequence=CAA33100.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD1E Gene

    Alternative splice isoforms for CD1E Gene

neXtProt entry for CD1E Gene

Proteomics data for CD1E Gene at MOPED

Post-translational modifications for CD1E Gene

  • Mono-ubiquitinated.
  • Proteolytically cleaved in late endosomes to yield a soluble form.
  • Ubiquitination at Lys170, Lys179, Lys206, Lys208, Lys210, Lys358, Lys373, and Lys331
  • Glycosylation at Asn47 and Asn84
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD1E Gene

Domains for CD1E Gene

Gene Families for CD1E Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • CD :CD molecules

Suggested Antigen Peptide Sequences for CD1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15812

UniProtKB/Swiss-Prot:

CD1E_HUMAN :
  • P15812
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD1E: view

Function for CD1E Gene

Molecular function for CD1E Gene

GENATLAS Biochemistry: cell differentiation antigen CD1E (see CD1@)
UniProtKB/Swiss-Prot Function: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Gene Ontology (GO) - Molecular Function for CD1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008289 lipid binding --
GO:0030881 beta-2-microglobulin binding IBA --
GO:0030883 endogenous lipid antigen binding IBA --
GO:0030884 exogenous lipid antigen binding IBA --
genes like me logo Genes that share ontologies with CD1E: view

Phenotypes for CD1E Gene

GenomeRNAi human phenotypes for CD1E:
genes like me logo Genes that share phenotypes with CD1E: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD1E Gene

Localization for CD1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD1E Gene

T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.
T-cell surface glycoprotein CD1e, soluble: Lysosome lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD1E Gene COMPARTMENTS Subcellular localization image for CD1E gene
Compartment Confidence
endosome 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CD1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005764 lysosome --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with CD1E: view

Pathways for CD1E Gene

SuperPathways for CD1E Gene

Superpath Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD1E: view

Pathways by source for CD1E Gene

1 KEGG pathway for CD1E Gene

Interacting Proteins for CD1E Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357149%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000357149 P15812-CD1E_HUMAN for CD1E Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CD1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 2467814
GO:0019882 antigen processing and presentation --
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA --
genes like me logo Genes that share ontologies with CD1E: view

Compounds for CD1E Gene

(519) HMDB Compounds for CD1E Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
genes like me logo Genes that share compounds with CD1E: view

Transcripts for CD1E Gene

Unigene Clusters for CD1E Gene

CD1e molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD1E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD1E Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - -
SP11: - - -
SP12:
SP13: -

Relevant External Links for CD1E Gene

GeneLoc Exon Structure for
CD1E
ECgene alternative splicing isoforms for
CD1E

Expression for CD1E Gene

mRNA expression in normal human tissues for CD1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD1E Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (5.9), Esophagus - Mucosa (5.2), and Skin - Sun Exposed (Lower leg) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD1E Gene

SOURCE GeneReport for Unigene cluster for CD1E Gene Hs.249217

mRNA Expression by UniProt/SwissProt for CD1E Gene

P15812-CD1E_HUMAN
Tissue specificity: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
genes like me logo Genes that share expressions with CD1E: view

In Situ Assay Products

Orthologs for CD1E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD1E 35
  • 98.68 (n)
  • 96.84 (a)
CD1E 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD1E 35
  • 77.87 (n)
  • 69.58 (a)
CD1E 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD1E 35
  • 73.23 (n)
  • 66.04 (a)
CD1E 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD1.2 36
  • 24 (a)
ManyToMany
CD1A1 36
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
OneToMany
Species with no ortholog for CD1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD1E Gene

ENSEMBL:
Gene Tree for CD1E (if available)
TreeFam:
Gene Tree for CD1E (if available)

Paralogs for CD1E Gene

Paralogs for CD1E Gene

Selected SIMAP similar genes for CD1E Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD1E: view

Variants for CD1E Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD1E Gene

P15812-CD1E_HUMAN
Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01

Sequence variations from dbSNP and Humsavar for CD1E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs765629 -- 158,357,096(-) TTATA(G/T)TTTCA utr-variant-3-prime
rs858565 -- 158,353,171(+) ATGCT(C/T)TCTTC upstream-variant-2KB
rs1065457 - 158,354,635(+) TATCC(A/G)GATAG reference, missense, intron-variant
rs2873587 - 158,354,623(+) CTTCC(A/G)TAGTT reference, missense, intron-variant
rs3180089 - 158,354,032(+) TCCTG(A/G)GGAAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CD1E Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294
nsv831692 CNV Gain 17160897

Relevant External Links for CD1E Gene

HapMap Linkage Disequilibrium report
CD1E
Human Gene Mutation Database (HGMD)
CD1E

Disorders for CD1E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CD1E Gene including...

Search for CD1E Gene in MalaCards »

(1) University of Copenhagen DISEASES for CD1E Gene

Relevant External Links for CD1E

Genetic Association Database (GAD)
CD1E
Human Genome Epidemiology (HuGE) Navigator
CD1E
genes like me logo Genes that share disorders with CD1E: view

No data available for UniProtKB/Swiss-Prot for CD1E Gene

Publications for CD1E Gene

  1. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. (PMID: 10948205) Angenieux C. … de La Salle H. (J. Biol. Chem. 2000) 2 3 4
  2. A naturally occurring mutation in CD1e impairs lipid antigen presentation. (PMID: 18325888) Tourne S. … de la Salle H. (J. Immunol. 2008) 3 4 23
  3. Two classes of CD1 genes. (PMID: 2467814) Calabi F. … Milstein C. (Eur. J. Immunol. 1989) 3 4
  4. Isolation of CD1 genes: a family of major histocompatibility complex- related differentiation antigens. (PMID: 3097645) Martin L.H. … Milstein C. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Assistance of microbial glycolipid antigen processing by CD1e. (PMID: 16311334) de la Salle H. … De Libero G. (Science 2005) 3 4

Products for CD1E Gene

Sources for CD1E Gene

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