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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD1D Gene

protein-coding GIFtS: 64
GCID: GC01P158149

CD1d molecule

(Previous names: CD1D antigen, d polypeptide, CD1d antigen )

Explore 39 diseases affiliated with
CD1D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD1d Molecule¹ ²		Antigen-Presenting Glycoprotein CD1d²
CD1D Antigen, D Polypeptide¹ ²		Differentiation Antigen CD1-Alpha-3²
CD1d Antigen¹ ³		HMC Class I Antigen-Like Glycoprotein CD1D²
R3G1² ³		T-Cell Surface Glycoprotein CD1d²
CD1A²		Thymocyte Antigen CD1D²
R3²

External Ids:	HGNC: 1637¹	Entrez Gene: 912²	Ensembl: ENSG00000158473⁷	OMIM: 188410⁵	UniProtKB: P15813³

Export aliases for CD1D gene to outside databases

Previous GC identifers: GC01P155941 GC01P153882 GC01P154927 GC01P155366 GC01P154962 GC01P156416 GC01P129508

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD1D:

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related

to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1

proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells.

The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are

thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by

this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD1D_HUMAN, P15813

Function: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on

natural killer T-cells

Gene Wiki entry for CD1D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD1D gene promoter:
AML1a FOXD3 E47 AREB6 PPAR-gamma1 POU2F1 POU2F1a HOXA5 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD1D promoter sequence

Search SABiosciences Chromatin IP Primers for CD1D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD1D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q22-q23

CD1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1D gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P158149: view genomic region (about GC identifiers)

Start:	158,149,737 bp from pter	End:	158,156,217 bp from pter
Size:	6,481 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD1D_HUMAN, P15813 (See protein sequence)

Recommended Name: Antigen-presenting glycoprotein CD1d precursor

Size: 335 amino acids; 37717 Da

Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane.

Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes

Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by

lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to

the cell surface (By similarity)

6/9 PDB 3D structures from and Proteopedia for CD1D (see all 9):

1ZT4 (3D)

2PO6 (3D)

3HUJ (3D)

3SDX (3D)

3TZV (3D)

3U0P (3D)

Secondary accessions: D3DVD5 Q5W0J3 Q9UMM3 Q9Y5M4

Explore the universe of human proteins at neXtProt for CD1D: NX_P15813

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15813

CD1D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001757.1

ENSEMBL proteins:

ENSP00000357153

Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19124746
GO:0005765	lysosomal membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	11315191
GO:0009986	cell surface	IDA	19124746
GO:0010008	endosome membrane	IEA	--

CD1D for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD1D for domains About GeneDecksing

5 InterPro domains/families:

IPR011162 MHC_I/II-like_Ag-recog

IPR013783 Ig-like_fold

IPR003597 Ig_C1-set

IPR007110 Ig-like_dom

IPR011161 MHC_I-like_Ag-recog

Graphical View of Domain Structure for InterPro Entry P15813

ProtoNet protein and cluster: P15813

1 Blocks protein family: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: CD1D_HUMAN, P15813

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD1D_HUMAN, P15813

Function: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on

natural killer T-cells

Genatlas biochemistry entry for CD1D:

cell differentiation antigen CD1D,49kDa,cell surface molecule,B2M associated,identified by monoclonal antibody NOR3.2

expressed on a cortical thymocyte cell line (see CD1@)

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD1D:
		hsa-miR-22 hsa-miR-4311 hsa-miR-1271 hsa-miR-514b-5p hsa-miR-513c hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: CD1D 3' UTR sequence

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD1D
		Search LifeMap BioReagents cell lines for CD1D

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1D

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IC	11315191
GO:0030881	beta-2-microglobulin binding	TAS	14500461
GO:0030882	lipid antigen binding	IDA	19124746
GO:0030884	exogenous lipid antigen binding	IDA	10523605
GO:0042393	histone binding	IPI	--

CD1D for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD1D:

Decreased Hepatitis C virus re

Animal Models:
Mouse knock-outs for CD1D: Cd1d1/Cd1d2^Cd1d1/tm1Crw Cd1d1^tm1.2Aben Cd1d1^tm1Luc Cd1d1^tm1Crw Cd1d1/Cd1d2^Cd1d1/tm1Spb
12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Cd1d1):

behavior/neurological	cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	nervous system	renal/urinary system
respiratory system	skeleton

CD1D for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amoebiasis

Amoebiasis

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for CD1D):

	Hematopoietic cell lineage
	Amoebiasis

CD1D for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD1D

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/11 Interacting proteins for CD1D (P15813³ ENSP00000357153⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
B2M	P61769³, ENSP00000340858⁴	I2D: score=5 STRING: ENSP00000340858
CALR	P27797³, ENSP00000320866⁴	I2D: score=3 STRING: ENSP00000320866
PTPRC	P08575³, ENSP00000356346⁴	I2D: score=3 STRING: ENSP00000356346
CD74	P04233³, ENSP00000009530⁴	I2D: score=2 STRING: ENSP00000009530
P4HTM	Q9NXG6³, ENSP00000341422⁴	I2D: score=1 STRING: ENSP00000341422

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016045	detection of bacterium	TAS	14500461
GO:0019048	virus-host interaction	IEA	--
GO:0034113	heterotypic cell-cell adhesion	TAS	19124746
GO:0042102	positive regulation of T cell proliferation	IDA	19124746
GO:0044419	interspecies interaction between organisms	--	--

CD1D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD1D for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD1D

10/519 HMDB Compounds for CD1D (see all 519) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Dehydrosphinganine	1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)	16105-69-4	--
3-O-Sulfogalactosylceramide (d18:1/12:0)	Sulfatide (d18:1/12:0) (see all 13)	852100-88-0	--
3-O-Sulfogalactosylceramide (d18:1/14:0)	Sulfatide (d18:1/14:0) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/16:0)	Sulfatide (d18:1/16:0) (see all 13)	862509-48-6	--
3-O-Sulfogalactosylceramide (d18:1/18:0)	Sulfatide (d18:1/18:0) (see all 13)	244215-65-4	--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))	Sulfatide (d18:1/18:1(9Z)) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/20:0)	Sulfatide (d18:1/20:0) (see all 13)	265096-81-9	--
3-O-Sulfogalactosylceramide (d18:1/22:0)	Sulfatide (d18:1/22:0) (see all 13)	265096-83-1	--
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))	Sulfatide (d18:1/24:1(15Z)) (see all 13)	151057-28-2	--

1 DrugBank Compound for CD1D About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cis-tetracosenoyl sulfatide	--	--	target	--	10592235

7 Novoseek chemical compound relationships for CD1D gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-galactosylceramide	90	18	19651460 (1), 10692041 (1), 12360465 (1), 15147365 (1) (see all 13)
glycolipid	80.5	23	12730881 (4), 17277112 (2), 10754338 (1), 18460919 (1) (see all 15)
lipid	44.3	26	17372201 (6), 19124746 (2), 19863613 (2), 16982809 (2) (see all 11)
retinoid	19	2	16982809 (1), 17392484 (1)
ceramide	18.1	6	16456021 (2), 14551186 (1)
retinoic acid	11	19	17392484 (6), 16982809 (3), 19651460 (2)
vitamin a	4.47	1	17392484 (1)

Search CenterWatch for drugs/clinical trials and news about CD1D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD1D gene:

NM_001766.3

Unigene Cluster for CD1D:

CD1d molecule

Hs.1799 [show with all ESTs]

Unigene Representative Sequence: NM_001766

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000368171(uc009wsr.1 uc009wst.1 uc001frr.3 uc009wss.3)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1D

Additional cDNA sequence:

AK225996.1 AK310749.1 BC027926.1 J04142.1

6 DOTS entries:

DT.113444 DT.100674898 DT.113445 DT.121337575 DT.100713243 DT.100644124

24/44 AceView cDNA sequences (see all 44):

AI344373 T29620 AI990497 NM_001766 BC027926 AU099295 T08190 AU105006

F01433 CR615787 F02407 BI834737 F05183 BX370654 AW949814 J04142

AA380729 AA974299 AI469028 AA450238 AW956859 AL561022 F06138 AI825555

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD1D (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	^	9a	·	9b
SP1:													-																-
SP2:			-										-
SP3:											-		-
SP4:													-		-
SP5:											-		-		-

ECgene alternative splicing isoforms for CD1D

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD1D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGATTTTA

About this image

CD1D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD1D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD1D

SOURCE GeneReport for Unigene cluster: Hs.1799

UniProtKB/Swiss-Prot: CD1D_HUMAN, P15813

Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including CD1D:

Innate & Adaptive Immune Responses in human mouse rat

Cell Surface Markers in human mouse rat

Antigen Presenting Cells in human mouse rat

T-cell & B-cell Activation in human mouse rat

Hematopoiesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD1D gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GGA.29894⁶	Uncharacterized protein	22(a)	1 → many	16(1371-11718)
lizard (Anolis carolinensis)	Reptilia	--	--	26(a)	1 → many	2(189406880-189414378)
zebrafish (Danio rerio)	Actinopterygii	CR339041.4⁶ BX572619.3⁶ (see all 16)	--	18(a) 18(a) (see all 16)	many ↔ many many ↔ many (see all 16)	25(11314469-11317472) 25(11071636-11074578)

ENSEMBL Gene Tree for CD1D (if available)
TreeFam Gene Tree for CD1D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD1D gene

CD1A² CD1B² CD1C² CD1E²

4 SIMAP similar genes for CD1D using alignment to 1 protein entry: CD1D_HUMAN:

CD1A CD1E CD1C CD1B

CD1D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs859002^1,2	F,	--	158147792(-)	`GTGGAG/AGGCGG`	1	--	us2k¹		3		WA NA EA	358
rs140905351^1,2		--	158147908(+)	`AGTGGA/TTCTCC`	1	--	us2k¹		0	--	--	--	--
rs859003^1,2	C,F,O,H,	--	158148054(-)	`AAGTTT/CAACAG`	1	--	us2k¹		12		NS EA NA WA	920
rs150160860^1,2		--	158148129(+)	`GAGTTA/CTTTAG`	1	--	us2k¹		0	--	--	--	--
rs859004^1,2	C,F,H,	--	158148184(-)	`GAGGAT/CACATC`	1	--	us2k¹		17		NS EA NA WA CSA	798
rs78954064^1,2	F,	--	158148412(+)	`AATTAA/GCACAT`	1	--	us2k¹		1		WA	118
rs859005^1,2	C,F,O,H,	--	158148599(-)	`AAATAT/GTTTAT`	1	--	us2k¹ tfbs³		13		MN NS EA NA WA	1106
rs188623661^1,2		--	158148629(+)	`AAAACA/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs192763950^1,2		--	158148691(+)	`AAAAAA/GTGTCT`	1	--	us2k¹		0	--	--	--	--
rs184982774^1,2		--	158148727(+)	`TATCCA/GTATAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD1D (158149737 - 158156217 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD1D
1 CNV: 84603

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD1D for disorders           About GeneDecksing

OMIM gene information: 188410    OMIM disorders: --

20/39 diseases for CD1D (see all 39):    About MalaCards

guillain-barre syndrome hypersensitivity reaction type ii disease mycobacterium malmoense chronic inflammatory demyelinating polyneuropathy

demyelinating polyneuropathy relapsing polychondritis wegener's granulomatosis primary biliary cirrhosis

polyneuropathy rheumatoid arthritis chronic lymphocytic leukemia multiple sclerosis

herpes simplex lymphocytic leukemia multiple myeloma eczema

hepatitis c hepatitis b encephalomyelitis arthritis

3 diseases from the University of Copenhagen DISEASES database for CD1D:

Heart disease Cancer Diabetes mellitus

7 Novoseek disease relationships for CD1D gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmunity	40.5	1	15100293 (1)
autoimmune diseases	37.5	5	14719188 (1), 19415116 (1), 20477630 (1), 15654963 (1) (see all 5)
rheumatoid arthritis	6.37	2	14719188 (1), 16178791 (1)
multiple sclerosis	4.53	2	10884613 (1), 16178791 (1)
inflammation	1.59	4	19651460 (2), 11927549 (1)
shock	0	3	12952923 (2), 12952910 (1)
tumors	0	9	17071498 (3), 15100293 (1), 16403914 (1), 10450506 (1) (see all 6)

Genetic Association Database (GAD): CD1D
Human Genome Epidemiology (HuGE) Navigator: CD1D (5 documents)

Export disorders for CD1D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD1D gene, integrated from 9 sources (see all 190):
(articles sorted by number of sources associating them with CD1D)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule. (PubMed id 2463622)^{1, 2, 3} Balk S.P.... Terhorst C. (1989)
Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. (PubMed id 11927549)^{1, 2, 9} Kang S.-J. and Cresswell P. (2002)
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. (PubMed id 17581592)^{1, 2, 9} Borg N.A....Rossjohn J. (2007)
Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules. (PubMed id 17475845)^{1, 2} Chen X....Gumperz J.E. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
CD1d ligands: the good, the bad, and the ugly. (PubMed id 16818729)^{1, 2} Brutkiewicz R.R. (2006)
The crystal structure of human CD1d with and without alpha- galactosylceramide. (PubMed id 16007090)^{1, 2} Koch M.... Cerundolo V. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)^{1, 4} Jones D.C....Bunce M. (2001)
Polymorphism of human CD1 genes. (PubMed id 10488738)^{1, 2} Han M.... Robinson M.A. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 912	HGNC: 1637	AceView: CD1D	Ensembl:ENSG00000158473	euGenes: HUgn912
ECgene: CD1D	Kegg: 912	H-InvDB: CD1D

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD1D	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD1D	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CD1D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD1D gene:
Search GeneIP for patents involving CD1D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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