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Aliases & Descriptions for CD1C
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BDCA1 2 | | CD1 2 | | CD1A 2 | | OTTHUMP00000018909 2 | | R7 2 |
| | | Descriptions |
|---|
| CD1C antigen, c polypeptide 1, 2 | | CD1c antigen 1, 2, 3 | | CD1c molecule 2 | | T-cell surface glycoprotein CD1c 2 | | cortical thymocyte antigen CD1C 2 | | differentiation antigen CD1-alpha-3 2 |
|
| | Search outside databases for aliases for CD1C genePrevious GC identifers: GC01P156052 GC01P153993 GC01P155037 GC01P155476 GC01P155072 |
Summaries for CD1C(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CD1C: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq] UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells |
Genomic Location for CD1C
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CD1C gene 
Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q22-q23CD1C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P156526:
(about GC identifiers)
Start:
|
156,526,187 bp from pter |
End:
|
156,531,188 bp from pter |
Size:
|
5,002 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for CD1C
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017 (See
protein sequence)Recommended Name: T-cell surface glycoprotein CD1c precursor Size: 333 amino acids; 37654 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface
Secondary accessions: Q5TDJ7 Q6IAS4 Q9UMM0 Q9UN96REFSEQ proteins: NP_001756.2
ENSEMBL proteins: ENSP00000357151 ENSP00000357152
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CD1C: Assays for CD1C: | Protein
Domains/ Families for CD1C(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P29017
ProtoNet protein and cluster: P29017 1 Blocks protein family: IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017Similarity: Contains 1 Ig-like (immunoglobulin-like) domain | Gene Function for CD1C
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001765
Applied Biosystems Silencer® siRNAs for CD1C
Sigma-Aldrich siRNA and siRNA Panels for CD1C  Sigma-Aldrich shRNA for CD1C  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001765                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001765                                  untagged cDNA clone in CMV expression vector: NM_001765 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001765
UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cellsGenatlas biochemistry entry for CD1C:cell differentiation antigen CD1C,43kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies L161,7C6,PHM3 (see CD1@) | Pathways & Interactions for CD1C
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for CD1C (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for CD1C 
5/19 Interacting proteins for CD1C (ENSP000003571513) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
IEA | -- | | GO:0019882 | antigen processing and presentation |
IEA | -- | About this table
|
Drugs & Compounds for CD1C(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CD1C 2 Novoseek chemical compound relationships for CD1C gene
About this table
|
Transcripts for CD1C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001765
Sigma-Aldrich siRNA and siRNA Panels for CD1C  Sigma-Aldrich shRNA for CD1C  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001765 REFSEQ mRNAs for CD1C gene: NM_001765.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001765               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001765                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001765                                  untagged cDNA clone in CMV expression vector: NM_001765  Additional cDNA sequence: AK226024.1 AK298234.1 AK310577.1 AK310710.1 BC126465.1 BC126467.1 CR457080.1 CR615066.1 M28827.1 X79311.1 7 DOTS entries: DT.211442 DT.121377686 DT.75102006 DT.121377698 DT.92418900 DT.95158096 DT.121377680 24/55 AceView cDNA sequences (see all 55
):CA436720 AV715961 X79311 BU682739 CR615066 AA380406 CB162552 CB161588 NM_001765 AI707712 BQ006118 M28827 AV714702 BP340167 AI673412 AI735359 AA769104 AI290786 BI772670 BX116983 BP368739 BI523941 AW574786 AW405718
highest scoring ESTs for CD1C:M28827 AA002086 AA829831 AI290786 AI302337 AI623784 AI672684 AI961746 AW574786 BE832272 Unigene Cluster for CD1C: CD1c molecule Hs.132448 [show with all ESTs]Unigene Representative Sequence: NM_001765
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CD1C
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | |
| SP1: | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for CD1C
2 Ensembl transcripts including schematic representations: ENST00000368169
ENST00000368170
|
Expression for CD1C
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CD1C expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CD1C
1 / 2 / 3 4 probe-sets matching CD1C gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.132448
Expression variation in blood from EXPOLDB for CD1C UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues |
Orthologs for CD1C
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD1C gene from 2 species
About this table Species with no ortholog for CD1C
ENSEMBL Gene Tree for CD1C | Paralogs for CD1C(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CD1C gene
- CD1A2 CD1D2 CD1B2 CD1E2
|
SNPs/Variants for CD1C(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CD1C (up to first 250kb)
|
Disorders & Mutations for CD1C
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 188340
6 Novoseek disease relationships for CD1C gene
About this table
Genetic Association Database: CD1C Human Genome Epidemiology Navigator: CD1C (2 documents)
|
Medical News for CD1C(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CD1C (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/90 PubMed articles for CD1C gene (see all 90
):- Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)2, 3, 4 Martin L.H.... Milstein C. (1987)
- Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. (PubMed id 10899914)1, 3, 4 Briken V.... Porcelli S.A. (2000)
- CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. (PubMed id 10786796)1, 3, 4 Moody D.B....Porcelli S.A. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)3, 6 Jones D.C....Bunce M. (2001)
- CD1c molecules broadly survey the endocytic system. (PubMed id 10890914)3, 4 Sugita M....Brenner M.B. (2000)
- Polymorphism of human CD1 genes. (PubMed id 10488738)3, 4 Han M.... Robinson M.A. (1999)
- Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. (PubMed id 2701945)3, 4 Aruffo A. and Seed B. (1989)
- Isolation of CD1 genes: a family of major histocompatibility complex- related differentiation antigens. (PubMed id 3097645)3, 4 Martin L.H.... Milstein C. (1986)
|
Search for CD1C
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CD1C
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CD1C
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD1C(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CD1C(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CD1C:

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