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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD1C Gene

protein-coding   GIFtS: 56
GCID: GC01P158259

CD1c Molecule

(Previous names: CD1C antigen, c polypeptide, CD1c antigen)
(Previous symbol: CD1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD1c Molecule1 2     CD1A2
CD11 2     R72
CD1C Antigen, C Polypeptide1 2     Cortical Thymocyte Antigen CD1C2
CD1c Antigen1 3     Differentiation Antigen CD1-Alpha-32
BDCA12     T-Cell Surface Glycoprotein CD1c2

External Ids:    HGNC: 16361   Entrez Gene: 9112   Ensembl: ENSG000001584817   OMIM: 1883405   UniProtKB: P290173   

Export aliases for CD1C gene to outside databases

Previous GC identifers: GC01P156052 GC01P153993 GC01P155037 GC01P155476 GC01P155072 GC01P156526 GC01P129617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD1C Gene:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins
mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The
human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are
thought to differ in their cellular localization and specificity for particular lipid ligands. The protein
encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the
cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their
full-length nature is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD1C Gene: 
CD1C (CD1c molecule) is a protein-coding gene. Diseases associated with CD1C include mycobacterium malmoense, and langerhans-cell histiocytosis. GO annotations related to this gene include lipopeptide binding and glycolipid binding. An important paralog of this gene is CD1A.

UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD1C gene promoter:
         Bach1   AP-1   LCR-F1   Evi-1   MEF-2A   S8   Chx10   aMEF-2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CD1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22-q23

CD1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158259:  view genomic region     (about GC identifiers)

Start:
158,259,563 bp from pter      End:
158,264,564 bp from pter
Size:
5,002 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1c precursor  
Size: 333 amino acids; 37654 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to
intracellular trafficking between the cell membrane and endosomes
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are
replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or
lysosomes, before trafficking back to the cell surface
1 PDB 3D structure from and Proteopedia for CD1C:
3OV6 (3D)    
Secondary accessions: Q5TDJ7 Q6IAS4 Q9UMM0 Q9UN96

Explore the universe of human proteins at neXtProt for CD1C: NX_P29017

Explore proteomics data for CD1C at MOPED 

CD1C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CD1C Protein Expression

REFSEQ proteins: NP_001756.2  
ENSEMBL proteins: 
 ENSP00000357152   ENSP00000408755  

Human Recombinant Protein Products for CD1C: 
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Novus Biologicals CD1C Proteins
Novus Biologicals CD1C Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS2447586
GO:0005887integral to plasma membrane TAS1702817
GO:0010008endosome membrane IEA--

CD1C for ontologies           About GeneDecksing



CD1C Antibody Products: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
C1SET: Immunoglobulin superfamily / C1-set domain containing

5 InterPro protein domains:
 IPR011162 MHC_I/II-like_Ag-recog
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR011161 MHC_I-like_Ag-recog

Graphical View of Domain Structure for InterPro Entry P29017

ProtoNet protein and cluster: P29017

1 Blocks protein domain: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


CD1C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CD1C_HUMAN, P29017
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells

     Genatlas biochemistry entry for CD1C:
cell differentiation antigen CD1C,43kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies
L161,7C6,PHM3 (see CD1@)

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0030881beta-2-microglobulin binding IBA--
GO:0030883endogenous lipid antigen binding IDA--
GO:0030884exogenous lipid antigen binding IDA--
GO:0051861glycolipid binding IDA--
     
CD1C for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CD1C:
 Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CD1C 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD1C

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD1C 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD1C 

miRNA
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Inhib. RNA
Products:
    
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Gene Editing
Products:
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Clone
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1C


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CD1C About                                                                                                See pathways by source

SuperPathContained pathways About
1Hematopoietic cell lineage
Hematopoietic cell lineage

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1         Kegg Pathway  (Kegg details for CD1C):
    Hematopoietic cell lineage


CD1C for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD1C

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002286T cell activation involved in immune response IDA--
GO:0019882antigen processing and presentation ----
GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA--

CD1C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD1C for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD1C

10/519 HMDB Compounds for CD1C (see all 519)    About this table
CompoundSynonyms CAS #PubMed Ids
3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

2 Novoseek inferred chemical compound relationships for CD1C gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glycolipid 71.4 8 9820479 (1), 12391186 (1), 15185366 (1), 15493902 (1) (see all 6)
lipid 53.1 52 11145857 (3), 19374905 (3), 14551186 (3), 10899914 (3) (see all 25)

Search CenterWatch for drugs/clinical trials and news about CD1C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD1C gene: 
NM_001765.2  

Unigene Cluster for CD1C:

CD1c molecule
Hs.132448  [show with all ESTs]
Unigene Representative Sequence: NM_001765
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368170(uc001fru.3 uc021pbl.1) ENST00000443761
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD1C
1 QIAGEN miScript miRNA Assays for microRNA that regulate CD1C:
hsa-miR-550a
SwitchGear 3'UTR luciferase reporter plasmidCD1C 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CD1C
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1C
Clone
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OriGene clones in human, mouse for CD1C (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CD1C (NM_001765)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD1C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1C
Sirion Biotech Customized lentivirus for stable overexpression of CD1C 
                     Customized lentivirus expression plasmids for stable overexpression of CD1C 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CD1C
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD1C
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1C
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1C

Additional mRNA sequence: 

AK226024.1 AK298234.1 AK310577.1 AK310710.1 BC126465.1 BC126467.1 CR457080.1 M28827.1 
X79311.1 

7 DOTS entries:

DT.211442  DT.121377686  DT.75102006  DT.121377698  DT.92418900  DT.95158096  DT.121377680 

24/55 AceView cDNA sequences (see all 55):

CB161588 M28827 CR615066 AV715961 CA436720 BU682739 X79311 AV714702 
CB162552 AA380406 NM_001765 BQ006118 AI707712 BP340167 AI523463 CD709187 
AI673412 BP368739 BP366705 BM804892 T28587 BX401817 AW405718 AI623784 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CD1C    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:        -           -                                 
SP2:                                            -         
SP3:                                                      


ECgene alternative splicing isoforms for CD1C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD1C expression in normal human tissues (normalized intensities)      CD1C embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CD1C Expression
About this image


CD1C expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 4 entries
         Double Negative 3 Thymocytes Thymus
         Peripheral Blood Immature Myeloid Dendritic Cells   
         b cells   
 
 Thymus (Hematopoietic System)    fully expand to see all 3 entries
         Double Negative 3 Thymocytes Thymus
         Thymus   

See CD1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD1C

SOURCE GeneReport for Unigene cluster: Hs.132448

UniProtKB/Swiss-Prot: CD1C_HUMAN, P29017
Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues

    SABiosciences Expression via Pathway-Focused PCR Arrays including CD1C: 
          Cell Surface Markers in human mouse rat
          Antigen Presenting Cells in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1C
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD1C gene from 3/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia CD1C1 CD1c molecule 73.41(n)
67.07(a)
  488609  NM_001128836.1  NP_001122308.1 
chicken
(Gallus gallus)
Aves CD1A16
CD1.26
T-cell surface glycoprotein CD1b precursor
22(a)
20(a)
many ↔ many
many ↔ many
16(2102-4938)
16(5769-8509)
lizard
(Anolis carolinensis)
Reptilia --
--
25(a)
1 → many
2(189404875-189415760)


ENSEMBL Gene Tree for CD1C (if available)
TreeFam Gene Tree for CD1C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CD1C gene
CD1A2  CD1D2  CD1B2  CD1E2  
14 SIMAP similar genes for CD1C using alignment to 2 protein entries:     CD1C_HUMAN (see all proteins):
CDIE    CD1b    CD1B    CD1A    CD1E    CD1D
HLA-DQB1    HLA-DRB1    HLA-DRB4    HLA DRB4    HLA-DRB4*0102    MICA
HFE    HLA-DRB5

CD1C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/187 SNPs in CD1C are shown (see all 187)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1181195001,2
F--158257730(+) CAGGAC/TTGGAG 1 -- us2k11Minor allele frequency- T:0.02EA 120
rs107970061,2
C,F,A,H--158257838(+) TAGGAA/CCATGG 1 -- us2k124Minor allele frequency- C:0.45NS EA NA WA CSA 2508
rs1810379961,2
--158257931(+) AAGATG/TAGCAA 1 -- us2k10--------
rs66899831,2
C,F--158257979(+) TTTGAA/CCTGGG 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs1493233921,2
--158258121(+) AAGTAC/TCATGT 1 -- us2k10--------
rs1442554681,2
C--158258140(+) GTAAAC/TACATA 1 -- us2k10--------
rs172737621,2
C,F,H--158258188(+) ATGGGA/GTTTTC 1 -- us2k1 tfbs310Minor allele frequency- G:0.06NA NS EA WA CSA 676
rs1483018381,2
--158258276(+) TTCAGG/TGCTCA 1 -- us2k10--------
rs1413906351,2
--158258341(+) CACATA/TTGGCC 1 -- us2k10--------
rs1143322211,2
F--158258350(+) CCAACT/CTTTTA 1 -- us2k11Minor allele frequency- C:0.01WA 118

HapMap Linkage Disequilibrium report for CD1C (158259563 - 158264564 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CD1C:    About this table     
Variant IDTypeSubtypePubMed ID
dgv393n71CNV Gain21882294
nsv831692CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CD1C
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 188340    OMIM disorders: --

20/21 diseases for CD1C (see all 21):    About MalaCards
mycobacterium malmoense    langerhans-cell histiocytosis    guillain-barre syndrome    histiocytosis
pertussis    b-cell chronic lymphocytic leukemia    skin disease    mycosis fungoides
sickle cell disease    tuberculosis    periodontal disease    graves' disease
periodontitis    chronic lymphocytic leukemia    psoriasis    t-cell leukemia
hepatitis b    asthma    leukemia    hepatitis


CD1C for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

6 Novoseek inferred disease relationships for CD1C gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmunity 27.6 1 14734115 (1)
infectious disease 24.9 1 18989404 (1)
autoimmune diseases 23.5 5 18989404 (1), 15749918 (1), 12213347 (1)
skin diseases 6.57 1 11564162 (1)
tumors 0 6 18989404 (1), 19428084 (1), 12213347 (1), 14734115 (1)
tuberculosis 0 2 16034117 (2)

Genetic Association Database (GAD): CD1C
Human Genome Epidemiology (HuGE) Navigator: CD1C (4 documents)

Export disorders for CD1C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CD1C gene, integrated from 9 sources (see all 109):
(articles sorted by number of sources associating them with CD1C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)1, 2, 3 Martin L.H.... Milstein C. (1987)
  2. Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. (PubMed id 10899914)1, 2, 9 Briken V.... Porcelli S.A. (2000)
  3. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. (PubMed id 10786796)1, 2, 9 Moody D.B....Porcelli S.A. (2000)
  4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 4 Jones D.C....Bunce M. (2001)
  7. CD1c molecules broadly survey the endocytic system. (PubMed id 10890914)1, 2 Sugita M....Brenner M.B. (2000)
  8. Polymorphism of human CD1 genes. (PubMed id 10488738)1, 2 Han M.... Robinson M.A. (1999)
  9. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. (PubMed id 2701945)1, 2 Aruffo A. and Seed B. (1989)
  10. Isolation of CD1 genes: a family of major histocompatibility complex- related differentiation antigens. (PubMed id 3097645)1, 2 Martin L.H.... Milstein C. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 911 HGNC: 1636 AceView: CD1C Ensembl:ENSG00000158481 euGenes: HUgn911
ECgene: CD1C Kegg: 911 H-InvDB: CD1C

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CD1C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CD1C gene:
Search GeneIP for patents involving CD1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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