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Aliases for CD1B Gene

Aliases for CD1B Gene

  • CD1b Molecule 2 3 5
  • CD1B Antigen, B Polypeptide 2 3
  • CD1b Antigen 2 4
  • Differentiation Antigen CD1-Alpha-3 3
  • Cortical Thymocyte Antigen CD1B 3
  • CD1A 3
  • CD1 3
  • R1 3

External Ids for CD1B Gene

Previous HGNC Symbols for CD1B Gene

  • CD1

Previous GeneCards Identifiers for CD1B Gene

  • GC01M156089
  • GC01M154030
  • GC01M155075
  • GC01M155514
  • GC01M155110
  • GC01M156564
  • GC01M129655

Summaries for CD1B Gene

Entrez Gene Summary for CD1B Gene

  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD1B Gene

CD1B (CD1b Molecule) is a Protein Coding gene. Diseases associated with CD1B include mycobacterium malmoense. Among its related pathways are Immune System and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1C.

UniProtKB/Swiss-Prot for CD1B Gene

  • Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD1B Gene

Genomics for CD1B Gene

Regulatory Elements for CD1B Gene

Promoters for CD1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD1B on UCSC Golden Path with GeneCards custom track

Genomic Location for CD1B Gene

Chromosome:
1
Start:
158,327,950 bp from pter
End:
158,331,531 bp from pter
Size:
3,582 bases
Orientation:
Minus strand

Genomic View for CD1B Gene

Genes around CD1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD1B Gene

Proteins for CD1B Gene

  • Protein details for CD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29016-CD1B_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD1b
    Protein Accession:
    P29016
    Secondary Accessions:
    • Q5TDK9
    • Q5TDL0
    • Q9UMM2

    Protein attributes for CD1B Gene

    Size:
    333 amino acids
    Molecular mass:
    36939 Da
    Quaternary structure:
    • Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C.
    Miscellaneous:
    • During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.
    SequenceCaution:
    • Sequence=CAI10852.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD1B Gene

    Alternative splice isoforms for CD1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD1B Gene

Proteomics data for CD1B Gene at MOPED

Post-translational modifications for CD1B Gene

  • Ubiquitination at Lys 145, Lys 196, and Lys 204
  • Glycosylation at Asn 38, Asn 75, Asn 146, and Asn 258
  • Modification sites at PhosphoSitePlus

Other Protein References for CD1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD1B Gene

Domains & Families for CD1B Gene

Gene Families for CD1B Gene

Suggested Antigen Peptide Sequences for CD1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29016

UniProtKB/Swiss-Prot:

CD1B_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD1B: view

Function for CD1B Gene

Molecular function for CD1B Gene

GENATLAS Biochemistry:
cell differentiation antigen CD1B,45kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies WM-25,4A76,NUT2 (see CD1@)
UniProtKB/Swiss-Prot Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
genes like me logo Genes that share phenotypes with CD1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD1B

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD1B Gene

Localization for CD1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD1B Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269 PubMed:10899914, ECO:0000269 PubMed:10981968, ECO:0000269 PubMed:14716313}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD1B Gene COMPARTMENTS Subcellular localization image for CD1B gene
Compartment Confidence
plasma membrane 5
endosome 4
lysosome 4
vacuole 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with CD1B: view

Pathways & Interactions for CD1B Gene

genes like me logo Genes that share pathways with CD1B: view

Pathways by source for CD1B Gene

Interacting Proteins for CD1B Gene

Gene Ontology (GO) - Biological Process for CD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CD1B: view

No data available for SIGNOR curated interactions for CD1B Gene

Drugs & Compounds for CD1B Gene

(4) Drugs for CD1B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(465) Additional Compounds for CD1B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with CD1B: view

Transcripts for CD1B Gene

mRNA/cDNA for CD1B Gene

Unigene Clusters for CD1B Gene

CD1b molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for CD1B Gene

GeneLoc Exon Structure for
CD1B
ECgene alternative splicing isoforms for
CD1B

Expression for CD1B Gene

mRNA expression in normal human tissues for CD1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD1B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.5), Spleen (x4.9), and Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD1B Gene



SOURCE GeneReport for Unigene cluster for CD1B Gene Hs.1310

mRNA Expression by UniProt/SwissProt for CD1B Gene

P29016-CD1B_HUMAN
Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
genes like me logo Genes that share expression patterns with CD1B: view

Protein tissue co-expression partners for CD1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for CD1B Gene

Orthologs for CD1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD1B 36
  • 99 (a)
OneToOne
CD1B 35
  • 99.3 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia CD1B5 35
  • 81.01 (n)
  • 76.47 (a)
-- 36
  • 74 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
CD1B3 36
  • 76 (a)
OneToMany
CD1B5 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CD1B 36
  • 69 (a)
OneToOne
CD1B 35
  • 75.57 (n)
  • 71.12 (a)
chicken
(Gallus gallus)
Aves CD1.2 36
  • 23 (a)
ManyToMany
CD1A1 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
Species with no ortholog for CD1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD1B Gene

ENSEMBL:
Gene Tree for CD1B (if available)
TreeFam:
Gene Tree for CD1B (if available)

Paralogs for CD1B Gene

Paralogs for CD1B Gene

(5) SIMAP similar genes for CD1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD1B: view

Variants for CD1B Gene

Sequence variations from dbSNP and Humsavar for CD1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs962879 -- 158,330,516(+) GAGAA(C/G)TAAGG intron-variant
rs3176842 -- 158,328,567(-) GACAG(C/T)TCTAC intron-variant
rs3176845 -- 158,328,375(-) CATTC(A/G)TCTAT intron-variant
rs3176847 -- 158,327,905(-) TTTCT(C/G)CTTCT downstream-variant-500B
rs3181082 -- 158,332,703(-) AACCA(A/G)TAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD1B Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294
nsv831692 CNV Gain 17160897

Variation tolerance for CD1B Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD1B Gene

HapMap Linkage Disequilibrium report
CD1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD1B Gene

Disorders for CD1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD1B Gene - From: GeneCards

Disorder Aliases PubMed IDs
mycobacterium malmoense
  • m. malmoense
- elite association - COSMIC cancer census association via MalaCards
Search CD1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD1B

Genetic Association Database (GAD)
CD1B
Human Genome Epidemiology (HuGE) Navigator
CD1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD1B
genes like me logo Genes that share disorders with CD1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD1B Gene

Publications for CD1B Gene

  1. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PMID: 2447586) Martin L.H. … Milstein C. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 67
  2. CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. (PMID: 19808251) Felio K. … Wang C.R. (J. Exp. Med. 2009) 3 23
  3. IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa. (PMID: 18337560) Smed-SAPrensen A. … Sandberg J.K. (Blood 2008) 3 23
  4. pH-dependent interdomain tethers of CD1b regulate its antigen capture. (PMID: 18538591) Relloso M. … Moody D.B. (Immunity 2008) 3 23
  5. Role of lipid trimming and CD1 groove size in cellular antigen presentation. (PMID: 16794581) Cheng T.Y. … Moody D.B. (EMBO J. 2006) 3 23

Products for CD1B Gene

Sources for CD1B Gene

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