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CD1B Gene

protein-coding   GIFtS: 63
GCID: GC01M158297

CD1b Molecule

(Previous names: CD1B antigen, b polypeptide, CD1b antigen)
(Previous symbol: CD1)
  See CD1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD1b Molecule1 2     R12
CD11 2     Cortical Thymocyte Antigen CD1B2
CD1B Antigen, B Polypeptide1 2     Differentiation Antigen CD1-Alpha-32
CD1b Antigen1 3     T-Cell Surface Glycoprotein CD1b2
CD1A2     

External Ids:    HGNC: 16351   Entrez Gene: 9102   Ensembl: ENSG000001584857   OMIM: 1883605   UniProtKB: P290163   

Export aliases for CD1B gene to outside databases

Previous GC identifers: GC01M156089 GC01M154030 GC01M155075 GC01M155514 GC01M155110 GC01M156564 GC01M129655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD1B Gene:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins
mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The
human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are
thought to differ in their cellular localization and specificity for particular lipid ligands. The protein
encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic
tail, and requires vesicular acidification to bind lipid antigens. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD1B Gene:
CD1B (CD1b molecule) is a protein-coding gene. Diseases associated with CD1B include mycobacterium malmoense. GO annotations related to this gene include endogenous lipid antigen binding and beta-2-microglobulin binding. An important paralog of this gene is CD1A.

UniProtKB/Swiss-Prot: CD1B_HUMAN, P29016
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD1B gene promoter:
         CREB   SREBP-1a   SREBP-1c   deltaCREB   LCR-F1   MRF-2   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD1B promoter sequence
   Search Chromatin IP Primers for CD1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

CD1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158297:  view genomic region     (about GC identifiers)

Start:
158,297,740 bp from pter      End:
158,301,321 bp from pter
Size:
3,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD1B_HUMAN, P29016 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1b precursor  
Size: 333 amino acids; 36939 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are
replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or
lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of
bacterial lipid antigens onto CD1B in the lysosome
Sequence caution: Sequence=CAI10852.1; Type=Erroneous gene model prediction;
6 PDB 3D structures from and Proteopedia for CD1B:
1GZP (3D)        1GZQ (3D)        1UQS (3D)        2H26 (3D)        3OV6 (3D)        3T8X (3D)    
Secondary accessions: Q5TDK9 Q5TDL0 Q9UMM2
Alternative splicing: 2 isoforms:  P29016-1   P29016-2   

Explore the universe of human proteins at neXtProt for CD1B: NX_P29016

Explore proteomics data for CD1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys145, Lys196, Lys204
  • Glycosylation2 at Asn38, Asn75, Asn146, Asn258
  • Modification sites at PhosphoSitePlus

  • See CD1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001755.1  
    ENSEMBL proteins: 
     ENSP00000395161   ENSP00000357150  

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CD1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5 InterPro protein domains:
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry P29016

    ProtoNet protein and cluster: P29016

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: CD1B_HUMAN, P29016
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with CD1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD1B_HUMAN, P29016
    Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
    to T-cell receptors on natural killer T-cells

         Genatlas biochemistry entry for CD1B:
    cell differentiation antigen CD1B,45kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies
    WM-25,4A76,NUT2 (see CD1@)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12118248
    GO:0030881beta-2-microglobulin binding IBA--
    GO:0030883endogenous lipid antigen binding IBA--
    GO:0030884exogenous lipid antigen binding IBA--
    GO:0071723lipopeptide binding IBA--
         
    Find genes that share ontologies with CD1B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD1B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD1B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD1B_HUMAN, P29016: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane.
    Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell
    surface lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane IBA--
    GO:0010008endosome membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CD1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD1B About    
    See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage


    Find genes that share SuperPaths with CD1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD1B):
        Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Array including CD1B: 
              Antigen Presenting Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD1B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD1B (P290161, 2, 3 ENSP000003571504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617691, 2, 3, ENSP000003408584EBI-1033762,EBI-714718 MINT-24761 I2D: score=4 STRING: ENSP00000340858
    PSAPP076023, ENSP000003783944I2D: score=1 STRING: ENSP00000378394
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA--

    Find genes that share ontologies with CD1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD1B

    Selected HMDB Compounds for CD1B (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    4 Novoseek inferred chemical compound relationships for CD1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycolipid 75.8 6 14530337 (1), 11208113 (1), 18951873 (1), 9749821 (1) (see all 6)
    lipid 56.8 30 11208113 (5), 16445682 (3), 14530337 (2), 14716313 (2) (see all 19)
    rifampicin 30.9 8 9749821 (5), 9517931 (2), 11233801 (1)
    phosphatidylcholine 12.5 1 14551186 (1)



    Find genes that share compounds with CD1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD1B gene: 
    NM_001764.2  

    Unigene Cluster for CD1B:

    CD1b molecule
    Hs.1310  [show with all ESTs]
    Unigene Representative Sequence: AK310617
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451207 ENST00000368168(uc001frx.3 uc001frw.3 uc010pic.1)

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    Additional mRNA sequence: 

    AK303329.1 AK303330.1 AK310617.1 BC069481.1 BC074747.2 BC104216.1 BC104217.1 M28826.1 

    6 DOTS entries:

    DT.92037228  DT.100743997  DT.100847363  DT.121417044  DT.121417042  DT.95328694 

    22 AceView cDNA sequences:

    AA311900 BP368599 CR601779 BC069481 BC074747 M28826 NM_001764 AW083073 
    CD687240 BX094495 BX457459 AW664772 AW027713 AI827808 AW104324 AW028156 
    AA927946 AI336342 T28176 BP367409 AA983871 BX437125 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CD1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:        -                                             
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for CD1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD1B Expression
    About this image


    CD1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 3 Thymocytes Thymus
    CD1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1310

    UniProtKB/Swiss-Prot: CD1B_HUMAN, P29016
    Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including CD1B: 
              Antigen Presenting Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD1B gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CD1B1 CD1b molecule 75.57(n)
    71.12(a)
      100174779  NM_001130830.1  NP_001124302.1 
    chicken
    (Gallus gallus)
    Aves CD1A16
    CD1.26
    Gallus gallus CD1b molecule (CD1B), mRNA.
    25(a)
    23(a)
    many ↔ many
    many ↔ many
    16(2102-4938)
    16(5769-8509)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    2(189404875-189415760)


    ENSEMBL Gene Tree for CD1B (if available)
    TreeFam Gene Tree for CD1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD1B gene
    CD1A2  CD1D2  CD1C2  CD1E2  
    5 SIMAP similar genes for CD1B using alignment to 2 protein entries:     CD1B_HUMAN (see all proteins):
    CD1b    CD1C    CD1E    CD1A    CD1D

    Find genes that share paralogs with CD1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD1B (see all 185)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442373711,2
    --158297252(+) AGATGA/TGGAGA 1 -- ds50010--------
    rs1928376721,2
    --158297397(+) CAGAGA/TTCTAC 1 -- ds50010--------
    rs1841968171,2
    --158297469(+) TCCAAC/TGCTGT 1 -- ds50010--------
    rs1451873061,2
    --158297513(+) CTTTTA/CTTATA 1 -- ds50010--------
    rs1491274101,2
    --158297514(+) TTTTAC/TTATAG 1 -- ds50010--------
    rs1890715221,2
    --158297620(+) AGGCTC/TTGCAT 1 -- ds50010--------
    rs31768471,2
    C,F,H--158297695(-) TTTCTG/CCTTCT 1 -- ds50018Minor allele frequency- C:0.04NA NS EA WA CSA 582
    rs1923161031,2
    --158297725(+) GAAGCC/GAAAGG 1 -- ds50010--------
    rs1848544671,2
    --158297775(+) TTGAGA/TCACAT 1 -- ut310--------
    rs115833901,2
    C,F,H--158297864(+) AAGTAC/ATTTTT 1 -- ut3119Minor allele frequency- A:0.04NS EA NA 2424

    HapMap Linkage Disequilibrium report for CD1B (158297740 - 158301321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv393n71CNV Gain21882294
    nsv831692CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CD1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188360    OMIM disorders: --

    1 disease for CD1B:    
    About MalaCards
    mycobacterium malmoense

    2 diseases from the University of Copenhagen DISEASES database for CD1B:
    Tuberculosis     Leprosy

    Find genes that share disorders with CD1B           About GenesLikeMe

    1 Novoseek inferred disease relationship for CD1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberculosis 42.9 7 19808251 (1), 9749821 (1), 14716313 (1), 16034117 (1) (see all 6)

    Genetic Association Database (GAD): CD1B
    Human Genome Epidemiology (HuGE) Navigator: CD1B (5 documents)

    Export disorders for CD1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD1B gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with CD1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)1, 2, 3 Martin L.H.... Milstein C. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. Saposin C is required for lipid presentation by human CD1b. (PubMed id 14716313)1, 2, 9 Winau F.... Schaible U.E. (Nat. Immunol. 2004)
    3. Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. (PubMed id 10899914)1, 2, 9 Briken V.... Porcelli S.A. (J. Exp. Med. 2000)
    4. Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. (PubMed id 16874306)1, 2, 9 Garcia-Alles L.F.... Mourey L. (EMBO J. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The crystal structure of human CD1b with a bound bacterial glycolipid. (PubMed id 14764708)1, 2 Batuwangala T.... Jones E.Y. (J. Immunol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. (PubMed id 12118248)1, 2 Gadola S.D....Cerundolo V. (Nat. Immunol. 2002)
    9. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 4 Jones D.C....Bunce M. (Tissue Antigens 2001)
    10. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. (PubMed id 2701945)1, 2 Aruffo A. and Seed B. (J. Immunol. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 910 HGNC: 1635 AceView: CD1B Ensembl:ENSG00000158485 euGenes: HUgn910
    ECgene: CD1B Kegg: 910 H-InvDB: CD1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CD1B gene:
    Search GeneIP for patents involving CD1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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