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Aliases & Descriptions for CD1A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD1 2 | | FCB6 2 | | HTA1 2 | | OTTHUMP00000018907 2 | | R4 2 | | T6 2 |
| | | Descriptions |
|---|
| CD1A antigen, a polypeptide 1, 2 | | CD1a antigen 1, 2, 3 | | CD1a molecule 2 | | T-cell surface antigen T6/Leu-6 2, 3 | | T-cell surface glycoprotein CD1a 2 | | cluster of differentiation 1 A 2 | | cortical thymocyte antigen CD1A 2 | | differentiation antigen CD1-alpha-3 2 | | epidermal dendritic cell marker CD1a 2 | | hTa1 thymocyte antigen 2, 3 |
|
| | Search outside databases for aliases for CD1A genePrevious GC identifers: GC01P156016 GC01P153956 GC01P154952 GC01P155440 GC01P155038 |
Summaries for CD1A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CD1A: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cellsGene Wiki entry for CD1A |
Genomic Location for CD1A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CD1A gene 
Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q22-q23CD1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P156490:
(about GC identifiers)
Start:
|
156,490,551 bp from pter |
End:
|
156,494,683 bp from pter |
Size:
|
4,133 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for CD1A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126 (See
protein sequence)Recommended Name: T-cell surface glycoprotein CD1a precursor Size: 327 amino acids; 37172 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface
PDB structure from and Proteopedia :1ONQ (3D)
 1XZ0 (3D)
 
Secondary accessions: Q13962 Q9UMM4 Q9Y5M5REFSEQ proteins: NP_001754.2
ENSEMBL proteins: ENSP00000289429
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CD1A: Assays for CD1A: | Protein
Domains/ Families for CD1A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P06126
ProtoNet protein and cluster: P06126 1 Blocks protein family: IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126Similarity: Contains 1 Ig-like (immunoglobulin-like) domain | Gene Function for CD1A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001763
Applied Biosystems Silencer® siRNAs for CD1A
Sigma-Aldrich siRNA and siRNA Panels for CD1A  Sigma-Aldrich shRNA for CD1A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001763                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001763                                  untagged cDNA clones in CMV expression vector (see all 2): BC031645 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001763
UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cellsGenatlas biochemistry entry for CD1A:cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies NA1/34,T6,VIT6,Leu6 (see CD1@) | Pathways & Interactions for CD1A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for CD1A (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for CD1A 
5/69 Interacting proteins for CD1A (ENSP000002894293) via UniProtKB, MINT, and/or STRING (see all 69
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for CD1A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CD1A 2 Novoseek chemical compound relationships for CD1A gene
About this table
|
Transcripts for CD1A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001763
Sigma-Aldrich siRNA and siRNA Panels for CD1A  Sigma-Aldrich shRNA for CD1A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001763 REFSEQ mRNAs for CD1A gene: NM_001763.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001763               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001763                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001763                                  untagged cDNA clones in CMV expression vector (see all 2): BC031645  Additional cDNA sequence: AK312945.1 BC031645.1 CR603267.1 M27735.1 M28825.1 X04450.1 8 DOTS entries: DT.100776245 DT.121377677 DT.121377701 DT.100644955 DT.111387 DT.121377691 DT.92416233 DT.121377683 24/30 AceView cDNA sequences (see all 30
):AA310607 L44433 BG679322 X79308 CA432941 BX281603 CR603267 AA354298 AI581337 AW949640 M28825 BI828464 AW303389 BX414919 AI240210 X04450 M27735 BV202113 NM_001763 BC031645 AA310389 AA354975 AA731869 BX457084
highest scoring ESTs for CD1A:M28825 AA310607 AA713783 AA731869 AA916250 AI240210 AI581337 AW303389 AW949640 AW949641 Unigene Cluster for CD1A: CD1a molecule Hs.1309 [show with all ESTs]Unigene Representative Sequence: NM_001763
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000289429
|
Expression for CD1A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CD1A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CD1A
1 / 2 / 3 3 probe-sets matching CD1A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTCTCAATAA
SOURCE GeneReport for Unigene cluster: Hs.1309
Expression variation in blood from EXPOLDB for CD1A UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues |
Orthologs for CD1A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD1A gene from 3 species
About this table Species with no ortholog for CD1A
ENSEMBL Gene Tree for CD1A | Paralogs for CD1A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CD1A gene
- CD1D2 CD1B2 CD1C2 CD1E2
|
SNPs/Variants for CD1A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CD1A (up to first 250kb)
|
Disorders & Mutations for CD1A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 188370
10/15 Novoseek disease relationships for CD1A gene (see all 15
)
About this table
Human Gene Mutation Database: CD1A Genetic Association Database: CD1A Human Genome Epidemiology Navigator: CD1A (5 documents)
|
Medical News for CD1A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CD1A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/172 PubMed articles for CD1A gene (see all 172
):- Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. (PubMed id 2784820)2, 3, 4 Longley J....Edelson R. (1989)
- Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)2, 3, 4 Martin L.H.... Milstein C. (1987)
- CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 3, 6 Jones D.C....Bunce M. (2001)
- Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. (PubMed id 18178838)3, 4 Sloma I.... Gelin C. (2008)
- CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. (PubMed id 16272286)3, 4 Vincent M.S....Brenner M.B. (2005)
- Molecular mechanism of lipopeptide presentation by CD1a. (PubMed id 15723809)3, 4 Zajonc D.M....Wilson I.A. (2005)
- Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. (PubMed id 12833155)3, 4 Zajonc D.M.... Wilson I.A. (2003)
- Polymorphism of human CD1 genes. (PubMed id 10488738)3, 4 Han M.... Robinson M.A. (1999)
- Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. (PubMed id 2701945)3, 4 Aruffo A. and Seed B. (1989)
- A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. (PubMed id 3093894)3, 4 Calabi F. and Milstein C. (1986)
|
Search for CD1A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CD1A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CD1A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD1A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CD1A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CD1A:

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Incremental update: 13 Oct 2009
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