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CD1A Gene(Protein Coding)

CD1a Molecule

GCID:
GC01P158255
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CD1A Gene

Aliases for CD1A Gene

  • CD1a Molecule 2 3 5
  • T-Cell Surface Antigen T6/Leu-6 3 4
  • CD1A Antigen, A Polypeptide 2 3
  • HTa1 Thymocyte Antigen 3 4
  • CD1a Antigen 2 4
  • Epidermal Dendritic Cell Marker CD1a 3
  • Differentiation Antigen CD1-Alpha-3 3
  • T-Cell Surface Glycoprotein CD1a 3
  • Cortical Thymocyte Antigen CD1A 3
  • Cluster Of Differentiation 1 A 3
  • FCB6 3
  • HTA1 3
  • CD1 3
  • R4 3
  • T6 3

External Ids for CD1A Gene

Previous HGNC Symbols for CD1A Gene

  • CD1

Previous GeneCards Identifiers for CD1A Gene

  • GC01P156016
  • GC01P153956
  • GC01P154952
  • GC01P155440
  • GC01P155038
  • GC01P156490
  • GC01P158224
  • GC01P129582

Summaries for CD1A Gene

Entrez Gene Summary for CD1A Gene

  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for CD1A Gene

CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Histiocytosis and Cyclosporiasis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1B.

UniProtKB/Swiss-Prot for CD1A Gene

  • Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Wiki entry for CD1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD1A Gene

Genomics for CD1A Gene

Products:

  1. Regulatory Element

Regulatory Elements for CD1A Gene

Enhancers for CD1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G158324 1.1 FANTOM5 Ensembl dbSUPER 10.4 +76.4 76372 0.6 IKZF1 JUNB RELB IKZF2 TBX21 CD1C CD1A CD1B GC01P158292 GC01P158293
GH01G158273 0.6 dbSUPER 12 +26.3 26321 2.1 MTA2 NR2F1 IKZF1 GATAD2B MLLT1 TBX21 CD1A CD1E HMGN1P5 GC01P158286
GH01G158274 0.6 dbSUPER 12 +26.3 26321 2.1 MTA2 NR2F1 IKZF1 GATAD2B MLLT1 TBX21 CD1A CD1E HMGN1P5 GC01P158286
GH01G158271 0.6 dbSUPER 12 +25.4 25433 4.1 GATA3 JUND MTA2 NR2F1 IKZF1 GATAD2B MLLT1 TBX21 CD1A CD1E HMGN1P5 GC01P158286
GH01G158154 0.7 Ensembl 10.2 -94.0 -94029 0.6 SCRT1 TEAD4 JUNB ZNF83 EED IKZF1 SCRT2 ETV6 ZNF24 IKZF2 CD1D ELL2P1 CD1A CD1C LINC01704
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD1A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD1A gene promoter:

Genomic Location for CD1A Gene

Chromosome:
1
Start:
158,248,329 bp from pter
End:
158,258,269 bp from pter
Size:
9,941 bases
Orientation:
Plus strand

Genomic View for CD1A Gene

Genes around CD1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD1A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD1A Gene

Proteins for CD1A Gene

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  2. Protein
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  • Protein details for CD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06126-CD1A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD1a
    Protein Accession:
    P06126
    Secondary Accessions:
    • D3DVD7
    • Q13962
    • Q5TDJ8
    • Q9UMM4
    • Q9Y5M5

    Protein attributes for CD1A Gene

    Size:
    327 amino acids
    Molecular mass:
    37077 Da
    Quaternary structure:
    • Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.
    Miscellaneous:
    • During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

    Three dimensional structures from OCA and Proteopedia for CD1A Gene

neXtProt entry for CD1A Gene

Protein Expression for CD1A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD1A Gene

  • Ubiquitination at Lys163 and posLast=195195
  • Glycosylation at Asn37, posLast=6060, posLast=7474, and Asn145
  • Modification sites at PhosphoSitePlus

Other Protein References for CD1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD1A Gene

Domains & Families for CD1A Gene

Gene Families for CD1A Gene

HGNC:

Protein Domains for CD1A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD1A: view

No data available for UniProtKB/Swiss-Prot for CD1A Gene

Function for CD1A Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CD1A Gene

GENATLAS Biochemistry:
cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)
UniProtKB/Swiss-Prot Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Ontology (GO) - Molecular Function for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12833155
GO:0030881 beta-2-microglobulin binding IBA --
GO:0030883 endogenous lipid antigen binding IBA --
GO:0030884 exogenous lipid antigen binding IBA --
GO:0071723 lipopeptide binding IBA --
genes like me logo Genes that share ontologies with CD1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD1A Gene

Localization for CD1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD1A Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269 PubMed:11231314, ECO:0000269 PubMed:18178838}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD1A gene
Compartment Confidence
plasma membrane 5
extracellular 3
endosome 3
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2447586
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD1A: view

Pathways & Interactions for CD1A Gene

genes like me logo Genes that share pathways with CD1A: view

Pathways by source for CD1A Gene

2 KEGG pathways for CD1A Gene
1 R&D Systems pathway for CD1A Gene

Interacting Proteins for CD1A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000289429%0d%0a9606.ENSP00000300692%0d%0a9606.ENSP00000431445%0d%0a9606.ENSP00000354566%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000377370%0d%0a
Selected Interacting proteins: P06126-CD1A_HUMAN ENSP00000289429 for CD1A Gene via IID UniProtKB STRING

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
B2M

Gene Ontology (GO) - Biological Process for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response NAS 2447586
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD1A: view

No data available for SIGNOR curated interactions for CD1A Gene

Drugs & Compounds for CD1A Gene

Products:

  1. Drug

(5) Drugs for CD1A Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target, inhibitor 0
Sphingosine Experimental Pharma 0
antithymocyte globulin Pharma binder 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Full agonist, Agonist 0

(464) Additional Compounds for CD1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
 16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
 244215-65-4
genes like me logo Genes that share compounds with CD1A: view

Transcripts for CD1A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CD1A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD1A Gene

CD1a molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD1A Gene

No ASD Table

Relevant External Links for CD1A Gene

GeneLoc Exon Structure for
CD1A
ECgene alternative splicing isoforms for
CD1A

Expression for CD1A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD1A Gene

mRNA expression in normal human tissues for CD1A Gene
mRNA expression by BioGPS for CD1A GenemRNA expression by GTEx for CD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD1A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x17.2), Skin - Sun Exposed (Lower leg) (x16.4), and Esophagus - Mucosa (x5.2).

Protein differential expression in normal tissues from HIPED for CD1A Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD1A Gene



Protein tissue co-expression partners for CD1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD1A Gene:

CD1A

SOURCE GeneReport for Unigene cluster for CD1A Gene:

Hs.1309

mRNA Expression by UniProt/SwissProt for CD1A Gene:

P06126-CD1A_HUMAN
Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

Evidence on tissue expression from TISSUES for CD1A Gene

  • Blood(4.5)
  • Skin(2.3)
  • Heart(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CD1A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD1A Gene

Orthologs for CD1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD1A 34 35
  • 98.31 (n)
cow
(Bos Taurus)
 Mammalia LOC515418 34
  • 73.68 (n)
CD1A 35 35
  • 57 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia CD1A6 34 35
  • 72.58 (n)
-- 35
  • 69 (a)
 OneToMany
CD1A8 35
  • 57 (a)
 OneToMany
-- 35
  • 56 (a)
 OneToMany
-- 35
  • 41 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CD1.2 35
  • 23 (a)
 ManyToMany
CD1A1 35
  • 23 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 25 (a)
 OneToMany
Species where no ortholog for CD1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD1A Gene

ENSEMBL:
Gene Tree for CD1A (if available)
TreeFam:
Gene Tree for CD1A (if available)

Paralogs for CD1A Gene

Paralogs for CD1A Gene

(6) SIMAP similar genes for CD1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD1A: view

Variants for CD1A Gene

Sequence variations from dbSNP and Humsavar for CD1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000052954 -- 158,256,688(+) AAAAA(A/G)AGAGA intron-variant
rs1000082017 -- 158,256,438(+) CTGAG(G/T)CTGGA intron-variant
rs1000356398 -- 158,250,727(+) ATTTG(C/T)GTGTG intron-variant
rs1000700659 -- 158,246,652(+) TAAAA(C/T)ATAAA upstream-variant-2KB
rs1000960106 -- 158,252,051(+) GTCTC(A/G)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD1A Gene

Variant ID Type Subtype PubMed ID
nsv508626 CNV deletion 20534489
nsv515666 CNV loss 19592680
nsv831692 CNV gain 17160897
nsv999542 CNV loss 25217958

Variation tolerance for CD1A Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD1A Gene

Human Gene Mutation Database (HGMD)
CD1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD1A Gene

Disorders for CD1A Gene

MalaCards: The human disease database

(21) MalaCards diseases for CD1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
histiocytosis
  • chronic histiocytosis x
cyclosporiasis
  • cyclospora infection
myofibroma
  • lipoleiomyoma
langerhans cell sarcoma
  • malignant langerhans cell sarcoma
mycobacterium malmoense
  • m. malmoense
- elite association - COSMIC cancer census association via MalaCards
Search CD1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD1A

Genetic Association Database (GAD)
CD1A
Human Genome Epidemiology (HuGE) Navigator
CD1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD1A
genes like me logo Genes that share disorders with CD1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD1A Gene

Publications for CD1A Gene

  1. Susceptibility to Guillain-BarrAc syndrome is not associated with CD1A and CD1E gene polymorphisms. (PMID: 18838176) Kuijf M.L. … Jacobs B.C. (J. Neuroimmunol. 2008) 3 22 46 64
  2. Polymorphisms of CD1 genes in chronic dysimmune neuropathies. (PMID: 17428545) De Angelis M.V. … Uncini A. (J. Neuroimmunol. 2007) 3 22 46 64
  3. Susceptibility to Guillain-BarrAc syndrome is associated to polymorphisms of CD1 genes. (PMID: 16820217) Caporale C.M. … Uncini A. (J. Neuroimmunol. 2006) 3 22 46 64
  4. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PMID: 11580851) Jones D.C. … Bunce M. (Tissue Antigens 2001) 3 22 46 64
  5. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. (PMID: 2784820) Longley J. … Edelson R. (J. Invest. Dermatol. 1989) 2 3 4 64

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