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CD1A Gene

protein-coding   GIFtS: 59

GC01P156490
CD1a molecule
(Previous names: CD1A antigen, a polypeptide, CD1a antigen )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CD1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CD1 2
FCB6 2
HTA1 2
OTTHUMP00000018907 2
R4 2
T6 2
Descriptions
CD1A antigen, a polypeptide 1, 2
CD1a antigen 1, 2, 3
CD1a molecule 2
T-cell surface antigen T6/Leu-6 2, 3
T-cell surface glycoprotein CD1a 2
cluster of differentiation 1 A 2
cortical thymocyte antigen CD1A 2
differentiation antigen CD1-alpha-3 2
epidermal dendritic cell marker CD1a 2
hTa1 thymocyte antigen 2, 3
External Ids
HGNC: 16341
Entrez Gene: 9092
UniProtKB: P061263
Ensembl: ENSG000001584777
Search outside databases for aliases for CD1A gene

Previous GC identifers: GC01P156016 GC01P153956 GC01P154952 GC01P155440 GC01P155038

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CD1A:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally
related to the major histocompatibility complex (MHC) proteins and form heterodimers with
beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid
antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes
organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their
cellular localization and specificity for particular lipid ligands. The protein encoded by this
gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system.
Alternatively spliced transcript variants have been observed, but their biological validity has
not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and
presents them to T-cell receptors on natural killer T-cells

Gene Wiki entry for CD1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CD1A gene  

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22-q23

CD1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156490:     (about GC identifiers)

Start:
156,490,551 bp from pter
End:
156,494,683 bp from pter
Size:
4,133 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1a precursor  
Size: 327 amino acids; 37172 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to
cell surface lipid rafts
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids
that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass
through endosomes, before trafficking back to the cell surface
PDB structure from and Proteopedia :
1ONQ (3D)    1XZ0 (3D)    
Secondary accessions: Q13962 Q9UMM4 Q9Y5M5

REFSEQ proteins: NP_001754.2  

ENSEMBL proteins: 
ENSP00000289429 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (CD1, CD1a)
Human Recombinant Proteins from Abnova (CD1A)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005768 endosome IEA--
GO:0005886 plasma membrane IEA--
GO:0005887 integral to plasma membrane NAS2447586
GO:0010008 endosome membrane IEA--
GO:0042612 MHC class I protein complex IEA--
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Antibodies for CD1A: 
Invitrogen Antibodies for CD1A
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CD1A
Browse R&D Systems for Antibodies
Antibodies from Abcam (CD1, CD1a), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CD1A)
Novus Biologicals Antibodies for CD1A

Assays for CD1A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like
 IPR011161 MHC_I-like_Ag-recog
 IPR001039 MHC_I_a_a1/a2


   GeneDecks  CD1A for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P06126

ProtoNet protein and cluster: P06126

1 Blocks protein family: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CD1A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CD1A)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001763

              Applied Biosystems Silencer® siRNAs for CD1A

              Sigma-Aldrich siRNA and siRNA Panels for CD1A  
                     Sigma-Aldrich shRNA for CD1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001763
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001763
                                 untagged cDNA clones in CMV expression vector (see all 2): BC031645 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001763

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and
presents them to T-cell receptors on natural killer T-cells

Genatlas biochemistry entry for CD1A:
cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by
monoclonal antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Invitrogen iPath™ Online BioAtlas - Pathways for CD1A (Maps provided by GeneGo):
 Lectin Induced complement pathway
 Classic complement pathway

   GeneDecks  CD1A for the pathways selected above  
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for  CD1A  (Your Favorite Gene powered by Ingenuity) 
 Lipid Antigen Presentation by CD1
 Dendritic Cell Maturation

   GeneDecks  CD1A for the pathways selected above  
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1 Kegg Pathway  (Kegg details for CD1A):
 hsa04640 Hematopoietic cell lineage

   GeneDecks  CD1A for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  CD1A 


5/69 Interacting proteins for CD1A (ENSP000002894293) via UniProtKB, MINT, and/or STRING (see all 69 )
InteractantInteraction Details
GeneCardExternal ID(s)
B2MENSP000003408583STRING (score=.972)
CD9ENSP000000091803STRING (score=.941)
HOXA2ENSP000002227183STRING (score=.929)
HOXB2ENSP000003317413STRING (score=.926)
CD209ENSP000003154773STRING (score=.913)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006955 immune response NAS2447586
GO:0019882 antigen processing and presentation IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD1A
2 Novoseek chemical compound relationships for CD1A gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
glycolipid 76.23 8 12391186 (1), 10352272 (1), 17428545 (1), 11035089 (1) (see all 8)
lipid 47.36 41 17593658 (4), 10487835 (3), 9987600 (3), 12492810 (2) (see all 28)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (CD1A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (CD1A)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001763

              Sigma-Aldrich siRNA and siRNA Panels for CD1A  
                     Sigma-Aldrich shRNA for CD1A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001763  

REFSEQ mRNAs for CD1A gene: 

NM_001763.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001763  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001763
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001763
                                 untagged cDNA clones in CMV expression vector (see all 2): BC031645 

Additional cDNA sequence: 

AK312945.1 BC031645.1 CR603267.1 M27735.1 M28825.1 X04450.1 

8 DOTS entries:

DT.100776245  DT.121377677  DT.121377701  DT.100644955  DT.111387  DT.121377691  DT.92416233  DT.121377683 

24/30 AceView cDNA sequences (see all 30 ):

AA310607 L44433 BG679322 X79308 CA432941 BX281603 CR603267 AA354298 
AI581337 AW949640 M28825 BI828464 AW303389 BX414919 AI240210 X04450 
M27735 BV202113 NM_001763 BC031645 AA310389 AA354975 AA731869 BX457084 

highest scoring ESTs for CD1A:

M28825 AA310607 AA713783 AA731869 AA916250 AI240210 AI581337 AW303389 AW949640 AW949641 

Unigene Cluster for CD1A:

CD1a molecule
Hs.1309  [show with all ESTs]
Unigene Representative Sequence: NM_001763


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000289429  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CD1A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CD1A

1 / 2 / 3

3 probe-sets matching CD1A gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
34926_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M28825 1.00 1.00 1.00 1

210325_at2, 3 U133-A 1 1.00 1.00 -- -- M28825 1.00 1.00 1.00 1

210325_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  CD1A for binary patterns associated with the probe-sets selected above  
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About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTCTCAATAA

SOURCE GeneReport for Unigene cluster: Hs.1309

Expression variation in blood from EXPOLDB for CD1A

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells,
on certain T-cell leukemias, and in various other tissues

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for CD1A gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CD1A61   -- CD1a6 protein 72.36(n)
59.63(a)
488608  XM_545725.2  XP_545725.2 
chimpanzee
(Pan troglodytes)
CD1A1   -- CD1a molecule 98.37(n)
96.64(a)
457418  XM_001169121.1  XP_001169121.1 
cow
(Bos taurus)
LOC7810111   -- hypothetical protein LOC781011 74.82(n)
62.23(a)
781011  XM_001249324.1  XP_001249325.1 
About this table        Species with no ortholog for CD1A

ENSEMBL Gene Tree for CD1A
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for CD1A gene
CD1D2  CD1B2  CD1C2  CD1E2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/67 NCBI SNPs in CD1A are shown (see all 67 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs3663161,2
C,F,H,O156490906(+) ATGAGA/GGACTG 1 -- ut5117Minor allele frequency- N:0.00EA NA EU WA 2622
rs22697151,2
C,F,H,O156491643(+) CTGTGC/GCCCTG 1 C/W mis1 ese312Minor allele frequency- G:0.26EA NA EU WA 2440
rs3892931,2
A,C,F,H156495016(+) TTACTG/AAATTA 1 -- ng318Minor allele frequency- A:0.36EA NA EU WA 558
rs31365331,2
F,H,O156489684(+) TGTCCG/AGCAAA 1 -- ng513Minor allele frequency- A:0.04NA EU WA 270
rs22697141,2
C,F,H156491528(+) TGTCAC/TCTGGA 1 T/I mis1 ese312Minor allele frequency- T:0.26EA NA EU WA 2442
--
rs66600051,2
C,F156490105(+) CTCCAA/GGTCAA 1 -- ng513Minor allele frequency- G:0.17NA 138
rs120608011,2
H156490445(+) CTGTGG/Tttttt 1 -- ng51 tfbs34Minor allele frequency- T:0.00EU EA WA 406
--
rs30872171,2
F156491505(+) CTCAAC/TGAGCC 2 K/N mis11Minor allele frequency- T:0.05NA 40
rs120571661,2
H156490494(+) GATGGT/GTACTG 1 -- ng514Minor allele frequency- G:0.00EU EA WA 414
--
rs168400411,2
F156490683(+) AAAAAG/AAGCAG 1 -- ut513Minor allele frequency- A:0.18NA 142
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HapMap Linkage Disequilibrium images for CD1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 188370

10/15 Novoseek disease relationships for CD1A gene (see all 15 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
langerhans cell histiocytosis 76.06 3 14576638 (1), 18277880 (1)
histiocytosis 69.37 2 17378241 (1), 12717600 (1)
mycosis fungoides 24.13 1 7593815 (1)
barrett esophagus 16.53 2 17308274 (1)
sarcoma 12.75 1 18360746 (1)
tumors 9.23 6 12865628 (1), 16243135 (1), 15914364 (1), 18047662 (1) (see all 5)
autoimmunity 6.23 1 18593354 (1)
infectious disease 4.90 2 9973451 (1), 14991068 (1)
melanoma 0.00 2 9209486 (1), 14512794 (1)
tuberculosis 0.00 1 16034117 (1)
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Human Gene Mutation Database: CD1A
Genetic Association Database: CD1A
Human Genome Epidemiology Navigator: CD1A (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/172 PubMed articles for CD1A gene (see all 172 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 909 HGNC: 1634 AceView: CD1A Ensembl:ENSG00000158477 euGenes: HUgn909
ECgene: CD1A H-InvDB: CD1A
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CD1A:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Predesigned and custom siRNAs for CD1A Antibodies for CD1A
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CD1A Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CD1A

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