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Aliases for CD1A Gene

Aliases for CD1A Gene

  • CD1a Molecule 2 3
  • T-Cell Surface Antigen T6/Leu-6 3 4
  • CD1A Antigen, A Polypeptide 2 3
  • HTa1 Thymocyte Antigen 3 4
  • CD1a Antigen 2 4
  • Epidermal Dendritic Cell Marker CD1a 3
  • Differentiation Antigen CD1-Alpha-3 3
  • Cortical Thymocyte Antigen CD1A 3
  • Cluster Of Differentiation 1 A 3
  • FCB6 3
  • HTA1 3
  • CD1 3
  • R4 3
  • T6 3

External Ids for CD1A Gene

Previous HGNC Symbols for CD1A Gene

  • CD1

Previous GeneCards Identifiers for CD1A Gene

  • GC01P156016
  • GC01P153956
  • GC01P154952
  • GC01P155440
  • GC01P155038
  • GC01P156490
  • GC01P158224
  • GC01P129582

Summaries for CD1A Gene

Entrez Gene Summary for CD1A Gene

  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD1A Gene

CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include langerhans-cell histiocytosis and mycobacterium malmoense. Among its related pathways are Hematopoietic cell lineage. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1C.

UniProtKB/Swiss-Prot for CD1A Gene

  • Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Wiki entry for CD1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD1A Gene

Genomics for CD1A Gene

Regulatory Elements for CD1A Gene

Genomic Location for CD1A Gene

Chromosome:
1
Start:
158,248,329 bp from pter
End:
158,258,269 bp from pter
Size:
9,941 bases
Orientation:
Plus strand

Genomic View for CD1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD1A Gene

Proteins for CD1A Gene

  • Protein details for CD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06126-CD1A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD1a
    Protein Accession:
    P06126
    Secondary Accessions:
    • D3DVD7
    • Q13962
    • Q5TDJ8
    • Q9UMM4
    • Q9Y5M5

    Protein attributes for CD1A Gene

    Size:
    327 amino acids
    Molecular mass:
    37077 Da
    Quaternary structure:
    • Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.
    Miscellaneous:
    • During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface

    Three dimensional structures from OCA and Proteopedia for CD1A Gene

neXtProt entry for CD1A Gene

Proteomics data for CD1A Gene at MOPED

Post-translational modifications for CD1A Gene

  • Ubiquitination at Lys 163 and Lys 195
  • Glycosylation at Asn 37, Asn 60, Asn 74, and Asn 145
  • Modification sites at PhosphoSitePlus

Other Protein References for CD1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD1A Gene

Domains & Families for CD1A Gene

Gene Families for CD1A Gene

Suggested Antigen Peptide Sequences for CD1A Gene

Graphical View of Domain Structure for InterPro Entry

P06126

UniProtKB/Swiss-Prot:

CD1A_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD1A: view

Function for CD1A Gene

Molecular function for CD1A Gene

GENATLAS Biochemistry:
cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)
UniProtKB/Swiss-Prot Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Ontology (GO) - Molecular Function for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12833155
GO:0030881 beta-2-microglobulin binding IBA --
GO:0030883 endogenous lipid antigen binding IBA --
GO:0030884 exogenous lipid antigen binding IBA --
GO:0071723 lipopeptide binding IBA --
genes like me logo Genes that share ontologies with CD1A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD1A Gene

Localization for CD1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD1A Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD1A Gene COMPARTMENTS Subcellular localization image for CD1A gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane NAS 2447586
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with CD1A: view

Pathways & Interactions for CD1A Gene

SuperPathways for CD1A Gene

Superpath Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD1A: view

Pathways by source for CD1A Gene

1 KEGG pathway for CD1A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antigen Presenting Cells in human,mouse,rat
    • Cell Surface Markers in human,mouse,rat

Gene Ontology (GO) - Biological Process for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006955 immune response NAS 2447586
GO:0019882 antigen processing and presentation --
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA --
genes like me logo Genes that share ontologies with CD1A: view

No data available for SIGNOR curated interactions for CD1A Gene

Drugs & Compounds for CD1A Gene

(4) Drugs for CD1A Gene - From: HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antithymocyte globulin Approved Pharma binder, Target, inhibitor 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Agonist Endogenous agonist at S1P1-5 0

(464) Additional Compounds for CD1A Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with CD1A: view

Transcripts for CD1A Gene

mRNA/cDNA for CD1A Gene

Unigene Clusters for CD1A Gene

CD1a molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD1A Gene

No ASD Table

Relevant External Links for CD1A Gene

GeneLoc Exon Structure for
CD1A
ECgene alternative splicing isoforms for
CD1A

Expression for CD1A Gene

mRNA expression in normal human tissues for CD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD1A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x17.2), Skin - Sun Exposed (Lower leg) (x16.4), and Esophagus - Mucosa (x5.2).

Protein differential expression in normal tissues from HIPED for CD1A Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CD1A Gene



SOURCE GeneReport for Unigene cluster for CD1A Gene Hs.1309

mRNA Expression by UniProt/SwissProt for CD1A Gene

P06126-CD1A_HUMAN
Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
genes like me logo Genes that share expression patterns with CD1A: view

Protein tissue co-expression partners for CD1A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CD1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515418 35
  • 73.68 (n)
  • 59.13 (a)
CD1A 36
  • 57 (a)
OneToMany
CD1A 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CD1A6 35
  • 72.58 (n)
  • 58.39 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
CD1A6 36
  • 56 (a)
OneToMany
CD1A8 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CD1A 35
  • 98.31 (n)
  • 96.51 (a)
CD1A 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD1.2 36
  • 23 (a)
ManyToMany
CD1A1 36
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
Species with no ortholog for CD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD1A Gene

ENSEMBL:
Gene Tree for CD1A (if available)
TreeFam:
Gene Tree for CD1A (if available)

Paralogs for CD1A Gene

Paralogs for CD1A Gene

(6) SIMAP similar genes for CD1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD1A: view

Variants for CD1A Gene

Sequence variations from dbSNP and Humsavar for CD1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs366316 -- 158,254,492(+) ATGAG(A/G)GACTG utr-variant-5-prime, intron-variant
rs389293 -- 158,258,602(+) TTACT(A/G)AATTA downstream-variant-500B
rs409237 -- 158,248,722(+) TTTTT(C/G)CCTAG intron-variant
rs411089 -- 158,255,035(+) TCCAT(C/T)CTCTT intron-variant
rs440419 -- 158,255,606(+) TCCCA(G/T)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD1A Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294
nsv508626 CNV Loss 20534489
nsv831692 CNV Gain 17160897
nsv515666 CNV Loss 19592680

Variation tolerance for CD1A Gene

Residual Variation Intolerance Score: 75.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD1A Gene

HapMap Linkage Disequilibrium report
CD1A
Human Gene Mutation Database (HGMD)
CD1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD1A Gene

Disorders for CD1A Gene

MalaCards: The human disease database

(20) MalaCards diseases for CD1A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
langerhans-cell histiocytosis
  • lissencephaly 3
mycobacterium malmoense
  • m. malmoense
cyclosporiasis
  • cyclospora infection
langerhans cell sarcoma
  • malignant langerhans cell sarcoma
myofibroma
  • lipoleiomyoma
- elite association
Search CD1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD1A

Genetic Association Database (GAD)
CD1A
Human Genome Epidemiology (HuGE) Navigator
CD1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD1A
genes like me logo Genes that share disorders with CD1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD1A Gene

Publications for CD1A Gene

  1. Differential immunophenotypic analysis of dendritic cell tumours. (PMID: 20439325) Orii T. … Yamakawa M. (J. Clin. Pathol. 2010) 23 67
  2. Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens. (PMID: 20026739) Cernadas M. … Brenner M.B. (J. Immunol. 2010) 23 67
  3. Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD. (PMID: 20307269) Van Pottelberge G.R. … Brusselle G.G. (Respir. Res. 2010) 23 67
  4. Detection of fascin and CCR-7 positive mature dendritic cells in oral lichen planus. (PMID: 19243493) Mukae S. … Komiyama K. (J. Oral Pathol. Med. 2009) 23 67
  5. CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. (PMID: 19808251) Felio K. … Wang C.R. (J. Exp. Med. 2009) 23 67

Products for CD1A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antigen Presenting Cells in human,mouse,rat
    • Cell Surface Markers in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CD1A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CD1A
  • Block miRNA regulation of CD1A using miScript Target Protectors

Sources for CD1A Gene

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