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CD1A Gene

protein-coding   GIFtS: 64
GCID: GC01P158224

CD1a Molecule

(Previous names: CD1A antigen, a polypeptide, CD1a antigen)
(Previous symbol: CD1)
  See CD1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD1a Molecule1 2     R42
CD11 2     T62
CD1A Antigen, A Polypeptide1 2     Cluster Of Differentiation 1 A2
CD1a Antigen1 3     Cortical Thymocyte Antigen CD1A2
HTa1 Thymocyte Antigen2 3     Differentiation Antigen CD1-Alpha-32
T-Cell Surface Antigen T6/Leu-62 3     Epidermal Dendritic Cell Marker CD1a2
FCB62     T-Cell Surface Glycoprotein CD1a2
HTA12     

External Ids:    HGNC: 16341   Entrez Gene: 9092   Ensembl: ENSG000001584777   OMIM: 1883705   UniProtKB: P061263   

Export aliases for CD1A gene to outside databases

Previous GC identifers: GC01P156016 GC01P153956 GC01P154952 GC01P155440 GC01P155038 GC01P156490 GC01P129582


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD1A Gene:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins
mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The
human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are
thought to differ in their cellular localization and specificity for particular lipid ligands. The protein
encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system.
Alternatively spliced transcript variants have been observed, but their biological validity has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD1A Gene:
CD1A (CD1a molecule) is a protein-coding gene. Diseases associated with CD1A include actinic cheilitis, and cheilitis. GO annotations related to this gene include endogenous lipid antigen binding and beta-2-microglobulin binding. An important paralog of this gene is CD1D.

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells

Gene Wiki entry for CD1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD1A gene promoter:
         Bach1   Brachyury   ATF-2   IRF-1   LCR-F1   POU2F1   POU2F1a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD1A promoter sequence
   Search Chromatin IP Primers for CD1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

CD1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158224:  view genomic region     (about GC identifiers)

Start:
158,223,927 bp from pter      End:
158,228,059 bp from pter
Size:
4,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1a precursor  
Size: 327 amino acids; 37077 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are
replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before
trafficking back to the cell surface
2 PDB 3D structures from and Proteopedia for CD1A:
1ONQ (3D)        1XZ0 (3D)    
Secondary accessions: D3DVD7 Q13962 Q5TDJ8 Q9UMM4 Q9Y5M5

Explore the universe of human proteins at neXtProt for CD1A: NX_P06126

Explore proteomics data for CD1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys163, Lys195
  • Glycosylation2 at Asn37, Asn60, Asn74, Asn145

  • See CD1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001754.2  
    ENSEMBL proteins: 
     ENSP00000289429  

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    Search eBioscience for ELISAs for CD1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR011161 MHC_I-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry P06126

    ProtoNet protein and cluster: P06126

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with CD1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD1A_HUMAN, P06126
    Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
    to T-cell receptors on natural killer T-cells

         Genatlas biochemistry entry for CD1A:
    cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal
    antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12833155
    GO:0030881beta-2-microglobulin binding IBA--
    GO:0030883endogenous lipid antigen binding IBA--
    GO:0030884exogenous lipid antigen binding IBA--
    GO:0071723lipopeptide binding IBA--
         
    Find genes that share ontologies with CD1A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD1A
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CD1A:
    hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCD1A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Sino Biological Human cDNA Clone for CD1A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD1A_HUMAN, P06126: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to
    intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS2447586
    GO:0010008endosome membrane IEA--

    Find genes that share ontologies with CD1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD1A About    
    See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage


    Find genes that share SuperPaths with CD1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD1A):
        Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD1A (P061261, 3 ENSP000002894294) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617691, 3, ENSP000003408584EBI-1036766,EBI-714718 I2D: score=4 STRING: ENSP00000340858
    IGKCENSP000003747774STRING: ENSP00000374777
    TRBV2ENSP000003885234STRING: ENSP00000388523
    AZGP1ENSP000002924014STRING: ENSP00000292401
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS2447586
    GO:0019882antigen processing and presentation ----
    GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA--

    Find genes that share ontologies with CD1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD1A

    Selected HMDB Compounds for CD1A (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    1 DrugBank Compound for CD1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antithymocyte globulinrabbit ATG (see all 3)--targetinhibitor17139284 11752352 17016423

    2 Novoseek inferred chemical compound relationships for CD1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycolipid 76.1 8 12391186 (1), 10352272 (1), 17428545 (1), 11035089 (1) (see all 8)
    lipid 48.3 48 20026739 (4), 17593658 (4), 10487835 (3), 9987600 (3) (see all 32)



    Find genes that share compounds with CD1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD1A gene: 
    NM_001763.2  

    Unigene Cluster for CD1A:

    CD1a molecule
    Hs.1309  [show with all ESTs]
    Unigene Representative Sequence: NM_001763
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000289429(uc001frt.3 uc021pbk.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CD1A:
    hsa-miR-589*
    SwitchGear 3'UTR luciferase reporter plasmidCD1A 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CD1A

    Additional mRNA sequence: 

    AK312945.1 BC031645.1 M27735.1 M28825.1 X04450.1 

    8 DOTS entries:

    DT.100776245  DT.121377677  DT.121377701  DT.111387  DT.121377691  DT.92416233  DT.100644955  DT.121377683 

    Selected AceView cDNA sequences (see all 30):

    CA432941 AA310607 AI581337 X79308 BG679322 L44433 CR603267 BX281603 
    AA354298 M27735 NM_001763 M28825 BX414919 BC031645 BI828464 AW303389 
    AI240210 X04450 AW949640 BV202113 AA310389 AA731869 AA354975 AA916250 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCAATAA
    CD1A Expression
    About this image


    CD1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 5 entries
             Double Negative 3 Thymocytes Thymus
             Thymus   
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             Double Negative 3 Thymocytes Thymus
             monocyte-derived dendritic cells   
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Dendritic-like cells
             skin 1 ; Langerhans   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived multipotent stem cells

     --
             skin 1 ; Langerhans   
    CD1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1309

    UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
    Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain
    T-cell leukemias, and in various other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD1A: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD1A
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    QuantiFast Probe-based Assays in human, mouse, rat CD1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD1A gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CD1A61 CD1a6 molecule 72.58(n)
    58.39(a)
      488608  NM_001128837.1  NP_001122309.1 
    chicken
    (Gallus gallus)
    Aves CD1.26
    CD1A16
    Gallus gallus CD1c molecule (CD1C), mRNA.
    23(a)
    23(a)
    many ↔ many
    many ↔ many
    16(5769-8509)
    16(2102-4938)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    2(189404875-189415760)


    ENSEMBL Gene Tree for CD1A (if available)
    TreeFam Gene Tree for CD1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD1A gene
    CD1D2  CD1B2  CD1C2  CD1E2  
    6 SIMAP similar genes for CD1A using alignment to 2 protein entries:     CD1A_HUMAN (see all proteins):
    CDIE    CD1C    CD1E    CD1D    CD1B    B2M

    Find genes that share paralogs with CD1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD1A (see all 261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898285211,2
    --129580005(+) GCCACC/TGCACC 1 -- us2k10--------
    rs1830054381,2
    C--129580006(+) CCACCA/GCACCC 1 -- us2k10--------
    rs1879134961,2
    --129580012(+) CACCCA/GGCCAC 1 -- us2k10--------
    rs1929660291,2
    --158222097(+) AAAGGC/TTTAGA 1 -- us2k10--------
    rs1164115351,2
    C,F--158222245(+) AACAAG/AGGTTT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1830944191,2
    --158222254(+) TTGCAC/TTCCAT 1 -- us2k10--------
    rs1508384051,2
    C--158222458(+) TGGGA-/GGGCTG 1 -- us2k10--------
    rs1872556411,2
    --158222466(+) CTGAGA/GCAGGT 1 -- us2k10--------
    rs1453864191,2
    --158222611(+) TTAACA/CTGGGA 1 -- us2k10--------
    rs618187151,2
    C--158222676(+) GAGTGG/AGACTC 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CD1A (158223927 - 158228059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515666CNV Loss19592680
    nsv508626CNV Loss20534489
    dgv393n71CNV Gain21882294
    nsv831692CNV Gain17160897

    Human Gene Mutation Database (HGMD): CD1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD1A
    DNA2.0 Custom Variant and Variant Library Synthesis for CD1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188370    OMIM disorders: --

    12 diseases for CD1A:    
    About MalaCards
    actinic cheilitis    cheilitis    generalized eruptive histiocytosis    mycobacterium malmoense
    langerhans-cell histiocytosis    langerhans cell sarcoma    multifocal motor neuropathy    histiocytosis
    oral lichen planus    mycosis fungoides    pharyngitis    epidermodysplasia verruciformis

    1 disease from the University of Copenhagen DISEASES database for CD1A:
    Langerhans-cell histiocytosis

    Find genes that share disorders with CD1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD1A gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    langerhans cell histiocytosis 77 4 14576638 (1), 20439325 (1), 18277880 (1)
    histiocytosis 68.2 2 17378241 (1), 12717600 (1)
    eosinophilic granuloma 58.8 1 20074763 (1)
    sarcoma 23.8 2 18360746 (1), 20439325 (1)
    mycosis fungoides 22.4 1 7593815 (1)
    tuberculosis 18.3 2 19808251 (1), 16034117 (1)
    barrett esophagus 14.5 2 17308274 (1)
    tumors 9.99 7 12865628 (1), 16243135 (1), 15914364 (1), 18047662 (1) (see all 6)
    autoimmunity 3.87 1 18593354 (1)
    infectious disease 2.34 2 9973451 (1), 14991068 (1)

    Genetic Association Database (GAD): CD1A
    Human Genome Epidemiology (HuGE) Navigator: CD1A (9 documents)

    Export disorders for CD1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD1A gene, integrated from 10 sources (see all 215):
    (articles sorted by number of sources associating them with CD1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. (PubMed id 2784820)1, 2, 3 Longley J.... Edelson R. (J. Invest. Dermatol. 1989)
    2. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)1, 2, 3 Martin L.H.... Milstein C. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    3. Susceptibility to Guillain-BarrAc syndrome is not associated with CD1A and CD1E gene polymorphisms. (PubMed id 18838176)1, 4, 9 Kuijf M.L....Jacobs B.C. (J. Neuroimmunol. 2008)
    4. Polymorphisms of CD1 genes in chronic dysimmune neuropathies. (PubMed id 17428545)1, 4, 9 De Angelis M.V....Uncini A. (J. Neuroimmunol. 2007)
    5. Susceptibility to Guillain-BarrAc syndrome is associated to polymorphisms of CD1 genes. (PubMed id 16820217)1, 4, 9 Caporale C.M....Uncini A. (J. Neuroimmunol. 2006)
    6. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 4, 9 Jones D.C....Bunce M. (Tissue Antigens 2001)
    7. Association of CD1A +622 T/C, +737 G/C and CD1E +6129 A/G genes polymorphisms with multiple sclerosis. (PubMed id 20954848)1, 4 Jamshidian A....Kamali-Sarvestani E. (Immunol. Invest. 2010)
    8. Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. (PubMed id 18178838)1, 2 Sloma I.... Gelin C. (J. Immunol. 2008)
    9. CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. (PubMed id 16272286)1, 2 Vincent M.S.... Brenner M.B. (J. Immunol. 2005)
    10. Molecular mechanism of lipopeptide presentation by CD1a. (PubMed id 15723809)1, 2 Zajonc D.M.... Wilson I.A. (Immunity 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 909 HGNC: 1634 AceView: CD1A Ensembl:ENSG00000158477 euGenes: HUgn909
    ECgene: CD1A Kegg: 909 H-InvDB: CD1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CD1A gene:
    Search GeneIP for patents involving CD1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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