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Aliases for CD1A Gene

Aliases for CD1A Gene

  • CD1a Molecule 2 3 5
  • T-Cell Surface Antigen T6/Leu-6 3 4
  • CD1A Antigen, A Polypeptide 2 3
  • HTa1 Thymocyte Antigen 3 4
  • CD1a Antigen 2 4
  • Epidermal Dendritic Cell Marker CD1a 3
  • Differentiation Antigen CD1-Alpha-3 3
  • Cortical Thymocyte Antigen CD1A 3
  • Cluster Of Differentiation 1 A 3
  • FCB6 3
  • HTA1 3
  • CD1 3
  • R4 3
  • T6 3

External Ids for CD1A Gene

Previous HGNC Symbols for CD1A Gene

  • CD1

Previous GeneCards Identifiers for CD1A Gene

  • GC01P156016
  • GC01P153956
  • GC01P154952
  • GC01P155440
  • GC01P155038
  • GC01P156490
  • GC01P158224
  • GC01P129582

Summaries for CD1A Gene

Entrez Gene Summary for CD1A Gene

  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for CD1A Gene

CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include langerhans-cell histiocytosis and histiocytosis. Among its related pathways are Immune System and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1C.

UniProtKB/Swiss-Prot for CD1A Gene

  • Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Wiki entry for CD1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD1A Gene

Genomics for CD1A Gene

Regulatory Elements for CD1A Gene

Genomic Location for CD1A Gene

Chromosome:
1
Start:
158,248,329 bp from pter
End:
158,258,269 bp from pter
Size:
9,941 bases
Orientation:
Plus strand

Genomic View for CD1A Gene

Genes around CD1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD1A Gene

Proteins for CD1A Gene

  • Protein details for CD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06126-CD1A_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD1a
    Protein Accession:
    P06126
    Secondary Accessions:
    • D3DVD7
    • Q13962
    • Q5TDJ8
    • Q9UMM4
    • Q9Y5M5

    Protein attributes for CD1A Gene

    Size:
    327 amino acids
    Molecular mass:
    37077 Da
    Quaternary structure:
    • Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.
    Miscellaneous:
    • During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

    Three dimensional structures from OCA and Proteopedia for CD1A Gene

neXtProt entry for CD1A Gene

Proteomics data for CD1A Gene at MOPED

Post-translational modifications for CD1A Gene

  • Ubiquitination at Lys 163 and Lys 195
  • Glycosylation at Asn 37, Asn 60, Asn 74, and Asn 145
  • Modification sites at PhosphoSitePlus

Other Protein References for CD1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD1A Gene

Domains & Families for CD1A Gene

Gene Families for CD1A Gene

Suggested Antigen Peptide Sequences for CD1A Gene

Graphical View of Domain Structure for InterPro Entry

P06126

UniProtKB/Swiss-Prot:

CD1A_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD1A: view

Function for CD1A Gene

Molecular function for CD1A Gene

GENATLAS Biochemistry:
cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)
UniProtKB/Swiss-Prot Function:
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Gene Ontology (GO) - Molecular Function for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071723 lipopeptide binding IBA --
genes like me logo Genes that share ontologies with CD1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD1A Gene

Localization for CD1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD1A Gene

Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838). {ECO:0000269 PubMed:11231314, ECO:0000269 PubMed:18178838}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD1A Gene COMPARTMENTS Subcellular localization image for CD1A gene
Compartment Confidence
plasma membrane 5
endosome 3
cytosol 2
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with CD1A: view

Pathways & Interactions for CD1A Gene

genes like me logo Genes that share pathways with CD1A: view

Pathways by source for CD1A Gene

Gene Ontology (GO) - Biological Process for CD1A Gene

None

No data available for SIGNOR curated interactions for CD1A Gene

Drugs & Compounds for CD1A Gene

(4) Drugs for CD1A Gene - From: HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antithymocyte globulin Approved Pharma binder, Target, inhibitor 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(464) Additional Compounds for CD1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with CD1A: view

Transcripts for CD1A Gene

mRNA/cDNA for CD1A Gene

Unigene Clusters for CD1A Gene

CD1a molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD1A Gene

No ASD Table

Relevant External Links for CD1A Gene

GeneLoc Exon Structure for
CD1A
ECgene alternative splicing isoforms for
CD1A

Expression for CD1A Gene

mRNA expression in normal human tissues for CD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD1A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x17.2), Skin - Sun Exposed (Lower leg) (x16.4), and Esophagus - Mucosa (x5.2).

Protein differential expression in normal tissues from HIPED for CD1A Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD1A Gene



SOURCE GeneReport for Unigene cluster for CD1A Gene Hs.1309

mRNA Expression by UniProt/SwissProt for CD1A Gene

P06126-CD1A_HUMAN
Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
genes like me logo Genes that share expression patterns with CD1A: view

Protein tissue co-expression partners for CD1A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515418 35
  • 73.68 (n)
  • 59.13 (a)
CD1A 36
  • 57 (a)
OneToMany
CD1A 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CD1A6 35
  • 72.58 (n)
  • 58.39 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
CD1A6 36
  • 56 (a)
OneToMany
CD1A8 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CD1A 35
  • 98.31 (n)
  • 96.51 (a)
CD1A 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD1.2 36
  • 23 (a)
ManyToMany
CD1A1 36
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
Species with no ortholog for CD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD1A Gene

ENSEMBL:
Gene Tree for CD1A (if available)
TreeFam:
Gene Tree for CD1A (if available)

Paralogs for CD1A Gene

Paralogs for CD1A Gene

(6) SIMAP similar genes for CD1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD1A: view

Variants for CD1A Gene

Sequence variations from dbSNP and Humsavar for CD1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2269714 - 158,255,114(+) TGTCA(A/C/T)CTGGA reference, missense
rs2269715 - 158,255,229(+) CTGTG(C/G)CCCTG reference, missense
rs3087217 - 158,255,091(-) CTCAA(C/T)GAGCC reference, synonymous-codon
rs389293 -- 158,258,602(+) TTACT(A/G)AATTA downstream-variant-500B
rs366316 -- 158,254,492(+) ATGAG(A/G)GACTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CD1A Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294
nsv508626 CNV Loss 20534489
nsv831692 CNV Gain 17160897
nsv515666 CNV Loss 19592680

Variation tolerance for CD1A Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD1A Gene

HapMap Linkage Disequilibrium report
CD1A
Human Gene Mutation Database (HGMD)
CD1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD1A Gene

Disorders for CD1A Gene

MalaCards: The human disease database

(16) MalaCards diseases for CD1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
langerhans-cell histiocytosis
  • histiocytosis x
histiocytosis
  • chronic histiocytosis x
mycobacterium malmoense
  • m. malmoense
cyclosporiasis
  • cyclospora infection
dendritic cell tumor
  • dendritic cell sarcoma, not otherwise specified
- elite association - COSMIC cancer census association via MalaCards
Search CD1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD1A

Genetic Association Database (GAD)
CD1A
Human Genome Epidemiology (HuGE) Navigator
CD1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD1A
genes like me logo Genes that share disorders with CD1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD1A Gene

Publications for CD1A Gene

  1. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. (PMID: 2784820) Longley J. … Edelson R. (J. Invest. Dermatol. 1989) 2 3 4 67
  2. Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens. (PMID: 20026739) Cernadas M. … Brenner M.B. (J. Immunol. 2010) 3 23
  3. CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome. (PMID: 18184269) La Rocca G. … Cappello F. (Histopathology 2008) 3 23
  4. IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa. (PMID: 18337560) Smed-SAPrensen A. … Sandberg J.K. (Blood 2008) 3 23
  5. Susceptibility to Guillain-BarrAc syndrome is not associated with CD1A and CD1E gene polymorphisms. (PMID: 18838176) Kuijf M.L. … Jacobs B.C. (J. Neuroimmunol. 2008) 3 23

Products for CD1A Gene

Sources for CD1A Gene

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