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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD1A Gene

protein-coding   GIFtS: 64
GCID: GC01P158224

CD1a Molecule

(Previous names: CD1A antigen, a polypeptide, CD1a antigen)
(Previous symbol: CD1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD1a Molecule1 2     R42
CD11 2     T62
CD1A Antigen, A Polypeptide1 2     Cluster Of Differentiation 1 A2
CD1a Antigen1 3     Cortical Thymocyte Antigen CD1A2
HTa1 Thymocyte Antigen2 3     Differentiation Antigen CD1-Alpha-32
T-Cell Surface Antigen T6/Leu-62 3     Epidermal Dendritic Cell Marker CD1a2
FCB62     T-Cell Surface Glycoprotein CD1a2
HTA12     

External Ids:    HGNC: 16341   Entrez Gene: 9092   Ensembl: ENSG000001584777   OMIM: 1883705   UniProtKB: P061263   

Export aliases for CD1A gene to outside databases

Previous GC identifers: GC01P156016 GC01P153956 GC01P154952 GC01P155440 GC01P155038 GC01P156490 GC01P129582


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD1A Gene:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins
mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The
human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are
thought to differ in their cellular localization and specificity for particular lipid ligands. The protein
encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system.
Alternatively spliced transcript variants have been observed, but their biological validity has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD1A Gene: 
CD1A (CD1a molecule) is a protein-coding gene. Diseases associated with CD1A include generalized eruptive histiocytosis, and cheilitis. GO annotations related to this gene include protein binding. An important paralog of this gene is CD1D.

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells

Gene Wiki entry for CD1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD1A gene promoter:
         Bach1   Brachyury   ATF-2   IRF-1   LCR-F1   POU2F1   POU2F1a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD1A promoter sequence
   Search SABiosciences Chromatin IP Primers for CD1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22-q23

CD1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158224:  view genomic region     (about GC identifiers)

Start:
158,223,927 bp from pter      End:
158,228,059 bp from pter
Size:
4,133 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD1a precursor  
Size: 327 amino acids; 37077 Da
Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to
intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are
replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before
trafficking back to the cell surface
2 PDB 3D structures from and Proteopedia for CD1A:
1ONQ (3D)        1XZ0 (3D)    
Secondary accessions: D3DVD7 Q13962 Q5TDJ8 Q9UMM4 Q9Y5M5

Explore the universe of human proteins at neXtProt for CD1A: NX_P06126

Explore proteomics data for CD1A at MOPED 

CD1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CD1A Protein Expression

REFSEQ proteins: NP_001754.2  
ENSEMBL proteins: 
 ENSP00000289429  

Human Recombinant Protein Products for CD1A: 
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Novus Biologicals CD1A Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral to plasma membrane NAS2447586
GO:0010008endosome membrane IEA--
GO:0042612MHC class I protein complex ----

CD1A for ontologies           About GeneDecksing



CD1A Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of CD1A
R&D Systems Antibodies for CD1A
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Novus Biologicals CD1A Antibodies
Abcam antibodies for CD1A
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibody for CD1A
LSBio Antibodies in human, mouse, rat for CD1A 

Assay Products for CD1A: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CD1A
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CD1A
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
C1SET: Immunoglobulin superfamily / C1-set domain containing

5/6 InterPro protein domains (see all 6):
 IPR011162 MHC_I/II-like_Ag-recog
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR011161 MHC_I-like_Ag-recog

Graphical View of Domain Structure for InterPro Entry P06126

ProtoNet protein and cluster: P06126

1 Blocks protein domain: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


CD1A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CD1A_HUMAN, P06126
Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them
to T-cell receptors on natural killer T-cells

     Genatlas biochemistry entry for CD1A:
cell differentiation antigen CD1A (T6),49kDa,membrane glycoprotein,B2M associated,identified by monoclonal
antibodies NA1/34,T6,VIT6,Leu6 (see CD1@)

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI12833155
GO:0030881beta-2-microglobulin binding IBA--
GO:0030883endogenous lipid antigen binding IBA--
GO:0030884exogenous lipid antigen binding IBA--
GO:0071723lipopeptide binding IBA--
     
CD1A for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CD1A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD1A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD1A 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD1A 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD1A
1 QIAGEN miScript miRNA Assays for microRNA that regulate CD1A:
hsa-miR-589*
SwitchGear 3'UTR luciferase reporter plasmidCD1A 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CD1A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CD1A
Sirion Biotech Customized adenovirus for overexpression of CD1A

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CD1A (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CD1A (NM_001763)
Sino Biological Human cDNA Clone for CD1A
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD1A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1A
Sirion Biotech Customized lentivirus for stable overexpression of CD1A 
                     Customized lentivirus expression plasmids for stable overexpression of CD1A 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CD1A
Search LifeMap BioReagents cell lines for CD1A
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CD1A About                                                                                                See pathways by source

SuperPathContained pathways About
1Hematopoietic cell lineage
Hematopoietic cell lineage

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




1         Kegg Pathway  (Kegg details for CD1A):
    Hematopoietic cell lineage


CD1A for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for CD1A (P061261, 3 ENSP000002894294) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
InteractantInteraction Details
GeneCardExternal ID(s)
B2MP617691, 3, ENSP000003408584EBI-1036766,EBI-714718 I2D: score=4 STRING: ENSP00000340858
AZGP1ENSP000002924014STRING: ENSP00000292401
ENSG00000206435ENSP000003729754STRING: ENSP00000372975
ENSG00000206452ENSP000003832454STRING: ENSP00000383245
ENSG00000206493ENSP000003730914STRING: ENSP00000373091
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS2447586
GO:0019882antigen processing and presentation ----
GO:0048007antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA--

CD1A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD1A for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD1A

10/519 HMDB Compounds for CD1A (see all 519)    About this table
CompoundSynonyms CAS #PubMed Ids
3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

1 DrugBank Compound for CD1A    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Antithymocyte globulinrabbit ATG (see all 3)--targetinhibitor17139284 11752352 17016423

2 Novoseek inferred chemical compound relationships for CD1A gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glycolipid 76.1 8 12391186 (1), 10352272 (1), 17428545 (1), 11035089 (1) (see all 8)
lipid 48.3 48 20026739 (4), 17593658 (4), 10487835 (3), 9987600 (3) (see all 32)

Search CenterWatch for drugs/clinical trials and news about CD1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD1A gene: 
NM_001763.2  

Unigene Cluster for CD1A:

CD1a molecule
Hs.1309  [show with all ESTs]
Unigene Representative Sequence: NM_001763
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000289429(uc001frt.3 uc021pbk.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD1A
1 QIAGEN miScript miRNA Assays for microRNA that regulate CD1A:
hsa-miR-589*
SwitchGear 3'UTR luciferase reporter plasmidCD1A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CD1A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD1A
Clone
Products:
     
OriGene clones in human, mouse for CD1A (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CD1A (NM_001763)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD1A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD1A
Sirion Biotech Customized lentivirus for stable overexpression of CD1A 
                     Customized lentivirus expression plasmids for stable overexpression of CD1A 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CD1A
OriGene qSTAR qPCR primer pairs in human, mouse for CD1A
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD1A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1A

Additional mRNA sequence: 

AK312945.1 BC031645.1 M27735.1 M28825.1 X04450.1 

8 DOTS entries:

DT.100776245  DT.121377677  DT.121377701  DT.111387  DT.121377691  DT.92416233  DT.100644955  DT.121377683 

24/30 AceView cDNA sequences (see all 30):

X79308 BX281603 AA310607 AA354298 CA432941 L44433 BG679322 AI581337 
CR603267 M28825 AI240210 AW303389 BX414919 NM_001763 X04450 AW949640 
M27735 BC031645 BV202113 BI828464 AA354975 AA310389 AA731869 AV716124 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD1A expression in normal human tissues (normalized intensities)      CD1A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTCAATAA
CD1A Expression
About this image


CD1A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 7 entries
         Double Negative 3 Thymocytes Thymus
         Dendritic-like cells ( Generation of hematopoietic progenitor cells and matured blood...
         monocyte-derived dendritic cells   
 
 Thymus (Hematopoietic System)    fully expand to see all 5 entries
         Double Negative 3 Thymocytes Thymus
         Thymus   
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical cord blood-derived multipotent stem cells
 
 Epithelium (Uncategorized)
         head and neck epithelial cells   
 
 Spleen (Hematopoietic System)
         spleen ; cells in white pulp   

See CD1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD1A

SOURCE GeneReport for Unigene cluster: Hs.1309

UniProtKB/Swiss-Prot: CD1A_HUMAN, P06126
Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain
T-cell leukemias, and in various other tissues

    SABiosciences Expression via Pathway-Focused PCR Arrays including CD1A: 
          Cell Surface Markers in human mouse rat
          Antigen Presenting Cells in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CD1A
OriGene qSTAR qPCR primer pairs in human, mouse for CD1A
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD1A
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD1A
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD1A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD1A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD1A gene from 3/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia CD1A61 CD1a6 molecule 72.15(n)
59.01(a)
  488608  NM_001128837.1  NP_001122309.1 
chicken
(Gallus gallus)
Aves CD1A16
CD1.26
T-cell surface glycoprotein CD1b precursor
22(a)
21(a)
many ↔ many
many ↔ many
16(2102-4938)
16(5769-8509)
lizard
(Anolis carolinensis)
Reptilia --
--
24(a)
1 → many
2(189404875-189415760)


ENSEMBL Gene Tree for CD1A (if available)
TreeFam Gene Tree for CD1A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CD1A gene
CD1D2  CD1B2  CD1C2  CD1E2  
6 SIMAP similar genes for CD1A using alignment to 2 protein entries:     CD1A_HUMAN (see all proteins):
CDIE    CD1C    CD1E    CD1D    CD1B    B2M

CD1A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/261 SNPs in CD1A are shown (see all 261)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1898285211,2
--129580005(+) GCCACC/TGCACC 1 -- us2k10--------
rs1830054381,2
C--129580006(+) CCACCA/GCACCC 1 -- us2k10--------
rs1879134961,2
--129580012(+) CACCCA/GGCCAC 1 -- us2k10--------
rs1929660291,2
--158222097(+) AAAGGC/TTTAGA 1 -- us2k10--------
rs1164115351,2
C,F--158222245(+) AACAAG/AGGTTT 1 -- us2k11Minor allele frequency- A:0.01NA 120
rs1830944191,2
--158222254(+) TTGCAC/TTCCAT 1 -- us2k10--------
rs1508384051,2
C--158222458(+) TGGGA-/GGGCTG 1 -- us2k10--------
rs1872556411,2
--158222466(+) CTGAGA/GCAGGT 1 -- us2k10--------
rs1453864191,2
--158222611(+) TTAACA/CTGGGA 1 -- us2k10--------
rs618187151,2
C--158222676(+) GAGTGG/AGACTC 1 -- us2k11Minor allele frequency- A:0.50NA 2

HapMap Linkage Disequilibrium report for CD1A (158223927 - 158228059 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for CD1A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv515666CNV Loss19592680
nsv508626CNV Loss20534489
dgv393n71CNV Gain21882294
nsv831692CNV Gain17160897


Human Gene Mutation Database (HGMD): CD1A
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 188370    OMIM disorders: --

20/57 diseases for CD1A (see all 57):    About MalaCards
generalized eruptive histiocytosis    cheilitis    actinic cheilitis    cyclosporiasis
langerhans cell sarcoma    oral lichen planus    mycobacterium malmoense    langerhans-cell histiocytosis
cystic teratoma    epidermodysplasia verruciformis    histiocytosis    mycosis fungoides
multifocal motor neuropathy    aggressive periodontitis    guillain-barre syndrome    acute monocytic leukemia
abetalipoproteinemia    teratoma    barrett's esophagus    lichen planus

1 disease from the University of Copenhagen DISEASES database for CD1A:
Langerhans-cell histiocytosis

CD1A for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/16 Novoseek inferred disease relationships for CD1A gene (see all 16)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
langerhans cell histiocytosis 77 4 14576638 (1), 20439325 (1), 18277880 (1)
histiocytosis 68.2 2 17378241 (1), 12717600 (1)
eosinophilic granuloma 58.8 1 20074763 (1)
sarcoma 23.8 2 18360746 (1), 20439325 (1)
mycosis fungoides 22.4 1 7593815 (1)
tuberculosis 18.3 2 19808251 (1), 16034117 (1)
barrett esophagus 14.5 2 17308274 (1)
tumors 9.99 7 12865628 (1), 16243135 (1), 15914364 (1), 18047662 (1) (see all 6)
autoimmunity 3.87 1 18593354 (1)
infectious disease 2.34 2 9973451 (1), 14991068 (1)

Genetic Association Database (GAD): CD1A
Human Genome Epidemiology (HuGE) Navigator: CD1A (9 documents)

Export disorders for CD1A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CD1A gene, integrated from 9 sources (see all 214):
(articles sorted by number of sources associating them with CD1A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. (PubMed id 2784820)1, 2, 3 Longley J.... Edelson R. (1989)
  2. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. (PubMed id 2447586)1, 2, 3 Martin L.H.... Milstein C. (1987)
  3. Susceptibility to Guillain-Barre syndrome is not associated with CD1A and CD1E gene polymorphisms. (PubMed id 18838176)1, 4, 9 Kuijf M.L....Jacobs B.C. (2008)
  4. Polymorphisms of CD1 genes in chronic dysimmune neuropathies. (PubMed id 17428545)1, 4, 9 De Angelis M.V....Uncini A. (2007)
  5. Susceptibility to Guillain-Barre syndrome is associated to polymorphisms of CD1 genes. (PubMed id 16820217)1, 4, 9 Caporale C.M....Uncini A. (2006)
  6. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. (PubMed id 11580851)1, 4, 9 Jones D.C....Bunce M. (2001)
  7. Association of CD1A +622 T/C, +737 G/C and CD1E +6129 A/G genes polymorphisms with multiple sclerosis. (PubMed id 20954848)1, 4 Jamshidian A....Kamali-Sarvestani E. (2010)
  8. Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. (PubMed id 18178838)1, 2 Sloma I.... Gelin C. (2008)
  9. CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. (PubMed id 16272286)1, 2 Vincent M.S.... Brenner M.B. (2005)
  10. Molecular mechanism of lipopeptide presentation by CD1a. (PubMed id 15723809)1, 2 Zajonc D.M....Wilson I.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 909 HGNC: 1634 AceView: CD1A Ensembl:ENSG00000158477 euGenes: HUgn909
ECgene: CD1A Kegg: 909 H-InvDB: CD1A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CD1A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CD1A gene:
Search GeneIP for patents involving CD1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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