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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD19 Gene

protein-coding GIFtS: 69
GCID: GC16P028943

CD19 molecule

(Previous name: CD19 antigen )

Explore 48 diseases affiliated with
CD19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD19 Molecule¹ ²		T-Cell Surface Antigen Leu-12² ³
CD19 Antigen¹ ³		CVID3² ⁵
Differentiation Antigen CD19² ³		B4²
B-Lymphocyte Surface Antigen B4² ³		B-Lymphocyte Antigen CD19²

External Ids:	HGNC: 1633¹	Entrez Gene: 930²	Ensembl: ENSG00000177455⁷	OMIM: 107265⁵	UniProtKB: P15391³

Export aliases for CD19 gene to outside databases

Previous GC identifers: GC16U990011 GC16P029266 GC16P028941 GC16P028980 GC16P028850 GC16P026811

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD19:

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of

the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of

low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of

B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: CD19_HUMAN, P15391

Function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen

receptor-dependent stimulation

Gene Wiki entry for CD19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD19 gene promoter:
STAT1 AP-1 ATF-2 STAT1alpha CRE-BP1 STAT3 c-Jun ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD19 promoter sequence

Search SABiosciences Chromatin IP Primers for CD19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

CD19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD19 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P028943: view genomic region (about GC identifiers)

Start:	28,943,260 bp from pter	End:	28,950,668 bp from pter
Size:	7,409 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD19_HUMAN, P15391 (See protein sequence)

Recommended Name: B-lymphocyte antigen CD19 precursor

Size: 556 amino acids; 61128 Da

Subunit: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts

with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.

Interacts with LYN

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=AAA35533.1; Type=Frameshift; Positions=396;

Secondary accessions: A0N0P9 Q96S68 Q9BRD6

Explore the universe of human proteins at neXtProt for CD19: NX_P15391

Post-translational modifications:

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following

B-cell activation. Phosphorylated on tyrosine residues by LYN¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15391

CD19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171569.1 NP_001761.3

ENSEMBL proteins:

ENSP00000313419 ENSP00000456201 ENSP00000437940

Reactome Protein details: P15391
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD19 OriGene Protein Over-expression Lysate: CD19 OriGene Custom Protein Services for CD19
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	Novus Biologicals CD19 Proteins Novus Biologicals CD19 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD19

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	2472450
GO:0009897	external side of plasma membrane	IDA	--

CD19 for ontologies About GeneDecksing

CD19 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD19
	R&D Systems Antibodies for CD19
	Cell Signaling Technology (CST) Antibodies for CD19
	OriGene Antibodies (see all 13): CD19 OriGene Custom Antibody Services for CD19
	GenScript Custom Superior Antibodies Services for CD19
	Novus Biologicals CD19 Antibodies
	Abcam antibodies for CD19
	Uscn Antibodies for CD19
	ThermoFisher Antibody for CD19

Assay Products for CD19:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD19
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD19

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD19 for domains About GeneDecksing

3 InterPro domains/families:

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P15391

ProtoNet protein and cluster: P15391

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: CD19_HUMAN, P15391

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD19_HUMAN, P15391

Function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen

receptor-dependent stimulation

Genatlas biochemistry entry for CD19:

cell differentiation antigen CD19,95kDa,B cell surface membrane protein PAX5 (BSAP) dependent,identified by monoclonal

antibodies B4,HD37 and others ,linked to the integrin associated CD9,CD81,KAI1

miRNA Products:		OriGene 3'-UTR Clone: CD19 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD19
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD19:
		hsa-miR-3934 hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: CD19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD19 (see all 7) OriGene shRNA RFP: CD19 OriGene siRNA: CD19
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD19

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD19

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD19 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD19 (NM_001770)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD19
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD19

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD19
		Search LifeMap BioReagents cell lines for CD19

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD19

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	TAS	1373518

CD19 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CD19:

Increased S DNA content

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Cd19^tm1Tft for CD19
15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd19):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	nervous system	normal	renal/urinary system	tumorigenesis

CD19 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB4 signaling	1.00	Signaling by SCF-KIT	0.72

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

B cell receptor signaling pathway

	B cell receptor signaling pathway	1.00			PI3K Signaling in B-Lymphocyte	0.35
	BCR signaling pathway	0.41

G-protein signaling Regulation of RAC1 activity

G-protein signaling Regulation of RAC1 activity

1.00

G-protein signaling_Regulation of RAC1 activity

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CD19

	Immune response BCR pathway
	G-protein signaling Regulation of RAC1 activity

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD19

	p70S6K Signaling
	IP3 Pathway
	PI3K Signaling in B-Lymphocyte

1 Cell Signaling Technology (CST) Pathway for CD19

Lymphocyte Signaling

2 GeneGo (Thomson Reuters) Pathways for CD19

	G-protein signaling Regulation of RAC1 activity
	Immune response BCR pathway

2 BioSystems Pathways for CD19

	B Cell Receptor Signaling Pathway
	BCR signaling pathway

5/32 Reactome Pathways for CD19 (see all 32)

	Signaling by EGFR in Cancer
	Disease
	Signaling by ERBB2
	GAB1 signalosome
	PI3K/AKT activation

3 Kegg Pathways (Kegg details for CD19):

	Hematopoietic cell lineage
	B cell receptor signaling pathway
	Primary immunodeficiency

CD19 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD19

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for CD19 (P15391^{2, 3} ENSP00000313419⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BTK	Q06187²^,³, ENSP00000308176⁴	MINT-7230949 MINT-7230932 MINT-7230971 I2D: score=3 STRING: ENSP00000308176
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8028100 MINT-8037707 I2D: score=5 STRING: ENSP00000274335
ARID3A	Q99856², ENSP00000263620⁴	MINT-7230949 MINT-7230932 MINT-7230971 STRING: ENSP00000263620
CD81	P60033²^,³, ENSP00000263645⁴	MINT-8407185 I2D: score=3 STRING: ENSP00000263645
CD9	P21926²^,³, ENSP00000009180⁴	MINT-8407185 I2D: score=3 STRING: ENSP00000009180

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006968	cellular defense response	TAS	1373518
GO:0007166	cell surface receptor signaling pathway	TAS	1714482
GO:0050776	regulation of immune response	TAS	--
GO:0050853	B cell receptor signaling pathway	--	--

CD19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD19 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD19
6 Novoseek chemical compound relationships for CD19 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ricin	48.3	2	1370636 (1)
phosphatidylinositol	40.1	8	9808169 (2), 7688513 (1), 10201980 (1), 9190913 (1) (see all 5)
tyrosine	27.4	25	9808169 (3), 9200454 (3), 12938232 (2), 10933394 (2) (see all 12)
doxorubicin	9.47	2	10825443 (1)
lipid	0	3	9620684 (2), 11713294 (1)
calcium	0	3	9620684 (1), 11584010 (1)

Search CenterWatch for drugs/clinical trials and news about CD19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD19 gene (2 alternative transcripts):

NM_001178098.1 NM_001770.5

Unigene Cluster for CD19:

CD19 molecule

Hs.652262 [show with all ESTs]

Unigene Representative Sequence: BC052294

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000324662 ENST00000565089 ENST00000567541 ENST00000566890 ENST00000567368

ENST00000538922(uc010byo.2 uc002drs.3)

miRNA Products:		OriGene 3'-UTR Clone: CD19 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD19
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD19:
		hsa-miR-3934 hsa-miR-205*
		SwitchGear 3'UTR luciferase reporter plasmid: CD19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD19 (see all 7) OriGene shRNA RFP: CD19 OriGene siRNA: CD19
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD19 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD19 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD19 (NM_001770)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD19

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD19

Additional cDNA sequence:

AK130657.1 AK301167.1 AK301363.1 AK304456.1 AK307295.1 AK313577.1 BC006338.2 BC052294.1

M21097.1 X13312.1

6 DOTS entries:

DT.454928 DT.99961528 DT.95082330 DT.95268084 DT.91833223 DT.95268082

24/58 AceView cDNA sequences (see all 58):

BQ055377 BG258419 AW574858 NM_001770 BI769680 BX094429 AK130657 BC006338

BP340570 BP340638 BC052294 AW402245 BQ066405 BI520006 BG340725 BG397824

BM801076 BG754924 BG341660 BG341428 BG685992 BX409871 BQ706276 BF975777

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CD19 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:															-																-
SP2:													-		-		-		-												-
SP3:									-		-		-		-
SP4:																																									-
SP5:											-				-

ECgene alternative splicing isoforms for CD19

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAAGATGC

About this image

CD19 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Blood

Blood

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Blood

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Mesenchymal stem cell (Adult Stem / Progenitor Cell)

Bone

Placenta-derived adherent stromal cell (PLX) (Adult Stem / Progenitor Cell)

Extraembryonic Tissues, Placenta

See CD19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD19

SOURCE GeneReport for Unigene cluster: Hs.652262

SABiosciences Expression via Pathway-Focused PCR Arrays including CD19:

Cell Surface Markers in human mouse rat

Stem Cells in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD19 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD19

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CD19 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd19^{1 , 5}	CD19 antigen^{1, 5}	76.53(n)¹ 67.65(a)¹		7 (69.01 cM)⁵ 12478¹ NM_009844.2¹ NP_033974.2¹ 126408450⁵

ENSEMBL Gene Tree for CD19 (if available)
TreeFam Gene Tree for CD19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78332096^1,2	C,F,	--	26810079(+)	`CTACTC/TGCCCC`	2	--	us2k¹		2	WA EA	238
rs45528034^1,2	C,F,	--	26810251(+)	`TGAGAA/GAGTGG`	2	--	us2k¹		1	EA	120
rs35469594^1,2	C	--	26810346(+)	`GAGAGA/CCAGAG`	2	--	us2k¹		1	NA	2
rs75661213^1,2	C,F,	--	26810580(+)	`CTGTGC/TCTGGC`	2	--	us2k¹		1	NA	120
rs77213850^1,2	C,F,	--	26811560(+)	`CCTCTG/TCTCTA`	2	--	int¹		1	WA	118
rs112625011^1,2	C,	--	26811584(+)	`GGAGTC/TGGGGG`	2	--	int¹		1	NA	2
rs111934107^1,2		--	26813485(+)	`ATCTGC/ACTGCC`	2	--	int¹		1	CSA	2
rs113797527^1,2		--	26816322(+)	`CAGGAC/TGCGCC`	4	R C	mis¹		1	CSA	2
rs2904881^1,2	C,H	--	26816745(+)	`CTTCTC/ACACCA`	2	--	int¹ trp³		3	NS NA	124
rs2032907^1,2	H	--	26817272(-)	`CAGGAT/GGGGGG`	2	--	int¹		1	NS	120

HapMap Linkage Disequilibrium report for CD19 (28943260 - 28950668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD19
1 CNV: 3999
Human Gene Mutation Database (HGMD): CD19

Locus Specific Mutation Databases (LSDB): CD19

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD19

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CD19 for disorders           About GeneDecksing

OMIM gene information: 107265
OMIM disorders: 613493
UniProtKB/Swiss-Prot: CD19_HUMAN, P15391

Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called

antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency,

hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The

defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of

circulating B-cells is usually in the normal range, but can be low

20/48 diseases for CD19 (see all 48): About MalaCards

hypersensitivity reaction type ii disease prolymphocytic leukemia t-cell prolymphocytic leukemia common variable immunodeficiency

b cell prolymphocytic leukemia pemphigus foliaceus non-hodgkin lymphoma severe combined immunodeficiency

connective tissue disease leukemia/lymphoma mantle cell lymphoma lymphoblastic leukemia

systemic lupus erythematosus malt lymphoma leukemia/lymphoma, t-cell peripheral t-cell lymphoma

myeloid leukemia lupus erythematosus hodgkin's lymphoma leukemia

10 diseases from the University of Copenhagen DISEASES database for CD19:

Leukemia Lymphoma Multiple myeloma Agammaglobulinemia

Systemic lupus erythematosus Macroglobulinemia Leukopenia Anemia

Lung disease Gastrointestinal system disease

10/11 Novoseek disease relationships for CD19 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	70.4	1	7517719 (1)
leukemia lymphocytic chronic	65.2	1	7691238 (1)
leukemia	58.6	4	1705571 (1), 9684930 (1), 9566763 (1), 8528044 (1)
plasma cell myeloma	56.9	2	12002767 (1), 8639790 (1)
myeloma	53.8	7	10201980 (2), 8639790 (1)
lymphoma	47.4	4	1705571 (1), 1692257 (1), 9566763 (1), 8528044 (1)
b-all	47.1	4	16185473 (2), 16939815 (1)
blast crisis	44.8	1	1518143 (1)
lymphoma non-hodgkins	33	2	1706642 (1), 7517719 (1)
lymphoma b-cell	19.9	1	16506527 (1)

GeneTests: CD19

Common Variable Immune Deficiency

Genetic Association Database (GAD): CD19
Human Genome Epidemiology (HuGE) Navigator: CD19 (15 documents)

Export disorders for CD19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD19 gene, integrated from 9 sources (see all 183):
(articles sorted by number of sources associating them with CD19)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. (PubMed id 12215898)^{1, 2, 4} Kuroki K.... Tokunaga K. (2002)
Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. (PubMed id 1370948)^{1, 2, 9} Zhou L.J.... Tedder T.F. (1992)
An antibody-deficiency syndrome due to mutations in the CD19 gene. (PubMed id 16672701)^{1, 2} van Zelm M.C.... Franco J.L. (2006)
Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis. (PubMed id 15593213)^{1, 4} Tsuchiya N....Sato S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines. (PubMed id 10706702)^{1, 2} Brooks S.R.... Carter R.H. (2000)
The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. (PubMed id 1375324)^{1, 2} Kozmik Z.... Busslinger M. (1992)
Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. (PubMed id 2472450)^{1, 2} Tedder T.F. and Isaacs C.M. (1989)
CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein- Barr virus-related cytoplasmic tail. (PubMed id 2459292)^{1, 2} Stamenkovic I. and Seed B. (1988)
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. (PubMed id 10933394)^{1, 9} Fujimoto M....Tedder T.F. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 930	HGNC: 1633	AceView: CD19	Ensembl:ENSG00000177455	euGenes: HUgn930
ECgene: CD19	Kegg: 930	H-InvDB: CD19

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD19	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD19	Genetics and Cytogenetics in Oncology and Haematology
CD19base	http://bioinf.uta.fi/CD19base/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD19

Intellectual Property for CD19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD19 gene:
Search GeneIP for patents involving CD19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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