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CD19 Gene

protein-coding   GIFtS: 68
GCID: GC16P028943

CD19 Molecule

(Previous name: CD19 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD19 Molecule1 2     T-Cell Surface Antigen Leu-122 3
CD19 Antigen1 3     CVID32 5
Differentiation Antigen CD192 3     B42
B-Lymphocyte Surface Antigen B42 3     B-Lymphocyte Antigen CD192

External Ids:    HGNC: 16331   Entrez Gene: 9302   Ensembl: ENSG000001774557   OMIM: 1072655   UniProtKB: P153913   

Export aliases for CD19 gene to outside databases

Previous GC identifers: GC16U990011 GC16P029266 GC16P028941 GC16P028980 GC16P028850 GC16P026811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD19 Gene:
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability
of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of
low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen
receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CD19 Gene:
CD19 (CD19 molecule) is a protein-coding gene. Diseases associated with CD19 include immunodeficiency, common variable, 3, and primary immunodeficiency disease. GO annotations related to this gene include receptor signaling protein activity.

UniProtKB/Swiss-Prot: CD19_HUMAN, P15391
Function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen
receptor-dependent stimulation

Gene Wiki entry for CD19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD19 gene promoter:
         STAT1   AP-1   ATF-2   STAT1alpha   CRE-BP1   STAT3   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD19 promoter sequence
   Search Chromatin IP Primers for CD19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

CD19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD19 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028943:  view genomic region     (about GC identifiers)

Start:
28,943,260 bp from pter      End:
28,950,668 bp from pter
Size:
7,409 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD19_HUMAN, P15391 (See protein sequence)
Recommended Name: B-lymphocyte antigen CD19 precursor  
Size: 556 amino acids; 61128 Da
Subunit: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV.
Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when
phosphorylated on Tyr-409. Interacts with LYN
Sequence caution: Sequence=AAA35533.1; Type=Frameshift; Positions=396;
Secondary accessions: A0N0P9 F5H635 Q96S68 Q9BRD6
Alternative splicing: 2 isoforms:  P15391-1   P15391-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD19: NX_P15391

Explore proteomics data for CD19 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine
    following B-cell activation. Phosphorylated on tyrosine residues by LYN1
  • Glycosylation2 at Asn86, Asn125, Asn138, Asn181, Asn265
  • Modification sites at PhosphoSitePlus

  • See CD19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171569.1  NP_001761.3  

    ENSEMBL proteins: 
     ENSP00000313419   ENSP00000456201   ENSP00000437940  
    Reactome Protein details: P15391

    CD19 Human Recombinant Protein Products:

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    Novus Biologicals CD19 Proteins
    Novus Biologicals CD19 Lysates
    Sino Biological Recombinant Protein for CD19
    Sino Biological Cell Lysate for CD19
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    Cloud-Clone Corp. Proteins for CD19

    CD19 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD19
    R&D Systems Antibodies for CD19
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    Abcam antibodies for CD19 (Q0KKI6, 652262, P06127, P15391)
    Cloud-Clone Corp. Antibodies for CD19
    ThermoFisher Antibodies for CD19
    LSBio Antibodies in human, mouse, rat for CD19

    CD19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD19
    Cloud-Clone Corp. CLIAs for CD19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P15391

    ProtoNet protein and cluster: P15391

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD19_HUMAN, P15391
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    CD19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD19_HUMAN, P15391
    Function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen
    receptor-dependent stimulation

         Genatlas biochemistry entry for CD19:
    cell differentiation antigen CD19,95kDa,B cell surface membrane protein PAX5 (BSAP) dependent,identified by
    monoclonal antibodies B4,HD37 and others ,linked to the integrin associated CD9,CD81,KAI1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS1373518
    GO:0005515protein binding ----
         
    CD19 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD19:
     Increased S DNA content  Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cd19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  tumorigenesis 

    CD19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd19tm1Tft for CD19

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD19

    miRNA
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    Block miRNA regulation of human, mouse, rat CD19 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD19:
    hsa-miR-3934 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCD19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD19
    Predesigned siRNA for gene silencing in human, mouse, rat CD19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD19

    Clone
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    OriGene clones in human, mouse for CD19 (see all 10)
    OriGene ORF clones in mouse, rat for CD19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD19 (NM_001770)
    Sino Biological Human cDNA Clone for CD19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD19

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD19
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD19_HUMAN, P15391: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2472450
    GO:0009897external side of plasma membrane IDA17213291
    GO:0070062extracellular vesicular exosome IDA--

    CD19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD19 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    3Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    4Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    5CREB Pathway
    IP3 Pathway0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD19
        p70S6K Signaling
    IP3 Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for CD19
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for CD19
        G-protein signaling Regulation of RAC1 activity
    Immune response BCR pathway

    2 BioSystems Pathways for CD19
        B Cell Receptor Signaling Pathway
    BCR signaling pathway


    4 Reactome Pathways for CD19
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Constitutive PI3K/AKT Signaling in Cancer
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
    PIP3 activates AKT signaling


    5 Kegg Pathways  (Kegg details for CD19):
        PI3K-Akt signaling pathway
    Hematopoietic cell lineage
    B cell receptor signaling pathway
    Epstein-Barr virus infection
    Primary immunodeficiency


    CD19 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD19: 
              Cell Surface Markers in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD19 (P153912, 3 ENSP000003134194) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061872, 3, ENSP000003081764MINT-7230949 MINT-7230932 MINT-7230971 I2D: score=3 STRING: ENSP00000308176
    PIK3R1P279862, 3, ENSP000002743354MINT-8028100 MINT-8037707 I2D: score=5 STRING: ENSP00000274335
    ARID3AQ998562, ENSP000002636204MINT-7230949 MINT-7230932 MINT-7230971 STRING: ENSP00000263620
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=3 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=3 STRING: ENSP00000009180
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS1373518
    GO:0007166cell surface receptor signaling pathway TAS1714482
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    CD19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD19

    6 Novoseek inferred chemical compound relationships for CD19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ricin 48.3 2 1370636 (1)
    phosphatidylinositol 40.1 8 9808169 (2), 7688513 (1), 10201980 (1), 9190913 (1) (see all 5)
    tyrosine 27.4 25 9808169 (3), 9200454 (3), 12938232 (2), 10933394 (2) (see all 12)
    doxorubicin 9.47 2 10825443 (1)
    lipid 0 3 9620684 (2), 11713294 (1)
    calcium 0 3 9620684 (1), 11584010 (1)



    CD19 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD19 gene (2 alternative transcripts): 
    NM_001178098.1  NM_001770.5  

    Unigene Cluster for CD19:

    CD19 molecule
    Hs.652262  [show with all ESTs]
    Unigene Representative Sequence: BC052294
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324662 ENST00000565089 ENST00000567541 ENST00000566890 ENST00000567368
    ENST00000538922(uc010byo.2 uc002drs.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CD19:
    hsa-miR-3934 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCD19 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD19 (NM_001770)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD19
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD19
      QuantiTect SYBR Green Assays in human, mouse, rat CD19
      QuantiFast Probe-based Assays in human, mouse, rat CD19

    Additional mRNA sequence: 

    AK130657.1 AK301167.1 AK301363.1 AK304456.1 AK307295.1 AK313577.1 BC006338.2 BC052294.1 
    M21097.1 X13312.1 

    6 DOTS entries:

    DT.454928  DT.99961528  DT.95082330  DT.95268084  DT.91833223  DT.95268082 

    Selected AceView cDNA sequences (see all 58):

    AK130657 AW574858 BQ066405 BX094429 BQ055377 NM_001770 BP340638 BG258419 
    AW402245 BI769680 BP340570 BC006338 BC052294 BQ216515 M21097 BQ063609 
    BQ057181 BG758327 BG342178 BX409871 BF663403 BM801076 BG685992 BQ706276 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD19 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                            -                                               -                                                   
    SP2:                                      -     -     -     -                                   -                                                   
    SP3:                          -     -     -     -                                                                                                   
    SP4:                                                                                                                          -                     
    SP5:                                -           -                                                                                                   


    ECgene alternative splicing isoforms for CD19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAGATGC
    CD19 Expression
    About this image


    CD19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Mature B-Cells Peripheral Blood
             Facilitating cells
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Body Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Wharton's Jelly
             Placenta-derived adherent stromal cell (PLX)
    CD19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652262
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD19: 
              Cell Surface Markers in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD19
    OriGene qSTAR qPCR primer pairs in human, mouse for CD19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD19
    QuantiTect SYBR Green Assays in human, mouse, rat CD19
    QuantiFast Probe-based Assays in human, mouse, rat CD19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD19 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd191 , 5 CD19 antigen1, 5 76.29(n)1
    67.46(a)1
      7 (69.01 cM)5
    124781  NM_009844.21  NP_033974.21 
     1264084505 
    lizard
    (Anolis carolinensis)
    Reptilia CD196
    CD19 molecule
    23(a)
    1 ↔ 1
    GL343287.1(547531-564020)


    ENSEMBL Gene Tree for CD19 (if available)
    TreeFam Gene Tree for CD19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for CD19    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347639451,2,4
    ----see VAR_0369872 mis40--------
    rs29048801,2,4
    ----see VAR_0269632 mis40--------

    HapMap Linkage Disequilibrium report for CD19 (28943260 - 28950668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CD19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518648CNV Loss19592680
    nsv905700CNV Loss21882294
    nsv905701CNV Loss21882294
    nsv519100CNV Gain19592680
    nsv905702CNV Gain+Loss21882294
    dgv842e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD19
    Locus Specific Mutation Databases (LSDB): CD19

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD19
    DNA2.0 Custom Variant and Variant Library Synthesis for CD19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107265   
    OMIM disorders: 613493  
    UniProtKB/Swiss-Prot: CD19_HUMAN, P15391
  • Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by
    antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody
    response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of
    immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for CD19 (see all 60):    
    About MalaCards
    immunodeficiency, common variable, 3    primary immunodeficiency disease    t-cell prolymphocytic leukemia    gastrointestinal system disease
    b cell prolymphocytic leukemia    cd19-related common variable immune deficiency    prolymphocytic leukemia    common variable immune deficiency
    hypersensitivity reaction type ii disease    systemic scleroderma    peripheral t-cell lymphoma    lymphoid leukemia
    immunodeficiency, common variable, 9    leukemia/lymphoma, t-cell    pemphigus foliaceus    myeloma
    b-cell chronic lymphocytic leukemia    agammaglobulinemia    common variable immunodeficiency    chronic lymphocytic leukemia

    13 diseases from the University of Copenhagen DISEASES database for CD19:
    Leukemia     Lymphoma     Agammaglobulinemia     Multiple myeloma
    Hypersensitivity reaction type II disease     Connective tissue disease     Leukopenia     Macroglobulinemia
    Anemia     Lung disease     Rheumatoid arthritis     Thrombocytopenia
    Gastrointestinal system disease

    CD19 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD19 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 70.4 1 7517719 (1)
    leukemia lymphocytic chronic 65.2 1 7691238 (1)
    leukemia 58.6 4 1705571 (1), 9684930 (1), 9566763 (1), 8528044 (1)
    plasma cell myeloma 56.9 2 12002767 (1), 8639790 (1)
    myeloma 53.8 7 10201980 (2), 8639790 (1)
    lymphoma 47.4 4 1705571 (1), 1692257 (1), 9566763 (1), 8528044 (1)
    b-all 47.1 4 16185473 (2), 16939815 (1)
    blast crisis 44.8 1 1518143 (1)
    lymphoma non-hodgkins 33 2 1706642 (1), 7517719 (1)
    lymphoma b-cell 19.9 1 16506527 (1)

    GeneTests: CD19
    GeneReviews: CD19
    Genetic Association Database (GAD): CD19
    Human Genome Epidemiology (HuGE) Navigator: CD19 (15 documents)

    Export disorders for CD19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD19 gene, integrated from 10 sources (see all 187):
    (articles sorted by number of sources associating them with CD19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. (PubMed id 12215898)1, 2, 4 Kuroki K.... Tokunaga K. (Genes Immun. 2002)
    2. Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. (PubMed id 1370948)1, 2, 9 Zhou L.J.... Tedder T.F. (Immunogenetics 1992)
    3. Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (PubMed id 19421221)1, 4 Malheiros D. and Petzl-Erler M.L. (Genes Immun. 2009)
    4. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    5. Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. (PubMed id 17493148)1, 4 Hitomi Y.... Sato S. (Tissue Antigens 2007)
    6. An antibody-deficiency syndrome due to mutations in the CD19 gene. (PubMed id 16672701)1, 2 van Zelm M.C.... Franco J.L. (N. Engl. J. Med. 2006)
    7. Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis. (PubMed id 15593213)1, 4 Tsuchiya N....Sato S. (Arthritis Rheum. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines. (PubMed id 10706702)1, 2 Brooks S.R.... Carter R.H. (J. Immunol. 2000)
    10. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. (PubMed id 1375324)1, 2 Kozmik Z.... Busslinger M. (Mol. Cell. Biol. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 930 HGNC: 1633 AceView: CD19 Ensembl:ENSG00000177455 euGenes: HUgn930
    ECgene: CD19 Kegg: 930 H-InvDB: CD19

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD19 Genetics and Cytogenetics in Oncology and Haematology
    CD19basehttp://bioinf.uta.fi/CD19base/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CD19[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD19 gene:
    Search GeneIP for patents involving CD19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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