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CD180 Gene

protein-coding   GIFtS: 55
GCID: GC05M066514

CD180 Molecule

(Previous names: lymphocyte antigen 64 (mouse) homolog, radioprotective,...)
(Previous symbol: LY64)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD180 Molecule1 2     Radioprotective 105 KDa Protein2 3
LY641 2 3 5     Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD1
CD180 Antigen1 2 3     Ly782
RP1052 3 5     Lymphocyte Antigen-64, Radioprotective, 105kDa2
Lymphocyte Antigen 642 3     

External Ids:    HGNC: 67261   Entrez Gene: 40642   Ensembl: ENSG000001340617   OMIM: 6022265   UniProtKB: Q994673   

Export aliases for CD180 gene to outside databases

Previous GC identifer: GC05M063436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD180 Gene:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic
tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex,
RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in
concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent
of Gram-negative bacteria. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD180 Gene:
CD180 (CD180 molecule) is a protein-coding gene. Diseases associated with CD180 include kawasaki disease, and primary biliary cirrhosis. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide
(LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By
similarity)

Gene Wiki entry for CD180 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD180 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   LUN-1   IRF-1   LCR-F1   RORalpha1   COMP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD180 promoter sequence
   Search Chromatin IP Primers for CD180

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD180


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12

CD180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD180 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M066514:  view genomic region     (about GC identifiers)

Start:
66,478,103 bp from pter      End:
66,492,627 bp from pter
Size:
14,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467 (See protein sequence)
Recommended Name: CD180 antigen precursor  
Size: 661 amino acids; 74179 Da
Subunit: M-shaped tetramer of two CD180-LY86 heterodimers
1 PDB 3D structure from and Proteopedia for CD180:
3B2D (3D)    
Secondary accessions: B2R7Z7 Q32MM5

Explore the universe of human proteins at neXtProt for CD180: NX_Q99467

Explore proteomics data for CD180 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys176
  • Glycosylation2 at Asn34, Asn53, Asn70, Asn78, Asn201, Asn234, Asn244, Asn394, Asn402, Asn451,
                                 Asn573
  • Modification sites at PhosphoSitePlus

  • See CD180 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005573.2  
    ENSEMBL proteins: 
     ENSP00000256447  
    Reactome Protein details: Q99467

    CD180 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CD180
    GenScript Custom Purified and Recombinant Proteins Services for CD180
    Novus Biologicals CD180 Proteins
    Sino Biological Recombinant Protein for CD180
    Sino Biological Cell Lysate for CD180
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD180

    CD180 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD180
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CD180
    OriGene Custom Antibody Services for CD180
    Novus Biologicals CD180 Antibodies
    Abcam antibodies for CD180
    Cloud-Clone Corp. Antibodies for CD180
    ThermoFisher Antibody for CD180
    LSBio Antibodies in human, mouse, rat for CD180

    CD180 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD180
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD180
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD180
    Cloud-Clone Corp. CLIAs for CD180


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q99467

    ProtoNet protein and cluster: Q99467

    1 Blocks protein domain: IPB000483 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    CD180 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD180_HUMAN, Q99467
    Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide
    (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CD180 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd180):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    CD180 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd180tm1Kmiy for CD180

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD180
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD180

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD180
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD180

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD180 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD180
    Predesigned siRNA for gene silencing in human, mouse, rat CD180

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD180

    Clone
    Products:
         
    OriGene clones in human, mouse for CD180 (see all 7)
    OriGene ORF clones in mouse, rat for CD180
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD180 (NM_005582)
    Sino Biological Human cDNA Clone for CD180
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD180
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD180

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD180
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD180 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD180_HUMAN, Q99467: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    CD180 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CD180
        PI3K Signaling in B-Lymphocyte


    1 Reactome Pathway for CD180
        Toll Like Receptor 4 (TLR4) Cascade



    CD180 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD180: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD180

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CD180 (Q994673 ENSP000002564474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LY86O957113, ENSP000002305684I2D: score=7 STRING: ENSP00000230568
    LY96ENSP000002848184STRING: ENSP00000284818
    TLR4ENSP000003630894STRING: ENSP00000363089
    CD14ENSP000003042364STRING: ENSP00000304236
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002322B cell proliferation involved in immune response IEA--
    GO:0006954inflammatory response IEA--
    GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway IGI10880523
    GO:0045087innate immune response IEA--
    GO:0071222cellular response to lipopolysaccharide IEA--

    CD180 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD180

    1 Novoseek inferred chemical compound relationship for CD180 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 35.2 2 17284926 (1), 15852007 (1)



    CD180 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD180 gene: 
    NM_005582.2  

    Unigene Cluster for CD180:

    CD180 molecule
    Hs.87205  [show with all ESTs]
    Unigene Representative Sequence: NM_005582
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256447(uc003juy.2) ENST00000515027
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD180 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD180
    Predesigned siRNA for gene silencing in human, mouse, rat CD180
    Clone
    Products:
         
    OriGene clones in human, mouse for CD180 (see all 7)
    OriGene ORF clones in mouse, rat for CD180
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD180 (NM_005582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD180
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD180
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD180
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD180
      QuantiTect SYBR Green Assays in human, mouse, rat CD180
      QuantiFast Probe-based Assays in human, mouse, rat CD180

    Additional mRNA sequence: 

    AK313177.1 BC109069.1 BC109070.1 D83597.1 

    2 DOTS entries:

    DT.211059  DT.100702082 

    Selected AceView cDNA sequences (see all 41):

    CR601140 AW512119 AA284033 AI342091 BX952485 AL570708 AW135858 AA832186 
    AL544501 NM_005582 BP344300 D83597 AW770071 AA252816 AW408614 BU429708 
    AA252850 BX348277 BI821308 AI368365 BI821331 AI655384 BE504623 AI655114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD180 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGAGTG
    CD180 Expression
    About this image


    CD180 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CD180 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD180 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87205

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix.
    Not detected in pre-B and -T cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD180: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CD180
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD180
    QuantiTect SYBR Green Assays in human, mouse, rat CD180
    QuantiFast Probe-based Assays in human, mouse, rat CD180
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD180 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1801 , 5 CD180 antigen1, 5 78.72(n)1
    73.98(a)1
      13 (54.92 cM)5
    170791  NM_008533.21  NP_032559.21 
     1026935585 
    chicken
    (Gallus gallus)
    Aves CD1801 CD180 molecule 59.95(n)
    53.06(a)
      431584  XM_004937310.1  XP_004937367.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD1806
    CD180 molecule
    47(a)
    1 ↔ 1
    2(11473210-11480052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cd1801 CD180 molecule 50.18(n)
    40.43(a)
      100489673  XM_004921444.1  XP_004921501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018853271 CD180 antigen-like 48.22(n)
    40.14(a)
      101885327  XM_005165669.1  XP_005165726.1 


    ENSEMBL Gene Tree for CD180 (if available)
    TreeFam Gene Tree for CD180 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD180 gene
    ENSG000001733662  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  

    CD180 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD180 (see all 429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145971851,2
    F--66477722(+) ATGCCT/CTCTTC 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1894404211,2
    --66477730(+) TTCCTA/CATTTT 1 -- int10--------
    rs1119779271,2
    C,F--66477761(+) AATGCT/CCTCCG 1 -- int12Minor allele frequency- C:0.08CSA WA 120
    rs47001741,2
    C,F,A,H--66477789(+) AGGGCA/GAGCCT 1 -- int113Minor allele frequency- G:0.24NA NS EA WA CSA 925
    rs168963771,2
    C,F,H--66477852(+) GAACCG/AGATGC 1 -- int127Minor allele frequency- A:0.13NA NS EA WA CSA 2907
    rs1397364951,2
    --66477858(+) GATGCC/TCAAAT 1 -- int10--------
    rs1931782761,2
    C--66477863(+) CCAAAC/TGAGAA 1 -- int10--------
    rs1475998381,2
    C--66477937(+) TAGGC-/AGAGAGA 1 -- int10--------
    rs57445301,2
    C,F,H--66478055(-) TCTGTA/GAGGTC 1 -- int112Minor allele frequency- G:0.03NA EU NS EA CSA WA 1296
    rs1849933981,2
    C--66478133(+) AATTTA/CTTATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD180 (66478103 - 66492627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD180:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6085n71CNV Gain21882294
    dgv1803e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD180
    DNA2.0 Custom Variant and Variant Library Synthesis for CD180

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602226    OMIM disorders: --

    Selected diseases for CD180 (see all 25):    
    About MalaCards
    kawasaki disease    primary biliary cirrhosis    polymyositis    dermatomyositis
    sjogren's syndrome    childhood leukemia    lupus erythematosus    atopic dermatitis
    multiple myeloma    meningioma    dermatitis    periodontitis
    hepatitis c virus    myeloma    chronic lymphocytic leukemia    tonsillitis
    systemic lupus erythematosus    hepatitis c    hepatitis    hepatitis b


    CD180 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CD180 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 18.4 3 10616005 (2), 15742454 (1)

    Genetic Association Database (GAD): CD180
    Human Genome Epidemiology (HuGE) Navigator: CD180 (8 documents)

    Export disorders for CD180 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD180 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with CD180)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PubMed id 8975706)1, 2, 3, 9 Miura Y.... Kimoto M. (Genomics 1996)
    2. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PubMed id 9763566)1, 2, 3, 9 Miura Y.... Kimoto M. (Blood 1998)
    3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    4. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. (PubMed id 21959264)1, 2 Ohto U.... Shimizu T. (J. Mol. Biol. 2011)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4064 HGNC: 6726 AceView: LY64 Ensembl:ENSG00000134061 euGenes: HUgn4064
    ECgene: CD180 H-InvDB: CD180

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD180 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD180 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD180 gene:
    Search GeneIP for patents involving CD180

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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