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Aliases for CD180 Gene

Aliases for CD180 Gene

  • CD180 Molecule 2 3
  • CD180 Antigen 2 3 4
  • RP105 3 4 6
  • LY64 3 4 6
  • Radioprotective 105 KDa Protein 3 4
  • Lymphocyte Antigen 64 3 4
  • Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD 2
  • Lymphocyte Antigen-64, Radioprotective, 105kDa 3
  • Ly78 3

External Ids for CD180 Gene

Previous HGNC Symbols for CD180 Gene

  • LY64

Previous GeneCards Identifiers for CD180 Gene

  • GC05M066514
  • GC05M063436

Summaries for CD180 Gene

Entrez Gene Summary for CD180 Gene

  • CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD180 Gene

CD180 (CD180 Molecule) is a Protein Coding gene. Diseases associated with CD180 include primary biliary cirrhosis. Among its related pathways are IL-2 Pathway. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for CD180 Gene

  • May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Gene Wiki entry for CD180 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD180 Gene

Genomics for CD180 Gene

Genomic Location for CD180 Gene

67,181,377 bp from pter
67,196,799 bp from pter
15,423 bases
Minus strand

Genomic View for CD180 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD180 Gene

Proteins for CD180 Gene

  • Protein details for CD180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD180 antigen
    Protein Accession:
    Secondary Accessions:
    • B2R7Z7
    • Q32MM5

    Protein attributes for CD180 Gene

    661 amino acids
    Molecular mass:
    74179 Da
    Quaternary structure:
    • M-shaped tetramer of two CD180-LY86 heterodimers.

    Three dimensional structures from OCA and Proteopedia for CD180 Gene

neXtProt entry for CD180 Gene

Proteomics data for CD180 Gene at MOPED

Post-translational modifications for CD180 Gene

  • Ubiquitination at Lys176
  • Glycosylation at Asn34, Asn53, Asn70, Asn78, Asn201, Asn234, Asn244, Asn394, Asn402, Asn451, and Asn573
  • Modification sites at PhosphoSitePlus

Other Protein References for CD180 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD180 Gene

Domains for CD180 Gene

Gene Families for CD180 Gene

  • CD :CD molecules

Protein Domains for CD180 Gene

Suggested Antigen Peptide Sequences for CD180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99467
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the Toll-like receptor family.
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CD180: view

Function for CD180 Gene

Molecular function for CD180 Gene

UniProtKB/Swiss-Prot Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Gene Ontology (GO) - Molecular Function for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD180: view
genes like me logo Genes that share phenotypes with CD180: view

Animal Models for CD180 Gene

MGI Knock Outs for CD180:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD180 Gene

Localization for CD180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD180 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD180 Gene COMPARTMENTS Subcellular localization image for CD180 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD180: view

Pathways for CD180 Gene

SuperPathways for CD180 Gene

Superpath Contained pathways
1 IL-2 Pathway
genes like me logo Genes that share pathways with CD180: view

Pathways by source for CD180 Gene

1 Qiagen pathway for CD180 Gene

Gene Ontology (GO) - Biological Process for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002322 B cell proliferation involved in immune response IEA --
GO:0006954 inflammatory response IEA --
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IGI 10880523
GO:0045087 innate immune response IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with CD180: view

Compounds for CD180 Gene

(1) Novoseek inferred chemical compound relationships for CD180 Gene

Compound -log(P) Hits PubMed IDs
endotoxin 35.2 2
genes like me logo Genes that share compounds with CD180: view

Transcripts for CD180 Gene

mRNA/cDNA for CD180 Gene

Unigene Clusters for CD180 Gene

CD180 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD180 Gene

No ASD Table

Relevant External Links for CD180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD180 Gene

mRNA expression in normal human tissues for CD180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD180 Gene

This gene is overexpressed in Spleen (11.4) and Whole Blood (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD180 Gene

SOURCE GeneReport for Unigene cluster for CD180 Gene Hs.87205

mRNA Expression by UniProt/SwissProt for CD180 Gene

Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells
genes like me logo Genes that share expressions with CD180: view

Orthologs for CD180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD180 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD180 35
  • 99.24 (n)
  • 99.09 (a)
CD180 36
  • 99 (a)
(Bos Taurus)
Mammalia CD180 35
  • 84.47 (n)
  • 77.91 (a)
CD180 36
  • 78 (a)
(Canis familiaris)
Mammalia CD180 35
  • 83.61 (n)
  • 77.16 (a)
CD180 36
  • 77 (a)
(Mus musculus)
Mammalia Cd180 35
  • 78.72 (n)
  • 73.98 (a)
Cd180 16
Cd180 36
  • 74 (a)
(Monodelphis domestica)
Mammalia CD180 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CD180 36
  • 38 (a)
(Rattus norvegicus)
Mammalia Cd180 35
  • 79.73 (n)
  • 74.13 (a)
(Gallus gallus)
Aves CD180 35
  • 59.95 (n)
  • 53.06 (a)
CD180 36
  • 48 (a)
(Anolis carolinensis)
Reptilia CD180 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd180 35
  • 50.18 (n)
  • 40.43 (a)
(Danio rerio)
Actinopterygii cd180 36
  • 38 (a)
CD180 (2 of 2) 36
  • 39 (a)
LOC101885327 35
  • 48.22 (n)
  • 40.14 (a)
Species with no ortholog for CD180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD180 Gene

Gene Tree for CD180 (if available)
Gene Tree for CD180 (if available)

Paralogs for CD180 Gene

Paralogs for CD180 Gene

genes like me logo Genes that share paralogs with CD180: view

Variants for CD180 Gene

Sequence variations from dbSNP and Humsavar for CD180 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1428467 -- 67,194,030(+) Ctgaa(A/G)ccacc intron-variant
rs1428468 -- 67,194,149(+) gatga(A/G)tttag intron-variant
rs1428469 -- 67,194,265(+) gaatt(C/T)gccta intron-variant
rs1697143 -- 67,185,241(-) TGCGG(A/C)AGTTC intron-variant
rs1697144 -- 67,184,176(-) CAACG(A/G)TCTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD180 Gene

Variant ID Type Subtype PubMed ID
dgv6085n71 CNV Gain 21882294
dgv1803e1 CNV Complex 17122850

Relevant External Links for CD180 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD180 Gene

Disorders for CD180 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD180 Gene including...

Search for CD180 Gene in MalaCards »

(1) Novoseek inferred disease relationships for CD180 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 18.4 3

Relevant External Links for CD180

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD180: view

No data available for UniProtKB/Swiss-Prot for CD180 Gene

Publications for CD180 Gene

  1. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PMID: 9763566) Miura Y. … Kimoto M. (Blood 1998) 2 3 4 23
  2. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PMID: 8975706) Miura Y. … Kimoto M. (Genomics 1996) 2 3 4 23
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. Potentiation of TLR9 responses for human naA^ve B-cell growth through RP105 signaling. (PMID: 20133206) Yamazaki K. … Agematsu K. (Clin. Immunol. 2010) 3 23
  5. Different expression of CD180, CD284 and CD14 receptors on the CD19+ subpopulation of normal and B-CLL lymphocytes. (PMID: 20430725) Antosz H. … DmoszyA8ska A. (Folia Histochem. Cytobiol. 2009) 3 23

Products for CD180 Gene

Sources for CD180 Gene

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