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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD180 Gene

protein-coding   GIFtS: 52
GCID: GC05M066514

CD180 molecule

(Previous names: lymphocyte antigen 64 (mouse) homolog, radioprotective,...)
(Previous symbol: LY64)
 Explore 19 diseases affiliated with
CD180 via our new
 Human Malady Compendium 
Biological research products
for CD180
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CD180 Molecule1 2     Lymphocyte Antigen 642 3
LY641 2 3 5     Radioprotective 105 KDa Protein2 3
RP1051 2 3 5     Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD1
CD180 Antigen1 2 3     Lymphocyte Antigen-64, Radioprotective, 105kDa2
Ly781 2     

External Ids:    HGNC: 67261   Entrez Gene: 40642   Ensembl: ENSG000001340617   OMIM: 6022265   UniProtKB: Q994673   

Export aliases for CD180 gene to outside databases

Previous GC identifer: GC05M063436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD180:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail.
The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex,
RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in
concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of
Gram-negative bacteria. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS)
in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity)

Gene Wiki entry for CD180


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD180 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   LUN-1   IRF-1   LCR-F1   RORalpha1   COMP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD180 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD180

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD180


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12

CD180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD180 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M066514:  view genomic region     (about GC identifiers)

Start:
66,478,103 bp from pter      End:
66,492,627 bp from pter
Size:
14,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467 (See protein sequence)
Recommended Name: CD180 antigen precursor  
Size: 661 amino acids; 74179 Da
Subunit: M-shaped tetramer of two CD180-LY86 heterodimers
Subcellular location: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for CD180:
3B2D (3D)    
Secondary accessions: B2R7Z7 Q32MM5

Explore the universe of human proteins at neXtProt for CD180: NX_Q99467

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99467

  • CD180 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005573.2  
    ENSEMBL proteins: 
     ENSP00000256447  

    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD180

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    CD180 for ontologies           About GeneDecksing



    CD180 Antibody Products: 
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    Uscn ELISAs and CLIAs for CD180


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CD180 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q99467

    ProtoNet protein and cluster: Q99467

    1 Blocks protein family: IPB000483 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS)
    in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD180 (see all 7)
    OriGene shRNA RFP: CD180
    OriGene siRNA: CD180
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    CD180 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cd180tm1Kmiy for CD180
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd180):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    CD180 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD180

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CD180 (Q994673 ENSP000002564474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LY86O957113, ENSP000002305684I2D: score=7 STRING: ENSP00000230568
    LY96ENSP000002848184STRING: ENSP00000284818
    TLR4ENSP000003630894STRING: ENSP00000363089
    CD14ENSP000003042364STRING: ENSP00000304236
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0045087innate immune response IEA--


    CD180 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD180 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD180
    1 Novoseek chemical compound relationship for CD180 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 35.2 2 17284926 (1), 15852007 (1)

    Search CenterWatch for drugs/clinical trials and news about CD180 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD180 gene: 
    NM_005582.2  

    Unigene Cluster for CD180:

    CD180 molecule
    Hs.87205  [show with all ESTs]
    Unigene Representative Sequence: NM_005582
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256447(uc003juy.2) ENST00000515027

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CD180
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD180
    Clone
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    Additional cDNA sequence: 

    AK313177.1 BC109069.1 BC109070.1 D83597.1 

    2 DOTS entries:

    DT.211059  DT.100702082 

    24/41 AceView cDNA sequences (see all 41):

    BX952485 CR601140 AW135858 AL544501 AA832186 AW512119 AL570708 AI342091 
    AA284033 D83597 AW408614 AI368365 BI821331 BF059629 AI655114 BU429708 
    BQ230992 AA252850 AA252816 BX348277 AI655384 BP344300 BI821308 NM_005582 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD180 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CD180 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD180

    SOURCE GeneReport for Unigene cluster: Hs.87205

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not
    detected in pre-B and -T cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD180: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD180 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1801 , 5 CD180 antigen1, 5 78.72(n)1
    73.98(a)1
      13 (54.92 cM)5
    170791  NM_008533.21  NP_032559.21 
     1026935585 
    chicken
    (Gallus gallus)
    Aves CD1801 CD180 molecule 59.49(n)
    52.63(a)
      431584  XM_003642909.1  XP_003642957.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD1806
    --
    48(a)
    1 ↔ 1
    2(11473210-11475774)
    zebrafish
    (Danio rerio)
    Actinopterygii CR753899.16
    cd1806
    CD180 molecule
    30(a)
    29(a)
    many → 1
    many → 1
    5(55512580-55514561)
    5(55372879-55376720)
    fruit fly
    (Drosophila melanogaster)
    Insecta Tl6
    MstProx6
    (see all 4)
    MstProx
    (see all 4)
    8(a)
    8(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    3R(22624765-22668125)
    3R(3191661-3195027)


    ENSEMBL Gene Tree for CD180 (if available)
    TreeFam Gene Tree for CD180 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD180 gene
    ENSG000001733662  TLR72  TLR12  TLR92  TLR52  TLR102  LRRC332  TLR42  
    TLR82  TLR62  LRRC322  TLR32  TLR22  

    CD180 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/344 NCBI SNPs in CD180 are shown (see all 344    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145971851,2
    --66477722(+) ATGCCT/CTCTTC 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1894404211,2
    --66477730(+) TTCCTA/CATTTT 1 -- int10--------
    rs1119779271,2
    --66477761(+) AATGCT/CCTCCG 1 -- int12Minor allele frequency- C:0.08CSA WA 120
    rs47001741,2
    C,F,A,H,--66477789(+) AGGGCA/GAGCCT 1 -- int113Minor allele frequency- G:0.24NA NS EA WA CSA 925
    rs168963771,2
    C,F,H,--66477852(+) GAACCG/AGATGC 1 -- int127Minor allele frequency- A:0.13NA NS EA WA CSA 2907
    rs1397364951,2
    --66477858(+) GATGCC/TCAAAT 1 -- int10--------
    rs1931782761,2
    --66477863(+) CCAAAC/TGAGAA 1 -- int10--------
    rs1475998381,2
    C,--66477937(+) TAGGC-/AGAGAGA 1 -- int10--------
    rs57445301,2
    C,F,H,--66478055(-) TCTGTA/GAGGTC 1 -- int112Minor allele frequency- G:0.03NA EU NS EA CSA WA 1296
    rs1849933981,2
    --66478133(+) AATTTA/CTTATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD180 (66478103 - 66492627 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CD180
         1 CNV: 3556

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CD180 for disorders           About GeneDecksing

    OMIM gene information: 602226    OMIM disorders: --

    19 diseases for CD180:    About MalaCards
    primary biliary cirrhosis    lupus erythematosus    systemic lupus erythematosus    atopic dermatitis
    chronic lymphocytic leukemia    lymphocytic leukemia    kawasaki disease    sjogren's syndrome
    multiple myeloma    polymyositis    dermatitis    hepatitis c
    dermatomyositis    hepatitis b    myeloma    periodontitis
    meningioma    hepatitis    leukemia

    1 Novoseek disease relationship for CD180 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 18.4 3 10616005 (2), 15742454 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD180 (8 documents)

    Export disorders for CD180 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD180 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CD180)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PubMed id 8975706)1, 2, 3, 9 Miura Y.... Kimoto M. (1996)
    2. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PubMed id 9763566)1, 2, 3, 9 Miura Y.... Kimoto M. (1998)
    3. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. (PubMed id 21959264)1, 2 Ohto U.... Shimizu T. (2011)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Potentiation of TLR9 responses for human naA^ve B-cell growth through RP105 signaling. (PubMed id 20133206)1, 9 Yamazaki K....Agematsu K. (2010)
    7. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. (PubMed id 15852007)1, 9 Divanovic S....Karp C.L. (2005)
    8. Different expression of CD180, CD284 and CD14 recepto rs on the CD19+ subpopulation of normal and B-CLL lymphocytes. (PubMed id 20430725)1, 9 Antosz H....DmoszyA8ska A. (2009)
    9. Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. (PubMed id 17448566)1, 9 Honda Y....Aoyagi Y. (2007)
    10. The anti-inflammatory actions of IL-4 in human monocyt es are not mediated by IL-10, RP105 or the kinase activity of RIPK2. (PubMed id 22484241)1 Woodward E.A....Hart P.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4064 HGNC: 6726 AceView: LY64 Ensembl:ENSG00000134061 euGenes: HUgn4064
    ECgene: CD180 H-InvDB: CD180

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CD180 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD180 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for CD180 gene:
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