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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD180 Gene

protein-coding   GIFtS: 54
GCID: GC05M066514

CD180 Molecule

(Previous names: lymphocyte antigen 64 (mouse) homolog, radioprotective,...)
(Previous symbol: LY64)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD180 Molecule1 2     Radioprotective 105 KDa Protein2 3
LY641 2 3 5     Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD1
CD180 Antigen1 2 3     Ly782
RP1052 3 5     Lymphocyte Antigen-64, Radioprotective, 105kDa2
Lymphocyte Antigen 642 3     

External Ids:    HGNC: 67261   Entrez Gene: 40642   Ensembl: ENSG000001340617   OMIM: 6022265   UniProtKB: Q994673   

Export aliases for CD180 gene to outside databases

Previous GC identifer: GC05M063436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD180 Gene:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic
tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex,
RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in
concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent
of Gram-negative bacteria. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD180 Gene: 
CD180 (CD180 molecule) is a protein-coding gene. Diseases associated with CD180 include kawasaki disease, and primary biliary cirrhosis. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide
(LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By
similarity)

Gene Wiki entry for CD180 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD180 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B2   LUN-1   IRF-1   LCR-F1   RORalpha1   COMP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD180 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD180

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD180


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12

CD180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD180 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M066514:  view genomic region     (about GC identifiers)

Start:
66,478,103 bp from pter      End:
66,492,627 bp from pter
Size:
14,525 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467 (See protein sequence)
Recommended Name: CD180 antigen precursor  
Size: 661 amino acids; 74179 Da
Subunit: M-shaped tetramer of two CD180-LY86 heterodimers
Subcellular location: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for CD180:
3B2D (3D)    
Secondary accessions: B2R7Z7 Q32MM5

Explore the universe of human proteins at neXtProt for CD180: NX_Q99467

Explore proteomics data for CD180 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99467

  • CD180 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD180 Protein Expression
    REFSEQ proteins: NP_005573.2  
    ENSEMBL proteins: 
     ENSP00000256447  

    Human Recombinant Protein Products for CD180: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD180
    GenScript Custom Purified and Recombinant Proteins Services for CD180
    Novus Biologicals CD180 Proteins
    Sino Biological Recombinant Protein for CD180
    Sino Biological Cell Lysate for CD180 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD180 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CD180 for ontologies           About GeneDecksing



    CD180 Antibody Products: 
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    Novus Biologicals CD180 Antibodies
    Abcam antibodies for CD180
    Cloud-Clone Corp. Antibodies for CD180 
    ThermoFisher Antibody for CD180
    LSBio Antibodies in human, mouse, rat for CD180 

    Assay Products for CD180: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD180
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD180 
    Cloud-Clone Corp. CLIAs for CD180


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q99467

    ProtoNet protein and cluster: Q99467

    1 Blocks protein domain: IPB000483 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    CD180 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD180_HUMAN, Q99467
    Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide
    (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CD180 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd180):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    CD180 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd180tm1Kmiy for CD180

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD180 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD180

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD180 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD180 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD180
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD180
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD180

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD180
    Sirion Biotech Customized adenovirus for overexpression of CD180

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD180 (see all 5)
    OriGene ORF clones in mouse, rat for CD180
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD180 (NM_005582)
    Sino Biological Human cDNA Clone for CD180
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD180
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD180
    Sirion Biotech Customized lentivirus for stable overexpression of CD180 
                         Customized lentivirus expression plasmids for stable overexpression of CD180 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD180
    Search LifeMap BioReagents cell lines for CD180
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD180

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CD180 (Q994673 ENSP000002564474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LY86O957113, ENSP000002305684I2D: score=7 STRING: ENSP00000230568
    LY96ENSP000002848184STRING: ENSP00000284818
    TLR4ENSP000003630894STRING: ENSP00000363089
    CD14ENSP000003042364STRING: ENSP00000304236
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002322B cell proliferation involved in immune response IEA--
    GO:0006954inflammatory response IEA--
    GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway IGI10880523
    GO:0045087innate immune response IEA--
    GO:0071222cellular response to lipopolysaccharide IEA--

    CD180 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD180 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD180

    1 Novoseek inferred chemical compound relationship for CD180 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 35.2 2 17284926 (1), 15852007 (1)

    Search CenterWatch for drugs/clinical trials and news about CD180

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD180 gene: 
    NM_005582.2  

    Unigene Cluster for CD180:

    CD180 molecule
    Hs.87205  [show with all ESTs]
    Unigene Representative Sequence: NM_005582
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256447(uc003juy.2) ENST00000515027
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD180
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD180:
    hsa-miR-875-3p hsa-miR-589 hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidCD180 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD180
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD180
    Clone
    Products:
         
    OriGene clones in human, mouse for CD180 (see all 5)
    OriGene ORF clones in mouse, rat for CD180
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD180 (NM_005582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD180
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD180
    Sirion Biotech Customized lentivirus for stable overexpression of CD180 
                         Customized lentivirus expression plasmids for stable overexpression of CD180 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CD180
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD180
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD180
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD180

    Additional mRNA sequence: 

    AK313177.1 BC109069.1 BC109070.1 D83597.1 

    2 DOTS entries:

    DT.211059  DT.100702082 

    24/41 AceView cDNA sequences (see all 41):

    AA832186 AW512119 AI342091 AL544501 BX952485 AL570708 AW135858 CR601140 
    AA284033 BX348277 NM_005582 BP344300 AW408614 AA252816 BI821308 BE504623 
    BI821331 AA252850 AW770071 AI655384 BF059629 BU429708 BQ230992 D83597 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD180 expression in normal human tissues (normalized intensities)      CD180 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGAGTG
    CD180 Expression
    About this image


    CD180 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 5 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             b cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose

    See CD180 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD180

    SOURCE GeneReport for Unigene cluster: Hs.87205

    UniProtKB/Swiss-Prot: CD180_HUMAN, Q99467
    Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix.
    Not detected in pre-B and -T cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD180: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD180
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD180

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD180 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1801 , 5 CD180 antigen1, 5 78.72(n)1
    73.98(a)1
      13 (54.92 cM)5
    170791  NM_008533.21  NP_032559.21 
     1026935585 
    chicken
    (Gallus gallus)
    Aves CD1801 CD180 molecule 59.49(n)
    52.63(a)
      431584  XM_003642909.1  XP_003642957.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD1806
    CD180 molecule
    47(a)
    1 ↔ 1
    2(11473210-11480052)
    zebrafish
    (Danio rerio)
    Actinopterygii CD180 (1 of 2)6
    cd1806
    CD180 molecule
    38(a)
    37(a)
    many → 1
    many → 1
    5(55512580-55514561)
    5(55372879-55376720)


    ENSEMBL Gene Tree for CD180 (if available)
    TreeFam Gene Tree for CD180 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD180 gene
    ENSG000001733662  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  

    CD180 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/429 SNPs in CD180 are shown (see all 429)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145971851,2
    F--66477722(+) ATGCCT/CTCTTC 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1894404211,2
    --66477730(+) TTCCTA/CATTTT 1 -- int10--------
    rs1119779271,2
    C,F--66477761(+) AATGCT/CCTCCG 1 -- int12Minor allele frequency- C:0.08CSA WA 120
    rs47001741,2
    C,F,A,H--66477789(+) AGGGCA/GAGCCT 1 -- int113Minor allele frequency- G:0.24NA NS EA WA CSA 925
    rs168963771,2
    C,F,H--66477852(+) GAACCG/AGATGC 1 -- int127Minor allele frequency- A:0.13NA NS EA WA CSA 2907
    rs1397364951,2
    --66477858(+) GATGCC/TCAAAT 1 -- int10--------
    rs1931782761,2
    C--66477863(+) CCAAAC/TGAGAA 1 -- int10--------
    rs1475998381,2
    C--66477937(+) TAGGC-/AGAGAGA 1 -- int10--------
    rs57445301,2
    C,F,H--66478055(-) TCTGTA/GAGGTC 1 -- int112Minor allele frequency- G:0.03NA EU NS EA CSA WA 1296
    rs1849933981,2
    C--66478133(+) AATTTA/CTTATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD180 (66478103 - 66492627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD180:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6085n71CNV Gain21882294
    dgv1803e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD180
    DNA2.0 Custom Variant and Variant Library Synthesis for CD180

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602226    OMIM disorders: --

    19 diseases for CD180:    About MalaCards
    kawasaki disease    primary biliary cirrhosis    polymyositis    dermatomyositis
    sjogren's syndrome    atopic dermatitis    lupus erythematosus    multiple myeloma
    chronic lymphocytic leukemia    meningioma    dermatitis    myeloma
    periodontitis    systemic lupus erythematosus    hepatitis c    hepatitis b
    hepatitis    leukemia    endotheliitis


    CD180 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CD180 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 18.4 3 10616005 (2), 15742454 (1)

    Genetic Association Database (GAD): CD180
    Human Genome Epidemiology (HuGE) Navigator: CD180 (8 documents)

    Export disorders for CD180 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD180 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with CD180)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PubMed id 8975706)1, 2, 3, 9 Miura Y.... Kimoto M. (1996)
    2. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PubMed id 9763566)1, 2, 3, 9 Miura Y.... Kimoto M. (1998)
    3. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    4. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. (PubMed id 21959264)1, 2 Ohto U.... Shimizu T. (2011)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4064 HGNC: 6726 AceView: LY64 Ensembl:ENSG00000134061 euGenes: HUgn4064
    ECgene: CD180 H-InvDB: CD180

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD180 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD180 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD180 gene:
    Search GeneIP for patents involving CD180

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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