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Aliases for CD180 Gene

Aliases for CD180 Gene

  • CD180 Molecule 2 3 5
  • Radioprotective 105 KDa Protein 3 4
  • Lymphocyte Antigen 64 3 4
  • CD180 Antigen 2 4
  • RP105 3 4
  • LY64 3 4
  • Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD 2
  • Lymphocyte Antigen-64, Radioprotective, 105kDa 3
  • Ly78 3

External Ids for CD180 Gene

Previous HGNC Symbols for CD180 Gene

  • LY64

Previous GeneCards Identifiers for CD180 Gene

  • GC05M066514
  • GC05M063436

Summaries for CD180 Gene

Entrez Gene Summary for CD180 Gene

  • CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD180 Gene

CD180 (CD180 Molecule) is a Protein Coding gene. Among its related pathways are Immune System and IL-2 Pathway. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for CD180 Gene

  • May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Gene Wiki entry for CD180 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD180 Gene

Genomics for CD180 Gene

Regulatory Elements for CD180 Gene

Promoters for CD180 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD180 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD180 Gene

Chromosome:
5
Start:
67,179,613 bp from pter
End:
67,196,799 bp from pter
Size:
17,187 bases
Orientation:
Minus strand

Genomic View for CD180 Gene

Genes around CD180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD180 Gene

Proteins for CD180 Gene

  • Protein details for CD180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99467-CD180_HUMAN
    Recommended name:
    CD180 antigen
    Protein Accession:
    Q99467
    Secondary Accessions:
    • B2R7Z7
    • Q32MM5

    Protein attributes for CD180 Gene

    Size:
    661 amino acids
    Molecular mass:
    74179 Da
    Quaternary structure:
    • M-shaped tetramer of two CD180-LY86 heterodimers.

    Three dimensional structures from OCA and Proteopedia for CD180 Gene

neXtProt entry for CD180 Gene

Proteomics data for CD180 Gene at MOPED

Post-translational modifications for CD180 Gene

  • Ubiquitination at Lys 176
  • Glycosylation at Asn 34, Asn 53, Asn 70, Asn 78, Asn 201, Asn 234, Asn 244, Asn 394, Asn 402, Asn 451, and Asn 573
  • Modification sites at PhosphoSitePlus

Other Protein References for CD180 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD180 Gene

Domains & Families for CD180 Gene

Gene Families for CD180 Gene

Protein Domains for CD180 Gene

Suggested Antigen Peptide Sequences for CD180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99467

UniProtKB/Swiss-Prot:

CD180_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Toll-like receptor family.
  • Contains 19 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CD180: view

Function for CD180 Gene

Molecular function for CD180 Gene

UniProtKB/Swiss-Prot Function:
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
genes like me logo Genes that share phenotypes with CD180: view

Animal Models for CD180 Gene

MGI Knock Outs for CD180:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD180 Gene

Localization for CD180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD180 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD180 Gene COMPARTMENTS Subcellular localization image for CD180 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD180: view

Pathways & Interactions for CD180 Gene

genes like me logo Genes that share pathways with CD180: view

Pathways by source for CD180 Gene

Gene Ontology (GO) - Biological Process for CD180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway IBA --
GO:0006954 inflammatory response IEA,IBA --
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA,IGI 10880523
genes like me logo Genes that share ontologies with CD180: view

No data available for SIGNOR curated interactions for CD180 Gene

Drugs & Compounds for CD180 Gene

(1) Additional Compounds for CD180 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD180: view

Transcripts for CD180 Gene

mRNA/cDNA for CD180 Gene

Unigene Clusters for CD180 Gene

CD180 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD180 Gene

No ASD Table

Relevant External Links for CD180 Gene

GeneLoc Exon Structure for
CD180
ECgene alternative splicing isoforms for
CD180

Expression for CD180 Gene

mRNA expression in normal human tissues for CD180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD180 Gene

This gene is overexpressed in Spleen (x11.4) and Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for CD180 Gene

This gene is overexpressed in Blymphocyte (24.0), Monocytes (19.8), and Lymph node (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD180 Gene



SOURCE GeneReport for Unigene cluster for CD180 Gene Hs.87205

mRNA Expression by UniProt/SwissProt for CD180 Gene

Q99467-CD180_HUMAN
Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
genes like me logo Genes that share expression patterns with CD180: view

Protein tissue co-expression partners for CD180 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD180 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD180 35
  • 84.47 (n)
  • 77.91 (a)
CD180 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD180 35
  • 83.61 (n)
  • 77.16 (a)
CD180 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd180 35
  • 78.72 (n)
  • 73.98 (a)
Cd180 16
Cd180 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD180 35
  • 99.24 (n)
  • 99.09 (a)
CD180 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd180 35
  • 79.73 (n)
  • 74.13 (a)
oppossum
(Monodelphis domestica)
Mammalia CD180 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD180 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD180 35
  • 59.95 (n)
  • 53.06 (a)
CD180 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD180 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd180 35
  • 50.18 (n)
  • 40.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885327 35
  • 48.22 (n)
  • 40.14 (a)
cd180 36
  • 38 (a)
OneToMany
CD180 (2 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for CD180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD180 Gene

ENSEMBL:
Gene Tree for CD180 (if available)
TreeFam:
Gene Tree for CD180 (if available)

Paralogs for CD180 Gene

Paralogs for CD180 Gene

genes like me logo Genes that share paralogs with CD180: view

Variants for CD180 Gene

Sequence variations from dbSNP and Humsavar for CD180 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs16875312 - 67,185,949(+) CCAAA(C/G)ACAAC reference, missense
rs2230520 - 67,184,546(-) CAAAG(C/G)CATCA reference, missense
rs5744463 - 67,196,584(-) GTAAA(C/G)TCATC reference, missense, utr-variant-5-prime
rs5744525 - 67,184,068(-) ACATT(A/G)ATGAC reference, missense
rs2230523 - 67,183,555(-) CATTT(A/G)CCCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD180 Gene

Variant ID Type Subtype PubMed ID
dgv6085n71 CNV Gain 21882294
dgv1803e1 CNV Complex 17122850

Variation tolerance for CD180 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD180 Gene

HapMap Linkage Disequilibrium report
CD180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD180 Gene

Disorders for CD180 Gene

Relevant External Links for CD180

Genetic Association Database (GAD)
CD180
Human Genome Epidemiology (HuGE) Navigator
CD180
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD180

No disorders were found for CD180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD180 Gene

Publications for CD180 Gene

  1. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). (PMID: 8975706) Miura Y. … Kimoto M. (Genomics 1996) 2 3 4 23 67
  2. RP105 is associated with MD-1 and transmits an activation signal in human B cells. (PMID: 9763566) Miura Y. … Kimoto M. (Blood 1998) 2 3 23
  3. Potentiation of TLR9 responses for human naA^ve B-cell growth through RP105 signaling. (PMID: 20133206) Yamazaki K. … Agematsu K. (Clin. Immunol. 2010) 3 23
  4. Different expression of CD180, CD284 and CD14 receptors on the CD19+ subpopulation of normal and B-CLL lymphocytes. (PMID: 20430725) Antosz H. … DmoszyA8ska A. (Folia Histochem. Cytobiol. 2009) 3 23
  5. Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. (PMID: 17448566) Honda Y. … Aoyagi Y. (J. Hepatol. 2007) 3 23

Products for CD180 Gene

Sources for CD180 Gene

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