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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD177 Gene

protein-coding   GIFtS: 56
GCID: GC19P043857

CD177 molecule

(Previous name: CD177 antigen )
 Explore 15 diseases affiliated with
CD177 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD177    

Aliases
for CD177 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD177 Molecule1 2     HNA-2a2 3
NB11 2 3 5     PRV-12 3
PRV11 2 3 5     NB1 Glycoprotein2 3
CD177 Antigen1 2 3     NB1 GP2 3
HNA2A1 2 5     Cell Surface Receptor2
Human Neutrophil Alloantigen 2a2 3     Polycythemia Rubra Vera 12
Polycythemia Rubra Vera Protein 12 3     

External Ids:    HGNC: 300721   Entrez Gene: 571262   Ensembl: ENSG000002049367   OMIM: 1628605   UniProtKB: Q8N6Q33   

Export aliases for CD177 gene to outside databases

Previous GC identifers: GC19P048550 GC19P040287


Summaries
for CD177 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD177:
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a
case of neonatal alloimmune neutropenia (Lalezari et al., 1971 (PubMed 5552408)).(supplied by OMIM, Mar 2008)

Gene Wiki entry for CD177


Genomic Views
for CD177 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD177 gene promoter:
         ER-alpha   GATA-3   Roaz   C/EBPalpha   YY1   AREB6   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD177 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD177

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD177


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

CD177 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD177 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P043857:  view genomic region     (about GC identifiers)

Start:
 43,857,825 bp from pter      End:
 43,867,480 bp from pter
Size:
 9,656 bases      Orientation:
 plus strand

Proteins
for CD177 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3 (See protein sequence)
Recommended Name: CD177 antigen precursor  
Size: 437 amino acids; 46363 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Mass spectrometry: Mass=50556; Method=MALDI; Range=22-408; Source=PubMed:11465086;
Secondary accessions: Q711Q2 Q8NCV9 Q96QH1 Q9HDA5
Alternative splicing: 3 isoforms:  Q8N6Q3-1   Q8N6Q3-2   Q8N6Q3-3   (Associated with CD177-negative phenotype)

Explore the universe of human proteins at neXtProt for CD177: NX_Q8N6Q3

Post-translational modifications:

  • N-glycosylated1
  • A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N6Q3

    • CD177 Protein expression data from MOPED and PaxDb:    About this image 
    CD177 Protein Expression
    REFSEQ proteins: NP_065139.2  
    ENSEMBL proteins: 
     ENSP00000367248   ENSP00000367251   ENSP00000388794  
    Reactome Protein details: Q8N6Q3
    Human Recombinant Protein Products for CD177: 
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    OriGene Purified Protein: CD177
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    OriGene Custom Protein Services for CD177 
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    Novus Biologicals CD177 Proteins
    Novus Biologicals CD177 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD177

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0031225anchored to membrane IEA--

    CD177 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CD177

    Protein Domains /
    Families
    for CD177 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD177 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001526 LY6_UPAR

    Graphical View of Domain Structure for InterPro Entry Q8N6Q3

    ProtoNet protein and cluster: Q8N6Q3

    1 Blocks protein family: IPB001526 CD59 antigen

    UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3
    Similarity: Contains 2 UPAR/Ly6 domains


    Function
    for CD177 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD177_HUMAN, Q8N6Q3
    Induction: By CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential
    thrombocythemia (ET)

    Animal Models:

       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD177 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD177
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD177:
    hsa-miR-361-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: CD177 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD177 (see all 3)
    OriGene shRNA RFP: CD177
    OriGene siRNA: CD177
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CD177 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD177
    Sirion Biotech Customized adenovirus for overexpression of CD177 
    Sirion Biotech Customized adenovirus for potent knockdown of CD177

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD177 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD177 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD177
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    Sirion Biotech Customized inducible overexpressing cell line services for CD177

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177


    Pathways & Interactions
    for CD177 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell surface interactions at the vascular wall
    		Cell surface interactions at the vascular wall1.00
    2Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CD177
        Hemostasis
    Cell surface interactions at the vascular wall



    CD177 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD177

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for CD177 (Q8N6Q32, 3 ENSP000003887944) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNIP3Q9Y2W72, 3, ENSP000002952254MINT-68147 I2D: score=5 STRING: ENSP00000295225
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    --Q9BWA23, 2MINT-67003 I2D: score=1 
    --Q9BWA23, 2MINT-67003 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--

    CD177 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD177 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD177 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD177
    1 Novoseek chemical compound relationship for CD177 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 1.38 1 16197445 (1)

    Search CenterWatch for drugs/clinical trials and news about CD177 

    Transcripts
    for CD177 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD177 gene: 
    NM_020406.2  

    Unigene Cluster for CD177:

    CD177 molecule
    Hs.232165  [show with all ESTs]
    Unigene Representative Sequence: NM_020406
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378009(uc002owi.3 uc010eis.3 uc002owj.3) ENST00000378012(uc021uvf.1)
    ENST00000457794

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD177
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD177:
    hsa-miR-361-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: CD177 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD177 (see all 3)
    OriGene shRNA RFP: CD177
    OriGene siRNA: CD177
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD177
    Sirion Biotech Custom design and validation of potent shRNA sequences against CD177 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD177
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD177
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD177
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD177

    Additional cDNA sequence: 

    AB237911.1 AF146747.1 AJ290452.1 AJ305326.1 AJ310433.1 AK225226.1 AK290965.1 AM884905.1 
    AY358932.1 BC029167.1 BT020111.1 

    5 DOTS entries:

    DT.70105042  DT.101978348  DT.101956007  DT.100744899  DT.121498649 

    24/66 AceView cDNA sequences (see all 66):

    CD514938 CR592446 AI205247 CF135065 CR608112 AI953910 AI810763 AA570662 
    BQ008250 NM_020406 AL571249 BX371592 BX102247 BQ894891 BX644504 BI758869 
    BC029167 AF146747 BF511324 AJ305326 AA531401 AI673571 AJ310433 AI983325 

    GeneLoc Exon Structure


    Expression
    for CD177 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD177 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CD177 Expression
    About this image

    CD177 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CD177 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD177

    SOURCE GeneReport for Unigene cluster: Hs.232165

    UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3
    Tissue specificity: Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on
    neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET)

        SABiosciences Custom PCR Arrays for CD177
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177

    Orthologs
    for CD177 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for CD177 (if available)
    TreeFam Gene Tree for CD177 (if available) 

    Paralogs
    for CD177 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD177 gene
    CD177P12  TEX1012  LYPD42  
    4 SIMAP similar genes for CD177 using alignment to 4 protein entries:     CD177_HUMAN (see all proteins):
    CD177P1    TEX101    LYPD4    SMR

    CD177 for paralogs           About GeneDecksing



    Genomic Variants
    for CD177 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3
    Polymorphism: There is a significant association between the variants Ala-3, Leu-251 and Thr-348 and a low expression
    of CD177 on neutrophils


    10/217 NCBI SNPs in CD177 are shown (see all 217)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2014767441,2
    		--43855898(+) TTGTA-/TTTTTT 1 -- us2k10--------
    rs1473287171,2
    		--43855938(+) TGTCCA/TGGTTG 1 -- us2k10--------
    rs1487886171,2
    		--43856019(+) TCACCA/GCTCCC 1 -- us2k10--------
    rs1806814131,2
    		--43856098(+) AAACCC/TTGTCT 1 -- us2k10--------
    rs1424167521,2
    		--43856149(+) ACCTGC/TAGTCC 1 -- us2k10--------
    rs1859811351,2
    		--43856163(+) TTACTC/TGGGAG 1 -- us2k10--------
    rs1165464311,2
    		F--43856255(+) CAGCAT/CAGGTG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs722964221,2
    		C--43856280(+) TTTCT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1508728941,2
    		--43856405(+) CAAAGA/GCAAAT 1 -- us2k10--------
    rs1177613791,2
    		--43856410(+) ACAAAT/CAAAGA 1 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for CD177 (43857825 - 43867480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CD177
         4 CNVs: 9309 2244 4082 3192
         1 Inversion: 59894
    Human Gene Mutation Database (HGMD): CD177

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD177
    DNA2.0 Custom Variant and Variant Library Synthesis for CD177

    Disorders / Diseases
    for CD177 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD177 for disorders           About GeneDecksing

    OMIM gene information: 162860    OMIM disorders: --

    15 diseases for CD177:    About MalaCards
    polycythemia    neutropenia    polycythemia vera    wegener's granulomatosis
    myeloproliferative disorder    erythrocytosis    essential thrombocythemia    thrombocytosis
    chronic myeloproliferative disease    myelofibrosis    myelodysplastic syndrome    thrombosis
    kidney disease    vasculitis    prostatitis

    6 diseases from the University of Copenhagen DISEASES database for CD177:
    Polycythemia     Thrombocytosis     Neuroblastoma     Neutropenia
    Myelofibrosis     Hemorrhagic thrombocythemia

    10/18 Novoseek disease relationships for CD177 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycythemia vera 93.6 47 12239154 (6), 16533288 (2), 12730106 (2), 15194544 (2) (see all 27)
    thrombocythemia essential 91.9 16 15951300 (2), 16502591 (2), 15034760 (1), 17976520 (1) (see all 13)
    neutropenia immune 90.5 6 12010833 (1), 11465086 (1), 12623849 (1), 11380420 (1)
    myeloproliferative disorders 87.2 18 17032591 (2), 15749675 (2), 17976520 (1), 14617008 (1) (see all 14)
    polycythemia 86.8 38 14617008 (3), 19999391 (3), 16197445 (3), 15238147 (3) (see all 20)
    erythrocytosis 83.8 9 12893745 (2), 17852451 (2), 17032591 (1), 12430925 (1) (see all 7)
    idiopathic myelofibrosis 83.8 3 17852451 (1), 12377969 (1)
    thrombocytosis 82.1 11 19999391 (3), 17032591 (1), 12515724 (1), 12730106 (1) (see all 9)
    agnogenic myeloid metaplasia 72.5 1 16197445 (1)
    transfusion reaction 68 6 17898576 (2), 11465086 (1), 12623849 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD177 (2 documents)

    Export disorders for CD177 gene to outside databases

    Publications
    for CD177 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD177 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with CD177)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (PubMed id 10753836)1, 2, 3, 9 Temerinac S.... Pahl H.L. (2000)
    2. CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression. (PubMed id 14692971)1, 2, 9 Caruccio L.... Stroncek D. (2004)
    3. Molecular basis of NB1 (HNA-2a, CD177) deficiency. (PubMed id 12010833)1, 2, 9 Kissel K.... Bux J. (2002)
    4. Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. (PubMed id 12239154)1, 2, 9 Klippel S.... Pahl H.L. (2002)
    5. Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms. (PubMed id 12623849)1, 2, 9 Wolff J.... Bux J. (2003)
    6. Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia. (PubMed id 12377969)1, 2, 9 Teofili L.... Larocca L.M. (2002)
    7. Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immunenneutropenia and transfusion reactions. (PubMed id 11465086)1, 2, 9 Kissel K.... Bux J. (2001)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    External Searches for CD177 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CD177 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57126 HGNC: 30072 AceView: PRV1 Ensembl:ENSG00000204936 euGenes: HUgn57126
    ECgene: CD177 H-InvDB: CD177

    Other Databases showing CD177 gene

    (According to HUGE)
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    Specialized Databases showing CD177 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD177 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD177 gene

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    Search GeneIP for patents involving CD177

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