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CD177 Gene

protein-coding   GIFtS: 58
GCID: GC19P043857

CD177 Molecule

(Previous name: CD177 antigen)
  See related diseases
at
MalaCards
 

Aliases
for CD177 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD177 Molecule1 2     HNA-2a2 3
CD177 Antigen1 2 3     PRV-12 3
NB12 3 5     NB1 Glycoprotein2 3
PRV12 3 5     NB1 GP2 3
Polycythemia Rubra Vera 11 2     HNA2A2 5
Human Neutrophil Alloantigen 2a2 3     Cell Surface Receptor2
Polycythemia Rubra Vera Protein 12 3     

External Ids:    HGNC: 300721   Entrez Gene: 571262   Ensembl: ENSG000002049367   OMIM: 1628605   UniProtKB: Q8N6Q33   

Export aliases for CD177 gene to outside databases

Previous GC identifers: GC19P048550 GC19P040287


Summaries
for CD177 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD177 Gene:
NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in
a case of neonatal alloimmune neutropenia (Lalezari et al., 1971 (PubMed 5552408)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CD177 Gene:
CD177 (CD177 molecule) is a protein-coding gene. Diseases associated with CD177 include polycythemia, and hemorrhagic thrombocythemia. An important paralog of this gene is LYPD4.

Gene Wiki entry for CD177 Gene


Genomic Views
for CD177 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD177 gene promoter:
         ER-alpha   GATA-3   Roaz   C/EBPalpha   YY1   AREB6   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD177 promoter sequence
   Search Chromatin IP Primers for CD177

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD177


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

CD177 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD177 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P043857:  view genomic region     (about GC identifiers)

Start:
 43,857,811 bp from pter      End:
 43,867,480 bp from pter
Size:
 9,670 bases      Orientation:
 plus strand

Proteins
for CD177 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3 (See protein sequence)
Recommended Name: CD177 antigen precursor  
Size: 437 amino acids; 46363 Da
Mass spectrometry: Mass=50556; Method=MALDI; Range=22-408; Source=PubMed:11465086;
Secondary accessions: Q711Q2 Q8NCV9 Q96QH1 Q9HDA5
Alternative splicing: 3 isoforms:  Q8N6Q3-1   Q8N6Q3-2   Q8N6Q3-3   (Associated with CD177-negative phenotype)

Explore the universe of human proteins at neXtProt for CD177: NX_Q8N6Q3

Explore proteomics data for CD177 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding)1
  • Glycosylation2 at Asn189

    • See CD177 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065139.2  
    ENSEMBL proteins: 
     ENSP00000475577   ENSP00000388794   ENSP00000367248   ENSP00000367251  
    Reactome Protein details: Q8N6Q3

    CD177 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD177
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    OriGene Purified Proteins for CD177
    OriGene Protein Over-expression Lysate for CD177
    OriGene MassSpec for CD177
    OriGene Custom Protein Services for CD177
    GenScript Custom Purified and Recombinant Proteins Services for CD177
    Novus Biologicals CD177 Proteins
    Novus Biologicals CD177 Lysates
    Sino Biological Recombinant Protein for CD177
    Sino Biological Cell Lysate for CD177
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD177 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD177
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    OriGene Custom Antibody Services for CD177
    Novus Biologicals CD177 Antibodies
    Abcam antibodies for CD177
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD177
    LSBio Antibodies in human, mouse, rat for CD177

    CD177 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD177
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD177
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for CD177 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR001526 LY6_UPAR

    Graphical View of Domain Structure for InterPro Entry Q8N6Q3

    ProtoNet protein and cluster: Q8N6Q3

    1 Blocks protein domain: IPB001526 CD59 antigen

    UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3
    Similarity: Contains 2 UPAR/Ly6 domains


    CD177 for domains           About GeneDecksing


    Function
    for CD177 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD177_HUMAN, Q8N6Q3
    Induction: By CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential
    thrombocythemia (ET)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD177
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD177

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD177
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD177

    miRNA
    Products:            		miRTarBase miRNAs that target CD177:
    hsa-mir-335-5p (MIRT018643)

    Block miRNA regulation of human, mouse, rat CD177 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD177:
    hsa-miR-361-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: CD177 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for CD177
    Predesigned siRNA for gene silencing in human, mouse, rat CD177

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD177

    Clone
    Products:             		 OriGene clones in human, mouse for CD177 (see all 6)
    OriGene ORF clones in mouse, rat for CD177
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD177 (NM_020406)
    Sino Biological Human cDNA Clone for CD177
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD177
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD177

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD177
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD177 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177


    Localization
    for CD177 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD177_HUMAN, Q8N6Q3: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0031225anchored component of membrane IEA--

    CD177 for ontologies           About GeneDecksing


    Pathways & Interactions
    for CD177 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD177 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    		Hemostasis0.43
    2Cell surface interactions at the vascular wall
    		Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD177
        Cell surface interactions at the vascular wall



    CD177 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD177
    Interactions:

        GeneGlobe Interaction Network for CD177

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for CD177 (Q8N6Q32, 3 ENSP000003887944) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNIP3Q9Y2W72, 3, ENSP000002952254MINT-68147 I2D: score=5 STRING: ENSP00000295225
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    --Q9BWA23, 2MINT-67003 I2D: score=1 
    --Q9BWA23, 2MINT-67003 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--

    CD177 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD177 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD177

    1 Novoseek inferred chemical compound relationship for CD177 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 1.38 1 16197445 (1)



    CD177 for compounds           About GeneDecksing



    Transcripts
    for CD177 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD177 gene: 
    NM_020406.2  

    Unigene Cluster for CD177:

    CD177 molecule
    Hs.232165  [show with all ESTs]
    Unigene Representative Sequence: NM_020406
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607517 ENST00000607855 ENST00000457794 ENST00000378009(uc002owi.3 uc010eis.3 uc002owj.3)
    ENST00000378012(uc021uvf.1)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat CD177 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD177:
    hsa-miR-361-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: CD177 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for CD177
    Predesigned siRNA for gene silencing in human, mouse, rat CD177
    Clone
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    OriGene ORF clones in mouse, rat for CD177
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD177 (NM_020406)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD177
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD177
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for CD177
    OriGene qSTAR qPCR primer pairs in human, mouse for CD177
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD177
      QuantiTect SYBR Green Assays in human, mouse, rat CD177
      QuantiFast Probe-based Assays in human, mouse, rat CD177

    Additional mRNA sequence: 

    AB237911.1 AF146747.1 AJ290452.1 AJ305326.1 AJ310433.1 AK225226.1 AK290965.1 AM884905.1 
    AY358932.1 BC029167.1 BT020111.1 

    5 DOTS entries:

    DT.70105042  DT.101978348  DT.101956007  DT.100744899  DT.121498649 

    Selected AceView cDNA sequences (see all 66):

    CR592446 AI953910 BQ008250 CD514938 CF135065 AI205247 AI810763 AA570662 
    CR608112 BX644504 BC029167 AF146747 AI983325 AA531401 AL571249 AW236210 
    AL543254 CD630132 BI758869 AY358932 NM_020406 AJ290452 BF511324 BQ894891 

    GeneLoc Exon Structure


    Expression
    for CD177 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD177 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD177 Expression
    About this image


    CD177 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Prostate (Endocrine System)
    CD177 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    CD177 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232165

    UniProtKB/Swiss-Prot: CD177_HUMAN, Q8N6Q3
    Tissue specificity: Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on
    neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia
    (ET)

        Custom PCR Arrays for CD177
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CD177
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177

    Orthologs
    for CD177 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD177 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd1771 , 5 CD177 antigen1, 5 62.26(n)1
    54.57(a)1    		   7 (12.58 cM)5
    688911  NM_026862.31  NP_081138.21 
     247439855 


    ENSEMBL Gene Tree for CD177 (if available)
    TreeFam Gene Tree for CD177 (if available)

    Paralogs
    for CD177 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD177 gene
    LYPD42  TEX1012  
    2 SIMAP similar genes for CD177 using alignment to 4 protein entries:     CD177_HUMAN (see all proteins):
    TEX101    LYPD4

    CD177 for paralogs           About GeneDecksing



    Genomic Variants
    for CD177 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CD177_HUMAN, Q8N6Q3: There is a significant association between the variants Ala-3, Leu-251 and Thr-348 and a low
    expression of CD177 on neutrophils


    Selected SNPs for CD177 (see all 299)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2014767441,2
    		--43855898(+) TTGTA-/TTTTTT 1 -- us2k10--------
    rs1473287171,2
    		C--43855938(+) TGTCCA/TGGTTG 1 -- us2k10--------
    rs1487886171,2
    		--43856019(+) TCACCA/GCTCCC 1 -- us2k10--------
    rs1806814131,2
    		--43856098(+) AAACCC/TTGTCT 1 -- us2k10--------
    rs1424167521,2
    		C--43856149(+) ACCTGC/TAGTCC 1 -- us2k10--------
    rs1859811351,2
    		--43856163(+) TTACTC/TGGGAG 1 -- us2k10--------
    rs1165464311,2
    		C,F--43856255(+) CAGCAT/CAGGTG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs722964221,2
    		C--43856280(+) TTTCT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1508728941,2
    		C--43856405(+) CAAAGA/GCAAAT 1 -- us2k10--------
    rs1177613791,2
    		C,F--43856410(+) ACAAAT/CAAAGA 1 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for CD177 (43857811 - 43867480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CD177 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469787CNV Loss16826518
    esv2751795CNV Loss17911159
    nsv526966CNV Loss19592680
    nsv828561CNV Loss20364138
    nsv828560CNV Gain20364138
    nsv516973CNV Gain+Loss19592680
    essv21588CNV CNV17122850
    essv22369CNV CNV17122850
    nsv469666CNV Complex16826518
    dgv1087e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD177
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD177
    DNA2.0 Custom Variant and Variant Library Synthesis for CD177

    Disorders / Diseases
    for CD177 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162860    OMIM disorders: --

    19 diseases for CD177:    
    About MalaCards
    polycythemia    hemorrhagic thrombocythemia    essential thrombocythemia    thrombocytosis
    polycythemia vera    neutropenia    chronic myeloproliferative disease    erythrocytosis
    myelofibrosis    myeloproliferative disorder    wegener's granulomatosis    myelodysplastic syndromes
    vasculitis    kidney disease    myeloid leukemia    endotheliitis
    neuroblastoma    leukemia    prostatitis

    6 diseases from the University of Copenhagen DISEASES database for CD177:
    Polycythemia     Thrombocytosis     Neutropenia     Neuroblastoma
    Myelofibrosis     Hemorrhagic thrombocythemia

    CD177 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD177 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycythemia vera 93.6 47 12239154 (6), 16533288 (2), 12730106 (2), 15194544 (2) (see all 27)
    thrombocythemia essential 91.9 16 15951300 (2), 16502591 (2), 15034760 (1), 17976520 (1) (see all 13)
    neutropenia immune 90.5 6 12010833 (1), 11465086 (1), 12623849 (1), 11380420 (1)
    myeloproliferative disorders 87.2 18 17032591 (2), 15749675 (2), 17976520 (1), 14617008 (1) (see all 14)
    polycythemia 86.8 38 14617008 (3), 19999391 (3), 16197445 (3), 15238147 (3) (see all 20)
    erythrocytosis 83.8 9 12893745 (2), 17852451 (2), 17032591 (1), 12430925 (1) (see all 7)
    idiopathic myelofibrosis 83.8 3 17852451 (1), 12377969 (1)
    thrombocytosis 82.1 11 19999391 (3), 17032591 (1), 12515724 (1), 12730106 (1) (see all 9)
    agnogenic myeloid metaplasia 72.5 1 16197445 (1)
    transfusion reaction 68 6 17898576 (2), 11465086 (1), 12623849 (1)

    Genetic Association Database (GAD): CD177
    Human Genome Epidemiology (HuGE) Navigator: CD177 (2 documents)

    Export disorders for CD177 gene to outside databases

    Publications
    for CD177 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD177 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with CD177)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (PubMed id 10753836)1, 2, 3, 9 Temerinac S.... Pahl H.L. (Blood 2000)
    2. Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms. (PubMed id 12623849)1, 2, 4, 9 Wolff J.... Bux J. (Blood 2003)
    3. CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression. (PubMed id 14692971)1, 2, 9 Caruccio L.... Stroncek D. (Transfusion 2004)
    4. Molecular basis of NB1 (HNA-2a, CD177) deficiency. (PubMed id 12010833)1, 2, 9 Kissel K.... Bux J. (Blood 2002)
    5. Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. (PubMed id 12239154)1, 2, 9 Klippel S.... Pahl H.L. (Blood 2002)
    6. Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia. (PubMed id 12377969)1, 2, 9 Teofili L.... Larocca L.M. (J. Clin. Oncol. 2002)
    7. Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immunenneutropenia and transfusion reactions. (PubMed id 11465086)1, 2, 9 Kissel K.... Bux J. (Eur. J. Immunol. 2001)
    8. Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2. (PubMed id 19695014)1, 4 Moritz E....Bordin J.O. (Vox Sang. 2010)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    External Searches for CD177 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CD177 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57126 HGNC: 30072 AceView: PRV1 Ensembl:ENSG00000204936 euGenes: HUgn57126
    ECgene: CD177 H-InvDB: CD177

    Other Databases showing CD177 gene

    (According to HUGE)
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    Specialized Databases showing CD177 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD177 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD177 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for CD177 gene:
    Search GeneIP for patents involving CD177

    GeneCards and IP:
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    Products
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