CD177 Gene

Aliases
for CD177 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC19P048550 GC19P040287

Summaries
for CD177 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for CD177 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011109.17  

SwitchGear Promoter luciferase reporter plasmid: CD177 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD177

CD177 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P043857:  view genomic region     (about GC identifiers)

Proteins
for CD177 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for CD177: NX_Q8N6Q3

Explore proteomics data for CD177 at MOPED

Post-translational modifications: 

CD177 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD177
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for CD177 OriGene Protein Over-expression Lysate for CD177 OriGene MassSpec for CD177 OriGene Custom Protein Services for CD177
	GenScript Custom Purified and Recombinant Proteins Services for CD177
	Novus Biologicals CD177 Proteins Novus Biologicals CD177 Lysates
	Sino Biological Recombinant Protein for CD177 Sino Biological Cell Lysate for CD177
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CD177
	Search GeneTex for Proteins for CD177
	antibodies-online proteins for CD177 (9 products)
	Search antibodies-online for peptides for CD177

CD177 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD177
	OriGene Antibodies for CD177 OriGene Custom Antibody Services for CD177
	Novus Biologicals CD177 Antibodies
	Abcam antibodies for CD177
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CD177
	antibodies-online antibodies for CD177 (64 products)

CD177 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CD177
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD177
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CD177
	antibodies-online kits for CD177 (4 products)

Domains /
Families
for CD177 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q8N6Q3

Find genes that share domains with CD177           About GenesLikeMe

Function
for CD177 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CD177

miRNA Products:		miRTarBase miRNAs that target CD177: hsa-mir-335-5p (MIRT018643)
		Block miRNA regulation of human, mouse, rat CD177 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate CD177:
		hsa-miR-361-5p hsa-miR-4257
		SwitchGear 3'UTR luciferase reporter plasmid: CD177 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD177
		Predesigned siRNA for gene silencing in human, mouse, rat CD177

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD177

Clone Products:		OriGene clones in human, mouse for CD177 (see all 6) OriGene ORF clones in mouse, rat for CD177 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD177 (NM_020406)
		Sino Biological Human cDNA Clone for CD177
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD177
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD177

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD177
		Browse ESI BIO Cell Lines and PureStem Progenitors for CD177

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177

Localization
for CD177 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
extracellular	3
nucleus	1

About this image

Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CD177 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CD177 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Hemostasis	Hemostasis 0.43
2	Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall

1 Reactome Pathway for CD177

Cell surface interactions at the vascular wall

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for CD177 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for CD177 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for CD177 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD177 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

NULL (Uncategorized)
Definitive endoderm-like cells
Bone (Muscoskeletal System)
Bone Marrow
Colon (Gastrointestinal Tract)
Prostate (Endocrine System)

Primer Products:		OriGene qPCR primer pairs and template standards for CD177 OriGene qSTAR qPCR primer pairs in human, mouse for CD177
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD177
		QuantiTect SYBR Green Assays in human, mouse, rat CD177
		QuantiFast Probe-based Assays in human, mouse, rat CD177

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD177

Orthologs
for CD177 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for CD177 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for CD177 gene

LYPD4²  TEX101²  

2 SIMAP similar genes for CD177 using alignment to 4 protein entries:     CD177_HUMAN (see all proteins):

TEX101    LYPD4

Find genes that share paralogs with CD177           About GenesLikeMe

Genomic Variants
for CD177 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for CD177 (see all 299)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs2014767441,2		--	43855898(+)	TTGTA-/TTTTTT	1	--	us2k1		0	--	--	--	--
rs1473287171,2	C	--	43855938(+)	TGTCCA/TGGTTG	1	--	us2k1		0	--	--	--	--
rs1487886171,2		--	43856019(+)	TCACCA/GCTCCC	1	--	us2k1		0	--	--	--	--
rs1806814131,2		--	43856098(+)	AAACCC/TTGTCT	1	--	us2k1		0	--	--	--	--
rs1424167521,2	C	--	43856149(+)	ACCTGC/TAGTCC	1	--	us2k1		0	--	--	--	--
rs1859811351,2		--	43856163(+)	TTACTC/TGGGAG	1	--	us2k1		0	--	--	--	--
rs1165464311,2	C,F	--	43856255(+)	CAGCAT/CAGGTG	1	--	us2k1		1		WA	118
rs722964221,2	C	--	43856280(+)	TTTCT-/AAAAAA	1	--	us2k1		1		CSA	2
rs1508728941,2	C	--	43856405(+)	CAAAGA/GCAAAT	1	--	us2k1		0	--	--	--	--
rs1177613791,2	C,F	--	43856410(+)	ACAAAT/CAAAGA	1	--	us2k1		1		NA	120

HapMap Linkage Disequilibrium report for CD177 (43857811 - 43867480 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CD177 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv469787	CNV	Loss	16826518
esv2751795	CNV	Loss	17911159
nsv526966	CNV	Loss	19592680
nsv828561	CNV	Loss	20364138
nsv828560	CNV	Gain	20364138
nsv516973	CNV	Gain+Loss	19592680
essv21588	CNV	CNV	17122850
essv22369	CNV	CNV	17122850
nsv469666	CNV	Complex	16826518
dgv1087e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): CD177

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CD177

DNA2.0 Custom Variant and Variant Library Synthesis for CD177

Disorders / Diseases
for CD177 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

10 diseases for CD177

Selected Novoseek inferred disease relationships for CD177 gene (see all 18)    About this table

Publications
for CD177 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (PubMed id 10753836)^{1, 2, 3, 9} Temerinac S.... Pahl H.L. (Blood 2000)
2. Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms. (PubMed id 12623849)^{1, 2, 4, 9} Wolff J.... Bux J. (Blood 2003)
3. CD177 polymorphisms: correlation between high-frequency single nucleotide polymorphisms and neutrophil surface protein expression. (PubMed id 14692971)^{1, 2, 9} Caruccio L.... Stroncek D. (Transfusion 2004)
4. Molecular basis of NB1 (HNA-2a, CD177) deficiency. (PubMed id 12010833)^{1, 2, 9} Kissel K.... Bux J. (Blood 2002)
5. Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera. (PubMed id 12239154)^{1, 2, 9} Klippel S.... Pahl H.L. (Blood 2002)
6. Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia. (PubMed id 12377969)^{1, 2, 9} Teofili L.... Larocca L.M. (J. Clin. Oncol. 2002)
7. Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immunenneutropenia and transfusion reactions. (PubMed id 11465086)^{1, 2, 9} Kissel K.... Bux J. (Eur. J. Immunol. 2001)
8. Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2. (PubMed id 19695014)^{1, 4} Moritz E....Bordin J.O. (Vox Sang. 2010)
9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (Protein Sci. 2004)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

External Searches for CD177 gene

Genome Databases showing CD177 gene

Other Databases showing CD177 gene

Specialized Databases showing CD177 gene

Products
for CD177 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section