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CD177 Gene(Protein Coding)

CD177 Molecule

GCID:
GC19P043353
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CD177 Gene

Aliases for CD177 Gene

  • CD177 Molecule 2 3 5
  • Polycythemia Rubra Vera Protein 1 3 4
  • Human Neutrophil Alloantigen 2a 3 4
  • NB1 Glycoprotein 3 4
  • CD177 Antigen 2 4
  • NB1 GP 3 4
  • HNA-2a 3 4
  • PRV-1 3 4
  • PRV1 3 4
  • NB1 3 4
  • Polycythemia Rubra Vera 1 2
  • Cell Surface Receptor 3
  • HNA2A 3

External Ids for CD177 Gene

Previous GeneCards Identifiers for CD177 Gene

  • GC19P048550
  • GC19P043857
  • GC19P040287

Summaries for CD177 Gene

Entrez Gene Summary for CD177 Gene

  • This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

GeneCards Summary for CD177 Gene

CD177 (CD177 Molecule) is a Protein Coding gene. Diseases associated with CD177 include Polycythemia and Essential Thrombocythemia. Among its related pathways are Platelet activation, signaling and aggregation and Cell surface interactions at the vascular wall. An important paralog of this gene is LYPD4.

Gene Wiki entry for CD177 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD177 Gene

Genomics for CD177 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CD177 Gene

Enhancers for CD177 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD177 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD177 gene promoter:

Genomic Location for CD177 Gene

Chromosome:
19
Start:
43,353,659 bp from pter
End:
43,363,172 bp from pter
Size:
9,514 bases
Orientation:
Plus strand

Genomic View for CD177 Gene

Genes around CD177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD177 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD177 Gene

Proteins for CD177 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6Q3-CD177_HUMAN
    Recommended name:
    CD177 antigen
    Protein Accession:
    Q8N6Q3
    Secondary Accessions:
    • Q711Q2
    • Q8NCV9
    • Q96QH1
    • Q9HDA5

    Protein attributes for CD177 Gene

    Size:
    437 amino acids
    Molecular mass:
    46363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD177 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD177 Gene

Proteomics data for CD177 Gene at MOPED

Protein Expression for CD177 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD177 Gene

Other Protein References for CD177 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CD177
  • Cloud-Clone Corp. Antibodies for CD177

No data available for DME Specific Peptides for CD177 Gene

Domains & Families for CD177 Gene

Gene Families for CD177 Gene

HGNC:

Protein Domains for CD177 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6Q3

UniProtKB/Swiss-Prot:

CD177_HUMAN :
  • Contains 2 UPAR/Ly6 domains.
Domain:
  • Contains 2 UPAR/Ly6 domains.
genes like me logo Genes that share domains with CD177: view

Function for CD177 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CD177 Gene

UniProtKB/Swiss-Prot Induction:
By CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET).

Phenotypes for CD177 Gene

MGI mutant phenotypes for CD177:
inferred from 1 alleles
GenomeRNAi human phenotypes for CD177:
genes like me logo Genes that share phenotypes with CD177: view

Animal Models for CD177 Gene

MGI Knock Outs for CD177:

Animal Model Products

miRNA for CD177 Gene

miRTarBase miRNAs that target CD177

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD177 Gene

Localization for CD177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD177 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD177 Gene COMPARTMENTS Subcellular localization image for CD177 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CD177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CD177: view

Pathways & Interactions for CD177 Gene

genes like me logo Genes that share pathways with CD177: view

Interacting Proteins for CD177 Gene

Selected Interacting proteins: Q8N6Q3-CD177_HUMAN for CD177 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for CD177 Gene

None

No data available for SIGNOR curated interactions for CD177 Gene

Drugs & Compounds for CD177 Gene

Products:

  1. Drug

(1) Drugs for CD177 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CD177: view

Transcripts for CD177 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CD177 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD177 Gene

CD177 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD177 Gene

No ASD Table

Relevant External Links for CD177 Gene

GeneLoc Exon Structure for
CD177
ECgene alternative splicing isoforms for
CD177

Expression for CD177 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CD177 Gene

mRNA expression in normal human tissues for CD177 Gene
mRNA expression by BioGPS for CD177 GenemRNA expression by GTEx for CD177 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD177 Gene

This gene is overexpressed in Whole Blood (x47.7).

Protein differential expression in normal tissues from HIPED for CD177 Gene

This gene is overexpressed in Nasal epithelium (45.5), Cervix (6.9), and Saliva (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD177 Gene



SOURCE GeneReport for Unigene cluster for CD177 Gene Hs.232165

mRNA Expression by UniProt/SwissProt for CD177 Gene

Q8N6Q3-CD177_HUMAN
Tissue specificity: Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET).
genes like me logo Genes that share expression patterns with CD177: view

Primer Products

No data available for Protein tissue co-expression partners for CD177 Gene

Orthologs for CD177 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD177 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia LOC612424 35
  • 68.7 (n)
  • 58.02 (a)
CD177 36
  • 18 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cd177 35
  • 62.26 (n)
  • 54.57 (a)
Cd177 16
Cd177 36
  • 9 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CD177 35
  • 96.17 (n)
  • 93.39 (a)
CD177 36
  • 65 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cd177 35
  • 64.03 (n)
  • 53.58 (a)
cow
(Bos Taurus)
 Mammalia CD177 36
  • 16 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 26 (a)
 OneToMany
Species with no ortholog for CD177:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD177 Gene

ENSEMBL:
Gene Tree for CD177 (if available)
TreeFam:
Gene Tree for CD177 (if available)

Paralogs for CD177 Gene

Paralogs for CD177 Gene

(2) SIMAP similar genes for CD177 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD177: view

Variants for CD177 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD177 Gene

CD177_HUMAN-Q8N6Q3
There is a significant association between the variants Ala-3, Leu-251 and Thr-348 and a low expression of CD177 on neutrophils.

Sequence variations from dbSNP and Humsavar for CD177 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs45441892 - 43,353,721(+) TGAGC(A/C/G)CGGTA reference, missense
rs10425835 - 43,360,396(+) TGCTC(A/C/G)TAGAT reference, missense
VAR_025860 -
VAR_026156 -
VAR_026157 -

Structural Variations from Database of Genomic Variants (DGV) for CD177 Gene

Variant ID Type Subtype PubMed ID
dgv1087e1 CNV Complex 17122850
nsv516973 CNV Gain+Loss 19592680
esv2751795 CNV Loss 17911159
essv22369 CNV CNV 17122850
nsv469787 CNV Loss 16826518
essv21588 CNV CNV 17122850
nsv469666 CNV Complex 16826518
nsv526966 CNV Loss 19592680
esv5616 OTHER Inversion 19470904
nsv828560 CNV Gain 20364138
nsv828561 CNV Loss 20364138
esv8862 OTHER Inversion 19470904

Variation tolerance for CD177 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD177 Gene

Human Gene Mutation Database (HGMD)
CD177

Disorders for CD177 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CD177 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycythemia
  • erythrocythemia
essential thrombocythemia
  • hemorrhagic thrombocythemia
myelofibrosis
  • agnogenic myeloid metaplasia
deep leiomyoma
polycythemia vera, somatic
  • primary polycythemia
- elite association - COSMIC cancer census association via MalaCards
Search CD177 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD177

Genetic Association Database (GAD)
CD177
Human Genome Epidemiology (HuGE) Navigator
CD177
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD177
genes like me logo Genes that share disorders with CD177: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD177 Gene

Publications for CD177 Gene

  1. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. (PMID: 10753836) Temerinac S. … Pahl H.L. (Blood 2000) 2 3 4 23 67
  2. JAK2 V617F mutation and PRV-1 overexpression: relevance in the diagnosis of polycythaemia vera and essential thrombocythaemia. (PMID: 19999391) Melis S. … De Schouwer P.J. (Acta Clin Belg 2009) 3 23
  3. Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines. (PMID: 17980909) Dillon M. … Lannutti B.J. (Leuk. Res. 2008) 3 23
  4. Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177. (PMID: 17898576) Stroncek D.F. (Curr. Opin. Hematol. 2007) 3 23
  5. Epigenetic control of PRV-1 expression on neutrophils. (PMID: 17976520) Jelinek J. … Afshar-Kharghan V. (Exp. Hematol. 2007) 3 23

Products for CD177 Gene

Sources for CD177 Gene

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