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Aliases for CD164L2 Gene

Aliases for CD164L2 Gene

  • CD164 Molecule Like 2 2 3 5
  • CD164 Sialomucin-Like 2 Protein 3
  • CD164 Sialomucin-Like 2 2
  • EAPG6122 3
  • UNQ6122 3

External Ids for CD164L2 Gene

Previous GeneCards Identifiers for CD164L2 Gene

  • GC01M027578
  • GC01M027705
  • GC01M025961

Summaries for CD164L2 Gene

GeneCards Summary for CD164L2 Gene

CD164L2 (CD164 Molecule Like 2) is a Protein Coding gene. An important paralog of this gene is CD164.

Additional gene information for CD164L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD164L2 Gene

Genomics for CD164L2 Gene

GeneHancer (GH) Regulatory Elements for CD164L2 Gene

Promoters and enhancers for CD164L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I027382 Promoter/Enhancer 1.1 EPDnew Ensembl 569 +0.0 2 1.3 KLF1 PKNOX1 SP3 NRF1 BCL11B HIC1 SP1 POLR2A KLF9 ZNF24 CD164L2 FCN3
GH01I027391 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.9 -10.2 -10169 5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 GPR3 CD164L2 EYA3 GPATCH3 ARID1A DNAJC8 PHACTR4 PIR34425 GC01M027441
GH01I027487 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.5 -107.3 -107316 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MCM3 WASF2 ARID1A ACTG1P20 GPN2 FAM76A PHACTR4 NPM1P39 MAP3K6 ENSG00000231344 LOC101928728
GH01I027425 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -49.4 -49402 13.6 HDGF PKNOX1 ATF1 FOXA2 ARNT ETS1 TCF12 ZNF766 E2F8 ARID2 ACTG1P20 CD164L2 WASF2 FGR LOC105376892 ARID1A FAM76A RNU6-48P TMEM222 PHACTR4
GH01I027516 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -140.4 -140433 13.7 ZFP64 DMAP1 YY1 ZNF548 ZNF263 MCM3 SP3 MEF2D SSRP1 GLIS1 LOC105376892 ARID1A ACTG1P20 MAP3K6 FAM76A PHACTR4 NPM1P39 EYA3 WASF2 GPN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD164L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD164L2 gene promoter:

Genomic Locations for CD164L2 Gene

Genomic Locations for CD164L2 Gene
4,281 bases
Minus strand

Genomic View for CD164L2 Gene

Genes around CD164L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD164L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD164L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD164L2 Gene

Proteins for CD164L2 Gene

  • Protein details for CD164L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD164 sialomucin-like 2 protein
    Protein Accession:
    Secondary Accessions:
    • B2RPJ0
    • Q5JXD6

    Protein attributes for CD164L2 Gene

    174 amino acids
    Molecular mass:
    18534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD164L2 Gene


neXtProt entry for CD164L2 Gene

Post-translational modifications for CD164L2 Gene

  • Glycosylation at Asn71, posLast=103103, and Thr116

Other Protein References for CD164L2 Gene

No data available for DME Specific Peptides for CD164L2 Gene

Domains & Families for CD164L2 Gene

Gene Families for CD164L2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CD164L2 Gene


Suggested Antigen Peptide Sequences for CD164L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD164 family.
  • Belongs to the CD164 family.
genes like me logo Genes that share domains with CD164L2: view

Function for CD164L2 Gene

Phenotypes From GWAS Catalog for CD164L2 Gene

genes like me logo Genes that share phenotypes with CD164L2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD164L2 Gene

Localization for CD164L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD164L2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD164L2 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD164L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IBA --
genes like me logo Genes that share ontologies with CD164L2: view

Pathways & Interactions for CD164L2 Gene

SuperPathways for CD164L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD164L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CD164L2 Gene

Drugs & Compounds for CD164L2 Gene

No Compound Related Data Available

Transcripts for CD164L2 Gene

mRNA/cDNA for CD164L2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD164L2 Gene

CD164 sialomucin-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD164L2 Gene

No ASD Table

Relevant External Links for CD164L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD164L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD164L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD164L2 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9), Skin - Sun Exposed (Lower leg) (x6.3), Vagina (x5.3), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CD164L2 Gene:


SOURCE GeneReport for Unigene cluster for CD164L2 Gene:

genes like me logo Genes that share expression patterns with CD164L2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD164L2 Gene

Orthologs for CD164L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD164L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD164L2 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia CD164L2 33 34
  • 87.28 (n)
(Rattus norvegicus)
Mammalia LOC100359977 33
  • 82.07 (n)
(Mus musculus)
Mammalia Cd164l2 33 16 34
  • 80.9 (n)
(Bos Taurus)
Mammalia CD164L2 34
  • 66 (a)
(Monodelphis domestica)
Mammalia CD164L2 34
  • 54 (a)
(Danio rerio)
Actinopterygii cd164l2 33 34
  • 50.14 (n)
Species where no ortholog for CD164L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD164L2 Gene

Gene Tree for CD164L2 (if available)
Gene Tree for CD164L2 (if available)

Paralogs for CD164L2 Gene

Paralogs for CD164L2 Gene

(1) SIMAP similar genes for CD164L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD164L2: view

Variants for CD164L2 Gene

Sequence variations from dbSNP and Humsavar for CD164L2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000690253 -- 27,381,640(-) C/A intron_variant
rs1001135366 -- 27,384,185(-) A/T upstream_transcript_variant
rs1002194981 -- 27,385,119(-) T/G upstream_transcript_variant
rs1002272046 -- 27,378,751(-) G/A downstream_transcript_variant
rs1002323172 -- 27,383,019(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD164L2 Gene

Variant ID Type Subtype PubMed ID
esv1006916 CNV deletion 20482838
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for CD164L2 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD164L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD164L2 Gene

Disorders for CD164L2 Gene

Additional Disease Information for CD164L2

No disorders were found for CD164L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD164L2 Gene

Publications for CD164L2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CD164L2 Gene

Sources for CD164L2 Gene

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