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Aliases for CD164L2 Gene

Aliases for CD164L2 Gene

  • CD164 Molecule Like 2 2 3 5
  • CD164 Sialomucin-Like 2 Protein 3
  • CD164 Sialomucin-Like 2 2
  • EAPG6122 3
  • UNQ6122 3

External Ids for CD164L2 Gene

Previous GeneCards Identifiers for CD164L2 Gene

  • GC01M027578
  • GC01M027705
  • GC01M025961

Summaries for CD164L2 Gene

GeneCards Summary for CD164L2 Gene

CD164L2 (CD164 Molecule Like 2) is a Protein Coding gene. An important paralog of this gene is CD164.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD164L2 Gene

Genomics for CD164L2 Gene

Regulatory Elements for CD164L2 Gene

Enhancers for CD164L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F027398 1.2 Ensembl ENCODE 21.1 -19.9 -19931 9.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CD164L2 NPM1P39 WASF2 ENSG00000243659 ACTG1P20 RNU6-48P TMEM222 MAP3K6 HMGN2 GC01M027432
GH01F027391 1 Ensembl ENCODE 20.9 -10.2 -10236 5.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 CD164L2 GPR3 GC01M027432 PIR34425
GH01F027425 1.4 FANTOM5 Ensembl ENCODE 20.5 -49.4 -49403 13.6 HDGF PKNOX1 ARNT ETS1 KLF7 KLF13 NCOA1 REST SMARCA4 PBX2 ACTG1P20 CD164L2 WASF2 FGR LOC105376892 RNU6-48P TMEM222 PHACTR4 PPP1R8 RNU6-1245P
GH01F027445 1.3 Ensembl ENCODE 20.2 -62.1 -62121 1.0 HDGF MXI1 SIN3A BMI1 EBF1 ZNF2 ZBTB40 RELA ZNF121 CREM CD164L2 LOC105376892 WASF2 ACTG1P20 RNU6-48P TMEM222 ENSG00000241169 PIR40118
GH01F027471 0.2 Ensembl 20 -90.7 -90721 5.4 SCRT1 KLF1 TFAP4 HLF JUNB EBF1 ZKSCAN1 ZNF121 ZFHX2 ZNF316 CD164L2 LOC105376892 WASF2 ENSG00000241169
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD164L2 on UCSC Golden Path with GeneCards custom track

Promoters for CD164L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001743065 80 201 KLF1 SP3 NRF1 ZBTB7A SP1 POLR2A KLF9 IRF1 HMGN3 KLF8

Genomic Location for CD164L2 Gene

Chromosome:
1
Start:
27,379,100 bp from pter
End:
27,383,380 bp from pter
Size:
4,281 bases
Orientation:
Minus strand

Genomic View for CD164L2 Gene

Genes around CD164L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD164L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD164L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD164L2 Gene

Proteins for CD164L2 Gene

  • Protein details for CD164L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWJ8-C16L2_HUMAN
    Recommended name:
    CD164 sialomucin-like 2 protein
    Protein Accession:
    Q6UWJ8
    Secondary Accessions:
    • B2RPJ0
    • Q5JXD6

    Protein attributes for CD164L2 Gene

    Size:
    174 amino acids
    Molecular mass:
    18534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD164L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD164L2 Gene

Post-translational modifications for CD164L2 Gene

  • Glycosylation at Asn 71, Asn 103, and Thr 116
  • Modification sites at PhosphoSitePlus

Other Protein References for CD164L2 Gene

No data available for DME Specific Peptides for CD164L2 Gene

Domains & Families for CD164L2 Gene

Protein Domains for CD164L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD164L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWJ8

UniProtKB/Swiss-Prot:

C16L2_HUMAN :
  • Belongs to the CD164 family.
Family:
  • Belongs to the CD164 family.
genes like me logo Genes that share domains with CD164L2: view

No data available for Gene Families for CD164L2 Gene

Function for CD164L2 Gene

genes like me logo Genes that share phenotypes with CD164L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD164L2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD164L2 Gene

Localization for CD164L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD164L2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD164L2 Gene COMPARTMENTS Subcellular localization image for CD164L2 gene
Compartment Confidence
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CD164L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD164L2: view

Pathways & Interactions for CD164L2 Gene

SuperPathways for CD164L2 Gene

No Data Available

Interacting Proteins for CD164L2 Gene

Selected Interacting proteins: Q6UWJ8-C16L2_HUMAN for CD164L2 Gene via IID

Gene Ontology (GO) - Biological Process for CD164L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CD164L2 Gene

Transcripts for CD164L2 Gene

mRNA/cDNA for CD164L2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD164L2 Gene

CD164 sialomucin-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD164L2 Gene

No ASD Table

Relevant External Links for CD164L2 Gene

GeneLoc Exon Structure for
CD164L2
ECgene alternative splicing isoforms for
CD164L2

Expression for CD164L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD164L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD164L2 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9), Skin - Sun Exposed (Lower leg) (x6.3), Vagina (x5.3), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CD164L2 Gene:

CD164L2

SOURCE GeneReport for Unigene cluster for CD164L2 Gene:

Hs.664836
genes like me logo Genes that share expression patterns with CD164L2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CD164L2 Gene

Orthologs for CD164L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD164L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD164L2 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia CD164L2 34 35
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359977 34
  • 82.07 (n)
mouse
(Mus musculus)
Mammalia Cd164l2 34 16 35
  • 80.9 (n)
cow
(Bos Taurus)
Mammalia CD164L2 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD164L2 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd164l2 34 35
  • 50.14 (n)
Species where no ortholog for CD164L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD164L2 Gene

ENSEMBL:
Gene Tree for CD164L2 (if available)
TreeFam:
Gene Tree for CD164L2 (if available)

Paralogs for CD164L2 Gene

Paralogs for CD164L2 Gene

(1) SIMAP similar genes for CD164L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD164L2: view

Variants for CD164L2 Gene

Sequence variations from dbSNP and Humsavar for CD164L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112027781 -- 27,381,451(+) CAACT(C/G)GAGCC intron-variant
rs112178144 -- 27,380,548(+) GGTGA(A/G)GACAG intron-variant
rs112411593 -- 27,382,050(+) AGCAC(C/T)CCCTC intron-variant
rs112421337 -- 27,384,963(+) CACCA(C/T)GGAAT upstream-variant-2KB
rs112894424 -- 27,381,783(+) ACCTG(C/T)TGTGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD164L2 Gene

Variant ID Type Subtype PubMed ID
esv1006916 CNV deletion 20482838
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for CD164L2 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD164L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD164L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD164L2 Gene

Disorders for CD164L2 Gene

Relevant External Links for CD164L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD164L2

No disorders were found for CD164L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD164L2 Gene

Publications for CD164L2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population. (PMID: 22471352) Lu J. … Jia W. (Clin. Exp. Hypertens. 2012) 3 64

Products for CD164L2 Gene

Sources for CD164L2 Gene

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