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Aliases for CD164L2 Gene

Aliases for CD164L2 Gene

  • CD164 Molecule Like 2 2 3 5
  • CD164 Sialomucin-Like 2 Protein 3
  • CD164 Sialomucin-Like 2 2
  • EAPG6122 3
  • UNQ6122 3

External Ids for CD164L2 Gene

Previous GeneCards Identifiers for CD164L2 Gene

  • GC01M027578
  • GC01M027705
  • GC01M025961

Summaries for CD164L2 Gene

GeneCards Summary for CD164L2 Gene

CD164L2 (CD164 Molecule Like 2) is a Protein Coding gene. An important paralog of this gene is CD164.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD164L2 Gene

Genomics for CD164L2 Gene

Regulatory Elements for CD164L2 Gene

Enhancers for CD164L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027425 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -49.4 -49403 13.6 HDGF PKNOX1 ATF1 ARNT ETS1 TCF12 ZNF766 KLF7 KLF13 NCOA1 ACTG1P20 CD164L2 WASF2 FGR LOC105376892 RNU6-48P TMEM222 PHACTR4 PPP1R8 RNU6-1245P
GH01G027391 1.6 Ensembl ENCODE dbSUPER 20.9 -10.2 -10169 5.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CD164L2 DNAJC8 PHACTR4 GPR3 PIR34425 GC01M027435
GH01G027516 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -140.4 -140434 13.7 CREB3L1 ZFP64 DMAP1 YY1 ZNF548 ZNF263 SP3 MCM3 MEF2D SSRP1 ACTG1P20 NPM1P39 PHACTR4 CD164L2 WASF2 SYTL1 ENSG00000231344 MAP3K6 FAM76A SFN
GH01G027487 1.4 ENCODE dbSUPER 17.4 -107.3 -107335 5.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ACTG1P20 PHACTR4 NPM1P39 DNAJC8 ENSG00000231344 CD164L2 AHDC1 WASF2 ENSG00000243659 GC01M027515
GH01G027445 1.2 Ensembl ENCODE dbSUPER 20.2 -62.2 -62194 0.5 HDGF MXI1 MTA2 CEBPB SIN3A JUNB EBF1 RELA ARID3A TCF7 CD164L2 LOC105376892 WASF2 RNU6-48P ACTG1P20 TMEM222 ENSG00000241169 PIR40118
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD164L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD164L2 Gene

Chromosome:
1
Start:
27,379,100 bp from pter
End:
27,383,380 bp from pter
Size:
4,281 bases
Orientation:
Minus strand

Genomic View for CD164L2 Gene

Genes around CD164L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD164L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD164L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD164L2 Gene

Proteins for CD164L2 Gene

  • Protein details for CD164L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWJ8-C16L2_HUMAN
    Recommended name:
    CD164 sialomucin-like 2 protein
    Protein Accession:
    Q6UWJ8
    Secondary Accessions:
    • B2RPJ0
    • Q5JXD6

    Protein attributes for CD164L2 Gene

    Size:
    174 amino acids
    Molecular mass:
    18534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD164L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD164L2 Gene

Post-translational modifications for CD164L2 Gene

  • Glycosylation at posLast=7171, Asn103, and posLast=116116
  • Modification sites at PhosphoSitePlus

Other Protein References for CD164L2 Gene

No data available for DME Specific Peptides for CD164L2 Gene

Domains & Families for CD164L2 Gene

Protein Domains for CD164L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD164L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWJ8

UniProtKB/Swiss-Prot:

C16L2_HUMAN :
  • Belongs to the CD164 family.
Family:
  • Belongs to the CD164 family.
genes like me logo Genes that share domains with CD164L2: view

No data available for Gene Families for CD164L2 Gene

Function for CD164L2 Gene

genes like me logo Genes that share phenotypes with CD164L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD164L2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD164L2 Gene

Localization for CD164L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD164L2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD164L2 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for CD164L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD164L2: view

Pathways & Interactions for CD164L2 Gene

SuperPathways for CD164L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD164L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CD164L2 Gene

Drugs & Compounds for CD164L2 Gene

No Compound Related Data Available

Transcripts for CD164L2 Gene

mRNA/cDNA for CD164L2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD164L2 Gene

CD164 sialomucin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD164L2 Gene

No ASD Table

Relevant External Links for CD164L2 Gene

GeneLoc Exon Structure for
CD164L2
ECgene alternative splicing isoforms for
CD164L2

Expression for CD164L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD164L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD164L2 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9), Skin - Sun Exposed (Lower leg) (x6.3), Vagina (x5.3), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CD164L2 Gene:

CD164L2

SOURCE GeneReport for Unigene cluster for CD164L2 Gene:

Hs.664836
genes like me logo Genes that share expression patterns with CD164L2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD164L2 Gene

Orthologs for CD164L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD164L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD164L2 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia CD164L2 34 35
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359977 34
  • 82.07 (n)
mouse
(Mus musculus)
Mammalia Cd164l2 34 16 35
  • 80.9 (n)
cow
(Bos Taurus)
Mammalia CD164L2 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD164L2 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd164l2 34 35
  • 50.14 (n)
Species where no ortholog for CD164L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD164L2 Gene

ENSEMBL:
Gene Tree for CD164L2 (if available)
TreeFam:
Gene Tree for CD164L2 (if available)

Paralogs for CD164L2 Gene

Paralogs for CD164L2 Gene

(1) SIMAP similar genes for CD164L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD164L2: view

Variants for CD164L2 Gene

Sequence variations from dbSNP and Humsavar for CD164L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000690253 -- 27,381,640(+) TCCAA(A/C)CCATT intron-variant
rs1001135366 -- 27,384,185(+) CCATC(A/T)GTCCC upstream-variant-2KB
rs1002194981 -- 27,385,119(+) ATCAC(G/T)TGGAC upstream-variant-2KB
rs1002272046 -- 27,378,751(+) TCAAA(A/G)ATGAA downstream-variant-500B
rs1002323172 -- 27,383,019(+) CTCCC(A/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD164L2 Gene

Variant ID Type Subtype PubMed ID
esv1006916 CNV deletion 20482838
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for CD164L2 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD164L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD164L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD164L2 Gene

Disorders for CD164L2 Gene

Relevant External Links for CD164L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD164L2

No disorders were found for CD164L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD164L2 Gene

Publications for CD164L2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population. (PMID: 22471352) Lu J. … Jia W. (Clin. Exp. Hypertens. 2012) 3 64

Products for CD164L2 Gene

Sources for CD164L2 Gene

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