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CD164 Gene

protein-coding   GIFtS: 57
GCID: GC06M109687

CD164 Molecule, Sialomucin

(Previous names: CD164 antigen, sialomucin)
  See CD164-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD164 Molecule, Sialomucin1 2     CD164 Variant C2
CD164 Antigen, Sialomucin1 2     endolyn2
Multi-Glycosylated Core Protein 242 3     Sialomucin Core Protein 242
MGC-242 3     Endolyn3
MGC-24v2 3     CD164 Antigen3
MUC-242 3     

External Ids:    HGNC: 16321   Entrez Gene: 87632   Ensembl: ENSG000001355357   OMIM: 6033565   UniProtKB: Q049003   

Export aliases for CD164 gene to outside databases

Previous GC identifers: GC06M109523 GC06M109710 GC06M109733 GC06M109794 GC06M107253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD164 Gene:
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but
opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164
is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 (PubMed
9680353); Forde et al., 2007 (PubMed 17077324)).(supplied by OMIM, Aug 2008)

GeneCards Summary for CD164 Gene:
CD164 (CD164 molecule, sialomucin) is a protein-coding gene. Diseases associated with CD164 include bruton-type agammaglobulinemia. An important paralog of this gene is CD164L2.

UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to
the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of
umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role
in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by
enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion
into myotubes (By similarity)

Gene Wiki entry for CD164 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD164 gene promoter:
         AP-1   ATF-2   HSF1 (long)   Tal-1beta   E47   SRY   HSF1short   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD164 promoter sequence
   Search Chromatin IP Primers for CD164

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD164


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

CD164 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD164 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109687:  view genomic region     (about GC identifiers)

Start:
109,687,717 bp from pter      End:
109,703,762 bp from pter
Size:
16,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900 (See protein sequence)
Recommended Name: Sialomucin core protein 24 precursor  
Size: 197 amino acids; 20917 Da
Subunit: Homodimer (isoform 4). Interacts with CXCR4
Secondary accessions: B4DQ85 E1P5E7 E1P5E8 E1P5E9 O95413 Q5JSU6 Q9BPV0 Q9NR26
Alternative splicing: 5 isoforms:  Q04900-1   Q04900-2   Q04900-3   Q04900-4   Q04900-5   

Explore the universe of human proteins at neXtProt for CD164: NX_Q04900

Explore proteomics data for CD164 at MOPED

Post-translational modifications: 

  • Highly N- and O-glycosylated; contains sialic acid1
  • The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain1
  • Glycosylation2 at Asn26, Asn32, Asn41, Asn72, Asn77, Asn94, Asn104, Asn121, Ser142, Asn146
  • Modification sites at PhosphoSitePlus

  • See CD164 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001135873.1  NP_001135874.1  NP_001135875.1  NP_001135876.1  NP_006007.2  

    ENSEMBL proteins: 
     ENSP00000402237   ENSP00000314177   ENSP00000309376   ENSP00000275080   ENSP00000427546  
     ENSP00000422999   ENSP00000357957  

    CD164 Human Recombinant Protein Products:

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    Novus Biologicals CD164 Proteins
    Novus Biologicals CD164 Lysate
    Sino Biological Recombinant Protein for CD164
    Sino Biological Cell Lysate for CD164
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD164

     
    Search eBioscience for Proteins for CD164 

    CD164 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CD164 Antibodies
    Abcam antibodies for CD164
    Cloud-Clone Corp. Antibodies for CD164
    Search ThermoFisher Antibodies for CD164
    LSBio Antibodies in human, mouse, rat for CD164

    CD164 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD164
    Cloud-Clone Corp. CLIAs for CD164
    Search eBioscience for ELISAs for CD164 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR007947 CD164_MGC24

    Graphical View of Domain Structure for InterPro Entry Q04900

    ProtoNet protein and cluster: Q04900

    1 Blocks protein domain: IPB007947 CD164 antigen signature

    UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
    Similarity: Belongs to the CD164 family


    Find genes that share domains with CD164           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUC24_HUMAN, Q04900
    Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to
    the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of
    umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role
    in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by
    enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion
    into myotubes (By similarity)
    Induction: Up-regulated by CXCL12 in prostate cancer cell lines

         Genatlas biochemistry entry for CD164:
    cell differentiation antigen CD164,identigfied by monoclonal antibodies 103B2/9E10 and 105A5,expressed in CD34+ B
    cell precursors and in maturing erythroid cells,potent regulator of hematopoiesis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17077324
         
    Find genes that share ontologies with CD164           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD164
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD164

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD164
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD164

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD164:
    hsa-mir-130b-3p (MIRT044166), hsa-mir-215-5p (MIRT024600), hsa-mir-132-3p (MIRT021841), hsa-mir-124-3p (MIRT002730), hsa-mir-93-5p (MIRT028130), hsa-mir-192-5p (MIRT004165)

    Block miRNA regulation of human, mouse, rat CD164 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD164 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-495 hsa-miR-15a hsa-miR-1271 hsa-miR-219-5p hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCD164 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD164
    Predesigned siRNA for gene silencing in human, mouse, rat CD164

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CD164
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CD164 (NM_001142401)
    Sino Biological Human cDNA Clone for CD164
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD164
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD164

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD164
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD164 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD164


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUC24_HUMAN, Q04900: Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type
    I membrane protein. Cell membrane; Single-pass type I membrane protein
    MUC24_HUMAN, Q04900: Isoform 2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    extracellular3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IDA11027692
    GO:0005765lysosomal membrane IEA--
    GO:0005768endosome IDA11027692
    GO:0005886plasma membrane IDA10491205

    Find genes that share ontologies with CD164           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD164 About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with CD164           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD164):
        Lysosome

        Pathway & Disease-focused RT2 Profiler PCR Array including CD164: 
              Hematopoiesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CD164

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for CD164 (Q049002, 3 ENSP000003093764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MYO5BQ9ULV02, ENSP000002850394MINT-5225020 STRING: ENSP00000285039
    ARRB1P494073I2D: score=1 
    CXCR4P610733I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9763543
    GO:0007155cell adhesion IDA10491205
    GO:0007157heterophilic cell-cell adhesion IDA10491205
    GO:0007162negative regulation of cell adhesion NAS10878358
    GO:0007165signal transduction TAS9763543

    Find genes that share ontologies with CD164           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD164 (MUC24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD164 gene (5 alternative transcripts): 
    NM_001142401.1  NM_001142402.1  NM_001142403.1  NM_001142404.1  NM_006016.4  

    Unigene Cluster for CD164:

    CD164 molecule, sialomucin
    Hs.520313  [show with all ESTs]
    Unigene Representative Sequence: BC040317
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415861 ENST00000413644 ENST00000324953 ENST00000310786 ENST00000275080
    ENST00000499860 ENST00000512821 ENST00000504373 ENST00000506649 ENST00000512212
    ENST00000368961(uc003ptd.3 uc003ptf.3 uc011eap.2 uc003pte.3 uc010kdn.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD164 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD164 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-495 hsa-miR-15a hsa-miR-1271 hsa-miR-219-5p hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCD164 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD164
    Predesigned siRNA for gene silencing in human, mouse, rat CD164
    Clone
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    OriGene clones in human, mouse for CD164 (see all 28)
    OriGene ORF clones in mouse, rat for CD164
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CD164 (NM_001142401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD164
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD164
    Primer
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    OriGene qPCR primer pairs and template standards for CD164
    OriGene qSTAR qPCR primer pairs in human, mouse for CD164
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD164
      QuantiTect SYBR Green Assays in human, mouse, rat CD164
      QuantiFast Probe-based Assays in human, mouse, rat CD164

    Additional mRNA sequence: 

    AF106518.1 AF263279.1 AF299341.1 AF299342.1 AF299343.1 AK298684.1 AK301692.1 AK303525.1 
    AK307193.1 AK308664.1 AK310854.1 AK312357.1 AK315908.1 BC011522.2 BC037914.1 BC040317.1 
    D14043.1 FJ200494.1 

    Selected DOTS entries (see all 30):

    DT.97805095  DT.319740  DT.95372711  DT.100682040  DT.91899463  DT.100682046  DT.97802504  DT.95332075 
    DT.100682037  DT.92462851  DT.95128496  DT.100733785  DT.100862754  DT.121349161  DT.95372708  DT.97864446 
    DT.121349199  DT.40303984  DT.92326281  DT.95282339  DT.100682041  DT.100682047  DT.121349166  DT.92462853 

    Selected AceView cDNA sequences (see all 948):

    CA438535 CA388815 AI913536 AI400145 BG498467 BM994050 BU626568 BI712513 
    BM705733 AI278543 N40024 BM142678 AA384824 BG562960 BQ215111 BG620944 
    AF299341 CN483422 AA346841 BG057317 AW575001 BG506557 CA435316 AI146586 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD164 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
    SP1:                          -     -     -                       -     -                       -     -               
    SP2:                          -     -     -                       -     -                                             
    SP3:                                      -                       -     -                                             
    SP4:                          -     -     -                       -     -     -                                       
    SP5:                          -     -     -                 -     -     -                                             


    ECgene alternative splicing isoforms for CD164

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD164 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD164 Expression
    About this image


    CD164 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 27) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CD164 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD164 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520313

    UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
    Tissue specificity: Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform
    1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone
    metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue
    metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic
    adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells

        Pathway & Disease-focused RT2 Profiler PCR Array including CD164: 
              Hematopoiesis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CD164
    OriGene qSTAR qPCR primer pairs in human, mouse for CD164
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD164
    QuantiTect SYBR Green Assays in human, mouse, rat CD164
    QuantiFast Probe-based Assays in human, mouse, rat CD164
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD164

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD164 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1641 , 5 CD164 antigen1, 5 77.01(n)1
    68.45(a)1
      10 (22.46 cM)5
    535991  NM_016898.21  NP_058594.11 
     415195005 
    chicken
    (Gallus gallus)
    Aves CD1646
    CD164 molecule, sialomucin
    33(a)
    1 ↔ 1
    3(66357144-66365037)
    lizard
    (Anolis carolinensis)
    Reptilia CD1646
    CD164 molecule, sialomucin
    81(a)
    1 ↔ 1
    1(191113262-191113402)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ613981.12   -- 76.87(n)    BJ613981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd1646
    CD164 molecule, sialomucin
    41(a)
    1 ↔ 1
    20(32157440-32177943) ENSDARG00000013628


    ENSEMBL Gene Tree for CD164 (if available)
    TreeFam Gene Tree for CD164 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD164 gene
    CD164L22  
    1 SIMAP similar gene for CD164 using alignment to 4 protein entries:     MUC24_HUMAN (see all proteins):
    CD164L2

    Find genes that share paralogs with CD164           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CD164
    PGOHUM00000251276


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD164 (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493816761,2
    --109687228(+) CCTTAC/TAGGTT 5 -- int10--------
    rs1824141221,2
    --109687269(+) TCAAGC/TCCACT 5 -- int10--------
    rs1476032921,2
    C--109687290(+) GAACA-/TTAATT 5 -- int10--------
    rs1157509851,2
    C,F--109687370(+) TAGTTC/ATTGGT 5 -- int11Minor allele frequency- A:0.04WA 118
    rs743364441,2
    C,F--109687436(+) AGATTA/GTAAAA 5 -- int12Minor allele frequency- G:0.04WA EA 238
    rs1874474821,2
    --109687448(+) CAAGAC/TAGTAT 5 -- int10--------
    rs1437493241,2
    --109687484(+) ACAGCA/GTAATT 5 -- int10--------
    rs737627091,2
    C,F--109687529(+) CTCCCA/TCAAGT 5 -- int14Minor allele frequency- T:0.34WA CSA 123
    rs1481423821,2
    --109687594(+) GAACAC/TGTGCC 5 -- int10--------
    rs1928087121,2
    --109687775(+) ATTGGC/TTTTGC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for CD164 (109687717 - 109703762 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD164: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD164
    DNA2.0 Custom Variant and Variant Library Synthesis for CD164

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603356    OMIM disorders: --

    1 disease for CD164:    
    About MalaCards
    bruton-type agammaglobulinemia

    1 disease from the University of Copenhagen DISEASES database for CD164:
    Bruton-type agammaglobulinemia

    Find genes that share disorders with CD164           About GenesLikeMe

    3 Novoseek inferred disease relationships for CD164 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric carcinoma 49.7 3 10491205 (1), 10620506 (1)
    metastasis 0 2 16859559 (2)
    carcinoma 0 1 10833281 (1)

    Genetic Association Database (GAD): CD164

    Export disorders for CD164 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD164 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CD164)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. (PubMed id 9763543)1, 2, 3, 9 Zannettino A.C.W....Simmons P.J. (Blood 1998)
    2. CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. (PubMed id 10878358)1, 2, 9 Doyonnas R....Watt S.M. (J. Immunol. 2000)
    3. The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. (PubMed id 16859559)1, 2, 9 Havens A.M.... Taichman R.S. (BMC Cancer 2006)
    4. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. (PubMed id 9680353)1, 3, 9 Watt S.M....Butler L.H. (Blood 1998)
    5. A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. (PubMed id 1478919)1, 2, 9 Masuzawa Y.... Muramatsu T. (J. Biochem. 1992)
    6. Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells. (PubMed id 17077324)1, 2, 9 Forde S.... Watt S.M. (Blood 2007)
    7. Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. (PubMed id 11027692)1, 2, 9 Chan J.Y.-H.... Watt S.M. (J. Biol. Chem. 2001)
    8. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    9. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8763 HGNC: 1632 AceView: CD164 Ensembl:ENSG00000135535 euGenes: HUgn8763
    ECgene: CD164 Kegg: 8763 H-InvDB: CD164

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD164 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD164 gene:
    Search GeneIP for patents involving CD164

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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