Aliases for CD164 Gene
Aliases for CD164 Gene
External Ids for CD164 Gene
- HGNC: 1632
- Entrez Gene: 8763
- Ensembl: ENSG00000135535
- OMIM: 603356
- UniProtKB: Q04900
Previous GeneCards Identifiers for CD164 Gene
- GC06M109523
- GC06M109710
- GC06M109733
- GC06M109794
- GC06M109687
- GC06M107253
Summaries for CD164 Gene
-
This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
GeneCards Summary for CD164 Gene
CD164 (CD164 Molecule) is a Protein Coding gene. Diseases associated with CD164 include Autosomal Dominant Nonsyndromic Deafness 66 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Lysosome. An important paralog of this gene is CD164L2.
UniProtKB/Swiss-Prot for CD164 Gene
-
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD164 Gene
Genomics for CD164 Gene
Regulatory Elements for CD164 Gene
Enhancers for CD164 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CD164 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD164 gene promoter:
Regulatory Element Products
Genomic Location for CD164 Gene
- Chromosome:
- 6
- Start:
- 109,366,514 bp from pter
- End:
- 109,382,559 bp from pter
- Size:
- 16,046 bases
- Orientation:
- Minus strand
Genomic View for CD164 Gene
Genes around CD164 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC
CD164 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD164 Gene
Proteins for CD164 Gene
-
Protein details for CD164 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q04900-MUC24_HUMAN
- Recommended name:
- Sialomucin core protein 24
- Protein Accession:
- Q04900
- B4DQ85
- E1P5E7
- E1P5E8
- E1P5E9
- O95413
- Q5JSU6
- Q9BPV0
- Q9NR26
Protein attributes for CD164 Gene
- Size:
- 197 amino acids
- Molecular mass:
- 20917 Da
- Quaternary structure:
-
- Homodimer (isoform 4). Interacts with CXCR4.
Protein Expression for CD164 Gene
Post-translational modifications for CD164 Gene
- Highly N- and O-glycosylated; contains sialic acid.
- The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.
- Glycosylation at posLast=2626, Asn32, Asn41, posLast=7272, Asn77, Asn94, posLast=104104, Asn121, Ser142, and posLast=146146
- Modification sites at PhosphoSitePlus
Other Protein References for CD164 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD164 (CD164)
-
Custom Antibody ServicesOriGene Antibodies for CD164
- Novus Biologicals Antibodies for CD164
-
Cloud-Clone Corp. Antibodies for CD164
- Invitrogen Antibodies for CD164
- antibodies-online Antibodies for CD164: See all 25
- Search GeneTex for Antibodies for CD164
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD164
Protein Products
-
OriGene Purified Proteins for CD164
- Search Origene for MassSpec and Protein Over-expression Lysates for CD164
- Origene Custom Protein Services for CD164
- Sino Biological Recombinant Proteins for CD164
- Sino Biological Cell Lysates for CD164
-
Cloud-Clone Corp. Proteins for CD164
- antibodies-online Proteins for CD164: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CD164
Assay Products
- antibodies-online Kits for CD164: See all 3
No data available for DME Specific Peptides for CD164 Gene
Domains & Families for CD164 Gene
Gene Families for CD164 Gene
Protein Domains for CD164 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD164 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q04900- Family:
-
- Belongs to the CD164 family.
Function for CD164 Gene
Molecular function for CD164 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD164,identigfied by monoclonal antibodies 103B2/9E10 and 105A5,expressed in CD34+ B cell precursors and in maturing erythroid cells,potent regulator of hematopoiesis
- UniProtKB/Swiss-Prot Function:
- Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by CXCL12 in prostate cancer cell lines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17077324 |
Phenotypes for CD164 Gene
- GenomeRNAi human phenotypes for CD164:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD164
-
- Search ViGene Biosciences for CD164
CRISPR Products
-
OriGene CRISPR knockouts for CD164
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD164
- GenScript: Design CRISPR guide RNA sequences for CD164
miRNA for CD164 Gene
- miRTarBase miRNAs that target CD164
-
- hsa-mir-124-3p (MIRT002730)
- hsa-mir-192-5p (MIRT004165)
- hsa-mir-132-3p (MIRT021841)
- hsa-mir-215-5p (MIRT024600)
- hsa-mir-93-5p (MIRT028130)
- hsa-mir-130b-3p (MIRT044166)
- hsa-let-7c-3p (MIRT098126)
- hsa-mir-495-3p (MIRT098136)
- hsa-mir-5688 (MIRT098138)
- hsa-mir-513a-3p (MIRT098149)
- hsa-mir-513c-3p (MIRT098152)
- hsa-mir-3606-3p (MIRT098154)
- hsa-mir-181b-3p (MIRT217350)
- hsa-mir-181b-2-3p (MIRT217351)
- hsa-mir-4420 (MIRT217354)
- hsa-mir-548av-3p (MIRT315255)
- hsa-mir-548k (MIRT315319)
- hsa-mir-548l (MIRT315320)
- hsa-mir-548av-5p (MIRT315337)
- hsa-mir-8054 (MIRT315339)
- hsa-mir-570-3p (MIRT479661)
- hsa-mir-19a-3p (MIRT479662)
- hsa-mir-19b-3p (MIRT479663)
- hsa-mir-1231 (MIRT512158)
- hsa-mir-632 (MIRT512159)
- hsa-mir-4288 (MIRT512160)
- hsa-mir-6755-3p (MIRT512161)
- hsa-mir-346 (MIRT512162)
- hsa-mir-4480 (MIRT512163)
- hsa-mir-4793-3p (MIRT512164)
- hsa-mir-3130-3p (MIRT512165)
- hsa-mir-335-5p (MIRT512166)
- hsa-mir-548g-3p (MIRT512167)
- hsa-mir-4670-3p (MIRT548958)
- hsa-mir-586 (MIRT548959)
- hsa-mir-4718 (MIRT558867)
- hsa-mir-520f-5p (MIRT558868)
- hsa-mir-4509 (MIRT558869)
- hsa-mir-4744 (MIRT558870)
- hsa-mir-4428 (MIRT558871)
- hsa-mir-1283 (MIRT568124)
- hsa-mir-524-5p (MIRT568125)
- hsa-mir-520d-5p (MIRT568126)
- hsa-mir-3157-5p (MIRT704861)
- hsa-mir-4691-3p (MIRT704862)
- hsa-mir-6513-3p (MIRT704863)
- hsa-mir-512-5p (MIRT704864)
- hsa-mir-551b-5p (MIRT704865)
- hsa-mir-186-5p (MIRT704866)
- hsa-mir-3133 (MIRT704867)
- hsa-mir-4263 (MIRT704868)
- hsa-mir-376b-3p (MIRT704869)
- hsa-mir-376a-3p (MIRT704870)
- hsa-mir-653-3p (MIRT704871)
- hsa-mir-4724-3p (MIRT704872)
- hsa-mir-6740-3p (MIRT704873)
- hsa-mir-27b-5p (MIRT704874)
- hsa-mir-1208 (MIRT704875)
- hsa-mir-6760-3p (MIRT704876)
- hsa-mir-6782-3p (MIRT704877)
miRNA Products
- Search ViGene Biosciences for CD164
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD164
- Browse OriGene Inhibitory RNA Products For CD164
Clone Products
-
OriGene ORF clones in human for CD164
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD164
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD164
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD164
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD164
Cell Line Products
-
Horizon Cell Lines for CD164
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD164 Gene
Localization for CD164 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD164 Gene
- Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005764 | lysosome | IEA,IDA | 11027692 |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005768 | endosome | IDA,IEA | 11027692 |
| GO:0005886 | plasma membrane | IDA,TAS | 10491205 |
Pathways & Interactions for CD164 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lysosome |
-
|
|
| 2 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
Pathways by source for CD164 Gene
1 KEGG pathway for CD164 Gene
1 R&D Systems pathway for CD164 Gene
Interacting Proteins for CD164 Gene
Selected Interacting proteins:
Q04900-MUC24_HUMAN
ENSP00000309376
for CD164 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | TAS | 9763543 |
| GO:0007155 | cell adhesion | IDA,TAS | 10491205 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IDA | 10491205 |
| GO:0007162 | negative regulation of cell adhesion | NAS | 10878358 |
| GO:0007165 | signal transduction | TAS | 9763543 |
No data available for SIGNOR curated interactions for CD164 Gene
Transcripts for CD164 Gene
mRNA/cDNA for CD164 Gene
- (6) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (948) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD164 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD164
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD164
- GenScript: Design CRISPR guide RNA sequences for CD164
miRNA Products
- Search ViGene Biosciences for CD164
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD164
- Browse OriGene Inhibitory RNA Products For CD164
Clone Products
-
OriGene ORF clones in human for CD164
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD164
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD164
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD164
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD164
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP9: |
Expression for CD164 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Nucleus Pulposus
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Stem Cells Liver Bud
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Primitive Streak (Early Embryonic Tissues)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Pancreas (Endocrine System)
-
Thymus (Hematopoietic System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Testis (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD164 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD164 Gene:
CD164SOURCE GeneReport for Unigene cluster for CD164 Gene:
Hs.520313mRNA Expression by UniProt/SwissProt for CD164 Gene:
Q04900-MUC24_HUMAN
Tissue specificity:
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
Evidence on tissue expression from TISSUES for CD164 Gene
- Nervous system(4.9)
- Blood(4.7)
- Intestine(4.7)
- Bone marrow(4.6)
- Kidney(4.1)
- Lung(3.8)
- Skin(3.6)
- Liver(3.1)
- Pancreas(2.7)
- Stomach(2.5)
- Thyroid gland(2.3)
- Gall bladder(2.1)
- Spleen(2.1)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CD164
-
OriGene qPCR primer pairs and template standards for CD164
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD164 Gene
Orthologs for CD164 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD164 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CD164 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CD164 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd164 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd164 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CD164 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CD164 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD164 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD164 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | cd164 35 |
|
OneToOne |
- Species where no ortholog for CD164 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CD164 Gene
(1) SIMAP similar genes for CD164 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for CD164 Gene
Variants for CD164 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs876661402 | Pathogenic | 109,368,871(-) | AAGAA(C/T)GAAAT | intron-variant, reference, stop-gained | |
| rs1000223842 | -- | 109,374,232(+) | TTAGC(A/C)AAGAG | intron-variant | |
| rs1000253734 | -- | 109,378,182(+) | ATCCT(G/T)CTAAC | intron-variant | |
| rs1000262270 | -- | 109,381,730(+) | CTTTC(C/T)CGGAC | intron-variant, utr-variant-5-prime | |
| rs1000294827 | -- | 109,381,407(+) | TAAGA(A/C)AATTT | intron-variant |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.81;
17.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CD164 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD164 Gene
Disorders for CD164 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal dominant nonsyndromic deafness 66 |
|
|
| autosomal dominant non-syndromic sensorineural deafness type dfna |
|
|
| pollen allergy |
|
|
| autosomal dominant nonsyndromic deafness |
|
|
| prostate cancer |
|
|
Search CD164 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MUC24_HUMAN- Deafness, autosomal dominant, 66 (DFNA66) [MIM:616969]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:26197441}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CD164
No data available for Genatlas for CD164 Gene
Publications for CD164 Gene
- The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. (PMID: 9763543) Zannettino A.C.W. … Simmons P.J. (Blood 1998) 2 3 4 22 64
- Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells. (PMID: 17077324) Forde S. … Watt S.M. (Blood 2007) 3 4 22 64
- The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. (PMID: 16859559) Havens A.M. … Taichman R.S. (BMC Cancer 2006) 3 4 22 64
- Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. (PMID: 11027692) Chan J.Y.-H. … Watt S.M. (J. Biol. Chem. 2001) 3 4 22 64
- CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. (PMID: 10878358) Doyonnas R. … Watt S.M. (J. Immunol. 2000) 3 4 22 64
Products for CD164 Gene
- R&D Systems Antibodies for CD164 (CD164)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD164
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD164
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD164
- Search Origene for MassSpec and Protein Over-expression Lysates for CD164
- Origene Custom Protein Services for CD164
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CD164
- Browse OriGene Inhibitory RNA Products For CD164
- OriGene qPCR primer pairs and template standards for CD164
- OriGene qPCR primer pairs for CD164
- OriGene CRISPR knockouts for CD164
- OriGene ORF clones in human for CD164
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD164
- GenScript: Next-day shipping cDNA ORF clone for CD164 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD164
- GenScript Custom Assay Services for CD164
- GenScript Custom overexpressing Cell Line Services for CD164
- GenScript: Design CRISPR guide RNA sequences for CD164
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD164
- Sino Biological Human cDNA Clone for CD164
- Sino Biological Recombinant Proteins for CD164
- Sino Biological Cell Lysates for CD164
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CD164
- Novus Biologicals proteins and lysates for CD164
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CD164
- Cloud-Clone Corp. Proteins for CD164
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for CD164: See all 25
- antibodies-online Kits for CD164: See all 3
- antibodies-online Proteins for CD164: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CD164
- Search GeneTex for Proteins for CD164
- Search ViGene Biosciences for CD164
- Santa Cruz Biotechnology (SCBT) Antibodies for CD164
- Search Santa Cruz Biotechnology (SCBT) for CD164 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD164
- Horizon Cell Lines for CD164
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD164
- VectorBuilder custom plasmid, inducible vectors for CD164
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD164
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CD164 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer