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Aliases for CD164 Gene

Aliases for CD164 Gene

  • CD164 Molecule, Sialomucin 2 3
  • Multi-Glycosylated Core Protein 24 3 4
  • CD164 Antigen, Sialomucin 2 3
  • Endolyn 3 4
  • MGC-24v 3 4
  • MGC-24 3 4
  • MUC-24 3 4
  • Sialomucin Core Protein 24 3
  • CD164 Variant C 3
  • CD164 Antigen 4

External Ids for CD164 Gene

Previous GeneCards Identifiers for CD164 Gene

  • GC06M109523
  • GC06M109710
  • GC06M109733
  • GC06M109794
  • GC06M109687
  • GC06M107253

Summaries for CD164 Gene

Entrez Gene Summary for CD164 Gene

  • Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008]

GeneCards Summary for CD164 Gene

CD164 (CD164 Molecule, Sialomucin) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is CD164L2.

UniProtKB/Swiss-Prot for CD164 Gene

  • Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).

Gene Wiki entry for CD164 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD164 Gene

Genomics for CD164 Gene

Regulatory Elements for CD164 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD164 Gene

Start:
109,366,514 bp from pter
End:
109,382,559 bp from pter
Size:
16,046 bases
Orientation:
Minus strand

Genomic View for CD164 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD164 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD164 Gene

Proteins for CD164 Gene

  • Protein details for CD164 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04900-MUC24_HUMAN
    Recommended name:
    Sialomucin core protein 24
    Protein Accession:
    Q04900
    Secondary Accessions:
    • B4DQ85
    • E1P5E7
    • E1P5E8
    • E1P5E9
    • O95413
    • Q5JSU6
    • Q9BPV0
    • Q9NR26

    Protein attributes for CD164 Gene

    Size:
    197 amino acids
    Molecular mass:
    20917 Da
    Quaternary structure:
    • Homodimer (isoform 4). Interacts with CXCR4.

    Alternative splice isoforms for CD164 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD164 Gene

Proteomics data for CD164 Gene at MOPED

Post-translational modifications for CD164 Gene

  • Highly N- and O-glycosylated; contains sialic acid.
  • The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain
  • Glycosylation at Asn26, Asn32, Asn41, Asn72, Asn77, Asn94, Asn104, Asn121, Ser142, and Asn146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD164 Gene

Domains for CD164 Gene

Gene Families for CD164 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD164 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD164 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04900

UniProtKB/Swiss-Prot:

MUC24_HUMAN :
  • Q04900
Family:
  • Belongs to the CD164 family.
genes like me logo Genes that share domains with CD164: view

Function for CD164 Gene

Molecular function for CD164 Gene

GENATLAS Biochemistry: cell differentiation antigen CD164,identigfied by monoclonal antibodies 103B2/9E10 and 105A5,expressed in CD34+ B cell precursors and in maturing erythroid cells,potent regulator of hematopoiesis
UniProtKB/Swiss-Prot Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by CXCL12 in prostate cancer cell lines.

Gene Ontology (GO) - Molecular Function for CD164 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17077324
genes like me logo Genes that share ontologies with CD164: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD164

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD164 Gene

Localization for CD164 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD164 Gene

Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD164 Gene COMPARTMENTS Subcellular localization image for CD164 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CD164 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005764 lysosome IDA 11027692
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IDA 11027692
GO:0005886 plasma membrane IDA 10491205
genes like me logo Genes that share ontologies with CD164: view

Pathways for CD164 Gene

SuperPathways for CD164 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with CD164: view

Pathways by source for CD164 Gene

1 KEGG pathway for CD164 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD164 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9763543
GO:0007155 cell adhesion IDA 10491205
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA 10491205
GO:0007162 negative regulation of cell adhesion NAS 10878358
GO:0007165 signal transduction TAS 9763543
genes like me logo Genes that share ontologies with CD164: view

Transcripts for CD164 Gene

Unigene Clusters for CD164 Gene

CD164 molecule, sialomucin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD164

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD164 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9:

Relevant External Links for CD164 Gene

GeneLoc Exon Structure for
CD164
ECgene alternative splicing isoforms for
CD164

Expression for CD164 Gene

mRNA expression in normal human tissues for CD164 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD164 Gene

SOURCE GeneReport for Unigene cluster for CD164 Gene Hs.520313

mRNA Expression by UniProt/SwissProt for CD164 Gene

Q04900-MUC24_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
genes like me logo Genes that share expressions with CD164: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD164 Gene

Orthologs for CD164 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD164 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD164 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD164 35
  • 79.86 (n)
  • 69.27 (a)
CD164 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD164 35
  • 82.37 (n)
  • 74.64 (a)
CD164 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd164 35
  • 77.01 (n)
  • 68.45 (a)
Cd164 16
Cd164 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD164 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD164 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd164 35
  • 74.17 (n)
  • 63.87 (a)
chicken
(Gallus gallus)
Aves CD164 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD164 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd164 36
  • 41 (a)
OneToOne
Species with no ortholog for CD164:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD164 Gene

ENSEMBL:
Gene Tree for CD164 (if available)
TreeFam:
Gene Tree for CD164 (if available)

Paralogs for CD164 Gene

Paralogs for CD164 Gene

Selected SIMAP similar genes for CD164 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CD164 Gene

genes like me logo Genes that share paralogs with CD164: view

Variants for CD164 Gene

Sequence variations from dbSNP and Humsavar for CD164 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7372 -- 109,366,911(-) AAACA(C/T)AACAA utr-variant-3-prime
rs8465 -- 109,367,335(+) ATGAA(A/C)CAAAG utr-variant-3-prime
rs11251 -- 109,368,704(-) AGCAT(A/C)ATCCG utr-variant-3-prime, intron-variant
rs699700 -- 109,367,528(+) GAAGA(A/C/T)GACCC utr-variant-3-prime
rs974034 -- 109,368,228(-) AAGCA(C/T)CTTAT utr-variant-3-prime

Relevant External Links for CD164 Gene

HapMap Linkage Disequilibrium report
CD164

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD164 Gene

Disorders for CD164 Gene

(1) University of Copenhagen DISEASES for CD164 Gene

(3) Novoseek inferred disease relationships for CD164 Gene

Disease -log(P) Hits PubMed IDs
gastric carcinoma 49.7 2
metastasis 0 2
carcinoma 0 1

Relevant External Links for CD164

Genetic Association Database (GAD)
CD164
genes like me logo Genes that share disorders with CD164: view

No data available for UniProtKB/Swiss-Prot for CD164 Gene

Publications for CD164 Gene

  1. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. (PMID: 9763543) Zannettino A.C.W. … Simmons P.J. (Blood 1998) 2 3 4 23
  2. CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. (PMID: 10878358) Doyonnas R. … Watt S.M. (J. Immunol. 2000) 3 4 23
  3. Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. (PMID: 11027692) Chan J.Y.-H. … Watt S.M. (J. Biol. Chem. 2001) 3 4 23
  4. A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. (PMID: 1478919) Masuzawa Y. … Muramatsu T. (J. Biochem. 1992) 3 4 23
  5. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. (PMID: 9680353) Watt S.M. … Butler L.H. (Blood 1998) 2 3 23

Products for CD164 Gene

Sources for CD164 Gene

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