Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD164 Gene

protein-coding   GIFtS: 55
GCID: GC06M109687

CD164 molecule, sialomucin

(Previous names: CD164 antigen, sialomucin )
 Explore 10 diseases affiliated with
CD164 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD164    

Aliases
for CD164 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD164 Molecule, Sialomucin1 2     MGC-24v2 3
MGC-241 2 3     Endolyn3
MUC-241 2 3     Sialomucin Core Protein 242
CD164 Antigen, Sialomucin1 2     Endolyn3
Multi-Glycosylated Core Protein 242 3     CD164 Antigen3

External Ids:    HGNC: 16321   Entrez Gene: 87632   Ensembl: ENSG000001355357   OMIM: 6033565   UniProtKB: Q049003   

Export aliases for CD164 gene to outside databases

Previous GC identifers: GC06M109523 GC06M109710 GC06M109733 GC06M109794 GC06M107253


Summaries
for CD164 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD164:
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing
roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I
integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 (PubMed 9680353); Forde et
al., 2007 (PubMed 17077324)).(supplied by OMIM, Aug 2008)

UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the
stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord
blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer
metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell
motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity)

Gene Wiki entry for CD164


Genomic Views
for CD164 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD164 gene promoter:
         AP-1   ATF-2   HSF1 (long)   Tal-1beta   E47   SRY   HSF1short   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD164 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD164

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD164


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

CD164 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD164 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109687:  view genomic region     (about GC identifiers)

Start:
 109,687,717 bp from pter      End:
 109,703,762 bp from pter
Size:
 16,046 bases      Orientation:
 minus strand

Proteins
for CD164 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900 (See protein sequence)
Recommended Name: Sialomucin core protein 24 precursor  
Size: 197 amino acids; 20917 Da
Subunit: Homodimer (isoform 4). Interacts with CXCR4
Subcellular location: Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
membrane protein. Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted (Potential)
Secondary accessions: B4DQ85 E1P5E7 E1P5E8 E1P5E9 O95413 Q5JSU6 Q9BPV0 Q9NR26
Alternative splicing: 5 isoforms:  Q04900-1   Q04900-2   Q04900-3   Q04900-4   Q04900-5   

Explore the universe of human proteins at neXtProt for CD164: NX_Q04900

Post-translational modifications:

  • Highly N- and O-glycosylated; contains sialic acid1
  • The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04900

    • CD164 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001135873.1  NP_001135874.1  NP_001135875.1  NP_001135876.1  NP_006007.2  

    ENSEMBL proteins: 
     ENSP00000402237   ENSP00000314177   ENSP00000309376   ENSP00000275080   ENSP00000427546  
     ENSP00000422999   ENSP00000357957  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CD164
    OriGene Protein Over-expression Lysate: CD164
    OriGene Custom Protein Services for CD164 
    GenScript Custom Purified and Recombinant Proteins Services for CD164
    Novus Biologicals CD164 Proteins
    Novus Biologicals CD164 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD164

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IDA11027692
    GO:0005765lysosomal membrane IEA--
    GO:0005768endosome IDA11027692
    GO:0005886plasma membrane IDA10491205


    CD164 for ontologies           About GeneDecksing



    CD164 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD164
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CD164 
    GenScript Custom Superior Antibodies Services for CD164
    Novus Biologicals CD164 Antibodies
    Search for Antibodies for CD164 at Abcam  
    Uscn Antibodies for CD164
    Search ThermoFisher Antibodies for CD164

    Assay Products for CD164: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD164
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CD164

    Protein Domains /
    Families
    for CD164 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD164 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007947 CD164_MGC24

    Graphical View of Domain Structure for InterPro Entry Q04900

    ProtoNet protein and cluster: Q04900

    1 Blocks protein family: IPB007947 CD164 antigen signature

    UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
    Similarity: Belongs to the CD164 family


    Function
    for CD164 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
    Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the
    stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord
    blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer
    metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell
    motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity)
    Induction: Up-regulated by CXCL12 in prostate cancer cell lines

         Genatlas biochemistry entry for CD164:
    cell differentiation antigen CD164,identigfied by monoclonal antibodies 103B2/9E10 and 105A5,expressed in CD34+ B cell
    precursors and in maturing erythroid cells,potent regulator of hematopoiesis

    miRNA
    Products:            		miRTarBase miRNAs that target CD164:
    hsa-mir-124 (MIRT002730), hsa-mir-192 (MIRT004165)

    OriGene 3'-UTR Clone (see all 5): CD164
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD164
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CD164 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-495 hsa-miR-15a hsa-miR-1271 hsa-miR-219-5p hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CD164 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD164 (see all 7)
    OriGene shRNA RFP: CD164
    OriGene siRNA: CD164
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD164

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD164

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD164 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD164 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): CD164 (NM_001142401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD164
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD164 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD164
    Search LifeMap BioReagents cell lines for CD164

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD164

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17077324


    CD164 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CD164 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CD164):
        Lysosome


    CD164 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD164

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for CD164 (Q049002, 3 ENSP000003093764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MYO5BQ9ULV02, ENSP000002850394MINT-5225020 STRING: ENSP00000285039
    ARRB1P494073I2D: score=1 
    CXCR4P610733I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9763543
    GO:0007155cell adhesion IDA10491205
    GO:0007157heterophilic cell-cell adhesion IDA10491205
    GO:0007162negative regulation of cell adhesion NAS10878358
    GO:0007165signal transduction TAS9763543


    CD164 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD164 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD164
    Search CenterWatch for drugs/clinical trials and news about CD164 / MUC24 

    Transcripts
    for CD164 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD164 gene (5 alternative transcripts): 
    NM_001142401.1  NM_001142402.1  NM_001142403.1  NM_001142404.1  NM_006016.4  

    Unigene Cluster for CD164:

    CD164 molecule, sialomucin
    Hs.520313  [show with all ESTs]
    Unigene Representative Sequence: BC040317
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415861 ENST00000413644 ENST00000324953 ENST00000310786 ENST00000275080
    ENST00000499860 ENST00000512821 ENST00000504373 ENST00000506649 ENST00000512212
    ENST00000368961(uc003ptd.3 uc003ptf.3 uc011eap.2 uc003pte.3 uc010kdn.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): CD164
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD164
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CD164 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-495 hsa-miR-15a hsa-miR-1271 hsa-miR-219-5p hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: CD164 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD164 (see all 7)
    OriGene shRNA RFP: CD164
    OriGene siRNA: CD164
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD164
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD164 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD164 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): CD164 (NM_001142401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD164
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD164 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD164
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD164
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD164
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD164

    Additional cDNA sequence: 

    AF106518.1 AF263279.1 AF299341.1 AF299342.1 AF299343.1 AK298684.1 AK301692.1 AK303525.1 
    AK307193.1 AK308664.1 AK310854.1 AK312357.1 AK315908.1 BC011522.2 BC037914.1 BC040317.1 
    D14043.1 

    24/29 DOTS entries (see all 29):

    DT.97805095  DT.319740  DT.100682040  DT.97802504  DT.95372711  DT.91899463  DT.100682046  DT.95332075 
    DT.100682037  DT.92462851  DT.100733785  DT.100862754  DT.121349161  DT.95372708  DT.97864446  DT.92326281 
    DT.95128496  DT.95282339  DT.100682041  DT.100682047  DT.121349166  DT.92462860  DT.95372701  DT.95372707 

    24/948 AceView cDNA sequences (see all 948):

    AI095578 BM790931 AI627823 AI580774 BQ631186 CR622213 BM979500 BX505879 
    AW611767 AA307899 BM994050 CF243089 BX479789 BG611712 BG533960 T29789 
    AW583451 N40024 AI278543 BU626568 BP380466 BM829890 BC040317 CN483137 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CD164 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
    SP1:                          -     -     -                       -     -                       -     -               
    SP2:                          -     -     -                       -     -                                             
    SP3:                                      -                       -     -                                             
    SP4:                          -     -     -                       -     -     -                                       
    SP5:                          -     -     -                 -     -     -                                             


    ECgene alternative splicing isoforms for CD164

    Expression
    for CD164 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD164 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD164 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/24 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 24) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See CD164 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD164

    SOURCE GeneReport for Unigene cluster: Hs.520313

    UniProtKB/Swiss-Prot: MUC24_HUMAN, Q04900
    Tissue specificity: Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is
    expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than
    in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is
    expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is
    expressed by both hematopoietic progenitor cells and bone marrow stromal cells

        SABiosciences Expression via Pathway-Focused PCR Array including CD164: 
              Hematopoiesis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD164
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD164
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD164
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD164
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD164

    Orthologs
    for CD164 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD164 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd1641 , 5 CD164 antigen1, 5 76.83(n)1
    68.98(a)1    		   10 (22.46 cM)5
    535991  NM_016898.21  NP_058594.11 
     415195005 
    chicken
    (Gallus gallus)    		 Aves CD1641 CD164 molecule, sialomucin 56.52(n)
    50.72(a)    		   395380  XM_426183.3  XP_426183.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CD1646
    		 --
    		 83(a)
    		 1 ↔ 1
    		 1(191113262-191113402)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ613981.12   -- 76.87(n)    BJ613981.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cd1641 CD164 molecule, sialomucin 51.82(n)
    51.82(a)    		   555639  NM_001044791.2  NP_001038256.1 


    ENSEMBL Gene Tree for CD164 (if available)
    TreeFam Gene Tree for CD164 (if available) 

    Paralogs
    for CD164 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD164 gene
    CD164L22  
    1 SIMAP similar gene for CD164 using alignment to 4 protein entries:     MUC24_HUMAN (see all proteins):
    CD164L2

    CD164 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD164
    PGOHUM00000251276


    Genomic Variants
    for CD164 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/319 NCBI SNPs in CD164 are shown (see all 319)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1493816761,2
    		--109687228(+) CCTTAC/TAGGTT 5 -- int10--------
    rs1824141221,2
    		--109687269(+) TCAAGC/TCCACT 5 -- int10--------
    rs1476032921,2
    		--109687290(+) GAACA-/TTAATT 5 -- int10--------
    rs1157509851,2
    		F,--109687370(+) TAGTTC/ATTGGT 5 -- int11Minor allele frequency- A:0.04WA 118
    rs743364441,2
    		F,--109687436(+) AGATTA/GTAAAA 5 -- int12Minor allele frequency- G:0.04WA EA 238
    rs1874474821,2
    		--109687448(+) CAAGAC/TAGTAT 5 -- int10--------
    rs1437493241,2
    		--109687484(+) ACAGCA/GTAATT 5 -- int10--------
    rs737627091,2
    		C,--109687529(+) CTCCCA/TCAAGT 5 -- int14Minor allele frequency- T:0.34WA CSA 123
    rs1481423821,2
    		--109687594(+) GAACAC/TGTGCC 5 -- int10--------
    rs1928087121,2
    		--109687775(+) ATTGGC/TTTTGC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for CD164 (109687717 - 109703762 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD164: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD164
    DNA2.0 Custom Variant and Variant Library Synthesis for CD164

    Disorders / Diseases
    for CD164 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD164 for disorders           About GeneDecksing

    OMIM gene information: 603356    OMIM disorders: --

    10 diseases for CD164:    About MalaCards
    bruton-type agammaglobulinemia    bone marrow cancer    agammaglobulinemia    hematopoiesis
    prostate cancer    carcinoma    prostatitis    thyroiditis
    adenocarcinoma    pancreatitis

    3 Novoseek disease relationships for CD164 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric carcinoma 49.7 3 10491205 (1), 10620506 (1)
    metastasis 0 2 16859559 (2)
    carcinoma 0 1 10833281 (1)


    Export disorders for CD164 gene to outside databases

    Publications
    for CD164 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD164 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CD164)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. (PubMed id 9763543)1, 2, 3, 9 Zannettino A.C.W....Simmons P.J. (1998)
    2. CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. (PubMed id 10878358)1, 2, 9 Doyonnas R....Watt S.M. (2000)
    3. The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis. (PubMed id 16859559)1, 2, 9 Havens A.M.... Taichman R.S. (2006)
    4. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. (PubMed id 9680353)1, 3, 9 Watt S.M....Butler L.H. (1998)
    5. A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. (PubMed id 1478919)1, 2, 9 Masuzawa Y.... Muramatsu T. (1992)
    6. Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells. (PubMed id 17077324)1, 2, 9 Forde S....Watt S.M. (2007)
    7. Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. (PubMed id 11027692)1, 2, 9 Chan J.Y.... Watt S.M. (2001)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation. (PubMed id 16924678)1, 9 Zhou G.Q....Watt S.M. (2006)
    10. Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. (PubMed id 10491205)1, 9 Kurosawa N....Muramatsu T. (1999)

    External Searches for CD164 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD164 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8763 HGNC: 1632 AceView: CD164 Ensembl:ENSG00000135535 euGenes: HUgn8763
    ECgene: CD164 Kegg: 8763 H-InvDB: CD164

    Other Databases showing CD164 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD164 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD164 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD164 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD164 gene:
    Search GeneIP for patents involving CD164

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CD164 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD164 (CD164)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CD164  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD164   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD164  
     OriGene Protein Over-expression Lysate for CD164   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CD164   OriGene 3'-UTR Clone for CD164  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD164   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD164  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CD164   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD164   OriGene Custom Protein Services for CD164  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD164
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD164
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD164
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD164
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD164
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD164
     GenScript Custom Purified and Recombinant Proteins Services for CD164 GenScript cDNA clones with any tag delivered in your preferred vector for CD164
     GenScript Custom Assay Services for CD164 GenScript Custom Superior Antibodies Services for CD164
     GenScript Custom overexpressing Cell Line Services for CD164 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD164 promoter
     Search Chromatin IP Primers for CD164
     RT2 qPCR Primer Assay in human, mouse, rat CD164
     Search GNC Networks for CD164
     SABiosciences PCR Arrays including human, mouse, rat CD164
     Search Tocris compounds for CD164
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD164 antibodies
     CD164 proteins
     CD164 lysates
     Search for Antibodies for CD164 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CD164
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CD164 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CD164
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD164
     SwitchGear 3'UTR luciferase reporter plasmids for CD164
     SwitchGear Promoter luciferase reporter plasmids for CD164
     Search ThermoFisher Antibodies for CD164
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD164
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CD164 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4