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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD163L1 Gene

protein-coding GIFtS: 46
GCID: GC12M007507

CD163 molecule-like 1

(Previous name: CD163 antigen-like 1 )

Explore 2 diseases affiliated with
CD163L1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD163 Molecule-Like 1¹ ²		CD163 Antigen B²
CD163B¹ ² ³ ⁵		Scavenger Receptor Cysteine-Rich Type 1 Protein M160²
M160¹ ² ³ ⁵		CD163b Antigen³
CD163 Antigen-Like 1¹ ² ³		CD164L1⁵

External Ids:	HGNC: 30375¹	Entrez Gene: 283316²	Ensembl: ENSG00000177675⁷	OMIM: 606079⁵	UniProtKB: Q9NR16³

Export aliases for CD163L1 gene to outside databases

Previous GC identifer: GC12M007399

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD163L1:

This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are

secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is

defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The

encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternatively spliced

transcript variants encoding different isoforms have been described but their full-length nature has not been

determined. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD163L1 gene promoter:
MZF-1 FOXO1a Evi-1 GATA-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD163L1 promoter sequence

Search SABiosciences Chromatin IP Primers for CD163L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD163L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

CD163L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD163L1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M007507: view genomic region (about GC identifiers)

Start:	7,499,281 bp from pter	End:	7,632,493 bp from pter
Size:	133,213 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C163B_HUMAN, Q9NR16 (See protein sequence)

Recommended Name: Scavenger receptor cysteine-rich type 1 protein M160 precursor

Size: 1453 amino acids; 159239 Da

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable)

Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable)

Subcellular location: Isoform 3: Secreted (Probable)

Secondary accessions: C9JHR7 Q6UWC2

Alternative splicing: 3 isoforms: Q9NR16-1 Q9NR16-2 Q9NR16-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD163L1: NX_Q9NR16

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NR16

CD163L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_777601.2

ENSEMBL proteins:

ENSP00000438217 ENSP00000315945 ENSP00000393474 ENSP00000443004 ENSP00000439921

ENSP00000442328 ENSP00000379871

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

CD163L1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD163L1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001190 Srcr_rcpt

IPR017448 Srcr_rcpt-rel

Graphical View of Domain Structure for InterPro Entry Q9NR16

ProtoNet protein and cluster: Q9NR16

UniProtKB/Swiss-Prot: C163B_HUMAN, Q9NR16

Similarity: Contains 12 SRCR domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005044	scavenger receptor activity	IEA	--

CD163L1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CD163L1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD163L1
Search CenterWatch for drugs/clinical trials and news about CD163L1 / C163B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CD163L1 gene:

NM_174941.4

Unigene Cluster for CD163L1:

CD163 molecule-like 1

Hs.631727 [show with all ESTs]

Unigene Representative Sequence: AK303372

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000539726 ENST00000542055 ENST00000543841 ENST00000313599(uc001qsy.3)

ENST00000416109(uc010sge.2) ENST00000546182 ENST00000545597 ENST00000544331

ENST00000545926 ENST00000543276 ENST00000396630

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Additional cDNA sequence:

AF264014.1 AK058038.1 AK303372.1 BC104962.1 BC104964.1 GQ397482.1

3 DOTS entries:

DT.208793 DT.100756478 DT.100705440

24/38 AceView cDNA sequences (see all 38):

BQ024006 BF792807 BQ776070 W42792 NM_174941 AK058038 AA582301 AL529439

BQ882211 AI278132 BV177491 AF264014 BG570972 AI095706 BF132072 AI609329

BX355217 BV167606 CA428959 BX092497 AI738432 AI090561 W42886 AI288981

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CD163L1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:											-
SP2:															-

ECgene alternative splicing isoforms for CD163L1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD163L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGTGAAGA

About this image

CD163L1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD163L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD163L1

SOURCE GeneReport for Unigene cluster: Hs.631727

UniProtKB/Swiss-Prot: C163B_HUMAN, Q9NR16

Tissue specificity: Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly

expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is

restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD163L1 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	LOC100536480¹	deleted in malignant brain tumors 1 protein-like	51.62(n) 38.98(a)		100536480 XM_003198251.1 XP_003198299.1
fruit fly (Drosophila melanogaster)	Insecta	lox⁶	lysyl oxidase-like	9(a)	possible ortholog	3R(27284102-27285591)

ENSEMBL Gene Tree for CD163L1 (if available)
TreeFam Gene Tree for CD163L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD163L1 gene

LOXL2² CD6² LOXL4² LOXL3² CD163² SSC5D² PRSS12² CD5L²

LOX² SRCRB4D² LOC619207² LOXL1²

6 SIMAP similar genes for CD163L1 using alignment to 8 protein entries: C163B_HUMAN (see all proteins):

CD163 LOXL2 LGALS3BP CD5L CD6 DMBT1

CD163L1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77043948^1,2	F,	--	7507073(+)	`AATTAC/TACTAA`	1	--	ds500¹		1		EA	120
rs141654991^1,2		--	7507089(+)	`ACTACA/GAGAAC`	1	--	ds500¹		0	--	--	--	--
rs115517944^1,2		--	7507284(+)	`AGATCA/GGGGTG`	1	--	ds500¹		0	--	--	--	--
rs191106212^1,2		--	7507426(+)	`CATGAA/GGGCTT`	1	--	ds500¹		0	--	--	--	--
rs182764542^1,2		--	7507446(+)	`GACATA/GATTAC`	1	--	ds500¹		0	--	--	--	--
rs6488177^1,2	C,F,H,	--	7507461(+)	`CCAAAG/ACTCCA`	1	--	ds500¹		16		NS NA WA CSA EA	918
rs150576723^1,2		--	7507655(+)	`TTTTCC/TATAGG`	1	--	ut3¹		0	--	--	--	--
rs1129728^1,2	C,F,A,H,	--	7507657(-)	`GCCCTA/GTGGAA`	1	--	ut3¹ ese³		18		NS EA NA CSA WA	2341
rs8815^1,2	C,F,H,	--	7507726(+)	`GTTGAT/GCTGAA`	1	--	ut3¹		22		NS EA NA	2540
rs139976787^1,2		--	7507834(+)	`ACACAA/CACACA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD163L1 (7499281 - 7632493 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD163L1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD163L1 for disorders           About GeneDecksing

OMIM gene information: 606079    OMIM disorders: --

2 diseases for CD163L1:    About MalaCards

hepatitis b hepatitis

Human Genome Epidemiology (HuGE) Navigator: CD163L1 (2 documents)

Export disorders for CD163L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD163L1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CD163L1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. (PubMed id 11086079)^{1, 2, 3} Gronlund J....Holmskov U. (2000)
Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. (PubMed id 11124526)^{1, 3, 9} Stover C.M....Holmskov U. (2000)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus. (PubMed id 20032174)¹ Van Gorp H....Nauwynck H.J. (2009)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283316	HGNC: 30375	AceView: M160	Ensembl:ENSG00000177675	euGenes: HUgn283316
ECgene: CD163L1	H-InvDB: CD163L1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD163L1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CD163L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD163L1 gene:
Search GeneIP for patents involving CD163L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD163L1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD163L1
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	OriGene siRNA for CD163L1		OriGene 3'-UTR Clone for CD163L1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD163L1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD163L1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CD163L1		OriGene Custom Protein Services for CD163L1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD163L1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD163L1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD163L1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD163L1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD163L1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD163L1

	GenScript Custom Purified and Recombinant Proteins Services for CD163L1		GenScript cDNA clones with any tag delivered in your preferred vector for CD163L1
	GenScript Custom Assay Services for CD163L1		GenScript Custom Superior Antibodies Services for CD163L1
	GenScript Custom overexpressing Cell Line Services for CD163L1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD163L1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CD163L1 Gene

CD163 molecule-like 1

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CD163L1 Gene

CD163 molecule-like 1

Aliasesfor CD163L1 gene

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Genomic Viewsfor CD163L1 gene

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