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Aliases for CD163L1 Gene

Aliases for CD163L1 Gene

  • CD163 Molecule-Like 1 2 3
  • CD163 Antigen-Like 1 2 3 4
  • CD163B 3 4 6
  • M160 3 4 6
  • Scavenger Receptor Cysteine-Rich Type 1 Protein M160 3
  • CD163 Antigen B 3
  • CD163b Antigen 4
  • CD164L1 6

External Ids for CD163L1 Gene

Summaries for CD163L1 Gene

Entrez Gene Summary for CD163L1 Gene

  • This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD163L1 Gene

CD163L1 (CD163 Molecule-Like 1) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD163L1 Gene

Genomics for CD163L1 Gene

Genomic Location for CD163L1 Gene

Start:
7,346,685 bp from pter
End:
7,479,897 bp from pter
Size:
133,213 bases
Orientation:
Minus strand

Genomic View for CD163L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD163L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD163L1 Gene

Regulatory Elements for CD163L1 Gene

Proteins for CD163L1 Gene

  • Protein details for CD163L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR16-C163B_HUMAN
    Recommended name:
    Scavenger receptor cysteine-rich type 1 protein M160
    Protein Accession:
    Q9NR16
    Secondary Accessions:
    • B4E0G7
    • C9JHR7
    • E7EVK4
    • Q2M3B7
    • Q6UWC2

    Protein attributes for CD163L1 Gene

    Size:
    1453 amino acids
    Molecular mass:
    159239 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD163L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD163L1 Gene

Proteomics data for CD163L1 Gene at MOPED

Post-translational modifications for CD163L1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn42, Asn78, Asn120, Asn161, Asn334, Asn377, Asn441, Asn548, Asn637, Asn972, Asn1013, Asn1084, Asn1104, Asn1161, Asn1171, Asn1318, and Asn1354

Other Protein References for CD163L1 Gene

No data available for DME Specific Peptides for CD163L1 Gene

Domains for CD163L1 Gene

Protein Domains for CD163L1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

C163B_HUMAN
Domain:
  • Contains 12 SRCR domains.:
    • Q9NR16
genes like me logo Genes that share domains with CD163L1: view

No data available for Gene Families for CD163L1 Gene

Function for CD163L1 Gene

Gene Ontology (GO) - Molecular Function for CD163L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with CD163L1: view

miRNA for CD163L1 Gene

miRTarBase miRNAs that target CD163L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD163L1 Gene

Localization for CD163L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD163L1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD163L1 Gene COMPARTMENTS Subcellular localization image for CD163L1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD163L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD163L1: view

Pathways for CD163L1 Gene

SuperPathways for CD163L1 Gene

No Data Available

Interacting Proteins for CD163L1 Gene

Gene Ontology (GO) - Biological Process for CD163L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006898 receptor-mediated endocytosis IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with CD163L1: view

No data available for Pathways by source for CD163L1 Gene

Transcripts for CD163L1 Gene

Unigene Clusters for CD163L1 Gene

CD163 molecule-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD163L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: -

Relevant External Links for CD163L1 Gene

GeneLoc Exon Structure for
CD163L1
ECgene alternative splicing isoforms for
CD163L1

Expression for CD163L1 Gene

mRNA expression in normal human tissues for CD163L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD163L1 Gene

This gene is overexpressed in Spleen (15.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD163L1 Gene

SOURCE GeneReport for Unigene cluster for CD163L1 Gene Hs.631727

mRNA Expression by UniProt/SwissProt for CD163L1 Gene

Q9NR16-C163B_HUMAN
Tissue specificity: Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.
genes like me logo Genes that share expressions with CD163L1: view

Orthologs for CD163L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD163L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD163L1 36
  • 99.5 (n)
  • 99.38 (a)
CD163L1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 38 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd163l1 37
  • 37 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 32 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21h14.12 37
  • 21 (a)
ManyToMany
Species with no ortholog for CD163L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD163L1 Gene

ENSEMBL:
Gene Tree for CD163L1 (if available)
TreeFam:
Gene Tree for CD163L1 (if available)

Paralogs for CD163L1 Gene

Paralogs for CD163L1 Gene

Selected SIMAP similar genes for CD163L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD163L1: view

Variants for CD163L1 Gene

Sequence variations from dbSNP and Humsavar for CD163L1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8815 -- 7,355,130(+) GTTGA(G/T)CTGAA utr-variant-3-prime, nc-transcript-variant
rs366301 -- 7,426,098(+) atgga(A/C/G)tacta intron-variant
rs2202538 -- 7,425,849(+) aatag(A/G)aaagc intron-variant
rs3905298 -- 7,371,103(-) GTCAC(A/G)TCTTA intron-variant
rs4072796 - 7,396,400(+) TCAGG(C/G)CCCAT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CD163L1 Gene

Variant ID Type Subtype PubMed ID
nsv594 CNV Loss 18451855
nsv595 CNV Insertion 18451855
esv2745488 CNV Deletion 23290073
esv1408895 CNV Insertion 17803354

Relevant External Links for CD163L1 Gene

HapMap Linkage Disequilibrium report
CD163L1
Human Gene Mutation Database (HGMD)
CD163L1

Disorders for CD163L1 Gene

Relevant External Links for CD163L1

Genetic Association Database (GAD)
CD163L1
Human Genome Epidemiology (HuGE) Navigator
CD163L1
genes like me logo Genes that share disorders with CD163L1: view

No data available for UniProtKB/Swiss-Prot for CD163L1 Gene

Publications for CD163L1 Gene

  1. Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. (PMID: 11124526) Stover C.M. … Holmskov U. (Cytogenet. Cell Genet. 2000) 2 3 23
  2. Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. (PMID: 11086079) Groenlund J. … Holmskov U. (J. Immunol. 2000) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus. (PMID: 20032174) Van Gorp H. … Nauwynck H.J. (J. Virol. 2010) 3 4

Products for CD163L1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CD163L1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CD163L1
    • Block miRNA regulation of CD163L1 using miScript Target Protectors

    Sources for CD163L1 Gene

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