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Aliases for CD163L1 Gene

Aliases for CD163L1 Gene

  • CD163 Molecule Like 1 2 3 5
  • CD163 Antigen-Like 1 2 3 4
  • CD163 Molecule-Like 1 2 3
  • CD163B 3 4
  • M160 3 4
  • CD163 Antigen B 3
  • CD163b Antigen 4

External Ids for CD163L1 Gene

Previous GeneCards Identifiers for CD163L1 Gene

  • GC12M007399
  • GC12M007507

Summaries for CD163L1 Gene

Entrez Gene Summary for CD163L1 Gene

  • This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD163L1 Gene

CD163L1 (CD163 Molecule Like 1) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is SSC4D.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD163L1 Gene

Genomics for CD163L1 Gene

Regulatory Elements for CD163L1 Gene

Enhancers for CD163L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD163L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD163L1 Gene

Chromosome:
12
Start:
7,326,484 bp from pter
End:
7,479,897 bp from pter
Size:
153,414 bases
Orientation:
Minus strand

Genomic View for CD163L1 Gene

Genes around CD163L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD163L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD163L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD163L1 Gene

Proteins for CD163L1 Gene

  • Protein details for CD163L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR16-C163B_HUMAN
    Recommended name:
    Scavenger receptor cysteine-rich type 1 protein M160
    Protein Accession:
    Q9NR16
    Secondary Accessions:
    • B4E0G7
    • C9JHR7
    • E7EVK4
    • Q2M3B7
    • Q6UWC2

    Protein attributes for CD163L1 Gene

    Size:
    1453 amino acids
    Molecular mass:
    159239 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD163L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD163L1 Gene

Proteomics data for CD163L1 Gene at MOPED

Post-translational modifications for CD163L1 Gene

  • Glycosylation at Asn 42, Asn 78, Asn 120, Asn 161, Asn 334, Asn 377, Asn 441, Asn 548, Asn 637, Asn 972, Asn 1013, Asn 1084, Asn 1104, Asn 1161, Asn 1171, Asn 1318, and Asn 1354
  • Modification sites at PhosphoSitePlus

Other Protein References for CD163L1 Gene

No data available for DME Specific Peptides for CD163L1 Gene

Domains & Families for CD163L1 Gene

Gene Families for CD163L1 Gene

Protein Domains for CD163L1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NR16

UniProtKB/Swiss-Prot:

C163B_HUMAN :
  • Contains 12 SRCR domains.
Domain:
  • Contains 12 SRCR domains.
genes like me logo Genes that share domains with CD163L1: view

Function for CD163L1 Gene

genes like me logo Genes that share phenotypes with CD163L1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD163L1

CRISPR Products

miRNA for CD163L1 Gene

miRTarBase miRNAs that target CD163L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD163L1 Gene

Localization for CD163L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD163L1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD163L1 Gene COMPARTMENTS Subcellular localization image for CD163L1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD163L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD163L1: view

Pathways & Interactions for CD163L1 Gene

SuperPathways for CD163L1 Gene

No Data Available

Interacting Proteins for CD163L1 Gene

Gene Ontology (GO) - Biological Process for CD163L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with CD163L1: view

No data available for Pathways by source and SIGNOR curated interactions for CD163L1 Gene

Drugs & Compounds for CD163L1 Gene

No Compound Related Data Available

Transcripts for CD163L1 Gene

Unigene Clusters for CD163L1 Gene

CD163 molecule-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD163L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: -

Relevant External Links for CD163L1 Gene

GeneLoc Exon Structure for
CD163L1
ECgene alternative splicing isoforms for
CD163L1

Expression for CD163L1 Gene

mRNA expression in normal human tissues for CD163L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD163L1 Gene

This gene is overexpressed in Spleen (x15.4).

Protein differential expression in normal tissues from HIPED for CD163L1 Gene

This gene is overexpressed in Cervix (18.0), Tonsil (9.5), Lymph node (8.6), and Stomach (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD163L1 Gene



SOURCE GeneReport for Unigene cluster for CD163L1 Gene Hs.631727

mRNA Expression by UniProt/SwissProt for CD163L1 Gene

Q9NR16-C163B_HUMAN
Tissue specificity: Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.
genes like me logo Genes that share expression patterns with CD163L1: view

Primer Products

No data available for Protein tissue co-expression partners for CD163L1 Gene

Orthologs for CD163L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD163L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD163L1 35
  • 99.5 (n)
  • 99.38 (a)
CD163L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 38 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cd163l1 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21h14.12 36
  • 21 (a)
ManyToMany
Species with no ortholog for CD163L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD163L1 Gene

ENSEMBL:
Gene Tree for CD163L1 (if available)
TreeFam:
Gene Tree for CD163L1 (if available)

Paralogs for CD163L1 Gene

Paralogs for CD163L1 Gene

(7) SIMAP similar genes for CD163L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD163L1: view

Variants for CD163L1 Gene

Sequence variations from dbSNP and Humsavar for CD163L1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4072797 - 7,396,413(+) TGCAT(C/T)ACCTG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs4072796 - 7,396,400(+) TCAGG(C/G)CCCAT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs36206713 - 7,374,688(-) ACGAC(A/G)GCTTC nc-transcript-variant, reference, missense
rs35480970 - 7,374,528(-) AGGAA(C/T)GGAGT nc-transcript-variant, reference, missense
rs6488268 - 7,398,426(+) ATGCA(A/T)AGGCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD163L1 Gene

Variant ID Type Subtype PubMed ID
nsv594 CNV Loss 18451855
nsv595 CNV Insertion 18451855
esv2745488 CNV Deletion 23290073
esv1408895 CNV Insertion 17803354

Variation tolerance for CD163L1 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD163L1 Gene

Human Gene Mutation Database (HGMD)
CD163L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD163L1 Gene

Disorders for CD163L1 Gene

Relevant External Links for CD163L1

Genetic Association Database (GAD)
CD163L1
Human Genome Epidemiology (HuGE) Navigator
CD163L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD163L1

No disorders were found for CD163L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD163L1 Gene

Publications for CD163L1 Gene

  1. Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. (PMID: 11086079) Groenlund J. … Holmskov U. (J. Immunol. 2000) 2 3 4 67
  2. Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. (PMID: 11124526) Stover C.M. … Holmskov U. (Cytogenet. Cell Genet. 2000) 2 3 23
  3. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3
  4. Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: implication in atherosclerosis. (PMID: 21159337) BrochAcriou I. … Ninio E. (Atherosclerosis 2011) 3
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3

Products for CD163L1 Gene

Sources for CD163L1 Gene

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