Aliases for CD163L1 Gene
Aliases for CD163L1 Gene
External Ids for CD163L1 Gene
- HGNC: 30375
- Entrez Gene: 283316
- Ensembl: ENSG00000177675
- OMIM: 606079
- UniProtKB: Q9NR16
Previous GeneCards Identifiers for CD163L1 Gene
- GC12M007399
- GC12M007507
Summaries for CD163L1 Gene
-
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for CD163L1 Gene
CD163L1 (CD163 Molecule Like 1) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD163L1 Gene
Genomics for CD163L1 Gene
Regulatory Elements for CD163L1 Gene
Enhancers for CD163L1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G007439 | 1.4 | FANTOM5 ENCODE | 6.8 | +40.0 | 39984 | 1.1 | PKNOX1 ATF1 CREB3L1 ARNT SIN3A ELK1 ZNF263 SP3 YY2 ZNF518A | CD163L1 LOC100419928 PEX5 NANOG PIR47476 |
| GH12G007555 | 1.2 | FANTOM5 Ensembl ENCODE | 6.6 | -76.5 | -76458 | 1.6 | LEF1 ATF1 CEBPG GABPA MEF2D ATF3 EZH2 NFE2L2 | CD163L1 CD163 PEX5 SLC2A3 GC12M007519 |
| GH12G007498 | 0.7 | Ensembl ENCODE | 0.4 | -19.4 | -19404 | 1.8 | JUND ZEB1 | ATN1 CD163 CD163L1 |
| GH12G007460 | 0.7 | ENCODE | 0.4 | +19.1 | 19098 | 0.2 | CTCF ZNF654 HLF MAFG TRIM22 REST RAD21 MAFF ZNF316 SMC3 | CD163L1 LOC100419928 |
| GH12G007500 | 0.5 | Ensembl | 0.3 | -22.5 | -22478 | 4.0 | ZNF600 NFE2 PRDM1 MAFK | ATN1 CD163 CD163L1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CD163L1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD163L1 gene promoter:
Regulatory Element Products
Genomic Location for CD163L1 Gene
- Chromosome:
- 12
- Start:
- 7,326,484 bp from pter
- End:
- 7,479,897 bp from pter
- Size:
- 153,414 bases
- Orientation:
- Minus strand
Genomic View for CD163L1 Gene
Genes around CD163L1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
CD163L1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD163L1 Gene
Proteins for CD163L1 Gene
-
Protein details for CD163L1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NR16-C163B_HUMAN
- Recommended name:
- Scavenger receptor cysteine-rich type 1 protein M160
- Protein Accession:
- Q9NR16
- B4E0G7
- C9JHR7
- E7EVK4
- Q2M3B7
- Q6UWC2
Protein attributes for CD163L1 Gene
- Size:
- 1453 amino acids
- Molecular mass:
- 159239 Da
- Quaternary structure:
- No Data Available
Protein Expression for CD163L1 Gene
Post-translational modifications for CD163L1 Gene
Other Protein References for CD163L1 Gene
Antibody Products
- Novus Biologicals Antibodies for CD163L1
-
Abcam antibodies for CD163L1
- Invitrogen Antibodies for CD163L1
- antibodies-online Antibodies for CD163L1: See all 27
- GeneTex CD163L1 antibody for CD163L1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CD163L1
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- Search GeneTex for Proteins for CD163L1
Assay Products
No data available for DME Specific Peptides for CD163L1 Gene
Domains & Families for CD163L1 Gene
Gene Families for CD163L1 Gene
Protein Domains for CD163L1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD163L1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD163L1 Gene
Function for CD163L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005044 | scavenger receptor activity | IEA | -- |
Phenotypes for CD163L1 Gene
- GenomeRNAi human phenotypes for CD163L1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability ratio
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Model Products
-
Taconic Biosciences Mouse Models for CD163L1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD163L1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD163L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD163L1 gene
- Search ViGene Biosciences for CD163L1
CRISPR Products
-
OriGene CRISPR knockouts for CD163L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD163L1
- GenScript: Design CRISPR guide RNA sequences for CD163L1
miRNA for CD163L1 Gene
- miRTarBase miRNAs that target CD163L1
miRNA Products
- Search ViGene Biosciences for CD163L1
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CD163L1
- Browse OriGene Inhibitory RNA Products For CD163L1
-
ViGene Biosciences ready-to-package AAV shRNAs for CD163L1 gene
Clone Products
-
OriGene ORF clones in human for CD163L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD163L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD163L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CD163L1
-
ViGene Biosciences adenoviral particle packaged cDNA for CD163L1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD163L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD163L1 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD163L1 Gene
Localization for CD163L1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD163L1 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CD163L1 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006898 | receptor-mediated endocytosis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CD163L1 Gene
Transcripts for CD163L1 Gene
mRNA/cDNA for CD163L1 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD163L1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD163L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD163L1
- GenScript: Design CRISPR guide RNA sequences for CD163L1
miRNA Products
- Search ViGene Biosciences for CD163L1
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CD163L1
- Browse OriGene Inhibitory RNA Products For CD163L1
-
ViGene Biosciences ready-to-package AAV shRNAs for CD163L1 gene
Clone Products
-
OriGene ORF clones in human for CD163L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD163L1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD163L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD163L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - |
Expression for CD163L1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for CD163L1 Gene
This gene is overexpressed in Spleen (x15.4).
This gene is overexpressed in Cervix (18.0), Tonsil (9.5), Lymph node (8.6), and Stomach (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD163L1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD163L1 Gene:
CD163L1SOURCE GeneReport for Unigene cluster for CD163L1 Gene:
Hs.631727mRNA Expression by UniProt/SwissProt for CD163L1 Gene:
Q9NR16-C163B_HUMAN
Tissue specificity:
Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.
Evidence on tissue expression from TISSUES for CD163L1 Gene
- Heart(4.2)
- Liver(4.1)
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for CD163L1
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD163L1 Gene
Orthologs for CD163L1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD163L1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Cd163l1 35 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-21h14.12 35 |
|
ManyToMany |
- Species where no ortholog for CD163L1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CD163L1 Gene
Paralogs for CD163L1 Gene
(7) SIMAP similar genes for CD163L1 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for CD163L1 Gene
Variants for CD163L1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000024526 | -- | 7,383,090(+) | ATGAG(C/T)CTTCA | intron-variant | |
| rs1000025490 | -- | 7,428,315(+) | TTAGT(A/G)TGAAA | intron-variant | |
| rs1000025764 | -- | 7,358,403(+) | AAATA(C/T)TGTGT | intron-variant | |
| rs1000034712 | -- | 7,340,724(+) | GAGGA(C/G)TATCT | intron-variant | |
| rs1000089357 | -- | 7,366,241(+) | AGGCC(-/GGAAAGGGTAGG)GGAAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1408895 | CNV | insertion | 17803354 |
| esv2745488 | CNV | deletion | 23290073 |
| nsv1115967 | CNV | insertion | 24896259 |
| nsv1116690 | CNV | tandem duplication | 24896259 |
| nsv1122690 | CNV | deletion | 24896259 |
| nsv1148558 | CNV | duplication | 26484159 |
| nsv594 | CNV | deletion | 18451855 |
| nsv595 | CNV | insertion | 18451855 |
| nsv976561 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.14;
69.39% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CD163L1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD163L1 Gene
Disorders for CD163L1 Gene
Relevant External Links for CD163L1
No disorders were found for CD163L1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD163L1 Gene
Publications for CD163L1 Gene
- Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. (PMID: 11086079) Groenlund J. … Holmskov U. (J. Immunol. 2000) 2 3 4 64
- Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. (PMID: 11124526) Stover C.M. … Holmskov U. (Cytogenet. Cell Genet. 2000) 2 3 22 64
- Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus. (PMID: 20032174) Van Gorp H. … Nauwynck H.J. (J. Virol. 2010) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
Products for CD163L1 Gene
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- Humanized Mice
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- Horizon Cell Lines for CD163L1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD163L1
- VectorBuilder custom plasmid, inducible vectors for CD163L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD163L1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CD163L1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (50) eBioscience
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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