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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD163 Gene

protein-coding GIFtS: 60
GCID: GC12M007623

CD163 molecule

(Previous name: CD163 antigen )

Explore 54 diseases affiliated with
CD163 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD163 Molecule¹ ²		Hemoglobin Scavenger Receptor² ³
M130¹ ² ³		Macrophage-Associated Antigen²
MM130¹ ²		Scavenger Receptor Cysteine-Rich Type 1 Protein M130²
CD163 Antigen¹ ³

External Ids:	HGNC: 1631¹	Entrez Gene: 9332²	Ensembl: ENSG00000177575⁷	OMIM: 605545⁵	UniProtKB: Q86VB7³

Export aliases for CD163 gene to outside databases

Previous GC identifers: GC12U990123 GC12M007759 GC12M007523 GC12M007516 GC12M007517 GC12M007518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD163:

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is

exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the

clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from

free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and

inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been

described for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7

Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by

macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the

uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds

hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for

complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric

haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent

calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher

capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells

Function: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable

diagnostic parameter for monitoring macrophage activation in inflammatory conditions

Gene Wiki entry for CD163

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD163 gene promoter:
NF-YA NF-kappaB CBF-C CBF-A CBF-B CP1A CP1C NF-Y NF-kappaB1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD163 promoter sequence

Search SABiosciences Chromatin IP Primers for CD163

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD163

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

CD163 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD163 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M007623: view genomic region (about GC identifiers)

Start:	7,623,409 bp from pter	End:	7,656,489 bp from pter
Size:	33,081 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7 (See protein sequence)

Recommended Name: Scavenger receptor cysteine-rich type 1 protein M130 precursor

Size: 1156 amino acids; 125451 Da

Subunit: Interacts with CSNK2B

Subcellular location: Soluble CD163: Secreted

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower

surface expression when expressed in cells

Miscellaneous: Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces

metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the

membrane-bound form on circulating monocytes

Miscellaneous: The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and

monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of

the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the

inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for

evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease,

transplantation, atherosclerosis and cancer

Caution: It is uncertain whether Met-1 or Met-6 is the initiator

Sequence caution: Sequence=CAA80541.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAA80542.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA80543.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA80544.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAB45233.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: C9JIG2 Q07898 Q07899 Q07900 Q07901 Q2VLH7

Alternative splicing: 4 isoforms: Q86VB7-1 Q86VB7-2 Q86VB7-3 Q86VB7-4

Explore the universe of human proteins at neXtProt for CD163: NX_Q86VB7

Post-translational modifications:

A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester

and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be

blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus

probably induced by membrane-bound metalloproteinases ADAMs¹

Phosphorylated (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86VB7

CD163 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004235.4 NP_981961.2

ENSEMBL proteins:

ENSP00000352071 ENSP00000445438 ENSP00000439226 ENSP00000444071 ENSP00000379863

ENSP00000403885

Reactome Protein details: Q86VB7
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD163
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD163 OriGene Protein Over-expression Lysate: CD163 OriGene Custom Protein Services for CD163
	GenScript Custom Purified and Recombinant Proteins Services for CD163
	Novus Biologicals CD163 Protein Novus Biologicals CD163 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CD163
	Uscn Proteins for CD163

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005887	integral to plasma membrane	TAS	8370408
GO:0016020	membrane	--	--

CD163 for ontologies About GeneDecksing

CD163 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD163
	OriGene Antibodies (see all 12): CD163 OriGene Custom Antibody Services for CD163
	GenScript Custom Superior Antibodies Services for CD163
	Novus Biologicals CD163 Antibodies
	Search for Antibodies for CD163 at Abcam
	Uscn Antibodies for CD163
	ThermoFisher Antibodies for CD163

Assay Products for CD163:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CD163 (see all)
	GenScript Custom Assay Services for CD163
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD163

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD163 for domains About GeneDecksing

2 InterPro domains/families:

IPR001190 Srcr_rcpt

IPR017448 Srcr_rcpt-rel

Graphical View of Domain Structure for InterPro Entry Q86VB7

ProtoNet protein and cluster: Q86VB7

UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7

Domain: The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes

Similarity: Contains 9 SRCR domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: