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Aliases for CD163 Gene

Aliases for CD163 Gene

  • CD163 Molecule 2 3
  • Hemoglobin Scavenger Receptor 3 4
  • CD163 Antigen 2 4
  • M130 3 4
  • Scavenger Receptor Cysteine-Rich Type 1 Protein M130 3
  • Macrophage-Associated Antigen 3
  • MM130 3

External Ids for CD163 Gene

Summaries for CD163 Gene

Entrez Gene Summary for CD163 Gene

  • The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD163 Gene

CD163 (CD163 Molecule) is a Protein Coding gene. Diseases associated with CD163 include adult xanthogranuloma and rosai-dorfman disease. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for CD163 Gene

  • Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells

  • After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions

Gene Wiki entry for CD163 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD163 Gene

Genomics for CD163 Gene

Genomic Location for CD163 Gene

Start:
7,470,813 bp from pter
End:
7,503,893 bp from pter
Size:
33,081 bases
Orientation:
Minus strand

Genomic View for CD163 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD163 Gene

Regulatory Elements for CD163 Gene

Proteins for CD163 Gene

  • Protein details for CD163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VB7-C163A_HUMAN
    Recommended name:
    Scavenger receptor cysteine-rich type 1 protein M130
    Protein Accession:
    Q86VB7
    Secondary Accessions:
    • C9JIG2
    • Q07898
    • Q07899
    • Q07900
    • Q07901
    • Q2VLH7

    Protein attributes for CD163 Gene

    Size:
    1156 amino acids
    Molecular mass:
    125451 Da
    Quaternary structure:
    • Interacts with CSNK2B.
    Miscellaneous:
    • Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes
    • The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the alternative macrophage activation phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer
    SequenceCaution:
    • Sequence=CAA80541.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80544.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB45233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CD163 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD163 Gene

Proteomics data for CD163 Gene at MOPED

Post-translational modifications for CD163 Gene

  • A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn105, Asn140, Asn767, and Asn1027

Other Protein References for CD163 Gene

No data available for DME Specific Peptides for CD163 Gene

Domains for CD163 Gene

Gene Families for CD163 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD163 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

C163A_HUMAN
Domain:
  • The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.:
    • Q86VB7
  • Contains 9 SRCR domains.:
    • Q86VB7
genes like me logo Genes that share domains with CD163: view

Function for CD163 Gene

Molecular function for CD163 Gene

GENATLAS Biochemistry: macrophage associated antigen,involved in myeloid specific gene expression,including several alternatively spliced isoforms,SRCR superfamily
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype {ECO:0000269 PubMed:11196644}; KM=0.2 nM for hemoglobin/haptoglobin of HP*1F phenotype {ECO:0000269 PubMed:11196644};
UniProtKB/Swiss-Prot Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells
UniProtKB/Swiss-Prot Function: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions
UniProtKB/Swiss-Prot Induction: Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.

Gene Ontology (GO) - Molecular Function for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity NAS 8370408
GO:0005515 protein binding IPI 15479433
genes like me logo Genes that share ontologies with CD163: view

Phenotypes for CD163 Gene

GenomeRNAi human phenotypes for CD163:
genes like me logo Genes that share phenotypes with CD163: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD163 Gene

Localization for CD163 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD163 Gene

Soluble CD163: Secreted.
Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD163 Gene COMPARTMENTS Subcellular localization image for CD163 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8370408
GO:0016020 membrane --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with CD163: view

Pathways for CD163 Gene

genes like me logo Genes that share pathways with CD163: view

Pathways by source for CD163 Gene

Interacting Proteins for CD163 Gene

Gene Ontology (GO) - Biological Process for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006953 acute-phase response IEA --
genes like me logo Genes that share ontologies with CD163: view

Compounds for CD163 Gene

(3) HMDB Compounds for CD163 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6

(5) Novoseek inferred chemical compound relationships for CD163 Gene

Compound -log(P) Hits PubMed IDs
mannose 21.8 3
dexamethasone 21.3 6
paraffin 12.4 3
iron 8.69 2
lipid 0 1
genes like me logo Genes that share compounds with CD163: view

Transcripts for CD163 Gene

Unigene Clusters for CD163 Gene

CD163 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD163 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD163 Gene

GeneLoc Exon Structure for
CD163
ECgene alternative splicing isoforms for
CD163

Expression for CD163 Gene

mRNA expression in normal human tissues for CD163 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD163 Gene

This gene is overexpressed in Whole Blood (7.6), Adipose - Visceral (Omentum) (4.5), and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD163 Gene

SOURCE GeneReport for Unigene cluster for CD163 Gene Hs.504641

mRNA Expression by UniProt/SwissProt for CD163 Gene

Q86VB7-C163A_HUMAN
Tissue specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
genes like me logo Genes that share expressions with CD163: view

Orthologs for CD163 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD163 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD163 36
  • 98.82 (n)
  • 98.27 (a)
CD163 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD163 36
  • 85.07 (n)
  • 82.96 (a)
CD163 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD163 36
  • 86.97 (n)
  • 84.47 (a)
CD163 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd163 36
  • 78.36 (n)
  • 73.67 (a)
Cd163 16
Cd163 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd163 36
  • 78.41 (n)
  • 74.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 34 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-161n3.4 37
  • 28 (a)
ManyToMany
si:ch211-161n3.5 37
  • 32 (a)
ManyToMany
si:dkey-21h14.10 37
  • 35 (a)
ManyToMany
si:dkey-21h14.11 37
  • 34 (a)
ManyToMany
si:dkey-21h14.14 37
  • 36 (a)
ManyToMany
si:dkey-21h14.8 37
  • 33 (a)
ManyToMany
si:dkey-21h14.9 37
  • 35 (a)
ManyToMany
Species with no ortholog for CD163:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD163 Gene

ENSEMBL:
Gene Tree for CD163 (if available)
TreeFam:
Gene Tree for CD163 (if available)

Paralogs for CD163 Gene

Paralogs for CD163 Gene

Selected SIMAP similar genes for CD163 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CD163: view

Variants for CD163 Gene

Sequence variations from dbSNP and Humsavar for CD163 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs593866 -- 7,474,741(-) atctc(C/G)tttag intron-variant
rs678912 -- 7,474,735(-) ttcag(C/T)tctgc intron-variant
rs1130416 -- 7,470,985(-) aattt(A/T)ttttt utr-variant-3-prime, downstream-variant-500B
rs3210140 -- 7,502,541(-) TCAAC(C/T)TGAGT synonymous-codon, reference, nc-transcript-variant
rs4883263 - 7,496,888(+) CCAGA(C/T)AGCAG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CD163 Gene

Variant ID Type Subtype PubMed ID
nsv525458 CNV Loss 19592680
esv267832 CNV Insertion 20981092

Relevant External Links for CD163 Gene

HapMap Linkage Disequilibrium report
CD163
Human Gene Mutation Database (HGMD)
CD163

Disorders for CD163 Gene

(1) University of Copenhagen DISEASES for CD163 Gene

(18) Novoseek inferred disease relationships for CD163 Gene

Disease -log(P) Hits PubMed IDs
rosai-dorfman disease 66.4 2
histiocytoma fibrous 61.5 7
spondylarthropathies 45.3 1
hemolysis 44.6 1
inflammation 44.5 13

Relevant External Links for CD163

Genetic Association Database (GAD)
CD163
Human Genome Epidemiology (HuGE) Navigator
CD163
genes like me logo Genes that share disorders with CD163: view

No data available for UniProtKB/Swiss-Prot for CD163 Gene

Publications for CD163 Gene

  1. Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. (PMID: 10403791) Ritter M. … Schmitz G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. (PMID: 10648003) Buechler C. … Schmitz G. (J. Leukoc. Biol. 2000) 3 4 23
  3. Identification of the haemoglobin scavenger receptor. (PMID: 11196644) Kristiansen M. … Moestrup S.K. (Nature 2001) 3 4 23
  4. Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP- 3. (PMID: 12296867) Matsushita N. … Matsuyama T. (Clin. Exp. Immunol. 2002) 3 4 23
  5. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. (PMID: 12377940) Hintz K.A. … Guyre P.M. (J. Leukoc. Biol. 2002) 3 4 23

Products for CD163 Gene

Sources for CD163 Gene

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