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CD163 Gene

protein-coding   GIFtS: 64
GCID: GC12M007623

CD163 Molecule

(Previous name: CD163 antigen)
  See CD163-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD163 Molecule1 2     MM1302
CD163 Antigen1 3     Macrophage-Associated Antigen2
Hemoglobin Scavenger Receptor2 3     Scavenger Receptor Cysteine-Rich Type 1 Protein M1302
M1302 3     

External Ids:    HGNC: 16311   Entrez Gene: 93322   Ensembl: ENSG000001775757   OMIM: 6055455   UniProtKB: Q86VB73   

Export aliases for CD163 gene to outside databases

Previous GC identifers: GC12U990123 GC12M007759 GC12M007523 GC12M007516 GC12M007517 GC12M007518


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD163 Gene:
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is
exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in
the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues
from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for
bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms
have been described for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CD163 Gene:
CD163 (CD163 molecule) is a protein-coding gene. Diseases associated with CD163 include adult xanthogranuloma, and necrobiosis lipoidica. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7
Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes
by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in
the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme.
Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity
for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and
dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine
kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3
exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in
cells
Function: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable
diagnostic parameter for monitoring macrophage activation in inflammatory conditions

Gene Wiki entry for CD163 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD163 gene promoter:
         NF-YA   NF-kappaB   CBF-C   CBF-A   CBF-B   CP1A   CP1C   NF-Y   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD163 promoter sequence
   Search Chromatin IP Primers for CD163

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD163


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD163 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD163 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007623:  view genomic region     (about GC identifiers)

Start:
7,623,409 bp from pter      End:
7,656,489 bp from pter
Size:
33,081 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7 (See protein sequence)
Recommended Name: Scavenger receptor cysteine-rich type 1 protein M130 precursor  
Size: 1156 amino acids; 125451 Da
Subunit: Interacts with CSNK2B
Miscellaneous: Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it
induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases
expression of the membrane-bound form on circulating monocytes
Miscellaneous: The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function
and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of
macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major
role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a
number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g.
infection, autoimmune disease, transplantation, atherosclerosis and cancer
Caution: It is uncertain whether Met-1 or Met-6 is the initiator
Sequence caution: Sequence=CAA80541.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA80542.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA80543.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA80544.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAB45233.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: C9JIG2 Q07898 Q07899 Q07900 Q07901 Q2VLH7
Alternative splicing: 4 isoforms:  Q86VB7-1   Q86VB7-2   Q86VB7-3   Q86VB7-4   

Explore the universe of human proteins at neXtProt for CD163: NX_Q86VB7

Explore proteomics data for CD163 at MOPED

Post-translational modifications: 

  • A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol
    ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases
    and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase
    TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs1
  • Phosphorylated (Probable)1
  • Glycosylation2 at Asn105, Asn140, Asn767, Asn1027
  • Modification sites at PhosphoSitePlus

  • See CD163 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004235.4  NP_981961.2  

    ENSEMBL proteins: 
     ENSP00000352071   ENSP00000445438   ENSP00000439226   ENSP00000444071   ENSP00000379863  
     ENSP00000403885  
    Reactome Protein details: Q86VB7

    CD163 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CD163

     
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    CD163 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR001190 SRCR
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry Q86VB7

    ProtoNet protein and cluster: Q86VB7

    UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7
    Domain: The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes
    Similarity: Contains 9 SRCR domains


    Find genes that share domains with CD163           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C163A_HUMAN, Q86VB7
    Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes
    by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in
    the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme.
    Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity
    for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and
    dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine
    kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3
    exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in
    cells
    Function: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable
    diagnostic parameter for monitoring macrophage activation in inflammatory conditions
    Biophysicochemical properties: Kinetic parameters: KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype; KM=0.2
    nM for hemoglobin/haptoglobin of HP*1F phenotype;
    Induction: Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and
    interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS),
    IFNG/IFN-gamma and TNF

         Genatlas biochemistry entry for CD163:
    macrophage associated antigen,involved in myeloid specific gene expression,including several alternatively spliced
    isoforms,SRCR superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity NAS8370408
    GO:0005515protein binding IPI15479433
         
    Find genes that share ontologies with CD163           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD163:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD163
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD163
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    miRNA
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    hsa-miR-4291 hsa-miR-181c hsa-miR-15a hsa-miR-340 hsa-miR-3680 hsa-miR-424 hsa-miR-4274 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCD163 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CD163
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C163A_HUMAN, Q86VB7: Soluble CD163: Secreted
    C163A_HUMAN, Q86VB7: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a
    lower surface expression when expressed in cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8370408
    GO:0016020membrane ----
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with CD163           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD163 About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53


    Find genes that share SuperPaths with CD163           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD163
        Scavenging of heme from plasma


        Pathway & Disease-focused RT2 Profiler PCR Array including CD163: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD163

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CD163 (Q86VB73 ENSP000003520714) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    ENSG00000228875P678703I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis NAS8370408
    GO:0006953acute-phase response IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD163 (C163A)

    3 HMDB Compounds for CD163    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    5 Novoseek inferred chemical compound relationships for CD163 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 21.8 3 15362365 (1), 18042719 (1), 16112744 (1)
    dexamethasone 21.3 11 10725797 (2), 11985517 (1), 12358930 (1), 17490617 (1) (see all 5)
    paraffin 12.4 3 15491976 (2), 18563432 (1)
    iron 8.69 2 11854028 (1), 19574425 (1)
    lipid 0 1 19556258 (1)



    Find genes that share compounds with CD163           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD163 gene (2 alternative transcripts): 
    NM_004244.5  NM_203416.3  

    Unigene Cluster for CD163:

    CD163 molecule
    Hs.504641  [show with all ESTs]
    Unigene Representative Sequence: NM_004244
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359156(uc001qsz.3 uc001qta.3 uc009zfw.2) ENST00000537044
    ENST00000542705 ENST00000534848 ENST00000542280 ENST00000537626 ENST00000541972
    ENST00000396620 ENST00000432237 ENST00000538840 ENST00000539632
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    hsa-miR-4291 hsa-miR-181c hsa-miR-15a hsa-miR-340 hsa-miR-3680 hsa-miR-424 hsa-miR-4274 hsa-miR-23a
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    Additional mRNA sequence: 

    AK226017.1 BC051281.1 DQ058615.1 Z22968.1 Z22969.1 

    11 DOTS entries:

    DT.100768793  DT.100768792  DT.100768795  DT.215131  DT.70103475  DT.100695915  DT.100768794  DT.86840847 
    DT.100768796  DT.95285658  DT.95285664 

    Selected AceView cDNA sequences (see all 194):

    R37968 AI699826 AL550207 Z22970 AI129762 R73262 BP343939 BC051281 
    BF435954 AA292877 CB528473 BP344502 BG742112 AW204801 BX483922 CA307531 
    BP345463 AL540905 CA425584 BF939741 BM688448 CA440009 NM_004244 AI051209 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD163    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                                                                                            
    SP2:                                                                                            -               
    SP3:                                                                                                            
    SP4:                                                                                            -               


    ECgene alternative splicing isoforms for CD163

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD163 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCACAACG
    CD163 Expression
    About this image


    CD163 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Hofbauer Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells
     
     Chorion (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    CD163 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD163 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504641

    UniProtKB/Swiss-Prot: C163A_HUMAN, Q86VB7
    Tissue specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp
    macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal
    macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the
    blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform
    detected in the blood

        Pathway & Disease-focused RT2 Profiler PCR Array including CD163: 
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD163 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1631 , 5 CD163 antigen1, 5 78.36(n)1
    73.67(a)1
      6 (59.13 cM)5
    936711  NM_001170395.11  NP_001163866.11 
     1243046515 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    41(a)
    41(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    AADN03013081.1(2463-5190)
    JH376378.1(12420-16398)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-21h14.146
    si:dkey-21h14.106
    (see all 7)
    si:dkey-21h14.10
    (see all 7)
    36(a)
    35(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    4(10135388-10142396) ENSDARG00000096184
    4(10177104-10187162) ENSDARG00000096187


    ENSEMBL Gene Tree for CD163 (if available)
    TreeFam Gene Tree for CD163 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD163 gene
    LOXL22  CD62  CD163L12  LOXL42  LOXL32  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    6 SIMAP similar genes for CD163 using alignment to 7 protein entries:     C163A_HUMAN (see all proteins):
    CD163L1    LGALS3BP    LOXL2    CD5L    FLJ00268    CD6

    Find genes that share paralogs with CD163           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD163 (see all 772)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788322831,2
    F--7438729(+) AGAACA/CCCCAA 2 -- int13Minor allele frequency- C:0.25NA 8
    rs791334211,2
    F--7441585(-) TCACTA/GATTTC 2 -- int13Minor allele frequency- G:0.25NA 8
    rs794754541,2
    C--7442361(-) TGCTGA/GATAGT 2 -- int13Minor allele frequency- G:0.00NA 8
    rs1857252341,2
    C--7507606(+) TGTCAA/GTTAGC 2 -- ds50010--------
    rs1997565441,2
    C--7507838(+) AAATT-/AAAAAA 2 -- ds50010--------
    rs1422720731,2
    C--7507857(+) TTGCAC/TAGAAA 2 -- ds50010--------
    rs730434561,2
    C,F--7507935(+) TTTATG/ATGAAT 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1905601901,2
    --7508063(+) AGAAAC/TGAAAC 2 -- ds50010--------
    rs1457769051,2
    --7508069(+) GAAACC/TACTGA 2 -- ds50010--------
    rs1135909961,2
    C--7508082(+) CTTTGA/C/TGCCCT 4 -- ut311CSA 1

    HapMap Linkage Disequilibrium report for CD163 (7623409 - 7656489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD163:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267832CNV Insertion20981092
    nsv525458CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD163
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605545    OMIM disorders: --

    7 diseases for CD163:    
    About MalaCards
    adult xanthogranuloma    necrobiosis lipoidica    macrophage activation syndrome    rosai-dorfman disease
    pulpitis    spondylarthropathy    histiocytic sarcoma

    1 disease from the University of Copenhagen DISEASES database for CD163:
    Histiocytosis

    Find genes that share disorders with CD163           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD163 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rosai-dorfman disease 66.4 2 15832085 (1), 15491976 (1)
    histiocytoma fibrous 61.5 9 20472850 (4), 16640542 (2), 15832085 (1)
    spondylarthropathies 45.3 1 15146432 (1)
    hemolysis 44.6 1 20153663 (1)
    inflammation 44.5 24 18632918 (2), 11854028 (1), 15136587 (1), 10725797 (1) (see all 12)
    hemangioma 42 2 15832085 (1), 15491976 (1)
    synovitis 38.1 3 12296867 (1), 15146432 (1)
    sarcoma 33.2 3 15832085 (2), 15491976 (1)
    necrosis 26.5 12 15925282 (2), 15362365 (1), 19473660 (1), 20299103 (1) (see all 9)
    tumors 21.5 17 15832085 (3), 15925282 (2), 15362365 (1), 18047662 (1) (see all 12)

    Genetic Association Database (GAD): CD163
    Human Genome Epidemiology (HuGE) Navigator: CD163 (5 documents)

    Export disorders for CD163 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD163 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with CD163)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. (PubMed id 10403791)1, 2, 3, 9 Ritter M.... Schmitz G. (Biochem. Biophys. Res. Commun. 1999)
    2. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. (PubMed id 8370408)1, 2, 3 Law S.K.A.... Mason D.Y. (Eur. J. Immunol. 1993)
    3. Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP- 3. (PubMed id 12296867)1, 2, 9 Matsushita N.... Matsuyama T. (Clin. Exp. Immunol. 2002)
    4. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. (PubMed id 15478309)1, 2, 9 Moestrup S.K. and Moller H.J. (Ann. Med. 2004)
    5. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. (PubMed id 12377940)1, 2, 9 Hintz K.A.... Guyre P.M. (J. Leukoc. Biol. 2002)
    6. Cross-linking of FcgammaR triggers shedding of the hemoglobin- haptoglobin scavenger receptor CD163. (PubMed id 15075364)1, 2, 9 Sulahian T.H.... Guyre P.M. (J. Leukoc. Biol. 2004)
    7. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. (PubMed id 10648003)1, 2, 9 Buechler C.... Schmitz G. (J. Leukoc. Biol. 2000)
    8. Identification of the haemoglobin scavenger receptor. (PubMed id 11196644)1, 2, 9 Kristiansen M.... Moestrup S.K. (Nature 2001)
    9. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9332 HGNC: 1631 AceView: CD163 Ensembl:ENSG00000177575 euGenes: HUgn9332
    ECgene: CD163 H-InvDB: CD163

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD163 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD163 gene:
    Search GeneIP for patents involving CD163

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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