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Aliases for CD163 Gene

Aliases for CD163 Gene

  • CD163 Molecule 2 3 5
  • Hemoglobin Scavenger Receptor 3 4
  • CD163 Antigen 2 4
  • M130 3 4
  • Scavenger Receptor Cysteine-Rich Type 1 Protein M130 3
  • Macrophage-Associated Antigen 3
  • SCARI1 3
  • MM130 3

External Ids for CD163 Gene

Previous GeneCards Identifiers for CD163 Gene

  • GC12U990123
  • GC12M007759
  • GC12M007523
  • GC12M007516
  • GC12M007517
  • GC12M007623

Summaries for CD163 Gene

Entrez Gene Summary for CD163 Gene

  • The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD163 Gene

CD163 (CD163 Molecule) is a Protein Coding gene. Diseases associated with CD163 include Rosai-Dorfman Disease and Non-Langerhans-Cell Histiocytosis. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is CD163L1.

UniProtKB/Swiss-Prot for CD163 Gene

  • Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

  • After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Gene Wiki entry for CD163 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD163 Gene

Genomics for CD163 Gene

Regulatory Elements for CD163 Gene

Enhancers for CD163 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F007555 1.2 FANTOM5 Ensembl ENCODE 4 -52.6 -52630 2.0 MEF2D ATF1 ATF3 GABPA NFE2L2 CD163L1 CD163 PEX5 SLC2A3 GC12M007519 GAPDHP31
GH12F007512 1.2 FANTOM5 Ensembl ENCODE 1.7 -8.9 -8908 0.4 NFIA HLF MIER2 REST ZNF644 RAD21 YY1 JUND ATF3 CEBPA PEX5 SLC2A3 CD163 GC12M007519
GH12F007498 0.2 ENCODE 0.8 +5.0 4968 0.8 JUND ZEB1 CD163 CD163L1
GH12F007496 0.4 ENCODE 0.4 +6.4 6358 1.5 CD163 CD163L1
GH12F007540 1.2 Ensembl ENCODE 0.3 -38.3 -38253 2.5 GATA3 ZNF18 DPPA3 GC12M007519 CD163
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD163 on UCSC Golden Path with GeneCards custom track

Promoters for CD163 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774675 1293 2001 MAFK

Genomic Location for CD163 Gene

Chromosome:
12
Start:
7,470,813 bp from pter
End:
7,503,893 bp from pter
Size:
33,081 bases
Orientation:
Minus strand

Genomic View for CD163 Gene

Genes around CD163 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD163 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD163 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD163 Gene

Proteins for CD163 Gene

  • Protein details for CD163 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VB7-C163A_HUMAN
    Recommended name:
    Scavenger receptor cysteine-rich type 1 protein M130
    Protein Accession:
    Q86VB7
    Secondary Accessions:
    • C9JIG2
    • Q07898
    • Q07899
    • Q07900
    • Q07901
    • Q2VLH7

    Protein attributes for CD163 Gene

    Size:
    1156 amino acids
    Molecular mass:
    125451 Da
    Quaternary structure:
    • Interacts with CSNK2B.
    Miscellaneous:
    • Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes.
    • The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the alternative macrophage activation phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer.
    SequenceCaution:
    • Sequence=CAA80541.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA80544.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB45233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CD163 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD163 Gene

Post-translational modifications for CD163 Gene

  • A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
  • Phosphorylated.
  • Glycosylation at Asn 105, Asn 140, Asn 767, and Asn 1027
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD163

No data available for DME Specific Peptides for CD163 Gene

Domains & Families for CD163 Gene

Gene Families for CD163 Gene

Protein Domains for CD163 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD163 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VB7

UniProtKB/Swiss-Prot:

C163A_HUMAN :
  • The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.
Domain:
  • The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.
  • Contains 9 SRCR domains.
genes like me logo Genes that share domains with CD163: view

Function for CD163 Gene

Molecular function for CD163 Gene

GENATLAS Biochemistry:
macrophage associated antigen,involved in myeloid specific gene expression,including several alternatively spliced isoforms,SRCR superfamily
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype {ECO:0000269 PubMed:11196644}; KM=0.2 nM for hemoglobin/haptoglobin of HP*1F phenotype {ECO:0000269 PubMed:11196644};
UniProtKB/Swiss-Prot Function:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
UniProtKB/Swiss-Prot Function:
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
UniProtKB/Swiss-Prot Induction:
Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.

Gene Ontology (GO) - Molecular Function for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity NAS 8370408
GO:0005515 protein binding IPI 15479433
genes like me logo Genes that share ontologies with CD163: view
genes like me logo Genes that share phenotypes with CD163: view

Animal Model Products

miRNA for CD163 Gene

miRTarBase miRNAs that target CD163

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD163 Gene

Localization for CD163 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD163 Gene

Soluble CD163: Secreted.
Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD163 Gene COMPARTMENTS Subcellular localization image for CD163 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
cytosol 2
lysosome 2
vacuole 2
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8370408
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD163: view

Pathways & Interactions for CD163 Gene

genes like me logo Genes that share pathways with CD163: view

Gene Ontology (GO) - Biological Process for CD163 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CD163: view

No data available for SIGNOR curated interactions for CD163 Gene

Drugs & Compounds for CD163 Gene

(5) Drugs for CD163 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WF10 Approved, Investigational Pharma Target 0
heme Pharma Agonist 0
calcium Nutra 0

(4) Additional Compounds for CD163 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with CD163: view

Transcripts for CD163 Gene

Unigene Clusters for CD163 Gene

CD163 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD163 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for CD163 Gene

GeneLoc Exon Structure for
CD163
ECgene alternative splicing isoforms for
CD163

Expression for CD163 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD163 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD163 Gene

This gene is overexpressed in Whole Blood (x7.6), Adipose - Visceral (Omentum) (x4.5), and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CD163 Gene

This gene is overexpressed in Serum (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD163 Gene



Protein tissue co-expression partners for CD163 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD163 Gene:

CD163

SOURCE GeneReport for Unigene cluster for CD163 Gene:

Hs.504641

mRNA Expression by UniProt/SwissProt for CD163 Gene:

Q86VB7-C163A_HUMAN
Tissue specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
genes like me logo Genes that share expression patterns with CD163: view

Primer Products

Orthologs for CD163 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD163 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD163 34 35
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia CD163 34 35
  • 86.97 (n)
cow
(Bos Taurus)
Mammalia CD163 34 35
  • 85.07 (n)
rat
(Rattus norvegicus)
Mammalia Cd163 34
  • 78.41 (n)
mouse
(Mus musculus)
Mammalia Cd163 34 16 35
  • 78.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 41 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21h14.14 35
  • 36 (a)
ManyToMany
si:dkey-21h14.10 35
  • 35 (a)
ManyToMany
si:dkey-21h14.9 35
  • 35 (a)
ManyToMany
si:dkey-21h14.11 35
  • 34 (a)
ManyToMany
si:dkey-21h14.8 35
  • 33 (a)
ManyToMany
si:ch211-161n3.5 35
  • 32 (a)
ManyToMany
si:ch211-161n3.4 35
  • 28 (a)
ManyToMany
Species where no ortholog for CD163 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD163 Gene

ENSEMBL:
Gene Tree for CD163 (if available)
TreeFam:
Gene Tree for CD163 (if available)

Paralogs for CD163 Gene

Paralogs for CD163 Gene

(6) SIMAP similar genes for CD163 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CD163 Gene

genes like me logo Genes that share paralogs with CD163: view

Variants for CD163 Gene

Sequence variations from dbSNP and Humsavar for CD163 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10128828 -- 7,472,578(+) tcagc(C/T)ccaaa intron-variant
rs10129005 -- 7,472,689(+) ctcct(C/G)tccag intron-variant
rs10690784 -- 7,484,659(+) AAAAA(-/AA)CCTGT intron-variant
rs10734844 -- 7,482,442(+) CAAGC(A/G)ATTCT intron-variant
rs10743939 -- 7,485,424(+) GCAGC(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD163 Gene

Variant ID Type Subtype PubMed ID
dgv1350n100 CNV loss 25217958
esv3303553 CNV mobile element insertion 20981092
esv3399549 CNV insertion 20981092
esv3402244 CNV insertion 20981092
nsv525458 CNV loss 19592680
nsv557269 CNV loss 21841781

Variation tolerance for CD163 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD163 Gene

Human Gene Mutation Database (HGMD)
CD163
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD163

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD163 Gene

Disorders for CD163 Gene

MalaCards: The human disease database

(33) MalaCards diseases for CD163 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rosai-dorfman disease
  • histiocytosis with joint contractures and sensorineural deafness
non-langerhans-cell histiocytosis
  • histiocytosis, non-langerhans-cell
adult xanthogranuloma
necrobiosis lipoidica
histiocytic sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CD163 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD163

Genetic Association Database (GAD)
CD163
Human Genome Epidemiology (HuGE) Navigator
CD163
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD163
genes like me logo Genes that share disorders with CD163: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD163 Gene

Publications for CD163 Gene

  1. Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. (PMID: 10403791) Ritter M. … Schmitz G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Cross-linking of FcgammaR triggers shedding of the hemoglobin- haptoglobin scavenger receptor CD163. (PMID: 15075364) Sulahian T.H. … Guyre P.M. (J. Leukoc. Biol. 2004) 3 4 22 64
  3. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. (PMID: 15478309) Moestrup S.K. … Moller H.J. (Ann. Med. 2004) 3 4 22 64
  4. Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP- 3. (PMID: 12296867) Matsushita N. … Matsuyama T. (Clin. Exp. Immunol. 2002) 3 4 22 64
  5. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. (PMID: 12377940) Hintz K.A. … Guyre P.M. (J. Leukoc. Biol. 2002) 3 4 22 64

Products for CD163 Gene

Sources for CD163 Gene

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