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CD160 Gene

protein-coding   GIFtS: 54
GCID: GC01M145696

CD160 Molecule

(Previous name: CD160 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD160 Molecule1 2     NK282
CD160 Antigen1 2 3     CD160 Transmembrane Isoform2
Natural Killer Cell Receptor BY552 3     CD160-Delta Ig2
BY552 3     Natural Killer Cell Receptor, Immunoglobulin Superfamily Member2
NK12     

External Ids:    HGNC: 170131   Entrez Gene: 111262   Ensembl: ENSG000001172817   OMIM: 6044635   UniProtKB: O959713   
ORGUL members:         

Export aliases for CD160 gene to outside databases

Previous GC identifers: GC01M143371 GC01M143444 GC01M143184 GC01M144407 GC01M119659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD160 Gene:
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression
is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The
cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids
with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a
tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was
highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed
by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing
cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal
intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC
class I molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD160 Gene:
CD160 (CD160 molecule) is a protein-coding gene. Diseases associated with CD160 include neurotrophic keratopathy, and folliculitis. GO annotations related to this gene include MHC class I receptor activity and receptor binding.

UniProtKB/Swiss-Prot: BY55_HUMAN, O95971
Function: Receptor showing broad specificity for both classical and non-classical MHC class I molecules

Gene Wiki entry for CD160 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CD160 gene promoter:
         GR   CREB   FOXF2   deltaCREB   GR-beta   GR-alpha   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD160 promoter sequence
   Search Chromatin IP Primers for CD160

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD160


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.2

CD160 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD160 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M145696:  view genomic region     (about GC identifiers)

Start:
145,695,798 bp from pter      End:
145,715,614 bp from pter
Size:
19,817 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BY55_HUMAN, O95971 (See protein sequence)
Recommended Name: CD160 antigen precursor  
Size: 181 amino acids; 19810 Da
Subunit: Homomultimer; disulfide-linked

Explore the universe of human proteins at neXtProt for CD160: NX_O95971

Explore proteomics data for CD160 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn28, Asn137

  • See CD160 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008984.1  
    ENSEMBL proteins: 
     ENSP00000358294   ENSP00000358296   ENSP00000235933   ENSP00000385199  
    Reactome Protein details: O95971

    CD160 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CD160
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    Sino Biological Cell Lysate for CD160
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    Cloud-Clone Corp. Proteins for CD160

    CD160 Antibody Products:

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    Cloud-Clone Corp. Antibodies for CD160
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    LSBio Antibodies in human, mouse, rat for CD160

    CD160 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CD160
    Cloud-Clone Corp. CLIAs for CD160


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95971

    ProtoNet protein and cluster: O95971

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: BY55_HUMAN, O95971
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD160 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BY55_HUMAN, O95971
    Function: Receptor showing broad specificity for both classical and non-classical MHC class I molecules

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9973372
    GO:0005102receptor binding IDA9973372
    GO:0032393MHC class I receptor activity IDA15494480
         
    CD160 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD160
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD160

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD160
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD160

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD160:
    hsa-mir-335-5p (MIRT018975)

    Block miRNA regulation of human, mouse, rat CD160 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD160:
    hsa-miR-10b* hsa-miR-877* hsa-miR-942 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidCD160 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD160
    Predesigned siRNA for gene silencing in human, mouse, rat CD160

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CD160 (NM_007053)
    Sino Biological Human cDNA Clone for CD160
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD160
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD160

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD160


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BY55_HUMAN, O95971: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0046658anchored component of plasma membrane IDA9973372

    CD160 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD160 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD160
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell



    CD160 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CD160: 
              Cell Surface Markers in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CD160

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD160 (ENSP000002359334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF14ENSP000003479484STRING: ENSP00000347948
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9743336
    GO:0007166cell surface receptor signaling pathway TAS9973372
    GO:0008283cell proliferation TAS9973372
    GO:0050776regulation of immune response TAS--
    GO:0050829defense response to Gram-negative bacterium IEA--

    CD160 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD160 (BY55)

    Selected Novoseek inferred chemical compound relationships for CD160 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    septide 87.4 7 7693605 (2), 1280787 (1), 1717290 (1), 10189055 (1) (see all 6)
    senktide 81.1 5 7827435 (1), 7512696 (1), 7824047 (1), 10189055 (1)
    ly303870 79.2 2 8576917 (1), 9729629 (1)
    physalaemin 69.1 1 7694018 (1)
    sr48968 68.7 1 9831720 (1)
    eledoisin 66.3 1 7824047 (1)
    capsaicin 55.3 9 17978048 (3), 10807884 (2), 1385438 (1), 19326358 (1) (see all 6)
    glutamate 8.96 6 10521569 (2), 18973669 (1), 7911279 (1), 10029365 (1)
    acetylcholine 7.1 3 1385438 (1), 10029365 (1), 7737306 (1)
    histamine 3.05 1 7737306 (1)



    CD160 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD160 gene: 
    NM_007053.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369288(uc001eol.1) ENST00000369290(uc010oyz.1 uc001eom.1)
    ENST00000235933 ENST00000401557
    miRNA
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    Block miRNA regulation of human, mouse, rat CD160 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD160:
    hsa-miR-10b* hsa-miR-877* hsa-miR-942 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidCD160 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD160
    Predesigned siRNA for gene silencing in human, mouse, rat CD160
    Clone
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    OriGene clones in human, mouse for CD160 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD160 (NM_007053)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD160
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD160
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD160
    OriGene qSTAR qPCR primer pairs in human, mouse for CD160
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD160
      QuantiTect SYBR Green Assays in human, mouse, rat CD160
      QuantiFast Probe-based Assays in human, mouse, rat CD160

    18 AceView cDNA sequences:

    NM_007053 CR541888 AK128370 BC014465 BE464987 CR541867 BG743995 BX283351 
    AF060981 BM875543 AA968426 BF433806 CK823969 CD638675 BG744684 BE160189 
    AI917666 BM875294 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD160    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:                    -         
    SP2:        -                     


    ECgene alternative splicing isoforms for CD160

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD160 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGGGG
    CD160 Expression
    About this image


    CD160 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    CD160 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD160 Protein Expression

    UniProtKB/Swiss-Prot: BY55_HUMAN, O95971
    Tissue specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to
    functional NK and T cytotoxic lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including CD160: 
              Cell Surface Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD160

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD160 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1601 , 5 CD160 antigen1, 5 79.33(n)1
    67.04(a)1
      3 (41.99 cM)5
    542151  NM_018767.31  NP_061237.31 
     967987635 


    ENSEMBL Gene Tree for CD160 (if available)
    TreeFam Gene Tree for CD160 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for CD160    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38354841,2
    C--145705569(+) TTATT-/AATAAT 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs339102411,2
    C--145716227(+) TTTCCC/TTTTTT 1 -- us2k10--------
    rs22313731,2,4
    ----see VAR_0277472 mis40--------
    rs26247811,2
    ----152192134(-) ttattA/Tattat 1 -- us2k10--------
    rs1411051231,2
    ----145716227(+) TTTCC-/TTTTTT 1 -- us2k10--------
    rs1127521371,2
    ----145705569(+) TTATTT/AATAAT 1 -- int11Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for CD160 (145695798 - 145715614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CD160 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    nsv818411CNV Loss17921354
    dgv33n27CNV Loss19166990
    nsv469752CNV Loss16826518
    dgv349n71CNV Loss21882294
    esv33868CNV Loss17666407
    nsv428224CNV Gain18775914
    nsv831392CNV Gain17160897
    dgv350n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD160
    DNA2.0 Custom Variant and Variant Library Synthesis for CD160

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604463    OMIM disorders: --

    Selected diseases for CD160 (see all 29):    
    About MalaCards
    neurotrophic keratopathy    folliculitis    keratopathy    paroxysmal nocturnal hemoglobinuria
    allergic contact dermatitis    contact dermatitis    hemoglobinuria    allergic asthma
    cardiovascular disease risk factor    measles    dermatitis    cholestasis
    migraine    asthma    osteoarthritis    gout
    inflammatory bowel disease    astrocytoma    chronic lymphocytic leukemia    hypoxia


    CD160 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CD160 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 30.2 6 19326358 (1), 11275376 (1), 9399010 (1), 17978048 (1) (see all 6)
    airways disease 20.4 1 7573463 (1)
    asthma 11.7 3 12783571 (1), 8627566 (1)
    tumors 4.42 1 11384204 (1)
    necrosis 0 2 11384204 (1), 11260013 (1)

    Genetic Association Database (GAD): CD160
    Human Genome Epidemiology (HuGE) Navigator: CD160 (1 document)

    Export disorders for CD160 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD160 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with CD160)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. (PubMed id 9743336)1, 2, 3, 9 Anumanthan A.... Freeman G.J. (J. Immunol. 1998)
    2. MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (PubMed id 9973372)1, 2, 3 Agrawal S.... Bensussan A. (J. Immunol. 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Possible pathogenic role of the transmembrane isoform of CD160 NK lymphocyte receptor in paroxysmal nocturnal hemoglobinuria. (PubMed id 22172098)1 Giustiniani J....Bensussan A. (Curr. Mol. Med. 2012)
    5. CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction. (PubMed id 22916009)1 Peretz Y....SAckaly R.P. (PLoS Pathog. 2012)
    6. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    7. Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. (PubMed id 21959263)1 Kojima R....Maenaka K. (J. Mol. Biol. 2011)
    8. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. (PubMed id 21482699)1 Chabot S....Le Bouteiller P. (J. Exp. Med. 2011)
    9. Expression profiles of peripheral CD160+ lymphocytes during the course of healthy human pregnancy. (PubMed id 21276121)1 Barakonyi A....Szereday L. (Am. J. Reprod. Immunol. 2011)
    10. Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160. (PubMed id 21191401)1 Ortonne N....Bensussan A. (J. Invest. Dermatol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11126 HGNC: 17013 AceView: CD160 Ensembl:ENSG00000117281 euGenes: HUgn11126
    ECgene: CD160 H-InvDB: CD160

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD160 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD160 gene:
    Search GeneIP for patents involving CD160

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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