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Aliases for CD160 Gene

Aliases for CD160 Gene

  • CD160 Molecule 2 3
  • CD160 Antigen 2 3 4
  • Natural Killer Cell Receptor BY55 3 4
  • BY55 3 4
  • Natural Killer Cell Receptor, Immunoglobulin Superfamily Member 3
  • CD160 Transmembrane Isoform 3
  • CD160-Delta Ig 3
  • NK28 3
  • NK1 3

External Ids for CD160 Gene

Previous GeneCards Identifiers for CD160 Gene

  • GC01M143371
  • GC01M143444
  • GC01M143184
  • GC01M144407
  • GC01M145696
  • GC01M119659

Summaries for CD160 Gene

Entrez Gene Summary for CD160 Gene

  • CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD160 Gene

CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include neurotrophic keratopathy and allergic asthma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor binding and MHC class I receptor activity.

UniProtKB/Swiss-Prot for CD160 Gene

  • Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Gene Wiki entry for CD160 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD160 Gene

Genomics for CD160 Gene

Regulatory Elements for CD160 Gene

Genomic Location for CD160 Gene

Start:
145,719,446 bp from pter
End:
145,739,288 bp from pter
Size:
19,843 bases
Orientation:
Plus strand

Genomic View for CD160 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD160 Gene

Proteins for CD160 Gene

  • Protein details for CD160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95971-BY55_HUMAN
    Recommended name:
    CD160 antigen
    Protein Accession:
    O95971
    Secondary Accessions:

    Protein attributes for CD160 Gene

    Size:
    181 amino acids
    Molecular mass:
    19810 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked

neXtProt entry for CD160 Gene

Proteomics data for CD160 Gene at MOPED

Post-translational modifications for CD160 Gene

  • Glycosylation at Asn28 and Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for CD160 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD160 Gene

Domains for CD160 Gene

Gene Families for CD160 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD160 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD160 Gene

Graphical View of Domain Structure for InterPro Entry

O95971

UniProtKB/Swiss-Prot:

BY55_HUMAN :
  • O95971
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD160: view

Function for CD160 Gene

Molecular function for CD160 Gene

UniProtKB/Swiss-Prot Function: Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Gene Ontology (GO) - Molecular Function for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9973372
GO:0005102 receptor binding IDA 9973372
GO:0005515 protein binding IPI 25416956
GO:0032393 MHC class I receptor activity IDA 15494480
genes like me logo Genes that share ontologies with CD160: view

miRNA for CD160 Gene

miRTarBase miRNAs that target CD160

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD160 Gene

Localization for CD160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD160 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD160 Gene COMPARTMENTS Subcellular localization image for CD160 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0046658 anchored component of plasma membrane IDA 9973372
genes like me logo Genes that share ontologies with CD160: view

Pathways for CD160 Gene

genes like me logo Genes that share pathways with CD160: view

Pathways by source for CD160 Gene

Interacting Proteins for CD160 Gene

Gene Ontology (GO) - Biological Process for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 9743336
GO:0007166 cell surface receptor signaling pathway TAS 9973372
GO:0008283 cell proliferation TAS 9973372
GO:0050776 regulation of immune response TAS --
GO:0050829 defense response to Gram-negative bacterium IEA --
genes like me logo Genes that share ontologies with CD160: view

Compounds for CD160 Gene

(15) Novoseek inferred chemical compound relationships for CD160 Gene

Compound -log(P) Hits PubMed IDs
septide 87.4 7
senktide 81.1 4
ly303870 79.2 2
physalaemin 69.1 1
sr48968 68.7 1
genes like me logo Genes that share compounds with CD160: view

Transcripts for CD160 Gene

mRNA/cDNA for CD160 Gene

Unigene Clusters for CD160 Gene

CD160 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD160 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -

Relevant External Links for CD160 Gene

GeneLoc Exon Structure for
CD160
ECgene alternative splicing isoforms for
CD160

Expression for CD160 Gene

mRNA expression in normal human tissues for CD160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD160 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.4), Brain - Cerebellum (5.3), and Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD160 Gene

SOURCE GeneReport for Unigene cluster for CD160 Gene Hs.740780

mRNA Expression by UniProt/SwissProt for CD160 Gene

O95971-BY55_HUMAN
Tissue specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes
genes like me logo Genes that share expressions with CD160: view

Orthologs for CD160 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD160 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD160 35
  • 99.45 (n)
  • 100 (a)
CD160 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD160 35
  • 82.96 (n)
  • 73.03 (a)
CD160 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd160 35
  • 79.33 (n)
  • 67.04 (a)
Cd160 16
Cd160 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd160 35
  • 78.21 (n)
  • 64.25 (a)
Species with no ortholog for CD160:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD160 Gene

ENSEMBL:
Gene Tree for CD160 (if available)
TreeFam:
Gene Tree for CD160 (if available)

Paralogs for CD160 Gene

No data available for Paralogs for CD160 Gene

Variants for CD160 Gene

Sequence variations from dbSNP and Humsavar for CD160 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1905 -- 145,732,433(-) GCCTC(C/T)AAAAG intron-variant
rs744877 -- 145,720,709(+) CCCCA(A/C)CCTCC intron-variant
rs900343 -- 145,731,146(-) GATAG(A/T)TCAGG intron-variant
rs947535 -- 145,728,795(+) AGGGT(A/C/G/T)AAGAA intron-variant
rs1023945 -- 145,731,972(+) TGTGA(A/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD160 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv529 CNV CNV 17122850
dgv33n27 CNV Loss 19166990
dgv349n71 CNV Loss 21882294
dgv350n71 CNV Gain 21882294
nsv428224 CNV Gain 18775914
dgv351n71 CNV Gain 21882294
nsv872241 CNV Gain+Loss 21882294
nsv831392 CNV Gain 17160897
nsv470735 CNV Gain 18288195
nsv818411 CNV Loss 17921354
esv33868 CNV Loss 17666407
essv3464 CNV CNV 17122850
nsv469752 CNV Loss 16826518
nsv463494 CNV Gain 19166990
dgv352n71 CNV Gain 21882294

Relevant External Links for CD160 Gene

HapMap Linkage Disequilibrium report
CD160

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD160 Gene

Disorders for CD160 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CD160 Gene including...

Search for CD160 Gene in MalaCards »

(5) Novoseek inferred disease relationships for CD160 Gene

Disease -log(P) Hits PubMed IDs
inflammation 30.2 6
airways disease 20.4 1
asthma 11.7 2
tumors 4.42 1
necrosis 0 2

Relevant External Links for CD160

Genetic Association Database (GAD)
CD160
Human Genome Epidemiology (HuGE) Navigator
CD160
genes like me logo Genes that share disorders with CD160: view

No data available for UniProtKB/Swiss-Prot for CD160 Gene

Publications for CD160 Gene

  1. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. (PMID: 9743336) Anumanthan A. … Freeman G.J. (J. Immunol. 1998) 2 3 4 23
  2. MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (PMID: 9973372) Agrawal S. … Bensussan A. (J. Immunol. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. (PMID: 15494480) Barakonyi A. … Le Bouteiller P. (J. Immunol. 2004) 3
  5. Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation. (PMID: 17218942) Abecassis S. … Bensussan A. (J. Invest. Dermatol. 2007) 3

Products for CD160 Gene

Sources for CD160 Gene

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