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Aliases for CD160 Gene

Aliases for CD160 Gene

  • CD160 Molecule 2 3 5
  • Natural Killer Cell Receptor BY55 3 4
  • CD160 Antigen 2 4
  • BY55 3 4
  • Natural Killer Cell Receptor, Immunoglobulin Superfamily Member 3
  • CD160 Transmembrane Isoform 3
  • CD160-Delta Ig 3
  • NK28 3
  • NK1 3

External Ids for CD160 Gene

Previous GeneCards Identifiers for CD160 Gene

  • GC01M143371
  • GC01M143444
  • GC01M143184
  • GC01M144407
  • GC01M145696
  • GC01M119659

Summaries for CD160 Gene

Entrez Gene Summary for CD160 Gene

  • CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD160 Gene

CD160 (CD160 Molecule) is a Protein Coding gene. Diseases associated with CD160 include neurotrophic keratopathy. Among its related pathways are Immune System and Innate Lymphoid Cell Differentiation Pathways. GO annotations related to this gene include receptor binding and MHC class I receptor activity.

UniProtKB/Swiss-Prot for CD160 Gene

  • Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Gene Wiki entry for CD160 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD160 Gene

Genomics for CD160 Gene

Regulatory Elements for CD160 Gene

Promoters for CD160 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD160 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD160 Gene

Chromosome:
1
Start:
145,719,433 bp from pter
End:
145,739,288 bp from pter
Size:
19,856 bases
Orientation:
Plus strand

Genomic View for CD160 Gene

Genes around CD160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD160 Gene

Proteins for CD160 Gene

  • Protein details for CD160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95971-BY55_HUMAN
    Recommended name:
    CD160 antigen
    Protein Accession:
    O95971

    Protein attributes for CD160 Gene

    Size:
    181 amino acids
    Molecular mass:
    19810 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked.

neXtProt entry for CD160 Gene

Proteomics data for CD160 Gene at MOPED

Post-translational modifications for CD160 Gene

  • Glycosylation at Asn 28 and Asn 137
  • Modification sites at PhosphoSitePlus

Other Protein References for CD160 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CD160

No data available for DME Specific Peptides for CD160 Gene

Domains & Families for CD160 Gene

Protein Domains for CD160 Gene

Suggested Antigen Peptide Sequences for CD160 Gene

Graphical View of Domain Structure for InterPro Entry

O95971

UniProtKB/Swiss-Prot:

BY55_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD160: view

Function for CD160 Gene

Molecular function for CD160 Gene

UniProtKB/Swiss-Prot Function:
Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

Gene Ontology (GO) - Molecular Function for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9973372
GO:0005102 receptor binding IDA 9973372
genes like me logo Genes that share ontologies with CD160: view
genes like me logo Genes that share phenotypes with CD160: view

Animal Models for CD160 Gene

MGI Knock Outs for CD160:

Animal Model Products

miRNA for CD160 Gene

miRTarBase miRNAs that target CD160

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD160 Gene

Localization for CD160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD160 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD160 Gene COMPARTMENTS Subcellular localization image for CD160 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD160: view

Pathways & Interactions for CD160 Gene

genes like me logo Genes that share pathways with CD160: view

Interacting Proteins for CD160 Gene

Gene Ontology (GO) - Biological Process for CD160 Gene

None

No data available for SIGNOR curated interactions for CD160 Gene

Drugs & Compounds for CD160 Gene

(11) Drugs for CD160 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CD160 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD160: view

Transcripts for CD160 Gene

Unigene Clusters for CD160 Gene

CD160 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD160 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -

Relevant External Links for CD160 Gene

GeneLoc Exon Structure for
CD160
ECgene alternative splicing isoforms for
CD160

Expression for CD160 Gene

mRNA expression in normal human tissues for CD160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD160 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.3), and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for CD160 Gene

This gene is overexpressed in NK cells (35.2) and Urine (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD160 Gene



SOURCE GeneReport for Unigene cluster for CD160 Gene Hs.740780

mRNA Expression by UniProt/SwissProt for CD160 Gene

O95971-BY55_HUMAN
Tissue specificity: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.
genes like me logo Genes that share expression patterns with CD160: view

Protein tissue co-expression partners for CD160 Gene

Primer Products

In Situ Assay Products

Orthologs for CD160 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD160 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CD160 35
  • 82.96 (n)
  • 73.03 (a)
CD160 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd160 35
  • 79.33 (n)
  • 67.04 (a)
Cd160 16
Cd160 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD160 35
  • 99.45 (n)
  • 100 (a)
CD160 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd160 35
  • 78.21 (n)
  • 64.25 (a)
Species with no ortholog for CD160:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD160 Gene

ENSEMBL:
Gene Tree for CD160 (if available)
TreeFam:
Gene Tree for CD160 (if available)

Paralogs for CD160 Gene

No data available for Paralogs for CD160 Gene

Variants for CD160 Gene

Sequence variations from dbSNP and Humsavar for CD160 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2231373 - 145,730,941(-) GTGAA(A/G)TATCA intron-variant, reference, missense
rs1905 -- 145,732,433(-) GCCTC(C/T)AAAAG intron-variant
rs744877 -- 145,720,709(+) CCCCA(A/C)CCTCC intron-variant
rs900343 -- 145,731,146(+) GATAG(A/T)TCAGG intron-variant
rs947535 -- 145,728,795(+) AGGGT(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD160 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
esv529 CNV CNV 17122850
dgv33n27 CNV Loss 19166990
dgv349n71 CNV Loss 21882294
dgv350n71 CNV Gain 21882294
nsv428224 CNV Gain 18775914
dgv351n71 CNV Gain 21882294
nsv872241 CNV Gain+Loss 21882294
nsv831392 CNV Gain 17160897
nsv470735 CNV Gain 18288195
nsv818411 CNV Loss 17921354
esv33868 CNV Loss 17666407
essv3464 CNV CNV 17122850
nsv469752 CNV Loss 16826518
nsv463494 CNV Gain 19166990
dgv352n71 CNV Gain 21882294

Variation tolerance for CD160 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD160 Gene

HapMap Linkage Disequilibrium report
CD160

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD160 Gene

Disorders for CD160 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD160 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
- elite association - COSMIC cancer census association via MalaCards
Search CD160 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD160

Genetic Association Database (GAD)
CD160
Human Genome Epidemiology (HuGE) Navigator
CD160
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD160
genes like me logo Genes that share disorders with CD160: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD160 Gene

Publications for CD160 Gene

  1. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. (PMID: 9743336) Anumanthan A. … Freeman G.J. (J. Immunol. 1998) 2 3 4 23 67
  2. MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. (PMID: 9973372) Agrawal S. … Bensussan A. (J. Immunol. 1999) 2 3
  3. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. (PMID: 25449536) Suviolahti E. … Toyoda M. (Transpl. Immunol. 2015) 3
  4. Minimal residual disease detection with tumor-specific CD160 correlates with event-free survival in chronic lymphocytic leukemia. (PMID: 25615279) Farren T.W. … Agrawal S.G. (Blood Cancer J 2015) 3
  5. Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4+ T-lymphocyte subset in normal and mycosis fungoides skin. (PMID: 25044837) Sako N. … Schmitt C. (Cytometry A 2014) 3

Products for CD160 Gene

Sources for CD160 Gene

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