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Aliases for CD151 Gene

Aliases for CD151 Gene

  • CD151 Molecule (Raph Blood Group) 2 3 5
  • Platelet-Endothelial Tetraspan Antigen 3 3 4
  • CD151 Antigen (Raph Blood Group) 2 3
  • Membrane Glycoprotein SFA-1 3 4
  • Tetraspanin-24 3 4
  • CD151 Antigen 2 4
  • Tspan-24 3 4
  • TSPAN24 3 4
  • PETA-3 3 4
  • GP27 3 4
  • Platelet-Endothelial Cell Tetraspan Antigen 3 3
  • Platelet Surface Glycoprotein Gp27 3
  • Hemidesmosomal Tetraspanin CD151 3
  • MER2 3
  • RAPH 3
  • SFA1 3

External Ids for CD151 Gene

Previous GeneCards Identifiers for CD151 Gene

  • GC11U990020
  • GC11M000672
  • GC11M000359
  • GC11P000824
  • GC11P000822
  • GC11P000648

Summaries for CD151 Gene

Entrez Gene Summary for CD151 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD151 Gene

CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include nephropathy with pretibial epidermolysis bullosa and deafness and nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome. Among its related pathways are Degradation of the extracellular matrix and Alpha6-Beta4 Integrin Signaling Pathway. GO annotations related to this gene include integrin binding. An important paralog of this gene is ENSG00000250349.

UniProtKB/Swiss-Prot for CD151 Gene

  • Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.

  • (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.

Gene Wiki entry for CD151 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD151 Gene

Genomics for CD151 Gene

Regulatory Elements for CD151 Gene

Promoters for CD151 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD151 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD151 Gene

Chromosome:
11
Start:
832,843 bp from pter
End:
839,831 bp from pter
Size:
6,989 bases
Orientation:
Plus strand

Genomic View for CD151 Gene

Genes around CD151 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD151 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD151 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD151 Gene

Proteins for CD151 Gene

  • Protein details for CD151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48509-CD151_HUMAN
    Recommended name:
    CD151 antigen
    Protein Accession:
    P48509
    Secondary Accessions:
    • A8KAK8
    • E9PI15
    • Q14826
    • Q86U54
    • Q96TE3

    Protein attributes for CD151 Gene

    Size:
    253 amino acids
    Molecular mass:
    28295 Da
    Quaternary structure:
    • Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

neXtProt entry for CD151 Gene

Proteomics data for CD151 Gene at MOPED

Post-translational modifications for CD151 Gene

Antibody Products

No data available for DME Specific Peptides for CD151 Gene

Domains & Families for CD151 Gene

Suggested Antigen Peptide Sequences for CD151 Gene

Graphical View of Domain Structure for InterPro Entry

P48509

UniProtKB/Swiss-Prot:

CD151_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD151: view

Function for CD151 Gene

Molecular function for CD151 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD151,expressed in platelets
UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
UniProtKB/Swiss-Prot Induction:
By HTLV-1.
genes like me logo Genes that share phenotypes with CD151: view

Human Phenotype Ontology for CD151 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD151 Gene

MGI Knock Outs for CD151:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD151

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CD151 Gene

Localization for CD151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD151 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD151 Gene COMPARTMENTS Subcellular localization image for CD151 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8627808
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD151: view

Pathways & Interactions for CD151 Gene

genes like me logo Genes that share pathways with CD151: view

Gene Ontology (GO) - Biological Process for CD151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization TAS --
GO:0031581 hemidesmosome assembly TAS --
GO:0034329 cell junction assembly TAS --
genes like me logo Genes that share ontologies with CD151: view

No data available for SIGNOR curated interactions for CD151 Gene

Drugs & Compounds for CD151 Gene

(1) Drugs for CD151 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CD151 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD151: view

Transcripts for CD151 Gene

Unigene Clusters for CD151 Gene

CD151 molecule (Raph blood group):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD151 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - -
SP19:
SP20: - - - - - - - -
SP21: - - - - -
SP22: -

ExUns: 12a · 12b · 12c · 12d · 12e ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CD151 Gene

GeneLoc Exon Structure for
CD151
ECgene alternative splicing isoforms for
CD151

Expression for CD151 Gene

mRNA expression in normal human tissues for CD151 Gene

mRNA differential expression in normal tissues according to GTEx for CD151 Gene

This gene is overexpressed in Artery - Aorta (x4.7).

Protein differential expression in normal tissues from HIPED for CD151 Gene

This gene is overexpressed in Nasal epithelium (13.8) and Gallbladder (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CD151 Gene



SOURCE GeneReport for Unigene cluster for CD151 Gene Hs.654379

mRNA Expression by UniProt/SwissProt for CD151 Gene

P48509-CD151_HUMAN
Tissue specificity: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.
genes like me logo Genes that share expression patterns with CD151: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CD151 Gene

Orthologs for CD151 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD151 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD151 35
  • 87.48 (n)
  • 90.91 (a)
CD151 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD151 35
  • 91.01 (n)
  • 95.24 (a)
CD151 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd151 35
  • 87.09 (n)
  • 93.68 (a)
Cd151 16
Cd151 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD151 35
  • 99.47 (n)
  • 100 (a)
CD151 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911730 35
  • 87.09 (n)
  • 92.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CD151 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD151 35
  • 75 (n)
  • 78.97 (a)
CD151 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD151 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd151 35
  • 72.2 (n)
  • 77.08 (a)
zebrafish
(Danio rerio)
Actinopterygii cd151l 35
  • 68.77 (n)
  • 71.54 (a)
Dr.7676 35
cd151 36
  • 65 (a)
OneToMany
cd151l 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8672 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011342 35
  • 49.33 (n)
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp74F 35
  • 46.93 (n)
  • 31.58 (a)
Tsp74F 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8828 36
  • 41 (a)
OneToMany
Species with no ortholog for CD151:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD151 Gene

ENSEMBL:
Gene Tree for CD151 (if available)
TreeFam:
Gene Tree for CD151 (if available)

Paralogs for CD151 Gene

genes like me logo Genes that share paralogs with CD151: view

Variants for CD151 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD151 Gene

P48509-CD151_HUMAN
CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

Sequence variations from dbSNP and Humsavar for CD151 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_012490 -
VAR_012491 -
VAR_021153 -
rs34215390 - 837,257(+) GAACA(C/T)GGAGC reference, missense
rs8672 -- 838,634(+) CAGCC(C/G)TCGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD151 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
dgv949n71 CNV Loss 21882294
dgv950n71 CNV Gain 21882294
dgv951n71 CNV Loss 21882294
nsv896608 CNV Loss 21882294
dgv952n71 CNV Loss 21882294
dgv953n71 CNV Gain 21882294
dgv954n71 CNV Gain 21882294
nsv896619 CNV Gain 21882294
nsv896620 CNV Gain+Loss 21882294
dgv955n71 CNV Loss 21882294
nsv896630 CNV Loss 21882294
esv1212776 CNV Insertion 17803354

Variation tolerance for CD151 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD151 Gene

HapMap Linkage Disequilibrium report
CD151
Human Gene Mutation Database (HGMD)
CD151
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for CD151 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CD151 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephropathy with pretibial epidermolysis bullosa and deafness
  • npebd
nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome
  • nephrotic syndrome-hearing loss-pretibial epidermolysis bullosa syndrome
skin squamous cell carcinoma
  • epidermoid skin carcinoma
thalassemia minor
  • beta-thalassemia minor
reticulate acropigmentation of kitamura
  • rapk
- elite association - COSMIC cancer census association via MalaCards
Search CD151 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD151_HUMAN
  • Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. {ECO:0000269 PubMed:15265795}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD151

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD151
genes like me logo Genes that share disorders with CD151: view

No data available for Genatlas for CD151 Gene

Publications for CD151 Gene

  1. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. (PMID: 7632941) Fitter S. … Ashman L.K. (Blood 1995) 3 4 23 67
  2. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. (PMID: 19065669) Ke A.W. … Fan J. (Hepatology 2009) 3 23
  3. CD151 regulates HGF-stimulated morphogenesis of human breast cancer cells. (PMID: 19159612) Klosek S.K. … Hamakawa H. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. (PMID: 19330835) Hirano C. … Takagi R. (Int. J. Cancer 2009) 3 23
  5. Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts. (PMID: 19509057) Johnson J.L. … Stipp C.S. (J. Cell. Sci. 2009) 3 23

Products for CD151 Gene

Sources for CD151 Gene

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