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Aliases for CD151 Gene

Aliases for CD151 Gene

  • CD151 Molecule (Raph Blood Group) 2 3
  • CD151 Antigen 2 3 4
  • Platelet-Endothelial Tetraspan Antigen 3 3 4
  • CD151 Antigen (Raph Blood Group) 2 3
  • Membrane Glycoprotein SFA-1 3 4
  • Tetraspanin-24 3 4
  • Tspan-24 3 4
  • TSPAN24 3 4
  • PETA-3 3 4
  • MER2 3 6
  • SFA1 3 6
  • GP27 3 4
  • Platelet-Endothelial Cell Tetraspan Antigen 3 3
  • Platelet Surface Glycoprotein Gp27 3
  • Hemidesmosomal Tetraspanin CD151 3
  • PETA3 6
  • RAPH 3

External Ids for CD151 Gene

Summaries for CD151 Gene

Entrez Gene Summary for CD151 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD151 Gene

CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include nephropathy with pretibial epidermolysis bullosa and deafness and nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome. Among its related pathways are Degradation of the extracellular matrix and Cell junction organization. An important paralog of this gene is TSPAN7.

UniProtKB/Swiss-Prot for CD151 Gene

  • Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.

Gene Wiki entry for CD151 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD151 Gene

Genomics for CD151 Gene

Genomic Location for CD151 Gene

Start:
832,843 bp from pter
End:
839,831 bp from pter
Size:
6,989 bases
Orientation:
Plus strand

Genomic View for CD151 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD151 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD151 Gene

Regulatory Elements for CD151 Gene

Proteins for CD151 Gene

  • Protein details for CD151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48509-CD151_HUMAN
    Recommended name:
    CD151 antigen
    Protein Accession:
    P48509
    Secondary Accessions:
    • A8KAK8
    • E9PI15
    • Q14826
    • Q86U54
    • Q96TE3

    Protein attributes for CD151 Gene

    Size:
    253 amino acids
    Molecular mass:
    28295 Da
    Quaternary structure:
    • Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181

neXtProt entry for CD151 Gene

Proteomics data for CD151 Gene at MOPED

Post-translational modifications for CD151 Gene

No data available for DME Specific Peptides for CD151 Gene

Domains for CD151 Gene

Gene Families for CD151 Gene

HGNC:

UniProtKB/Swiss-Prot:

CD151_HUMAN
Family:
  • Belongs to the tetraspanin (TM4SF) family.:
    • P48509
genes like me logo Genes that share domains with CD151: view

Function for CD151 Gene

Molecular function for CD151 Gene

GENATLAS Biochemistry: cell differentiation antigen CD151,expressed in platelets
UniProtKB/Swiss-Prot Function: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
UniProtKB/Swiss-Prot Induction: By HTLV-1

Gene Ontology (GO) - Molecular Function for CD151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 24220332
GO:0005515 protein binding IPI 14676841
genes like me logo Genes that share ontologies with CD151: view
genes like me logo Genes that share phenotypes with CD151: view

Animal Models for CD151 Gene

MGI Knock Outs for CD151:

miRNA for CD151 Gene

miRTarBase miRNAs that target CD151

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD151 Gene

Localization for CD151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD151 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD151 Gene COMPARTMENTS Subcellular localization image for CD151 gene
Compartment Confidence
cytosol 4
plasma membrane 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CD151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IDA 23302890
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8627808
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CD151: view

Pathways for CD151 Gene

genes like me logo Genes that share pathways with CD151: view

Gene Ontology (GO) - Biological Process for CD151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 9602068
GO:0016477 cell migration IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0031581 hemidesmosome assembly TAS --
GO:0034329 cell junction assembly TAS --
genes like me logo Genes that share ontologies with CD151: view

Compounds for CD151 Gene

(3) Novoseek inferred chemical compound relationships for CD151 Gene

Compound -log(P) Hits PubMed IDs
matrigel 32.3 1
cysteine 0.304 2
fibrinogen 0 1
genes like me logo Genes that share compounds with CD151: view

Transcripts for CD151 Gene

Unigene Clusters for CD151 Gene

CD151 molecule (Raph blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD151 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - -
SP19:
SP20: - - - - - - - -
SP21: - - - - -
SP22: -

ExUns: 12a · 12b · 12c · 12d · 12e ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CD151 Gene

GeneLoc Exon Structure for
CD151
ECgene alternative splicing isoforms for
CD151

Expression for CD151 Gene

mRNA expression in normal human tissues for CD151 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD151 Gene

This gene is overexpressed in Artery - Aorta (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD151 Gene

SOURCE GeneReport for Unigene cluster for CD151 Gene Hs.654379

mRNA Expression by UniProt/SwissProt for CD151 Gene

P48509-CD151_HUMAN
Tissue specificity: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.
genes like me logo Genes that share expressions with CD151: view

Orthologs for CD151 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD151 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD151 36
  • 99.47 (n)
  • 100 (a)
CD151 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD151 36
  • 87.48 (n)
  • 90.91 (a)
CD151 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD151 36
  • 91.01 (n)
  • 95.24 (a)
CD151 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd151 36
  • 87.09 (n)
  • 93.68 (a)
Cd151 16
Cd151 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CD151 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911730 36
  • 87.09 (n)
  • 92.89 (a)
chicken
(Gallus gallus)
Aves CD151 36
  • 75 (n)
  • 78.97 (a)
CD151 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD151 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd151 36
  • 72.2 (n)
  • 77.08 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8672 36
zebrafish
(Danio rerio)
Actinopterygii cd151 37
  • 65 (a)
OneToMany
cd151l 36
  • 68.77 (n)
  • 71.54 (a)
cd151l 37
  • 71 (a)
OneToMany
Dr.7676 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011342 36
  • 49.33 (n)
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp74F 36
  • 46.93 (n)
  • 31.58 (a)
Tsp74F 37
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8828 37
  • 41 (a)
OneToMany
Species with no ortholog for CD151:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD151 Gene

ENSEMBL:
Gene Tree for CD151 (if available)
TreeFam:
Gene Tree for CD151 (if available)

Paralogs for CD151 Gene

genes like me logo Genes that share paralogs with CD151: view

Variants for CD151 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD151 Gene

P48509-CD151_HUMAN
CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative

Sequence variations from dbSNP and Humsavar for CD151 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6762 -- 838,722(+) CCTGT(C/T)CATGT utr-variant-3-prime
rs8672 -- 838,634(+) CAGCC(C/G)TCGTC utr-variant-3-prime
rs1130663 -- 837,582(+) TGTGG(A/G)CAGCG synonymous-codon, reference
rs1130678 -- 838,419(+) TCCCC(A/G/T)GACAC utr-variant-3-prime
rs1130680 -- 838,424(+) AGACA(C/T)ACTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD151 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
dgv949n71 CNV Loss 21882294
dgv950n71 CNV Gain 21882294
dgv951n71 CNV Loss 21882294
nsv896608 CNV Loss 21882294
dgv952n71 CNV Loss 21882294
dgv953n71 CNV Gain 21882294
dgv954n71 CNV Gain 21882294
nsv896619 CNV Gain 21882294
nsv896620 CNV Gain+Loss 21882294
dgv955n71 CNV Loss 21882294
nsv896630 CNV Loss 21882294
esv1212776 CNV Insertion 17803354

Relevant External Links for CD151 Gene

HapMap Linkage Disequilibrium report
CD151
Human Gene Mutation Database (HGMD)
CD151
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for CD151 Gene

(2) OMIM Diseases for CD151 Gene (602243)

UniProtKB/Swiss-Prot

CD151_HUMAN
  • Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. {ECO:0000269 PubMed:15265795}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(10) Novoseek inferred disease relationships for CD151 Gene

Disease -log(P) Hits PubMed IDs
metastasis 35.8 7
tumors 18.2 17
cancer 3.66 8
carcinoma 0.231 3
leukemia 0 1
genes like me logo Genes that share disorders with CD151: view

Publications for CD151 Gene

  1. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. (PMID: 7632941) Fitter S. … Ashman L.K. (Blood 1995) 3 4 23
  2. Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene. (PMID: 11181065) Whittock N.V. … McLean W.H.I. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. (PMID: 11907260) Yang X. … Hemler M.E. (Mol. Biol. Cell 2002) 3 4 23
  4. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. (PMID: 12175627) Mazzocca A. … Pinzani M. (J. Hepatol. 2002) 3 23
  5. Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151. (PMID: 15677332) Nishiuchi R. … Sekiguchi K. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23

Products for CD151 Gene

Sources for CD151 Gene

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