Aliases for CD14 Gene
External Ids for CD14 Gene
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
GeneCards Summary for CD14 Gene
CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include burning mouth syndrome and monocytic leukemia. Among its related pathways are MAPK signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.
UniProtKB/Swiss-Prot for CD14 Gene
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.