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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD14 Gene

protein-coding   GIFtS: 67
GCID: GC05M139991

CD14 Molecule

(Previous name: CD14 antigen)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD14 Molecule1 2
CD14 Antigen1 3
Myeloid Cell-Specific Leucine-Rich Glycoprotein2 3
Monocyte Differentiation Antigen CD142

External Ids:    HGNC: 16281   Entrez Gene: 9292   Ensembl: ENSG000001704587   OMIM: 1581205   UniProtKB: P085713   

Export aliases for CD14 gene to outside databases

Previous GC identifers: GC05M139827 GC05M140594 GC05M139994 GC05M140039 GC05M135156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD14 Gene:
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages.
It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide.
Alternative splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Mar
2010)

GeneCards Summary for CD14 Gene: 
CD14 (CD14 molecule) is a protein-coding gene. Diseases associated with CD14 include light chain deposition disease, and burning mouth syndrome, and among its related super-pathways are TLR-TRIF Pathway and Immune response TLR signaling pathways. GO annotations related to this gene include lipoteichoic acid binding and lipopolysaccharide binding.

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex,
thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and
TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell
surface molecules, including adhesion molecules

Gene Wiki entry for CD14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD14 gene promoter:
         CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3

CD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139991:  view genomic region     (about GC identifiers)

Start:
140,011,313 bp from pter      End:
140,013,286 bp from pter
Size:
1,974 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571 (See protein sequence)
Recommended Name: Monocyte differentiation antigen CD14 precursor  
Size: 375 amino acids; 40076 Da
Subunit: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2
and TLR4
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
1 PDB 3D structure from and Proteopedia for CD14:
4GLP (3D)    
Secondary accessions: Q53XT5 Q96FR6 Q96L99 Q9UNS3

Explore the universe of human proteins at neXtProt for CD14: NX_P08571

Explore proteomics data for CD14 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08571

  • CD14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD14 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000582.1  NP_001035110.1  NP_001167575.1  NP_001167576.1  

    ENSEMBL proteins: 
     ENSP00000304236   ENSP00000426543   ENSP00000430884   ENSP00000425447   ENSP00000385519  
    Reactome Protein details: P08571
    Human Recombinant Protein Products for CD14: 
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    Enzo Life Sciences proteins for CD14
    OriGene Purified Proteins for CD14
    OriGene Protein Over-expression Lysate for CD14
    OriGene MassSpec for CD14 
    OriGene Custom Protein Services for CD14
    GenScript Custom Purified and Recombinant Proteins Services for CD14
    Novus Biologicals CD14 Proteins
    Novus Biologicals CD14 Lysates
    Sino Biological Recombinant Protein for CD14
    Sino Biological Cell Lysate for CD14 
    ProSpec Recombinant Protein for CD14
    Cloud-Clone Corp. Proteins for CD14 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0010008endosome membrane TAS--

    CD14 for ontologies           About GeneDecksing



    CD14 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CD14 

    Assay Products for CD14: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CD14         (see all)
    GenScript Custom Assay Services for CD14
    Enzo Life Sciences assays for CD14
    Cloud-Clone Corp. ELISAs for CD14 
    Cloud-Clone Corp. CLIAs for CD14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR016337 Monocyte_diff_Ag_CD14

    Graphical View of Domain Structure for InterPro Entry P08571

    ProtoNet protein and cluster: P08571

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
    Similarity: Contains 11 LRR (leucine-rich) repeats


    CD14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD14_HUMAN, P08571
    Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex,
    thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and
    TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell
    surface molecules, including adhesion molecules

         Genatlas biochemistry entry for CD14:
    cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of
    apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a
    liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies
    My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IDA12594207
    GO:0001847opsonin receptor activity TAS2402637
    GO:0005515protein binding IPI--
    GO:0016019peptidoglycan receptor activity TAS8798531
    GO:0070891lipoteichoic acid binding IDA12594207
         
    CD14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD14:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd14):
     adipose tissue  growth/size  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system  skeleton 

    CD14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD14: Cd14tm1Smg Cd14tm1Frm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD14 

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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CD14 (NM_000591)
    Sino Biological Human cDNA Clone for CD14
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD14 About   (see all 31)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Toll Comparative Pathway
    Toll Comparative Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    5Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for CD14
        Transcription NF-kB signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response MIF in innate immunity response
    Immune response IL-10 signaling pathway
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    2 R&D Systems Pathways for CD14
        A-beta Uptake & Degradation
    Toll-Like receptor Signaling Pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD14 (see all 8)
        iNOS Signaling
    LPS Stimulated MAPK Signaling
    MIF Regulation of Innate Immune Cells
    Toll-Like Receptors Pathway
    IL-10 Pathway

    5/9 GeneGo (Thomson Reuters) Pathways for CD14 (see all 9)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    4 BioSystems Pathways for CD14
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton
    Toll-like receptor signaling pathway
    Pathogenic Escherichia coli infection


    5/17        Reactome Pathways for CD14 (see all 17)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    Transfer of LPS from LBP carrier to CD14


    5/13         Kegg Pathways  (Kegg details for CD14) (see all 13):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Phagosome
    Toll-like receptor signaling pathway
    Hematopoietic cell lineage


    CD14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for CD14 (P085712, 3 ENSP000003042364) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIP2AQ146892, 3, ENSP000003920664MINT-7991045 I2D: score=1 STRING: ENSP00000392066
    FSTL1Q128412, 3, ENSP000002956334MINT-7990653 MINT-7990768 MINT-8302262 I2D: score=1 STRING: ENSP00000295633
    LBPP184283, ENSP000002174074I2D: score=3 STRING: ENSP00000217407
    CD55P081743, ENSP000003163334I2D: score=2 STRING: ENSP00000316333
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002237response to molecule of bacterial origin ----
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006909phagocytosis TAS9548256

    CD14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD14

    10/99 Novoseek inferred chemical compound relationships for CD14 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 80.3 199 17949800 (6), 7694296 (5), 16614348 (3), 8798531 (3) (see all 99)
    lipoteichoic acid 75.4 43 18458151 (5), 12594207 (4), 12011760 (3), 11559761 (3) (see all 15)
    peptidoglycan 65.6 46 8798531 (4), 16239565 (3), 9535844 (2), 15358661 (2) (see all 20)
    alpha-naphthyl butyrate 59.6 5 9737693 (1), 8639885 (1), 2070083 (1)
    1,25 dihydroxy vitamin d3 50.5 7 18559006 (3), 15730927 (1), 9168815 (1)
    nitroblue tetrazolium 50 6 11911463 (1), 15467202 (1), 9337080 (1), 12214860 (1) (see all 6)
    polymyxin b 49.1 7 17854214 (2), 10966488 (1)
    calcitriol 45.3 32 18495781 (4), 9773783 (4), 17327484 (3), 7522257 (2) (see all 17)
    n-acetylmuramyl-l-alanyl-d-isoglutamine 44.9 1 11705912 (1)
    fmlp 44.7 6 8933153 (1), 1370419 (1), 12747235 (1), 12094616 (1)

    Search CenterWatch for drugs/clinical trials and news about CD14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD14 gene (4 alternative transcripts): 
    NM_000591.3  NM_001040021.2  NM_001174104.1  NM_001174105.1  

    Unigene Cluster for CD14:

    CD14 molecule
    Hs.163867  [show with all ESTs]
    Unigene Representative Sequence: NM_001174104
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302014(uc003lgi.2) ENST00000498971 ENST00000519715 ENST00000512545
    ENST00000401743(uc003lgj.2 uc021yej.1 uc021yek.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD14
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD14

    Additional mRNA sequence: 

    AB446505.1 AF097942.1 AK313277.1 AY044269.1 BC010507.2 BT007331.1 M86511.1 X13334.1 

    11 DOTS entries:

    DT.418882  DT.100880397  DT.95140005  DT.95140028  DT.100880401  DT.100880417  DT.120890632  DT.95140026 
    DT.100693968  DT.100880399  DT.100880396 

    24/503 AceView cDNA sequences (see all 503):

    BM998765 CR590355 CR610684 CR620234 CR601474 BG058698 AL553094 AY044269 
    CD366124 BM547514 CR614015 CA306817 BF344679 AA322502 AL549182 AL551553 
    CN480086 BX459244 BX385964 BG490887 CD672945 AI090064 BX416831 CA418638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD14 expression in normal human tissues (normalized intensities)      CD14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCCAGCG
    CD14 Expression
    About this image


    CD14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Mesenchymal Stem Cells
             Placenta-derived adherent stromal cell (PLX)
     
     Bone (Muscoskeletal System)    fully expand to see all 17 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived mesenchymal stromal cells
     
     Blood (Hematopoietic System)    fully expand to see all 14 entries
             Monocytes Peripheral Blood
             Umbilical cord blood-derived mesenchymal stem/progenitor cells
             Enriched erythrocyte-like cells ( Generation and expansion of erythroid cells )
             Fetal Liver CD36+ Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 7 entries
             Sinusoidal Endothelial Cells Sinusoids
             Peripheral blood-derived endothelial progenitor cells
             Purified endothelial-like cells ( Generation of endothelial cells from human embryonic...
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 7 entries
             Hofbauer Cells Chorionic Villus
             Placenta-derived adherent stromal cell (PLX)

    See CD14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD14

    SOURCE GeneReport for Unigene cluster: Hs.163867

    UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
    Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also
    expressed by most tissue macrophages

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD14 (see all 9): 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD14 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd141 , 5 CD14 antigen1, 5 73.24(n)1
    67.12(a)1
      18 (19.46 cM)5
    124751  NM_009841.31  NP_033971.11 
     367250675 
    chicken
    (Gallus gallus)
    Aves CD146
    CD14 molecule precursor
    24(a)
    1 ↔ 1
    13(402430-403827)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    22(a)
    21(a)
    many → 1
    many → 1
    4(77746112-77747416)
    4(77840668-77842038)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG552546.12   -- 71.21(n)    BG552546.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.137852 Oncorhynchus mykiss transcribed sequence with weak more 70.82(n)    BX876915.1 


    ENSEMBL Gene Tree for CD14 (if available)
    TreeFam Gene Tree for CD14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/136 SNPs in CD14 are shown (see all 136)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924962791,2
    --140287578(+) GTGTGA/TGAGAG 4 -- ds50010--------
    rs1399624741,2
    --140287626(+) TTTATC/TACCTT 4 -- ds50010--------
    rs25632981,2
    C,F,O,A,H--140287958(+) ACGGAC/ACCGTT 4 -- ut3125Minor allele frequency- A:0.19EA NA EU NS WA CSA 2648
    rs37761381,2
    C,F,H--140287964(-) TTAAAC/GAACGG 4 -- ut317Minor allele frequency- G:0.00NA EU NS EA 506
    rs57444561,2
    C,F,H--140287992(-) AACCCT/ATTGCC 4 -- ut319Minor allele frequency- A:0.03NA EU MN NS EA WA 790
    rs1444379531,2
    --140288006(+) TTGGTC/TGAAAA 4 -- ut310--------
    rs2012593241,2
    F--140288020(+) CTCAAC/TGTCCT 4 -- ut311Minor allele frequency- T:0.00EU 577
    rs49141,2
    C,F,A,H--140288111(+) TGGAGC/GAGCAC 8 L syn1 ese321Minor allele frequency- G:0.11MN NA EU NS EA CSA WA 6840
    rs3750454201,2
    C--140288137(+) CCCCAC/TCGACA 8 M V mis10--------
    rs115561791,2,4
    C,F,H--140288191(+) GCCCTC/TGTGGG 8 K E mis1 ese36Minor allele frequency- T:0.00NS EA NA 4930

    HapMap Linkage Disequilibrium report for CD14 (140011313 - 140013286 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD14: --

    Human Gene Mutation Database (HGMD): CD14
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD14
    DNA2.0 Custom Variant and Variant Library Synthesis for CD14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 158120    OMIM disorders: --

    20/171 diseases for CD14 (see all 171):    About MalaCards
    light chain deposition disease    burning mouth syndrome    monocytic leukemia    acute monocytic leukemia
    extrinsic allergic alveolitis    al amyloidosis    viral meningitis    secondary amyloidosis
    cardiogenic shock    peritonitis    preterm premature rupture of the membranes    bone fracture
    pouchitis    brucellosis    hemoglobinuria    otitis media
    carotid artery disease    peptic ulcer    food allergy    atopy


    CD14 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for CD14 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 69.6 86 8975896 (2), 16148556 (2), 11477201 (2), 7685250 (2) (see all 75)
    gram-negative bacterial infections 64.7 1 19109192 (1)
    sepsis 62.6 70 19371402 (5), 14720421 (4), 9488406 (4), 18991094 (4) (see all 33)
    monocytic leukemia 62.2 6 7510927 (1), 10547074 (1), 10488701 (1), 1493908 (1) (see all 5)
    inflammation 57.2 40 11590384 (4), 19390489 (2), 16142747 (2), 12928151 (1) (see all 29)
    shock septic 57 16 11219189 (3), 9553985 (2), 8833900 (2), 7688151 (2) (see all 11)
    atopy 56.1 31 17949800 (2), 18312481 (2), 17877764 (2), 16306212 (2) (see all 21)
    paroxysmal hemoglobinuria nocturnal 54.6 4 1376258 (1), 9488406 (1), 7537790 (1)
    acute monocytic leukemia 50.9 2 7510927 (1)
    asthma allergic 46.1 17 11590384 (3), 19148143 (2), 15378299 (2), 9551731 (2) (see all 9)

    Genetic Association Database (GAD): CD14
    Human Genome Epidemiology (HuGE) Navigator: CD14 (346 documents)

    Export disorders for CD14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD14 gene, integrated from 9 sources (see all 1369):
    (articles sorted by number of sources associating them with CD14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. (PubMed id 2472171)1, 2, 3 Setoguchi M....Yamamoto S. (1989)
    2. Monocyte antigen CD14 is a phospholipid anchored membrane protein. (PubMed id 2462937)1, 2, 3 Simmons D.L.... Seed B. (1989)
    3. CD14 expression on monocytes and soluble CD14 plasma levels in correlation to the promotor polymorphism of the endotoxin receptor CD14 gene in patients with inactive Crohn's disease. (PubMed id 15966209)1, 4, 9 Griga T....May B. (2005)
    4. CD14 polymorphisms and serum CD14 levels through chil dhood: a role for gene methylation? (PubMed id 20398919)1, 4, 9 Munthe-Kaas M.C....Lyle R. (2010)
    5. Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (PubMed id 17949800)1, 4, 9 Levan T.D....Martinez F.D. (2008)
    6. [CD14 genomic polymorphism influences CD14 expression in whole blood culture] (PubMed id 16194368)1, 4, 9 Lin J....Sheng Z.Y. (2005)
    7. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. (PubMed id 15655821)1, 4, 9 Gazouli M....Gorgoulis V.G. (2005)
    8. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PubMed id 18951711)1, 4, 9 Lin J....Sheng Z.Y. (2008)
    9. [The influence of CD14 genomic polymorphism on CD14 gene expression as well as protein release and its clinical significance in patients with extensive burns] (PubMed id 17067484)1, 4, 9 Lin J....Sheng Z.Y. (2006)
    10. Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection. (PubMed id 16273620)1, 4, 9 Meiler C....Hellerbrand C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 929 HGNC: 1628 AceView: CD14 Ensembl:ENSG00000170458 euGenes: HUgn929
    ECgene: CD14 Kegg: 929 H-InvDB: CD14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD14

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD14 gene:
    Search GeneIP for patents involving CD14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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