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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD14 Gene

protein-coding GIFtS: 67
GCID: GC05M139991

CD14 molecule

(Previous name: CD14 antigen )

Explore 177 diseases affiliated with
CD14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD14 Molecule¹ ²
CD14 Antigen¹ ³
Myeloid Cell-Specific Leucine-Rich Glycoprotein² ³
Monocyte Differentiation Antigen CD14²

External Ids:	HGNC: 1628¹	Entrez Gene: 929²	Ensembl: ENSG00000170458⁷	OMIM: 158120⁵	UniProtKB: P08571³

Export aliases for CD14 gene to outside databases

Previous GC identifers: GC05M139827 GC05M140594 GC05M139994 GC05M140039 GC05M135156

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD14:

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It

cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative

splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571

Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby

mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading

to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules,

including adhesion molecules

Gene Wiki entry for CD14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD14 gene promoter:
CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD14 promoter sequence

Search SABiosciences Chromatin IP Primers for CD14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3

CD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD14 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M139991: view genomic region (about GC identifiers)

Start:	140,011,313 bp from pter	End:	140,013,286 bp from pter
Size:	1,974 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571 (See protein sequence)

Recommended Name: Monocyte differentiation antigen CD14 precursor

Size: 375 amino acids; 40076 Da

Subunit: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and

TLR4

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor

1 PDB 3D structure from and Proteopedia for CD14:

4GLP (3D)

Secondary accessions: Q53XT5 Q96FR6 Q96L99 Q9UNS3

Explore the universe of human proteins at neXtProt for CD14: NX_P08571

Post-translational modifications:

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08571

CD14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000582.1 NP_001035110.1 NP_001167575.1 NP_001167576.1

ENSEMBL proteins:

ENSP00000304236 ENSP00000426543 ENSP00000430884 ENSP00000425447 ENSP00000385519

Reactome Protein details: P08571
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for CD14
	Novus Biologicals CD14 Proteins Novus Biologicals CD14 Lysates
	Sino Biological Recombinant Protein for CD14
	ProSpec Recombinant Protein for CD14
	Uscn Proteins for CD14

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	IEA	--
GO:0010008	endosome membrane	TAS	--

CD14 for ontologies About GeneDecksing

CD14 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD14
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	ThermoFisher Antibody for CD14

Assay Products for CD14:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CD14 (see all)
	GenScript Custom Assay Services for CD14
	Enzo Life Sciences assays for CD14
	Uscn ELISAs and CLIAs for CD14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD14 for domains About GeneDecksing

2 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR016337 Monocyte_diff_Ag_CD14

Graphical View of Domain Structure for InterPro Entry P08571

ProtoNet protein and cluster: P08571

1 Blocks protein family: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571

Similarity: Contains 11 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571

Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby

mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading

to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules,

including adhesion molecules

Genatlas biochemistry entry for CD14:

cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic

cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide

signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor

for myocardial infarction

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD14
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		SwitchGear 3'UTR luciferase reporter plasmid: CD14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD14 (see all 7) OriGene shRNA RFP: CD14 OriGene siRNA: CD14
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD14 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD14 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD14
		Search LifeMap BioReagents cell lines for CD14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001530	lipopolysaccharide binding	IDA	12594207
GO:0001847	opsonin receptor activity	TAS	2402637
GO:0005515	protein binding	--	--
GO:0016019	peptidoglycan receptor activity	TAS	8798531
GO:0070891	lipoteichoic acid binding	IDA	12594207

CD14 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD14:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for CD14: Cd14^tm1Smg Cd14^tm1Frm
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd14):

adipose tissue	growth/size	homeostasis/metabolism	immune system	mortality/aging
respiratory system	skeleton

CD14 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/10 pathways (see all 10)
Toll Like Receptor TLR1:TLR2 Cascade	0.78	MyD88-independent cascade	0.72
Toll Like Receptor TLR6:TLR2 Cascade	0.78	Toll Like Receptor 3 (TLR3) Cascade	0.72
Toll Like Receptor 2 (TLR2) Cascade	0.78	Activated TLR4 signalling	0.63
MyD88:Mal cascade initiated on plasma membrane	0.78	Toll Like Receptor 4 (TLR4) Cascade	0.61

Auto ubiquitination of TRAF6 bound to the activated TLR complex

Auto ubiquitination of TRAF6 bound to the activated TLR complex	1.00	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.62
Auto-ubiquitination of TRAF3	0.83	IKK complex recruitment mediated by RIP1	0.50
TRAF6 mediated induction of TAK1 complex	0.73	TRIF-mediated programmed cell death	0.40

Toll Comparative Pathway

	Toll Comparative Pathway	1.00			Immune response MIF in innate immunity response	0.46
	Immune response_MIF in innate immunity response	0.46			iNOS Signaling	0.34

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	1.00			Toll-Like receptor Signaling Pathways	0.51
	Toll-like receptor signaling pathway	0.97

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway

1.00

Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for CD14

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response MIF in innate immunity response
	Immune response IL-10 signaling pathway
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

2 R&D Systems Pathways for CD14

	A-beta Uptake & Degradation
	Toll-Like receptor Signaling Pathways

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD14 (see all 8)

	iNOS Signaling
	LPS Stimulated MAPK Signaling
	MIF Regulation of Innate Immune Cells
	Toll-Like Receptors Pathway
	IL-10 Pathway

5/9 GeneGo (Thomson Reuters) Pathways for CD14 (see all 9)

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Immune response TLR signaling pathways
	Bacterial infections in CF airways

4 BioSystems Pathways for CD14

	MAPK signaling pathway
	Regulation of Actin Cytoskeleton
	Pathogenic Escherichia coli infection
	Toll-like receptor signaling pathway

5/19 Reactome Pathways for CD14 (see all 19)

	Auto-ubiquitination of TRAF3
	IKK complex recruitment mediated by RIP1
	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades

5/9 Kegg Pathways (Kegg details for CD14) (see all 9):

	MAPK signaling pathway
	Phagosome
	Toll-like receptor signaling pathway
	Hematopoietic cell lineage
	Regulation of actin cytoskeleton

CD14 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for CD14 (P08571^{2, 3} ENSP00000304236⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DIP2A	Q14689²^,³, ENSP00000392066⁴	MINT-7991045 I2D: score=1 STRING: ENSP00000392066
FSTL1	Q12841²^,³, ENSP00000295633⁴	MINT-7990653 MINT-7990768 MINT-8302262 I2D: score=1 STRING: ENSP00000295633
LBP	P18428³, ENSP00000217407⁴	I2D: score=3 STRING: ENSP00000217407
CD55	P08174³, ENSP00000316333⁴	I2D: score=2 STRING: ENSP00000316333
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=2 STRING: ENSP00000303242

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002237	response to molecule of bacterial origin	--	--
GO:0006909	phagocytosis	TAS	9548256
GO:0006915	apoptotic process	TAS	9548256
GO:0006950	response to stress	--	--
GO:0006954	inflammatory response	IEA	--

CD14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD14 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD14
10/99 Novoseek chemical compound relationships for CD14 gene (see all 99) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endotoxin	80.3	199	17949800 (6), 7694296 (5), 16614348 (3), 8798531 (3) (see all 99)
lipoteichoic acid	75.4	43	18458151 (5), 12594207 (4), 12011760 (3), 11559761 (3) (see all 15)
peptidoglycan	65.6	46	8798531 (4), 16239565 (3), 9535844 (2), 15358661 (2) (see all 20)
alpha-naphthyl butyrate	59.6	5	9737693 (1), 8639885 (1), 2070083 (1)
1,25 dihydroxy vitamin d3	50.5	7	18559006 (3), 15730927 (1), 9168815 (1)
nitroblue tetrazolium	50	6	11911463 (1), 15467202 (1), 9337080 (1), 12214860 (1) (see all 6)
polymyxin b	49.1	7	17854214 (2), 10966488 (1)
calcitriol	45.3	32	18495781 (4), 9773783 (4), 17327484 (3), 7522257 (2) (see all 17)
n-acetylmuramyl-l-alanyl-d-isoglutamine	44.9	1	11705912 (1)
fmlp	44.7	6	8933153 (1), 1370419 (1), 12747235 (1), 12094616 (1)

Search CenterWatch for drugs/clinical trials and news about CD14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD14 gene (4 alternative transcripts):

NM_000591.3 NM_001040021.2 NM_001174104.1 NM_001174105.1

Unigene Cluster for CD14:

CD14 molecule

Hs.163867 [show with all ESTs]

Unigene Representative Sequence: NM_001174104

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302014(uc003lgi.2) ENST00000498971 ENST00000519715 ENST00000512545

ENST00000401743(uc003lgj.2 uc021yej.1 uc021yek.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD14 Browse OriGene MicroRNA Expression Plasmids
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD14

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		GenScript: all cDNA clones in your preferred vector (see all 4): CD14 (NM_000591)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD14

Additional cDNA sequence:

AB446505.1 AF097942.1 AK313277.1 AY044269.1 BC010507.2 BT007331.1 M86511.1 X13334.1

11 DOTS entries:

DT.418882 DT.100880397 DT.95140005 DT.95140028 DT.100880401 DT.100880417 DT.120890632 DT.95140026

DT.100693968 DT.100880399 DT.100880396

24/503 AceView cDNA sequences (see all 503):

CD743250 CR609600 AL551553 CR620138 CR595571 CR612020 BM976443 CR600702

CR590334 BI823611 CA431640 T27019 AU135759 BX365015 BM708756 BI763624

BG058698 CB150493 AL544716 BX105955 CR600557 CB045465 CD370018 AL549182

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTCCAGCG

About this image

CD14 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Myeloid Dendritic Cells

Blood

Placenta

Chorionic Villus

Hofbauer Cells

Extraembryonic Tissues, Placenta

Umbilical Cord

Wharton's Jelly

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Liver

Sinusoids

Sinusoidal Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

Bone marrow-derived mesenchymal stem cells and myocytes (Ixmyelocel-T) (Adult Stem / Progenitor Cell)

Bone

Placenta-derived mesenchymal stem cells (Fetal Stem / Progenitor Cell)

Adipose, Bone, Cartilage, Extraembryonic Tissues

Bone marrow-derived mesenchymal stem cells (Lonza) (Adult Stem / Progenitor Cell)

Bone

Human bone marrow-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)

Bone

Mesenchymal stem cell (Adult Stem / Progenitor Cell)

Bone

Endothelial progenitor cells (Adult Stem / Progenitor Cell)

Endothelium

Placenta-derived adherent stromal cell (PLX) (Adult Stem / Progenitor Cell)

Extraembryonic Tissues, Placenta

Endometrial regenerative cell (Adult Stem / Progenitor Cell)

Reproductive System

Monocyte-like cells (Derivation of dendri...)

Macrophage-like cells (Generation of hemato...)

See CD14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD14

SOURCE GeneReport for Unigene cluster: Hs.163867

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571

Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also

expressed by most tissue macrophages

SABiosciences Expression via Pathway-Focused PCR Arrays including CD14 (see all 9):

Innate & Adaptive Immune Responses in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Antifungal Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD14 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd14^{1 , 5}	CD14 antigen^{1, 5}	73.24(n)¹ 67.12(a)¹		18 (19.46 cM)⁵ 12475¹ NM_009841.3¹ NP_033971.1¹ 36725067⁵
chicken (Gallus gallus)	Aves	CD14⁶	Uncharacterized protein	30(a)	1 ↔ 1	13(839963-863490)
lizard (Anolis carolinensis)	Reptilia	-- --	--	23(a) 21(a)	many → 1 many → 1	4(77746112-77747416) 4(77840680-77841999)
African clawed frog (Xenopus laevis)	Amphibia	BG552546.1²	--	71.21(n)		BG552546.1
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.13785²	Oncorhynchus mykiss transcribed sequence with weak more	70.82(n)		BX876915.1

ENSEMBL Gene Tree for CD14 (if available)
TreeFam Gene Tree for CD14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192496279^1,2		--	140010935(+)	`GTGTGA/TGAGAG`	4	--	ds500¹		0	--	--	--	--
rs139962474^1,2		--	140010983(+)	`TTTATC/TACCTT`	4	--	ds500¹		0	--	--	--	--
rs2563298^1,2	C,F,O,A,H,	--	140011315(+)	`ACGGAC/ACCGTT`	4	--	ut3¹		25		EA NA EU NS WA CSA	2648
rs3776138^1,2	C,H,	--	140011321(-)	`TTAAAC/GAACGG`	4	--	ut3¹		7		NA EU NS EA	506
rs5744456^1,2	C,F,H,	--	140011349(-)	`AACCCT/ATTGCC`	4	--	ut3¹		9		NA EU MN NS EA WA	790
rs144437953^1,2		--	140011363(+)	`TTGGTC/TGAAAA`	4	--	ut3¹		0	--	--	--	--
rs201259324^1,2	F	--	140011377(+)	`CTCAAC/TGTCCT`	4	--	ut3¹		1		EU	577
rs4914^1,2	C,F,A,H,	--	140011468(+)	`TGGAGC/GAGCAC`	8	L	syn¹ ese³		21		MN NA EU NS EA CSA WA	6840
rs11556179^1,2	C,F,H,	--	140011548(+)	`GCCCTC/TGTGGG`	8	K E	mis¹ ese³		6		NS EA NA	4930
rs77083413^1,2	C,	--	140011552(+)	`TCGTGG/CGGGAG`	8	/P	syn¹		2		EA NA	4644

HapMap Linkage Disequilibrium report for CD14 (140011313 - 140013286 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD14: --
Human Gene Mutation Database (HGMD): CD14

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD14 for disorders           About GeneDecksing

OMIM gene information: 158120    OMIM disorders: --

20/177 diseases for CD14 (see all 177):    About MalaCards

disseminated intravascular coagulation light chain deposition disease alpha 1-antitrypsin deficiency paroxysmal nocturnal hemoglobinuria

extrinsic allergic alveolitis diffuse large b-cell lymphoma complex regional pain syndrome human immunodeficiency virus infectious disease

wegener's granulomatosis otitis media burning mouth syndrome adult respiratory distress syndrome

graft versus host disease lichen planus monocytic leukemia b-cell lymphomas

acute monocytic leukemia clostridium difficile oral lichen planus myocardial infarction

10/93 Novoseek disease relationships for CD14 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	69.6	86	8975896 (2), 16148556 (2), 11477201 (2), 7685250 (2) (see all 75)
gram-negative bacterial infections	64.7	1	19109192 (1)
sepsis	62.6	70	19371402 (5), 14720421 (4), 9488406 (4), 18991094 (4) (see all 33)
monocytic leukemia	62.2	6	7510927 (1), 10547074 (1), 10488701 (1), 1493908 (1) (see all 5)
inflammation	57.2	40	11590384 (4), 19390489 (2), 16142747 (2), 12928151 (1) (see all 29)
shock septic	57	16	11219189 (3), 9553985 (2), 8833900 (2), 7688151 (2) (see all 11)
atopy	56.1	31	17949800 (2), 18312481 (2), 17877764 (2), 16306212 (2) (see all 21)
paroxysmal hemoglobinuria nocturnal	54.6	4	1376258 (1), 9488406 (1), 7537790 (1)
acute monocytic leukemia	50.9	2	7510927 (1)
asthma allergic	46.1	17	11590384 (3), 19148143 (2), 15378299 (2), 9551731 (2) (see all 9)

Genetic Association Database (GAD): CD14
Human Genome Epidemiology (HuGE) Navigator: CD14 (346 documents)

Export disorders for CD14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD14 gene, integrated from 9 sources (see all 1347):
(articles sorted by number of sources associating them with CD14)

Utopia: connect your pdf to the dynamic
world of online information

Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. (PubMed id 2472171)^{1, 2, 3} Setoguchi M....Yamamoto S. (1989)
Monocyte antigen CD14 is a phospholipid anchored membrane protein. (PubMed id 2462937)^{1, 2, 3} Simmons D.L.... Seed B. (1989)
CD14 expression on monocytes and soluble CD14 plasma levels in correlation to the promotor polymorphism of the endotoxin receptor CD14 gene in patients with inactive Crohn's disease. (PubMed id 15966209)^{1, 4, 9} Griga T....May B. (2005)
[CD14 genomic polymorphism influences CD14 expression in whole blood culture] (PubMed id 16194368)^{1, 4, 9} Lin J....Sheng Z.Y. (2005)
Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. (PubMed id 15655821)^{1, 4, 9} Gazouli M....Gorgoulis V.G. (2005)
Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection. (PubMed id 16273620)^{1, 4, 9} Meiler C....Hellerbrand C. (2005)
Lack of association between the -260 C-->T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels. (PubMed id 11810121)^{1, 4, 9} Heesen M....Kunz D. (2001)
Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan. (PubMed id 16292464)^{1, 4, 9} Tan C.Y....Wang J.Y. (2006)
NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? (PubMed id 15190267)^{1, 4, 9} Arnott I.D....Satsangi J. (2004)
Searching for links between endotoxin exposure and pregnancy loss: CD14 polymorphism in idiopathic recurrent miscarriage. (PubMed id 14672339)^{1, 4, 9} Karhukorpi J....Karttunen R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 929	HGNC: 1628	AceView: CD14	Ensembl:ENSG00000170458	euGenes: HUgn929
ECgene: CD14	Kegg: 929	H-InvDB: CD14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD14	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CD14

Intellectual Property for CD14 gene
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Patent Information for CD14 gene:
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