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Aliases for CD14 Gene

Aliases for CD14 Gene

  • CD14 Molecule 2 3
  • CD14 Antigen 2 4
  • Myeloid Cell-Specific Leucine-Rich Glycoprotein 4

External Ids for CD14 Gene

Previous GeneCards Identifiers for CD14 Gene

  • GC05M139827
  • GC05M139994
  • GC05M140039
  • GC05M139991
  • GC05M135156

Summaries for CD14 Gene

Entrez Gene Summary for CD14 Gene

  • The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for CD14 Gene

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include burning mouth syndrome and acute monocytic leukemia. Among its related pathways are MAPK signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

UniProtKB/Swiss-Prot for CD14 Gene

  • In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Gene Wiki entry for CD14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD14 Gene

Genomics for CD14 Gene

Regulatory Elements for CD14 Gene

Genomic Location for CD14 Gene

Start:
140,631,728 bp from pter
End:
140,633,701 bp from pter
Size:
1,974 bases
Orientation:
Minus strand

Genomic View for CD14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD14 Gene

Proteins for CD14 Gene

  • Protein details for CD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08571-CD14_HUMAN
    Recommended name:
    Monocyte differentiation antigen CD14
    Protein Accession:
    P08571
    Secondary Accessions:
    • Q53XT5
    • Q96FR6
    • Q96L99
    • Q9UNS3

    Protein attributes for CD14 Gene

    Size:
    375 amino acids
    Molecular mass:
    40076 Da
    Quaternary structure:
    • Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4

    Three dimensional structures from OCA and Proteopedia for CD14 Gene

neXtProt entry for CD14 Gene

Proteomics data for CD14 Gene at MOPED

Post-translational modifications for CD14 Gene

  • N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn37, Asn151, Asn282, Asn323, and Thr336
  • Modification sites at PhosphoSitePlus

Other Protein References for CD14 Gene

No data available for DME Specific Peptides for CD14 Gene

Domains for CD14 Gene

Gene Families for CD14 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD14 Gene

Suggested Antigen Peptide Sequences for CD14 Gene

Graphical View of Domain Structure for InterPro Entry

P08571

UniProtKB/Swiss-Prot:

CD14_HUMAN :
  • P08571
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CD14: view

Function for CD14 Gene

Molecular function for CD14 Gene

GENATLAS Biochemistry: cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction
UniProtKB/Swiss-Prot Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Gene Ontology (GO) - Molecular Function for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12594207
GO:0001847 opsonin receptor activity TAS 2402637
GO:0005515 protein binding IPI 20860622
GO:0016019 peptidoglycan receptor activity TAS 8798531
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with CD14: view
genes like me logo Genes that share phenotypes with CD14: view

Animal Models for CD14 Gene

MGI Knock Outs for CD14:

miRNA for CD14 Gene

miRTarBase miRNAs that target CD14

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD14 Gene

Localization for CD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD14 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD14 Gene COMPARTMENTS Subcellular localization image for CD14 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 4
cytosol 2
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with CD14: view

Pathways for CD14 Gene

genes like me logo Genes that share pathways with CD14: view

Gene Ontology (GO) - Biological Process for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006909 phagocytosis TAS 9548256
genes like me logo Genes that share ontologies with CD14: view

Compounds for CD14 Gene

(99) Novoseek inferred chemical compound relationships for CD14 Gene

Compound -log(P) Hits PubMed IDs
endotoxin 80.3 149
lipoteichoic acid 75.4 31
peptidoglycan 65.6 28
alpha-naphthyl butyrate 59.6 3
1,25 dihydroxy vitamin d3 50.5 5
genes like me logo Genes that share compounds with CD14: view

Transcripts for CD14 Gene

Unigene Clusters for CD14 Gene

CD14 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD14 Gene

No ASD Table

Relevant External Links for CD14 Gene

GeneLoc Exon Structure for
CD14
ECgene alternative splicing isoforms for
CD14

Expression for CD14 Gene

mRNA expression in normal human tissues for CD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD14 Gene

This gene is overexpressed in Whole Blood (14.7) and Liver (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD14 Gene

SOURCE GeneReport for Unigene cluster for CD14 Gene Hs.163867

mRNA Expression by UniProt/SwissProt for CD14 Gene

P08571-CD14_HUMAN
Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages
genes like me logo Genes that share expressions with CD14: view

Orthologs for CD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD14 35
  • 99.29 (n)
  • 98.93 (a)
CD14 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD14 35
  • 79.4 (n)
  • 75.28 (a)
CD14 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD14 35
  • 77.75 (n)
  • 71.55 (a)
mouse
(Mus musculus)
Mammalia Cd14 35
  • 72.99 (n)
  • 66.86 (a)
Cd14 16
Cd14 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD14 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD14 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd14 35
  • 72.32 (n)
  • 65.54 (a)
chicken
(Gallus gallus)
Aves CD14 36
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10497 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13785 35
Species with no ortholog for CD14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD14 Gene

ENSEMBL:
Gene Tree for CD14 (if available)
TreeFam:
Gene Tree for CD14 (if available)

Paralogs for CD14 Gene

No data available for Paralogs for CD14 Gene

Variants for CD14 Gene

Sequence variations from dbSNP and Humsavar for CD14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4914 -- 140,631,883(+) TGGAG(C/G)AGCAC synonymous-codon, reference
rs13763 -- 140,632,123(-) GCTGG(G/T)CTGGA reference, synonymous-codon
rs2228049 - 140,632,374(-) CTGAC(A/G)ATCCT reference, missense
rs2563298 -- 140,631,730(+) ACGGA(A/C)CCGTT utr-variant-3-prime
rs2563303 -- 140,633,126(+) CTTTA(C/G)GTTCT utr-variant-5-prime

Relevant External Links for CD14 Gene

HapMap Linkage Disequilibrium report
CD14
Human Gene Mutation Database (HGMD)
CD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD14 Gene

Disorders for CD14 Gene

(93) Novoseek inferred disease relationships for CD14 Gene

Disease -log(P) Hits PubMed IDs
necrosis 69.6 82
gram-negative bacterial infections 64.7 1
sepsis 62.6 55
monocytic leukemia 62.2 5
inflammation 57.2 34

Relevant External Links for CD14

Genetic Association Database (GAD)
CD14
Human Genome Epidemiology (HuGE) Navigator
CD14
genes like me logo Genes that share disorders with CD14: view

No data available for UniProtKB/Swiss-Prot for CD14 Gene

Publications for CD14 Gene

  1. Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease. (PMID: 11062291) Ito D. … Fukuuchi Y. (Stroke 2000) 3 23 48
  2. A prospective evaluation of the CD14 C(-260)T gene polymorphism and the risk of myocardial infarction. (PMID: 11257272) Zee R.Y. … Ridker P.M. (Atherosclerosis 2001) 3 23 48
  3. Association of a promoter polymorphism of the CD14 gene and atopy. (PMID: 11282774) Koppelman G.H. … Bleecker E.R. (Am. J. Respir. Crit. Care Med. 2001) 3 23 48
  4. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. (PMID: 11343243) JAorvelAoinen H.A. … Lindros K.O. (Hepatology 2001) 3 23 48
  5. [Molecular studies in a population of children with bronchial asthma. I. Polymorphism in the promotor region of gene CD14]. (PMID: 11732288) Lis G. … Pietrzyk J.J. (Pneumonol Alergol Pol 2001) 3 23 48

Products for CD14 Gene

  • Addgene plasmids for CD14

Sources for CD14 Gene

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