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CD14 Gene

protein-coding   GIFtS: 68
GCID: GC05M139991

CD14 Molecule

(Previous name: CD14 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD14 Molecule1 2
CD14 Antigen1 3
Myeloid Cell-Specific Leucine-Rich Glycoprotein2 3
Monocyte Differentiation Antigen CD142

External Ids:    HGNC: 16281   Entrez Gene: 9292   Ensembl: ENSG000001704587   OMIM: 1581205   UniProtKB: P085713   

Export aliases for CD14 gene to outside databases

Previous GC identifers: GC05M139827 GC05M140594 GC05M139994 GC05M140039 GC05M135156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD14 Gene:
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages.
It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide.
Alternative splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Mar
2010)

GeneCards Summary for CD14 Gene:
CD14 (CD14 molecule) is a protein-coding gene. Diseases associated with CD14 include light chain deposition disease, and burns. GO annotations related to this gene include lipoteichoic acid binding and lipopolysaccharide binding.

UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex,
thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and
TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell
surface molecules, including adhesion molecules

Gene Wiki entry for CD14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD14 gene promoter:
         CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD14 promoter sequence
   Search Chromatin IP Primers for CD14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3

CD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139991:  view genomic region     (about GC identifiers)

Start:
140,011,313 bp from pter      End:
140,013,286 bp from pter
Size:
1,974 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD14_HUMAN, P08571 (See protein sequence)
Recommended Name: Monocyte differentiation antigen CD14 precursor  
Size: 375 amino acids; 40076 Da
Subunit: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2
and TLR4
1 PDB 3D structure from and Proteopedia for CD14:
4GLP (3D)    
Secondary accessions: Q53XT5 Q96FR6 Q96L99 Q9UNS3

Explore the universe of human proteins at neXtProt for CD14: NX_P08571

Explore proteomics data for CD14 at MOPED

Post-translational modifications: 

  • N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan1
  • Glycosylation2 at Asn37, Asn151, Asn282, Asn323, Thr336
  • Modification sites at PhosphoSitePlus

  • See CD14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000582.1  NP_001035110.1  NP_001167575.1  NP_001167576.1  

    ENSEMBL proteins: 
     ENSP00000304236   ENSP00000426543   ENSP00000430884   ENSP00000425447   ENSP00000385519  
    Reactome Protein details: P08571

    CD14 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for CD14
    OriGene Purified Proteins for CD14
    OriGene Protein Over-expression Lysate for CD14
    OriGene MassSpec for CD14
    OriGene Custom Protein Services for CD14
    GenScript Custom Purified and Recombinant Proteins Services for CD14
    Novus Biologicals CD14 Proteins
    Novus Biologicals CD14 Lysates
    Sino Biological Recombinant Protein for CD14
    Sino Biological Cell Lysate for CD14
    ProSpec Recombinant Protein for CD14
    Cloud-Clone Corp. Proteins for CD14

    CD14 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD14
    R&D Systems Antibodies for CD14
    OriGene Antibodies for CD14
    OriGene Custom Antibody Services for CD14
    Novus Biologicals CD14 Antibodies
    Abcam antibodies for CD14
    Cloud-Clone Corp. Antibodies for CD14
    ThermoFisher Antibody for CD14
    LSBio Antibodies in human, mouse, rat for CD14

    CD14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD14
    R&D Systems ELISAs for CD14         (see all)
    GenScript Custom Assay Services for CD14
    Enzo Life Sciences assays for CD14
    Cloud-Clone Corp. ELISAs for CD14
    Cloud-Clone Corp. CLIAs for CD14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR016337 Monocyte_diff_Ag_CD14

    Graphical View of Domain Structure for InterPro Entry P08571

    ProtoNet protein and cluster: P08571

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
    Similarity: Contains 11 LRR (leucine-rich) repeats


    CD14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD14_HUMAN, P08571
    Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex,
    thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and
    TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell
    surface molecules, including adhesion molecules

         Genatlas biochemistry entry for CD14:
    cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of
    apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a
    liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies
    My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IDA12594207
    GO:0001847opsonin receptor activity TAS2402637
    GO:0005515protein binding IPI--
    GO:0016019peptidoglycan receptor activity TAS8798531
    GO:0070891lipoteichoic acid binding IDA12594207
         
    CD14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD14:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd14):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  respiratory system  skeleton 

    CD14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD14: Cd14tm1Smg Cd14tm1Frm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD14

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD14:
    hsa-mir-335-5p (MIRT016817)

    Block miRNA regulation of human, mouse, rat CD14 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CD14
    SwitchGear 3'UTR luciferase reporter plasmidCD14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD14
    Predesigned siRNA for gene silencing in human, mouse, rat CD14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD14

    Clone
    Products:
         
    OriGene clones in human, mouse for CD14 (see all 22)
    OriGene ORF clones in mouse, rat for CD14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD14 (NM_000591)
    Sino Biological Human cDNA Clone for CD14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD14
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD14_HUMAN, P08571: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular4
    cytosol2
    nucleus2
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0010008endosome membrane TAS--

    CD14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD14 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Transfer of LPS from LBP carrier to CD140.00
    Cytokine production by Th17 cells in CF Mouse model 0.72
    4Toll Comparative Pathway
    Toll Comparative Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    5NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CD14
        A-beta Uptake & Degradation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD14 (see all 8)
        iNOS Signaling
    LPS Stimulated MAPK Signaling
    MIF Regulation of Innate Immune Cells
    Toll-Like Receptors Pathway
    IL-10 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for CD14 (see all 9)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    5 BioSystems Pathways for CD14
        MAPK signaling pathway
    Toll-like receptor signaling pathway
    Regulation of Actin Cytoskeleton
    Pathogenic Escherichia coli infection
    Regulation of toll-like receptor signaling pathway


    Selected Reactome Pathways for CD14 (see all 10)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Transfer of LPS from LBP carrier to CD14
    TRIF-mediated programmed cell death


    Selected Kegg Pathways  (Kegg details for CD14) (see all 13):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Phagosome
    Toll-like receptor signaling pathway
    Hematopoietic cell lineage


    CD14 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD14 (see all 9): 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD14 (P085711, 2, 3 ENSP000003042364) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIP2AQ146892, 3, ENSP000003920664MINT-7991045 I2D: score=1 STRING: ENSP00000392066
    FSTL1Q128411, 2, 3, ENSP000002956334EBI-3905196,EBI-2349801 MINT-7990653 MINT-7990768 MINT-8302262 I2D: score=1 STRING: ENSP00000295633
    LBPP184283, ENSP000002174074I2D: score=3 STRING: ENSP00000217407
    CD55P081743, ENSP000003163334I2D: score=2 STRING: ENSP00000316333
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
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    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002237response to molecule of bacterial origin ----
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006909phagocytosis TAS9548256

    CD14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD14

    Selected Novoseek inferred chemical compound relationships for CD14 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 80.3 199 17949800 (6), 7694296 (5), 16614348 (3), 8798531 (3) (see all 99)
    lipoteichoic acid 75.4 43 18458151 (5), 12594207 (4), 12011760 (3), 11559761 (3) (see all 15)
    peptidoglycan 65.6 46 8798531 (4), 16239565 (3), 9535844 (2), 15358661 (2) (see all 20)
    alpha-naphthyl butyrate 59.6 5 9737693 (1), 8639885 (1), 2070083 (1)
    1,25 dihydroxy vitamin d3 50.5 7 18559006 (3), 15730927 (1), 9168815 (1)
    nitroblue tetrazolium 50 6 11911463 (1), 15467202 (1), 9337080 (1), 12214860 (1) (see all 6)
    polymyxin b 49.1 7 17854214 (2), 10966488 (1)
    calcitriol 45.3 32 18495781 (4), 9773783 (4), 17327484 (3), 7522257 (2) (see all 17)
    n-acetylmuramyl-l-alanyl-d-isoglutamine 44.9 1 11705912 (1)
    fmlp 44.7 6 8933153 (1), 1370419 (1), 12747235 (1), 12094616 (1)



    CD14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD14 gene (4 alternative transcripts): 
    NM_000591.3  NM_001040021.2  NM_001174104.1  NM_001174105.1  

    Unigene Cluster for CD14:

    CD14 molecule
    Hs.163867  [show with all ESTs]
    Unigene Representative Sequence: NM_001174104
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302014(uc003lgi.2) ENST00000498971 ENST00000519715 ENST00000512545
    ENST00000401743(uc003lgj.2 uc021yej.1 uc021yek.1)
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD14 (NM_000591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD14
    OriGene qSTAR qPCR primer pairs in human, mouse for CD14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD14
      QuantiTect SYBR Green Assays in human, mouse, rat CD14
      QuantiFast Probe-based Assays in human, mouse, rat CD14

    Additional mRNA sequence: 

    AB446505.1 AF097942.1 AK313277.1 AY044269.1 BC010507.2 BT007331.1 M86511.1 X13334.1 

    11 DOTS entries:

    DT.418882  DT.100880397  DT.95140005  DT.95140028  DT.100880401  DT.100880417  DT.120890632  DT.95140026 
    DT.100693968  DT.100880399  DT.100880396 

    Selected AceView cDNA sequences (see all 503):

    CR620234 BX365015 BI011476 CA413144 BU783861 AV684271 AL547752 CB148459 
    W56546 F04372 BI763624 BX105955 CD367928 CB119799 AL541515 BI825539 
    CD518812 CR614015 CR609600 T27019 CR613552 CA418638 CB124859 BM976443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCCAGCG
    CD14 Expression
    About this image


    CD14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 10 entries
             Monocytes Peripheral Blood
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
             Monocyte-like cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 11 entries
             Sinusoidal Endothelial Cells Sinusoids
             Peripheral blood-derived endothelial progenitor cells
             Purified endothelial-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 20 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 8 entries
             Hofbauer Cells Chorionic Villus
             Placenta-derived adherent stromal cell (PLX)
     
     Chorion (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hofbauer Cells Chorionic Villus
    CD14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.163867

    UniProtKB/Swiss-Prot: CD14_HUMAN, P08571
    Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also
    expressed by most tissue macrophages

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD14 (see all 9): 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Antifungal Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD14
    OriGene qSTAR qPCR primer pairs in human, mouse for CD14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD14
    QuantiTect SYBR Green Assays in human, mouse, rat CD14
    QuantiFast Probe-based Assays in human, mouse, rat CD14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD14 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd141 , 5 CD14 antigen1, 5 72.99(n)1
    66.86(a)1
      18 (19.46 cM)5
    124751  NM_009841.31  NP_033971.11 
     367250675 
    chicken
    (Gallus gallus)
    Aves CD146
    Gallus gallus CD14 molecule (CD14), mRNA.
    23(a)
    1 ↔ 1
    13(402430-403827)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    22(a)
    20(a)
    many → 1
    many → 1
    4(77746112-77747416)
    4(77840668-77842038)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG552546.12   -- 71.21(n)    BG552546.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.137852 Oncorhynchus mykiss transcribed sequence with weak more 70.82(n)    BX876915.1 


    ENSEMBL Gene Tree for CD14 (if available)
    TreeFam Gene Tree for CD14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD14 (see all 136)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924962791,2
    --140287578(+) GTGTGA/TGAGAG 4 -- ds50010--------
    rs1399624741,2
    --140287626(+) TTTATC/TACCTT 4 -- ds50010--------
    rs25632981,2
    C,F,O,A,H--140287958(+) ACGGAC/ACCGTT 4 -- ut3125Minor allele frequency- A:0.19EA NA EU NS WA CSA 2648
    rs37761381,2
    C,F,H--140287964(-) TTAAAC/GAACGG 4 -- ut317Minor allele frequency- G:0.00NA EU NS EA 506
    rs57444561,2
    C,F,H--140287992(-) AACCCT/ATTGCC 4 -- ut319Minor allele frequency- A:0.03NA EU MN NS EA WA 790
    rs1444379531,2
    --140288006(+) TTGGTC/TGAAAA 4 -- ut310--------
    rs2012593241,2
    F--140288020(+) CTCAAC/TGTCCT 4 -- ut311Minor allele frequency- T:0.00EU 577
    rs49141,2
    C,F,A,H--140288111(+) TGGAGC/GAGCAC 8 L syn1 ese321Minor allele frequency- G:0.11MN NA EU NS EA CSA WA 6840
    rs3750454201,2
    C--140288137(+) CCCCAC/TCGACA 8 M V mis10--------
    rs115561791,2,,4
    C,F,H--140288191(+) GCCCTC/TGTGGG 8 K E mis1 ese36Minor allele frequency- T:0.00NS EA NA 4930

    HapMap Linkage Disequilibrium report for CD14 (140011313 - 140013286 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD14: --
    Human Gene Mutation Database (HGMD): CD14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD14
    DNA2.0 Custom Variant and Variant Library Synthesis for CD14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 158120    OMIM disorders: --

    Selected diseases for CD14 (see all 182):    
    About MalaCards
    light chain deposition disease    burns    acute monocytic leukemia    burning mouth syndrome
    monocytic leukemia    extrinsic allergic alveolitis    cardiogenic shock    viral meningitis
    sepsis    preterm premature rupture of the membranes    bone fracture    al amyloidosis
    pouchitis    brucellosis    food allergy    hemoglobinuria
    carotid artery disease    peptic ulcer    otitis media    atopy


    CD14 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD14 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 69.6 86 8975896 (2), 16148556 (2), 11477201 (2), 7685250 (2) (see all 75)
    gram-negative bacterial infections 64.7 1 19109192 (1)
    sepsis 62.6 70 19371402 (5), 14720421 (4), 9488406 (4), 18991094 (4) (see all 33)
    monocytic leukemia 62.2 6 7510927 (1), 10547074 (1), 10488701 (1), 1493908 (1) (see all 5)
    inflammation 57.2 40 11590384 (4), 19390489 (2), 16142747 (2), 12928151 (1) (see all 29)
    shock septic 57 16 11219189 (3), 9553985 (2), 8833900 (2), 7688151 (2) (see all 11)
    atopy 56.1 31 17949800 (2), 18312481 (2), 17877764 (2), 16306212 (2) (see all 21)
    paroxysmal hemoglobinuria nocturnal 54.6 4 1376258 (1), 9488406 (1), 7537790 (1)
    acute monocytic leukemia 50.9 2 7510927 (1)
    asthma allergic 46.1 17 11590384 (3), 19148143 (2), 15378299 (2), 9551731 (2) (see all 9)

    Genetic Association Database (GAD): CD14
    Human Genome Epidemiology (HuGE) Navigator: CD14 (346 documents)

    Export disorders for CD14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD14 gene, integrated from 10 sources (see all 1387):
    (articles sorted by number of sources associating them with CD14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. (PubMed id 2472171)1, 2, 3 Setoguchi M....Yamamoto S. (Biochim. Biophys. Acta 1989)
    2. Monocyte antigen CD14 is a phospholipid anchored membrane protein. (PubMed id 2462937)1, 2, 3 Simmons D.L.... Seed B. (Blood 1989)
    3. CD14 expression on monocytes and soluble CD14 plasma levels in correlation to the promotor polymorphism of the endotoxin receptor CD14 gene in patients with inactive Crohn's disease. (PubMed id 15966209)1, 4, 9 Griga T....May B. (Hepatogastroenterology 2005)
    4. CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? (PubMed id 20398919)1, 4, 9 Munthe-Kaas M.C....Lyle R. (J. Allergy Clin. Immunol. 2010)
    5. Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (PubMed id 17949800)1, 4, 9 Levan T.D....Martinez F.D. (J. Allergy Clin. Immunol. 2008)
    6. [CD14 genomic polymorphism influences CD14 expression in whole blood culture]. (PubMed id 16194368)1, 4, 9 Lin J....Sheng Z.Y. (Zhonghua Wai Ke Za Zhi 2005)
    7. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. (PubMed id 15655821)1, 4, 9 Gazouli M....Gorgoulis V.G. (World J. Gastroenterol. 2005)
    8. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PubMed id 18951711)1, 4, 9 Lin J....Sheng Z.Y. (Burns 2009)
    9. [The influence of CD14 genomic polymorphism on CD14 gene expression as well as protein release and its clinical significance in patients with extensive burns]. (PubMed id 17067484)1, 4, 9 Lin J....Sheng Z.Y. (Zhonghua Wai Ke Za Zhi 2006)
    10. Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection. (PubMed id 16273620)1, 4, 9 Meiler C....Hellerbrand C. (World J. Gastroenterol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 929 HGNC: 1628 AceView: CD14 Ensembl:ENSG00000170458 euGenes: HUgn929
    ECgene: CD14 Kegg: 929 H-InvDB: CD14

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD14

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD14 gene:
    Search GeneIP for patents involving CD14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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