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Aliases for CD109 Gene

Aliases for CD109 Gene

  • CD109 Molecule 2 3
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 7 3 4
  • 150 KDa TGF-Beta-1-Binding Protein 3 4
  • Platelet-Specific Gov Antigen 3 4
  • CD109 Antigen 3 4
  • CPAMD7 3 4
  • P180 3 4
  • R150 3 4
  • CD109 Antigen (Gov Platelet Alloantigens) 2
  • Activated T-Cell Marker CD109 3
  • Gov Platelet Alloantigens 3

External Ids for CD109 Gene

Previous GeneCards Identifiers for CD109 Gene

  • GC06P074364
  • GC06P074401
  • GC06P074462
  • GC06P071605

Summaries for CD109 Gene

Entrez Gene Summary for CD109 Gene

  • This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for CD109 Gene

CD109 (CD109 Molecule) is a Protein Coding gene. Diseases associated with CD109 include fetal and neonatal alloimmune thrombocytopenia. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is C3.

UniProtKB/Swiss-Prot for CD109 Gene

  • Modulates negatively TGFB1 signaling in keratinocytes.

Gene Wiki entry for CD109 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD109 Gene

Genomics for CD109 Gene

Regulatory Elements for CD109 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD109 Gene

73,695,785 bp from pter
73,828,317 bp from pter
132,533 bases
Plus strand

Genomic View for CD109 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD109 Gene

Proteins for CD109 Gene

  • Protein details for CD109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD109 antigen
    Protein Accession:
    Secondary Accessions:
    • A5YKK4
    • B2R948
    • B3KW25
    • Q0P6K7
    • Q5SYA8
    • Q5XUM7
    • Q5XUM9
    • Q6MZI7
    • Q8N3A7
    • Q8N915
    • Q8TDJ2
    • Q8TDJ3

    Protein attributes for CD109 Gene

    1445 amino acids
    Molecular mass:
    161689 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.
    • Sequence=BAG53987.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE46045.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE46045.1; Type=Frameshift; Positions=1282; Evidence={ECO:0000305};

    Alternative splice isoforms for CD109 Gene


neXtProt entry for CD109 Gene

Proteomics data for CD109 Gene at MOPED

Post-translational modifications for CD109 Gene

  • 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form
  • N-glycosylated.
  • Glycosylation at Asn68, Asn118, Asn247, Asn279, Asn365, Asn419, Asn645, and Asn1086
  • Modification sites at PhosphoSitePlus

Other Protein References for CD109 Gene

Antibody Products

No data available for DME Specific Peptides for CD109 Gene

Domains for CD109 Gene

Gene Families for CD109 Gene

Suggested Antigen Peptide Sequences for CD109 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with CD109: view

Function for CD109 Gene

Molecular function for CD109 Gene

UniProtKB/Swiss-Prot Function:
Modulates negatively TGFB1 signaling in keratinocytes.

Gene Ontology (GO) - Molecular Function for CD109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0050431 transforming growth factor beta binding IPI 16754747
genes like me logo Genes that share ontologies with CD109: view
genes like me logo Genes that share phenotypes with CD109: view

Animal Model Products

miRNA for CD109 Gene

miRTarBase miRNAs that target CD109

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD109

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CD109 Gene

Localization for CD109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD109 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for CD109 Gene COMPARTMENTS Subcellular localization image for CD109 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19581412
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CD109: view

Pathways for CD109 Gene

SuperPathways for CD109 Gene

No Data Available

Interacting Proteins for CD109 Gene

Gene Ontology (GO) - Biological Process for CD109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001942 hair follicle development IEA --
GO:0010839 negative regulation of keratinocyte proliferation IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 16754747
genes like me logo Genes that share ontologies with CD109: view

No data available for Pathways by source for CD109 Gene

Transcripts for CD109 Gene

Unigene Clusters for CD109 Gene

CD109 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD109

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD109 Gene

No ASD Table

Relevant External Links for CD109 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD109 Gene

mRNA expression in normal human tissues for CD109 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CD109 Gene

This gene is overexpressed in Serum (18.7), Liver (13.9), and Hair follicle (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD109 Gene

SOURCE GeneReport for Unigene cluster for CD109 Gene Hs.399891

mRNA Expression by UniProt/SwissProt for CD109 Gene

Tissue specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.
genes like me logo Genes that share expressions with CD109: view

Expression partners for CD109 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD109 Gene

Orthologs for CD109 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD109 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD109 35
  • 87.31 (n)
  • 85.93 (a)
CD109 36
  • 85 (a)
(Canis familiaris)
Mammalia CD109 35
  • 89.92 (n)
  • 87.89 (a)
CD109 36
  • 88 (a)
(Mus musculus)
Mammalia Cd109 35
  • 79.51 (n)
  • 72.99 (a)
Cd109 16
Cd109 36
  • 72 (a)
(Pan troglodytes)
Mammalia CD109 35
  • 99.35 (n)
  • 99.03 (a)
CD109 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cd109 35
  • 77.89 (n)
  • 70.17 (a)
(Monodelphis domestica)
Mammalia CD109 36
  • 69 (a)
(Gallus gallus)
Aves CD109 35
  • 65 (n)
  • 57.4 (a)
CD109 36
  • 56 (a)
(Anolis carolinensis)
Reptilia CD109 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486953 35
  • 59.83 (n)
  • 49.34 (a)
(Danio rerio)
Actinopterygii cd109 35
  • 50.84 (n)
  • 42.74 (a)
CD109 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcr 37
  • 25 (a)
TepI 37
  • 29 (a)
TepII 37
  • 30 (a)
TepIII 37
  • 27 (a)
TepIV 37
  • 28 (a)
Tep3 35
  • 42.48 (n)
  • 30.79 (a)
CG13079 36
  • 21 (a)
TepI 36
  • 29 (a)
TepII 36
  • 30 (a)
TepIII 36
  • 27 (a)
TepIV 36
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TEP15 35
  • 45.75 (n)
  • 36.79 (a)
(Caenorhabditis elegans)
Secernentea ZK337.1a 37
  • 31 (a)
ZK337.1b 37
  • 31 (a)
tep-1 35
  • 46.57 (n)
  • 35.41 (a)
tep-1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6169 36
  • 24 (a)
Species with no ortholog for CD109:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD109 Gene

Gene Tree for CD109 (if available)
Gene Tree for CD109 (if available)

Paralogs for CD109 Gene

Paralogs for CD109 Gene

genes like me logo Genes that share paralogs with CD109: view

Variants for CD109 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD109 Gene

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants

Sequence variations from dbSNP and Humsavar for CD109 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs34526009 -- 73,702,031(+) GGTTT(-/T)GGGGG intron-variant
rs34458390 -- 73,799,856(+) CCCGC(-/C)AATTT intron-variant
rs34442668 -- 73,781,519(+) CTGTC(-/C)TAGAT intron-variant
rs34427945 -- 73,767,076(+) AAGTT(-/A)CTGGG intron-variant
rs34363632 -- 73,706,687(+) CAGTA(A/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD109 Gene

Variant ID Type Subtype PubMed ID
nsv886158 CNV Gain 21882294
nsv463154 CNV Gain 19166990
esv2499472 CNV Deletion 19546169
esv2379909 CNV Deletion 18987734
esv2732297 CNV Deletion 23290073
esv9431 CNV Loss 19470904
esv1316113 CNV Deletion 17803354
nsv348528 CNV Loss 16902084
nsv527906 CNV Loss 19592680
nsv528148 CNV Loss 19592680
esv29490 CNV Gain 19812545
esv268307 CNV Insertion 20981092
esv274437 CNV Insertion 20981092

Relevant External Links for CD109 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CD109 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD109 Gene in MalaCards »

(1) Disease for CD109 Gene

(2) Novoseek inferred disease relationships for CD109 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 33.7 10
adenocarcinoma 31.5 2

Relevant External Links for CD109

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD109: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CD109 Gene

Publications for CD109 Gene

  1. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. (PMID: 11861285) Schuh A.C. … Ouwehand W.H. (Blood 2002) 2 3 4 23
  2. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. (PMID: 11861284) Lin M. … Schuh A.C. (Blood 2002) 2 3 4
  3. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. (PMID: 16754747) Finnson K.W. … Philip A. (FASEB J. 2006) 3 4
  4. Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians. (PMID: 15569238) Cardone J.D. … Bordin J.O. (Transfus Med 2004) 3 48
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 3 4

Products for CD109 Gene

  • Addgene plasmids for CD109

Sources for CD109 Gene

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