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CD109 Gene

protein-coding   GIFtS: 55
GCID: GC06P074462

CD109 Molecule

(Previous name: CD109 antigen (Gov platelet alloantigens))
  See CD109-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD109 Molecule1 2     p1802 3
Platelet-Specific Gov Antigen2 3     r1502 3
150 KDa TGF-Beta-1-Binding Protein2 3     CD109 Antigen (Gov Platelet Alloantigens)1
CPAMD72 3     Activated T-Cell Marker CD1092
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 72 3     Gov Platelet Alloantigens2
CD109 Antigen2 3     

External Ids:    HGNC: 216851   Entrez Gene: 1352282   Ensembl: ENSG000001565357   OMIM: 6088595   UniProtKB: Q6YHK33   

Export aliases for CD109 gene to outside databases

Previous GC identifers: GC06P074364 GC06P074401 GC06P071605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD109 Gene:
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein
is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and
negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants
encoding different isoforms have been found for this gene.(provided by RefSeq, Apr 2009)

GeneCards Summary for CD109 Gene:
CD109 (CD109 molecule) is a protein-coding gene. Diseases associated with CD109 include fetal and neonatal alloimmune thrombocytopenia. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
Function: Modulates negatively TGFB1 signaling in keratinocytes

Gene Wiki entry for CD109 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD109 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-4   E2F-2   POU2F1   E2F-1   E2F   c-Myb   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD109 promoter sequence
   Search Chromatin IP Primers for CD109

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD109


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q14.1

CD109 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD109 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P074462:  view genomic region     (about GC identifiers)

Start:
74,405,508 bp from pter      End:
74,538,041 bp from pter
Size:
132,534 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3 (See protein sequence)
Recommended Name: CD109 antigen precursor  
Size: 1445 amino acids; 161689 Da
Subunit: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1,
TGFBR2 and TGFBR3 in a ligand-independent manner
Sequence caution: Sequence=BAG53987.1; Type=Erroneous initiation; Sequence=CAE46045.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAE46045.1; Type=Frameshift; Positions=1282;
Secondary accessions: A5YKK4 B2R948 B3KW25 Q0P6K7 Q5SYA8 Q5XUM7 Q5XUM9 Q6MZI7 Q8N3A7 Q8N915
Q8TDJ2 Q8TDJ3
Alternative splicing: 4 isoforms:  Q6YHK3-1   Q6YHK3-2   Q6YHK3-3   Q6YHK3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD109: NX_Q6YHK3

Explore proteomics data for CD109 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form1
  • Glycosylation2 at Asn68, Asn118, Asn247, Asn279, Asn365, Asn419, Asn645, Asn1086
  • Modification sites at PhosphoSitePlus

  • See CD109 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153059.1  NP_001153060.1  NP_598000.2  

    ENSEMBL proteins: 
     ENSP00000287097   ENSP00000388062   ENSP00000404475  

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    Cloud-Clone Corp. Proteins for CD109

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N
     IPR009048 A-macroglobulin_rcpt-bd

    Graphical View of Domain Structure for InterPro Entry Q6YHK3

    ProtoNet protein and cluster: Q6YHK3

    2 Blocks protein domains:
    IPB001599 Alpha-2-macroglobulin
    IPB002890 Alpha-2-macroglobulin


    UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    Find genes that share domains with CD109           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD109_HUMAN, Q6YHK3
    Function: Modulates negatively TGFB1 signaling in keratinocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0050431transforming growth factor beta binding IPI16754747
         
    Find genes that share ontologies with CD109           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd109):
     endocrine/exocrine gland  immune system  integument 

    Find genes that share phenotypes with CD109           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD109
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD109
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    miRNA
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    miRTarBase miRNAs that target CD109:
    hsa-mir-155-5p (MIRT020701), hsa-mir-1 (MIRT023686)

    Block miRNA regulation of human, mouse, rat CD109 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD109 (see all 26):
    hsa-miR-495 hsa-miR-3607-5p hsa-miR-875-3p hsa-miR-185* hsa-miR-340 hsa-miR-421 hsa-miR-570 hsa-miR-3154
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat CD109

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD109_HUMAN, Q6YHK3: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with CD109           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD109
    Interactions:

        GeneGlobe Interaction Network for CD109

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IDA16754747
    GO:0061045negative regulation of wound healing IDA16754747

    Find genes that share ontologies with CD109           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD109



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD109 gene (3 alternative transcripts): 
    NM_001159587.1  NM_001159588.1  NM_133493.3  

    Unigene Cluster for CD109:

    CD109 molecule
    Hs.399891  [show with all ESTs]
    Unigene Representative Sequence: NM_133493
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287097 ENST00000474094 ENST00000437994(uc003phq.3 uc003php.3)
    ENST00000422508(uc010kba.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CD109 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD109 (see all 26):
    hsa-miR-495 hsa-miR-3607-5p hsa-miR-875-3p hsa-miR-185* hsa-miR-340 hsa-miR-421 hsa-miR-570 hsa-miR-3154
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD109
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD109
      QuantiTect SYBR Green Assays in human, mouse, rat CD109
      QuantiFast Probe-based Assays in human, mouse, rat CD109

    Additional mRNA sequence: 

    AF410459.1 AK095888.1 AK123960.1 AK130104.1 AK313636.1 AL110152.1 AL834478.1 AY149920.1 
    AY374441.2 AY374442.1 AY788891.1 BX641095.1 EF553520.1 

    5 DOTS entries:

    DT.411247  DT.101961256  DT.100786952  DT.117452  DT.40115866 

    Selected AceView cDNA sequences (see all 182):

    BX475936 D79933 CB132631 BQ775821 AI023934 AI022608 BU687393 AK130104 
    AA512882 CA435508 AA844126 AI082553 AI129292 AI382712 AI206246 N52362 
    BP351431 AW197629 BU634432 AA846729 AL110152 N35347 AI026964 CB853216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD109 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTATTAAT
    CD109 Expression
    About this image


    CD109 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Lung (Respiratory System)
             Basal Cells Trachea
    CD109 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD109 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.399891

    UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
    Tissue specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal
    heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines,
    activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform
    1 is expressed in keratinocytes and placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD109 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1091 , 5 CD109 antigen1, 5 79.51(n)1
    72.99(a)1
      9 (43.65 cM)5
    2355051  NM_153098.31  NP_694738.11 
     786155465 
    chicken
    (Gallus gallus)
    Aves CD1091 CD109 molecule 65(n)
    57.4(a)
      421862  XM_004940429.1  XP_004940486.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD1096
    CD109 molecule
    54(a)
    1 ↔ 1
    1(41911014-41975269)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004869531 uncharacterized LOC100486953 59.83(n)
    49.34(a)
      100486953  XM_002937148.2  XP_002937194.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cd1091 CD109 molecule 50.84(n)
    42.74(a)
      569058  XM_692420.6  XP_697512.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta TepII3
    Tep31
    antibacterial humoral response (sensu
    Invertebrata) more3
    Thioester-containing protein 31
    30(a)
    (best of 5)3
    42.48(n)1
    30.79(a)1
      28C13
    340451  NM_078783.21  NP_523507.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK337.1b3
    tep-11
    Alpha-2-macroglobulin family (3
    domains)3
    tep-11
    31(a)
    (best of 2)3
    46.57(n)1
    35.41(a)1
      I(15002814-15009494)3
    1733671  NM_001026696.31  NP_001021867.11 


    ENSEMBL Gene Tree for CD109 (if available)
    TreeFam Gene Tree for CD109 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD109 gene
    A2M2  C52  C32  C4B2  C4A2  A2ML12  PZP2  CPAMD82  

    Find genes that share paralogs with CD109           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CD109_HUMAN, Q6YHK3: The Gov(b) variant in position 703 defines the Gov alloantigenic determinants


    Selected SNPs for CD109 (see all 2890)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362364
    A colorectal cancer sample4--see VAR_0362362 Q E mis40--------
    VAR_0362374
    A colorectal cancer sample4--see VAR_0362372 N K mis40--------
    rs360138501,2
    C--74404801(+) CATAG-/CTTTGT 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs58773781,2
    C--74405264(+) TCTTC-/TTTTTT 3 -- us2k1 trp30--------
    rs346837641,2
    C--74409976(+) TAAAA-/TTTTTT 3 -- int10--------
    rs1995759371,2
    C--74421264(+) TTTTTA/TTTTTT 3 -- int10--------
    rs30458551,2
    C--74421932(-) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    6 -- int1 cds12NA CSA 4
    rs38467541,2
    F--74433011(-) AAAAAA/GGAAAC 3 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.03WA 118
    rs1879688081,2
    --74433052(+) TGAGAC/TGGAGT 3 -- us2k10--------
    rs1927743401,2
    --74433080(+) GGCTGC/GAGAGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD109 (74405508 - 74538041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CD109 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2499472CNV Deletion19546169
    esv2732297CNV Deletion23290073
    esv2379909CNV Deletion18987734
    esv1316113CNV Deletion17803354
    esv274437CNV Insertion20981092
    esv268307CNV Insertion20981092
    nsv348528CNV Loss16902084
    nsv528148CNV Loss19592680
    nsv527906CNV Loss19592680
    esv9431CNV Loss19470904

    Human Gene Mutation Database (HGMD): CD109
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608859    OMIM disorders: --

    1 disease for CD109:    
    About MalaCards
    fetal and neonatal alloimmune thrombocytopenia


    Find genes that share disorders with CD109           About GenesLikeMe

    2 Novoseek inferred disease relationships for CD109 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 33.7 13 17922683 (4), 15826242 (3), 15116102 (3)
    adenocarcinoma 31.5 3 17922683 (1), 15116102 (1)

    Genetic Association Database (GAD): CD109
    Human Genome Epidemiology (HuGE) Navigator: CD109 (7 documents)

    Export disorders for CD109 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD109 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with CD109)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. (PubMed id 11861285)1, 2, 3, 9 Schuh A.C.... Ouwehand W.H. (Blood 2002)
    2. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. (PubMed id 11861284)1, 2, 3 Lin M.... Schuh A.C. (Blood 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human platelet antigen polymorphisms (HPA-1, -2, -3, -4, -5 and -15) in major ethnic groups of Pakistan. (PubMed id 19948007)1, 4 Bhatti F.A....Bugert P. (Transfus Med 2010)
    5. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    6. Simultaneous genotyping of human platelet antigen-1 to 17w by polymerase chain reaction sequence-based typing. (PubMed id 19570064)1, 4 Xu X....Yan L. (Vox Sang. 2009)
    7. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    8. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)1, 2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. (PubMed id 16754747)1, 2 Finnson K.W.... Philip A. (FASEB J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 135228 HGNC: 21685 AceView: CD109.1 Ensembl:ENSG00000156535 euGenes: HUgn135228
    ECgene: CD109 H-InvDB: CD109

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD109 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD109 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD109 gene:
    Search GeneIP for patents involving CD109

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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