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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD109 Gene

protein-coding   GIFtS: 54
GCID: GC06P074462

CD109 Molecule

(Previous name: CD109 antigen (Gov platelet alloantigens))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD109 Molecule1 2     p1802 3
Platelet-Specific Gov Antigen2 3     r1502 3
150 KDa TGF-Beta-1-Binding Protein2 3     CD109 Antigen (Gov Platelet Alloantigens)1
CPAMD72 3     RP11-525G3.12
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 72 3     Activated T-Cell Marker CD1092
CD109 Antigen2 3     Gov Platelet Alloantigens2

External Ids:    HGNC: 216851   Entrez Gene: 1352282   Ensembl: ENSG000001565357   OMIM: 6088595   UniProtKB: Q6YHK33   

Export aliases for CD109 gene to outside databases

Previous GC identifers: GC06P074364 GC06P074401 GC06P071605


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD109 Gene:
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein
is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and
negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants
encoding different isoforms have been found for this gene.(provided by RefSeq, Apr 2009)

GeneCards Summary for CD109 Gene: 
CD109 (CD109 molecule) is a protein-coding gene. Diseases associated with CD109 include lung squamous cell carcinoma, and purpura. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
Function: Modulates negatively TGFB1 signaling in keratinocytes

Gene Wiki entry for CD109 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD109 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-4   E2F-2   POU2F1   E2F-1   E2F   c-Myb   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD109 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD109

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD109


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q14.1

CD109 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD109 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P074462:  view genomic region     (about GC identifiers)

Start:
74,405,508 bp from pter      End:
74,538,041 bp from pter
Size:
132,534 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3 (See protein sequence)
Recommended Name: CD109 antigen precursor  
Size: 1445 amino acids; 161689 Da
Subunit: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1,
TGFBR2 and TGFBR3 in a ligand-independent manner
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence caution: Sequence=BAG53987.1; Type=Erroneous initiation; Sequence=CAE46045.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAE46045.1; Type=Frameshift; Positions=1282;
Secondary accessions: A5YKK4 B2R948 B3KW25 Q0P6K7 Q5SYA8 Q5XUM7 Q5XUM9 Q6MZI7 Q8N3A7 Q8N915
Q8TDJ2 Q8TDJ3
Alternative splicing: 4 isoforms:  Q6YHK3-1   Q6YHK3-2   Q6YHK3-3   Q6YHK3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD109: NX_Q6YHK3

Explore proteomics data for CD109 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6YHK3

  • CD109 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD109 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001153059.1  NP_001153060.1  NP_598000.2  

    ENSEMBL proteins: 
     ENSP00000287097   ENSP00000388062   ENSP00000404475  

    Human Recombinant Protein Products for CD109: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD109 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0031225anchored to membrane IEA--

    CD109 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CD109


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    5/8 InterPro protein domains (see all 8):
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N
     IPR009048 A-macroglobulin_rcpt-bd
     IPR019565 MacrogloblnA2_thiol-ester-bond

    Graphical View of Domain Structure for InterPro Entry Q6YHK3

    ProtoNet protein and cluster: Q6YHK3

    2 Blocks protein domains:
    IPB001599 Alpha-2-macroglobulin
    IPB002890 Alpha-2-macroglobulin


    UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    CD109 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD109_HUMAN, Q6YHK3
    Function: Modulates negatively TGFB1 signaling in keratinocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    CD109 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd109):
     endocrine/exocrine gland  immune system  integument 

    CD109 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD109 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD109

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD109 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD109 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD109
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD109 (see all 26):
    hsa-miR-495 hsa-miR-3607-5p hsa-miR-875-3p hsa-miR-185* hsa-miR-340 hsa-miR-421 hsa-miR-570 hsa-miR-3154
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD109

    Clone
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    OriGene ORF clones in mouse, rat for CD109
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    Sino Biological Human cDNA Clone for CD109
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                         Customized lentivirus expression plasmids for stable overexpression of CD109 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD109


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD109

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD109

    Search CenterWatch for drugs/clinical trials and news about CD109

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD109 gene (3 alternative transcripts): 
    NM_001159587.1  NM_001159588.1  NM_133493.3  

    Unigene Cluster for CD109:

    CD109 molecule
    Hs.399891  [show with all ESTs]
    Unigene Representative Sequence: NM_133493
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287097 ENST00000474094 ENST00000437994(uc003phq.3 uc003php.3)
    ENST00000422508(uc010kba.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD109
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD109 (see all 26):
    hsa-miR-495 hsa-miR-3607-5p hsa-miR-875-3p hsa-miR-185* hsa-miR-340 hsa-miR-421 hsa-miR-570 hsa-miR-3154
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD109
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD109
    Clone
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    OriGene clones in human, mouse for CD109 (see all 15)
    OriGene ORF clones in mouse, rat for CD109
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD109 (NM_133493)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD109
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD109
    Sirion Biotech Customized lentivirus for stable overexpression of CD109 
                         Customized lentivirus expression plasmids for stable overexpression of CD109 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD109
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD109
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD109

    Additional mRNA sequence: 

    AF410459.1 AK095888.1 AK123960.1 AK130104.1 AK313636.1 AL110152.1 AL834478.1 AY149920.1 
    AY374441.2 AY374442.1 AY788891.1 BX641095.1 EF553520.1 

    5 DOTS entries:

    DT.411247  DT.101961256  DT.100786952  DT.117452  DT.40115866 

    24/182 AceView cDNA sequences (see all 182):

    AI378219 AI022608 AI026963 AW197629 AI275388 BU687393 N35347 AA843263 
    BQ775821 AA846729 BF434900 N52362 BX475936 AI082553 AW235807 BM722643 
    CA435508 AA028004 AI129292 CA420610 AI023934 BP351431 AA512882 AL110152 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD109 expression in normal human tissues (normalized intensities)      CD109 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTATTAAT
    CD109 Expression
    About this image


    CD109 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Fibroblast
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node

    See CD109 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD109

    SOURCE GeneReport for Unigene cluster: Hs.399891

    UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
    Tissue specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal
    heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines,
    activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform
    1 is expressed in keratinocytes and placenta

        SABiosciences Custom PCR Arrays for CD109
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD109

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD109 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1091 , 5 CD109 antigen1, 5 79.48(n)1
    72.99(a)1
      9 (43.65 cM)5
    2355051  NM_153098.31  NP_694738.11 
     786155465 
    chicken
    (Gallus gallus)
    Aves CD1091 CD109 molecule 64.57(n)
    56.91(a)
      421862  XM_419879.3  XP_419879.3 
    lizard
    (Anolis carolinensis)
    Reptilia CD1096
    Uncharacterized protein
    54(a)
    1 ↔ 1
    1(41911014-41975269)
    zebrafish
    (Danio rerio)
    Actinopterygii cd1091 CD109 molecule 50.75(n)
    42.04(a)
      569058  XM_692420.5  XP_697512.5 
    mosquito
    (Anopheles gambiae)
    Insecta TEP151 AGAP008364-PA 45.37(n)
    36.1(a)
      1277615  XM_317088.2  XP_317088.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK337.1b3
    tep-11
    Alpha-2-macroglobulin family (3
    domains)3
    Protein TEP-11
    31(a)
    (best of 2)3
    46.56(n)1
    35.14(a)1
      I(15002814-15009494)3
    1733671  NM_001026696.21  NP_001021867.11 


    ENSEMBL Gene Tree for CD109 (if available)
    TreeFam Gene Tree for CD109 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD109 gene
    A2M2  C52  C32  C4B2  A2ML12  C4A2  PZP2  CPAMD82  

    CD109 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3
    Polymorphism: The Gov(b) variant in position 703 defines the Gov alloantigenic determinants


    10/2890 SNPs in CD109 are shown (see all 2890)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362364
    A colorectal cancer sample4--see VAR_0362362 Q E mis40--------
    VAR_0362374
    A colorectal cancer sample4--see VAR_0362372 N K mis40--------
    rs360138501,2
    C--74404801(+) CATAG-/CTTTGT 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs58773781,2
    C--74405264(+) TCTTC-/TTTTTT 3 -- us2k1 trp30--------
    rs346837641,2
    C--74409976(+) TAAAA-/TTTTTT 3 -- int10--------
    rs1995759371,2
    C--74421264(+) TTTTTA/TTTTTT 3 -- int10--------
    rs30458551,2
    C--74421932(-) TTTTT-/TTT   
       
    /TTTT
    GAGAC
    6 -- int1 cds12NA CSA 4
    rs38467541,2
    F--74433011(-) AAAAAA/GGAAAC 3 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.03WA 118
    rs1879688081,2
    --74433052(+) TGAGAC/TGGAGT 3 -- us2k10--------
    rs1927743401,2
    --74433080(+) GGCTGC/GAGAGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD109 (74405508 - 74538041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CD109 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2499472CNV Deletion19546169
    esv2732297CNV Deletion23290073
    esv2379909CNV Deletion18987734
    esv1316113CNV Deletion17803354
    esv274437CNV Insertion20981092
    esv268307CNV Insertion20981092
    nsv348528CNV Loss16902084
    nsv528148CNV Loss19592680
    nsv527906CNV Loss19592680
    esv9431CNV Loss19470904


    Human Gene Mutation Database (HGMD): CD109
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD109
    DNA2.0 Custom Variant and Variant Library Synthesis for CD109

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608859    OMIM disorders: --

    12 diseases for CD109:    About MalaCards
    lung squamous cell carcinoma    purpura    endotheliitis    psoriasis
    acute myeloid leukemia    myeloid leukemia    squamous cell carcinoma    rheumatoid arthritis
    arthritis    hepatocellular carcinoma    leukemia    prostatitis


    CD109 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CD109 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 33.7 13 17922683 (4), 15826242 (3), 15116102 (3)
    adenocarcinoma 31.5 3 17922683 (1), 15116102 (1)

    Genetic Association Database (GAD): CD109
    Human Genome Epidemiology (HuGE) Navigator: CD109 (7 documents)

    Export disorders for CD109 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD109 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CD109)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. (PubMed id 11861285)1, 2, 3, 9 Schuh A.C.... Ouwehand W.H. (2002)
    2. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. (PubMed id 11861284)1, 2, 3 Lin M.... Schuh A.C. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Human platelet antigen polymorphisms (HPA-1, -2, -3, -4, -5 and -15) in major ethnic groups of Pakistan. (PubMed id 19948007)1, 4 Bhatti F.A....Bugert P. (2010)
    5. Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (2009)
    6. Simultaneous genotyping of human platelet antigen-1 t o 17w by polymerase chain reaction sequence-based typing. (PubMed id 19570064)1, 4 Xu X....Yan L. (2009)
    7. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    8. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)1, 2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. (PubMed id 16754747)1, 2 Finnson K.W.... Philip A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135228 HGNC: 21685 AceView: CD109.1 Ensembl:ENSG00000156535 euGenes: HUgn135228
    ECgene: CD109 H-InvDB: CD109

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD109 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD109 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD109 gene:
    Search GeneIP for patents involving CD109

    GeneCards and IP:
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