CD109 Gene

Aliases
for CD109 gene

Previous GC identifers: GC06P074364 GC06P074401 GC06P071605

Summaries
for CD109 gene

Genomic Views
for CD109 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007299.13  

SwitchGear Promoter luciferase reporter plasmid: CD109 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD109

CD109 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P074462:  view genomic region     (about GC identifiers)

Proteins
for CD109 gene

Explore the universe of human proteins at neXtProt for CD109: NX_Q6YHK3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD109
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CD109
	GenScript Custom Purified and Recombinant Proteins Services for CD109
	Novus Biologicals CD109 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD109

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD109
	Browse OriGene Antibodies OriGene Custom Antibody Services for CD109
	GenScript Custom Superior Antibodies Services for CD109
	Novus Biologicals CD109 Antibodies
	Search for Antibodies for CD109 at Abcam
	Uscn Antibodies for CD109
	ThermoFisher Antibodies for CD109

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD109
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD109

Protein Domains /
Families
for CD109 gene

ProtoNet protein and cluster: Q6YHK3

Function
for CD109 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CD109 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD109
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CD109 (see all 26):
		hsa-miR-495 hsa-miR-3607-5p hsa-miR-875-3p hsa-miR-185* hsa-miR-340 hsa-miR-421 hsa-miR-570 hsa-miR-3154
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD109 (see all 7) OriGene shRNA RFP: CD109 OriGene siRNA: CD109
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD109

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD109

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD109 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD109 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CD109 (NM_133493)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD109
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD109

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD109
		Search LifeMap BioReagents cell lines for CD109

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD109

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cd109)

Pathways & Interactions
for CD109 gene

Drugs & Compounds
for CD109 gene

Transcripts
for CD109 gene

Expression
for CD109 gene

CD109 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTATTAAT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierPostnatal Endothelial Cells			Blood Brain Barrier, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD109 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD109
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD109
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD109

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD109

Orthologs
for CD109 gene

Paralogs
for CD109 gene

Paralogs for CD109 gene

C5²  A2ML1²  C4B²  C4A²  CPAMD8²  A2M²  C3²  PZP²  

CD109 for paralogs           About GeneDecksing

Genomic Variants
for CD109 gene

10/2520 NCBI SNPs in CD109 are shown (see all 2520)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs38467541,2	F,	--	74403589(-)	AAAAAA/GGAAAC	3	--	us2k1 tfbs3 trp3		1		WA	118
rs342399841,2	C	--	74403615(+)	TTTTT-/TGAGAC	3	--	us2k1		0	--	--	--	--
rs1879688081,2		--	74403630(+)	TGAGAC/TGGAGT	3	--	us2k1		0	--	--	--	--
rs1927743401,2		--	74403658(+)	GGCTGC/GAGAGC	3	--	us2k1		0	--	--	--	--
rs1496096651,2		--	74403677(+)	GATCTC/TGGCTC	3	--	us2k1		0	--	--	--	--
rs1842641411,2		--	74403742(+)	TAGCTC/TGGATT	3	--	us2k1		0	--	--	--	--
rs1468469421,2		--	74403890(+)	TACAGA/GTGTGA	3	--	us2k1		0	--	--	--	--
rs1379768751,2		--	74403913(+)	GGCCTC/TATTTT	3	--	us2k1		0	--	--	--	--
rs1881496601,2		--	74403940(+)	AAAATC/GCCACT	3	--	us2k1		0	--	--	--	--
rs1925818451,2		--	74404025(+)	AGCCTC/TATCTC	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD109 (74405508 - 74538041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CD109
     2 CNVs: 69558 99588
     5 Indels: 28366 40882 47157 62533 12849
Human Gene Mutation Database (HGMD): CD109

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD109

DNA2.0 Custom Variant and Variant Library Synthesis for CD109

Disorders / Diseases
for CD109 gene

12 diseases for CD109

2 Novoseek disease relationships for CD109 gene    About this table

Publications
for CD109 gene

PubMed articles for CD109 gene, integrated from 9 sources (see all 45): (articles sorted by number of sources associating them with CD109)

Utopia: connect your pdf to the dynamic world of online information

1. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. (PubMed id 11861285)^{1, 2, 3, 9} Schuh A.C.... Ouwehand W.H. (2002)
2. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. (PubMed id 11861284)^{1, 2, 3} Lin M.... Schuh A.C. (2002)
3. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (2006)
4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)^{1, 2} Sjoeblom T.... Velculescu V.E. (2006)
5. Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. (PubMed id 16754747)^{1, 2} Finnson K.W.... Philip A. (2006)
6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
7. Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians. (PubMed id 15569238)^{1, 4} Cardone J.D....Bordin J.O. (2004)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
9. CD109 represents a novel branch of the alpha2- macroglobulin/complement gene family. (PubMed id 14980714)^{1, 2} Solomon K.R.... Finberg R.W. (2004)
10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)

External Searches for CD109 gene

Genome Databases showing CD109 gene

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Specialized Databases showing CD109 gene

Products
for CD109 gene