Aliases for CD101 Gene
External Ids for CD101 Gene
Previous HGNC Symbols for CD101 Gene
Previous GeneCards Identifiers for CD101 Gene
GeneCards Summary for CD101 Gene
CD101 (CD101 Molecule) is a Protein Coding gene. Diseases associated with CD101 include Histiocytosis. Among its related pathways are TCR signaling (REACTOME) and Innate Immune System. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF3.
UniProtKB/Swiss-Prot for CD101 Gene
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.