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Aliases for CD101 Gene

Aliases for CD101 Gene

  • CD101 Molecule 2 3 5
  • Glu-Trp-Ile EWI Motif-Containing Protein 101 3 4
  • Cell Surface Glycoprotein V7 3 4
  • EWI-101 3 4
  • IGSF2 3 4
  • V7 3 4
  • Immunoglobulin Superfamily, Member 2 2
  • Immunoglobulin Superfamily Member 2 3
  • Leukocyte Surface Protein 3
  • CD101 Antigen 4
  • EWI101 4

External Ids for CD101 Gene

Previous HGNC Symbols for CD101 Gene

  • IGSF2

Previous GeneCards Identifiers for CD101 Gene

  • GC01P117345
  • GC01P117545
  • GC01P115403

Summaries for CD101 Gene

GeneCards Summary for CD101 Gene

CD101 (CD101 Molecule) is a Protein Coding gene. Diseases associated with CD101 include Histiocytosis. Among its related pathways are TCR signaling (REACTOME) and Innate Immune System. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF3.

UniProtKB/Swiss-Prot for CD101 Gene

  • Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

Gene Wiki entry for CD101 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD101 Gene

Genomics for CD101 Gene

Regulatory Elements for CD101 Gene

Enhancers for CD101 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G116986 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -12.5 -12505 5.7 HDAC1 RAD21 YY1 GATA2 ZSCAN5C FOS CEBPB REST SMARCA4 IKZF1 CD101 PTGFRN CD58 RNA5SP55
GH01G117000 1.4 Ensembl ENCODE dbSUPER 15.8 +0.7 672 4.4 ELF3 PKNOX1 ATF1 RAD21 YY1 RARA SCRT2 ETV6 IKZF2 CREM CD101 PTGFRN PIR49222
GH01G116877 1.7 FANTOM5 Ensembl ENCODE 10.3 -123.0 -123043 3.1 HDGF PKNOX1 ARNT YBX1 FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ATP1A1-AS1 MAN1A2 PTGFRN CD2 CD101 TTF2 LOC105378927 FTH1P22
GH01G116803 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -194.6 -194594 7.5 HDAC1 CBX3 ATF1 ARNT FEZF1 ZNF335 TCF12 GATA2 EGR1 ZNF143 CD2 CD101 FTH1P22 LOC105378927
GH01G116885 0.9 Ensembl ENCODE 18.4 -115.0 -114997 1.7 ZNF362 ZBTB21 JUN ZNF518A ATF2 ZFHX2 PBX2 ZNF341 ZNF629 SCRT2 CD101 PTGFRN CD2 C1orf137 LOC105378927 ENSG00000272715
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD101 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD101 Gene

Chromosome:
1
Start:
117,001,750 bp from pter
End:
117,036,551 bp from pter
Size:
34,802 bases
Orientation:
Plus strand

Genomic View for CD101 Gene

Genes around CD101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD101 Gene

Proteins for CD101 Gene

  • Protein details for CD101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93033-IGSF2_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 2
    Protein Accession:
    Q93033
    Secondary Accessions:
    • Q15856

    Protein attributes for CD101 Gene

    Size:
    1021 amino acids
    Molecular mass:
    115109 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD101 Gene

Post-translational modifications for CD101 Gene

  • N-glycosylated.
  • Glycosylation at posLast=4444, posLast=322322, posLast=598598, Asn721, posLast=788788, and Asn823
  • Modification sites at PhosphoSitePlus

Other Protein References for CD101 Gene

No data available for DME Specific Peptides for CD101 Gene

Domains & Families for CD101 Gene

Protein Domains for CD101 Gene

Suggested Antigen Peptide Sequences for CD101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD101: view

No data available for UniProtKB/Swiss-Prot for CD101 Gene

Function for CD101 Gene

Molecular function for CD101 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

Gene Ontology (GO) - Molecular Function for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA --
genes like me logo Genes that share ontologies with CD101: view

Phenotypes for CD101 Gene

genes like me logo Genes that share phenotypes with CD101: view

Animal Models for CD101 Gene

MGI Knock Outs for CD101:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD101 Gene

Localization for CD101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD101 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD101 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7722300
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CD101: view

Pathways & Interactions for CD101 Gene

genes like me logo Genes that share pathways with CD101: view

Pathways by source for CD101 Gene

Interacting Proteins for CD101 Gene

Gene Ontology (GO) - Biological Process for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002763 positive regulation of myeloid leukocyte differentiation IEA --
GO:0007166 cell surface receptor signaling pathway TAS 7722300
genes like me logo Genes that share ontologies with CD101: view

No data available for SIGNOR curated interactions for CD101 Gene

Drugs & Compounds for CD101 Gene

(1) Drugs for CD101 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CD101: view

Transcripts for CD101 Gene

mRNA/cDNA for CD101 Gene

Unigene Clusters for CD101 Gene

CD101 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD101 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2:

Relevant External Links for CD101 Gene

GeneLoc Exon Structure for
CD101
ECgene alternative splicing isoforms for
CD101

Expression for CD101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD101 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for CD101 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Lymph node (15.2), Pancreatic juice (7.7), CD8 Tcells (7.1), and Monocytes (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD101 Gene



Protein tissue co-expression partners for CD101 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD101 Gene:

CD101

SOURCE GeneReport for Unigene cluster for CD101 Gene:

Hs.654598

mRNA Expression by UniProt/SwissProt for CD101 Gene:

Q93033-IGSF2_HUMAN
Tissue specificity: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
genes like me logo Genes that share expression patterns with CD101: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD101 Gene

Orthologs for CD101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD101 34 35
  • 98.92 (n)
cow
(Bos Taurus)
Mammalia CD101 34 35
  • 83.1 (n)
dog
(Canis familiaris)
Mammalia CD101 34 35
  • 83.02 (n)
mouse
(Mus musculus)
Mammalia Cd101 34 16 35
  • 79.4 (n)
rat
(Rattus norvegicus)
Mammalia Cd101 34
  • 78.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CD101 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD101 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD101 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD101 35
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:91849 35
  • 29 (a)
ManyToMany
CABZ01067072.1 35
  • 21 (a)
ManyToMany
Species where no ortholog for CD101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD101 Gene

ENSEMBL:
Gene Tree for CD101 (if available)
TreeFam:
Gene Tree for CD101 (if available)

Paralogs for CD101 Gene

Paralogs for CD101 Gene

(2) SIMAP similar genes for CD101 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD101 Gene

genes like me logo Genes that share paralogs with CD101: view

Variants for CD101 Gene

Sequence variations from dbSNP and Humsavar for CD101 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000015200 -- 117,025,192(+) ACCCC(A/G)TCTCT intron-variant, downstream-variant-500B
rs1000148756 -- 116,997,577(+) ACATG(A/G)CAGAT intron-variant
rs1000267198 -- 117,000,294(+) TCTTC(C/T)GTTCC intron-variant, upstream-variant-2KB
rs1000295135 -- 116,993,085(+) GTGGG(G/T)TGAGG intron-variant
rs1000487954 -- 117,037,624(+) GATGA(C/T)TAAGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD101 Gene

Variant ID Type Subtype PubMed ID
nsv517575 CNV loss 19592680
nsv831159 CNV loss 17160897

Variation tolerance for CD101 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD101 Gene

Human Gene Mutation Database (HGMD)
CD101
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD101 Gene

Disorders for CD101 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD101 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
histiocytosis
  • chronic histiocytosis x
- elite association - COSMIC cancer census association via MalaCards
Search CD101 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD101

Human Genome Epidemiology (HuGE) Navigator
CD101
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD101
genes like me logo Genes that share disorders with CD101: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD101 Gene

Publications for CD101 Gene

  1. V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene. (PMID: 7722300) Ruegg C.L. … Engleman E.G. (J. Immunol. 1995) 2 3 4 64
  2. CD4+ CD56+ blastic tumor cells express CD101 molecules. (PMID: 15737213) Meyer N. … Bagot M. (J. Invest. Dermatol. 2005) 3 4 64
  3. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PMID: 11504738) Stipp C.S. … Hemler M.E. (J. Biol. Chem. 2001) 3 4 64
  4. CD101 expression by Langerhans cell histiocytosis cells. (PMID: 10692025) Bouloc A. … Bagot M. (Histopathology 2000) 3 4 64
  5. Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production. (PMID: 11093127) Bouloc A. … Boumsell L. (Eur. J. Immunol. 2000) 3 4 64

Products for CD101 Gene

Sources for CD101 Gene

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