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CD101 Gene

protein-coding   GIFtS: 55
GCID: GC01P117545

CD101 Molecule

(Previous names: immunoglobulin superfamily, member 2)
(Previous symbol: IGSF2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD101 Molecule1 2     Immunoglobulin Superfamily, Member 21
IGSF21 2 3     Immunoglobulin Superfamily Member 22
Cell Surface Glycoprotein V72 3     Leukocyte Surface Protein2
Glu-Trp-Ile EWI Motif-Containing Protein 1012 3     EWI1013
EWI-1012 3     IgSF23
V72 3     CD101 Antigen3

External Ids:    HGNC: 59491   Entrez Gene: 93982   Ensembl: ENSG000001342567   OMIM: 6045165   UniProtKB: Q930333   

Export aliases for CD101 gene to outside databases

Previous GC identifers: GC01P117345 GC01P115403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD101 Gene:
CD101 (CD101 molecule) is a protein-coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF8.

UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033
Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on
activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and
cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes
in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the
nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells.
May be a marker of CD4(+) CD56(+) leukemic tumor cells

Gene Wiki entry for CD101 (IGSF2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CD101
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD101 promoter sequence
   Search Chromatin IP Primers for CD101

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD101


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

CD101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD101 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117545:  view genomic region     (about GC identifiers)

Start:
117,544,382 bp from pter      End:
117,579,167 bp from pter
Size:
34,786 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 2 precursor  
Size: 1021 amino acids; 115109 Da
Secondary accessions: Q15856

Explore the universe of human proteins at neXtProt for CD101: NX_Q93033

Explore proteomics data for CD101 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn44, Asn322, Asn598, Asn721, Asn788, Asn823
  • Modification sites at PhosphoSitePlus

  • See CD101 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243035.1  NP_001243038.1  NP_001243040.1  NP_004249.2  

    ENSEMBL proteins: 
     ENSP00000358482   ENSP00000256652  

    CD101 Human Recombinant Protein Products:

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    Novus Biologicals CD101 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD101 

     
    antibodies-online proteins for CD101 (2 products) 

     
    Search antibodies-online for peptides for CD101

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    antibodies-online antibodies for CD101 (61 products) 

    CD101 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD101 
    antibodies-online kits for CD101 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR013098 Ig_I-set
     IPR002195 Dihydroorotase_CS
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q93033

    ProtoNet protein and cluster: Q93033

    1 Blocks protein domain: IPB002195 Dihydroorotase

    UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with CD101           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGSF2_HUMAN, Q93033
    Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on
    activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and
    cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes
    in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the
    nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells.
    May be a marker of CD4(+) CD56(+) leukemic tumor cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--
         
    Find genes that share ontologies with CD101           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD101:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd101):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD101           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd101tm1.1Dil for CD101

       genOway: Develop your customized and physiologically relevant rodent model for CD101

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD101:
    hsa-mir-335-5p (MIRT019170)

    Block miRNA regulation of human, mouse, rat CD101 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCD101 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD101

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CD101 (NM_004258)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD101

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD101


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGSF2_HUMAN, Q93033: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS7722300
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with CD101           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD101
    Interactions:

        Search GeneGlobe Interaction Network for CD101

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CD101 (Q930332, 3 ENSP000002566524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999632, 3MINT-65088 I2D: score=5 
    PUF60Q9UHX12, 3MINT-65089 I2D: score=4 
    SRSF5Q132432, 3, ENSP000003778924MINT-65087 I2D: score=5 STRING: ENSP00000377892
    ST13P505022, 3, ENSP000002162184MINT-65086 I2D: score=5 STRING: ENSP00000216218
    IGSF3ENSP000003211844STRING: ENSP00000321184
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7722300

    Find genes that share ontologies with CD101           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD101 (IGSF2)

    1 HMDB Compound for CD101    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD101 gene (4 alternative transcripts): 
    NM_001256106.2  NM_001256109.2  NM_001256111.2  NM_004258.5  

    Unigene Cluster for CD101:

    CD101 molecule
    Hs.654598  [show with all ESTs]
    Unigene Representative Sequence: NM_004258
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369470 ENST00000467588 ENST00000460180 ENST00000256652(uc010oxb.1 uc009whd.3 uc010oxc.1 uc010oxd.1)

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CD101
    SwitchGear 3'UTR luciferase reporter plasmidCD101 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD101
    Predesigned siRNA for gene silencing in human, mouse, rat CD101
    Clone
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    OriGene clones in human, mouse for CD101 (see all 7)
    OriGene ORF clones in mouse, rat for CD101
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD101 (NM_004258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD101
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD101
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD101
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD101
      QuantiTect SYBR Green Assays in human, mouse, rat CD101
      QuantiFast Probe-based Assays in human, mouse, rat CD101

    Additional mRNA sequence: 

    AK298237.1 AK307542.1 BC130327.1 BC136484.1 BC171768.1 Z33642.1 

    3 DOTS entries:

    DT.100669655  DT.200957  DT.95153918 

    11 AceView cDNA sequences:

    NM_004258 Z33642 BE746215 BG504603 BX283362 AI698289 AI791963 AI732666 
    BM069664 AA594805 BG980559 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD101    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                  -           -               
    SP2:                                                                              


    ECgene alternative splicing isoforms for CD101

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD101 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCAATGCA
    CD101 Expression
    About this image


    CD101 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CD101 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD101 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654598

    UniProtKB/Swiss-Prot: IGSF2_HUMAN, Q93033
    Tissue specificity: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells,
    activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology.
    Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH
    (Langerhans cell histiocytosis) patients

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD101

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD101 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd1011 , 5 CD101 antigen1, 5 79.4(n)1
    71.78(a)1
      3 (43.90 cM)5
    6301461  NM_001167906.11  NP_001161378.11 
     1009935305 
    chicken
    (Gallus gallus)
    Aves CD1016
    CD101 molecule
    37(a)
    1 ↔ 1
    1(91431223-91441019)
    lizard
    (Anolis carolinensis)
    Reptilia CD1016
    CD101 molecule
    39(a)
    1 ↔ 1
    3(162933901-162943108)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:918496
    CABZ01067072.16
    Uncharacterized protein
    29(a)
    21(a)
    many ↔ many
    many ↔ many
    9(27602-39587) ENSDARG00000014323
    9(520131-534160) ENSDARG00000086721


    ENSEMBL Gene Tree for CD101 (if available)
    TreeFam Gene Tree for CD101 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD101 gene
    IGSF82  IGSF32  PTGFRN2  
    2 SIMAP similar genes for CD101 using alignment to 1 protein entry:     IGSF2_HUMAN:
    IGSF3    IGSF8

    Find genes that share paralogs with CD101           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CD101
    PGOHUM00000244866


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD101 (see all 906)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600728451,2
    C,F--117542459(+) TACCAA/GTTTTC 4 -- us2k13Minor allele frequency- G:0.22WA CSA 122
    rs1810576531,2
    --117542557(+) CTAGCA/GTAGTA 4 -- us2k10--------
    rs802886991,2
    F--117542571(+) GTCTAG/TGTTCA 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs730041051,2
    C,F--117542666(+) CCAACA/GGGTTT 4 -- us2k13Minor allele frequency- G:0.23WA CSA 122
    rs730041061,2
    C,F--117542701(+) ACAGAC/TTTATC 4 -- us2k13Minor allele frequency- T:0.23WA CSA 122
    rs75372571,2
    C,F--117542751(+) acagaA/Gccagc 4 -- us2k15Minor allele frequency- G:0.07NA WA 244
    rs1478290621,2
    --117542799(+) TCCCCG/TGAAAT 4 -- us2k10--------
    rs1416130761,2
    --117542833(+) TAATTC/TGGCAG 4 -- us2k10--------
    rs1470647421,2
    --117542842(+) AGGCCA/CGGGAG 4 -- us2k10--------
    rs1451469701,2
    C--117542928(+) AAGTGA/GGATCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD101 (117544382 - 117579167 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD101:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517575CNV Loss19592680
    nsv831159CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD101
    DNA2.0 Custom Variant and Variant Library Synthesis for CD101

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604516    OMIM disorders: --


    Find genes that share disorders with CD101           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CD101 (1 document)

    Export disorders for CD101 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD101 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CD101)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene. (PubMed id 7722300)1, 2, 3 Ruegg C.L.... Engleman E.G. (J. Immunol. 1995)
    2. CD4+ CD56+ blastic tumor cells express CD101 molecules. (PubMed id 15737213)1, 2 Meyer N.... Bagot M. (J. Invest. Dermatol. 2005)
    3. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)1, 2 Stipp C.S.... Hemler M.E. (J. Biol. Chem. 2001)
    4. CD101 expression by Langerhans cell histiocytosis cells. (PubMed id 10692025)1, 2 Bouloc A....Bagot M. (Histopathology 2000)
    5. Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production. (PubMed id 11093127)1, 2 Bouloc A.... Boumsell L. (Eur. J. Immunol. 2000)
    6. V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation. (PubMed id 9647226)1, 2 Soares L.R.B.... Engleman E.G. (J. Immunol. 1998)
    7. Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism. (PubMed id 9233604)1, 2 Soares L.R.B.... Engleman E.G. (J. Immunol. 1997)
    8. CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. (PubMed id 9389317)1, 2 Bagot M.... Boumsell L. (Tissue Antigens 1997)
    9. V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies. (PubMed id 7722299)1, 2 Rivas A....Engleman E.G. (J. Immunol. 1995)
    10. Inflammation-related gene variants as risk factors for pancreatic cancer. (PubMed id 21467233)1 Reid-Lombardo K.M....Petersen G.M. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9398 HGNC: 5949 AceView: IGSF2 Ensembl:ENSG00000134256 euGenes: HUgn9398
    ECgene: CD101 H-InvDB: CD101

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD101 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CD101 gene:
    Search GeneIP for patents involving CD101

    GeneCards and IP:
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