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Aliases for CD101 Gene

Aliases for CD101 Gene

  • CD101 Molecule 2 3
  • Glu-Trp-Ile EWI Motif-Containing Protein 101 3 4
  • Cell Surface Glycoprotein V7 3 4
  • EWI-101 3 4
  • IGSF2 3 4
  • V7 3 4
  • Immunoglobulin Superfamily, Member 2 2
  • Immunoglobulin Superfamily Member 2 3
  • Leukocyte Surface Protein 3
  • CD101 Antigen 4
  • EWI101 4

External Ids for CD101 Gene

Previous Symbols for CD101 Gene

  • IGSF2

Summaries for CD101 Gene

GeneCards Summary for CD101 Gene

CD101 (CD101 Molecule) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is PTGFRN.

UniProtKB/Swiss-Prot for CD101 Gene

  • Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

Gene Wiki entry for CD101 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD101 Gene

Genomics for CD101 Gene

Genomic Location for CD101 Gene

Start:
117,001,750 bp from pter
End:
117,036,551 bp from pter
Size:
34,802 bases
Orientation:
Plus strand

Genomic View for CD101 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD101 Gene

No data available for Regulatory Elements for CD101 Gene

Proteins for CD101 Gene

  • Protein details for CD101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93033-IGSF2_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 2
    Protein Accession:
    Q93033
    Secondary Accessions:
    • Q15856

    Protein attributes for CD101 Gene

    Size:
    1021 amino acids
    Molecular mass:
    115109 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD101 Gene

Proteomics data for CD101 Gene at MOPED

Post-translational modifications for CD101 Gene

Other Protein References for CD101 Gene

No data available for DME Specific Peptides for CD101 Gene

Domains for CD101 Gene

Gene Families for CD101 Gene

HGNC:
  • CD :CD molecules
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD101 Gene

Suggested Antigen Peptide Sequences for CD101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93033

UniProtKB/Swiss-Prot:

IGSF2_HUMAN
Domain:
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q93033
genes like me logo Genes that share domains with CD101: view

Function for CD101 Gene

Molecular function for CD101 Gene

UniProtKB/Swiss-Prot Function: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

Gene Ontology (GO) - Molecular Function for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA --
genes like me logo Genes that share ontologies with CD101: view

Phenotypes for CD101 Gene

MGI mutant phenotypes for CD101:
inferred from 1 alleles
GenomeRNAi human phenotypes for CD101:
genes like me logo Genes that share phenotypes with CD101: view

Animal Models for CD101 Gene

MGI Knock Outs for CD101:

miRNA for CD101 Gene

miRTarBase miRNAs that target CD101

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD101 Gene

Localization for CD101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD101 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD101 Gene COMPARTMENTS Subcellular localization image for CD101 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7722300
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CD101: view

Pathways for CD101 Gene

SuperPathways for CD101 Gene

No Data Available

Interacting Proteins for CD101 Gene

Gene Ontology (GO) - Biological Process for CD101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002763 positive regulation of myeloid leukocyte differentiation IEA --
GO:0007166 cell surface receptor signaling pathway TAS 7722300
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CD101: view

No data available for Pathways by source for CD101 Gene

Compounds for CD101 Gene

(1) HMDB Compounds for CD101 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CD101: view

Transcripts for CD101 Gene

mRNA/cDNA for CD101 Gene

Unigene Clusters for CD101 Gene

CD101 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD101 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2:

Relevant External Links for CD101 Gene

GeneLoc Exon Structure for
CD101
ECgene alternative splicing isoforms for
CD101

Expression for CD101 Gene

mRNA expression in normal human tissues for CD101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD101 Gene

This gene is overexpressed in Whole Blood (8.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD101 Gene

SOURCE GeneReport for Unigene cluster for CD101 Gene Hs.654598

mRNA Expression by UniProt/SwissProt for CD101 Gene

Q93033-IGSF2_HUMAN
Tissue specificity: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
genes like me logo Genes that share expressions with CD101: view

Orthologs for CD101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD101 35
  • 98.92 (n)
  • 98.14 (a)
CD101 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD101 35
  • 83.1 (n)
  • 75.74 (a)
CD101 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD101 35
  • 83.02 (n)
  • 76.95 (a)
CD101 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd101 35
  • 79.4 (n)
  • 71.78 (a)
Cd101 16
Cd101 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD101 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD101 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd101 35
  • 78.87 (n)
  • 71.5 (a)
chicken
(Gallus gallus)
Aves CD101 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD101 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01067072.1 36
  • 21 (a)
ManyToMany
zgc:91849 36
  • 29 (a)
ManyToMany
Species with no ortholog for CD101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD101 Gene

ENSEMBL:
Gene Tree for CD101 (if available)
TreeFam:
Gene Tree for CD101 (if available)

Paralogs for CD101 Gene

Paralogs for CD101 Gene

Selected SIMAP similar genes for CD101 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD101 Gene

genes like me logo Genes that share paralogs with CD101: view

Variants for CD101 Gene

Sequence variations from dbSNP and Humsavar for CD101 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs755854 -- 117,020,960(+) TGGGG(C/T)CAAAG intron-variant
rs1009262 -- 117,012,390(+) gtgag(A/C)gtggg intron-variant
rs1010767 -- 117,014,963(-) GATGC(A/G)TAAAG intron-variant
rs1157683 -- 117,002,700(+) ataaa(A/T)tataa intron-variant
rs1555793 -- 117,014,609(+) TATCT(A/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD101 Gene

Variant ID Type Subtype PubMed ID
nsv831159 CNV Loss 17160897
nsv517575 CNV Loss 19592680

Relevant External Links for CD101 Gene

HapMap Linkage Disequilibrium report
CD101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD101 Gene

Disorders for CD101 Gene

Relevant External Links for CD101

Human Genome Epidemiology (HuGE) Navigator
CD101
genes like me logo Genes that share disorders with CD101: view

No data available for UniProtKB/Swiss-Prot for CD101 Gene

Publications for CD101 Gene

  1. V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene. (PMID: 7722300) Ruegg C.L. … Engleman E.G. (J. Immunol. 1995) 2 3 4
  2. Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism. (PMID: 9233604) Soares L.R.B. … Engleman E.G. (J. Immunol. 1997) 3 4
  3. CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. (PMID: 9389317) Bagot M. … Boumsell L. (Tissue Antigens 1997) 3 4
  4. V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation. (PMID: 9647226) Soares L.R.B. … Engleman E.G. (J. Immunol. 1998) 3 4
  5. CD101 expression by Langerhans cell histiocytosis cells. (PMID: 10692025) Bouloc A. … Bagot M. (Histopathology 2000) 3 4

Products for CD101 Gene

Sources for CD101 Gene

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