CCZ1B Gene
protein-coding GIFtS: 38
GCID: GC07M006836
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CCZ1 vacuolar protein trafficking and biogenesis associated...(Previous name: chromosome 7 open reading frame 28B )
(Previous symbol: C7orf28B)
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Aliases
for CCZ1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B (S.Cerevisiae)1 2 | | Chromosome 7 Open Reading Frame 28B1 | | C7orf28B1 2 3 | | H_DJ1163J12.22 | | H_NH0577018.21 2 | | Vacuolar Fusion Protein CCZ1 Homolog B2 | | DKFZP586I10231 | | Vacuolar Fusion Protein CCZ1 Homolog-Like3 | | MGC198191 | | |
Export aliases for CCZ1B gene to outside databases |
Summaries
for CCZ1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCZ1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CCZ1B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCZ1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCZ1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.2CCZ1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M006836: view genomic region
(about GC identifiers)
Start:
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6,836,440 bp from pter |
End:
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6,866,401 bp from pter |
Size:
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29,962 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 6,885,604-6,912,964 |
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Proteins
for CCZ1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCZ1B_HUMAN, P86790 (See
protein sequence)Recommended Name: Vacuolar fusion protein CCZ1 homolog B Size: 482 amino acids; 55866 Da
Subcellular location: Lysosome membrane
Secondary accessions: A2RU45 O95766 Q9UG65 Q9Y359Explore the universe of human proteins at neXtProt for CCZ1B: NX_P86790
CCZ1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_932765.1
ENSEMBL proteins: ENSP00000314544 ENSP00000390078 ENSP00000444720
Human Recombinant Protein Products for CCZ1B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005765 | lysosomal membrane |
IEA | -- |
CCZ1B for ontologies About GeneDecksing
CCZ1B Antibody Products:
Assay Products for CCZ1B: |
Protein
Domains /
Families
for CCZ1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCZ1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P86790ProtoNet protein and cluster: P86790 UniProtKB/Swiss-Prot: CCZ1B_HUMAN, P86790Similarity: Belongs to the CCZ1 family |
Function
for CCZ1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for CCZ1B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CCZ1B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCZ1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCZ1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1B |
|
Pathways & Interactions
for CCZ1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCZ1B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for CCZ1B (P867903 ENSP000003145444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCZ1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCZ1B
Search CenterWatch for drugs/clinical trials and news about CCZ1B
|
Transcripts
for CCZ1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCZ1B gene: NM_198097.3 Unigene Cluster for CCZ1B: CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) Hs.567779 [show with all ESTs]Unigene Representative Sequence: BC10830213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481830 ENST00000472464 ENST00000316731(uc003sqx.2 uc011jxd.2)
ENST00000467004 ENST00000468078 ENST00000462378 ENST00000485620 ENST00000411858
ENST00000490178 ENST00000496187 ENST00000464543(uc003sqy.2) ENST00000486840
ENST00000538180
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CCZ1B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCZ1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCZ1B |
Additional cDNA sequence: AK000993.1 AK292326.1 AK296026.1 AL050215.1 BC010130.2 BC108302.1 12 DOTS entries: DT.100890363 DT.97856263 DT.92072227 DT.75159455 DT.95258711 DT.121095986 DT.121096001 DT.121128033 DT.121128037 DT.121128051 DT.92072238 DT.95258690 24/300 AceView cDNA sequences (see all 300): AI208759 AI309982 AA379841 BQ889481 BQ028327 AL554597 CR590431 BG113949 BQ938093 CR595861 BU684846 BM992989 AA835425 AA811971 BQ063050 BE874607 BM761646 BG177605 BP341272 CR597206 BM826046 AJ713879 BE294404 AW189559
GeneLoc Exon Structure
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Expression
for CCZ1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCZ1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CCZ1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCZ1B
SOURCE GeneReport for Unigene cluster: Hs.567779
SABiosciences Custom PCR Arrays for CCZ1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCZ1B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CCZ1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCZ1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCZ1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1B |
Orthologs
for CCZ1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCZ1B gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for CCZ1B (if available)
TreeFam Gene Tree for CCZ1B (if available) |
Paralogs
for CCZ1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCZ1B gene
- CCZ11 2
2 SIMAP similar genes for CCZ1B using alignment to 3 protein entries: CCZ1B_HUMAN (see all proteins):CCZ1 DKFZp586I1023
CCZ1B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CCZ1B
PGOHUM00000245992 PGOHUM00000232926
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Genomic Variants
for CCZ1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCZ1B (6836440 - 6866401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCZ1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCZ1B |
|
Disorders
/ Diseases
for CCZ1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCZ1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCZ1B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CCZ1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Integral and associated lysosomal membrane proteins. (PubMed id 17897319)2 Schroeder B.... Hasilik A. (2007)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for CCZ1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CCZ1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCZ1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCZ1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCZ1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCZ1B gene:
Search GeneIP for patents involving CCZ1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCZ1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCZ1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCZ1B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CCZ1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCZ1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for CCZ1B |
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 | | | CCZ1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCZ1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCZ1B |
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