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CCZ1B Gene

protein-coding   GIFtS: 38
GCID: GC07M006836

CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated...

(Previous name: chromosome 7 open reading frame 28B)
(Previous symbol: C7orf28B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B
(S. Cerevisiae)1 2
     H_DJ1163J12.22
C7orf28B1 2 3     H_NH0577018.22
Chromosome 7 Open Reading Frame 28B1     Vacuolar Fusion Protein CCZ1 Homolog B2
Similar To CGI-43 Protein1     Vacuolar Fusion Protein CCZ1 Homolog-Like3

External Ids:    HGNC: 217171   Entrez Gene: 2219602   Ensembl: ENSG000001465747   UniProtKB: P867903   

Export aliases for CCZ1B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCZ1B Gene:
CCZ1B (CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is CCZ1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCZ1B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCZ1B promoter sequence
   Search Chromatin IP Primers for CCZ1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCZ1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.2

CCZ1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCZ1B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006836:  view genomic region     (about GC identifiers)

Start:
6,833,765 bp from pter      End:
6,866,401 bp from pter
Size:
32,637 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,885,604-6,912,964     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCZ1B_HUMAN, P86790 (See protein sequence)
Recommended Name: Vacuolar fusion protein CCZ1 homolog B  
Size: 482 amino acids; 55866 Da
Secondary accessions: A2RU45 O95766 Q9UG65 Q9Y359

Explore the universe of human proteins at neXtProt for CCZ1B: NX_P86790

Explore proteomics data for CCZ1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys246, Lys295, Lys365, Lys396, Lys456
  • Modification sites at PhosphoSitePlus

  • See CCZ1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_932765.1  
    ENSEMBL proteins: 
     ENSP00000314544   ENSP00000390078   ENSP00000444720  

    CCZ1B Human Recombinant Protein Products:

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    Search eBioscience for Proteins for CCZ1B 

     
    antibodies-online proteins for CCZ1B 

     
    Search antibodies-online for peptides for CCZ1B

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    antibodies-online antibodies for CCZ1B (2 products) 

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    antibodies-online kits for CCZ1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013176 DUF1712_fun

    Graphical View of Domain Structure for InterPro Entry P86790

    ProtoNet protein and cluster: P86790

    UniProtKB/Swiss-Prot: CCZ1B_HUMAN, P86790
    Similarity: Belongs to the CCZ1 family


    Find genes that share domains with CCZ1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CCZ1B:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCZ1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCZ1B:
    hsa-mir-100-5p (MIRT048533), hsa-mir-192-5p (MIRT026766), hsa-mir-215-5p (MIRT024419)

    Block miRNA regulation of human, mouse, rat CCZ1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCZ1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCZ1B

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCZ1B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCZ1B_HUMAN, P86790: Lysosome membrane

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--

    Find genes that share ontologies with CCZ1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCZ1B
    Interactions:

        Search GeneGlobe Interaction Network for CCZ1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CCZ1B (P867903 ENSP000003145444) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYCO1Q9BQS83, ENSP000002961374I2D: score=2 STRING: ENSP00000296137
    MON1AQ86VX93, ENSP000002964734I2D: score=1 STRING: ENSP00000296473
    DEDDO756183I2D: score=1 
    CDC5LENSP000003605324STRING: ENSP00000360532
    MON1BENSP000002482484STRING: ENSP00000248248
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCZ1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCZ1B gene: 
    NM_198097.3  

    Unigene Cluster for CCZ1B:

    CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
    Hs.567779  [show with all ESTs]
    Unigene Representative Sequence: BC108302
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429267 ENST00000597208 ENST00000481830 ENST00000472464 ENST00000316731(uc003sqx.2 uc011jxd.2)
    ENST00000467004 ENST00000468078 ENST00000462378 ENST00000485620 ENST00000411858
    ENST00000490178 ENST00000496187 ENST00000464543(uc003sqy.2) ENST00000486840
    ENST00000538180
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CCZ1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCZ1B
    Predesigned siRNA for gene silencing in human, mouse, rat CCZ1B
    Clone
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    GenScript Custom all cDNA clones Services for CCZ1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCZ1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCZ1B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCZ1B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CCZ1B
      QuantiTect SYBR Green Assays in human, mouse, rat CCZ1B
      QuantiFast Probe-based Assays in human, mouse, rat CCZ1B

    Additional mRNA sequence: 

    AK000993.1 AK292326.1 AK296026.1 AL050215.1 BC010130.2 BC108302.1 

    12 DOTS entries:

    DT.100890363  DT.97856263  DT.92072227  DT.75159455  DT.95258711  DT.121095986  DT.121096001  DT.121128033 
    DT.121128037  DT.121128051  DT.92072238  DT.95258690 

    Selected AceView cDNA sequences (see all 300):

    BU166735 AI077552 AA315414 AA811971 AJ713879 BG177605 BM826046 CR597206 
    BP341272 BM971014 BU680505 BM468732 AW189559 AI613432 BE294404 BM479623 
    BU684846 CK821778 AA835425 CR595861 CB118978 BE874607 BQ063050 BM992989 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCZ1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCZ1B Expression
    About this image

    CCZ1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCZ1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567779
        Custom PCR Arrays for CCZ1B
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CCZ1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCZ1B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccz11 CCZ1 vacuolar protein trafficking and biogenesis associated 89.01(n)
    96.57(a)
      231874  NM_177682.3  NP_808350.1 
    chicken
    (Gallus gallus)
    Aves CCZ11 CCZ1 vacuolar protein trafficking and biogenesis associated more 83.33(n)
    93.78(a)
      416433  NM_001006158.1  NP_001006158.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343507.1(299508-323921)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688312 hypothetical protein MGC68831 78.07(n)    BC055965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553442 hypothetical protein MGC55344 77.98(n)   393103  BC044374.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149801 CG14980 46(n)
    31.33(a)
      38455  NM_139578.3  NP_647835.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ccz-11 ccz-1 44.47(n)
    31.09(a)
      186547  NM_073986.3  NP_506387.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G809101 AT1G80910 43.1(n)
    26.74(a)
      844431  NM_106739.3  NP_178206.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04273001 Os08g0427300 39.17(n)
    25.12(a)
      4345617  NM_001068377.1  NP_001061842.1 


    ENSEMBL Gene Tree for CCZ1B (if available)
    TreeFam Gene Tree for CCZ1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCZ1B gene
    CCZ11 2  
    2 SIMAP similar genes for CCZ1B using alignment to 3 protein entries:     CCZ1B_HUMAN (see all proteins):
    CCZ1    DKFZp586I1023

    Find genes that share paralogs with CCZ1B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CCZ1B
    PGOHUM00000245992 PGOHUM00000232926


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCZ1B (see all 614)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013699251,2
    C,F--6838915(+) TCTGCA/GACAAG 1 -- int11Minor allele frequency- G:0.01EU 841
    rs2005220561,2
    C--6839274(+) CCGCCC/TACCTT 1 -- int10--------
    rs2014095691,2
    C--6839876(+) TTGGCA/GGGAAG 1 -- int10--------
    rs1855813521,2
    --6839970(+) CAAAAC/GATATG 1 -- int10--------
    rs3767678351,2
    C--6839993(+) ATATT-/AAAAAA 1 -- int10--------
    rs1434877511,2
    C--6840375(+) CTTTCG/TGCCAT 1 -- int10--------
    rs2015835521,2
    C,F--6840748(+) TCATAC/TGGCCA 1 -- int11Minor allele frequency- T:0.00EU 1159
    rs1998415951,2
    --6840968(+) GGGACA/GCCTGA 1 -- int10--------
    rs2021394821,2
    C--6841566(+) ATGTG-/CTGT  
            
    CTGTC
    1 -- int10--------
    rs1496860791,2
    --6841628(+) TATAGA/CCCGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCZ1B (6833765 - 6866401 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCZ1B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCZ1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CCZ1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCZ1B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CCZ1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221960 HGNC: 21717 AceView: C7orf28A Ensembl:ENSG00000146574 euGenes: HUgn221960
    ECgene: CCZ1B H-InvDB: CCZ1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCZ1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCZ1B gene:
    Search GeneIP for patents involving CCZ1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for CCZ1B
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