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Aliases for CCZ1B Gene

Aliases for CCZ1B Gene

  • CCZ1 Homolog B, Vacuolar Protein Trafficking And Biogenesis Associated 2 3 5
  • CCZ1 Homolog, Vacuolar Protein Trafficking And Biogenesis Associated B 2 3
  • C7orf28B 3 4
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B (S. Cerevisiae) 2
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B 3
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated B 3
  • Vacuolar Fusion Protein CCZ1 Homolog-Like 4
  • Chromosome 7 Open Reading Frame 28B 2
  • Similar To CGI-43 Protein 2
  • H_DJ1163J12.2 3
  • H_NH0577018.2 3

External Ids for CCZ1B Gene

Previous HGNC Symbols for CCZ1B Gene

  • C7orf28B

Previous GeneCards Identifiers for CCZ1B Gene

  • GC07M006836

Summaries for CCZ1B Gene

GeneCards Summary for CCZ1B Gene

CCZ1B (CCZ1 Homolog B, Vacuolar Protein Trafficking And Biogenesis Associated) is a Protein Coding gene. An important paralog of this gene is CCZ1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCZ1B Gene

Genomics for CCZ1B Gene

Regulatory Elements for CCZ1B Gene

Enhancers for CCZ1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCZ1B on UCSC Golden Path with GeneCards custom track

Promoters for CCZ1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCZ1B on UCSC Golden Path with GeneCards custom track

Genomic Location for CCZ1B Gene

Chromosome:
7
Start:
6,794,134 bp from pter
End:
6,826,770 bp from pter
Size:
32,637 bases
Orientation:
Minus strand

Genomic View for CCZ1B Gene

Genes around CCZ1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCZ1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCZ1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCZ1B Gene

Proteins for CCZ1B Gene

  • Protein details for CCZ1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86790-CCZ1B_HUMAN
    Recommended name:
    Vacuolar fusion protein CCZ1 homolog B
    Protein Accession:
    P86790
    Secondary Accessions:
    • A2RU45
    • O95766
    • Q9UG65
    • Q9Y359

    Protein attributes for CCZ1B Gene

    Size:
    482 amino acids
    Molecular mass:
    55866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCZ1B Gene

Proteomics data for CCZ1B Gene at MOPED

Post-translational modifications for CCZ1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCZ1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCZ1B Gene

Domains & Families for CCZ1B Gene

Protein Domains for CCZ1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCZ1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86790

UniProtKB/Swiss-Prot:

CCZ1B_HUMAN :
  • Belongs to the CCZ1 family.
Family:
  • Belongs to the CCZ1 family.
genes like me logo Genes that share domains with CCZ1B: view

No data available for Gene Families for CCZ1B Gene

Function for CCZ1B Gene

Phenotypes for CCZ1B Gene

genes like me logo Genes that share phenotypes with CCZ1B: view

Animal Model Products

CRISPR Products

miRNA for CCZ1B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCZ1B Gene

Localization for CCZ1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCZ1B Gene

Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCZ1B Gene COMPARTMENTS Subcellular localization image for CCZ1B gene
Compartment Confidence
lysosome 4
vacuole 4
cytosol 2
endosome 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCZ1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031988 membrane-bounded vesicle IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CCZ1B: view

Pathways & Interactions for CCZ1B Gene

SuperPathways for CCZ1B Gene

No Data Available

Interacting Proteins for CCZ1B Gene

Gene Ontology (GO) - Biological Process for CCZ1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCZ1B Gene

Drugs & Compounds for CCZ1B Gene

No Compound Related Data Available

Transcripts for CCZ1B Gene

Unigene Clusters for CCZ1B Gene

CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCZ1B Gene

No ASD Table

Relevant External Links for CCZ1B Gene

GeneLoc Exon Structure for
CCZ1B
ECgene alternative splicing isoforms for
CCZ1B

Expression for CCZ1B Gene

mRNA expression in normal human tissues for CCZ1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CCZ1B Gene Hs.567779

genes like me logo Genes that share expression patterns with CCZ1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCZ1B Gene

Orthologs for CCZ1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCZ1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCZ1 35
  • 90.36 (n)
  • 97.64 (a)
CCZ1 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCZ1 35
  • 91.72 (n)
  • 97 (a)
-- 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccz1 35
  • 89.01 (n)
  • 96.57 (a)
Ccz1 16
Ccz1 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC463258 35
  • 99.45 (n)
  • 99.59 (a)
-- 36
  • 99 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ccz1 35
  • 89.43 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCZ1 35
  • 83.33 (n)
  • 93.78 (a)
CCZ1 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccz1b 35
  • 77.89 (n)
  • 87.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68831 35
zebrafish
(Danio rerio)
Actinopterygii ccz1 35
  • 76.09 (n)
  • 84.37 (a)
zgc55344 35
ccz1 36
  • 83 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7054 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006687 35
  • 48.65 (n)
  • 36.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14980 35
  • 46 (n)
  • 31.33 (a)
CG14980 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccz-1 35
  • 44.47 (n)
  • 31.09 (a)
ccz-1 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80910 35
  • 43.1 (n)
  • 26.74 (a)
rice
(Oryza sativa)
Liliopsida Os08g0427300 35
  • 39.17 (n)
  • 25.12 (a)
Species with no ortholog for CCZ1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCZ1B Gene

ENSEMBL:
Gene Tree for CCZ1B (if available)
TreeFam:
Gene Tree for CCZ1B (if available)

Paralogs for CCZ1B Gene

Paralogs for CCZ1B Gene

(2) SIMAP similar genes for CCZ1B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCZ1B Gene

genes like me logo Genes that share paralogs with CCZ1B: view

Variants for CCZ1B Gene

Sequence variations from dbSNP and Humsavar for CCZ1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6960305 -- 6,805,515(+) AAAAT(A/G)TGAGC intron-variant
rs6962470 -- 6,827,290(+) attag(A/G)taacg upstream-variant-2KB
rs6966885 -- 6,827,744(+) actcc(G/T)gggct upstream-variant-2KB
rs6970263 -- 6,823,158(+) TAAAC(C/T)TCACT intron-variant, upstream-variant-2KB
rs13226134 -- 6,817,875(+) ggtac(G/T)cacct intron-variant

Variation tolerance for CCZ1B Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCZ1B Gene

HapMap Linkage Disequilibrium report
CCZ1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCZ1B Gene

Disorders for CCZ1B Gene

Relevant External Links for CCZ1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCZ1B

No disorders were found for CCZ1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCZ1B Gene

Publications for CCZ1B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  5. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PMID: 23022380) Yatim A. … Benkirane M. (Mol. Cell 2012) 3

Products for CCZ1B Gene

Sources for CCZ1B Gene

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