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Aliases for CCZ1B Gene

Aliases for CCZ1B Gene

  • CCZ1 Homolog B, Vacuolar Protein Trafficking And Biogenesis Associated 2 3 5
  • CCZ1 Homolog, Vacuolar Protein Trafficking And Biogenesis Associated B 2 3
  • C7orf28B 3 4
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B (S. Cerevisiae) 2
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog B 3
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated B 3
  • Vacuolar Fusion Protein CCZ1 Homolog-Like 4
  • Vacuolar Fusion Protein CCZ1 Homolog B 3
  • Chromosome 7 Open Reading Frame 28B 2
  • Similar To CGI-43 Protein 2
  • H_DJ1163J12.2 3
  • H_NH0577018.2 3

External Ids for CCZ1B Gene

Previous HGNC Symbols for CCZ1B Gene

  • C7orf28B

Previous GeneCards Identifiers for CCZ1B Gene

  • GC07M006836

Summaries for CCZ1B Gene

GeneCards Summary for CCZ1B Gene

CCZ1B (CCZ1 Homolog B, Vacuolar Protein Trafficking And Biogenesis Associated) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. An important paralog of this gene is CCZ1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCZ1B Gene

Genomics for CCZ1B Gene

Regulatory Elements for CCZ1B Gene

Enhancers for CCZ1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G006825 0.9 ENCODE 10.9 +0.6 569 0.9 HDAC1 PKNOX1 ATF1 RB1 CREB3L1 NFRKB ARID4B SIN3A ZBTB40 CHAMP1 CCZ1B PIR61703
GH07G006576 1.1 ENCODE 5.8 +249.2 249238 2.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 SIN3A ARID4B DMAP1 ZBTB7B ZDHHC4 PMS2 CCZ1B PIR51415
GH07G006446 1.4 ENCODE dbSUPER 4.4 +378.0 377986 4.4 MLX CREB3L1 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ZNF610 GLIS1 DAGLB ZNF316 ENSG00000198580 C7orf26 ENSG00000228010 ANKRD61 KDELR2 CCZ1 USP42 RAC1
GH07G006408 1.1 dbSUPER 4.6 +417.1 417119 2.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ZFP64 ARID4B SIN3A DAGLB ENSG00000198580 ENSG00000228010 RAC1 FAM220A CCZ1 ZDHHC4 CCZ1B GC07M006427 PIR50924
GH07G006623 0.9 Ensembl ENCODE 5 +202.6 202578 1.1 PHF8 NRF1 NR2F1 MAX REST POLR2A TARDBP ZNF512 KDM1A PRDM1 ZDHHC4 CCZ1B ZNF853 ZNF316
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCZ1B on UCSC Golden Path with GeneCards custom track

Promoters for CCZ1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000208265 570 1601 PKNOX1 ATF1 RB1 CREB3L1 NFRKB ARID4B SIN3A ZBTB40 CHAMP1 EGR1

Genomic Location for CCZ1B Gene

Chromosome:
7
Start:
6,794,134 bp from pter
End:
6,826,770 bp from pter
Size:
32,637 bases
Orientation:
Minus strand

Genomic View for CCZ1B Gene

Genes around CCZ1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCZ1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCZ1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCZ1B Gene

Proteins for CCZ1B Gene

  • Protein details for CCZ1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86790-CCZ1B_HUMAN
    Recommended name:
    Vacuolar fusion protein CCZ1 homolog B
    Protein Accession:
    P86790
    Secondary Accessions:
    • A2RU45
    • O95766
    • Q9UG65
    • Q9Y359

    Protein attributes for CCZ1B Gene

    Size:
    482 amino acids
    Molecular mass:
    55866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCZ1B Gene

Post-translational modifications for CCZ1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCZ1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCZ1B Gene

Domains & Families for CCZ1B Gene

Protein Domains for CCZ1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCZ1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86790

UniProtKB/Swiss-Prot:

CCZ1B_HUMAN :
  • Belongs to the CCZ1 family.
Family:
  • Belongs to the CCZ1 family.
genes like me logo Genes that share domains with CCZ1B: view

No data available for Gene Families for CCZ1B Gene

Function for CCZ1B Gene

Phenotypes for CCZ1B Gene

genes like me logo Genes that share phenotypes with CCZ1B: view

Animal Model Products

CRISPR Products

miRNA for CCZ1B Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCZ1B Gene

Localization for CCZ1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCZ1B Gene

Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCZ1B gene
Compartment Confidence
cytosol 5
lysosome 4
nucleus 2
endosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CCZ1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016235 aggresome IDA --
GO:0031982 vesicle IBA --
genes like me logo Genes that share ontologies with CCZ1B: view

Pathways & Interactions for CCZ1B Gene

genes like me logo Genes that share pathways with CCZ1B: view

Pathways by source for CCZ1B Gene

Interacting Proteins for CCZ1B Gene

Gene Ontology (GO) - Biological Process for CCZ1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with CCZ1B: view

No data available for SIGNOR curated interactions for CCZ1B Gene

Drugs & Compounds for CCZ1B Gene

No Compound Related Data Available

Transcripts for CCZ1B Gene

Unigene Clusters for CCZ1B Gene

CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCZ1B Gene

No ASD Table

Relevant External Links for CCZ1B Gene

GeneLoc Exon Structure for
CCZ1B
ECgene alternative splicing isoforms for
CCZ1B

Expression for CCZ1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCZ1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CCZ1B Gene:

CCZ1B

SOURCE GeneReport for Unigene cluster for CCZ1B Gene:

Hs.567779

Evidence on tissue expression from TISSUES for CCZ1B Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with CCZ1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCZ1B Gene

Orthologs for CCZ1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCZ1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
ManyToMany
LOC463258 34
  • 99.45 (n)
-- 35
  • 99 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCZ1 34
  • 91.72 (n)
-- 35
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CCZ1 34 35
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Ccz1 34
  • 89.43 (n)
mouse
(Mus musculus)
Mammalia Ccz1 34 16 35
  • 89.01 (n)
chicken
(Gallus gallus)
Aves CCZ1 34 35
  • 83.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccz1b 34
  • 77.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68831 34
zebrafish
(Danio rerio)
Actinopterygii ccz1 34 35
  • 76.09 (n)
zgc55344 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7054 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006687 34
  • 48.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14980 34 35
  • 46 (n)
worm
(Caenorhabditis elegans)
Secernentea ccz-1 34 35
  • 44.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80910 34
  • 43.1 (n)
rice
(Oryza sativa)
Liliopsida Os08g0427300 34
  • 39.17 (n)
Species where no ortholog for CCZ1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCZ1B Gene

ENSEMBL:
Gene Tree for CCZ1B (if available)
TreeFam:
Gene Tree for CCZ1B (if available)

Paralogs for CCZ1B Gene

Paralogs for CCZ1B Gene

(2) SIMAP similar genes for CCZ1B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCZ1B Gene

genes like me logo Genes that share paralogs with CCZ1B: view

Variants for CCZ1B Gene

Sequence variations from dbSNP and Humsavar for CCZ1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000403446 -- 6,821,241(+) TCATG(A/C)CCTCA intron-variant
rs1000405111 -- 6,805,540(+) AGACA(-/G)GGGGG intron-variant
rs1000859159 -- 6,806,273(+) GAGAG(A/G)CACAG intron-variant
rs1001540212 -- 6,824,819(+) TCGAC(C/T)TCTTG intron-variant
rs1001681430 -- 6,827,898(+) TCCAC(C/T)GGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCZ1B Gene

Variant ID Type Subtype PubMed ID
dgv1864e212 CNV loss 25503493
dgv1865e212 CNV loss 25503493
dgv1866e212 CNV loss 25503493
dgv1867e212 CNV loss 25503493
dgv6244n100 CNV loss 25217958
dgv6245n100 CNV gain 25217958
esv2752174 CNV gain 17911159
esv2759504 CNV loss 17122850
esv2762647 CNV gain 21179565
esv33385 CNV gain 17666407
esv3571605 CNV loss 25503493
esv3576287 CNV gain 25503493
esv3576288 CNV gain 25503493
esv3891033 CNV gain 25118596
nsv1017971 CNV gain 25217958
nsv1023133 CNV gain 25217958
nsv1023478 CNV loss 25217958
nsv1126775 CNV deletion 24896259
nsv1161493 OTHER complex 26073780
nsv441808 CNV gain+loss 18776908
nsv7392 OTHER inversion 18451855
nsv966756 CNV duplication 23825009
nsv966757 CNV duplication 23825009
nsv981430 CNV duplication 23825009

Variation tolerance for CCZ1B Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.83; 86.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCZ1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCZ1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCZ1B Gene

Disorders for CCZ1B Gene

Relevant External Links for CCZ1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCZ1B

No disorders were found for CCZ1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCZ1B Gene

Publications for CCZ1B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64

Products for CCZ1B Gene

Sources for CCZ1B Gene

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