CCZ1 Gene
protein-coding GIFtS : 44
GCID: GC07 P005938
CCZ1 vacuolar protein trafficking and biogenesis associated... (Previous name: chromosome 7 open reading frame 28A ) (Previous symbol: C7orf28A )
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Aliasesfor CCZ1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog (S.Cerevisiae) 1 2 Chromosome 7 Open Reading Frame 28A1 C7orf28A1 2 3 H_DJ1163J12.22 CCZ1A1 2 H_NH0577018.22 CGI-431 Vacuolar Fusion Protein CCZ1 Homolog2
Export aliases for CCZ1 gene to outside databases
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Summariesfor CCZ1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CCZ1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CCZ1 Other transcription factors Search SABiosciences Chromatin IP Primers for CCZ1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCZ1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.2 CCZ1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P005938: view genomic region
(about GC identifiers )
Start:
5,938,341 bp from pter
End:
5,965,605 bp from pter
Size:
27,265 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 5,984,686-6,011,950
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Proteinsfor CCZ1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CCZ1_HUMAN, P86791 (See
protein sequence )Recommended Name: Vacuolar fusion protein CCZ1 homolog Size : 482 amino acids; 55866 Da
Subcellular location : Lysosome membrane
Secondary accessions : A2RU45 O95766 Q9UG65 Q9Y359Explore the universe of human proteins at neXtProt for CCZ1: NX_P86791 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P86791 CCZ1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_056437.4 ENSEMBL proteins: ENSP00000325681 ENSP00000444661 Human Recombinant Protein Products for CCZ1: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005765 lysosomal membrane
IEA --
CCZ1 for ontologies About GeneDecksing CCZ1 Antibody Products: Assay Products for CCZ1:
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Protein
Domains / Familiesfor CCZ1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CCZ1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry P86791 ProtoNet protein and cluster: P86791
UniProtKB/Swiss-Prot: CCZ1_HUMAN, P86791 Similarity : Belongs to the CCZ1 family
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Functionfor CCZ1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCZ1 (NM_015622 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCZ1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCZ1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1
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Pathways & Interactionsfor CCZ1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCZ1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for CCZ1 (P86791 3 ENSP00000325681 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor CCZ1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCZ1 Search CenterWatch for drugs/clinical trials and news about CCZ1
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Transcriptsfor CCZ1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCZ1 gene: NM_015622.5 Unigene Cluster for CCZ1:
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) Hs.530000 [show with all ESTs ] Unigene Representative Sequence: BC067810 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000461592 ENST00000325974 (uc003spf.3 ) ENST00000478672 ENST00000483394 ENST00000474507 ENST00000496860 ENST00000537980 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCZ1 (NM_015622 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCZ1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCZ1
Additional cDNA sequence: BC067810.1 BC132749.1 BC132751.1
20 DOTS entries : DT.97856263 DT.100890363
DT.100890368 DT.95258690 DT.121128018 DT.121095974 DT.121128037 DT.121128051 DT.92072227 DT.100890383 DT.121096001 DT.121128015 DT.121128041 DT.91748555 DT.91927928 DT.121128033 DT.75159455 DT.92072238 DT.92072242 DT.95258711 24/300 AceView cDNA sequences (see all 300 ):
AI208759 AI309982 AA379841 BQ889481 BQ028327 AL554597 CR590431 CR595861 BG113949 BQ938093 BU684846 AA835425 BM992989 AA811971 BE874607 BQ063050 BM761646 BG177605 CR597206 BP341272 BM826046 BE294404 AJ713879 AW189559 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for CCZ1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 SP1 :                   SP2 :       -         -    
ECgene alternative splicing isoforms for CCZ1
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Expression for CCZ1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCZ1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAAGTTAGTGAbout this image CCZ1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See CCZ1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCZ1 SOURCE GeneReport for Unigene cluster: Hs.530000 SABiosciences Custom PCR Arrays for CCZ1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCZ1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat CCZ1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCZ1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCZ1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1
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Orthologsfor CCZ1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCZ1 gene from 8/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for CCZ1 (if available)TreeFam Gene Tree for CCZ1 (if available)
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Paralogsfor CCZ1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CCZ1 gene CCZ1B 1 2 2 SIMAP similar genes for CCZ1 using alignment to 1 protein entry: CCZ1_HUMAN :CCZ1B DKFZp586I1023
CCZ1 for paralogs About GeneDecksing
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Genomic Variantsfor CCZ1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCZ1 (5938341 - 5965605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CCZ1: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor CCZ1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCZ1 for disorders About GeneDecksing 1 disease for CCZ1 : About MalaCards hermansky-pudlak syndrome Export disorders for CCZ1 gene to outside databases
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Publicationsfor CCZ1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCZ1 gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with CCZ1) Utopia : connect your pdf to the dynamic world of online information
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093) 1 , 2 , 3 Lai C.H....Lin W. (2000) Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. (PubMed id 20305638) 1 , 3 Kinchen J.M. and Ravichandran K.S. (2010) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 1 , 2 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 1 , 2 Dephoure N.... Gygi S.P. (2008) Integral and associated lysosomal membrane proteins. (PubMed id 17897319) 1 , 2 Schroeder B.... Hasilik A. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011)
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External Searches for CCZ1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCZ1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCZ1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CCZ1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCZ1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CCZ1 gene: Search GeneIP for patents involving CCZ1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCZ1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCZ1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCZ1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCZ1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCZ1 OriGene 3'-UTR Clone for CCZ1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCZ1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCZ1 OriGene Custom Protein Services for CCZ1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCZ1 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCZ1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCZ1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCZ1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCZ1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCZ1
Search Tocris compounds for CCZ1
CCZ1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCZ1
ThermoFisher Antibody for CCZ1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCZ1
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Aliases for CCZ1
Databases for CCZ1
Disorders / Diseases for CCZ1
Domains / Families for CCZ1
Drugs / Compounds for CCZ1
Expression for CCZ1
Function for CCZ1
Genomic Views for CCZ1
Intellectual Property for CCZ1
Orthologs for CCZ1
Paralogs for CCZ1
Pathways / Interactions for CCZ1
Products for CCZ1
Proteins for CCZ1
Publications for CCZ1
Search Box for CCZ1
Summaries for CCZ1
Transcripts for CCZ1
Variants for CCZ1
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