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Aliases for CCZ1 Gene

Aliases for CCZ1 Gene

  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog (S. Cerevisiae) 2 3
  • C7orf28A 3 4
  • Vacuolar Fusion Protein CCZ1 Homolog 3
  • Chromosome 7 Open Reading Frame 28A 2
  • H_DJ1163J12.2 3
  • H_NH0577018.2 3
  • CGI-43 3
  • CCZ1A 3

External Ids for CCZ1 Gene

Previous HGNC Symbols for CCZ1 Gene

  • C7orf28A

Previous GeneCards Identifiers for CCZ1 Gene

  • GC07P005938

Summaries for CCZ1 Gene

GeneCards Summary for CCZ1 Gene

CCZ1 (CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is CCZ1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCZ1 Gene

Genomics for CCZ1 Gene

Genomic Location for CCZ1 Gene

Start:
5,898,710 bp from pter
End:
5,925,974 bp from pter
Size:
27,265 bases
Orientation:
Plus strand

Genomic View for CCZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCZ1 Gene

No data available for Regulatory Elements for CCZ1 Gene

Proteins for CCZ1 Gene

  • Protein details for CCZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86791-CCZ1_HUMAN
    Recommended name:
    Vacuolar fusion protein CCZ1 homolog
    Protein Accession:
    P86791
    Secondary Accessions:
    • A2RU45
    • O95766
    • Q9UG65
    • Q9Y359

    Protein attributes for CCZ1 Gene

    Size:
    482 amino acids
    Molecular mass:
    55866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCZ1 Gene

Proteomics data for CCZ1 Gene at MOPED

Post-translational modifications for CCZ1 Gene

  • Ubiquitination at Lys113, Lys246, Lys295, Lys365, Lys396, and Lys456
  • Modification sites at PhosphoSitePlus

Other Protein References for CCZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCZ1 Gene

Domains for CCZ1 Gene

Protein Domains for CCZ1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86791

UniProtKB/Swiss-Prot:

CCZ1_HUMAN :
  • P86791
Family:
  • Belongs to the CCZ1 family.
genes like me logo Genes that share domains with CCZ1: view

No data available for Gene Families for CCZ1 Gene

Function for CCZ1 Gene

Animal Model Products

CRISPR Products

miRNA for CCZ1 Gene

miRTarBase miRNAs that target CCZ1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCZ1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCZ1 Gene

Localization for CCZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCZ1 Gene

Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCZ1 Gene COMPARTMENTS Subcellular localization image for CCZ1 gene
Compartment Confidence
lysosome 5
vacuole 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane --
GO:0031988 membrane-bounded vesicle IBA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CCZ1: view

Pathways for CCZ1 Gene

SuperPathways for CCZ1 Gene

No Data Available

Interacting Proteins for CCZ1 Gene

Gene Ontology (GO) - Biological Process for CCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with CCZ1: view

No data available for Pathways by source for CCZ1 Gene

Transcripts for CCZ1 Gene

mRNA/cDNA for CCZ1 Gene

Unigene Clusters for CCZ1 Gene

CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCZ1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCZ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - -

Relevant External Links for CCZ1 Gene

GeneLoc Exon Structure for
CCZ1
ECgene alternative splicing isoforms for
CCZ1

Expression for CCZ1 Gene

mRNA expression in normal human tissues for CCZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCZ1 Gene

SOURCE GeneReport for Unigene cluster for CCZ1 Gene Hs.530000

genes like me logo Genes that share expressions with CCZ1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCZ1 Gene

Orthologs for CCZ1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
LOC463258 35
  • 99.45 (n)
  • 99.59 (a)
cow
(Bos Taurus)
Mammalia CCZ1 35
  • 90.36 (n)
  • 97.64 (a)
CCZ1 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
CCZ1 35
  • 91.72 (n)
  • 97 (a)
mouse
(Mus musculus)
Mammalia Ccz1 35
  • 88.87 (n)
  • 96.57 (a)
Ccz1 16
Ccz1 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccz1 35
  • 89.31 (n)
  • 97.36 (a)
chicken
(Gallus gallus)
Aves CCZ1 35
  • 83.26 (n)
  • 93.78 (a)
CCZ1 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccz1b 35
  • 77.81 (n)
  • 87.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ccz1 35
  • 76.02 (n)
  • 84.37 (a)
ccz1 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006687 35
  • 48.65 (n)
  • 36.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14980 35
  • 46.07 (n)
  • 31.33 (a)
CG14980 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccz-1 35
  • 44.55 (n)
  • 31.09 (a)
ccz-1 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80910 35
  • 43.1 (n)
  • 26.74 (a)
rice
(Oryza sativa)
Liliopsida Os08g0427300 35
  • 39.25 (n)
  • 25.12 (a)
Species with no ortholog for CCZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCZ1 Gene

ENSEMBL:
Gene Tree for CCZ1 (if available)
TreeFam:
Gene Tree for CCZ1 (if available)

Paralogs for CCZ1 Gene

Paralogs for CCZ1 Gene

Selected SIMAP similar genes for CCZ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCZ1: view

Variants for CCZ1 Gene

Sequence variations from dbSNP and Humsavar for CCZ1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1138495 -- 5,910,095(+) CTTTT(C/T)CCAAG synonymous-codon, reference
rs1468403 -- 5,908,324(+) AAAAA(C/T)TTGTC intron-variant
rs2024002 -- 5,901,281(+) GGGGT(C/T)CGAGA intron-variant
rs2024003 -- 5,901,578(+) AGAGT(C/T)AGTGT intron-variant
rs2072191 -- 5,923,657(+) ATGGG(C/T)GCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCZ1 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887420 CNV Gain 21882294
nsv830892 CNV Loss 17160897
nsv830894 CNV Loss 17160897
esv2663734 CNV Deletion 23128226
esv274969 CNV Loss 21479260
esv2421482 CNV Deletion 20811451

Relevant External Links for CCZ1 Gene

HapMap Linkage Disequilibrium report
CCZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCZ1 Gene

Disorders for CCZ1 Gene

No disorders were found for CCZ1 Gene.

No data available for UniProtKB/Swiss-Prot for CCZ1 Gene

Publications for CCZ1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4

Products for CCZ1 Gene

Sources for CCZ1 Gene

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