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Aliases for CCZ1 Gene

Aliases for CCZ1 Gene

  • CCZ1 Homolog, Vacuolar Protein Trafficking And Biogenesis Associated 2 3 5
  • C7orf28A 3 4
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog (S. Cerevisiae) 2
  • CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated Homolog 3
  • Chromosome 7 Open Reading Frame 28A 2
  • H_DJ1163J12.2 3
  • H_NH0577018.2 3
  • CGI-43 3
  • CCZ1A 3

External Ids for CCZ1 Gene

Previous HGNC Symbols for CCZ1 Gene

  • C7orf28A

Previous GeneCards Identifiers for CCZ1 Gene

  • GC07P005938

Summaries for CCZ1 Gene

GeneCards Summary for CCZ1 Gene

CCZ1 (CCZ1 Homolog, Vacuolar Protein Trafficking And Biogenesis Associated) is a Protein Coding gene. An important paralog of this gene is CCZ1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCZ1 Gene

Genomics for CCZ1 Gene

Regulatory Elements for CCZ1 Gene

Enhancers for CCZ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCZ1 on UCSC Golden Path with GeneCards custom track

Promoters for CCZ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCZ1 Gene

Chromosome:
7
Start:
5,898,710 bp from pter
End:
5,926,550 bp from pter
Size:
27,841 bases
Orientation:
Plus strand

Genomic View for CCZ1 Gene

Genes around CCZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCZ1 Gene

Proteins for CCZ1 Gene

  • Protein details for CCZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86791-CCZ1_HUMAN
    Recommended name:
    Vacuolar fusion protein CCZ1 homolog
    Protein Accession:
    P86791
    Secondary Accessions:
    • A2RU45
    • O95766
    • Q9UG65
    • Q9Y359

    Protein attributes for CCZ1 Gene

    Size:
    482 amino acids
    Molecular mass:
    55866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCZ1 Gene

Proteomics data for CCZ1 Gene at MOPED

Post-translational modifications for CCZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCZ1 Gene

Domains & Families for CCZ1 Gene

Protein Domains for CCZ1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86791

UniProtKB/Swiss-Prot:

CCZ1_HUMAN :
  • Belongs to the CCZ1 family.
Family:
  • Belongs to the CCZ1 family.
genes like me logo Genes that share domains with CCZ1: view

No data available for Gene Families for CCZ1 Gene

Function for CCZ1 Gene

Phenotypes for CCZ1 Gene

genes like me logo Genes that share phenotypes with CCZ1: view

Animal Model Products

CRISPR Products

miRNA for CCZ1 Gene

miRTarBase miRNAs that target CCZ1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCZ1 Gene

Localization for CCZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCZ1 Gene

Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCZ1 Gene COMPARTMENTS Subcellular localization image for CCZ1 gene
Compartment Confidence
lysosome 4
vacuole 4
cytosol 2
endosome 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CCZ1: view

Pathways & Interactions for CCZ1 Gene

SuperPathways for CCZ1 Gene

No Data Available

Interacting Proteins for CCZ1 Gene

Gene Ontology (GO) - Biological Process for CCZ1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCZ1 Gene

Drugs & Compounds for CCZ1 Gene

No Compound Related Data Available

Transcripts for CCZ1 Gene

Unigene Clusters for CCZ1 Gene

CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCZ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - -

Relevant External Links for CCZ1 Gene

GeneLoc Exon Structure for
CCZ1
ECgene alternative splicing isoforms for
CCZ1

Expression for CCZ1 Gene

mRNA expression in normal human tissues for CCZ1 Gene

Protein differential expression in normal tissues from HIPED for CCZ1 Gene

This gene is overexpressed in Breast (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCZ1 Gene



SOURCE GeneReport for Unigene cluster for CCZ1 Gene Hs.530000

genes like me logo Genes that share expression patterns with CCZ1: view

Protein tissue co-expression partners for CCZ1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCZ1 Gene

Orthologs for CCZ1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCZ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCZ1 35
  • 90.36 (n)
  • 97.64 (a)
CCZ1 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCZ1 35
  • 91.72 (n)
  • 97 (a)
-- 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccz1 35
  • 88.87 (n)
  • 96.57 (a)
Ccz1 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC463258 35
  • 99.45 (n)
  • 99.59 (a)
-- 36
  • 99 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ccz1 35
  • 89.31 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCZ1 35
  • 83.26 (n)
  • 93.78 (a)
CCZ1 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccz1b 35
  • 77.81 (n)
  • 87.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ccz1 35
  • 76.02 (n)
  • 84.37 (a)
ccz1 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006687 35
  • 48.65 (n)
  • 36.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14980 35
  • 46.07 (n)
  • 31.33 (a)
CG14980 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccz-1 35
  • 44.55 (n)
  • 31.09 (a)
ccz-1 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80910 35
  • 43.1 (n)
  • 26.74 (a)
rice
(Oryza sativa)
Liliopsida Os08g0427300 35
  • 39.25 (n)
  • 25.12 (a)
Species with no ortholog for CCZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCZ1 Gene

ENSEMBL:
Gene Tree for CCZ1 (if available)
TreeFam:
Gene Tree for CCZ1 (if available)

Paralogs for CCZ1 Gene

Paralogs for CCZ1 Gene

(2) SIMAP similar genes for CCZ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCZ1: view

Variants for CCZ1 Gene

Sequence variations from dbSNP and Humsavar for CCZ1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1138495 -- 5,910,095(+) CTTTT(C/T)CCAAG reference, synonymous-codon
rs1468403 -- 5,908,324(+) AAAAA(C/T)TTGTC intron-variant
rs6972493 -- 5,908,676(+) cgccc(A/G)accAC intron-variant
rs6973085 -- 5,903,071(+) TGATA(C/G)ATTAG intron-variant
rs6973988 -- 5,902,865(+) AAGAG(C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCZ1 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887420 CNV Gain 21882294
nsv830892 CNV Loss 17160897
nsv830894 CNV Loss 17160897
esv2663734 CNV Deletion 23128226
esv274969 CNV Loss 21479260
esv2421482 CNV Deletion 20811451

Variation tolerance for CCZ1 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCZ1 Gene

Disorders for CCZ1 Gene

Relevant External Links for CCZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCZ1

No disorders were found for CCZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCZ1 Gene

Publications for CCZ1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. (PMID: 20305638) Kinchen J.M. … Ravichandran K.S. (Nature 2010) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3
  5. Mutants of the Saccharomyces cerevisiae VPS genes CCZ1 and YPT7 are blocked in different stages of sporulation. (PMID: 20709422) Piekarska I. … Rempola B. (Eur. J. Cell Biol. 2010) 3

Products for CCZ1 Gene

Sources for CCZ1 Gene

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