CCT8L2 Gene
protein-coding GIFtS: 39
GCID: GC22M017071
|
|
chaperonin containing TCP1, subunit 8 (theta)-like 2
| |
Aliases
for CCT8L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 21 2 | | CESK11 2 3 | | Putative T-Complex Protein 1 Subunit Theta-Like 22 | | T-Complex Protein 12 |
Export aliases for CCT8L2 gene to outside databasesPrevious GC identifers: GC22M015451 GC22M000891 |
Summaries
for CCT8L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TCPQM_HUMAN, Q96SF2Function: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity)
|
Genomic Views
for CCT8L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCT8L2 gene promoter:
HOXA9B HOXA9 HTF Meis-1b NF-AT NF-AT4 NF-AT2 NF-AT3 Meis-1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCT8L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT8L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.1 Ensembl cytogenetic band: 22q11.1 HGNC cytogenetic band: 22q11.1CCT8L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M017071: view genomic region
(about GC identifiers)
Start:
|
17,071,648 bp from pter |
End:
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17,073,700 bp from pter |
Size:
|
2,053 bases |
Orientation:
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minus strand |
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Proteins
for CCT8L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCPQM_HUMAN, Q96SF2 (See
protein sequence)Recommended Name: Putative T-complex protein 1 subunit theta-like 2 Size: 557 amino acids; 59388 Da
Subcellular location: Cytoplasm (By similarity)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAI39843.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknownorigin in the C-terminal part;
Secondary accessions: A4QPH3 Q9UJS3Explore the universe of human proteins at neXtProt for CCT8L2: NX_Q96SF2
CCT8L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055221.1
ENSEMBL proteins: ENSP00000353048
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CCT8L2 for ontologies About GeneDecksing
CCT8L2 Antibody Products:
Assay Products for CCT8L2: |
Protein
Domains /
Families
for CCT8L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCT8L2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SF2ProtoNet protein and cluster: Q96SF2 UniProtKB/Swiss-Prot: TCPQM_HUMAN, Q96SF2Similarity: Belongs to the TCP-1 chaperonin family |
Function
for CCT8L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCPQM_HUMAN, Q96SF2Function: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CCT8L2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8L2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CCT8L2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CCT8L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT8L2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CCT8L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCT8L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCT8L2
Search CenterWatch for drugs/clinical trials and news about CCT8L2 / TCPQM
|
Transcripts
for CCT8L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCT8L2 gene: NM_014406.4 Unigene Cluster for CCT8L2: Chaperonin containing TCP1, subunit 8 (theta)-like 2 Hs.128342 [show with all ESTs]Unigene Representative Sequence: NM_0144061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000359963(uc002zlp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCT8L2 (NM_014406) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCT8L2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8L2 |
Additional cDNA sequence: BC022006.1 BC033797.1 BC100811.2 BC100812.2 BC100813.1 BC139842.1 CR456508.1 1 DOTS entry: DT.105092 17 AceView cDNA sequences: BC033797 AI221641 BX109995 NM_014406 AA974111 AA969090 BG723375 BG772549 BI831030 BM560079 BC022006 BM559457 BI562144 CR456508 BI459091 AW014427 BI829375
GeneLoc Exon Structure
|
Expression
for CCT8L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCT8L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAAAAAA
About this image
See CCT8L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCT8L2
SOURCE GeneReport for Unigene cluster: Hs.128342
SABiosciences Custom PCR Arrays for CCT8L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT8L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCT8L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT8L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8L2 |
Orthologs
for CCT8L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCT8L2 gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NEF2_CHICK6 |
chaperonin containing TCP1, subunit 8 (theta) |
29(a) |
possible ortholog |
1(107461264-107472468) |
lizard
(Anolis carolinensis) |
Reptilia |
CCT8L26CCT86 |
-- |
37(a)29(a) |
1 ↔ 1possible ortholog |
GL343655.1(160673-162319) 3(146563678-146577394) |
zebrafish
(Danio rerio) |
Actinopterygii |
cct86 |
chaperonin containing TCP1, subunit 8 (theta) |
30(a) |
possible ortholog |
10(25963452-25979373) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG82586 |
-- |
29(a) |
possible ortholog |
2R(4792347-4794506) |
worm
(Caenorhabditis elegans) |
Secernentea |
cct-86 |
T-complex protein 1 subunit theta |
25(a) |
possible ortholog |
IV(1087575-1093920) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G039606 |
TCP-1/cpn60 chaperonin family protein |
25(a) |
possible ortholog |
3(1024258-1027891) |
rice
(Oryza sativa) |
Liliopsida |
-- |
T-complex protein, putative, expressed |
25(a) |
possible ortholog |
3(33585622-33590944) |
ENSEMBL Gene Tree for CCT8L2 (if available)
TreeFam Gene Tree for CCT8L2 (if available) |
Paralogs
for CCT8L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCT8L2 gene
- CCT82
2 SIMAP similar genes for CCT8L2 using alignment to 1 protein entry: TCPQM_HUMAN:CCT8L1P CCT8
CCT8L2 for paralogs About GeneDecksing
|
Genomic Variants
for CCT8L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCT8L2 (17071648 - 17073700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CCT8L2
11 CNVs: 29713 29714 5350 34559 5351 50793 4115 53817 8898 53732 50794 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT8L2 |
|
Disorders
/ Diseases
for CCT8L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCT8L2 for disorders About GeneDecksing
4  diseases for CCT8L2: About MalaCardspneumonia tuberculosis malaria mycobacterium tuberculosis
Export disorders for CCT8L2 gene to outside databases
|
Publications
for CCT8L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCT8L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCT8L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PubMed id 10585773)1, 2 Riazi M.A.... McDermid H.E. (1999)
- Chaperonin genes on the rise: new divergent classes a nd intense duplication in human and other vertebrate genomes. (PubMed id 20193073)1 Mukherjee K....Brocchieri L. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
|
External Searches for CCT8L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCT8L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCT8L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCT8L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCT8L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCT8L2 gene:
Search GeneIP for patents involving CCT8L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCT8L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | CCT8L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8L2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCT8L2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8L2 |
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