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Aliases for CCT8L2 Gene

Aliases for CCT8L2 Gene

  • Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2 2 3
  • CESK1 3 4
  • Putative T-Complex Protein 1 Subunit Theta-Like 2 3
  • T-Complex Protein 1 3

External Ids for CCT8L2 Gene

Previous GeneCards Identifiers for CCT8L2 Gene

  • GC22M015451
  • GC22M017071
  • GC22M000891

Summaries for CCT8L2 Gene

GeneCards Summary for CCT8L2 Gene

CCT8L2 (Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and anion channel activity. An important paralog of this gene is CCT8.

UniProtKB/Swiss-Prot for CCT8L2 Gene

  • Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8L2 Gene

Genomics for CCT8L2 Gene

Regulatory Elements for CCT8L2 Gene

Genomic Location for CCT8L2 Gene

16,590,751 bp from pter
16,592,810 bp from pter
2,060 bases
Minus strand

Genomic View for CCT8L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8L2 Gene

Proteins for CCT8L2 Gene

  • Protein details for CCT8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 1 subunit theta-like 2
    Protein Accession:
    Secondary Accessions:
    • A4QPH3
    • Q9UJS3

    Protein attributes for CCT8L2 Gene

    557 amino acids
    Molecular mass:
    59388 Da
    Quaternary structure:
    No Data Available
    • Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.
    • Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).
    • Sequence=AAI39843.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for CCT8L2 Gene

Proteomics data for CCT8L2 Gene at MOPED

Post-translational modifications for CCT8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCT8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCT8L2 Gene

Domains for CCT8L2 Gene

Suggested Antigen Peptide Sequences for CCT8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96SF2
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8L2: view

No data available for Gene Families for CCT8L2 Gene

Function for CCT8L2 Gene

Molecular function for CCT8L2 Gene

UniProtKB/Swiss-Prot Function:
Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

Gene Ontology (GO) - Molecular Function for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005253 anion channel activity TAS 10585773
GO:0005524 ATP binding IEA --
GO:0015269 calcium-activated potassium channel activity TAS 10585773
genes like me logo Genes that share ontologies with CCT8L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT8L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCT8L2 Gene

Localization for CCT8L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8L2 Gene


Subcellular locations from

Jensen Localization Image for CCT8L2 Gene COMPARTMENTS Subcellular localization image for CCT8L2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCT8L2: view

Pathways for CCT8L2 Gene

SuperPathways for CCT8L2 Gene

No Data Available

Interacting Proteins for CCT8L2 Gene

Gene Ontology (GO) - Biological Process for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10585773
GO:0006820 anion transport --
GO:0044267 cellular protein metabolic process --
GO:0071805 potassium ion transmembrane transport TAS 10585773
GO:0098656 anion transmembrane transport TAS 10585773
genes like me logo Genes that share ontologies with CCT8L2: view

No data available for Pathways by source for CCT8L2 Gene

Transcripts for CCT8L2 Gene

mRNA/cDNA for CCT8L2 Gene

(17) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCT8L2 Gene

Chaperonin containing TCP1, subunit 8 (theta)-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT8L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8L2 Gene

No ASD Table

Relevant External Links for CCT8L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCT8L2 Gene

mRNA expression in normal human tissues for CCT8L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCT8L2 Gene

This gene is overexpressed in Testis (51.3).

Protein differential expression in normal tissues for CCT8L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCT8L2 Gene

SOURCE GeneReport for Unigene cluster for CCT8L2 Gene Hs.128342

genes like me logo Genes that share expressions with CCT8L2: view

Expression partners for CCT8L2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCT8L2 Gene

Orthologs for CCT8L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT8L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCT8L2 35
  • 74.13 (n)
  • 72.68 (a)
CCT8L2 36
  • 73 (a)
(Canis familiaris)
Mammalia CCT8L2 35
  • 78.07 (n)
  • 73.61 (a)
CCT8L2 36
  • 73 (a)
(Mus musculus)
Mammalia Cct8l1 35
  • 72.81 (n)
  • 65.79 (a)
Cct8l1 16
Cct8l1 36
  • 62 (a)
(Pan troglodytes)
Mammalia CCT8L2 35
  • 99.1 (n)
  • 98.74 (a)
CCT8L2 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Cct8l1 35
  • 70.82 (n)
  • 63.74 (a)
(Monodelphis domestica)
Mammalia CCT8L2 36
  • 54 (a)
(Anolis carolinensis)
Reptilia CCT8L2 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8258 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea cct-8 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 36
  • 26 (a)
Species with no ortholog for CCT8L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CCT8L2 Gene

Gene Tree for CCT8L2 (if available)
Gene Tree for CCT8L2 (if available)

Paralogs for CCT8L2 Gene

Paralogs for CCT8L2 Gene

Selected SIMAP similar genes for CCT8L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCT8L2: view

Variants for CCT8L2 Gene

Sequence variations from dbSNP and Humsavar for CCT8L2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2070503 -- 16,592,585(+) GGTTG(C/T)AGAGA utr-variant-5-prime
rs2236639 - 16,591,593(+) CATCC(A/G)AGACC missense, reference
rs5746662 -- 16,593,260(+) CTCCC(A/G)AAGTG upstream-variant-2KB
rs5746663 -- 16,593,537(+) GTCTC(A/G)AACTC upstream-variant-2KB
rs5746664 -- 16,593,732(+) CTTTG(A/C)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCT8L2 Gene

Variant ID Type Subtype PubMed ID
dgv172e55 CNV Gain 17911159
dgv1376e1 CNV Complex 17122850
dgv18e196 CNV Duplication 17116639
nsv471178 CNV Gain 18288195
nsv517059 CNV Gain+Loss 19592680
nsv527637 CNV Gain 19592680
dgv723n67 CNV Gain 20364138
dgv539n27 CNV Gain 19166990
dgv540n27 CNV Gain 19166990

Relevant External Links for CCT8L2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT8L2 Gene

Disorders for CCT8L2 Gene

No disorders were found for CCT8L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CCT8L2 Gene

Publications for CCT8L2 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  2. Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. (PMID: 20193073) Mukherjee K. … Brocchieri L. (BMC Evol. Biol. 2010) 3 4
  3. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PMID: 10585773) Riazi M.A. … McDermid H.E. (Genomics 1999) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3

Products for CCT8L2 Gene

Sources for CCT8L2 Gene

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