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Aliases for CCT8L2 Gene

Aliases for CCT8L2 Gene

  • Chaperonin Containing TCP1 Subunit 8 Like 2 2 3 5
  • Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2 2 3
  • CESK1 3 4
  • Putative T-Complex Protein 1 Subunit Theta-Like 2 3
  • T-Complex Protein 1 Subunit Theta-Like 2 3

External Ids for CCT8L2 Gene

Previous GeneCards Identifiers for CCT8L2 Gene

  • GC22M015451
  • GC22M017071
  • GC22M000891

Summaries for CCT8L2 Gene

GeneCards Summary for CCT8L2 Gene

CCT8L2 (Chaperonin Containing TCP1 Subunit 8 Like 2) is a Protein Coding gene. GO annotations related to this gene include calcium-activated potassium channel activity and anion channel activity. An important paralog of this gene is CCT8.

UniProtKB/Swiss-Prot for CCT8L2 Gene

  • Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8L2 Gene

Genomics for CCT8L2 Gene

Regulatory Elements for CCT8L2 Gene

Enhancers for CCT8L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G016586 0.8 ENCODE 0.4 +6.4 6445 0.2 HDAC1 LEF1 PKNOX1 JUN BACH1 E2F7 CEBPG ZNF316 ZNF366 FOXK2 KCNMB3P1 CCT8L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCT8L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT8L2 Gene

Chromosome:
22
Start:
16,590,751 bp from pter
End:
16,592,810 bp from pter
Size:
2,060 bases
Orientation:
Minus strand

Genomic View for CCT8L2 Gene

Genes around CCT8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8L2 Gene

Proteins for CCT8L2 Gene

  • Protein details for CCT8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SF2-TCPQM_HUMAN
    Recommended name:
    T-complex protein 1 subunit theta-like 2
    Protein Accession:
    Q96SF2
    Secondary Accessions:
    • A4QPH3
    • Q9UJS3

    Protein attributes for CCT8L2 Gene

    Size:
    557 amino acids
    Molecular mass:
    59388 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Expression of CCT8L2 is confirmed by many ESTs mostly identified from the testis.
    • Presence of two highly similar CCT8L genes (CCT8L1P and CCT8L2) in the genomes of human and chimp and of a single copy in other mammal genomes, including rhesus monkey, suggests that the duplication of this gene occurred in the ape lineage (Hominoidea) after its divergence from the old-world monkeys (Cercopithecidae).
    SequenceCaution:
    • Sequence=AAI39843.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for CCT8L2 Gene

Post-translational modifications for CCT8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCT8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CCT8L2

No data available for DME Specific Peptides for CCT8L2 Gene

Domains & Families for CCT8L2 Gene

Protein Domains for CCT8L2 Gene

Suggested Antigen Peptide Sequences for CCT8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SF2

UniProtKB/Swiss-Prot:

TCPQM_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8L2: view

No data available for Gene Families for CCT8L2 Gene

Function for CCT8L2 Gene

Molecular function for CCT8L2 Gene

UniProtKB/Swiss-Prot Function:
Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.

Gene Ontology (GO) - Molecular Function for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005253 anion channel activity TAS 10585773
GO:0005524 ATP binding IEA --
GO:0015269 calcium-activated potassium channel activity TAS 10585773
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with CCT8L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCT8L2 Gene

Localization for CCT8L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8L2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT8L2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005832 chaperonin-containing T-complex IBA --
genes like me logo Genes that share ontologies with CCT8L2: view

Pathways & Interactions for CCT8L2 Gene

SuperPathways for CCT8L2 Gene

No Data Available

Interacting Proteins for CCT8L2 Gene

Gene Ontology (GO) - Biological Process for CCT8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006458 de novo protein folding IBA --
GO:0006810 transport TAS 10585773
GO:0061077 chaperone-mediated protein folding IBA --
GO:0071805 potassium ion transmembrane transport IEA --
GO:0098656 anion transmembrane transport IEA --
genes like me logo Genes that share ontologies with CCT8L2: view

No data available for Pathways by source and SIGNOR curated interactions for CCT8L2 Gene

Drugs & Compounds for CCT8L2 Gene

No Compound Related Data Available

Transcripts for CCT8L2 Gene

mRNA/cDNA for CCT8L2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCT8L2 Gene

Chaperonin containing TCP1, subunit 8 (theta)-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8L2 Gene

No ASD Table

Relevant External Links for CCT8L2 Gene

GeneLoc Exon Structure for
CCT8L2
ECgene alternative splicing isoforms for
CCT8L2

Expression for CCT8L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT8L2 Gene

mRNA differential expression in normal tissues according to GTEx for CCT8L2 Gene

This gene is overexpressed in Testis (x51.3).

Protein differential expression in normal tissues from HIPED for CCT8L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCT8L2 Gene



Protein tissue co-expression partners for CCT8L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT8L2 Gene:

CCT8L2

SOURCE GeneReport for Unigene cluster for CCT8L2 Gene:

Hs.128342

Evidence on tissue expression from TISSUES for CCT8L2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCT8L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT8L2 Gene

Orthologs for CCT8L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT8L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT8L2 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CCT8L2 34 35
  • 78.07 (n)
cow
(Bos Taurus)
Mammalia CCT8L2 34 35
  • 74.13 (n)
mouse
(Mus musculus)
Mammalia Cct8l1 34 16 35
  • 72.81 (n)
rat
(Rattus norvegicus)
Mammalia Cct8l1 34
  • 70.82 (n)
oppossum
(Monodelphis domestica)
Mammalia CCT8L2 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT8L2 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8258 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cct-8 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 35
  • 26 (a)
OneToMany
Species where no ortholog for CCT8L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CCT8L2 Gene

ENSEMBL:
Gene Tree for CCT8L2 (if available)
TreeFam:
Gene Tree for CCT8L2 (if available)

Paralogs for CCT8L2 Gene

Paralogs for CCT8L2 Gene

(2) SIMAP similar genes for CCT8L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCT8L2: view

Variants for CCT8L2 Gene

Sequence variations from dbSNP and Humsavar for CCT8L2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000946370 -- 16,593,021(+) ATCAA(A/G)TGAAA upstream-variant-2KB
rs1002942513 -- 16,590,686(+) ACTCC(A/G)TCTCT downstream-variant-500B
rs1003147181 -- 16,590,534(+) AAAAA(C/T)ACAAA downstream-variant-500B
rs1003382916 -- 16,594,437(+) TACAT(A/G)TATGC upstream-variant-2KB
rs1005009023 -- 16,593,110(+) GTCCT(C/G)CTGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCT8L2 Gene

Variant ID Type Subtype PubMed ID
dgv1276e212 CNV gain 25503493
dgv18e196 CNV duplication 17116639
dgv4458n100 CNV gain 25217958
dgv4459n100 CNV gain 25217958
dgv4460n100 CNV gain 25217958
dgv4461n100 CNV loss 25217958
dgv4462n100 CNV gain 25217958
dgv539n27 CNV gain 19166990
dgv540n27 CNV gain 19166990
dgv723n67 CNV gain 20364138
dgv7943n54 CNV gain 21841781
dgv7946n54 CNV gain 21841781
dgv818e214 CNV gain 21293372
dgv819e214 CNV gain 21293372
esv2763696 CNV gain 21179565
esv3575399 CNV gain 25503493
esv3575406 CNV gain 25503493
esv3575407 CNV gain 25503493
esv3584480 CNV gain 24956385
esv3584481 CNV gain 24956385
esv3893423 CNV gain 25118596
nsv1056300 CNV loss 25217958
nsv471178 CNV gain 18288195
nsv517059 CNV gain+loss 19592680
nsv527637 CNV gain 19592680
nsv588062 CNV gain 21841781
nsv588071 CNV gain 21841781
nsv962744 CNV duplication 23825009

Variation tolerance for CCT8L2 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT8L2 Gene

Human Gene Mutation Database (HGMD)
CCT8L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT8L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT8L2 Gene

Disorders for CCT8L2 Gene

Relevant External Links for CCT8L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT8L2

No disorders were found for CCT8L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT8L2 Gene

Publications for CCT8L2 Gene

  1. Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. (PMID: 20193073) Mukherjee K. … Brocchieri L. (BMC Evol. Biol. 2010) 3 4 64
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  3. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PMID: 10585773) Riazi M.A. … McDermid H.E. (Genomics 1999) 3 4 64
  4. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CCT8L2 Gene

Sources for CCT8L2 Gene

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