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CCT8L1P Gene

pseudogene   GIFtS: 20
GCID: GC07P152143

Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 1, Pseudogene

(Previous names: chaperonin containing TCP1, subunit 8 (theta)-like 1)
(Previous symbol: CCT8L1)
  Search for CCT8L1P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 1, Pseudogene1 2
CCT8L11 2 3
Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 11

External Ids:    HGNC: 321531   Entrez Gene: 1551002   Ensembl: ENSG000000202197   UniProtKB: A6NM433   

Export aliases for CCT8L1P gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCT8L1P Gene:
CCT8L1P (chaperonin containing TCP1, subunit 8 (theta)-like 1, pseudogene) is a pseudogene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPQL_HUMAN, A6NM43
Function: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CCT8L1P
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT8L1P promoter sequence
   Search Chromatin IP Primers for CCT8L1P

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT8L1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

CCT8L1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT8L1P gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P152143:  view genomic region     (about GC identifiers)

Start:
152,142,302 bp from pter      End:
152,144,354 bp from pter
Size:
2,053 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 151,469,473-151,471,525     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCPQL_HUMAN, A6NM43 (See protein sequence)
Recommended Name: Putative T-complex protein 1 subunit theta-like 1  
Size: 557 amino acids; 59514 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for CCT8L1P: NX_A6NM43

Explore proteomics data for CCT8L1P at MOPED


See CCT8L1P Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR017998 Chaperone_TCP-1
 IPR027410 TCP-1-like_intermed
 IPR027409 GroEL-like_apical_dom
 IPR012721 Chap_CCT_theta
 IPR002423 Cpn60/TCP-1

Graphical View of Domain Structure for InterPro Entry A6NM43

ProtoNet protein and cluster: A6NM43

UniProtKB/Swiss-Prot: TCPQL_HUMAN, A6NM43
Similarity: Belongs to the TCP-1 chaperonin family


CCT8L1P for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TCPQL_HUMAN, A6NM43
Function: Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005524ATP binding IEA--
     
CCT8L1P for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TCPQL_HUMAN, A6NM43: Cytoplasm (By similarity)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

CCT8L1P for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0044267cellular protein metabolic process IEA--

CCT8L1P for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for CCT8L1P (TCPQL)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CCT8L1P gene: 
NM_001029866.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000465400 ENST00000021776
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCT8L1P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CCT8L1P Expression
About this image

CCT8L1P Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCT8L1P Protein Expression
    Custom PCR Arrays for CCT8L1P
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8L1P

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for CCT8L1P (if available)
TreeFam Gene Tree for CCT8L1P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCT8L1P gene
2 SIMAP similar genes for CCT8L1P using alignment to 1 protein entry:     TCPQL_HUMAN:
CCT8L2    CCT8

CCT8L1P for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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3 SNPs for CCT8L1P    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs69539431,2,4
----see VAR_0460412 mis40--------
rs126721391,2,4
----see VAR_0460402 mis40--------
rs69693041,2,4
----see VAR_0460392 mis40--------

HapMap Linkage Disequilibrium report for CCT8L1P (152142302 - 152144354 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CCT8L1P: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CCT8L1P
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCT8L1P gene integrated from 10 sources:
(articles sorted by number of sources associating them with CCT8L1P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  2. Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. (PubMed id 20193073)1 Mukherjee K....Brocchieri L. (BMC Evol. Biol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 155100 HGNC: 32153 Ensembl:ENSG00000020219 euGenes: HUgn155100 ECgene: CCT8L1P
H-InvDB: CCT8L1P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCT8L1P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCT8L1P gene:
Search GeneIP for patents involving CCT8L1P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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