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Aliases for CCT8 Gene

Aliases for CCT8 Gene

  • Chaperonin Containing TCP1 Subunit 8 2 3 5
  • Chaperonin Containing TCP1, Subunit 8 (Theta) 2 3
  • Renal Carcinoma Antigen NY-REN-15 3 4
  • TCP-1-Theta 3 4
  • C21orf112 3 4
  • CCT-Theta 3 4
  • Cctq 3 4
  • Chromosome 21 Open Reading Frame 112 2
  • T-Complex Protein 1 Subunit Theta 3
  • KIAA0002 4
  • D21S246 3
  • PRED71 3

External Ids for CCT8 Gene

Previous HGNC Symbols for CCT8 Gene

  • C21orf112

Previous GeneCards Identifiers for CCT8 Gene

  • GC21M027007
  • GC21M029350
  • GC21M029349
  • GC21M030428
  • GC21M015834

Summaries for CCT8 Gene

Entrez Gene Summary for CCT8 Gene

  • This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

GeneCards Summary for CCT8 Gene

CCT8 (Chaperonin Containing TCP1 Subunit 8) is a Protein Coding gene. Among its related pathways are Immune System and Organelle biogenesis and maintenance. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot for CCT8 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8 Gene

Genomics for CCT8 Gene

Regulatory Elements for CCT8 Gene

Enhancers for CCT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F029021 0.7 ENCODE 45.8 +49.6 49573 4.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCT8 RPL12P9 LTN1 RWDD2B BACH1-IT1 LINC01697 BACH1-IT2 USP16
GH21F028991 0.2 ENCODE 44.3 +81.0 80980 2.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CCT8 LTN1 RPL12P9 RWDD2B ENSG00000231125 RPL23P2 N6AMT1 USP16 MAP3K7CL GC21M028974
GH21F029071 0.6 ENCODE 39.5 +1.0 1005 3.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 CCT8 LTN1 N6AMT1 RWDD2B RPL23P2 RPL12P9 ENSG00000231125
GH21F029095 1.1 Ensembl ENCODE 39.4 -22.6 -22633 1.7 ZNF639 PKNOX1 INSM2 ZNF843 FOXA1 OSR2 HIC1 CTBP1 ZNF366 ZNF24 CCT8 N6AMT1 GC21P029079 GC21M029128
GH21F028988 0.6 ENCODE 34.2 +85.3 85281 0.7 TSHZ1 FOS CCT8 LTN1 GC21M028976 GC21M028975 GC21M028974
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCT8 on UCSC Golden Path with GeneCards custom track

Promoters for CCT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001840192 397 2401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CCT8 Gene

Chromosome:
21
Start:
29,055,805 bp from pter
End:
29,073,797 bp from pter
Size:
17,993 bases
Orientation:
Minus strand

Genomic View for CCT8 Gene

Genes around CCT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8 Gene

Proteins for CCT8 Gene

  • Protein details for CCT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50990-TCPQ_HUMAN
    Recommended name:
    T-complex protein 1 subunit theta
    Protein Accession:
    P50990
    Secondary Accessions:
    • A6NN54
    • B4DEM7
    • B4DQH4
    • Q4VBP8

    Protein attributes for CCT8 Gene

    Size:
    548 amino acids
    Molecular mass:
    59621 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=BAA02792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT8 Gene

Post-translational modifications for CCT8 Gene

  • Ubiquitination at Lys 7, Lys 37, Lys 54, Lys 62, Lys 152, Lys 171, Lys 225, Lys 235, Lys 254, Lys 260, Lys 421, Lys 440, Lys 459, Lys 466, Lys 528, and Lys 540
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT8 Gene

Domains & Families for CCT8 Gene

Gene Families for CCT8 Gene

Graphical View of Domain Structure for InterPro Entry

P50990

UniProtKB/Swiss-Prot:

TCPQ_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8: view

Function for CCT8 Gene

Molecular function for CCT8 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042623 ATPase activity, coupled TAS 7890169
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IEA,IBA --
genes like me logo Genes that share ontologies with CCT8: view
genes like me logo Genes that share phenotypes with CCT8: view

Animal Model Products

miRNA for CCT8 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT8 Gene

Localization for CCT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT8 Gene COMPARTMENTS Subcellular localization image for CCT8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 25468996
GO:0005813 centrosome IDA 20080638
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with CCT8: view

Pathways & Interactions for CCT8 Gene

genes like me logo Genes that share pathways with CCT8: view

Gene Ontology (GO) - Biological Process for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006458 de novo protein folding IBA --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0046931 pore complex assembly IEA --
genes like me logo Genes that share ontologies with CCT8: view

No data available for SIGNOR curated interactions for CCT8 Gene

Transcripts for CCT8 Gene

Unigene Clusters for CCT8 Gene

Chaperonin containing TCP1, subunit 8 (theta):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - -
SP6: -
SP7:
SP8: - - -
SP9: -
SP10: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CCT8 Gene

GeneLoc Exon Structure for
CCT8
ECgene alternative splicing isoforms for
CCT8

Expression for CCT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCT8 Gene

This gene is overexpressed in Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT8 Gene



Protein tissue co-expression partners for CCT8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT8 Gene:

CCT8

SOURCE GeneReport for Unigene cluster for CCT8 Gene:

Hs.125113
genes like me logo Genes that share expression patterns with CCT8: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT8 Gene

Orthologs for CCT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT8 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
OneToMany
CCT8 34 35
  • 93.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CCT8 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT8 34 35
  • 93.13 (n)
rat
(Rattus norvegicus)
Mammalia Cct8 34
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Cct8 34 16 35
  • 88.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCT8 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT8 34 35
  • 83.15 (n)
lizard
(Anolis carolinensis)
Reptilia CCT8 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct8 34
  • 76.39 (n)
Str.7327 34
African clawed frog
(Xenopus laevis)
Amphibia cct8-prov 34
zebrafish
(Danio rerio)
Actinopterygii cct8 34 35
  • 75.95 (n)
zgc56059 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9154 34
fruit fly
(Drosophila melanogaster)
Insecta CG8258 36 34 35
  • 60.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010588 34
  • 57.98 (n)
worm
(Caenorhabditis elegans)
Secernentea cct-8 34 35
  • 59.53 (n)
Y55F3AR.3 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 34 35 37
  • 53.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09350g 34
  • 53.86 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR045W 34
  • 53.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03960 34
  • 55.96 (n)
rice
(Oryza sativa)
Liliopsida Os03g0804800 34
  • 57.63 (n)
Os.20293 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4432 35
  • 65 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct8 34
  • 56.99 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07567 34
  • 53.55 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5094 34
Species where no ortholog for CCT8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT8 Gene

ENSEMBL:
Gene Tree for CCT8 (if available)
TreeFam:
Gene Tree for CCT8 (if available)

Paralogs for CCT8 Gene

Paralogs for CCT8 Gene

(8) SIMAP similar genes for CCT8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT8 Gene

genes like me logo Genes that share paralogs with CCT8: view

Variants for CCT8 Gene

Sequence variations from dbSNP and Humsavar for CCT8 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs10597265 -- 29,066,101(+) AAAAA(-/A)TTTAG intron-variant
rs1064019 -- 29,059,824(+) AAAGC(G/T)GAAAT intron-variant
rs10708433 -- 29,057,167(+) TTAGC(-/T)TTTTT intron-variant
rs11088106 -- 29,057,328(+) cacca(C/T)gcccg intron-variant
rs11088107 -- 29,058,782(+) AGAGA(C/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT8 Gene

Variant ID Type Subtype PubMed ID
esv3893402 CNV gain 25118596
nsv1114282 CNV deletion 24896259
nsv3485 CNV deletion 18451855

Variation tolerance for CCT8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT8 Gene

Disorders for CCT8 Gene

Relevant External Links for CCT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT8

No disorders were found for CCT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT8 Gene

Publications for CCT8 Gene

  1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PMID: 7890169) Kubota H. … Willison K. (Gene 1995) 2 3 4 22 64
  2. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4 64

Products for CCT8 Gene

Sources for CCT8 Gene

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