Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT8 Gene

protein-coding   GIFtS: 63
GCID: GC21M030428

chaperonin containing TCP1, subunit 8 (theta)

(Previous name: chromosome 21 open reading frame 112 )
(Previous symbol: C21orf112)
 Explore 11 diseases affiliated with
CCT8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCT8    

Aliases
for CCT8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Chaperonin Containing TCP1, Subunit 8 (Theta)1 2     TCP-1-Theta1
C21orf1121 2 3     Chromosome 21 Open Reading Frame 1121
Cctq1 2     D21S2462
PRED711 2     T-Complex Protein 1 Subunit Theta2
T-Complex Protein 1, Theta Subunit2 11     CCTQ3
Renal Carcinoma Antigen NY-REN-152 3     KIAA00023
CCT-Theta1     

External Ids:    HGNC: 16231   Entrez Gene: 106942   Ensembl: ENSG000001562617   UniProtKB: P509903   

Export aliases for CCT8 gene to outside databases

Previous GC identifers: GC21M027007 GC21M029350 GC21M029349 GC21M015834


Summaries
for CCT8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may
play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT8


Genomic Views
for CCT8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT8 gene promoter:
         AhR   LCR-F1   AP-2gamma   Meis-1b   Arnt   POU2F1   POU2F1a   FOXJ2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCT8 promoter sequence

   Search SABiosciences Chromatin IP Primers for CCT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q22.11
CCT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M030428:   GeneLoc Nature:405,311-319
Start:
 30,428,126 bp from pter       16,006,583 bp from centromere
End:
 30,446,118 bp from pter 16,022,451 bp from centromere
Size:
 17,993 bases 15,869 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: D13627
genomic clones: P100J12 P79E4


Proteins
for CCT8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990 (See protein sequence)
Recommended Name: T-complex protein 1 subunit theta  
Size: 548 amino acids; 59621 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome
Sequence caution: Sequence=BAA02792.2; Type=Erroneous initiation;
Secondary accessions: A6NN54 Q4VBP8

Explore the universe of human proteins at neXtProt for CCT8: NX_P50990

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50990

    • CCT8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006576.2  
    ENSEMBL proteins: 
     ENSP00000407748   ENSP00000373811   ENSP00000286788   ENSP00000416832   ENSP00000444984  
     ENSP00000442730  
    Reactome Protein details: P50990
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CCT8
    OriGene Protein Over-expression Lysate: CCT8
    OriGene Custom Protein Services for CCT8 
    GenScript Custom Purified and Recombinant Proteins Services for CCT8
    Novus Biologicals CCT8 Protein
    Novus Biologicals CCT8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCT8

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IDA--
    GO:0016235aggresome IDA--


    CCT8 for ontologies           About GeneDecksing



    CCT8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: CCT8
    OriGene Custom Antibody Services for CCT8 
    GenScript Custom Superior Antibodies Services for CCT8
    Novus Biologicals CCT8 Antibodies
    Abcam antibodies for CCT8 
    Uscn Antibodies for CCT8
    ThermoFisher Antibody for CCT8

    Assay Products for CCT8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCT8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCT8

    Protein Domains /
    Families
    for CCT8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCT8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR012721 Chap_CCT_theta
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P50990

    ProtoNet protein and cluster: P50990

    1 Blocks protein family: IPB002194 Chaperonin TCP-1

    UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
    Similarity: Belongs to the TCP-1 chaperonin family


    Function
    for CCT8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may
    play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
    Known to play a role, in vitro, in the folding of actin and tubulin

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CCT8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT8:
    hsa-miR-570
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT8 (see all 7)
    OriGene shRNA RFP: CCT8
    OriGene siRNA: CCT8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCT8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCT8 (NM_006585)
    Sino Biological Human cDNA Clone for CCT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCT8
    Search LifeMap BioReagents cell lines for CCT8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0042623ATPase activity, coupled TAS7890169
    GO:0051082unfolded protein binding IEA--


    CCT8 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for CCT8:
     Cell division defect  Increased S DNA content, incre  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 


    Pathways & Interactions
    for CCT8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of tubulin folding intermediates by CCT/TriC
    		Formation of tubulin folding intermediates by CCT/TriC1.00
    		Prefoldin mediated transfer of substrate to CCT/TriC0.70
    		Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    		Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    		Chaperonin-mediated protein folding1.00
    		Association of TriC/CCT with target proteins during biosynthesis0.60
    		Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    		Cell cycle Role of APC in cell cycle regulation1.00
    		Cell cycle_Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCT8
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT8
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT8 (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/974 Interacting proteins for CCT8 (P509902, 3 ENSP000002867884) via UniProtKB, MINT, STRING, and/or I2D (see all 974)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--


    CCT8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCT8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT8
    Search CenterWatch for drugs/clinical trials and news about CCT8 / TCPQ 

    Transcripts
    for CCT8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCT8 gene: 
    NM_006585.2  

    Unigene Cluster for CCT8:

    Chaperonin containing TCP1, subunit 8 (theta)
    Hs.125113  [show with all ESTs]
    Unigene Representative Sequence: BC012584
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432178 ENST00000496121 ENST00000470450(uc002yna.3) ENST00000389159
    ENST00000286788(uc002ynb.3 uc011acq.2) ENST00000480359 ENST00000475205
    ENST00000431234 ENST00000484403 ENST00000481059 ENST00000494296 ENST00000542732(uc011acp.2)
    ENST00000540844

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCT8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT8:
    hsa-miR-570
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT8 (see all 7)
    OriGene shRNA RFP: CCT8
    OriGene siRNA: CCT8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCT8 (NM_006585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCT8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8

    Additional cDNA sequence: 

    AK222490.1 AK293705.1 AK298801.1 AK308063.1 BC005220.1 BC012584.1 BC035472.1 BC072001.1 
    BC095470.1 D13627.1 

    24/40 DOTS entries (see all 40):

    DT.447995  DT.100685150  DT.100685126  DT.40233228  DT.91915597  DT.100685139  DT.95094734  DT.95094776 
    DT.95094777  DT.100712494  DT.95094770  DT.75127819  DT.121142275  DT.40117402  DT.95094748  DT.100685148 
    DT.121142263  DT.86819476  DT.92461930  DT.97864568  DT.121142174  DT.121142262  DT.100685124  DT.100685145 

    24/839 AceView cDNA sequences (see all 839):

    BM827018 BM468064 BC072001 BU183236 AW518890 BG028663 BU526498 BE268108 
    Z37163 BM663631 BP363495 BE743819 BQ055520 BE795851 BG489939 CR594631 
    BQ937871 BX279627 BQ649831 BU154051 CR604257 BQ673248 BQ888853 AL540908 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                    -     -     -                                   -                                                                                       
    SP2:                                                                    -                                         -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                          -     -     -     -                       -                                                                                       

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CCT8

    Expression
    for CCT8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAAAACCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCT8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT8

    SOURCE GeneReport for Unigene cluster: Hs.125113
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCT8: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCT8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8

    Orthologs
    for CCT8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT8 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCT81 chaperonin containing TCP1, subunit 8 (theta) 83.15(n)
    93.42(a)    		   418486  NM_001004389.1  NP_001004389.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCT86
    CCT8L26
    		 --
    		 90(a)
    47(a)
    		 1 ↔ 1
    possible ortholog
    		 3(146563678-146577394)
    GL343655.1(160673-162319)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cct8-prov2 chaperonin containing TCP1, subunit 8 (theta) 77.09(n)    BC045040.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc560592 similar to chaperonin containing TCP1, subunit 8 (theta) 77.17(n)   394037  BC050492.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG82581 , 3 chaperonin ATPase3
    CG82581    		 62(a)3
    60.24(n)1
    62.73(a)1    		   44F53
    358821  NM_136574.21  NP_610418.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55F3AR.33
    cct-81    		 Protein CCT-81 52(a)3
    59.47(n)1
    58.3(a)1    		   IV(1087818-1093919)3
    1769281  NM_067634.31  NP_500035.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CCT8(YJL008C)4
    CCT81    		 Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct8p1    		 53.93(n)1
    47.53(a)1    		   10(421663-419957)4
    8534471, 4  NP_012526.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G039601 TCP-1/cpn60 chaperonin family protein 55.83(n)
    51.43(a)    		   819549  NM_111267.4  NP_566219.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.202932 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.42(n)    AK100651.1 


    ENSEMBL Gene Tree for CCT8 (if available)
    TreeFam Gene Tree for CCT8 (if available) 

    Paralogs
    for CCT8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT8 gene
    CCT8L22  
    8 SIMAP similar genes for CCT8 using alignment to 6 protein entries:     TCPQ_HUMAN (see all proteins):
    CCT5    CCT8L1P    CCT4    CCT8L2    CCT3    CCT2
    CCT7    TCP1

    CCT8 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCT8
    PGOHUM00000259481 PGOHUM00000263271


    Genomic Variants
    for CCT8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/375 NCBI SNPs in CCT8 are shown (see all 375)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873333171,2
    		--30428169(+) ACTGAC/TTTAAT 1 -- ds50010--------
    rs2005178631,2
    		--30428173(+) ACTTA-/ATTTTGT 1 -- ds50010--------
    rs350242711,2
    		C,F,H,--30428218(+) TGTACT/CTTGCT 1 -- ds50015Minor allele frequency- C:0.02NS NA 798
    rs1388817521,2
    		--30428238(+) GTCTTC/GAACAA 1 -- ds50010--------
    rs622223751,2
    		--30428345(+) CCTGTA/GGAGGG 1 -- ds50012Minor allele frequency- G:0.07NA 122
    rs760021841,2
    		--30428356(+) CCAGAT/GAGTAA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1433538101,2
    		--30428546(+) CTTACA/GTAAGT 1 -- ds50010--------
    rs1475344721,2
    		--30428579(+) TAATGA/TGATTA 1 -- ds50010--------
    rs1917126671,2
    		--30428587(+) TTAACA/GAGGTT 1 -- ds50010--------
    rs1835648021,2
    		--30428671(+) TTATTA/GTAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCT8 (30428126 - 30446118 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCT8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT8
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT8

    Disorders / Diseases
    for CCT8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCT8 for disorders           About GeneDecksing

    11 diseases for CCT8:    About MalaCards
    renal carcinoma    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3
    carcinoma    renal cell carcinoma    cerebritis    pneumonia
    tuberculosis    malaria    mycobacterium tuberculosis


    Export disorders for CCT8 gene to outside databases

    Publications
    for CCT8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT8 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with CCT8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PubMed id 7890169)1, 2, 3, 9 Kubota H.... Willison K. (1995)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    8. Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21. (PubMed id 8590283)1, 2 Yamazaki M.... Nomura T. (1995)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for CCT8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCT8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10694 HGNC: 1623 AceView: CCT8 Ensembl:ENSG00000156261 euGenes: HUgn10694
    ECgene: CCT8 H-InvDB: CCT8

    Other Databases showing CCT8 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0002

    Specialized Databases showing CCT8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCT8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCT8 gene:
    Search GeneIP for patents involving CCT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCT8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CCT8   OriGene shRNA RFP for CCT8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT8  
     OriGene Protein Over-expression Lysate for CCT8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CCT8   OriGene 3'-UTR Clone for CCT8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CCT8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCT8   OriGene Custom Protein Services for CCT8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCT8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT8
     GenScript Custom Purified and Recombinant Proteins Services for CCT8 GenScript cDNA clones with any tag delivered in your preferred vector for CCT8
     GenScript Custom Assay Services for CCT8 GenScript Custom Superior Antibodies Services for CCT8
     GenScript Custom overexpressing Cell Line Services for CCT8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCT8 promoter
     Search Chromatin IP Primers for CCT8
     RT2 qPCR Primer Assay in human, mouse, rat CCT8
     Search GNC Networks for CCT8
     SABiosciences PCR Arrays including human, mouse, rat CCT8
     Search Tocris compounds for CCT8
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for CCT8
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCT8 antibodies
     CCT8 proteins
     CCT8 lysates
     Antibodies for CCT8
     See all of Abcam's Antibodies, Kits and Proteins for CCT8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CCT8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CCT8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CCT8
     SwitchGear Promoter luciferase reporter plasmids for CCT8
     ThermoFisher Antibody for CCT8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CCT8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4