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Aliases for CCT8 Gene

Aliases for CCT8 Gene

  • Chaperonin Containing TCP1, Subunit 8 (Theta) 2 3
  • Renal Carcinoma Antigen NY-REN-15 3 4
  • TCP-1-Theta 3 4
  • C21orf112 3 4
  • CCT-Theta 3 4
  • Cctq 3 4
  • Chromosome 21 Open Reading Frame 112 2
  • T-Complex Protein 1 Subunit Theta 3
  • KIAA0002 4
  • D21S246 3
  • PRED71 3

External Ids for CCT8 Gene

Previous Symbols for CCT8 Gene

  • C21orf112

Summaries for CCT8 Gene

Entrez Gene Summary for CCT8 Gene

  • This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

GeneCards Summary for CCT8 Gene

CCT8 (Chaperonin Containing TCP1, Subunit 8 (Theta)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot for CCT8 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8 Gene

Genomics for CCT8 Gene

Genomic Location for CCT8 Gene

Start:
29,055,805 bp from pter
End:
29,073,797 bp from pter
Size:
17,993 bases
Orientation:
Minus strand

Genomic View for CCT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8 Gene

Regulatory Elements for CCT8 Gene

Proteins for CCT8 Gene

  • Protein details for CCT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50990-TCPQ_HUMAN
    Recommended name:
    T-complex protein 1 subunit theta
    Protein Accession:
    P50990
    Secondary Accessions:
    • A6NN54
    • B4DEM7
    • B4DQH4
    • Q4VBP8

    Protein attributes for CCT8 Gene

    Size:
    548 amino acids
    Molecular mass:
    59621 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=BAA02792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT8 Gene

Proteomics data for CCT8 Gene at MOPED

Post-translational modifications for CCT8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7, Lys16, Lys20, Lys37, Lys54, Lys62, Lys152, Lys171, Lys225, Lys235, Lys254, Lys260, Lys270, Lys326, Lys400, Lys421, Lys440, Lys459, Lys466, Lys528, and Lys540

Other Protein References for CCT8 Gene

No data available for DME Specific Peptides for CCT8 Gene

Domains for CCT8 Gene

Gene Families for CCT8 Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

UniProtKB/Swiss-Prot:

TCPQ_HUMAN
Family:
  • Belongs to the TCP-1 chaperonin family.:
    • P50990
genes like me logo Genes that share domains with CCT8: view

Function for CCT8 Gene

Molecular function for CCT8 Gene

UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042623 ATPase activity, coupled TAS 7890169
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT8: view
genes like me logo Genes that share phenotypes with CCT8: view

miRNA for CCT8 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT8 Gene

Localization for CCT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT8 Gene COMPARTMENTS Subcellular localization image for CCT8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 20080638
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
genes like me logo Genes that share ontologies with CCT8: view

Pathways for CCT8 Gene

genes like me logo Genes that share pathways with CCT8: view

Gene Ontology (GO) - Biological Process for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0046931 pore complex assembly IEA --
genes like me logo Genes that share ontologies with CCT8: view

Transcripts for CCT8 Gene

Unigene Clusters for CCT8 Gene

Chaperonin containing TCP1, subunit 8 (theta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - -
SP6: -
SP7:
SP8: - - -
SP9: -
SP10: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CCT8 Gene

GeneLoc Exon Structure for
CCT8
ECgene alternative splicing isoforms for
CCT8

Expression for CCT8 Gene

mRNA expression in normal human tissues for CCT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT8 Gene

SOURCE GeneReport for Unigene cluster for CCT8 Gene Hs.125113

genes like me logo Genes that share expressions with CCT8: view

Orthologs for CCT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT8 36
  • 99.7 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 95 (a)
OneToMany
CCT8 36
  • 93.73 (n)
  • 97.63 (a)
CCT8 37
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCT8 36
  • 93.13 (n)
  • 97.63 (a)
CCT8 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct8 36
  • 88.63 (n)
  • 96.9 (a)
Cct8 16
Cct8 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT8 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT8 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct8 36
  • 89.6 (n)
  • 96.9 (a)
chicken
(Gallus gallus)
Aves CCT8 36
  • 83.15 (n)
  • 93.42 (a)
CCT8 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT8 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cct8-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cct8 36
  • 76.39 (n)
  • 87.34 (a)
Str.7327 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9154 36
zebrafish
(Danio rerio)
Actinopterygii cct8 36
  • 75.95 (n)
  • 85.53 (a)
cct8 37
  • 86 (a)
OneToOne
zgc56059 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010588 36
  • 57.98 (n)
  • 64.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8258 36
  • 60.24 (n)
  • 62.73 (a)
CG8258 37
  • 61 (a)
OneToMany
CG8258 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-8 36
  • 59.53 (n)
  • 58.3 (a)
cct-8 37
  • 57 (a)
OneToMany
Y55F3AR.3 38
  • 52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR045W 36
  • 53.44 (n)
  • 47.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 36
  • 53.93 (n)
  • 47.53 (a)
CCT8 37
  • 45 (a)
OneToMany
CCT8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09350g 36
  • 53.86 (n)
  • 47.98 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03960 36
  • 55.96 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os.20293 36
Os03g0804800 36
  • 57.63 (n)
  • 54.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07567 36
  • 53.55 (n)
  • 51.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct8 36
  • 56.99 (n)
  • 51.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5094 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4432 37
  • 65 (a)
OneToOne
Species with no ortholog for CCT8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT8 Gene

ENSEMBL:
Gene Tree for CCT8 (if available)
TreeFam:
Gene Tree for CCT8 (if available)

Paralogs for CCT8 Gene

Paralogs for CCT8 Gene

Selected SIMAP similar genes for CCT8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT8 Gene

genes like me logo Genes that share paralogs with CCT8: view

Variants for CCT8 Gene

Sequence variations from dbSNP and Humsavar for CCT8 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs965951 -- 29,060,236(+) AGCTG(A/G)TGGTC intron-variant
rs1064019 -- 29,059,824(+) AAAGC(G/T)GAAAT intron-variant
rs2012645 -- 29,073,640(-) CGCTT(C/T)CTCCG utr-variant-5-prime
rs2070610 -- 29,073,627(-) GTCTT(C/T)CGAGC utr-variant-5-prime
rs2070611 -- 29,073,453(-) GCCTA(C/G)TAACG utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT8 Gene

Variant ID Type Subtype PubMed ID
nsv3485 CNV Loss 18451855

Relevant External Links for CCT8 Gene

HapMap Linkage Disequilibrium report
CCT8

Disorders for CCT8 Gene

No disorders were found for CCT8 Gene.

No data available for UniProtKB/Swiss-Prot for CCT8 Gene

Publications for CCT8 Gene

  1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PMID: 7890169) Kubota H. … Willison K. (Gene 1995) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21. (PMID: 8590283) Yamazaki M. … Nomura T. (DNA Res. 1995) 3 4
  4. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4

Products for CCT8 Gene

Sources for CCT8 Gene

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