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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT8 Gene

protein-coding   GIFtS: 64
GCID: GC21M030428

Chaperonin Containing TCP1, Subunit 8 (Theta)

(Previous name: chromosome 21 open reading frame 112)
(Previous symbol: C21orf112)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Chaperonin Containing TCP1, Subunit 8 (Theta)1 2     Cctq2
C21orf1121 2 3     D21S2462
Renal Carcinoma Antigen NY-REN-152 3     PRED712
CCT-theta2 3     T-Complex Protein 1 Subunit Theta2
TCP-1-theta2 3     CCTQ3
Chromosome 21 Open Reading Frame 1121     KIAA00023
T-Complex Protein 1, Theta Subunit11     

External Ids:    HGNC: 16231   Entrez Gene: 106942   Ensembl: ENSG000001562617   UniProtKB: P509903   

Export aliases for CCT8 gene to outside databases

Previous GC identifers: GC21M027007 GC21M029350 GC21M029349 GC21M015834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT8 Gene:
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be
involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple
transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. (provided by
RefSeq, Sep 2013)

GeneCards Summary for CCT8 Gene: 
CCT8 (chaperonin containing TCP1, subunit 8 (theta)) is a protein-coding gene. Diseases associated with CCT8 include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Formation of tubulin folding intermediates by CCT/TriC and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT8 gene promoter:
         AhR   LCR-F1   AP-2gamma   Meis-1b   Arnt   POU2F1   POU2F1a   FOXJ2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT8 promoter sequence

   Search SABiosciences Chromatin IP Primers for CCT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q22.11
CCT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M030428:   GeneLoc Nature:405,311-319
Start:
30,428,126 bp from pter       16,006,583 bp from centromere
End:
30,446,118 bp from pter 16,022,451 bp from centromere
Size:
17,993 bases 15,869 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: D13627
genomic clones: P100J12 P79E4


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990 (See protein sequence)
Recommended Name: T-complex protein 1 subunit theta  
Size: 548 amino acids; 59621 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Sequence caution: Sequence=BAA02792.2; Type=Erroneous initiation;
Secondary accessions: A6NN54 Q4VBP8

Explore the universe of human proteins at neXtProt for CCT8: NX_P50990

Explore proteomics data for CCT8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50990

  • CCT8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCT8 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269836.1  NP_001269837.1  NP_001269838.1  NP_006576.2  

    ENSEMBL proteins: 
     ENSP00000407748   ENSP00000286788   ENSP00000416832   ENSP00000444984   ENSP00000442730  
    Reactome Protein details: P50990
    Human Recombinant Protein Products for CCT8: 
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    Novus Biologicals CCT8 Protein
    Novus Biologicals CCT8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT8 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    CCT8 for ontologies           About GeneDecksing



    CCT8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHAP: Heat Shock Proteins / Chaperonins

    5/7 InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR012721 Chap_CCT_theta

    Graphical View of Domain Structure for InterPro Entry P50990

    ProtoNet protein and cluster: P50990

    1 Blocks protein domain: IPB002194 Chaperonin TCP-1

    UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPQ_HUMAN, P50990
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0042623ATPase activity, coupled TAS7890169
    GO:0051082unfolded protein binding IEA--
         
    CCT8 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CCT8:
     Cell division defect  Increased S DNA content, incre  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCT8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT8 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT8:
    hsa-miR-570
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    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of CCT8 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCT8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of tubulin folding intermediates by CCT/TriC
    Formation of tubulin folding intermediates by CCT/TriC0.74
    Prefoldin mediated transfer of substrate to CCT/TriC0.70
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCT8
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT8
        Cell cycle Role of APC in cell cycle regulation


    5/8        Reactome Pathways for CCT8 (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1023 Interacting proteins for CCT8 (P509902, 3 ENSP000002867884) via UniProtKB, MINT, STRING, and/or I2D (see all 1023)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT8 (TCPQ)

    Search CenterWatch for drugs/clinical trials and news about CCT8 / TCPQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCT8 gene (4 alternative transcripts): 
    NM_001282907.1  NM_001282908.1  NM_001282909.1  NM_006585.3  

    Unigene Cluster for CCT8:

    Chaperonin containing TCP1, subunit 8 (theta)
    Hs.125113  [show with all ESTs]
    Unigene Representative Sequence: BC012584
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432178 ENST00000496121 ENST00000470450(uc002yna.3) ENST00000286788(uc002ynb.3 uc011acq.2)
    ENST00000480359 ENST00000475205 ENST00000431234 ENST00000484403 ENST00000481059
    ENST00000494296 ENST00000542732(uc011acp.2) ENST00000540844

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT8:
    hsa-miR-570
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    OriGene ORF clones in mouse, rat for CCT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT8 (NM_006585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8
    Sirion Biotech Customized lentivirus for stable overexpression of CCT8 
                         Customized lentivirus expression plasmids for stable overexpression of CCT8 
    Primer
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    OriGene qPCR primer pairs and template standards for CCT8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT8
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8

    Additional mRNA sequence: 

    AK222490.1 AK293705.1 AK298801.1 AK308063.1 BC005220.1 BC012584.1 BC035472.1 BC072001.1 
    BC095470.1 D13627.1 

    24/40 DOTS entries (see all 40):

    DT.447995  DT.100685150  DT.100685126  DT.40233228  DT.91915597  DT.100685139  DT.95094734  DT.95094776 
    DT.95094777  DT.100712494  DT.95094770  DT.75127819  DT.121142275  DT.40117402  DT.95094748  DT.100685148 
    DT.121142263  DT.86819476  DT.92461930  DT.97864568  DT.121142174  DT.121142262  DT.100685124  DT.100685145 

    24/839 AceView cDNA sequences (see all 839):

    AI192252 BP365386 CR612834 BG616760 BE167047 AW149885 AW028997 CA431361 
    BE793435 CD244651 BU629581 BG481497 AW327849 BQ711078 BQ961619 BC005220 
    AU143604 BQ937837 BF940268 BI093596 CN481122 BQ226564 CR617977 BQ070546 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                    -     -     -                                   -                                                                                       
    SP2:                                                                    -                                         -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                          -     -     -     -                       -                                                                                       

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CCT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT8 expression in normal human tissues (normalized intensities)      CCT8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAACCAG
    CCT8 Expression
    About this image


    CCT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   

    See CCT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT8

    SOURCE GeneReport for Unigene cluster: Hs.125113
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCT8: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT8 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct81 , 5 chaperonin containing Tcp1, subunit 8 (theta)1, 5 88.63(n)1
    96.9(a)1
      16 (49.57 cM)5
    124691  NM_009840.31  NP_033970.31 
     874833265 
    chicken
    (Gallus gallus)
    Aves CCT81 chaperonin containing TCP1, subunit 8 (theta) 83.15(n)
    93.42(a)
      418486  NM_001004389.1  NP_001004389.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT86
    Uncharacterized protein
    90(a)
    1 ↔ 1
    3(146563076-146577438)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct8-prov2 chaperonin containing TCP1, subunit 8 (theta) 77.09(n)    BC045040.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560592 similar to chaperonin containing TCP1, subunit 8 (theta) 77.17(n)   394037  BC050492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82581 , 3 chaperonin ATPase3
    CG82581
    62(a)3
    60.24(n)1
    62.73(a)1
      44F53
    358821  NM_136574.21  NP_610418.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AR.33
    cct-81
    Protein CCT-81 52(a)3
    59.47(n)1
    58.3(a)1
      IV(1087818-1093919)3
    1769281  NM_067634.31  NP_500035.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT8(YJL008C)4
    CCT81
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct8p1
    53.93(n)1
    47.53(a)1
      10(421663-419957)4
    8534471, 4  NP_012526.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G039601 TCP-1/cpn60 chaperonin family protein 55.83(n)
    51.43(a)
      819549  NM_111267.4  NP_566219.1 
    rice
    (Oryza sativa)
    Liliopsida Os.202932 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.42(n)    AK100651.1 


    ENSEMBL Gene Tree for CCT8 (if available)
    TreeFam Gene Tree for CCT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT8 gene
    CCT8L22  
    8 SIMAP similar genes for CCT8 using alignment to 6 protein entries:     TCPQ_HUMAN (see all proteins):
    CCT5    CCT8L1P    CCT4    CCT8L2    CCT3    CCT2
    CCT7    TCP1

    CCT8 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCT8
    PGOHUM00000259481 PGOHUM00000263271


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/473 SNPs in CCT8 are shown (see all 473)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873333171,2
    --30428169(+) ACTGAC/TTTAAT 1 -- ds50010--------
    rs2005178631,2
    C--30428173(+) ACTTA-/ATTTTGT 1 -- ds50010--------
    rs350242711,2
    C,F,H--30428218(+) TGTACT/CTTGCT 1 -- ds50015Minor allele frequency- C:0.02NS NA 798
    rs1388817521,2
    --30428238(+) GTCTTC/GAACAA 1 -- ds50010--------
    rs622223751,2
    C,F--30428345(+) CCTGTA/GGAGGG 1 -- ds50012Minor allele frequency- G:0.07NA 122
    rs760021841,2
    F--30428356(+) CCAGAT/GAGTAA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1433538101,2
    --30428546(+) CTTACA/GTAAGT 1 -- ds50010--------
    rs1475344721,2
    --30428579(+) TAATGA/TGATTA 1 -- ds50010--------
    rs1917126671,2
    --30428587(+) TTAACA/GAGGTT 1 -- ds50010--------
    rs1835648021,2
    --30428671(+) TTATTA/GTAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCT8 (30428126 - 30446118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCT8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3485CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CCT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for CCT8:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    renal cell carcinoma    tuberculosis


    CCT8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CCT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT8 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with CCT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PubMed id 7890169)1, 2, 3, 9 Kubota H.... Willison K. (1995)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    8. Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21. (PubMed id 8590283)1, 2 Yamazaki M.... Nomura T. (1995)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    10. The novel ubiquitin ligase complex, SCF(Fbxw4), intera cts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10694 HGNC: 1623 AceView: CCT8 Ensembl:ENSG00000156261 euGenes: HUgn10694
    ECgene: CCT8 H-InvDB: CCT8

    (According to HUGE)
    About This Section
    HUGE: KIAA0002

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCT8 gene:
    Search GeneIP for patents involving CCT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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