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CCT8 Gene

protein-coding   GIFtS: 65
GCID: GC21M030428

Chaperonin Containing TCP1, Subunit 8 (Theta)

(Previous name: chromosome 21 open reading frame 112)
(Previous symbol: C21orf112)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Chaperonin Containing TCP1, Subunit 8 (Theta)1 2     Cctq2
C21orf1121 2 3     D21S2462
Renal Carcinoma Antigen NY-REN-152 3     PRED712
CCT-theta2 3     T-Complex Protein 1 Subunit Theta2
TCP-1-theta2 3     CCTQ3
Chromosome 21 Open Reading Frame 1121     KIAA00023
T-Complex Protein 1, Theta Subunit11     

External Ids:    HGNC: 16231   Entrez Gene: 106942   Ensembl: ENSG000001562617   UniProtKB: P509903   

Export aliases for CCT8 gene to outside databases

Previous GC identifers: GC21M027007 GC21M029350 GC21M029349 GC21M015834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT8 Gene:
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be
involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple
transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. (provided by
RefSeq, Sep 2013)

GeneCards Summary for CCT8 Gene:
CCT8 (chaperonin containing TCP1, subunit 8 (theta)) is a protein-coding gene. Diseases associated with CCT8 include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT8 gene promoter:
         AhR   LCR-F1   AP-2gamma   Meis-1b   Arnt   POU2F1   POU2F1a   FOXJ2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT8 promoter sequence

   Search Chromatin IP Primers for CCT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.3
Nature(405: 311-319) cytogenetic band:   21q22.11
CCT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT8 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M030428:   GeneLoc Nature:405,311-319
Start:
30,428,126 bp from pter       16,006,583 bp from centromere
End:
30,446,118 bp from pter 16,022,451 bp from centromere
Size:
17,993 bases 15,869 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: D13627
genomic clones: P100J12 P79E4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990 (See protein sequence)
Recommended Name: T-complex protein 1 subunit theta  
Size: 548 amino acids; 59621 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity)
Sequence caution: Sequence=BAA02792.2; Type=Erroneous initiation;
Secondary accessions: A6NN54 Q4VBP8

Explore the universe of human proteins at neXtProt for CCT8: NX_P50990

Explore proteomics data for CCT8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys16, Lys20, Lys37, Lys54, Lys62, Lys152, Lys171, Lys225, Lys235,
                                 Lys254, Lys260, Lys270, Lys326, Lys400, Lys421, Lys440, Lys459, Lys466, Lys528 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See CCT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269836.1  NP_001269837.1  NP_001269838.1  NP_006576.2  

    ENSEMBL proteins: 
     ENSP00000407748   ENSP00000286788   ENSP00000416832   ENSP00000444984   ENSP00000442730  
    Reactome Protein details: P50990

    CCT8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CCT8
    OriGene Protein Over-expression Lysate for CCT8
    OriGene MassSpec for CCT8
    OriGene Custom Protein Services for CCT8
    GenScript Custom Purified and Recombinant Proteins Services for CCT8
    Novus Biologicals CCT8 Protein
    Novus Biologicals CCT8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT8

    CCT8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CCT8
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    Novus Biologicals CCT8 Antibodies
    Abcam antibodies for CCT8
    Cloud-Clone Corp. Antibodies for CCT8
    ThermoFisher Antibody for CCT8
    LSBio Antibodies in human, mouse, rat for CCT8

    CCT8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCT8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCT8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT8
    Cloud-Clone Corp. CLIAs for CCT8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR012721 Chap_CCT_theta

    Graphical View of Domain Structure for InterPro Entry P50990

    ProtoNet protein and cluster: P50990

    1 Blocks protein domain: IPB002194 Chaperonin TCP-1

    UniProtKB/Swiss-Prot: TCPQ_HUMAN, P50990
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPQ_HUMAN, P50990
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0042623ATPase activity, coupled TAS7890169
    GO:0051082unfolded protein binding IEA--
         
    CCT8 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CCT8:
     Cell division defect  Increased S DNA content, incre  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT8:
    hsa-mir-301a-3p (MIRT044212), hsa-mir-615-3p (MIRT039814), hsa-mir-16-5p (MIRT051139), hsa-mir-93-5p (MIRT048794)

    Block miRNA regulation of human, mouse, rat CCT8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT8:
    hsa-miR-570
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT8
    Predesigned siRNA for gene silencing in human, mouse, rat CCT8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT8

    Clone
    Products:
         
    OriGene clones in human, mouse for CCT8 (see all 6)
    OriGene ORF clones in mouse, rat for CCT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT8 (NM_006585)
    Sino Biological Human cDNA Clone for CCT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCT8
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPQ_HUMAN, P50990: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    CCT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT8 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT8
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT8
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC



    CCT8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT8: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT8 (P509902, 3 ENSP000002867884) via UniProtKB, MINT, STRING, and/or I2D (see all 1097)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process TAS7890169
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT8 (TCPQ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCT8 gene (4 alternative transcripts): 
    NM_001282907.1  NM_001282908.1  NM_001282909.1  NM_006585.3  

    Unigene Cluster for CCT8:

    Chaperonin containing TCP1, subunit 8 (theta)
    Hs.125113  [show with all ESTs]
    Unigene Representative Sequence: BC012584
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432178 ENST00000496121 ENST00000470450(uc002yna.3) ENST00000286788(uc002ynb.3 uc011acq.2)
    ENST00000480359 ENST00000475205 ENST00000431234 ENST00000484403 ENST00000481059
    ENST00000494296 ENST00000542732(uc011acp.2) ENST00000540844
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCT8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT8:
    hsa-miR-570
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCT8
    Predesigned siRNA for gene silencing in human, mouse, rat CCT8
    Clone
    Products:
         
    OriGene clones in human, mouse for CCT8 (see all 6)
    OriGene ORF clones in mouse, rat for CCT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT8 (NM_006585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCT8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT8
      QuantiTect SYBR Green Assays in human, mouse, rat CCT8
      QuantiFast Probe-based Assays in human, mouse, rat CCT8

    Additional mRNA sequence: 

    AK222490.1 AK293705.1 AK298801.1 AK308063.1 BC005220.1 BC012584.1 BC035472.1 BC072001.1 
    BC095470.1 D13627.1 

    Selected DOTS entries (see all 40):

    DT.447995  DT.100685150  DT.100685126  DT.40233228  DT.91915597  DT.100685139  DT.95094734  DT.95094776 
    DT.95094777  DT.100712494  DT.95094770  DT.75127819  DT.121142275  DT.40117402  DT.95094748  DT.100685148 
    DT.121142263  DT.86819476  DT.92461930  DT.97864568  DT.121142174  DT.121142262  DT.100685124  DT.100685145 

    Selected AceView cDNA sequences (see all 839):

    CB157935 CD358415 BE898872 BQ920645 BE795851 CR600309 AW009227 AW028997 
    BE265421 BI836695 CA942949 BE785658 AW518890 AI351988 BI497358 BE268108 
    BP373577 BQ897583 AI192252 AI093270 CR619682 CR590648 BM475596 BE884282 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                    -     -     -                                   -                                                                                       
    SP2:                                                                    -                                         -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                          -     -     -     -                       -                                                                                       

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CCT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAACCAG
    CCT8 Expression
    About this image


    CCT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CCT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125113
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT8: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCT8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT8
    QuantiTect SYBR Green Assays in human, mouse, rat CCT8
    QuantiFast Probe-based Assays in human, mouse, rat CCT8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT8 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct81 , 5 chaperonin containing Tcp1, subunit 8 (theta)1, 5 88.63(n)1
    96.9(a)1
      16 (49.57 cM)5
    124691  NM_009840.31  NP_033970.31 
     874833265 
    chicken
    (Gallus gallus)
    Aves CCT81 chaperonin containing TCP1, subunit 8 (theta) 83.15(n)
    93.42(a)
      418486  NM_001004389.1  NP_001004389.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT86
    chaperonin containing TCP1, subunit 8 (theta)
    90(a)
    1 ↔ 1
    3(146563076-146577438)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct8-prov2 chaperonin containing TCP1, subunit 8 (theta) 77.09(n)    BC045040.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560592 similar to chaperonin containing TCP1, subunit 8 (theta) 77.17(n)   394037  BC050492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82581 , 3 chaperonin ATPase3
    CG82581
    62(a)3
    60.24(n)1
    62.73(a)1
      44F53
    358821  NM_136574.21  NP_610418.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AR.33
    cct-81
    cct-81 52(a)3
    59.53(n)1
    58.3(a)1
      IV(1087818-1093919)3
    1769281  NM_067634.41  NP_500035.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT8(YJL008C)4
    CCT81
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    CCT81
    53.93(n)1
    47.53(a)1
      10(421663-419957)4
    8534471, 4  NP_012526.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G039601 AT3G03960 55.96(n)
    51.43(a)
      819549  NM_111267.4  NP_566219.1 
    rice
    (Oryza sativa)
    Liliopsida Os.202932 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.42(n)    AK100651.1 


    ENSEMBL Gene Tree for CCT8 (if available)
    TreeFam Gene Tree for CCT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT8 gene
    CCT8L22  
    8 SIMAP similar genes for CCT8 using alignment to 6 protein entries:     TCPQ_HUMAN (see all proteins):
    CCT5    CCT8L1P    CCT4    CCT8L2    CCT3    CCT2
    CCT7    TCP1

    CCT8 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCT8
    PGOHUM00000259481 PGOHUM00000263271


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT8 (see all 473)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873333171,2
    --30428169(+) ACTGAC/TTTAAT 1 -- ds50010--------
    rs2005178631,2
    C--30428173(+) ACTTA-/ATTTTGT 1 -- ds50010--------
    rs350242711,2
    C,F,H--30428218(+) TGTACT/CTTGCT 1 -- ds50015Minor allele frequency- C:0.02NS NA 798
    rs1388817521,2
    --30428238(+) GTCTTC/GAACAA 1 -- ds50010--------
    rs622223751,2
    C,F--30428345(+) CCTGTA/GGAGGG 1 -- ds50012Minor allele frequency- G:0.07NA 122
    rs760021841,2
    F--30428356(+) CCAGAT/GAGTAA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1433538101,2
    --30428546(+) CTTACA/GTAAGT 1 -- ds50010--------
    rs1475344721,2
    --30428579(+) TAATGA/TGATTA 1 -- ds50010--------
    rs1917126671,2
    --30428587(+) TTAACA/GAGGTT 1 -- ds50010--------
    rs1835648021,2
    --30428671(+) TTATTA/GTAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCT8 (30428126 - 30446118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3485CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT8
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    11 diseases for CCT8:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    renal cell carcinoma    tuberculosis    tonsillitis    thyroiditis
    prostatitis    malaria    endotheliitis


    CCT8 for disorders           About GeneDecksing


    Export disorders for CCT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT8 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with CCT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PubMed id 7890169)1, 2, 3, 9 Kubota H.... Willison K. (Gene 1995)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    8. Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21. (PubMed id 8590283)1, 2 Yamazaki M.... Nomura T. (DNA Res. 1995)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10694 HGNC: 1623 AceView: CCT8 Ensembl:ENSG00000156261 euGenes: HUgn10694
    ECgene: CCT8 H-InvDB: CCT8

    (According to HUGE)
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    HUGE: KIAA0002

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCT8 gene:
    Search GeneIP for patents involving CCT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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