Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCT8 Gene

Aliases for CCT8 Gene

  • Chaperonin Containing TCP1 Subunit 8 2 3
  • Chaperonin Containing TCP1, Subunit 8 (Theta) 2 3 5
  • Renal Carcinoma Antigen NY-REN-15 3 4
  • TCP-1-Theta 3 4
  • C21orf112 3 4
  • CCT-Theta 3 4
  • Cctq 3 4
  • Chromosome 21 Open Reading Frame 112 2
  • KIAA0002 4
  • D21S246 3
  • PRED71 3

External Ids for CCT8 Gene

Previous HGNC Symbols for CCT8 Gene

  • C21orf112

Previous GeneCards Identifiers for CCT8 Gene

  • GC21M027007
  • GC21M029350
  • GC21M029349
  • GC21M030428
  • GC21M015834

Summaries for CCT8 Gene

Entrez Gene Summary for CCT8 Gene

  • This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

GeneCards Summary for CCT8 Gene

CCT8 (Chaperonin Containing TCP1 Subunit 8) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and G-protein activation. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is CCT8L2.

UniProtKB/Swiss-Prot for CCT8 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT8 Gene

Genomics for CCT8 Gene

Regulatory Elements for CCT8 Gene

Enhancers for CCT8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCT8 on UCSC Golden Path with GeneCards custom track

Promoters for CCT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT8 Gene

Chromosome:
21
Start:
29,055,805 bp from pter
End:
29,073,797 bp from pter
Size:
17,993 bases
Orientation:
Minus strand

Genomic View for CCT8 Gene

Genes around CCT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT8 Gene

Proteins for CCT8 Gene

  • Protein details for CCT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50990-TCPQ_HUMAN
    Recommended name:
    T-complex protein 1 subunit theta
    Protein Accession:
    P50990
    Secondary Accessions:
    • A6NN54
    • B4DEM7
    • B4DQH4
    • Q4VBP8

    Protein attributes for CCT8 Gene

    Size:
    548 amino acids
    Molecular mass:
    59621 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=BAA02792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT8 Gene

Proteomics data for CCT8 Gene at MOPED

Post-translational modifications for CCT8 Gene

  • Ubiquitination at Lys 7, Lys 37, Lys 54, Lys 62, Lys 152, Lys 171, Lys 225, Lys 235, Lys 254, Lys 260, Lys 421, Lys 440, Lys 459, Lys 466, Lys 528, and Lys 540
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT8 Gene

Domains & Families for CCT8 Gene

Gene Families for CCT8 Gene

Graphical View of Domain Structure for InterPro Entry

P50990

UniProtKB/Swiss-Prot:

TCPQ_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT8: view

Function for CCT8 Gene

Molecular function for CCT8 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with CCT8: view

Animal Model Products

miRNA for CCT8 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT8 Gene

Localization for CCT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT8 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT8 Gene COMPARTMENTS Subcellular localization image for CCT8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 20080638
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CCT8: view

Pathways & Interactions for CCT8 Gene

genes like me logo Genes that share pathways with CCT8: view

Gene Ontology (GO) - Biological Process for CCT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
GO:0046931 pore complex assembly IEA --
GO:0050821 protein stabilization IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT8: view

No data available for SIGNOR curated interactions for CCT8 Gene

Drugs & Compounds for CCT8 Gene

No Compound Related Data Available

Transcripts for CCT8 Gene

Unigene Clusters for CCT8 Gene

Chaperonin containing TCP1, subunit 8 (theta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - -
SP6: -
SP7:
SP8: - - -
SP9: -
SP10: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CCT8 Gene

GeneLoc Exon Structure for
CCT8
ECgene alternative splicing isoforms for
CCT8

Expression for CCT8 Gene

mRNA expression in normal human tissues for CCT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCT8 Gene

This gene is overexpressed in Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT8 Gene



SOURCE GeneReport for Unigene cluster for CCT8 Gene Hs.125113

genes like me logo Genes that share expression patterns with CCT8: view

Protein tissue co-expression partners for CCT8 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT8 Gene

Orthologs for CCT8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT8 35
  • 93.73 (n)
  • 97.63 (a)
-- 36
  • 95 (a)
OneToMany
CCT8 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCT8 35
  • 93.13 (n)
  • 97.63 (a)
CCT8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct8 35
  • 88.63 (n)
  • 96.9 (a)
Cct8 16
Cct8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT8 35
  • 99.7 (n)
  • 99.45 (a)
rat
(Rattus norvegicus)
Mammalia Cct8 35
  • 89.6 (n)
  • 96.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CCT8 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT8 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT8 35
  • 83.15 (n)
  • 93.42 (a)
CCT8 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT8 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct8 35
  • 76.39 (n)
  • 87.34 (a)
Str.7327 35
African clawed frog
(Xenopus laevis)
Amphibia cct8-prov 35
zebrafish
(Danio rerio)
Actinopterygii cct8 35
  • 75.95 (n)
  • 85.53 (a)
zgc56059 35
cct8 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9154 35
fruit fly
(Drosophila melanogaster)
Insecta CG8258 37
  • 62 (a)
CG8258 35
  • 60.24 (n)
  • 62.73 (a)
CG8258 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010588 35
  • 57.98 (n)
  • 64.04 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AR.3 37
  • 52 (a)
cct-8 35
  • 59.53 (n)
  • 58.3 (a)
cct-8 36
  • 57 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR045W 35
  • 53.44 (n)
  • 47.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09350g 35
  • 53.86 (n)
  • 47.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT8 35
  • 53.93 (n)
  • 47.53 (a)
CCT8 36
  • 45 (a)
OneToMany
CCT8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03960 35
  • 55.96 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os.20293 35
Os03g0804800 35
  • 57.63 (n)
  • 54.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5094 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07567 35
  • 53.55 (n)
  • 51.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct8 35
  • 56.99 (n)
  • 51.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4432 36
  • 65 (a)
OneToOne
Species with no ortholog for CCT8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT8 Gene

ENSEMBL:
Gene Tree for CCT8 (if available)
TreeFam:
Gene Tree for CCT8 (if available)

Paralogs for CCT8 Gene

Paralogs for CCT8 Gene

(8) SIMAP similar genes for CCT8 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT8 Gene

genes like me logo Genes that share paralogs with CCT8: view

Variants for CCT8 Gene

Sequence variations from dbSNP and Humsavar for CCT8 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs16983693 - 29,073,579(+) GGAAC(G/T)TGAAG reference, missense, utr-variant-5-prime
rs8129954 - 29,061,555(+) GGGTA(A/C/T)AAGAC reference, missense
rs2515640 -- 29,065,800(-) cagcG(C/G)AAAAT intron-variant
rs2692625 -- 29,074,039(+) CAGAG(C/G)ATCTG upstream-variant-2KB
rs2776257 -- 29,071,436(+) ggagt(G/T)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT8 Gene

Variant ID Type Subtype PubMed ID
nsv3485 CNV Loss 18451855

Variation tolerance for CCT8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCT8 Gene

Disorders for CCT8 Gene

Relevant External Links for CCT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT8

No disorders were found for CCT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT8 Gene

Publications for CCT8 Gene

  1. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. (PMID: 7890169) Kubota H. … Willison K. (Gene 1995) 2 3 4 23 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3

Products for CCT8 Gene

Sources for CCT8 Gene

Content