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Aliases for CCT7 Gene

Aliases for CCT7 Gene

  • Chaperonin Containing TCP1 Subunit 7 2 3 5
  • HIV-1 Nef-Interacting Protein 3 4
  • TCP-1-Eta 3 4
  • CCT-Eta 3 4
  • NIP7-1 3 4
  • CCTH 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit 3
  • Chaperonin Containing TCP1, Subunit 7 (Eta) 2
  • T-Complex Protein 1 Subunit Eta 3
  • HIV-1 Nef Interacting Protein 3
  • TCP1ETA 3
  • CCTETA 3

External Ids for CCT7 Gene

Previous GeneCards Identifiers for CCT7 Gene

  • GC02P073470
  • GC02P073672
  • GC02P073419
  • GC02P073435
  • GC02P073373
  • GC02P073314
  • GC02P073460
  • GC02P073197

Summaries for CCT7 Gene

Entrez Gene Summary for CCT7 Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

GeneCards Summary for CCT7 Gene

CCT7 (Chaperonin Containing TCP1 Subunit 7) is a Protein Coding gene. Diseases associated with CCT7 include Babesiosis and Dupuytren Contracture. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Transport to the Golgi and subsequent modification. GO annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT7 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT7 Gene

Genomics for CCT7 Gene

Regulatory Elements for CCT7 Gene

Enhancers for CCT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CCT7 on UCSC Golden Path with GeneCards custom track

Promoters for CCT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CCT7 Gene

Chromosome:
2
Start:
73,233,420 bp from pter
End:
73,253,022 bp from pter
Size:
19,603 bases
Orientation:
Plus strand

Genomic View for CCT7 Gene

Genes around CCT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT7 Gene

Proteins for CCT7 Gene

  • Protein details for CCT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99832-TCPH_HUMAN
    Recommended name:
    T-complex protein 1 subunit eta
    Protein Accession:
    Q99832
    Secondary Accessions:
    • A8K7E6
    • A8MWI8
    • B7WNW9
    • B7Z4T9
    • B7Z4Z7
    • O14871
    • Q6FI26

    Protein attributes for CCT7 Gene

    Size:
    543 amino acids
    Molecular mass:
    59367 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.

    Alternative splice isoforms for CCT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT7 Gene

Post-translational modifications for CCT7 Gene

  • Ubiquitination at Lys 47, Lys 55, Lys 77, Lys 84, Lys 109, Lys 135, Lys 166, Lys 172, Lys 218, Lys 277, Lys 368, Lys 418, Lys 430, Lys 440, and Lys 521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT7 Gene

Domains & Families for CCT7 Gene

Gene Families for CCT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99832

UniProtKB/Swiss-Prot:

TCPH_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT7: view

Function for CCT7 Gene

Molecular function for CCT7 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Ontology (GO) - Molecular Function for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042802 identical protein binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT7: view
genes like me logo Genes that share phenotypes with CCT7: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT7 Gene

Localization for CCT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT7 Gene COMPARTMENTS Subcellular localization image for CCT7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm TAS 9819444
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex TAS 25467444
genes like me logo Genes that share ontologies with CCT7: view

Pathways & Interactions for CCT7 Gene

genes like me logo Genes that share pathways with CCT7: view

Gene Ontology (GO) - Biological Process for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0050821 protein stabilization IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT7: view

No data available for SIGNOR curated interactions for CCT7 Gene

Drugs & Compounds for CCT7 Gene

No Compound Related Data Available

Transcripts for CCT7 Gene

Unigene Clusters for CCT7 Gene

Chaperonin containing TCP1, subunit 7 (eta):
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - -
SP14:
SP15:

ExUns: 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:

Relevant External Links for CCT7 Gene

GeneLoc Exon Structure for
CCT7
ECgene alternative splicing isoforms for
CCT7

Expression for CCT7 Gene

mRNA expression in normal human tissues for CCT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT7 Gene



Protein tissue co-expression partners for CCT7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT7 Gene:

CCT7

SOURCE GeneReport for Unigene cluster for CCT7 Gene:

Hs.368149
genes like me logo Genes that share expression patterns with CCT7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT7 Gene

Orthologs for CCT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT7 34
  • 91.22 (n)
  • 98.16 (a)
CCT7 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct7 34
  • 89.87 (n)
  • 96.98 (a)
Cct7 16
Cct7 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT7 34
  • 99.69 (n)
  • 100 (a)
CCT7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct7 34
  • 90.43 (n)
  • 97 (a)
dog
(Canis familiaris)
Mammalia CCT7 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT7 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT7 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT7 34
  • 81.51 (n)
  • 94.53 (a)
CCT7 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT7 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct7 34
  • 79.8 (n)
  • 90.43 (a)
Str.2286 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6672 34
zebrafish
(Danio rerio)
Actinopterygii cct7 34
  • 78.74 (n)
  • 88.18 (a)
cct7 35
  • 88 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12021 34
fruit fly
(Drosophila melanogaster)
Insecta CG8351 36
  • 76 (a)
Tcp-1eta 34
  • 69.78 (n)
  • 76.53 (a)
Tcp-1eta 35
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002762 34
  • 69.66 (n)
  • 77.67 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-7 34
  • 62.97 (n)
  • 65.39 (a)
cct-7 35
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR067W 34
  • 63.97 (n)
  • 65.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21340g 34
  • 61.54 (n)
  • 65.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT7 34
  • 61.04 (n)
  • 64.3 (a)
CCT7 35
  • 62 (a)
OneToOne
CCT7 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11830 34
  • 63.56 (n)
  • 68.57 (a)
soybean
(Glycine max)
eudicotyledons Gma.8037 34
barley
(Hordeum vulgare)
Liliopsida Hv.3076 34
rice
(Oryza sativa)
Liliopsida Os.11699 34
Os06g0687700 34
  • 63.24 (n)
  • 69.2 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14018 34
corn
(Zea mays)
Liliopsida Zm.3176 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4924 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09700 34
  • 63.1 (n)
  • 64.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct7 34
  • 62.32 (n)
  • 66.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5206 35
  • 79 (a)
OneToOne
Species where no ortholog for CCT7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT7 Gene

ENSEMBL:
Gene Tree for CCT7 (if available)
TreeFam:
Gene Tree for CCT7 (if available)

Paralogs for CCT7 Gene

(8) SIMAP similar genes for CCT7 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT7 Gene

genes like me logo Genes that share paralogs with CCT7: view

No data available for Paralogs for CCT7 Gene

Variants for CCT7 Gene

Sequence variations from dbSNP and Humsavar for CCT7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2231427 - 73,247,918(+) TCCAC(A/G)CAGTT nc-transcript-variant, reference, missense
rs1053631 -- 73,252,961(+) GGCCC(A/C)CTCTC nc-transcript-variant, utr-variant-3-prime
rs1246167 -- 73,242,480(+) tcacc(A/G)tgttg intron-variant
rs1246168 -- 73,248,305(+) CTCTG(A/G)AGGTA intron-variant
rs1367292 -- 73,248,302(+) TACCT(C/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT7 Gene

Variant ID Type Subtype PubMed ID
esv3583864 CNV loss 25503493
nsv2776 CNV deletion 18451855

Variation tolerance for CCT7 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT7 Gene

Human Gene Mutation Database (HGMD)
CCT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT7 Gene

Disorders for CCT7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCT7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
babesiosis
  • babesiasis
dupuytren contracture
  • contraction of palmar fascia
- elite association - COSMIC cancer census association via MalaCards
Search CCT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT7

Genetic Association Database (GAD)
CCT7
Human Genome Epidemiology (HuGE) Navigator
CCT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT7
genes like me logo Genes that share disorders with CCT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT7 Gene

Publications for CCT7 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4 65
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4 65

Products for CCT7 Gene

Sources for CCT7 Gene

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