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CCT7 Gene

protein-coding   GIFtS: 67
GCID: GC02P073460

Chaperonin Containing TCP1, Subunit 7 (Eta)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 7 (Eta)1 2     CCTETA2
CCT-eta2 3     TCP1ETA2
CCTH2 3     Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit2
NIP7-12 3     HIV-1 Nef Interacting Protein2
TCP-1-eta2 3     T-Complex Protein 1 Subunit Eta2
HIV-1 Nef-Interacting Protein2 3     

External Ids:    HGNC: 16221   Entrez Gene: 105742   Ensembl: ENSG000001356247   OMIM: 6051405   UniProtKB: Q998323   

Export aliases for CCT7 gene to outside databases

Previous GC identifers: GC02P073470 GC02P073672 GC02P073419 GC02P073435 GC02P073373 GC02P073314 GC02P073197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT7 Gene:
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also
known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing
eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an
ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing
results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6.
(provided by RefSeq, Oct 2009)

GeneCards Summary for CCT7 Gene:
CCT7 (chaperonin containing TCP1, subunit 7 (eta)) is a protein-coding gene. Diseases associated with CCT7 include babesiosis, and hiv-1. GO annotations related to this gene include unfolded protein binding and identical protein binding.

UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
vitro, in the folding of actin and tubulin (By similarity)

Gene Wiki entry for CCT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT7 gene promoter:
         Pax-5   HOXA3   NF-kappaB   NF-AT   CREB   NF-AT4   NF-AT2   NF-AT3   NF-kappaB1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCT7 promoter sequence
   Search Chromatin IP Primers for CCT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.2   Ensembl cytogenetic band:  2p13.2   HGNC cytogenetic band: 2p13.2

CCT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P073460:  view genomic region     (about GC identifiers)

Start:
73,460,548 bp from pter      End:
73,480,150 bp from pter
Size:
19,603 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCT7

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832 (See protein sequence)
Recommended Name: T-complex protein 1 subunit eta  
Size: 543 amino acids; 59367 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG
Secondary accessions: A8K7E6 A8MWI8 B7WNW9 B7Z4T9 B7Z4Z7 O14871 Q6FI26
Alternative splicing: 4 isoforms:  Q99832-1   Q99832-2   Q99832-3   Q99832-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT7: NX_Q99832

Explore proteomics data for CCT7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys55, Lys67, Lys77, Lys84, Lys109, Lys135, Lys166, Lys172, Lys218,
                                 Lys277, Lys292, Lys368, Lys418, Lys430, Lys440, Lys463, Lys521
  • Modification sites at PhosphoSitePlus

  • See CCT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001009570.1  NP_001159756.1  NP_001159757.1  NP_006420.1  

    ENSEMBL proteins: 
     ENSP00000258091   ENSP00000412996   ENSP00000381456   ENSP00000386978   ENSP00000442058  
     ENSP00000437824   ENSP00000444379   ENSP00000438462  
    Reactome Protein details: Q99832

    CCT7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCT7
    OriGene Protein Over-expression Lysate for CCT7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCT7
    GenScript Custom Purified and Recombinant Proteins Services for CCT7
    Novus Biologicals CCT7 Proteins
    Novus Biologicals CCT7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT7

    CCT7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CCT7
    OriGene Custom Antibody Services for CCT7
    Novus Biologicals CCT7 Antibodies
    Abcam antibodies for CCT7
    Cloud-Clone Corp. Antibodies for CCT7
    ThermoFisher Antibodies for CCT7
    LSBio Antibodies in human, mouse, rat for CCT7

    CCT7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCT7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCT7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT7
    Cloud-Clone Corp. CLIAs for CCT7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR012720 Chap_CCT_eta
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry Q99832

    ProtoNet protein and cluster: Q99832

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPH_HUMAN, Q99832
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
    vitro, in the folding of actin and tubulin (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0042802identical protein binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    CCT7 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CCT7:
     Cell division defect  Decreased POU5F1-GFP protein e  Decreased TP53 protein express  Decreased viability of wild-ty 
     Increased S DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT7:
    hsa-mir-598-3p (MIRT040484), hsa-mir-26b-5p (MIRT030121), hsa-mir-615-3p (MIRT040174), hsa-mir-505-3p (MIRT041059), hsa-mir-92a-3p (MIRT049820), hsa-mir-23b-3p (MIRT046278), hsa-mir-1260b (MIRT052763), hsa-mir-877-3p (MIRT036986)

    Block miRNA regulation of human, mouse, rat CCT7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT7:
    hsa-miR-502-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCT7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT7
    Predesigned siRNA for gene silencing in human, mouse, rat CCT7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT7

    Clone
    Products:
         
    OriGene clones in human, mouse for CCT7 (see all 22)
    OriGene ORF clones in mouse, rat for CCT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCT7 (NM_006429)
    Sino Biological Human cDNA Clone for CCT7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCT7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPH_HUMAN, Q99832: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm TAS9819444
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    CCT7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT7
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT7
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC



    CCT7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT7: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT7 (Q998322, 3 ENSP000002580914) via UniProtKB, MINT, STRING, and/or I2D (see all 1065)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=5 STRING: ENSP00000317334
    CCT4P509912, 3, ENSP000003779584MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000377958
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=1 STRING: ENSP00000357244
    DNM2P505702, 3MINT-7945693 MINT-8254382 MINT-7947479 I2D: score=2 
    ENSG00000258947Q135092, 3MINT-7945693 MINT-8415355 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT7 (TCPH)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCT7 gene (4 alternative transcripts): 
    NM_001009570.2  NM_001166284.1  NM_001166285.1  NM_006429.3  

    Unigene Cluster for CCT7:

    Chaperonin containing TCP1, subunit 7 (eta)
    Hs.368149  [show with all ESTs]
    Unigene Representative Sequence: NM_001166285
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471927 ENST00000469844 ENST00000473197 ENST00000492253 ENST00000258091
    ENST00000461290 ENST00000464397 ENST00000399032 ENST00000398422 ENST00000480489
    ENST00000409924 ENST00000473786 ENST00000482064 ENST00000488856 ENST00000540468(uc010yri.2 uc002sja.3)
    ENST00000539919(uc010yrf.2 uc002siz.3 uc010yrh.2 uc010yrg.2)
    ENST00000537131 ENST00000538797
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCT7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT7:
    hsa-miR-502-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCT7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCT7
    Predesigned siRNA for gene silencing in human, mouse, rat CCT7
    Clone
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    OriGene clones in human, mouse for CCT7 (see all 22)
    OriGene ORF clones in mouse, rat for CCT7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCT7 (NM_006429)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCT7
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT7
      QuantiTect SYBR Green Assays in human, mouse, rat CCT7
      QuantiFast Probe-based Assays in human, mouse, rat CCT7

    Additional mRNA sequence: 

    AF026292.1 AK098549.1 AK098825.1 AK222478.1 AK291961.1 AK293175.1 AK293597.1 AK297846.1 
    AK298153.1 AK302078.1 BC019296.1 BC088351.1 CR456719.1 CR536511.1 NR_029402.1 NR_029403.1 
    U83843.1 

    Selected DOTS entries (see all 47):

    DT.91776362  DT.452195  DT.100689500  DT.95152728  DT.100689507  DT.95152770  DT.100689497  DT.100689486 
    DT.100689490  DT.87017058  DT.100689493  DT.120971312  DT.120971369  DT.99980935  DT.100689472  DT.121383108 
    DT.95152722  DT.100689476  DT.120971368  DT.92050813  DT.100689474  DT.100689483  DT.120971325  DT.97868470 

    Selected AceView cDNA sequences (see all 1694):

    BM784126 BQ052758 CR602707 BQ690127 BQ690242 CR610859 AA745670 BM837903 
    BQ069867 BU850152 T33724 BQ220623 BQ684785 BM457794 CA393699 CB123702 
    BU552464 BM541381 BQ690862 CA844224 BU145360 BQ690120 BU859223 BE313330 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
    SP1:                          -                                   -                             -     -           -                                             
    SP2:                                                                                            -     -           -                                             
    SP3:                                                              -                             -     -           -                                             
    SP4:                          -                                   -                             -     -           -                 -                           
    SP5:                                                              -                             -     -           -                                             

    ExUns: 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for CCT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCT7 expression in normal human tissues (normalized intensities)      CCT7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCTGGC
    CCT7 Expression
    About this image


    CCT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CCT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368149
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT7: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCT7
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT7
    QuantiTect SYBR Green Assays in human, mouse, rat CCT7
    QuantiFast Probe-based Assays in human, mouse, rat CCT7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT7 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct71 , 5 chaperonin containing Tcp1, subunit 7 (eta)1, 5 89.87(n)1
    96.98(a)1
      6 (37.46 cM)5
    124681  NM_007638.41  NP_031664.31 
     854515055 
    chicken
    (Gallus gallus)
    Aves CCT71 chaperonin containing TCP1, subunit 7 (eta) 81.51(n)
    94.53(a)
      428806  NM_001031541.1  NP_001026712.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT76
    chaperonin containing TCP1, subunit 7 (eta)
    91(a)
    1 ↔ 1
    GL343815.1(33869-46690)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66722 Xenopus laevis, Similar to chaperonin subunit 7 (eta), more 80.32(n)    BC045074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct72 chaperonin containing TCP1, subunit 7 (eta) 79.94(n)   192324  AF506229.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83513
    Tcp-1eta1
    chaperonin ATPase3
    Tcp-1eta1
    76(a)3
    69.78(n)1
    76.53(a)1
      410541  NM_141578.21  NP_649835.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-71 cct-7 62.97(n)
    65.39(a)
      178670  NM_071121.4  NP_503522.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT7(YJL111W)4
    CCT71
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    CCT71
    61.04(n)1
    64.3(a)1
      10(207877-209529)4
    8533331, 4  NP_012424.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G118301 AT3G11830 63.56(n)
    68.57(a)
      820356  NM_112016.4  NP_187789.1 
    rice
    (Oryza sativa)
    Liliopsida Os.116992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.91(n)    AK109357.1 


    ENSEMBL Gene Tree for CCT7 (if available)
    TreeFam Gene Tree for CCT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT7 gene
    8 SIMAP similar genes for CCT7 using alignment to 6 protein entries:     TCPH_HUMAN (see all proteins):
    TCP1    CCT3    CCT5    CCT2    CCT4    CCT6B
    CCT8    CCT6A

    CCT7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCT7
    PGOHUM00000235311 PGOHUM00000243814


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT7 (see all 433)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143671691,2
    C,F--73462430(+) GGGCCA/GGCTTC 6 -- int11Minor allele frequency- G:0.02WA 118
    rs1915482131,2
    C--73462514(+) TCCGAC/TTCTAT 6 -- int10--------
    rs1394302681,2
    --73462516(+) CGACTC/GTATCT 6 -- int10--------
    rs1456551361,2
    --73462528(+) CTGCTC/TTTTTC 6 -- int10--------
    rs1836833351,2
    --73462569(+) AGGGAC/TGCAGA 6 -- int10--------
    rs1477355921,2
    --73462642(+) TTAGCA/GTTTAA 6 -- int10--------
    rs608782681,2
    C--73462753(+) CCTCTA/GGAGCT 6 -- int1 ut510--------
    rs1441743941,2
    --73462762(+) CTACAC/GTGAAT 6 -- int1 ut510--------
    rs1895286681,2
    --73462841(+) GTTCTC/TAGTTT 6 -- int10--------
    rs67147341,2
    C,F--73462880(+) tcagcA/Gatgtt 6 -- int16Minor allele frequency- G:0.19NA CSA WA 246

    HapMap Linkage Disequilibrium report for CCT7 (73460548 - 73480150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2776CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605140    OMIM disorders: --

    8 diseases for CCT7:    About MalaCards
    babesiosis    hiv-1    cerebral cavernous malformations 3    cavernous malformation
    cerebral cavernous malformation    cerebritis    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for CCT7:
    Babesiosis

    CCT7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCT7
    Human Genome Epidemiology (HuGE) Navigator: CCT7 (1 document)

    Export disorders for CCT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT7 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with CCT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PubMed id 9819444)1, 2, 3 Won K.-A.... Reed S.I. (Mol. Cell. Biol. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PubMed id 23277564)1 Delker R.K....Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10574 HGNC: 1622 AceView: CCT7 Ensembl:ENSG00000135624 euGenes: HUgn10574
    ECgene: CCT7 H-InvDB: CCT7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCT7 gene:
    Search GeneIP for patents involving CCT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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