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Aliases for CCT7 Gene

Aliases for CCT7 Gene

  • Chaperonin Containing TCP1, Subunit 7 (Eta) 2 3
  • HIV-1 Nef-Interacting Protein 3 4
  • TCP-1-Eta 3 4
  • CCT-Eta 3 4
  • NIP7-1 3 4
  • CCTH 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit 3
  • T-Complex Protein 1 Subunit Eta 3
  • HIV-1 Nef Interacting Protein 3
  • TCP1ETA 3
  • CCTETA 3

External Ids for CCT7 Gene

Summaries for CCT7 Gene

Entrez Gene Summary for CCT7 Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

GeneCards Summary for CCT7 Gene

CCT7 (Chaperonin Containing TCP1, Subunit 7 (Eta)) is a Protein Coding gene. Diseases associated with CCT7 include myocardial infarction and hiv-1. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT7 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT7 Gene

Genomics for CCT7 Gene

Genomic Location for CCT7 Gene

Start:
73,233,420 bp from pter
End:
73,253,022 bp from pter
Size:
19,603 bases
Orientation:
Plus strand

Genomic View for CCT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT7 Gene

Regulatory Elements for CCT7 Gene

Proteins for CCT7 Gene

  • Protein details for CCT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99832-TCPH_HUMAN
    Recommended name:
    T-complex protein 1 subunit eta
    Protein Accession:
    Q99832
    Secondary Accessions:
    • A8K7E6
    • A8MWI8
    • B7WNW9
    • B7Z4T9
    • B7Z4Z7
    • O14871
    • Q6FI26

    Protein attributes for CCT7 Gene

    Size:
    543 amino acids
    Molecular mass:
    59367 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.

    Alternative splice isoforms for CCT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT7 Gene

Proteomics data for CCT7 Gene at MOPED

Post-translational modifications for CCT7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys47, Lys55, Lys67, Lys77, Lys84, Lys109, Lys135, Lys166, Lys172, Lys218, Lys277, Lys292, Lys368, Lys418, Lys430, Lys440, Lys463, and Lys521

Other Protein References for CCT7 Gene

No data available for DME Specific Peptides for CCT7 Gene

Domains for CCT7 Gene

Gene Families for CCT7 Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

UniProtKB/Swiss-Prot:

TCPH_HUMAN
Family:
  • Belongs to the TCP-1 chaperonin family.:
    • Q99832
genes like me logo Genes that share domains with CCT7: view

Function for CCT7 Gene

Molecular function for CCT7 Gene

UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Ontology (GO) - Molecular Function for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0042802 identical protein binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT7: view
genes like me logo Genes that share phenotypes with CCT7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT7 Gene

Localization for CCT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT7 Gene COMPARTMENTS Subcellular localization image for CCT7 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm TAS 9819444
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
genes like me logo Genes that share ontologies with CCT7: view

Pathways for CCT7 Gene

genes like me logo Genes that share pathways with CCT7: view

Gene Ontology (GO) - Biological Process for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT7: view

Transcripts for CCT7 Gene

Unigene Clusters for CCT7 Gene

Chaperonin containing TCP1, subunit 7 (eta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - -
SP14:
SP15:

ExUns: 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:

Relevant External Links for CCT7 Gene

GeneLoc Exon Structure for
CCT7
ECgene alternative splicing isoforms for
CCT7

Expression for CCT7 Gene

mRNA expression in normal human tissues for CCT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT7 Gene

SOURCE GeneReport for Unigene cluster for CCT7 Gene Hs.368149

genes like me logo Genes that share expressions with CCT7: view

Orthologs for CCT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT7 36
  • 99.69 (n)
  • 100 (a)
CCT7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT7 36
  • 91.22 (n)
  • 98.16 (a)
CCT7 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT7 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct7 36
  • 89.87 (n)
  • 96.98 (a)
Cct7 16
Cct7 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT7 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT7 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct7 36
  • 90.43 (n)
  • 97 (a)
chicken
(Gallus gallus)
Aves CCT7 36
  • 81.51 (n)
  • 94.53 (a)
CCT7 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT7 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6672 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cct7 36
  • 79.8 (n)
  • 90.43 (a)
Str.2286 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12021 36
zebrafish
(Danio rerio)
Actinopterygii cct7 36
  • 78.74 (n)
  • 88.18 (a)
cct7 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002762 36
  • 69.66 (n)
  • 77.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tcp-1eta 36
  • 69.78 (n)
  • 76.53 (a)
Tcp-1eta 37
  • 75 (a)
OneToOne
CG8351 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-7 36
  • 62.97 (n)
  • 65.39 (a)
cct-7 37
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR067W 36
  • 63.97 (n)
  • 65.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT7 36
  • 61.04 (n)
  • 64.3 (a)
CCT7 37
  • 62 (a)
OneToOne
CCT7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21340g 36
  • 61.54 (n)
  • 65.96 (a)
soybean
(Glycine max)
eudicotyledons Gma.8037 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11830 36
  • 63.56 (n)
  • 68.57 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3076 36
corn
(Zea mays)
Liliopsida Zm.3176 36
rice
(Oryza sativa)
Liliopsida Os.11699 36
Os06g0687700 36
  • 63.24 (n)
  • 69.2 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14018 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09700 36
  • 63.1 (n)
  • 64.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct7 36
  • 62.32 (n)
  • 66.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4924 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5206 37
  • 79 (a)
OneToOne
Species with no ortholog for CCT7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT7 Gene

ENSEMBL:
Gene Tree for CCT7 (if available)
TreeFam:
Gene Tree for CCT7 (if available)

Paralogs for CCT7 Gene

Selected SIMAP similar genes for CCT7 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT7 Gene

genes like me logo Genes that share paralogs with CCT7: view

No data available for Paralogs for CCT7 Gene

Variants for CCT7 Gene

Sequence variations from dbSNP and Humsavar for CCT7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7851 -- 73,251,333(+) GGGGC(A/T)TATGC reference, synonymous-codon, nc-transcript-variant
rs520474 -- 73,245,313(+) CCATT(C/T)AACAA intron-variant
rs523355 -- 73,246,185(+) ACTGG(C/G)AATTT intron-variant
rs909065 -- 73,250,223(-) CCCCA(A/G)CACTC intron-variant
rs1018342 -- 73,244,525(-) GCAGA(A/C)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT7 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV Loss 18451855

Relevant External Links for CCT7 Gene

HapMap Linkage Disequilibrium report
CCT7
Human Gene Mutation Database (HGMD)
CCT7

Disorders for CCT7 Gene

(1) University of Copenhagen DISEASES for CCT7 Gene

Relevant External Links for CCT7

Genetic Association Database (GAD)
CCT7
Human Genome Epidemiology (HuGE) Navigator
CCT7
genes like me logo Genes that share disorders with CCT7: view

No data available for UniProtKB/Swiss-Prot for CCT7 Gene

Publications for CCT7 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4
  2. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for CCT7 Gene

Sources for CCT7 Gene

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