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Aliases for CCT7 Gene

Aliases for CCT7 Gene

  • Chaperonin Containing TCP1 Subunit 7 2 3
  • Chaperonin Containing TCP1, Subunit 7 (Eta) 2 3 5
  • HIV-1 Nef-Interacting Protein 3 4
  • TCP-1-Eta 3 4
  • CCT-Eta 3 4
  • NIP7-1 3 4
  • CCTH 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit 3
  • HIV-1 Nef Interacting Protein 3
  • TCP1ETA 3
  • CCTETA 3

External Ids for CCT7 Gene

Previous GeneCards Identifiers for CCT7 Gene

  • GC02P073470
  • GC02P073672
  • GC02P073419
  • GC02P073435
  • GC02P073373
  • GC02P073314
  • GC02P073460
  • GC02P073197

Summaries for CCT7 Gene

Entrez Gene Summary for CCT7 Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

GeneCards Summary for CCT7 Gene

CCT7 (Chaperonin Containing TCP1 Subunit 7) is a Protein Coding gene. Diseases associated with CCT7 include myocardial infarction and babesiosis. Among its related pathways are Chaperonin-mediated protein folding and G-protein activation. GO annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT7 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT7 Gene

Genomics for CCT7 Gene

Regulatory Elements for CCT7 Gene

Enhancers for CCT7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCT7 on UCSC Golden Path with GeneCards custom track

Promoters for CCT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT7 Gene

Chromosome:
2
Start:
73,233,420 bp from pter
End:
73,253,022 bp from pter
Size:
19,603 bases
Orientation:
Plus strand

Genomic View for CCT7 Gene

Genes around CCT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT7 Gene

Proteins for CCT7 Gene

  • Protein details for CCT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99832-TCPH_HUMAN
    Recommended name:
    T-complex protein 1 subunit eta
    Protein Accession:
    Q99832
    Secondary Accessions:
    • A8K7E6
    • A8MWI8
    • B7WNW9
    • B7Z4T9
    • B7Z4Z7
    • O14871
    • Q6FI26

    Protein attributes for CCT7 Gene

    Size:
    543 amino acids
    Molecular mass:
    59367 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.

    Alternative splice isoforms for CCT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT7 Gene

Proteomics data for CCT7 Gene at MOPED

Post-translational modifications for CCT7 Gene

  • Ubiquitination at Lys 47, Lys 55, Lys 77, Lys 84, Lys 109, Lys 135, Lys 166, Lys 172, Lys 218, Lys 277, Lys 368, Lys 418, Lys 430, Lys 440, and Lys 521
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT7 Gene

Domains & Families for CCT7 Gene

Gene Families for CCT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q99832

UniProtKB/Swiss-Prot:

TCPH_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT7: view

Function for CCT7 Gene

Molecular function for CCT7 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
genes like me logo Genes that share phenotypes with CCT7: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT7 Gene

Localization for CCT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT7 Gene COMPARTMENTS Subcellular localization image for CCT7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9819444
genes like me logo Genes that share ontologies with CCT7: view

Pathways & Interactions for CCT7 Gene

genes like me logo Genes that share pathways with CCT7: view

Gene Ontology (GO) - Biological Process for CCT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0050821 protein stabilization IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT7: view

No data available for SIGNOR curated interactions for CCT7 Gene

Drugs & Compounds for CCT7 Gene

No Compound Related Data Available

Transcripts for CCT7 Gene

Unigene Clusters for CCT7 Gene

Chaperonin containing TCP1, subunit 7 (eta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - -
SP14:
SP15:

ExUns: 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:

Relevant External Links for CCT7 Gene

GeneLoc Exon Structure for
CCT7
ECgene alternative splicing isoforms for
CCT7

Expression for CCT7 Gene

mRNA expression in normal human tissues for CCT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT7 Gene



SOURCE GeneReport for Unigene cluster for CCT7 Gene Hs.368149

genes like me logo Genes that share expression patterns with CCT7: view

Protein tissue co-expression partners for CCT7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT7 Gene

Orthologs for CCT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT7 35
  • 91.22 (n)
  • 98.16 (a)
CCT7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct7 35
  • 89.87 (n)
  • 96.98 (a)
Cct7 16
Cct7 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT7 35
  • 99.69 (n)
  • 100 (a)
CCT7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct7 35
  • 90.43 (n)
  • 97 (a)
dog
(Canis familiaris)
Mammalia CCT7 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT7 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT7 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT7 35
  • 81.51 (n)
  • 94.53 (a)
CCT7 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct7 35
  • 79.8 (n)
  • 90.43 (a)
Str.2286 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6672 35
zebrafish
(Danio rerio)
Actinopterygii cct7 35
  • 78.74 (n)
  • 88.18 (a)
cct7 36
  • 88 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12021 35
fruit fly
(Drosophila melanogaster)
Insecta CG8351 37
  • 76 (a)
Tcp-1eta 35
  • 69.78 (n)
  • 76.53 (a)
Tcp-1eta 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002762 35
  • 69.66 (n)
  • 77.67 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-7 35
  • 62.97 (n)
  • 65.39 (a)
cct-7 36
  • 64 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR067W 35
  • 63.97 (n)
  • 65.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21340g 35
  • 61.54 (n)
  • 65.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT7 35
  • 61.04 (n)
  • 64.3 (a)
CCT7 36
  • 62 (a)
OneToOne
CCT7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11830 35
  • 63.56 (n)
  • 68.57 (a)
soybean
(Glycine max)
eudicotyledons Gma.8037 35
barley
(Hordeum vulgare)
Liliopsida Hv.3076 35
rice
(Oryza sativa)
Liliopsida Os.11699 35
Os06g0687700 35
  • 63.24 (n)
  • 69.2 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14018 35
corn
(Zea mays)
Liliopsida Zm.3176 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4924 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09700 35
  • 63.1 (n)
  • 64.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct7 35
  • 62.32 (n)
  • 66.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5206 36
  • 79 (a)
OneToOne
Species with no ortholog for CCT7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT7 Gene

ENSEMBL:
Gene Tree for CCT7 (if available)
TreeFam:
Gene Tree for CCT7 (if available)

Paralogs for CCT7 Gene

(8) SIMAP similar genes for CCT7 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCT7 Gene

genes like me logo Genes that share paralogs with CCT7: view

No data available for Paralogs for CCT7 Gene

Variants for CCT7 Gene

Sequence variations from dbSNP and Humsavar for CCT7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2231427 - 73,247,918(+) TCCAC(A/G)CAGTT nc-transcript-variant, reference, missense
rs520474 -- 73,245,313(+) CCATT(C/T)AACAA intron-variant
rs523355 -- 73,246,185(+) ACTGG(C/G)AATTT intron-variant
rs1864487 -- 73,244,223(+) GACTT(C/G/T)CTGTG intron-variant
rs909065 -- 73,250,223(-) CCCCA(A/G)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT7 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV Loss 18451855

Variation tolerance for CCT7 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT7 Gene

HapMap Linkage Disequilibrium report
CCT7
Human Gene Mutation Database (HGMD)
CCT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT7 Gene

Disorders for CCT7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCT7 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
babesiosis
  • babesiasis
cavernous malformation
- elite association - COSMIC cancer census association via MalaCards
Search CCT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT7

Genetic Association Database (GAD)
CCT7
Human Genome Epidemiology (HuGE) Navigator
CCT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT7
genes like me logo Genes that share disorders with CCT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT7 Gene

Publications for CCT7 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3

Products for CCT7 Gene

Sources for CCT7 Gene

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