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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCT7 Gene

protein-coding GIFtS: 63
GCID: GC02P073460

chaperonin containing TCP1, subunit 7 (eta)

Explore 7 diseases affiliated with
CCT7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chaperonin Containing TCP1, Subunit 7 (Eta)¹ ²		Nip7-1¹
CCT-Eta¹		CCTETA²
CCTH² ³		TCP1ETA²
NIP7-1² ³		Chaperonin Containing T-Complex Polypeptide 1, Eta Subunit²
TCP-1-Eta¹		HIV-1 Nef Interacting Protein²
HIV-1 Nef-Interacting Protein² ³		T-Complex Protein 1 Subunit Eta²
Ccth¹

External Ids:	HGNC: 1622¹	Entrez Gene: 10574²	Ensembl: ENSG00000135624⁷	OMIM: 605140⁵	UniProtKB: Q99832³

ORGUL members:
	NONCODE:n408334 n408333

Export aliases for CCT7 gene to outside databases

Previous GC identifers: GC02P073470 GC02P073672 GC02P073419 GC02P073435 GC02P073373 GC02P073314 GC02P073197

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT7:

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as

the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different

proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The

complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript

variants. Related pseudogenes have been identified on chromosomes 5 and 6. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in

the folding of actin and tubulin (By similarity)

Gene Wiki entry for CCT7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCT7 gene promoter:
Pax-5 HOXA3 NF-kappaB NF-AT CREB NF-AT4 NF-AT2 NF-AT3 NF-kappaB1 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCT7 promoter sequence

Search SABiosciences Chromatin IP Primers for CCT7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.2 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p13.2

CCT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT7 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P073460: view genomic region (about GC identifiers)

Start:	73,460,548 bp from pter	End:	73,480,150 bp from pter
Size:	19,603 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

n408333
n408334

lncRNA
Full Legend

73461363 73470757 73480150 chr2

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832 (See protein sequence)

Recommended Name: T-complex protein 1 subunit eta

Size: 543 amino acids; 59367 Da

Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Interacts with PACRG

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: A8K7E6 A8MWI8 B7WNW9 B7Z4T9 B7Z4Z7 O14871 Q6FI26

Alternative splicing: 4 isoforms: Q99832-1 Q99832-2 Q99832-3 Q99832-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT7: NX_Q99832

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99832

CCT7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001009570.1 NP_001159756.1 NP_001159757.1 NP_006420.1

ENSEMBL proteins:

ENSP00000258091 ENSP00000412996 ENSP00000381456 ENSP00000386978 ENSP00000386349

ENSP00000442058 ENSP00000437824 ENSP00000444379 ENSP00000438462

Reactome Protein details: Q99832
Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): CCT7 OriGene Custom Protein Services for CCT7
	GenScript Custom Purified and Recombinant Proteins Services for CCT7
	Novus Biologicals CCT7 Proteins Novus Biologicals CCT7 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCT7

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005832	chaperonin-containing T-complex	IEA	--
GO:0005874	microtubule	IDA	--

CCT7 for ontologies About GeneDecksing

CCT7 Antibody Products:

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	Novus Biologicals CCT7 Antibodies
	Abcam antibodies for CCT7
	Uscn Antibodies for CCT7
	Search ThermoFisher Antibodies for CCT7

Assay Products for CCT7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCT7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCT7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCT7 for domains About GeneDecksing

4 InterPro domains/families:

IPR017998 Chaperone_TCP-1

IPR002194 Chaperonin_TCP-1_CS

IPR012720 Chap_CCT_eta

IPR002423 Cpn60/TCP-1

Graphical View of Domain Structure for InterPro Entry Q99832

ProtoNet protein and cluster: Q99832

2 Blocks protein families:

IPB001844 Chaperonin Cpn60

IPB002194 Chaperonin TCP-1

UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832

Similarity: Belongs to the TCP-1 chaperonin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCPH_HUMAN, Q99832

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in

the folding of actin and tubulin (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): CCT7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT7
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT7:
		hsa-miR-502-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CCT7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT7 (see all 7) OriGene shRNA RFP: CCT7 OriGene siRNA: CCT7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT7

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCT7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT7 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT7 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCT7 (NM_006429)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCT7
		Search LifeMap BioReagents cell lines for CCT7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT7

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0042802	identical protein binding	IEA	--
GO:0051082	unfolded protein binding	IEA	--

CCT7 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for CCT7:

Cell division defect	Decreased POU5F1-GFP protein e	Decreased TP53 protein express	Decreased viability of wild-ty
Increased S DNA content	Increased gamma-H2AX phosphory	Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of tubulin folding intermediates by CCT/TriC

	Formation of tubulin folding intermediates by CCT/TriC	1.00			Prefoldin mediated transfer of substrate to CCT/TriC	0.70
	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.74			Folding of actin by CCT/TriC	0.38

Chaperonin-mediated protein folding

	Chaperonin-mediated protein folding	1.00			Association of TriC/CCT with target proteins during biosynthesis	0.60
	Protein folding	0.91

Cell cycle Role of APC in cell cycle regulation

Cell cycle Role of APC in cell cycle regulation

1.00

Cell cycle_Role of APC in cell cycle regulation

0.98

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCT7

Cell cycle Role of APC in cell cycle regulation

1 GeneGo (Thomson Reuters) Pathway for CCT7

Cell cycle Role of APC in cell cycle regulation

5/8 Reactome Pathways for CCT7 (see all 8)

	Formation of tubulin folding intermediates by CCT/TriC
	Association of TriC/CCT with target proteins during biosynthesis
	Chaperonin-mediated protein folding
	Prefoldin mediated transfer of substrate to CCT/TriC
	Metabolism of proteins

CCT7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCT7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/923 Interacting proteins for CCT7 (Q99832^{2, 3} ENSP00000258091⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 923)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCP1	P17987²^,³, ENSP00000317334⁴	MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=5 STRING: ENSP00000317334
CCT4	P50991²^,³, ENSP00000377958⁴	MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000377958
CCT3	P49368²^,³, ENSP00000357244⁴	MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=1 STRING: ENSP00000357244
DNM2	P50570²^,³	MINT-7945693 MINT-8254382 MINT-7947479 I2D: score=2
ENSG00000258947	Q13509²^,³	MINT-7945693 MINT-8415355 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--
GO:0051084	'de novo' posttranslational protein folding	TAS	--

CCT7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCT7
Search CenterWatch for drugs/clinical trials and news about CCT7 / TCPH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCT7 gene (4 alternative transcripts):

NM_001009570.2 NM_001166284.1 NM_001166285.1 NM_006429.3

Unigene Cluster for CCT7:

Chaperonin containing TCP1, subunit 7 (eta)

Hs.368149 [show with all ESTs]

Unigene Representative Sequence: NM_001166285

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000471927 ENST00000469844 ENST00000473197 ENST00000492253 ENST00000258091

ENST00000461290 ENST00000464397 ENST00000399032 ENST00000398422 ENST00000480489

ENST00000409924 ENST00000409081 ENST00000473786 ENST00000482064 ENST00000488856

ENST00000540468(uc010yri.2 uc002sja.3) ENST00000539919(uc010yrf.2 uc002siz.3 uc010yrh.2 uc010yrg.2)

ENST00000537131

miRNA Products:		OriGene 3'-UTR Clone (see all 4): CCT7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT7
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT7:
		hsa-miR-502-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CCT7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT7 (see all 7) OriGene shRNA RFP: CCT7 OriGene siRNA: CCT7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT7 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT7 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CCT7 (NM_006429)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT7

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT7

Additional cDNA sequence:

AF026292.1 AK098549.1 AK098825.1 AK222478.1 AK291961.1 AK293175.1 AK293597.1 AK297846.1

AK298153.1 AK302078.1 BC019296.1 BC088351.1 CR456719.1 CR536511.1 NR_029402.1 NR_029403.1

U83843.1

24/47 DOTS entries (see all 47):

DT.91776362 DT.452195 DT.100689500 DT.95152728 DT.100689507 DT.95152770 DT.100689497 DT.100689486

DT.100689490 DT.87017058 DT.100689493 DT.120971312 DT.120971369 DT.99980935 DT.100689472 DT.121383108

DT.95152722 DT.100689476 DT.120971368 DT.92050813 DT.100689474 DT.100689483 DT.120971325 DT.97868470

24/1694 AceView cDNA sequences (see all 1694):

BQ225874 CR596863 AK098549 BX398856 BE728627 BI198080 BU196895 BM713475

BU169132 CR619505 BU191422 BU556804 BQ691898 BU149554 BQ061892 BM556737

BP377725 CR598786 CR624089 CN482799 AU156494 BP350656 CR608380 AU076737

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CCT7 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·
SP1:									-												-										-		-				-
SP2:																															-		-				-
SP3:																					-										-		-				-
SP4:									-												-										-		-				-						-
SP5:																					-										-		-				-

ExUns:	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CCT7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGCTGGC

About this image

CCT7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCT7

SOURCE GeneReport for Unigene cluster: Hs.368149

SABiosciences Expression via Pathway-Focused PCR Arrays including CCT7:

Cellular Stress Responses in human mouse rat

Unfolded Protein Response in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT7 gene from 9/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCT7¹	chaperonin containing TCP1, subunit 7 (eta)	81.3(n) 94.07(a)		428806 NM_001031541.1 NP_001026712.1
lizard (Anolis carolinensis)	Reptilia	CCT7⁶	--	90(a)	1 ↔ 1	GL343815.1(33863-44124)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6672²	Xenopus laevis, Similar to chaperonin subunit 7 (eta), more	80.32(n)		BC045074.1
zebrafish (Danio rerio)	Actinopterygii	cct7²	chaperonin containing TCP1, subunit 7 (eta)	79.94(n)		192324 AF506229.1
fruit fly (Drosophila melanogaster)	Insecta	CG8351³ Tcp-1eta¹	chaperonin ATPase³ CG8351-PA¹	76(a)³ 69.32(n)¹ 75.93(a)¹		41054¹ NM_141578.1¹ NP_649835.1¹
worm (Caenorhabditis elegans)	Secernentea	cct-7¹	Protein CCT-7	62.97(n) 65.39(a)		178670 NM_071121.3 NP_503522.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CCT7(YJL111W)⁴ CCT7¹	Subunit of the cytosolic chaperonin Cct ring complex, more⁴ Cct7p¹	60.71(n)¹ 63.91(a)¹		10(207877-209529)⁴ 853333^{1, 4} NP_012424.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G11830¹	TCP-1/cpn60 chaperonin family protein	63.15(n) 68.39(a)		820356 NM_112016.4 NP_187789.1
rice (Oryza sativa)	Liliopsida	Os.11699²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	75.91(n)		AK109357.1

ENSEMBL Gene Tree for CCT7 (if available)
TreeFam Gene Tree for CCT7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCT7 gene

8 SIMAP similar genes for CCT7 using alignment to 7 protein entries: TCPH_HUMAN (see all proteins):

TCP1 CCT3 CCT4 CCT5 CCT2 CCT8

CCT6A CCT6B

CCT7 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for CCT7
PGOHUM00000235311 PGOHUM00000243814

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191187839^1,2		--	73459375(+)	`CAGGAC/GAATGG`	7	--	us2k¹ int¹		0	--	--	--	--
rs182149016^1,2		--	73459416(+)	`GCCGAA/GATCGG`	7	--	int¹ us2k¹		0	--	--	--	--
rs70965721^1,2	C	--	73459465(+)	`GTCTC-/AAAAAA`	7	--	us2k¹ int¹		2		NA CSA	4
rs187854973^1,2		--	73459654(+)	`TGGGGA/CCTCCC`	7	--	us2k¹ int¹		0	--	--	--	--
rs57459995^1,2	C,	--	73459677(+)	`ACCCCC/-AGAAA`	7	--	us2k¹ int¹		1		CSA	2
rs75076379^1,2	C	--	73459845(+)	`TGCGTG/TTGTGC`	7	--	us2k¹ int¹		0	--	--	--	--
rs114101558^1,2		--	73459910(+)	`CCAGCC/TTGTAG`	7	--	int¹ us2k¹		1		WA	118
rs3832032^1,2	C	--	73460294(-)	`GGCCCGGCCC/- TGGAG`	8	--	us2k¹ ut5¹		1		NA	2
rs70965722^1,2	C,	--	73460294(+)	`GGGCC-/GGGCC CGGCC`	7	--	us2k¹ ut5¹		1		NA	2
rs57336116^1,2	C,	--	73460517(+)	`AGAAGT/GGGAGC`	7	--	us2k¹		3		NA WA	240

HapMap Linkage Disequilibrium report for CCT7 (73460548 - 73480150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCT7: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCT7 for disorders           About GeneDecksing

OMIM gene information: 605140    OMIM disorders: --

7 diseases for CCT7:    About MalaCards

cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 babesiosis

cerebritis breast cancer malaria

1 disease from the University of Copenhagen DISEASES database for CCT7:

Babesiosis

Human Genome Epidemiology (HuGE) Navigator: CCT7 (1 document)

Export disorders for CCT7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCT7 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with CCT7)

Utopia: connect your pdf to the dynamic
world of online information

Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PubMed id 9819444)^{1, 2, 3} Won K.-A.... Reed S.I. (1998)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)^{1, 2} Imai Y.... Takahashi R. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10574	HGNC: 1622	AceView: CCT7	Ensembl:ENSG00000135624	euGenes: HUgn10574
ECgene: CCT7	H-InvDB: CCT7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCT7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCT7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCT7 gene:
Search GeneIP for patents involving CCT7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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chaperonin containing TCP1, subunit 7 (eta)

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CCT7 Gene

chaperonin containing TCP1, subunit 7 (eta)

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