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Aliases for CCT6B Gene

Aliases for CCT6B Gene

  • Chaperonin Containing TCP1, Subunit 6B (Zeta 2) 2 3
  • Testis-Specific Protein TSA303 3 4
  • Testis-Specific Tcp20 3 4
  • TCP-1-Zeta-2 3 4
  • CCT-Zeta-2 3 4
  • Cctz2 3 6
  • Chaperonin-Containing T-Complex Polypeptide 1, Subunit 6B 3
  • T-Complex Protein 1 Subunit Zeta-2 3
  • TCP-1-Zeta-Like 4
  • CCT-Zeta-Like 4
  • CCTZ-2 3
  • TSA303 3

External Ids for CCT6B Gene

Previous GeneCards Identifiers for CCT6B Gene

  • GC17M033024
  • GC17M035290
  • GC17M033400
  • GC17M030279
  • GC17M033254
  • GC17M029439

Summaries for CCT6B Gene

Entrez Gene Summary for CCT6B Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for CCT6B Gene

CCT6B (Chaperonin Containing TCP1, Subunit 6B (Zeta 2)) is a Protein Coding gene. Among its related pathways are Cell cycle_Role of APC in cell cycle regulation. GO annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.

UniProtKB/Swiss-Prot for CCT6B Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6B Gene

Genomics for CCT6B Gene

Regulatory Elements for CCT6B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCT6B Gene

Start:
34,927,859 bp from pter
End:
34,981,078 bp from pter
Size:
53,220 bases
Orientation:
Minus strand

Genomic View for CCT6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6B Gene

Proteins for CCT6B Gene

  • Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92526-TCPW_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Protein Accession:
    Q92526
    Secondary Accessions:
    • B4DX20
    • B4DYB0
    • Q8TC34

    Protein attributes for CCT6B Gene

    Size:
    530 amino acids
    Molecular mass:
    57821 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter

    Alternative splice isoforms for CCT6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6B Gene

Proteomics data for CCT6B Gene at MOPED

Post-translational modifications for CCT6B Gene

  • Ubiquitination at Lys41
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT6B Gene

No data available for DME Specific Peptides for CCT6B Gene

Domains for CCT6B Gene

Gene Families for CCT6B Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

Graphical View of Domain Structure for InterPro Entry

Q92526

UniProtKB/Swiss-Prot:

TCPW_HUMAN :
  • Q92526
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6B: view

Function for CCT6B Gene

Molecular function for CCT6B Gene

GENATLAS Biochemistry: chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Ontology (GO) - Molecular Function for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008565 protein transporter activity TAS 8812458
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT6B: view

Phenotypes for CCT6B Gene

GenomeRNAi human phenotypes for CCT6B:
genes like me logo Genes that share phenotypes with CCT6B: view

Animal Model Products

miRNA for CCT6B Gene

miRTarBase miRNAs that target CCT6B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT6B Gene

Localization for CCT6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT6B Gene COMPARTMENTS Subcellular localization image for CCT6B gene
Compartment Confidence
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005832 chaperonin-containing T-complex IEA --
genes like me logo Genes that share ontologies with CCT6B: view

Pathways for CCT6B Gene

genes like me logo Genes that share pathways with CCT6B: view

Pathways by source for CCT6B Gene

1 GeneGo (Thomson Reuters) pathway for CCT6B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0007283 spermatogenesis TAS 8812458
GO:0015031 protein transport TAS 8812458
GO:0044267 cellular protein metabolic process --
GO:0051131 chaperone-mediated protein complex assembly TAS 8812458
genes like me logo Genes that share ontologies with CCT6B: view

Transcripts for CCT6B Gene

Unigene Clusters for CCT6B Gene

Chaperonin containing TCP1, subunit 6B (zeta 2):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT6B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: -

Relevant External Links for CCT6B Gene

GeneLoc Exon Structure for
CCT6B
ECgene alternative splicing isoforms for
CCT6B

Expression for CCT6B Gene

mRNA expression in normal human tissues for CCT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCT6B Gene

This gene is overexpressed in Testis (23.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT6B Gene

SOURCE GeneReport for Unigene cluster for CCT6B Gene Hs.73072

mRNA Expression by UniProt/SwissProt for CCT6B Gene

Q92526-TCPW_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with CCT6B: view

In Situ Assay Products

Orthologs for CCT6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT6B 35
  • 99.25 (n)
  • 99.06 (a)
CCT6B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT6B 35
  • 91.01 (n)
  • 91.32 (a)
CCT6B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
CCT6B 35
  • 91.82 (n)
  • 92.45 (a)
mouse
(Mus musculus)
Mammalia Cct6b 35
  • 83.96 (n)
  • 83.58 (a)
Cct6b 16
Cct6b 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT6B 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cct6b 35
  • 84.47 (n)
  • 83.4 (a)
chicken
(Gallus gallus)
Aves CCT6 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6143 35
zebrafish
(Danio rerio)
Actinopterygii cct6a 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tcp-1zeta 36
  • 68 (a)
OneToMany
CG8231 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-6 36
  • 64 (a)
OneToMany
cct-6 37
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 36
  • 71 (a)
OneToMany
Species with no ortholog for CCT6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT6B Gene

ENSEMBL:
Gene Tree for CCT6B (if available)
TreeFam:
Gene Tree for CCT6B (if available)

Paralogs for CCT6B Gene

Paralogs for CCT6B Gene

Selected SIMAP similar genes for CCT6B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCT6B Gene

genes like me logo Genes that share paralogs with CCT6B: view

Variants for CCT6B Gene

Sequence variations from dbSNP and Humsavar for CCT6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs978202 -- 34,974,196(+) AAGAA(C/T)GATGA intron-variant
rs1351554 -- 34,970,046(+) TCACT(C/T)CATTT intron-variant
rs1384139 -- 34,933,327(+) GATAT(C/G)ACTTT intron-variant
rs1871866 -- 34,969,230(+) ACACT(A/G)GGAAG intron-variant
rs1967013 -- 34,958,393(+) GAGCC(A/G)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6B Gene

Variant ID Type Subtype PubMed ID
nsv526685 CNV Gain 19592680

Relevant External Links for CCT6B Gene

HapMap Linkage Disequilibrium report
CCT6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene

Disorders for CCT6B Gene

No disorders were found for CCT6B Gene.

No data available for UniProtKB/Swiss-Prot for CCT6B Gene

Publications for CCT6B Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K. … Nakamura Y. (Genomics 1996) 2 3 4 23
  2. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H. … Willison K.R. (FEBS Lett. 1997) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. (PMID: 16415341) Stirling P.C. … Leroux M.R. (J. Biol. Chem. 2006) 3

Products for CCT6B Gene

Sources for CCT6B Gene

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