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Aliases for CCT6B Gene

Aliases for CCT6B Gene

  • Chaperonin Containing TCP1 Subunit 6B 2 3 5
  • Chaperonin Containing TCP1, Subunit 6B (Zeta 2) 2 3
  • Testis-Specific Protein TSA303 3 4
  • Testis-Specific Tcp20 3 4
  • TCP-1-Zeta-2 3 4
  • CCT-Zeta-2 3 4
  • Chaperonin-Containing T-Complex Polypeptide 1, Subunit 6B 3
  • T-Complex Protein 1 Subunit Zeta-2 3
  • TCP-1-Zeta-Like 4
  • CCT-Zeta-Like 4
  • CCTZ-2 3
  • TSA303 3
  • Cctz2 3

External Ids for CCT6B Gene

Previous GeneCards Identifiers for CCT6B Gene

  • GC17M033024
  • GC17M035290
  • GC17M033400
  • GC17M030279
  • GC17M033254
  • GC17M029439

Summaries for CCT6B Gene

Entrez Gene Summary for CCT6B Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for CCT6B Gene

CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include Pelvic Varices. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.

UniProtKB/Swiss-Prot for CCT6B Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6B Gene

Genomics for CCT6B Gene

Regulatory Elements for CCT6B Gene

Enhancers for CCT6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G035083 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -106.1 -106085 6.6 HDGF FOXA2 PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 LIG3 RFFL SLFN5 ZNF830 CCT6B NLE1 RPL37P22
GH17G035081 1.3 Ensembl ENCODE dbSUPER 10.4 -101.5 -101490 2.0 HDGF PKNOX1 JUN FOSL1 ZNF316 GATA2 ZNF366 PRDM10 FOS ZBTB20 LIG3 CCT6B ZNF830 NLE1 RPL37P22 RFFL
GH17G035080 1 Ensembl dbSUPER 10.4 -99.7 -99723 0.4 TBP RELA POLR2A EED ETV6 RELB IKZF2 CREM MTA2 TRIM22 LIG3 CCT6B ZNF830 NLE1 RPL37P22 RFFL
GH17G035062 1.4 ENCODE dbSUPER 7.2 -83.1 -83149 3.9 PKNOX1 FOXA2 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LIG3 RFFL LINC02001 RNU6-840P CCT6B GC17M035056 ENSG00000267457
GH17G035160 0.9 FANTOM5 ENCODE 6.8 -180.5 -180454 3.0 BCOR SMARCA5 NFIB HLF ZMYM3 MAX CEBPG ZBTB40 NFIC KDM1A LIG3 CCT6B SLFN5 SLFN12L ZNF830 ENSG00000267782 UNC45B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCT6B on UCSC Golden Path with GeneCards custom track

Promoters for CCT6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093423 178 1801 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CCT6B Gene

Chromosome:
17
Start:
34,927,859 bp from pter
End:
34,981,078 bp from pter
Size:
53,220 bases
Orientation:
Minus strand

Genomic View for CCT6B Gene

Genes around CCT6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6B Gene

Proteins for CCT6B Gene

  • Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92526-TCPW_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Protein Accession:
    Q92526
    Secondary Accessions:
    • B4DX20
    • B4DYB0
    • Q8TC34

    Protein attributes for CCT6B Gene

    Size:
    530 amino acids
    Molecular mass:
    57821 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Alternative splice isoforms for CCT6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6B Gene

Post-translational modifications for CCT6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCT6B Gene

Domains & Families for CCT6B Gene

Gene Families for CCT6B Gene

Graphical View of Domain Structure for InterPro Entry

Q92526

UniProtKB/Swiss-Prot:

TCPW_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6B: view

Function for CCT6B Gene

Molecular function for CCT6B Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Ontology (GO) - Molecular Function for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008565 protein transporter activity TAS 8812458
GO:0044183 protein binding involved in protein folding IBA --
GO:0051082 unfolded protein binding IBA,TAS --
genes like me logo Genes that share ontologies with CCT6B: view
genes like me logo Genes that share phenotypes with CCT6B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCT6B

miRNA for CCT6B Gene

miRTarBase miRNAs that target CCT6B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6B Gene

Localization for CCT6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT6B gene
Compartment Confidence
cytosol 5
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005832 chaperonin-containing T-complex IBA --
genes like me logo Genes that share ontologies with CCT6B: view

Pathways & Interactions for CCT6B Gene

genes like me logo Genes that share pathways with CCT6B: view

Gene Ontology (GO) - Biological Process for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8812458
GO:0006458 de novo protein folding IBA --
GO:0007283 spermatogenesis TAS 8812458
GO:0015031 protein transport IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 8812458
genes like me logo Genes that share ontologies with CCT6B: view

No data available for SIGNOR curated interactions for CCT6B Gene

Transcripts for CCT6B Gene

Unigene Clusters for CCT6B Gene

Chaperonin containing TCP1, subunit 6B (zeta 2):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: -

Relevant External Links for CCT6B Gene

GeneLoc Exon Structure for
CCT6B
ECgene alternative splicing isoforms for
CCT6B

Expression for CCT6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCT6B Gene

This gene is overexpressed in Testis (x23.5).

Protein differential expression in normal tissues from HIPED for CCT6B Gene

This gene is overexpressed in Testis (27.1) and Ovary (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT6B Gene



NURSA nuclear receptor signaling pathways regulating expression of CCT6B Gene:

CCT6B

SOURCE GeneReport for Unigene cluster for CCT6B Gene:

Hs.73072

mRNA Expression by UniProt/SwissProt for CCT6B Gene:

Q92526-TCPW_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with CCT6B: view

Primer Products

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT6B Gene

Orthologs for CCT6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT6B 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia CCT6B 34
  • 91.82 (n)
-- 35
  • 90 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CCT6B 34 35
  • 91.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cct6b 34
  • 84.47 (n)
mouse
(Mus musculus)
Mammalia Cct6b 34 16 35
  • 83.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CCT6B 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT6 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6143 34
zebrafish
(Danio rerio)
Actinopterygii cct6a 35
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tcp-1zeta 35
  • 68 (a)
OneToMany
CG8231 36
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-6 36 35
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 35
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 35
  • 71 (a)
OneToMany
Species where no ortholog for CCT6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT6B Gene

ENSEMBL:
Gene Tree for CCT6B (if available)
TreeFam:
Gene Tree for CCT6B (if available)

Paralogs for CCT6B Gene

Paralogs for CCT6B Gene

(7) SIMAP similar genes for CCT6B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCT6B Gene

genes like me logo Genes that share paralogs with CCT6B: view

Variants for CCT6B Gene

Sequence variations from dbSNP and Humsavar for CCT6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000049411 -- 34,946,617(+) TTATA(G/T)CAGCA intron-variant
rs1000096608 -- 34,934,598(+) CCACT(A/T)AAGCT intron-variant
rs1000108026 -- 34,940,154(+) CCTTT(A/G)ACCCA intron-variant
rs1000125341 -- 34,978,523(+) GCCAA(C/T)ATCGT intron-variant, upstream-variant-2KB
rs1000173473 -- 34,947,631(+) ATCTA(C/T)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6B Gene

Variant ID Type Subtype PubMed ID
nsv526685 CNV gain 19592680

Variation tolerance for CCT6B Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.28; 97.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene

Disorders for CCT6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CCT6B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT6B
genes like me logo Genes that share disorders with CCT6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT6B Gene

Publications for CCT6B Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K. … Nakamura Y. (Genomics 1996) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H. … Willison K.R. (FEBS Lett. 1997) 2 3 64
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CCT6B Gene

Sources for CCT6B Gene

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