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Aliases for CCT6B Gene

Aliases for CCT6B Gene

  • Chaperonin Containing TCP1 Subunit 6B 2 3
  • Chaperonin Containing TCP1, Subunit 6B (Zeta 2) 2 3 5
  • Testis-Specific Protein TSA303 3 4
  • Testis-Specific Tcp20 3 4
  • TCP-1-Zeta-2 3 4
  • CCT-Zeta-2 3 4
  • Chaperonin-Containing T-Complex Polypeptide 1, Subunit 6B 3
  • TCP-1-Zeta-Like 4
  • CCT-Zeta-Like 4
  • CCTZ-2 3
  • TSA303 3
  • Cctz2 3

External Ids for CCT6B Gene

Previous GeneCards Identifiers for CCT6B Gene

  • GC17M033024
  • GC17M035290
  • GC17M033400
  • GC17M030279
  • GC17M033254
  • GC17M029439

Summaries for CCT6B Gene

Entrez Gene Summary for CCT6B Gene

  • This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for CCT6B Gene

CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include pelvic varices. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.

UniProtKB/Swiss-Prot for CCT6B Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Wiki entry for CCT6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6B Gene

Genomics for CCT6B Gene

Regulatory Elements for CCT6B Gene

Promoters for CCT6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT6B on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT6B Gene

Chromosome:
17
Start:
34,927,859 bp from pter
End:
34,981,078 bp from pter
Size:
53,220 bases
Orientation:
Minus strand

Genomic View for CCT6B Gene

Genes around CCT6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6B Gene

Proteins for CCT6B Gene

  • Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92526-TCPW_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Protein Accession:
    Q92526
    Secondary Accessions:
    • B4DX20
    • B4DYB0
    • Q8TC34

    Protein attributes for CCT6B Gene

    Size:
    530 amino acids
    Molecular mass:
    57821 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Alternative splice isoforms for CCT6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6B Gene

Proteomics data for CCT6B Gene at MOPED

Post-translational modifications for CCT6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCT6B Gene

No data available for DME Specific Peptides for CCT6B Gene

Domains & Families for CCT6B Gene

Gene Families for CCT6B Gene

Graphical View of Domain Structure for InterPro Entry

Q92526

UniProtKB/Swiss-Prot:

TCPW_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6B: view

Function for CCT6B Gene

Molecular function for CCT6B Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

Gene Ontology (GO) - Molecular Function for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CCT6B: view
genes like me logo Genes that share phenotypes with CCT6B: view

Animal Model Products

miRNA for CCT6B Gene

miRTarBase miRNAs that target CCT6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6B Gene

Localization for CCT6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT6B Gene COMPARTMENTS Subcellular localization image for CCT6B gene
Compartment Confidence
cytosol 4
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CCT6B Gene

Pathways & Interactions for CCT6B Gene

genes like me logo Genes that share pathways with CCT6B: view

Gene Ontology (GO) - Biological Process for CCT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 8812458
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT6B: view

No data available for SIGNOR curated interactions for CCT6B Gene

Drugs & Compounds for CCT6B Gene

No Compound Related Data Available

Transcripts for CCT6B Gene

Unigene Clusters for CCT6B Gene

Chaperonin containing TCP1, subunit 6B (zeta 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2:
SP3: -

Relevant External Links for CCT6B Gene

GeneLoc Exon Structure for
CCT6B
ECgene alternative splicing isoforms for
CCT6B

Expression for CCT6B Gene

mRNA expression in normal human tissues for CCT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCT6B Gene

This gene is overexpressed in Testis (x23.5).

Protein differential expression in normal tissues from HIPED for CCT6B Gene

This gene is overexpressed in Testis (27.1) and Ovary (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT6B Gene



SOURCE GeneReport for Unigene cluster for CCT6B Gene Hs.73072

mRNA Expression by UniProt/SwissProt for CCT6B Gene

Q92526-TCPW_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with CCT6B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CCT6B Gene

Orthologs for CCT6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCT6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT6B 36
  • 99 (a)
OneToOne
CCT6B 35
  • 99.25 (n)
  • 99.06 (a)
cow
(Bos Taurus)
Mammalia CCT6B 35
  • 91.01 (n)
  • 91.32 (a)
CCT6B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
CCT6B 35
  • 91.82 (n)
  • 92.45 (a)
mouse
(Mus musculus)
Mammalia Cct6b 16
Cct6b 36
  • 83 (a)
OneToOne
Cct6b 35
  • 83.96 (n)
  • 83.58 (a)
oppossum
(Monodelphis domestica)
Mammalia CCT6B 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cct6b 35
  • 84.47 (n)
  • 83.4 (a)
chicken
(Gallus gallus)
Aves CCT6 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6143 35
zebrafish
(Danio rerio)
Actinopterygii cct6a 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8231 37
  • 65 (a)
Tcp-1zeta 36
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cct-6 37
  • 61 (a)
cct-6 36
  • 64 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 36
  • 71 (a)
OneToMany
Species with no ortholog for CCT6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCT6B Gene

ENSEMBL:
Gene Tree for CCT6B (if available)
TreeFam:
Gene Tree for CCT6B (if available)

Paralogs for CCT6B Gene

Paralogs for CCT6B Gene

(7) SIMAP similar genes for CCT6B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCT6B Gene

genes like me logo Genes that share paralogs with CCT6B: view

Variants for CCT6B Gene

Sequence variations from dbSNP and Humsavar for CCT6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2230553 - 34,942,629(-) CTCTG(C/G)TTTCT reference, missense
VAR_060297 -
VAR_060298 -
rs2339120 -- 34,968,479(+) CTTTA(C/T)GAATT intron-variant
rs7223500 -- 34,928,552(+) ACGGG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6B Gene

Variant ID Type Subtype PubMed ID
nsv526685 CNV Gain 19592680

Variation tolerance for CCT6B Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.28; 97.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT6B Gene

HapMap Linkage Disequilibrium report
CCT6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene

Disorders for CCT6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT6B Gene - From: DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CCT6B in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT6B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT6B
genes like me logo Genes that share disorders with CCT6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT6B Gene

Publications for CCT6B Gene

  1. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K. … Nakamura Y. (Genomics 1996) 2 3 4 23 67
  2. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H. … Willison K.R. (FEBS Lett. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for CCT6B Gene

Sources for CCT6B Gene

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