Aliases for CCT6B Gene
Aliases for CCT6B Gene
External Ids for CCT6B Gene
- HGNC: 1621
- Entrez Gene: 10693
- Ensembl: ENSG00000132141
- OMIM: 610730
- UniProtKB: Q92526
Previous GeneCards Identifiers for CCT6B Gene
- GC17M033024
- GC17M035290
- GC17M033400
- GC17M030279
- GC17M033254
- GC17M029439
Summaries for CCT6B Gene
-
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for CCT6B Gene
CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include Pelvic Varices. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.
UniProtKB/Swiss-Prot for CCT6B Gene
-
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6B Gene
Genomics for CCT6B Gene
Regulatory Elements for CCT6B Gene
- Transcription factor binding sites by QIAGEN in the CCT6B gene promoter:
Regulatory Element Products
Genomic Location for CCT6B Gene
- Chromosome:
- 17
- Start:
- 34,927,859 bp from pter
- End:
- 34,981,078 bp from pter
- Size:
- 53,220 bases
- Orientation:
- Minus strand
Genomic View for CCT6B Gene
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCT6B Gene
Proteins for CCT6B Gene
-
Protein details for CCT6B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92526-TCPW_HUMAN
- Recommended name:
- T-complex protein 1 subunit zeta-2
- Protein Accession:
- Q92526
- B4DX20
- B4DYB0
- Q8TC34
Protein attributes for CCT6B Gene
- Size:
- 530 amino acids
- Molecular mass:
- 57821 Da
- Quaternary structure:
-
- Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Protein Expression for CCT6B Gene
Post-translational modifications for CCT6B Gene
Other Protein References for CCT6B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCT6B
- Novus Biologicals Antibodies for CCT6B
- Invitrogen Antibodies for CCT6B
- antibodies-online Antibodies for CCT6B: See all 22
- GeneTex CCT6B antibody for CCT6B
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCT6B
Protein Products
-
OriGene Purified Proteins for CCT6B
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- antibodies-online Proteins for CCT6B: See all 4
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- Search GeneTex for Proteins for CCT6B
Assay Products
- antibodies-online Kits for CCT6B: See all 3
No data available for DME Specific Peptides for CCT6B Gene
Domains & Families for CCT6B Gene
Gene Families for CCT6B Gene
- HGNC:
Protein Domains for CCT6B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCT6B Gene
Graphical View of Domain Structure for InterPro Entry
Q92526- Family:
-
- Belongs to the TCP-1 chaperonin family.
Function for CCT6B Gene
Molecular function for CCT6B Gene
- GENATLAS Biochemistry:
- chaperonin containing TCP1 (T complex protein 1),subunit 6B (zeta 2),testis specific,cytoplasmic,S cerevisiae TCP20 homolog,TF55/TCP-1 family
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008565 | protein transporter activity | TAS | 8812458 |
| GO:0044183 | protein binding involved in protein folding | IBA | -- |
| GO:0051082 | unfolded protein binding | IBA,TAS | -- |
Phenotypes for CCT6B Gene
- GenomeRNAi human phenotypes for CCT6B:
Animal Model Products
-
Taconic Biosciences Mouse Models for CCT6B
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCT6B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCT6B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT6B gene
- Search ViGene Biosciences for CCT6B
CRISPR Products
-
OriGene CRISPR knockouts for CCT6B
-
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miRNA for CCT6B Gene
- miRTarBase miRNAs that target CCT6B
miRNA Products
- Search ViGene Biosciences for CCT6B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCT6B
- Browse OriGene Inhibitory RNA Products For CCT6B
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT6B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCT6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT6B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCT6B
-
ViGene Biosciences adenoviral particle packaged cDNA for CCT6B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCT6B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT6B gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6B Gene
Localization for CCT6B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCT6B Gene
- Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005832 | chaperonin-containing T-complex | IBA | -- |
Pathways & Interactions for CCT6B Gene
Pathways by source for CCT6B Gene
1 GeneGo (Thomson Reuters) pathway for CCT6B Gene
Interacting Proteins for CCT6B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | 8812458 |
| GO:0006458 | de novo protein folding | IBA | -- |
| GO:0007283 | spermatogenesis | TAS | 8812458 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0051131 | chaperone-mediated protein complex assembly | TAS | 8812458 |
No data available for SIGNOR curated interactions for CCT6B Gene
Transcripts for CCT6B Gene
mRNA/cDNA for CCT6B Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (73) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCT6B Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCT6B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT6B
- GenScript: Design CRISPR guide RNA sequences for CCT6B
miRNA Products
- Search ViGene Biosciences for CCT6B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCT6B
- Browse OriGene Inhibitory RNA Products For CCT6B
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT6B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCT6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT6B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - |
Expression for CCT6B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Seminiferous Tubules
- Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CCT6B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT6B Gene
NURSA nuclear receptor signaling pathways regulating expression of CCT6B Gene:
CCT6BSOURCE GeneReport for Unigene cluster for CCT6B Gene:
Hs.73072mRNA Expression by UniProt/SwissProt for CCT6B Gene:
Q92526-TCPW_HUMANPrimer Products
-
OriGene qPCR primer pairs and template standards for CCT6B
-
OriGene qPCR primer pairs for CCT6B
No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT6B Gene
Orthologs for CCT6B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCT6B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCT6B 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | CCT6B 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Cct6b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cct6b 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCT6B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCT6 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6143 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cct6a 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Tcp-1zeta 35 |
|
OneToMany | |
| CG8231 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | cct-6 36 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CCT6 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11031 35 |
|
OneToMany |
- Species where no ortholog for CCT6B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CCT6B Gene
(7) SIMAP similar genes for CCT6B Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for CCT6B Gene
Variants for CCT6B Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000049411 | -- | 34,946,617(+) | TTATA(G/T)CAGCA | intron-variant | |
| rs1000096608 | -- | 34,934,598(+) | CCACT(A/T)AAGCT | intron-variant | |
| rs1000108026 | -- | 34,940,154(+) | CCTTT(A/G)ACCCA | intron-variant | |
| rs1000125341 | -- | 34,978,523(+) | GCCAA(C/T)ATCGT | intron-variant, upstream-variant-2KB | |
| rs1000173473 | -- | 34,947,631(+) | ATCTA(C/T)AGGAT | intron-variant |
Relevant External Links for CCT6B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCT6B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6B Gene
Disorders for CCT6B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pelvic varices |
|
|
Relevant External Links for CCT6B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCT6B
No data available for UniProtKB/Swiss-Prot and Genatlas for CCT6B Gene
Publications for CCT6B Gene
- Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PMID: 8812458) Ozaki K. … Nakamura Y. (Genomics 1996) 2 3 4 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. (PMID: 9013858) Kubota H. … Willison K.R. (FEBS Lett. 1997) 2 3 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for CCT6B Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for CCT6B
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- OriGene qPCR primer pairs and template standards for CCT6B
- OriGene qPCR primer pairs for CCT6B
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- GenScript: Design CRISPR guide RNA sequences for CCT6B
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- Novus Biologicals Antibodies for CCT6B
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- Novus Biologicals
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- Taconic Biosciences Mouse Models for CCT6B
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- antibodies-online Antibodies for CCT6B: See all 22
- antibodies-online Kits for CCT6B: See all 3
- antibodies-online Proteins for CCT6B: See all 4
- Search antibodies-online for peptides
- GeneTex CCT6B antibody for CCT6B
- Search GeneTex for Proteins for CCT6B
- ViGene Biosciences adenoviral particle packaged cDNA for CCT6B gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCT6B gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCT6B gene
- Search ViGene Biosciences for CCT6B
- Santa Cruz Biotechnology (SCBT) Antibodies for CCT6B
- Search Santa Cruz Biotechnology (SCBT) for CCT6B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCT6B
- Horizon Cell Lines for CCT6B
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCT6B
- VectorBuilder custom plasmid, inducible vectors for CCT6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT6B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCT6B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




