Aliases for CCT6B Gene
External Ids for CCT6B Gene
Previous GeneCards Identifiers for CCT6B Gene
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for CCT6B Gene
CCT6B (Chaperonin Containing TCP1 Subunit 6B) is a Protein Coding gene. Diseases associated with CCT6B include Pelvic Varices. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. GO annotations related to this gene include unfolded protein binding and protein transporter activity. An important paralog of this gene is CCT6A.
UniProtKB/Swiss-Prot for CCT6B Gene
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).