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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT6A Gene

protein-coding   GIFtS: 62
GCID: GC07P056086

chaperonin containing TCP1, subunit 6A (zeta 1)


(Previous symbol: CCT6)
 Explore 13 diseases affiliated with
CCT6A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCT6A    

Aliases
for CCT6A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chaperonin Containing TCP1, Subunit 6A (Zeta 1)1 2     CCT-Zeta1
CCT61 2 3     MoDP-22
HTR31 2 3     Acute Morphine Dependence Related Protein 22
Cctz1 2     Amino Acid Transport Defect-Complementing2
TCP201 2     Chaperonin Containing T-Complex Subunit 62
TCPZ1 2     Histidine Transport Regulator 32
TTCP201 2     T-Complex Protein 1 Subunit Zeta2
Acute Morphine Dependence-Related Protein 22 3     T-Complex Protein 1, Zeta Subunit2
CCT-Zeta-11     CCTZ3
TCP-1-Zeta1     Tcp203

External Ids:    HGNC: 16201   Entrez Gene: 9082   Ensembl: ENSG000001467317   OMIM: 1046135   UniProtKB: P402273   

Export aliases for CCT6A gene to outside databases

Previous GC identifers: GC07P055583 GC07P055827 GC07P055861 GC07P055893


Summaries
for CCT6A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCT6A:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex
(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each
containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in
an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional
splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes
of this gene have been located. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in
the folding of actin and tubulin

Gene Wiki entry for CCT6A


Genomic Views
for CCT6A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_033968.6  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT6A gene promoter:
         GR   AML1a   p53   CREB   IRF-2   deltaCREB   SEF-1 (1)   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCT6A promoter sequence
   Search SABiosciences Chromatin IP Primers for CCT6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

CCT6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT6A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056086:  view genomic region     (about GC identifiers)

Start:
 56,119,323 bp from pter      End:
 56,131,682 bp from pter
Size:
 12,360 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 56,123,625-56,135,929     

Proteins
for CCT6A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227 (See protein sequence)
Recommended Name: T-complex protein 1 subunit zeta  
Size: 531 amino acids; 58024 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA58676.1; Type=Erroneous initiation; Sequence=BU540578; Type=Miscellaneous discrepancy;
Note=Several sequencing errors;
Secondary accessions: A6NCD2 Q3KP28 Q75LP4 Q96S46
Alternative splicing: 2 isoforms:  P40227-1   P40227-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT6A: NX_P40227

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40227

    • CCT6A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009186.1  NP_001753.1  

    ENSEMBL proteins: 
     ENSP00000275603   ENSP00000352019   ENSP00000438488  
    Reactome Protein details: P40227
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): CCT6A
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    Uscn Proteins for CCT6A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8034610
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--
    GO:0005874microtubule IDA--


    CCT6A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CCT6A

    Protein Domains /
    Families
    for CCT6A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCT6A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR002423 Cpn60/TCP-1
     IPR012722 Chap_CCT_zeta

    Graphical View of Domain Structure for InterPro Entry P40227

    ProtoNet protein and cluster: P40227

    2 Blocks protein families:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
    Similarity: Belongs to the TCP-1 chaperonin family


    Function
    for CCT6A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in
    the folding of actin and tubulin

         Genatlas biochemistry entry for CCT6A:
    chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae
    homolog,TF55/TCP-1 family

    miRNA
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    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: CCT6A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--


    CCT6A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CCT6A:
     Decreased viability of wild-ty  Synthetic lethal with Ras 


    Pathways & Interactions
    for CCT6A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of tubulin folding intermediates by CCT/TriC
    		Formation of tubulin folding intermediates by CCT/TriC1.00
    		Prefoldin mediated transfer of substrate to CCT/TriC0.70
    		Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    		Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    		Chaperonin-mediated protein folding1.00
    		Association of TriC/CCT with target proteins during biosynthesis0.60
    		Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    		Cell cycle Role of APC in cell cycle regulation1.00
    		Cell cycle_Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCT6A
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT6A
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT6A (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1001 Interacting proteins for CCT6A (P402272, 3 ENSP000002756034) via UniProtKB, MINT, STRING, and/or I2D (see all 1001)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT4P509912, 3, ENSP000003779584MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000377958
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000258091
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    EIF3IQ133472, 3, ENSP000003626884MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000362688
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--


    CCT6A for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCT6A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT6A
    Search CenterWatch for drugs/clinical trials and news about CCT6A / TCPZ 

    Transcripts
    for CCT6A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCT6A gene (2 alternative transcripts): 
    NM_001009186.1  NM_001762.3  

    Unigene Cluster for CCT6A:

    Chaperonin containing TCP1, subunit 6A (zeta 1)
    Hs.82916  [show with all ESTs]
    Unigene Representative Sequence: NM_001762
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275603(uc003trl.1 uc011kcu.1) ENST00000335503(uc003trm.1)
    ENST00000493855 ENST00000482776 ENST00000492618 ENST00000466572 ENST00000462133
    ENST00000494736 ENST00000466479 ENST00000540286

    miRNA
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    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: CCT6A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT6A (see all 7)
    OriGene shRNA RFP: CCT6A
    OriGene siRNA: CCT6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT6A
    Clone
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    Additional cDNA sequence: 

    AB063318.1 AB209728.1 AF385084.1 AK297751.1 AK298371.1 AK313819.1 AK316230.1 AM295155.1 
    BC106941.1 BC106942.1 L27706.1 M94083.1 

    24/44 DOTS entries (see all 44):

    DT.97860745  DT.100039052  DT.86999971  DT.121122465  DT.100676262  DT.100674808  DT.121122337  DT.92465140 
    DT.100674814  DT.121122230  DT.121122218  DT.95289676  DT.121122255  DT.121122480  DT.100799093  DT.121122316 
    DT.121122357  DT.95227110  DT.99990326  DT.100807148  DT.91729560  DT.92465148  DT.92465157  DT.95227200 

    24/1112 AceView cDNA sequences (see all 1112):

    BQ687014 AI089484 BF026741 BE277276 BM761679 BM460607 BQ030353 AA857873 
    BQ051163 BQ213866 BM480009 CA443947 BU679755 AA278281 CA438781 AI610145 
    BQ689316 AI280553 AI972550 AI128002 BM905887 BM791112 CB132328 AA383147 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:                                                                                      -                 -     -                           
    SP2:                    -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                        -     -                           


    ECgene alternative splicing isoforms for CCT6A

    Expression
    for CCT6A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAGATAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCT6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT6A

    SOURCE GeneReport for Unigene cluster: Hs.82916
        SABiosciences Expression via Pathway-Focused PCR Array including CCT6A: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CCT6A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT6A gene from 8/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCT6A1 chaperonin containing TCP1, subunit 6A (zeta 1) 81.54(n)
    89.98(a)    		   417541  NM_001006216.1  NP_001006216.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.15192 Xenopus laevis transcribed sequence with moderate similarity more 78.13(n)    BQ731892.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cct6a2 chaperonin containing TCP1, subunit 6A (zeta 1) 76.27(n)   116994  BC044393.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG82313
    Tcp-1zeta1    		 chaperonin ATPase3
    T-cp1zeta1    		 69(a)3
    63.72(n)1
    69.3(a)1    		   13E143
    325181  NM_132838.21  NP_573066.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cct-61 , 3 Expression: embryo3
    Protein CCT-61    		 66(a)3
    60.95(n)1
    68(a)1    		   III(5925494-5926671)3
    1758191  NM_171135.51  NP_741153.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CCT6(YDR188W)4
    CCT61    		 Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct6p1    		 59.09(n)1
    58.14(a)1    		   4(836421-838061)4
    8517681, 4  NP_010474.31  NP_010474.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G160701 TCP-1/cpn60 chaperonin family protein 61.85(n)
    63.12(a)    		   831464  NM_121612.2  NP_197111.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.49902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.47(n)    AK065883.1 


    ENSEMBL Gene Tree for CCT6A (if available)
    TreeFam Gene Tree for CCT6A (if available) 

    Paralogs
    for CCT6A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT6A gene
    CCT6B2  
    7 SIMAP similar genes for CCT6A using alignment to 3 protein entries:     TCPZ_HUMAN (see all proteins):
    CCT6B    CCT3    CCT2    TCP1    CCT5    CCT4
    CCT7

    CCT6A for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CCT6A
    PGOHUM00000242475 PGOHUM00000238300 PGOHUM00000233372 PGOHUM00000233383


    Genomic Variants
    for CCT6A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 NCBI SNPs in CCT6A are shown (see all 285)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs44242121,2
    		C,F,A,H,--56117409(+) TACAGG/ATGTGA 3 -- int1 us2k116Minor allele frequency- A:0.25NS EA NA WA 1976
    rs2016968381,2
    		--56117446(+) TTATT-/ATTTTT 3 -- us2k1 int10--------
    rs1998492721,2
    		--56117448(+) TTATT-/ATTTTT 3 -- us2k1 int10--------
    rs1485277541,2
    		--56117532(+) GAGTTC/TAAGCA 3 -- us2k1 int10--------
    rs800796231,2
    		--56117537(+) CAAGCG/AATTCT 3 -- us2k1 int11Minor allele frequency- A:0.00NA 2
    rs44271221,2
    		C,F,A,--56117707(+) TACAAG/ACGTGC 3 -- us2k1 int17Minor allele frequency- A:0.27NA WA EA 366
    rs1925741411,2
    		--56117709(+) CAAGCA/GTGCGC 3 -- us2k1 int10--------
    rs1398384761,2
    		--56117808(+) AGTCTC/TCTATC 3 -- us2k1 int10--------
    rs2020236091,2
    		--56117843(+) AGATG-/TTTTTT 3 -- int1 us2k10--------
    rs1840017651,2
    		--56118098(+) GGATCA/TCAGAC 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for CCT6A (56119323 - 56131682 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CCT6A
         1 CNV: 64828

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT6A
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT6A

    Disorders / Diseases
    for CCT6A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCT6A for disorders           About GeneDecksing

    OMIM gene information: 104613    OMIM disorders: --

    13 diseases for CCT6A:    About MalaCards
    morphine dependence    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3
    squamous cell carcinoma    endocarditis    cerebritis    endometrial cancer
    pneumonia    tuberculosis    carcinoma    malaria
    mycobacterium tuberculosis


    Export disorders for CCT6A gene to outside databases

    Publications
    for CCT6A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT6A gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with CCT6A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PubMed id 8034610)1, 2, 3, 9 Li W.Z....Sherman F. (1994)
    2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PubMed id 1352881)1, 2, 3 Segel G.B....Sherman F. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    External Searches for CCT6A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCT6A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 908 HGNC: 1620 AceView: CCT6AandSUMF2 Ensembl:ENSG00000146731 euGenes: HUgn908
    ECgene: CCT6A H-InvDB: CCT6A

    Other Databases showing CCT6A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCT6A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT6A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCT6A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCT6A gene:
    Search GeneIP for patents involving CCT6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCT6A gene

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    About This Section

     
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