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Aliases for CCT6A Gene

Aliases for CCT6A Gene

  • Chaperonin Containing TCP1 Subunit 6A 2 3
  • Chaperonin Containing TCP1, Subunit 6A (Zeta 1) 2 3 5
  • Acute Morphine Dependence-Related Protein 2 3 4
  • CCT-Zeta-1 3 4
  • TCP-1-Zeta 3 4
  • TCP20 3 4
  • Cctz 3 4
  • CCT6 3 4
  • HTR3 3 4
  • Acute Morphine Dependence Related Protein 2 3
  • Amino Acid Transport Defect-Complementing 3
  • Chaperonin Containing T-Complex Subunit 6 3
  • T-Complex Protein 1, Zeta Subunit 3
  • Histidine Transport Regulator 3 3
  • CCT-Zeta 3
  • MoDP-2 3
  • TTCP20 3
  • TCPZ 3

External Ids for CCT6A Gene

Previous HGNC Symbols for CCT6A Gene

  • CCT6

Previous GeneCards Identifiers for CCT6A Gene

  • GC07P055583
  • GC07P055827
  • GC07P055861
  • GC07P055893
  • GC07P056086

Summaries for CCT6A Gene

Entrez Gene Summary for CCT6A Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

GeneCards Summary for CCT6A Gene

CCT6A (Chaperonin Containing TCP1 Subunit 6A) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and G-protein activation. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is CCT6B.

UniProtKB/Swiss-Prot for CCT6A Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6A Gene

Genomics for CCT6A Gene

Regulatory Elements for CCT6A Gene

Enhancers for CCT6A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCT6A on UCSC Golden Path with GeneCards custom track

Promoters for CCT6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT6A on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT6A Gene

Chromosome:
7
Start:
56,051,630 bp from pter
End:
56,063,989 bp from pter
Size:
12,360 bases
Orientation:
Plus strand

Genomic View for CCT6A Gene

Genes around CCT6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6A Gene

Proteins for CCT6A Gene

  • Protein details for CCT6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40227-TCPZ_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta
    Protein Accession:
    P40227
    Secondary Accessions:
    • A6NCD2
    • Q3KP28
    • Q75LP4
    • Q96S46

    Protein attributes for CCT6A Gene

    Size:
    531 amino acids
    Molecular mass:
    58024 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.
    SequenceCaution:
    • Sequence=AAA58676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BU540578; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6A Gene

Proteomics data for CCT6A Gene at MOPED

Post-translational modifications for CCT6A Gene

  • Ubiquitination at Lys 10, Lys 58, Lys 127, Lys 129, Lys 138, Lys 251, Lys 280, Lys 295, Lys 307, Lys 377, Lys 381, Lys 399, and Lys 530
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT6A Gene

Domains & Families for CCT6A Gene

Gene Families for CCT6A Gene

Suggested Antigen Peptide Sequences for CCT6A Gene

Graphical View of Domain Structure for InterPro Entry

P40227

UniProtKB/Swiss-Prot:

TCPZ_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6A: view

Function for CCT6A Gene

Molecular function for CCT6A Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with CCT6A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCT6A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT6A Gene

Localization for CCT6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT6A Gene COMPARTMENTS Subcellular localization image for CCT6A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CCT6A Gene

Pathways & Interactions for CCT6A Gene

genes like me logo Genes that share pathways with CCT6A: view

Gene Ontology (GO) - Biological Process for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050821 protein stabilization IMP 25467444
genes like me logo Genes that share ontologies with CCT6A: view

No data available for SIGNOR curated interactions for CCT6A Gene

Drugs & Compounds for CCT6A Gene

No Compound Related Data Available

Transcripts for CCT6A Gene

Unigene Clusters for CCT6A Gene

Chaperonin containing TCP1, subunit 6A (zeta 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7: -
SP8:

Relevant External Links for CCT6A Gene

GeneLoc Exon Structure for
CCT6A
ECgene alternative splicing isoforms for
CCT6A

Expression for CCT6A Gene

mRNA expression in normal human tissues for CCT6A Gene

Protein differential expression in normal tissues from HIPED for CCT6A Gene

This gene is overexpressed in Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT6A Gene



SOURCE GeneReport for Unigene cluster for CCT6A Gene Hs.82916

genes like me logo Genes that share expression patterns with CCT6A: view

Protein tissue co-expression partners for CCT6A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT6A Gene

Orthologs for CCT6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT6A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT6A 35
  • 92.59 (n)
  • 97.18 (a)
CCT6A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT6A 35
  • 89.96 (n)
  • 93.79 (a)
CCT6A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct6a 35
  • 88.76 (n)
  • 96.8 (a)
Cct6a 16
Cct6a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT6A 35
  • 99.5 (n)
  • 100 (a)
CCT6A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct6a 35
  • 89.01 (n)
  • 96.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CCT6A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCT6A 35
  • 81.54 (n)
  • 89.98 (a)
CCT6 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cct6a 35
  • 77.9 (n)
  • 88.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1519 35
zebrafish
(Danio rerio)
Actinopterygii cct6a 35
  • 74.83 (n)
  • 87.57 (a)
cct6a 36
  • 87 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8765 35
fruit fly
(Drosophila melanogaster)
Insecta CG8231 37
  • 69 (a)
Tcp-1zeta 35
  • 63.72 (n)
  • 69.3 (a)
Tcp-1zeta 36
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003477 35
  • 62.02 (n)
  • 68.74 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-6 37
  • 66 (a)
cct-6 35
  • 60.95 (n)
  • 68 (a)
cct-6 36
  • 65 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL121W 35
  • 57.95 (n)
  • 59.47 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18458g 35
  • 59.03 (n)
  • 59.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 35
  • 59.09 (n)
  • 58.14 (a)
CCT6 36
  • 56 (a)
OneToMany
CCT6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16070 35
  • 61.98 (n)
  • 63.12 (a)
soybean
(Glycine max)
eudicotyledons Gma.4814 35
barley
(Hordeum vulgare)
Liliopsida Hv.482 35
rice
(Oryza sativa)
Liliopsida Os.4990 35
Os05g0147400 35
  • 62.18 (n)
  • 64.33 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6733 35
corn
(Zea mays)
Liliopsida Zm.6782 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2074 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09709 35
  • 60.23 (n)
  • 65.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct6 35
  • 60.66 (n)
  • 63.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 36
  • 73 (a)
OneToMany
Species with no ortholog for CCT6A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT6A Gene

ENSEMBL:
Gene Tree for CCT6A (if available)
TreeFam:
Gene Tree for CCT6A (if available)

Paralogs for CCT6A Gene

Paralogs for CCT6A Gene

(7) SIMAP similar genes for CCT6A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT6A Gene

genes like me logo Genes that share paralogs with CCT6A: view

Variants for CCT6A Gene

Sequence variations from dbSNP and Humsavar for CCT6A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs33922584 - 56,058,064(+) TGCAT(A/G)CATCC reference, missense
rs6958480 -- 56,055,205(+) GGAGG(C/T)GGAGG intron-variant
rs6960348 -- 56,056,547(+) GGGAA(A/G)CCCCG intron-variant
rs12671494 -- 56,057,834(+) CAAGA(C/T)GGCAC intron-variant
rs13229704 -- 56,055,209(+) GTGGA(C/G)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6A Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
esv2734448 CNV Deletion 23290073

Variation tolerance for CCT6A Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCT6A Gene

Disorders for CCT6A Gene

Relevant External Links for CCT6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT6A

No disorders were found for CCT6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT6A Gene

Publications for CCT6A Gene

  1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PMID: 8034610) Li W.-Z. … Segel G.B. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PMID: 1352881) Segel G.B. … Sherman F. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for CCT6A Gene

Sources for CCT6A Gene

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