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CCT6A Gene

protein-coding   GIFtS: 64
GCID: GC07P056086

Chaperonin Containing TCP1, Subunit 6A (Zeta 1)


(Previous symbol: CCT6)
  See CCT6A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 6A (Zeta 1)1 2     TCPZ2
CCT61 2 3 5     TTCP202
HTR32 3 5     Acute Morphine Dependence Related Protein 22
Acute Morphine Dependence-Related Protein 22 3     Amino Acid Transport Defect-Complementing2
CCT-zeta-12 3     Chaperonin Containing T-Complex Subunit 62
TCP-1-zeta2 3     Histidine Transport Regulator 32
TCP202 5     T-Complex Protein 1 Subunit Zeta2
CCT-zeta2     T-Complex Protein 1, Zeta Subunit2
Cctz2     CCTZ3
MoDP-22     Tcp203

External Ids:    HGNC: 16201   Entrez Gene: 9082   Ensembl: ENSG000001467317   OMIM: 1046135   UniProtKB: P402273   

Export aliases for CCT6A gene to outside databases

Previous GC identifers: GC07P055583 GC07P055827 GC07P055861 GC07P055893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT6A Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition,
several pseudogenes of this gene have been located. (provided by RefSeq, Jun 2010)

GeneCards Summary for CCT6A Gene:
CCT6A (chaperonin containing TCP1, subunit 6A (zeta 1)) is a protein-coding gene. Diseases associated with CCT6A include morphine dependence. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT6B.

UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT6A gene promoter:
         GR   AML1a   p53   CREB   IRF-2   deltaCREB   SEF-1 (1)   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCT6A promoter sequence
   Search Chromatin IP Primers for CCT6A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

CCT6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT6A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056086:  view genomic region     (about GC identifiers)

Start:
56,119,323 bp from pter      End:
56,131,682 bp from pter
Size:
12,360 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 56,123,625-56,135,929     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227 (See protein sequence)
Recommended Name: T-complex protein 1 subunit zeta  
Size: 531 amino acids; 58024 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG
Sequence caution: Sequence=AAA58676.1; Type=Erroneous initiation; Sequence=BU540578; Type=Miscellaneous
discrepancy; Note=Several sequencing errors;
Secondary accessions: A6NCD2 Q3KP28 Q75LP4 Q96S46
Alternative splicing: 2 isoforms:  P40227-1   P40227-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT6A: NX_P40227

Explore proteomics data for CCT6A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys10, Lys41, Lys58, Lys127, Lys129, Lys138, Lys199, Lys251, Lys280,
                                 Lys287, Lys295, Lys307, Lys377, Lys381, Lys399, Lys530
  • Modification sites at PhosphoSitePlus

  • See CCT6A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009186.1  NP_001753.1  

    ENSEMBL proteins: 
     ENSP00000275603   ENSP00000352019   ENSP00000438488  
    Reactome Protein details: P40227

    CCT6A Human Recombinant Protein Products:

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    Novus Biologicals CCT6A Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT6A

     
    Search eBioscience for Proteins for CCT6A 

     
    antibodies-online proteins for CCT6A (2 products) 

     
    antibodies-online peptides for CCT6A

    CCT6A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for CCT6A (15 products) 

    CCT6A Assay Products:

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    Cloud-Clone Corp. CLIAs for CCT6A
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    antibodies-online kits for CCT6A (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P40227

    ProtoNet protein and cluster: P40227

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
    Similarity: Belongs to the TCP-1 chaperonin family


    Find genes that share domains with CCT6A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPZ_HUMAN, P40227
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
    vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT6A:
    chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae
    homolog,TF55/TCP-1 family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with CCT6A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCT6A:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCT6A

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT6A:
    hsa-mir-30e-5p (MIRT044158), hsa-mir-3663-3p (MIRT052868), hsa-mir-324-3p (MIRT042874), hsa-mir-149-5p (MIRT045502), hsa-mir-32-5p (MIRT028359), hsa-mir-18a-5p (MIRT050689), hsa-mir-17-5p (MIRT050996), hsa-mir-186-5p (MIRT045101)

    Block miRNA regulation of human, mouse, rat CCT6A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCT6A (see all 23):
    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCCT6A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT6A
    Predesigned siRNA for gene silencing in human, mouse, rat CCT6A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCT6A (NM_001762)
    Sino Biological Human cDNA Clone for CCT6A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT6A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT6A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPZ_HUMAN, P40227: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm TAS8034610
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    Find genes that share ontologies with CCT6A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT6A About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with CCT6A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT6A
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT6A
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Array including CCT6A: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCT6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT6A (P402272, 3 ENSP000002756034) via UniProtKB, MINT, STRING, and/or I2D (see all 1153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT2P783712, 3, ENSP000002993004MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000299300
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000258091
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    ABCF3Q9NUQ82, 3, ENSP000004114714MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000411471
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with CCT6A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT6A (TCPZ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCT6A gene (2 alternative transcripts): 
    NM_001009186.1  NM_001762.3  

    Unigene Cluster for CCT6A:

    Chaperonin containing TCP1, subunit 6A (zeta 1)
    Hs.82916  [show with all ESTs]
    Unigene Representative Sequence: NM_001762
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275603(uc003trl.1 uc011kcu.1) ENST00000335503(uc003trm.1)
    ENST00000493855 ENST00000482776 ENST00000492618 ENST00000466572 ENST00000462133
    ENST00000494736 ENST00000466479 ENST00000540286
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCT6A (see all 23):
    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCCT6A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CCT6A
      QuantiFast Probe-based Assays in human, mouse, rat CCT6A

    Additional mRNA sequence: 

    AB063318.1 AB209728.1 AF385084.1 AK297751.1 AK298371.1 AK313819.1 AK316230.1 AM295155.1 
    BC106941.1 BC106942.1 L27706.1 M94083.1 

    Selected DOTS entries (see all 44):

    DT.97860745  DT.100039052  DT.86999971  DT.121122465  DT.100676262  DT.100674808  DT.121122337  DT.92465140 
    DT.100674814  DT.121122230  DT.121122218  DT.95289676  DT.121122255  DT.121122480  DT.100799093  DT.121122316 
    DT.121122357  DT.95227110  DT.99990326  DT.100807148  DT.91729560  DT.92465148  DT.92465157  DT.95227200 

    Selected AceView cDNA sequences (see all 1112):

    AI969574 BQ056368 BF969343 BQ216660 CD105975 CR602256 BM466076 CA445298 
    AA970264 BU521370 CD172248 AI359386 F09732 AA988867 CA417653 AI300483 
    CR626783 BU733749 CA447296 BM702654 BU197095 AI570514 BQ422674 AI284003 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:                                                                                      -                 -     -                           
    SP2:                    -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                        -     -                           


    ECgene alternative splicing isoforms for CCT6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCT6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGATAAGC
    CCT6A Expression
    About this image


    CCT6A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CCT6A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT6A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82916
        Pathway & Disease-focused RT2 Profiler PCR Array including CCT6A: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT6A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT6A gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct6a1 , 5 chaperonin containing Tcp1, subunit 6a (zeta)1, 5 88.76(n)1
    96.8(a)1
      5 (68.26 cM)5
    124661  NM_009838.21  NP_033968.11 
     1297874395 
    chicken
    (Gallus gallus)
    Aves CCT6A1 chaperonin containing TCP1, subunit 6A (zeta 1) 81.54(n)
    89.98(a)
      417541  NM_001006216.1  NP_001006216.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.15192 Xenopus laevis transcribed sequence with moderate similarity more 78.13(n)    BQ731892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct6a2 chaperonin containing TCP1, subunit 6A (zeta 1) 76.27(n)   116994  BC044393.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82313
    Tcp-1zeta1
    chaperonin ATPase3
    T-cp1zeta1
    69(a)3
    63.72(n)1
    69.3(a)1
      13E143
    325181  NM_132838.21  NP_573066.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-61 , 3 Expression: embryo3
    cct-61
    66(a)3
    60.95(n)1
    68(a)1
      III(5925494-5926671)3
    1758191  NM_171135.61  NP_741153.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT6(YDR188W)4
    CCT61
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    CCT61
    59.09(n)1
    58.14(a)1
      4(836421-838061)4
    8517681, 4  NP_010474.31  NP_010474.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G160701 AT5G16070 61.98(n)
    63.12(a)
      831464  NM_121612.2  NP_197111.2 
    rice
    (Oryza sativa)
    Liliopsida Os.49902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.47(n)    AK065883.1 


    ENSEMBL Gene Tree for CCT6A (if available)
    TreeFam Gene Tree for CCT6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT6A gene
    CCT6B2  
    7 SIMAP similar genes for CCT6A using alignment to 3 protein entries:     TCPZ_HUMAN (see all proteins):
    CCT6B    CCT3    CCT2    TCP1    CCT5    CCT4
    CCT7

    Find genes that share paralogs with CCT6A           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for CCT6A
    PGOHUM00000242475 PGOHUM00000238300 PGOHUM00000233372 PGOHUM00000233383


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT6A (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449218431,2
    --56121292(+) AAATAC/GAAAAA 2 -- int10--------
    rs102550491,2
    C,F--56121304(+) TAGCCA/GGGTGT 2 -- int110Minor allele frequency- G:0.41NA WA CSA EA 371
    rs1387486001,2
    --56121319(+) CTGCAC/TGCCTG 2 -- int10--------
    rs1865750121,2
    --56121522(+) TTGAAC/TATTTA 2 -- int10--------
    rs1918589101,2
    --56121682(+) CTACAA/GAAATA 2 -- int10--------
    rs1419819841,2
    C--56121701(+) GTGTGC/TGCCCT 2 -- int10--------
    rs1839457161,2
    C--56121777(+) ATTATG/TTGTTA 2 -- int10--------
    rs1176003821,2
    F--56121821(+) CTTCTA/GCTGAG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1900215311,2
    --56121826(+) ACTGAG/TCCTCA 2 -- int10--------
    rs1177342511,2
    C,F--56121833(+) CTCAAG/ACTTCC 2 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for CCT6A (56119323 - 56131682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCT6A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    esv28230CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT6A
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT6A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104613    OMIM disorders: --

    1 disease for CCT6A:    
    About MalaCards
    morphine dependence


    Find genes that share disorders with CCT6A           About GenesLikeMe


    Export disorders for CCT6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT6A gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with CCT6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PubMed id 8034610)1, 2, 3, 9 Li W.-Z.... Segel G.B. (J. Biol. Chem. 1994)
    2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PubMed id 1352881)1, 2, 3 Segel G.B....Sherman F. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 908 HGNC: 1620 AceView: CCT6AandSUMF2 Ensembl:ENSG00000146731 euGenes: HUgn908
    ECgene: CCT6A H-InvDB: CCT6A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCT6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCT6A gene:
    Search GeneIP for patents involving CCT6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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