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Aliases for CCT6A Gene

Aliases for CCT6A Gene

  • Chaperonin Containing TCP1, Subunit 6A (Zeta 1) 2 3
  • TCP20 3 4 6
  • HTR3 3 4 6
  • CCT6 3 4 6
  • Acute Morphine Dependence-Related Protein 2 3 4
  • CCT-Zeta-1 3 4
  • TCP-1-Zeta 3 4
  • Cctz 3 4
  • Acute Morphine Dependence Related Protein 2 3
  • Amino Acid Transport Defect-Complementing 3
  • Chaperonin Containing T-Complex Subunit 6 3
  • T-Complex Protein 1, Zeta Subunit 3
  • T-Complex Protein 1 Subunit Zeta 3
  • Histidine Transport Regulator 3 3
  • CCT-Zeta 3
  • MoDP-2 3
  • TTCP20 3
  • TCPZ 3

External Ids for CCT6A Gene

Previous HGNC Symbols for CCT6A Gene

  • CCT6

Previous GeneCards Identifiers for CCT6A Gene

  • GC07P055583
  • GC07P055827
  • GC07P055861
  • GC07P055893
  • GC07P056086

Summaries for CCT6A Gene

Entrez Gene Summary for CCT6A Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

GeneCards Summary for CCT6A Gene

CCT6A (Chaperonin Containing TCP1, Subunit 6A (Zeta 1)) is a Protein Coding gene. Diseases associated with CCT6A include morphine dependence. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT6B.

UniProtKB/Swiss-Prot for CCT6A Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT6A Gene

Genomics for CCT6A Gene

Regulatory Elements for CCT6A Gene

Genomic Location for CCT6A Gene

Start:
56,051,630 bp from pter
End:
56,063,989 bp from pter
Size:
12,360 bases
Orientation:
Plus strand

Genomic View for CCT6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT6A Gene

Proteins for CCT6A Gene

  • Protein details for CCT6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40227-TCPZ_HUMAN
    Recommended name:
    T-complex protein 1 subunit zeta
    Protein Accession:
    P40227
    Secondary Accessions:
    • A6NCD2
    • Q3KP28
    • Q75LP4
    • Q96S46

    Protein attributes for CCT6A Gene

    Size:
    531 amino acids
    Molecular mass:
    58024 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.
    SequenceCaution:
    • Sequence=AAA58676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BU540578; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT6A Gene

Proteomics data for CCT6A Gene at MOPED

Post-translational modifications for CCT6A Gene

  • Ubiquitination at Lys5, Lys10, Lys41, Lys58, Lys127, Lys129, Lys138, Lys199, Lys251, Lys280, Lys287, Lys295, Lys307, Lys377, Lys381, Lys399, and Lys530
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT6A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT6A Gene

Domains for CCT6A Gene

Gene Families for CCT6A Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

Suggested Antigen Peptide Sequences for CCT6A Gene

Graphical View of Domain Structure for InterPro Entry

P40227

UniProtKB/Swiss-Prot:

TCPZ_HUMAN :
  • P40227
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT6A: view

Function for CCT6A Gene

Molecular function for CCT6A Gene

GENATLAS Biochemistry: chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae homolog,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Ontology (GO) - Molecular Function for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT6A: view

Phenotypes for CCT6A Gene

genes like me logo Genes that share phenotypes with CCT6A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT6A Gene

Localization for CCT6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT6A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT6A Gene COMPARTMENTS Subcellular localization image for CCT6A gene
Compartment Confidence
cytoskeleton 5
cytosol 4
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm TAS 8034610
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
genes like me logo Genes that share ontologies with CCT6A: view

Pathways for CCT6A Gene

genes like me logo Genes that share pathways with CCT6A: view

Gene Ontology (GO) - Biological Process for CCT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT6A: view

Transcripts for CCT6A Gene

Unigene Clusters for CCT6A Gene

Chaperonin containing TCP1, subunit 6A (zeta 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7: -
SP8:

Relevant External Links for CCT6A Gene

GeneLoc Exon Structure for
CCT6A
ECgene alternative splicing isoforms for
CCT6A

Expression for CCT6A Gene

mRNA expression in normal human tissues for CCT6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT6A Gene

SOURCE GeneReport for Unigene cluster for CCT6A Gene Hs.82916

genes like me logo Genes that share expressions with CCT6A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT6A Gene

Orthologs for CCT6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT6A 35
  • 99.5 (n)
  • 100 (a)
CCT6A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT6A 35
  • 92.59 (n)
  • 97.18 (a)
CCT6A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT6A 35
  • 89.96 (n)
  • 93.79 (a)
CCT6A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct6a 35
  • 88.76 (n)
  • 96.8 (a)
Cct6a 16
Cct6a 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT6A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cct6a 35
  • 89.01 (n)
  • 96.8 (a)
chicken
(Gallus gallus)
Aves CCT6 36
  • 90 (a)
OneToMany
CCT6A 35
  • 81.54 (n)
  • 89.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1519 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cct6a 35
  • 77.9 (n)
  • 88.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8765 35
zebrafish
(Danio rerio)
Actinopterygii cct6a 35
  • 74.83 (n)
  • 87.57 (a)
cct6a 36
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003477 35
  • 62.02 (n)
  • 68.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tcp-1zeta 35
  • 63.72 (n)
  • 69.3 (a)
Tcp-1zeta 36
  • 69 (a)
OneToMany
CG8231 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-6 35
  • 60.95 (n)
  • 68 (a)
cct-6 36
  • 65 (a)
OneToMany
cct-6 37
  • 66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL121W 35
  • 57.95 (n)
  • 59.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT6 35
  • 59.09 (n)
  • 58.14 (a)
CCT6 36
  • 56 (a)
OneToMany
CCT6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18458g 35
  • 59.03 (n)
  • 59.47 (a)
soybean
(Glycine max)
eudicotyledons Gma.4814 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16070 35
  • 61.98 (n)
  • 63.12 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.482 35
corn
(Zea mays)
Liliopsida Zm.6782 35
rice
(Oryza sativa)
Liliopsida Os.4990 35
Os05g0147400 35
  • 62.18 (n)
  • 64.33 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6733 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09709 35
  • 60.23 (n)
  • 65.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct6 35
  • 60.66 (n)
  • 63.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2074 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11031 36
  • 73 (a)
OneToMany
Species with no ortholog for CCT6A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT6A Gene

ENSEMBL:
Gene Tree for CCT6A (if available)
TreeFam:
Gene Tree for CCT6A (if available)

Paralogs for CCT6A Gene

Paralogs for CCT6A Gene

Selected SIMAP similar genes for CCT6A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT6A Gene

genes like me logo Genes that share paralogs with CCT6A: view

Variants for CCT6A Gene

Sequence variations from dbSNP and Humsavar for CCT6A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4927 -- 56,061,818(+) GAATC(A/G)GGTCA reference, synonymous-codon
rs3209777 -- 56,061,724(+) TCTCA(A/G)GAATT intron-variant
rs6593297 -- 56,054,365(+) TACTT(A/T)CAGCA intron-variant
rs6958480 -- 56,055,205(+) GGAGG(C/T)GGAGG intron-variant
rs6960348 -- 56,056,547(+) GGGAA(A/G)CCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT6A Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
esv2734448 CNV Deletion 23290073

Relevant External Links for CCT6A Gene

HapMap Linkage Disequilibrium report
CCT6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT6A Gene

Disorders for CCT6A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CCT6A Gene including...

Search for CCT6A Gene in MalaCards »
genes like me logo Genes that share disorders with CCT6A: view

No data available for UniProtKB/Swiss-Prot for CCT6A Gene

Publications for CCT6A Gene

  1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PMID: 8034610) Li W.-Z. … Segel G.B. (J. Biol. Chem. 1994) 2 3 4 23
  2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PMID: 1352881) Segel G.B. … Sherman F. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4

Products for CCT6A Gene

Sources for CCT6A Gene

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