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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT6A Gene

protein-coding   GIFtS: 63
GCID: GC07P056086

Chaperonin Containing TCP1, Subunit 6A (Zeta 1)


(Previous symbol: CCT6)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chaperonin Containing TCP1, Subunit 6A (Zeta 1)1 2     TCPZ2
CCT61 2 3     TTCP202
Acute Morphine Dependence-Related Protein 22 3     Acute Morphine Dependence Related Protein 22
CCT-zeta-12 3     Amino Acid Transport Defect-Complementing2
HTR32 3     Chaperonin Containing T-Complex Subunit 62
TCP-1-zeta2 3     Histidine Transport Regulator 32
CCT-zeta2     T-Complex Protein 1 Subunit Zeta2
Cctz2     T-Complex Protein 1, Zeta Subunit2
MoDP-22     CCTZ3
TCP202     Tcp203

External Ids:    HGNC: 16201   Entrez Gene: 9082   Ensembl: ENSG000001467317   OMIM: 1046135   UniProtKB: P402273   

Export aliases for CCT6A gene to outside databases

Previous GC identifers: GC07P055583 GC07P055827 GC07P055861 GC07P055893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT6A Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition,
several pseudogenes of this gene have been located. (provided by RefSeq, Jun 2010)

GeneCards Summary for CCT6A Gene: 
CCT6A (chaperonin containing TCP1, subunit 6A (zeta 1)) is a protein-coding gene. Diseases associated with CCT6A include morphine dependence, and cerebral cavernous malformations 3, and among its related super-pathways are Formation of tubulin folding intermediates by CCT/TriC and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and ATP binding. An important paralog of this gene is CCT6B.

UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT6A gene promoter:
         GR   AML1a   p53   CREB   IRF-2   deltaCREB   SEF-1 (1)   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCT6A promoter sequence
   Search SABiosciences Chromatin IP Primers for CCT6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

CCT6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT6A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056086:  view genomic region     (about GC identifiers)

Start:
56,119,323 bp from pter      End:
56,131,682 bp from pter
Size:
12,360 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 56,123,625-56,135,929     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227 (See protein sequence)
Recommended Name: T-complex protein 1 subunit zeta  
Size: 531 amino acids; 58024 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA58676.1; Type=Erroneous initiation; Sequence=BU540578; Type=Miscellaneous
discrepancy; Note=Several sequencing errors;
Secondary accessions: A6NCD2 Q3KP28 Q75LP4 Q96S46
Alternative splicing: 2 isoforms:  P40227-1   P40227-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT6A: NX_P40227

Explore proteomics data for CCT6A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40227

  • CCT6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCT6A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001009186.1  NP_001753.1  

    ENSEMBL proteins: 
     ENSP00000275603   ENSP00000352019   ENSP00000438488  
    Reactome Protein details: P40227
    Human Recombinant Protein Products for CCT6A: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT6A 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm TAS8034610
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    CCT6A for ontologies           About GeneDecksing



    CCT6A Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CCT6A 
    ThermoFisher Antibodies for CCT6A
    LSBio Antibodies in human, mouse, rat for CCT6A 

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    Cloud-Clone Corp. CLIAs for CCT6A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHAP: Heat Shock Proteins / Chaperonins

    5/7 InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P40227

    ProtoNet protein and cluster: P40227

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPZ_HUMAN, P40227
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPZ_HUMAN, P40227
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in
    vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT6A:
    chaperonin containing TCP1 (T complex protein 1),subunit 6A (zeta 1),cytoplasmic,widely expressed,S cerevisiae
    homolog,TF55/TCP-1 family

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    CCT6A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCT6A:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCT6A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCT6A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT6A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT6A 

    miRNA
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    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCCT6A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCT6A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of tubulin folding intermediates by CCT/TriC
    Formation of tubulin folding intermediates by CCT/TriC0.74
    Prefoldin mediated transfer of substrate to CCT/TriC0.70
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCT6A
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT6A
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT6A (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1048 Interacting proteins for CCT6A (P402272, 3 ENSP000002756034) via UniProtKB, MINT, STRING, and/or I2D (see all 1048)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT4P509912, 3, ENSP000003779584MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000377958
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000258091
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    EIF3IQ133472, 3, ENSP000003626884MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000362688
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT6A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT6A (TCPZ)

    Search CenterWatch for drugs/clinical trials and news about CCT6A / TCPZ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCT6A gene (2 alternative transcripts): 
    NM_001009186.1  NM_001762.3  

    Unigene Cluster for CCT6A:

    Chaperonin containing TCP1, subunit 6A (zeta 1)
    Hs.82916  [show with all ESTs]
    Unigene Representative Sequence: NM_001762
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275603(uc003trl.1 uc011kcu.1) ENST00000335503(uc003trm.1)
    ENST00000493855 ENST00000482776 ENST00000492618 ENST00000466572 ENST00000462133
    ENST00000494736 ENST00000466479 ENST00000540286

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate CCT6A (see all 23):
    hsa-miR-100* hsa-miR-137 hsa-miR-148b hsa-miR-25 hsa-miR-301a hsa-miR-205* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidCCT6A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT6A
    Sirion Biotech Customized lentivirus for stable overexpression of CCT6A 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT6A

    Additional mRNA sequence: 

    AB063318.1 AB209728.1 AF385084.1 AK297751.1 AK298371.1 AK313819.1 AK316230.1 AM295155.1 
    BC106941.1 BC106942.1 L27706.1 M94083.1 

    24/44 DOTS entries (see all 44):

    DT.97860745  DT.100039052  DT.86999971  DT.121122465  DT.100676262  DT.100674808  DT.121122337  DT.92465140 
    DT.100674814  DT.121122230  DT.121122218  DT.95289676  DT.121122255  DT.121122480  DT.100799093  DT.121122316 
    DT.121122357  DT.95227110  DT.99990326  DT.100807148  DT.91729560  DT.92465148  DT.92465157  DT.95227200 

    24/1112 AceView cDNA sequences (see all 1112):

    BM927374 CN479008 AI909411 AI094998 AA383147 AI141585 BU957724 BQ932570 
    BE896212 AL711080 BM800649 AI298773 CA438781 BU632216 BU197095 BE794328 
    N31527 BU171693 BC000224 BQ937002 BQ212989 BQ684935 CR605318 BM791112 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CCT6A (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:                                                                                      -                 -     -                           
    SP2:                    -     -                                                                                                               
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                        -     -                           


    ECgene alternative splicing isoforms for CCT6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGATAAGC
    CCT6A Expression
    About this image


    See CCT6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT6A

    SOURCE GeneReport for Unigene cluster: Hs.82916
        SABiosciences Expression via Pathway-Focused PCR Array including CCT6A: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT6A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT6A gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct6a1 , 5 chaperonin containing Tcp1, subunit 6a (zeta)1, 5 88.83(n)1
    96.8(a)1
      5 (68.26 cM)5
    124661  NM_009838.11  NP_033968.11 
     1297874395 
    chicken
    (Gallus gallus)
    Aves CCT6A1 chaperonin containing TCP1, subunit 6A (zeta 1) 81.54(n)
    89.98(a)
      417541  NM_001006216.1  NP_001006216.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.15192 Xenopus laevis transcribed sequence with moderate similarity more 78.13(n)    BQ731892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct6a2 chaperonin containing TCP1, subunit 6A (zeta 1) 76.27(n)   116994  BC044393.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82313
    Tcp-1zeta1
    chaperonin ATPase3
    T-cp1zeta1
    69(a)3
    63.72(n)1
    69.3(a)1
      13E143
    325181  NM_132838.21  NP_573066.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-61 , 3 Expression: embryo3
    Protein CCT-61
    66(a)3
    60.95(n)1
    68(a)1
      III(5925494-5926671)3
    1758191  NM_171135.51  NP_741153.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT6(YDR188W)4
    CCT61
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct6p1
    59.09(n)1
    58.14(a)1
      4(836421-838061)4
    8517681, 4  NP_010474.31  NP_010474.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G160701 TCP-1/cpn60 chaperonin family protein 61.85(n)
    63.12(a)
      831464  NM_121612.2  NP_197111.2 
    rice
    (Oryza sativa)
    Liliopsida Os.49902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.47(n)    AK065883.1 


    ENSEMBL Gene Tree for CCT6A (if available)
    TreeFam Gene Tree for CCT6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT6A gene
    CCT6B2  
    7 SIMAP similar genes for CCT6A using alignment to 3 protein entries:     TCPZ_HUMAN (see all proteins):
    CCT6B    CCT3    CCT2    TCP1    CCT5    CCT4
    CCT7

    CCT6A for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CCT6A
    PGOHUM00000242475 PGOHUM00000238300 PGOHUM00000233372 PGOHUM00000233383


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in CCT6A are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449218431,2
    --56121292(+) AAATAC/GAAAAA 2 -- int10--------
    rs102550491,2
    C,F--56121304(+) TAGCCA/GGGTGT 2 -- int110Minor allele frequency- G:0.41NA WA CSA EA 371
    rs1387486001,2
    --56121319(+) CTGCAC/TGCCTG 2 -- int10--------
    rs1865750121,2
    --56121522(+) TTGAAC/TATTTA 2 -- int10--------
    rs1918589101,2
    --56121682(+) CTACAA/GAAATA 2 -- int10--------
    rs1419819841,2
    C--56121701(+) GTGTGC/TGCCCT 2 -- int10--------
    rs1839457161,2
    C--56121777(+) ATTATG/TTGTTA 2 -- int10--------
    rs1176003821,2
    F--56121821(+) CTTCTA/GCTGAG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1900215311,2
    --56121826(+) ACTGAG/TCCTCA 2 -- int10--------
    rs1177342511,2
    C,F--56121833(+) CTCAAG/ACTTCC 2 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for CCT6A (56119323 - 56131682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCT6A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    esv28230CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104613    OMIM disorders: --

    8 diseases for CCT6A:    About MalaCards
    morphine dependence    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    endocarditis    cerebritis    tuberculosis    squamous cell carcinoma


    CCT6A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CCT6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT6A gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with CCT6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. (PubMed id 8034610)1, 2, 3, 9 Li W.Z....Sherman F. (1994)
    2. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. (PubMed id 1352881)1, 2, 3 Segel G.B....Sherman F. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    10. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 908 HGNC: 1620 AceView: CCT6AandSUMF2 Ensembl:ENSG00000146731 euGenes: HUgn908
    ECgene: CCT6A H-InvDB: CCT6A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCT6A gene:
    Search GeneIP for patents involving CCT6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Regulatory tfbs in CCT6A promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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