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CCT5 Gene

protein-coding   GIFtS: 69
GCID: GC05P010236

Chaperonin Containing TCP1, Subunit 5 (Epsilon)

  See CCT5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 5 (Epsilon)1 2     HEL-S-692
CCTE2 3 5     Epididymis Secretory Protein Li 692
CCT-epsilon2 3     T-Complex Protein 1 Subunit Epsilon2
TCP-1-epsilon2 3     T-Complex Protein 1, Epsilon Subunit2
KIAA00983 5     

External Ids:    HGNC: 16181   Entrez Gene: 229482   Ensembl: ENSG000001507537   OMIM: 6101505   UniProtKB: P486433   

Export aliases for CCT5 gene to outside databases

Previous GC identifers: GC05P010418 GC05P010283 GC05P010303


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT5 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In
addition, three pseudogenes of this gene have been identified. (provided by RefSeq, Jun 2010)

GeneCards Summary for CCT5 Gene:
CCT5 (chaperonin containing TCP1, subunit 5 (epsilon)) is a protein-coding gene. Diseases associated with CCT5 include neuropathy, hereditary sensory, with spastic paraplegia, and autosomal recessive sensory neuropathy with spastic paraplegia. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT5 gene promoter:
         Max1   AML1a   NF-kappaB   LCR-F1   GATA-1   E2F-1   E2F   HOXA5   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT5 promoter sequence
   Search Chromatin IP Primers for CCT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

CCT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P010236:  view genomic region     (about GC identifiers)

Start:
10,250,033 bp from pter      End:
10,266,524 bp from pter
Size:
16,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643 (See protein sequence)
Recommended Name: T-complex protein 1 subunit epsilon  
Size: 541 amino acids; 59671 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity)
Sequence caution: Sequence=BAA07894.2; Type=Erroneous initiation;
Secondary accessions: A8JZY8

Explore the universe of human proteins at neXtProt for CCT5: NX_P48643

Explore proteomics data for CCT5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys35, Lys42, Lys64, Lys150, Lys160, Lys176, Lys210, Lys232, Lys263,
                                 Lys265, Lys275, Lys284, Lys352, Lys378, Lys392, Lys439, Lys483, Lys496, Lys514 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See CCT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036205.1  
    ENSEMBL proteins: 
     ENSP00000280326   ENSP00000423318   ENSP00000426923   ENSP00000423087   ENSP00000425751  
     ENSP00000422744   ENSP00000427297   ENSP00000423052  
    Reactome Protein details: P48643

    CCT5 Human Recombinant Protein Products:

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    Novus Biologicals CCT5 Protein
    Novus Biologicals CCT5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT5

     
    Search eBioscience for Proteins for CCT5 

    CCT5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CCT5
    Cloud-Clone Corp. Antibodies for CCT5
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    LSBio Antibodies in human, mouse, rat for CCT5

    CCT5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT5
    Cloud-Clone Corp. CLIAs for CCT5
    Search eBioscience for ELISAs for CCT5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P48643

    ProtoNet protein and cluster: P48643

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643
    Similarity: Belongs to the TCP-1 chaperonin family


    Find genes that share domains with CCT5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPE_HUMAN, P48643
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for CCT5:
    chaperonin containing TCP1 (T complex protein 1),subunit 5 (epsilon),cytosolic,TF55/TCP-1 family

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0031681G-protein beta-subunit binding IPI19376773
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with CCT5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCT5:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT5:
    hsa-mir-124-3p (MIRT022974), hsa-mir-23a-3p (MIRT050415), hsa-mir-151a-5p (MIRT038196), hsa-mir-935 (MIRT036657), hsa-mir-1914-5p (MIRT035787)

    Block miRNA regulation of human, mouse, rat CCT5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CCT5:
    hsa-miR-409-5p hsa-miR-4310 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCCT5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT5
    Predesigned siRNA for gene silencing in human, mouse, rat CCT5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT5

    Clone
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    OriGene clones in human, mouse for CCT5 (see all 7)
    OriGene ORF clones in mouse, rat for CCT5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT5 (NM_012073)
    Sino Biological Human cDNA Clone for CCT5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPE_HUMAN, P48643: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CCT5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT5 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with CCT5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT5
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT5
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT5: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT5 (P486432, 3 ENSP000002803264) via UniProtKB, MINT, STRING, and/or I2D (see all 1085)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=6 STRING: ENSP00000317334
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    TP53P046372, 3, ENSP000002693054MINT-63773 MINT-8415355 I2D: score=5 STRING: ENSP00000269305
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000349960
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0009615response to virus IEP16548883
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with CCT5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT5 (TCPE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCT5 gene: 
    NM_012073.3  

    Unigene Cluster for CCT5:

    Chaperonin containing TCP1, subunit 5 (epsilon)
    Hs.1600  [show with all ESTs]
    Unigene Representative Sequence: NM_012073
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280326(uc003jeq.3 uc011cmr.2 uc011cms.2 uc011cmt.2)
    ENST00000503026 ENST00000515390 ENST00000511700 ENST00000508451 ENST00000510326
    ENST00000512975 ENST00000423695(uc011cmq.2) ENST00000503454 ENST00000515676
    ENST00000506600 ENST00000514674 ENST00000509846 ENST00000511995
    miRNA
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    Block miRNA regulation of human, mouse, rat CCT5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CCT5:
    hsa-miR-409-5p hsa-miR-4310 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCCT5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCT5
    Clone
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    OriGene clones in human, mouse for CCT5 (see all 7)
    OriGene ORF clones in mouse, rat for CCT5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT5 (NM_012073)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT5
    Primer
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    OriGene qPCR primer pairs and template standards for CCT5
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT5
      QuantiTect SYBR Green Assays in human, mouse, rat CCT5
      QuantiFast Probe-based Assays in human, mouse, rat CCT5

    Additional mRNA sequence: 

    AF275798.1 AJ012489.1 AK124354.1 AK289353.1 AK290393.1 AK293341.1 AK293437.1 AK301760.1 
    AK301985.1 AK302368.1 AK302383.1 AK303086.1 AK303147.1 AK316376.1 BC002971.1 BC006543.2 
    BC009454.1 BC035499.2 BC040027.1 D43950.2 

    Selected DOTS entries (see all 52):

    DT.100045540  DT.100637605  DT.100864008  DT.100872167  DT.100691724  DT.91892653  DT.100691732  DT.95204903 
    DT.120822030  DT.91970225  DT.100691735  DT.120821924  DT.95179368  DT.120821922  DT.97760563  DT.120821959 
    DT.91888838  DT.100691726  DT.120821908  DT.92058342  DT.91785056  DT.91896320  DT.95117642  DT.120821935 

    Selected AceView cDNA sequences (see all 1343):

    AI244396 CB305709 BQ648603 BG403251 AA721250 BU196345 BI260446 BP354297 
    CR596856 R73042 BG110105 BG035730 AA769184 AA659840 CR606787 BE312768 
    BG029063 BG286401 CR605385 BC040027 AA773179 AA311028 CR611397 CB134121 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT5 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^
    SP1:                                            -                 -                                                           -                                 
    SP2:                                            -                 -                                               -     -     -     -     -                     
    SP3:                                                              -     -     -     -     -     -                             -                                 
    SP4:                                                                                                                          -                                 
    SP5:                                            -                 -           -                                               -                                 

    ExUns: 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                      -                           
    SP5:                                                                  


    ECgene alternative splicing isoforms for CCT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAGAAAC
    CCT5 Expression
    About this image


    CCT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    CCT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1600
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT5: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCT5
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT5
    QuantiTect SYBR Green Assays in human, mouse, rat CCT5
    QuantiFast Probe-based Assays in human, mouse, rat CCT5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT5 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct51 , 5 chaperonin containing Tcp1, subunit 5 (epsilon)1, 5 87.25(n)1
    96.3(a)1
      15 (13.02 cM)5
    124651  NM_007637.21  NP_031663.11 
     315908005 
    chicken
    (Gallus gallus)
    Aves CCT51 chaperonin containing TCP1, subunit 5 (epsilon) 80.9(n)
    91.31(a)
      420930  NM_001012563.2  NP_001012581.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT56
    chaperonin containing TCP1, subunit 5 (epsilon)
    89(a)
    1 ↔ 1
    4(82221188-82249310)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct5-prov2 chaperonin containing TCP1, subunit 5 (epsilon) 79.23(n)    BC044997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kifc12 Danio rerio clone RK074A2D01 chaperonin containing TCP1, subunit 5 (epsilon) (CCT5) mRNA, complete cds less 78(n)    AY398321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cct51 , 3 protein folding chaperonin ATPase3
    T-complex Chaperonin 51
    71(a)3
    66.54(n)1
    71.16(a)1
      363081  NM_078983.31  NP_523707.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-51 , 3 TCP-1 like chaperonin3
    cct-51
    70(a)3
    63.85(n)1
    69.17(a)1
      III(4571254-4579877)3
    1755881  NM_171104.31  NP_741117.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT5(YJR064W)4
    CCT51
    Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo less4
    CCT51
    60.29(n)1
    60.59(a)1
      10(555914-557602)4
    8535271, 4  NP_012598.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G245101 AT1G24510 65.46(n)
    68.88(a)
      839066  NM_102295.5  NP_173859.1 
    rice
    (Oryza sativa)
    Liliopsida Os.104532 Oryza sativa (japonica cultivar-group) cDNA clone001-201-D07, full insert sequence less 73.38(n)    AK067114.1 


    ENSEMBL Gene Tree for CCT5 (if available)
    TreeFam Gene Tree for CCT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT5 gene
    8 SIMAP similar genes for CCT5 using alignment to 8 protein entries:     TCPE_HUMAN (see all proteins):
    CCT4    CCT2    CCT3    CCT7    TCP1    CCT8
    CCT6B    CCT6A

    Find genes that share paralogs with CCT5           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CCT5
    PGOHUM00000249949 PGOHUM00000249957 PGOHUM00000251389


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT5 (see all 558)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0306584
    Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)4--see VAR_0306582 H R mis40--------
    rs1182039861,2
    Cpathogenic110242489(+) TGAACA/GCCTGG 2 H R mis10--------
    rs1918589501,2
    --10234739(+) TTTGAC/TAGGGA 1 -- us2k10--------
    rs1493203611,2
    C--10234785(+) TTTTCA/TCAACA 1 -- us2k10--------
    rs38443051,2
    C,F,A,H--10234887(+) AAATCT/CAAAAT 1 -- us2k119Minor allele frequency- C:0.16NS EA NA WA CSA 2300
    rs1836716611,2
    --10235014(+) TCTGTC/TGCCCA 1 -- us2k10--------
    rs38521641,2
    C,F,A,H--10235054(-) agtttA/Gcagtg 1 -- us2k116Minor allele frequency- G:0.17NS EA NA WA CSA 2052
    rs25786191,2
    C,F,A,H--10235112(-) ACTGTA/GTTCCC 1 -- us2k1 tfbs328Minor allele frequency- G:0.33NS EA NA WA CSA 2777
    rs1446234571,2
    --10235134(+) TTCTTC/GAGTTT 1 -- us2k10--------
    rs1147787381,2
    C,F--10235187(+) ACTTAT/CTGAGT 1 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for CCT5 (10250033 - 10266524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33231CNV Loss17666407
    nsv461975CNV Gain19166990
    nsv830201CNV Gain17160897
    nsv881429CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCT5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT5
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610150   
    OMIM disorders: 256840  
    UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643
  • Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) [MIM:256840]: A
    disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating
    ulcerations of the upper and lower limbs. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 2 diseases for CCT5:    
    About MalaCards
    neuropathy, hereditary sensory, with spastic paraplegia    autosomal recessive sensory neuropathy with spastic paraplegia


    Find genes that share disorders with CCT5           About GenesLikeMe

    Genetic Association Database (GAD): CCT5
    Human Genome Epidemiology (HuGE) Navigator: CCT5 (3 documents)

    Export disorders for CCT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT5 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with CCT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation in the epsilon subunit of the cytosolic chaperonin- containing T-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia. (PubMed id 16399879)1, 2, 9 Bouhouche A.... Yahyaoui M. (J. Med. Genet. 2006)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Genes for hereditary sensory and autonomic neuropathies: a genotype- phenotype correlation. (PubMed id 19651702)1, 4 Rotthier A.... Timmerman V. (Brain 2009)
    4. A genome-wide scan maps a novel high myopia locus to 5p15. (PubMed id 18421076)1, 4 Lam C.Y....Lam D.S. (amp 2008)
    5. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (Cell. Microbiol. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    9. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22948 HGNC: 1618 AceView: CCT5 Ensembl:ENSG00000150753 euGenes: HUgn22948
    ECgene: CCT5 H-InvDB: CCT5

    (According to HUGE)
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    HUGE: KIAA0098

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCT5 gene:
    Search GeneIP for patents involving CCT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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