CCT5 Gene
protein-coding GIFtS: 65
GCID: GC05P010236
|
|
chaperonin containing TCP1, subunit 5 (epsilon)
| |
Aliases
for CCT5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chaperonin Containing TCP1, Subunit 5 (Epsilon)1 2 | | TCP-1-Epsilon1 | | KIAA00981 3 5 | | T-Complex Protein 1 Subunit Epsilon2 | | CCTE2 3 5 | | T-Complex Protein 1, Epsilon Subunit2 | | CCT-Epsilon1 | | |
Export aliases for CCT5 gene to outside databasesPrevious GC identifers: GC05P010418 GC05P010283 GC05P010303 |
Summaries
for CCT5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCT5:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, eachcontaining eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded inan ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptionalsplice variants of this gene have been observed but have not been thoroughly characterized. In addition, threepseudogenes of this gene have been identified. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex mayplay a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.Known to play a role, in vitro, in the folding of actin and tubulin
Gene Wiki entry for CCT5
|
Genomic Views
for CCT5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCT5 gene promoter:
Max1 AML1a NF-kappaB LCR-F1 GATA-1 E2F-1 E2F HOXA5 NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCT5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2CCT5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P010236: view genomic region
(about GC identifiers)
Start:
|
10,250,033 bp from pter |
End:
|
10,266,524 bp from pter |
Size:
|
16,492 bases |
Orientation:
|
plus strand |
|
Proteins
for CCT5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643 (See
protein sequence)Recommended Name: T-complex protein 1 subunit epsilon Size: 541 amino acids; 59671 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome
Sequence caution: Sequence=BAA07894.2; Type=Erroneous initiation;
Secondary accessions: A8JZY8Explore the universe of human proteins at neXtProt for CCT5: NX_P48643
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48643
CCT5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036205.1
ENSEMBL proteins: ENSP00000280326 ENSP00000423318 ENSP00000426923 ENSP00000423087 ENSP00000425751 ENSP00000422744 ENSP00000427297 ENSP00000423052 Reactome Protein details: P48643
Human Recombinant Protein Products for CCT5:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CCT5 for ontologies About GeneDecksing
CCT5 Antibody Products:
Assay Products for CCT5: |
Protein
Domains /
Families
for CCT5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCT5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48643ProtoNet protein and cluster: P48643 2 Blocks protein families: IPB001844 Chaperonin Cpn60 IPB002194 Chaperonin TCP-1
UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643Similarity: Belongs to the TCP-1 chaperonin family |
Function
for CCT5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TCPE_HUMAN, P48643Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex mayplay a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.Known to play a role, in vitro, in the folding of actin and tubulinInduction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level) Genatlas biochemistry entry for CCT5:chaperonin containing TCP1 (T complex protein 1),subunit 5 (epsilon),cytosolic,TF55/TCP-1 family
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CCT5 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CCT5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCT5 (NM_012073) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCT5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT5 |
|
Pathways & Interactions
for CCT5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of tubulin folding intermediates by CCT/TriC | | | 2 | Chaperonin-mediated protein folding | | | 3 | Cell cycle Role of APC in cell cycle regulation | | | 4 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CCT5
1  GeneGo (Thomson Reuters) Pathway for CCT5
5/8 
Reactome Pathways for CCT5 (see all 8)
CCT5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/967 Interacting proteins for CCT5 (P486432, 3 ENSP000002803264) via UniProtKB, MINT, STRING, and/or I2D (see all 967)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TCP1 | P179872, 3, ENSP000003173344 | MINT-7945693 MINT-8415355 MINT-7947479 I2D:
score=6 STRING: ENSP00000317334 | | CCT3 | P493682, 3, ENSP000003572444 | MINT-7945693 MINT-8415355 MINT-7947479 I2D:
score=2 STRING: ENSP00000357244 | | TP53 | P046372, 3, ENSP000002693054 | MINT-63773 MINT-8415355 I2D:
score=5 STRING: ENSP00000269305 | | ACTB | P607092, 3, ENSP000003499604 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000349960 | | HNRNPH1 | P319432, 3, ENSP000003491684 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000349168 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CCT5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCT5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCT5
Search CenterWatch for drugs/clinical trials and news about CCT5 / TCPE
|
Transcripts
for CCT5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCT5 gene: NM_012073.3 Unigene Cluster for CCT5: Chaperonin containing TCP1, subunit 5 (epsilon) Hs.1600 [show with all ESTs]Unigene Representative Sequence: NM_01207314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000280326(uc003jeq.3 uc011cmr.2 uc011cms.2 uc011cmt.2)
ENST00000503026 ENST00000515390 ENST00000511700 ENST00000508451 ENST00000510326
ENST00000512975 ENST00000423695(uc011cmq.2) ENST00000503454 ENST00000515676
ENST00000506600 ENST00000514674 ENST00000509846 ENST00000511995
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCT5 (NM_012073) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCT5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT5 |
Additional cDNA sequence: AF275798.1 AJ012489.1 AK124354.1 AK289353.1 AK290393.1 AK293341.1 AK293437.1 AK301760.1 AK301985.1 AK302368.1 AK302383.1 AK303086.1 AK303147.1 AK316376.1 BC002971.1 BC006543.2 BC009454.1 BC035499.2 BC040027.1 D43950.2 24/52 DOTS entries (see all 52): DT.100045540 DT.100637605 DT.100864008 DT.100872167 DT.100691724 DT.91892653 DT.100691732 DT.95204903 DT.120822030 DT.91970225 DT.100691735 DT.120821924 DT.95179368 DT.120821922 DT.97760563 DT.120821959 DT.91888838 DT.100691726 DT.120821908 DT.92058342 DT.91785056 DT.91896320 DT.95117642 DT.120821935 24/1343 AceView cDNA sequences (see all 1343): BU196345 AA659840 CR599726 BI087447 BM928602 CR594923 AW732002 CR616179 BE784327 AA426153 BM562376 BE295495 BQ937432 D43950 BG740874 BM551312 BE271627 BU527310 AA126599 AA737443 AA258262 AA298893 BX116069 CR617351
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CCT5 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
| ExUns: | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCT5
|
Expression
for CCT5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATAGAAAC
About this image
See CCT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCT5
SOURCE GeneReport for Unigene cluster: Hs.1600
SABiosciences Expression via Pathway-Focused PCR Arrays including CCT5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT5 |
Orthologs
for CCT5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCT5 gene from 10/41 species (see all 41) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cct51 , 5 |
chaperonin containing Tcp1, subunit 5 (epsilon)1, 5 |
87.25(n)1
96.3(a)1 |
|
15 (13.02 cM)5
124651 NM_007637.21 NP_031663.11
315908005 |
chicken
(Gallus gallus) |
Aves |
CCT51 |
chaperonin containing TCP1, subunit 5 (epsilon) |
80.9(n)
91.31(a) |
|
420930 NM_001012563.1 NP_001012581.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CCT56 |
-- |
88(a) |
1 ↔ 1 |
4(82240740-82249292) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cct5-prov2 |
chaperonin containing TCP1, subunit 5 (epsilon) |
79.23(n) |
|
BC044997.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
kifc12 |
Danio rerio clone RK074A2D01 chaperonin containing more |
78(n) |
|
AY398321.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cct51 , 3 |
protein folding chaperonin ATPase3
T-complex Chaperonin 51 |
71(a)3
66.54(n)1
71.16(a)1 |
|
363081 NM_078983.31 NP_523707.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cct-51 , 3 |
TCP-1 like chaperonin3
Protein CCT-51 |
70(a)3
63.8(n)1
68.91(a)1 |
|
III(4571254-4579877)3
1755881 NM_171104.21 NP_741117.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CCT5(YJR064W)4
CCT51 |
Subunit of the cytosolic chaperonin Cct ring complex, more4
Cct5p1 |
60.22(n)1
60.59(a)1 |
|
10(555914-557602)4
8535271, 4 NP_012598.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G245101 |
T-complex protein 1 subunit epsilon |
65.46(n)
68.88(a) |
|
839066 NM_102295.5 NP_173859.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.104532 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
73.38(n) |
|
AK067114.1 |
ENSEMBL Gene Tree for CCT5 (if available)
TreeFam Gene Tree for CCT5 (if available) |
Paralogs
for CCT5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCT5 gene
8 SIMAP similar genes for CCT5 using alignment to 8 protein entries: TCPE_HUMAN (see all proteins):CCT4 CCT2 CCT3 TCP1 CCT8 CCT7
CCT6A CCT6B
CCT5 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CCT5
PGOHUM00000249949 PGOHUM00000249957 PGOHUM00000251389
|
Genomic Variants
for CCT5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCT5 (10250033 - 10266524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCT5
1 CNV: 7462
Human Gene Mutation Database (HGMD): CCT5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT5 |
|
Disorders
/ Diseases
for CCT5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCT5 for disorders About GeneDecksing
OMIM gene information: 610150
OMIM disorders: 256840
UniProtKB/Swiss-Prot: TCPE_HUMAN, P48643
Defects in CCT5 are the cause of hereditary sensory neuropathy autosomal recessive with spastic paraplegia(HSNSP) [MIM:256840]. The disease is characterized by spastic paraplegia and progressive distal sensory neuropathyleading to mutilating ulcerations of the upper and lower limbs
20/23  diseases for CCT5 (see all 23): About MalaCardsneuropathy, hereditary sensory, with spastic paraplegia cerebral cavernous malformations cavernous malformation spastic paraplegia
cerebral cavernous malformations 3 sensory peripheral neuropathy hereditary sensory neuropathy paraplegia
autonomic neuropathy anhidrosis anorexia nervosa spasticity
neuropathy peripheral neuropathy down syndrome myopia
cerebritis rhabdomyosarcoma hepatocellular carcinoma alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: CCT5 (3 documents)
Export disorders for CCT5 gene to outside databases
|
Publications
for CCT5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCT5 gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with CCT5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutation in the epsilon subunit of the cytosolic chaperonin- containing T-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia. (PubMed id 16399879)1, 2, 9 Bouhouche A.... Yahyaoui M. (2006)
- Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
- A novel function of the human chaperonin CCT epsilon s ubunit in yeast. (PubMed id 22232265)1 Nikawa J. and Kimura M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
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External Searches for CCT5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CCT5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CCT5 gene
(According to HUGE)
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Specialized Databases showing CCT5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CCT5 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CCT5 gene:
Search GeneIP for patents involving CCT5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CCT5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for CCT5 | | OriGene shRNA RFP for CCT5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCT5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCT5 | | | OriGene Protein Over-expression Lysate for CCT5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCT5 | | OriGene 3'-UTR Clone for CCT5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCT5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCT5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCT5 | | OriGene Custom Protein Services for CCT5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCT5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT5 |
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| | | | Search Tocris compounds for CCT5 |
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 | | | CCT5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT5 |
|  |  |  |  | | | | ThermoFisher Antibody for CCT5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT5 |
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