Aliases for CCT5 Gene
Aliases for CCT5 Gene
External Ids for CCT5 Gene
- HGNC: 1618
- Entrez Gene: 22948
- Ensembl: ENSG00000150753
- OMIM: 610150
- UniProtKB: P48643
Previous GeneCards Identifiers for CCT5 Gene
- GC05P010418
- GC05P010283
- GC05P010303
Summaries for CCT5 Gene
-
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
GeneCards Summary for CCT5 Gene
CCT5 (Chaperonin Containing TCP1 Subunit 5) is a Protein Coding gene. Diseases associated with CCT5 include Neuropathy, Hereditary Sensory, With Spastic Paraplegia and Autosomal Recessive Sensory Neuropathy With Spastic Paraplegia. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and G-protein beta-subunit binding.
UniProtKB/Swiss-Prot for CCT5 Gene
-
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT5 Gene
Genomics for CCT5 Gene
Regulatory Elements for CCT5 Gene
Enhancers for CCT5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCT5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCT5 gene promoter:
Regulatory Element Products
Genomic Location for CCT5 Gene
- Chromosome:
- 5
- Start:
- 10,249,921 bp from pter
- End:
- 10,266,412 bp from pter
- Size:
- 16,492 bases
- Orientation:
- Plus strand
Genomic View for CCT5 Gene
Genes around CCT5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.2 by Ensembl
- 5p15.2 by Entrez Gene
- 5p15.2 by HGNC
CCT5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCT5 Gene
Proteins for CCT5 Gene
-
Protein details for CCT5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48643-TCPE_HUMAN
- Recommended name:
- T-complex protein 1 subunit epsilon
- Protein Accession:
- P48643
- A8JZY8
- A8K2X8
- B4DYD8
Protein attributes for CCT5 Gene
- Size:
- 541 amino acids
- Molecular mass:
- 59671 Da
- Quaternary structure:
-
- Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA07894.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CCT5 Gene
Post-translational modifications for CCT5 Gene
- Ubiquitination at posLast=3535, Lys42, Lys64, Lys150, Lys160, posLast=176176, posLast=210210, posLast=232232, posLast=263263, Lys265, posLast=275275, Lys284, posLast=352352, Lys378, Lys392, Lys439, posLast=483483, Lys496, posLast=514514, and posLast=535535
- Modification sites at PhosphoSitePlus
Other Protein References for CCT5 Gene
Antibody Products
- Novus Biologicals Antibodies for CCT5
- Invitrogen Antibodies for CCT5
- antibodies-online Antibodies for CCT5: See all 60
- GeneTex CCT5 antibody for CCT5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCT5
Protein Products
-
OriGene Purified Proteins for CCT5
- Search Origene for MassSpec and Protein Over-expression Lysates for CCT5
- Origene Custom Protein Services for CCT5
- antibodies-online Proteins for CCT5: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CCT5
Assay Products
- antibodies-online Kits for CCT5: See all 1
No data available for DME Specific Peptides for CCT5 Gene
Domains & Families for CCT5 Gene
Gene Families for CCT5 Gene
- HGNC:
Protein Domains for CCT5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCT5 Gene
Graphical View of Domain Structure for InterPro Entry
P48643- Family:
-
- Belongs to the TCP-1 chaperonin family.
Function for CCT5 Gene
Molecular function for CCT5 Gene
- GENATLAS Biochemistry:
- chaperonin containing TCP1 (T complex protein 1),subunit 5 (epsilon),cytosolic,TF55/TCP-1 family
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3-UTR binding | IDA | 16213212 |
| GO:0005515 | protein binding | IPI | 14532270 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0031681 | G-protein beta-subunit binding | IPI | 19376773 |
| GO:0044183 | protein binding involved in protein folding | IBA | -- |
Phenotypes for CCT5 Gene
- GenomeRNAi human phenotypes for CCT5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCT5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCT5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT5 gene
- Search ViGene Biosciences for CCT5
CRISPR Products
-
OriGene CRISPR knockouts for CCT5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT5
- GenScript: Design CRISPR guide RNA sequences for CCT5
miRNA for CCT5 Gene
- miRTarBase miRNAs that target CCT5
-
- hsa-mir-124-3p (MIRT022974)
- hsa-mir-1914-5p (MIRT035787)
- hsa-mir-935 (MIRT036657)
- hsa-mir-151a-5p (MIRT038196)
- hsa-mir-23a-3p (MIRT050415)
- hsa-mir-1231 (MIRT538612)
- hsa-mir-1299 (MIRT538613)
- hsa-mir-4795-3p (MIRT538614)
- hsa-mir-6128 (MIRT538615)
- hsa-mir-875-3p (MIRT538616)
- hsa-mir-6733-3p (MIRT538617)
- hsa-mir-139-5p (MIRT538618)
miRNA Products
- Search ViGene Biosciences for CCT5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCT5
- Browse OriGene Inhibitory RNA Products For CCT5
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT5 gene
Clone Products
- Sino Biological Human cDNA Clone for CCT5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCT5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCT5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCT5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT5 Gene
Localization for CCT5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCT5 Gene
- Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002199 | zona pellucida receptor complex | IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 20080638 |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for CCT5 Gene
Pathways by source for CCT5 Gene
1 GeneGo (Thomson Reuters) pathway for CCT5 Gene
Interacting Proteins for CCT5 Gene
Selected Interacting proteins:
P48643-TCPE_HUMAN
ENSP00000280326
for CCT5 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | -- |
| GO:0006458 | de novo protein folding | IBA | -- |
| GO:0007339 | binding of sperm to zona pellucida | IEA | -- |
| GO:0009615 | response to virus | IEP | 16548883 |
| GO:0032212 | positive regulation of telomere maintenance via telomerase | IMP | 25467444 |
No data available for SIGNOR curated interactions for CCT5 Gene
Transcripts for CCT5 Gene
mRNA/cDNA for CCT5 Gene
- (5) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (1343) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCT5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCT5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCT5
- GenScript: Design CRISPR guide RNA sequences for CCT5
miRNA Products
- Search ViGene Biosciences for CCT5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCT5
- Browse OriGene Inhibitory RNA Products For CCT5
-
ViGene Biosciences ready-to-package AAV shRNAs for CCT5 gene
Clone Products
- Sino Biological Human cDNA Clone for CCT5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCT5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - |
| ExUns: | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||
| SP14: |
Expression for CCT5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCT5 Gene:
CCT5SOURCE GeneReport for Unigene cluster for CCT5 Gene:
Hs.1600Evidence on tissue expression from TISSUES for CCT5 Gene
- Nervous system(5)
- Lung(4.9)
- Liver(4.8)
- Blood(4.7)
- Bone marrow(4.3)
- Intestine(4.1)
- Skin(4)
- Eye(3.7)
- Kidney(3.2)
- Pancreas(3.2)
- Stomach(2.7)
- Heart(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT5 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- nervous
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- head
Thorax:
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for CCT5
-
OriGene qPCR primer pairs for CCT5
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT5 Gene
Orthologs for CCT5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCT5 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCT5 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCT5 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCT5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCT5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cct5 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cct5 34 |
|
||
| chicken (Gallus gallus) |
Aves | CCT5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CCT5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cct5 34 |
|
||
| MGC76252 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cct5-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cct5 34 35 |
|
||
| kifc1 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3460 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cct5 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008249 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cct-5 36 34 35 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR418W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B13882g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CCT5 34 35 37 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G24510 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.2634 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10411 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0562600 34 |
|
||
| Os.10453 34 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4118 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.19112 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.5476 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3810 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03980 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cct5 34 |
|
- Species where no ortholog for CCT5 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for CCT5 Gene
(8) SIMAP similar genes for CCT5 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for CCT5 Gene
No data available for Paralogs for CCT5 Gene
Variants for CCT5 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs118203986 | Pathogenic, Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) [MIM:256840] | 10,256,063(+) | TGAAC(A/G)CCTGG | reference, missense | |
| rs114441137 | Likely benign | 10,265,649(+) | GATAC(A/C)CTTTC | utr-variant-3-prime | |
| rs11557649 | Likely benign | 10,258,400(+) | GATGC(A/G)AAGAT | reference, synonymous-codon | |
| rs11557652 | Likely benign | 10,256,060(+) | TATTG(A/G/T)ACACC | reference, missense | |
| rs11956986 | Likely benign | 10,266,160(+) | TGAGT(C/G)TAGCC | utr-variant-3-prime |
Residual Variation Intolerance Score:
16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.11;
51.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCT5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT5 Gene
Disorders for CCT5 Gene
(7) MalaCards diseases for CCT5 Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuropathy, hereditary sensory, with spastic paraplegia |
|
|
| autosomal recessive sensory neuropathy with spastic paraplegia |
|
|
| epididymo-orchitis |
|
|
| neuropathy |
|
|
| hereditary sensory neuropathy |
|
|
Search CCT5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TCPE_HUMAN- Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) [MIM:256840]: A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs. {ECO:0000269 PubMed:16399879}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CCT5
No data available for Genatlas for CCT5 Gene
Publications for CCT5 Gene
- Mutation in the epsilon subunit of the cytosolic chaperonin- containing T-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia. (PMID: 16399879) Bouhouche A. … Yahyaoui M. (J. Med. Genet. 2006) 3 4 22 64
- BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
- Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
- Genes for hereditary sensory and autonomic neuropathies: a genotype- phenotype correlation. (PMID: 19651702) Rotthier A. … Timmerman V. (Brain 2009) 3 46 64
- A genome-wide scan maps a novel high myopia locus to 5p15. (PMID: 18421076) Lam C.Y. … Lam D.S. (Invest. Ophthalmol. Vis. Sci. 2008) 3 46 64
Products for CCT5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCT5
- Search Origene for MassSpec and Protein Over-expression Lysates for CCT5
- Origene Custom Protein Services for CCT5
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCT5
- Browse OriGene Inhibitory RNA Products For CCT5
- OriGene qPCR primer pairs and template standards for CCT5
- OriGene qPCR primer pairs for CCT5
- OriGene CRISPR knockouts for CCT5
- OriGene ORF clones in human for CCT5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCT5
- GenScript: Next-day shipping cDNA ORF clone for CCT5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CCT5
- GenScript Custom Assay Services for CCT5
- GenScript Custom overexpressing Cell Line Services for CCT5
- GenScript: Design CRISPR guide RNA sequences for CCT5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCT5
- Sino Biological Human cDNA Clone for CCT5
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCT5
- Novus Biologicals proteins and lysates for CCT5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CCT5: See all 60
- antibodies-online Kits for CCT5: See all 1
- antibodies-online Proteins for CCT5: See all 4
- Search antibodies-online for peptides
- GeneTex CCT5 antibody for CCT5
- Search GeneTex for Proteins for CCT5
- ViGene Biosciences adenoviral particle packaged cDNA for CCT5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCT5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCT5 gene
- Search ViGene Biosciences for CCT5
- Santa Cruz Biotechnology (SCBT) Antibodies for CCT5
- Search Santa Cruz Biotechnology (SCBT) for CCT5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCT5
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCT5
- VectorBuilder custom plasmid, inducible vectors for CCT5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCT5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCT5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer