Aliases for CCT4 Gene
External Ids for CCT4 Gene
Previous GeneCards Identifiers for CCT4 Gene
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CCT4 Gene
CCT4 (Chaperonin Containing TCP1 Subunit 4) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.
UniProtKB/Swiss-Prot for CCT4 Gene
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.