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Aliases for CCT4 Gene

Aliases for CCT4 Gene

  • Chaperonin Containing TCP1, Subunit 4 (Delta) 2 3
  • Cctd 3 4 6
  • SRB 3 4 6
  • Stimulator Of TAR RNA-Binding 3 4
  • TCP-1-Delta 3 4
  • CCT-DELTA 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Delta Subunit 3
  • T-Complex Protein 1 Subunit Delta 3

External Ids for CCT4 Gene

Summaries for CCT4 Gene

Entrez Gene Summary for CCT4 Gene

  • The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCT4 Gene

CCT4 (Chaperonin Containing TCP1, Subunit 4 (Delta)) is a Protein Coding gene. Diseases associated with CCT4 include sensory peripheral neuropathy and hereditary sensory neuropathy. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for CCT4 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT4 Gene

Genomics for CCT4 Gene

Genomic Location for CCT4 Gene

Start:
61,868,089 bp from pter
End:
61,888,804 bp from pter
Size:
20,716 bases
Orientation:
Minus strand

Genomic View for CCT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT4 Gene

Regulatory Elements for CCT4 Gene

Proteins for CCT4 Gene

  • Protein details for CCT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50991-TCPD_HUMAN
    Recommended name:
    T-complex protein 1 subunit delta
    Protein Accession:
    P50991
    Secondary Accessions:
    • B2R6I3
    • B7Z8B1
    • F5H5W3
    • O14870
    • Q53QP9
    • Q96C51

    Protein attributes for CCT4 Gene

    Size:
    539 amino acids
    Molecular mass:
    57924 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).

    Alternative splice isoforms for CCT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT4 Gene

Proteomics data for CCT4 Gene at MOPED

Post-translational modifications for CCT4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys42, Lys55, Lys65, Lys79, Lys126, Lys139, Lys213, Lys288, Lys319, Lys384, Lys489, and Lys531

Other Protein References for CCT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT4 Gene

Domains for CCT4 Gene

Gene Families for CCT4 Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

UniProtKB/Swiss-Prot:

TCPD_HUMAN
Family:
  • Belongs to the TCP-1 chaperonin family.:
    • P50991
genes like me logo Genes that share domains with CCT4: view

Function for CCT4 Gene

Molecular function for CCT4 Gene

GENATLAS Biochemistry: chaperonin containing TCP1 (T complex protein 1) subunit 4 (delta),cytosolic,TF55/TCP-1 family,required for the maturation of cyclin E
UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24846140
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT4: view
genes like me logo Genes that share phenotypes with CCT4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT4 Gene

Localization for CCT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT4 Gene

Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT4 Gene COMPARTMENTS Subcellular localization image for CCT4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 20080638
genes like me logo Genes that share ontologies with CCT4: view

Pathways for CCT4 Gene

genes like me logo Genes that share pathways with CCT4: view

Gene Ontology (GO) - Biological Process for CCT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT4: view

Transcripts for CCT4 Gene

Unigene Clusters for CCT4 Gene

Chaperonin containing TCP1, subunit 4 (delta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for CCT4 Gene

GeneLoc Exon Structure for
CCT4
ECgene alternative splicing isoforms for
CCT4

Expression for CCT4 Gene

mRNA expression in normal human tissues for CCT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT4 Gene

SOURCE GeneReport for Unigene cluster for CCT4 Gene Hs.421509

genes like me logo Genes that share expressions with CCT4: view

Orthologs for CCT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT4 36
  • 99.81 (n)
  • 100 (a)
CCT4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT4 36
  • 93.26 (n)
  • 96.85 (a)
CCT4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT4 36
  • 92.95 (n)
  • 98.14 (a)
CCT4 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct4 36
  • 90.72 (n)
  • 96.66 (a)
Cct4 16
Cct4 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT4 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cct4 36
  • 89.86 (n)
  • 96.85 (a)
chicken
(Gallus gallus)
Aves CCT4 36
  • 79.54 (n)
  • 91.23 (a)
CCT4 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT4 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398959 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cct4 36
  • 78.91 (n)
  • 90.17 (a)
Str.2717 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1747 36
zebrafish
(Danio rerio)
Actinopterygii cct4 36
  • 74.61 (n)
  • 88.76 (a)
cct4 37
  • 87 (a)
OneToOne
zgc65789 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009505 36
  • 63.75 (n)
  • 71.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5525 36
  • 63.75 (n)
  • 70.43 (a)
CG5525 37
  • 68 (a)
OneToOne
CG5525 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-4 36
  • 61.53 (n)
  • 65.11 (a)
cct-4 37
  • 62 (a)
OneToOne
cct-4 38
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR083W 36
  • 57.13 (n)
  • 59.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT4 36
  • 60.61 (n)
  • 60.74 (a)
CCT4 37
  • 59 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05005g 36
  • 59.86 (n)
  • 59.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10395 36
soybean
(Glycine max)
eudicotyledons Gma.5713 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18190 36
  • 62.65 (n)
  • 66.6 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2601 36
corn
(Zea mays)
Liliopsida Zm.6601 36
rice
(Oryza sativa)
Liliopsida Os.9114 36
Os02g0332200 36
  • 59.22 (n)
  • 63.3 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1648 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02839 36
  • 58.12 (n)
  • 63.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct4 36
  • 62.46 (n)
  • 66.41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12186 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.45 37
  • 69 (a)
OneToOne
Species with no ortholog for CCT4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT4 Gene

ENSEMBL:
Gene Tree for CCT4 (if available)
TreeFam:
Gene Tree for CCT4 (if available)

Paralogs for CCT4 Gene

Selected SIMAP similar genes for CCT4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT4 Gene

genes like me logo Genes that share paralogs with CCT4: view

No data available for Paralogs for CCT4 Gene

Variants for CCT4 Gene

Sequence variations from dbSNP and Humsavar for CCT4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4795 -- 61,877,401(-) GTTAA(G/T)AAGCT reference, missense
rs1534646 -- 61,871,637(-) ATATC(A/G)CTTTT intron-variant
rs1802065 -- 61,876,120(-) ATGTC(C/T)TTCTC reference, missense
rs1802066 -- 61,868,455(-) AAAAA(A/C)TAATA utr-variant-3-prime
rs1802068 -- 61,872,160(-) GGCCT(G/T)AATCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCT4 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv874229 CNV Gain 21882294
esv34000 CNV Loss 18971310
nsv458074 CNV Gain 19166990
nsv470467 CNV Gain 18288195
esv2657259 CNV Deletion 23128226
esv2720131 CNV Deletion 23290073

Relevant External Links for CCT4 Gene

HapMap Linkage Disequilibrium report
CCT4

Disorders for CCT4 Gene

(1) University of Copenhagen DISEASES for CCT4 Gene

(1) Novoseek inferred disease relationships for CCT4 Gene

Disease -log(P) Hits PubMed IDs
sensory neuropathy 70.1 1
genes like me logo Genes that share disorders with CCT4: view

No data available for UniProtKB/Swiss-Prot for CCT4 Gene

Publications for CCT4 Gene

  1. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F. … Gaynor R.B. (J. Biol. Chem. 1996) 3 4 23
  2. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4
  4. Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11. (PMID: 8661059) Nabetani A. … Mukai T. (Genomics 1996) 3 23
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for CCT4 Gene

Sources for CCT4 Gene

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