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Aliases for CCT4 Gene

Aliases for CCT4 Gene

  • Chaperonin Containing TCP1 Subunit 4 2 3
  • Chaperonin Containing TCP1, Subunit 4 (Delta) 2 3 5
  • Stimulator Of TAR RNA-Binding 3 4
  • TCP-1-Delta 3 4
  • CCT-DELTA 3 4
  • Cctd 3 4
  • SRB 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Delta Subunit 3

External Ids for CCT4 Gene

Previous GeneCards Identifiers for CCT4 Gene

  • GC02M062223
  • GC02M062281
  • GC02M062052
  • GC02M062070
  • GC02M062069
  • GC02M062006
  • GC02M062095

Summaries for CCT4 Gene

Entrez Gene Summary for CCT4 Gene

  • The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCT4 Gene

CCT4 (Chaperonin Containing TCP1 Subunit 4) is a Protein Coding gene. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and G-protein activation. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT4 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT4 Gene

Genomics for CCT4 Gene

Regulatory Elements for CCT4 Gene

Enhancers for CCT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCT4 on UCSC Golden Path with GeneCards custom track

Promoters for CCT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT4 Gene

61,868,089 bp from pter
61,888,804 bp from pter
20,716 bases
Minus strand

Genomic View for CCT4 Gene

Genes around CCT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT4 Gene

Proteins for CCT4 Gene

  • Protein details for CCT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 1 subunit delta
    Protein Accession:
    Secondary Accessions:
    • B2R6I3
    • B7Z8B1
    • F5H5W3
    • O14870
    • Q53QP9
    • Q96C51

    Protein attributes for CCT4 Gene

    539 amino acids
    Molecular mass:
    57924 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).

    Alternative splice isoforms for CCT4 Gene


neXtProt entry for CCT4 Gene

Proteomics data for CCT4 Gene at MOPED

Post-translational modifications for CCT4 Gene

  • Ubiquitination at Lys 42, Lys 55, Lys 65, Lys 79, Lys 126, Lys 139, Lys 213, Lys 489, and Lys 531
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT4 Gene

Domains & Families for CCT4 Gene

Gene Families for CCT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP-1 chaperonin family.
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT4: view

Function for CCT4 Gene

Molecular function for CCT4 Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1) subunit 4 (delta),cytosolic,TF55/TCP-1 family,required for the maturation of cyclin E
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with CCT4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT4 Gene

Localization for CCT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT4 Gene

Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:17081065}.

Subcellular locations from

Jensen Localization Image for CCT4 Gene COMPARTMENTS Subcellular localization image for CCT4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 20080638
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CCT4: view

Pathways & Interactions for CCT4 Gene

genes like me logo Genes that share pathways with CCT4: view

Gene Ontology (GO) - Biological Process for CCT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0050821 protein stabilization IMP 25467444
GO:0090666 scaRNA localization to Cajal body IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT4: view

No data available for SIGNOR curated interactions for CCT4 Gene

Drugs & Compounds for CCT4 Gene

No Compound Related Data Available

Transcripts for CCT4 Gene

Unigene Clusters for CCT4 Gene

Chaperonin containing TCP1, subunit 4 (delta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - -

Relevant External Links for CCT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCT4 Gene

mRNA expression in normal human tissues for CCT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT4 Gene

SOURCE GeneReport for Unigene cluster for CCT4 Gene Hs.421509

genes like me logo Genes that share expression patterns with CCT4: view

Protein tissue co-expression partners for CCT4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT4 Gene

Orthologs for CCT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCT4 35
  • 93.26 (n)
  • 96.85 (a)
CCT4 36
  • 97 (a)
(Canis familiaris)
Mammalia CCT4 35
  • 92.95 (n)
  • 98.14 (a)
CCT4 36
  • 98 (a)
(Mus musculus)
Mammalia Cct4 35
  • 90.72 (n)
  • 96.66 (a)
Cct4 16
Cct4 36
  • 97 (a)
(Pan troglodytes)
Mammalia CCT4 35
  • 99.81 (n)
  • 100 (a)
CCT4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cct4 35
  • 89.86 (n)
  • 96.85 (a)
(Monodelphis domestica)
Mammalia CCT4 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 100 (a)
-- 36
  • 95 (a)
(Gallus gallus)
Aves CCT4 35
  • 79.54 (n)
  • 91.23 (a)
CCT4 36
  • 92 (a)
(Anolis carolinensis)
Reptilia CCT4 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cct4 35
  • 78.91 (n)
  • 90.17 (a)
Str.2717 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398959 35
(Danio rerio)
Actinopterygii cct4 35
  • 74.61 (n)
  • 88.76 (a)
zgc65789 35
cct4 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1747 35
fruit fly
(Drosophila melanogaster)
Insecta CG5525 37
  • 70 (a)
CG5525 35
  • 63.75 (n)
  • 70.43 (a)
CG5525 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009505 35
  • 63.75 (n)
  • 71.6 (a)
(Caenorhabditis elegans)
Secernentea cct-4 37
  • 64 (a)
cct-4 35
  • 61.53 (n)
  • 65.11 (a)
cct-4 36
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR083W 35
  • 57.13 (n)
  • 59.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05005g 35
  • 59.86 (n)
  • 59.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT4 35
  • 60.61 (n)
  • 60.74 (a)
CCT4 36
  • 59 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18190 35
  • 62.65 (n)
  • 66.6 (a)
(Glycine max)
eudicotyledons Gma.5713 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10395 35
(Hordeum vulgare)
Liliopsida Hv.2601 35
(Oryza sativa)
Liliopsida Os.9114 35
Os02g0332200 35
  • 59.22 (n)
  • 63.3 (a)
(Triticum aestivum)
Liliopsida Ta.1648 35
(Zea mays)
Liliopsida Zm.6601 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12186 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02839 35
  • 58.12 (n)
  • 63.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct4 35
  • 62.46 (n)
  • 66.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.45 36
  • 69 (a)
Species with no ortholog for CCT4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT4 Gene

Gene Tree for CCT4 (if available)
Gene Tree for CCT4 (if available)

Paralogs for CCT4 Gene

(8) SIMAP similar genes for CCT4 Gene using alignment to 3 proteins: Pseudogenes for CCT4 Gene

genes like me logo Genes that share paralogs with CCT4: view

No data available for Paralogs for CCT4 Gene

Variants for CCT4 Gene

Sequence variations from dbSNP and Humsavar for CCT4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2272428 - 61,880,331(+) AGCAA(C/T)GATGA reference, missense
rs1802065 -- 61,876,120(-) ATGTC(C/T)TTCTC reference, missense
rs1802066 -- 61,868,455(-) AAAAA(A/C)TAATA utr-variant-3-prime
rs1802068 -- 61,872,160(-) GGCCT(G/T)AATCC reference, synonymous-codon
rs1802069 -- 61,872,269(-) CCTAC(G/T)ATTAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCT4 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv874229 CNV Gain 21882294
esv34000 CNV Loss 18971310
nsv458074 CNV Gain 19166990
nsv470467 CNV Gain 18288195
esv2657259 CNV Deletion 23128226
esv2720131 CNV Deletion 23290073

Variation tolerance for CCT4 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCT4 Gene

Disorders for CCT4 Gene

Relevant External Links for CCT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCT4 Gene

Publications for CCT4 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PMID: 8626763) Wu-Baer F. … Gaynor R.B. (J. Biol. Chem. 1996) 3 23
  3. Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11. (PMID: 8661059) Nabetani A. … Mukai T. (Genomics 1996) 3 23
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for CCT4 Gene

Sources for CCT4 Gene