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CCT4 Gene

protein-coding   GIFtS: 65
GCID: GC02M062095

Chaperonin Containing TCP1, Subunit 4 (Delta)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 4 (Delta)1 2     CCT-DELTA2
SRB2 3 5     Cctd2
Stimulator Of TAR RNA-Binding2 3     Chaperonin Containing T-Complex Polypeptide 1, Delta Subunit2
TCP-1-delta2 3     T-Complex Protein 1 Subunit Delta2
CCTD3 5     CCT-delta3

External Ids:    HGNC: 16171   Entrez Gene: 105752   Ensembl: ENSG000001154847   OMIM: 6051425   UniProtKB: P509913   

Export aliases for CCT4 gene to outside databases

Previous GC identifers: GC02M062223 GC02M062281 GC02M062052 GC02M062070 GC02M062069 GC02M062006 GC02M061835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT4 Gene:
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2
back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of
newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially
folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin
(see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 (PubMed 9819444)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for CCT4 Gene:
CCT4 (chaperonin containing TCP1, subunit 4 (delta)) is a protein-coding gene. Diseases associated with CCT4 include sensory peripheral neuropathy, and hereditary sensory neuropathy. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPD_HUMAN, P50991
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT4 gene promoter:
         TBP   C/EBPbeta   PPAR-gamma1   AP-1   TFIID   STAT1beta   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT4 promoter sequence
   Search Chromatin IP Primers for CCT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

CCT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M062095:  view genomic region     (about GC identifiers)

Start:
62,095,224 bp from pter      End:
62,115,939 bp from pter
Size:
20,716 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCPD_HUMAN, P50991 (See protein sequence)
Recommended Name: T-complex protein 1 subunit delta  
Size: 539 amino acids; 57924 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity)
Secondary accessions: B2R6I3 B7Z8B1 F5H5W3 O14870 Q53QP9 Q96C51
Alternative splicing: 2 isoforms:  P50991-1   P50991-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT4: NX_P50991

Explore proteomics data for CCT4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys42, Lys55, Lys65, Lys79, Lys126, Lys139, Lys213, Lys288, Lys319, Lys384,
                                 Lys489, Lys531
  • Modification sites at PhosphoSitePlus

  • See CCT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243650.1  NP_006421.2  

    ENSEMBL proteins: 
     ENSP00000377958   ENSP00000443061   ENSP00000442174   ENSP00000443451  
    Reactome Protein details: P50991

    CCT4 Human Recombinant Protein Products:

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    OriGene MassSpec for CCT4
    OriGene Custom Protein Services for CCT4
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    Novus Biologicals CCT4 Protein
    Novus Biologicals CCT4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT4

    CCT4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CCT4
    OriGene Custom Antibody Services for CCT4
    Novus Biologicals CCT4 Antibodies
    Abcam antibodies for CCT4
    Cloud-Clone Corp. Antibodies for CCT4
    ThermoFisher Antibodies for CCT4
    LSBio Antibodies in human, mouse, rat for CCT4

    CCT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT4
    Cloud-Clone Corp. CLIAs for CCT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR012717 Chap_CCT_delta
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry P50991

    ProtoNet protein and cluster: P50991

    1 Blocks protein domain: IPB002194 Chaperonin TCP-1

    UniProtKB/Swiss-Prot: TCPD_HUMAN, P50991
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPD_HUMAN, P50991
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT4:
    chaperonin containing TCP1 (T complex protein 1) subunit 4 (delta),cytosolic,TF55/TCP-1 family,required for the
    maturation of cyclin E

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    CCT4 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CCT4:
     Cell division defect  Decreased TP53 protein express  Increased G2M DNA content  Increased cell death in breast 
     Increased gamma-H2AX phosphory  Increased number of cells in m  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT4:
    hsa-mir-29a-3p (MIRT049979), hsa-mir-149-5p (MIRT045425), hsa-mir-186-5p (MIRT045238), hsa-mir-1227-3p (MIRT036402), hsa-mir-193b-3p (MIRT041331)

    Block miRNA regulation of human, mouse, rat CCT4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCT4:
    hsa-miR-21* hsa-miR-141* hsa-miR-889 hsa-miR-7 hsa-miR-105 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidCCT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT4
    Predesigned siRNA for gene silencing in human, mouse, rat CCT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT4

    Clone
    Products:
         
    OriGene clones in human, mouse for CCT4 (see all 6)
    OriGene ORF clones in mouse, rat for CCT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT4 (NM_006430)
    Sino Biological Human cDNA Clone for CCT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCT4
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPD_HUMAN, P50991: Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    CCT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT4 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT4
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT4
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC



    CCT4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT4: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT4 (P509912, 3 ENSP000003779584) via UniProtKB, MINT, STRING, and/or I2D (see all 1166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8380842 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000317334
    CCT2P783712, 3, ENSP000002993004MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=5 STRING: ENSP00000299300
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000258091
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT4 (TCPD)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCT4 gene (2 alternative transcripts): 
    NM_001256721.1  NM_006430.3  

    Unigene Cluster for CCT4:

    Chaperonin containing TCP1, subunit 4 (delta)
    Hs.421509  [show with all ESTs]
    Unigene Representative Sequence: NM_006430
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394440(uc002sbo.3 uc010ypq.2 uc010ypr.2 uc010yps.2)
    ENST00000461540 ENST00000461370 ENST00000544079 ENST00000538252 ENST00000544185

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCT4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCT4:
    hsa-miR-21* hsa-miR-141* hsa-miR-889 hsa-miR-7 hsa-miR-105 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidCCT4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCT4
    Predesigned siRNA for gene silencing in human, mouse, rat CCT4
    Clone
    Products:
         
    OriGene clones in human, mouse for CCT4 (see all 6)
    OriGene ORF clones in mouse, rat for CCT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCT4 (NM_006430)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT4
      QuantiTect SYBR Green Assays in human, mouse, rat CCT4
      QuantiFast Probe-based Assays in human, mouse, rat CCT4

    Additional mRNA sequence: 

    AF026291.1 AK129860.1 AK290538.1 AK294665.1 AK295330.1 AK303082.1 AK307856.1 AK308942.1 
    AK312586.1 AK315975.1 BC014676.1 BC106933.1 BC106934.1 U38846.1 

    Selected DOTS entries (see all 37):

    DT.92462628  DT.320494  DT.100045107  DT.99984368  DT.100885641  DT.95275756  DT.100685590  DT.121023241 
    DT.95344643  DT.320495  DT.92462613  DT.100885650  DT.121023341  DT.100885642  DT.100045109  DT.100885651 
    DT.100885643  DT.92462611  DT.92462623  DT.121023343  DT.121282328  DT.40116818  DT.92462635  DT.92462637 

    Selected AceView cDNA sequences (see all 1025):

    BG390694 BG943846 BU859595 AL524202 AL555754 BX359641 AU142378 BU508059 
    AA813917 BU148752 CB139110 AA084152 CK821584 AI081482 BM797962 CR600967 
    BP372908 BQ059820 BF740271 CA420237 BQ216700 BM311612 BM765256 AI337897 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -                                                                                                                           
    SP2:                                                                                            -     -     -                                       
    SP3:                    -                 -     -                                                                                                   
    SP4:                    -                                                                                                                           
    SP5:                    -     -     -           -     -                                                                                             


    ECgene alternative splicing isoforms for CCT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGGGAGA
    CCT4 Expression
    About this image


    CCT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
    CCT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421509
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT4: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT4
    QuantiTect SYBR Green Assays in human, mouse, rat CCT4
    QuantiFast Probe-based Assays in human, mouse, rat CCT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT4 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct41 , 5 chaperonin containing Tcp1, subunit 4 (delta)1, 5 90.72(n)1
    96.66(a)1
      11 (14.25 cM)5
    124641  NM_009837.11  NP_033967.11 
     229905195 
    chicken
    (Gallus gallus)
    Aves CCT41 chaperonin containing TCP1, subunit 4 (delta) 79.54(n)
    91.23(a)
      395414  NM_206878.1  NP_996761.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT46
    chaperonin containing TCP1, subunit 4 (delta)
    90(a)
    1 ↔ 1
    1(121558992-121579144)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3989592 hypothetical protein LOC398959 79.25(n)    BC060448.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc657892 hypothetical protein MGC65789 76.31(n)   393555  BC056719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55251 , 3 chaperonin ATPase3
    CG55251
    70(a)3
    63.75(n)1
    70.43(a)1
      33F33
    346741  NM_135735.21  NP_609579.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-41 , 3 T-complex protein3
    cct-41
    64(a)3
    61.53(n)1
    65.11(a)1
      II(8283591-8285404)3
    1743301  NM_063349.61  NP_495750.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT41 CCT4 60.61(n)
    60.74(a)
      851412   NP_010138.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G181901 AT3G18190 62.65(n)
    66.6(a)
      821346  NM_112702.2  NP_188447.1 
    rice
    (Oryza sativa)
    Liliopsida Os.91142 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.66(n)    AK067672.1 


    ENSEMBL Gene Tree for CCT4 (if available)
    TreeFam Gene Tree for CCT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT4 gene
    8 SIMAP similar genes for CCT4 using alignment to 3 protein entries:     TCPD_HUMAN (see all proteins):
    CCT5    CCT3    CCT2    CCT7    CCT8    TCP1
    CCT6B    CCT6A

    CCT4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCT4
    PGOHUM00000233016 PGOHUM00000260967


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT4 (see all 606)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890353741,2
    --62094778(+) GGCTTC/TAGAAG 2 -- int10--------
    rs350051181,2
    C--62094835(+) CAACAC/TAGTGG 2 -- int10--------
    rs105650691,2
    C--62094854(+) ttctg-/A/AAA 
            
    aaaaa
    4 -- int1 cds10--------
    rs39807251,2
    C,A--62094869(-) TATATA/TTTTTT 2 -- int12Minor allele frequency- T:0.00NA 4
    rs116832361,2
    C,F,H--62094889(+) ATATAC/TACACA 2 -- int13Minor allele frequency- T:0.50NA 6
    rs1381712991,2
    C--62094945(+) ATTCTA/GAAGAA 2 -- int10--------
    rs1852289381,2
    --62095021(+) GCCACC/TGCACT 2 -- int10--------
    rs358407251,2
    C--62095052(+) AAAAA-/ATCACT 2 -- int10--------
    rs1891934211,2
    --62095099(+) ATAGAC/TTGGAA 2 -- int10--------
    rs1816778561,2
    --62095131(+) AGTTAA/CAGATT 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCT4 (62095224 - 62115939 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CCT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657259CNV Deletion23128226
    esv2720131CNV Deletion23290073
    esv34000CNV Loss18971310
    nsv458074CNV Gain19166990
    nsv470467CNV Gain18288195
    nsv874229CNV Gain21882294
    nsv7313OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT4
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605142    OMIM disorders: --

    14 diseases for CCT4:    
    About MalaCards
    sensory peripheral neuropathy    hereditary sensory neuropathy    cerebral cavernous malformations 3    cavernous malformation
    cerebral cavernous malformation    peripheral neuropathy    neuropathy    paraplegia
    cerebritis    spasticity    cystic fibrosis    hepatocellular carcinoma
    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for CCT4:
    Sensory peripheral neuropathy

    CCT4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CCT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sensory neuropathy 70.1 1 16399879 (1)


    Export disorders for CCT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT4 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with CCT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PubMed id 9819444)1, 2, 3 Won K.-A.... Reed S.I. (Mol. Cell. Biol. 1998)
    2. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. (PubMed id 8626763)1, 2, 9 Wu-Baer F.... Gaynor R.B. (J. Biol. Chem. 1996)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11. (PubMed id 8661059)1, 9 Nabetani A....Mukai T. (Genomics 1996)
    9. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10575 HGNC: 1617 AceView: CCT4 Ensembl:ENSG00000115484 euGenes: HUgn10575
    ECgene: CCT4 H-InvDB: CCT4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCT4 gene:
    Search GeneIP for patents involving CCT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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